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Hub Rank	Node	Children	Parents	Degree	Betweenness
#1	ZNF238	180	3	183	402.456
#2	GTF2H2	92	5	97	527.974
#3	ARNTL2	91	7	98	425.467
#4	ETS1	88	4	92	232.116
#5	KLF2	85	7	92	2165.238
#6	BATF	73	4	77	3686.122
#7	NR2F2	72	6	78	8158.991
#8	BTG2	72	4	76	171.156
#9	GATA3	71	6	77	1108.973
#10	HOXB8	60	6	66	1308.779
#11	CDKN2A	60	7	67	961.485
#12	MEF2C	59	8	67	7199.611
#13	HOXB6	57	9	66	916.222
#14	FOXP1	55	3	58	112.605
#15	ELF2	55	6	61	486.735
#16	ZNF140	49	10	59	7041.54
#17	NR3C1	48	10	58	7108.164
#18	IRF6	46	2	48	970.447
#19	CEBPB	45	5	50	2270.294
#20	IRF1	43	6	49	2281.998
#21	ADNP2	39	6	45	883.741
#22	STAT5B	38	4	42	121.443
#23	E2F1	38	9	47	5755.961
#24	TSC22D3	36	10	46	1576.402
#25	STAT6	36	14	50	9087.553
#26	NFE2	36	11	47	11909.211
#27	PRDM2	35	7	42	4258.82
#28	ETV6	35	6	41	2332.811
#29	STAT4	33	9	42	3669.078
#30	HOXC10	33	7	40	1104.63
#31	KLF3	33	16	49	8397.143
#32	REL	31	4	35	2982.919
#33	TFAP2A	30	6	36	2648.683
#34	NR2F1	30	6	36	2298.683
#35	HMGA2	29	7	36	5013.831
#36	FOXD1	29	6	35	438.578
#37	IRF8	28	8	36	23615.285
#38	KLF12	28	9	37	5780.455
#39	ZNF148	28	12	40	933.559
#40	NOTCH1	27	12	39	2881.293
#41	SIM2	27	7	34	1544.915
#42	SCAND1	26	10	36	4584.296
#43	HOPX	26	10	36	25036.409
#44	CREBBP	26	5	31	600.404
#45	TCF19	26	8	34	911.199
#46	BCL6	25	7	32	1511.253
#47	SOX9	25	11	36	16073.118
#48	NR2F6	25	10	35	1317.969
#49	TSC22D1	25	7	32	987.034
#50	HDAC2	25	9	34	2362.734
#51	HOXA9	24	6	30	939.956
#52	ZFHX4	24	6	30	758.791
#53	IRF5	24	6	30	466.415
#54	IRF2	23	10	33	4543.549
#55	ZNF394	23	11	34	1158.232
#56	HCLS1	23	4	27	2527.992
#57	C1orf85	23	10	33	1089.56
#58	RUNX3	23	9	32	1631.434
#59	ATF6	22	9	31	1141.34
#60	HOXA7	22	5	27	198.529
#61	MAX	22	5	27	1898.276
#62	RORA	22	6	28	506.254
#63	ALX1	21	9	30	3143.442
#64	MSX1	21	4	25	310.744
#65	ZHX2	21	10	31	1930.593
#66	NPAT	21	8	29	1858.278
#67	TEAD1	21	11	32	1764.01
#68	HOXB7	21	8	29	433.701
#69	BACH1	21	8	29	1261.379
#70	NCOR1	21	10	31	2140.632
#71	IRF7	20	13	33	2208.675
#72	PURA	20	11	31	1542.957
#73	TCF7	20	8	28	306.215
#74	RBPJ	20	7	27	1007.169
#75	SIX4	19	5	24	875.697
#76	PHF1	19	4	23	1356.494
#77	GLIS2	19	10	29	2116.172
#78	CEBPA	19	9	28	2197.329
#79	SREBF1	19	9	28	585.267
#80	TBX21	19	9	28	3852.767
#81	NR1H2	19	9	28	286.191
#82	SNAPC5	18	12	30	4831.598
#83	SOX6	18	10	28	1065.046
#84	E2F7	18	8	26	8777.954
#85	MYBL2	18	7	25	330.62
#86	TFE3	18	7	25	293.368
#87	SATB1	18	7	25	394.384
#88	C5orf41	17	8	25	549.792
#89	NFIB	17	8	25	185.371
#90	TFEC	17	4	21	9717.044
#91	NOLC1	16	10	26	2283.103
#92	PRDM1	16	12	28	8843.052
#93	KDM5A	16	11	27	1408.608
#94	CREBL2	16	13	29	4926.627
#95	FOXM1	16	7	23	356.042
#96	TRIM25	16	8	24	237.97
#97	SMAD1	16	10	26	2389.155
#98	PCGF2	15	11	26	1555.617
#99	SP3	15	9	24	1429.586
#100	HOXA5	15	8	23	3800.277
#101	GTF2I	15	2	17	39.677
#102	MSX2	15	6	21	167.673
#103	ELF1	15	9	24	3505.87
#104	BLZF1	15	16	31	10752.458
#105	SATB2	15	10	25	7136.731
#106	CTNNB1	15	8	23	1428.499
#107	XBP1	14	7	21	786.118
#108	MXD1	14	10	24	8756.498
#109	NKX2-1	13	5	18	2154.178
#110	ZIC1	13	5	18	297.574
#111	CNOT8	13	8	21	782.507
#112	UHRF1	13	10	23	1537.203
#113	MTA3	13	10	23	373.011
#114	SIX1	13	11	24	4685.894
#115	CREB1	13	8	21	10493.153
#116	TSHZ2	13	11	24	4574.157
#117	MAFG	13	14	27	3748.715
#118	FOXP2	13	6	19	2338.812
#119	RELB	13	7	20	138.784
#120	ELF4	13	12	25	1375.25
#121	RARA	12	9	21	9620.598
#122	ZNF85	12	11	23	1135.036
#123	BRD8	12	10	22	1087.747
#124	HOXB4	12	11	23	2566.308
#125	RUNX1T1	12	11	23	293.759
#126	TCF7L2	12	10	22	1343.345
#127	PPARD	12	9	21	905.648
#128	ZIC2	12	8	20	338.648
#129	ZFP36L2	12	10	22	4152.274
#130	CREBZF	12	9	21	992.149
#131	CREM	12	11	23	25832
#132	FOXK1	12	6	18	43.539
#133	ZNF219	11	8	19	237.793
#134	PCGF6	11	10	21	1078.15
#135	ZNF217	11	12	23	11902.484
#136	PBX3	11	10	21	816.1
#137	TCEAL1	11	11	22	545.394
#138	SP1	11	17	28	4145.163
#139	NFE2L2	11	18	29	6191.394
#140	CBFA2T2	11	12	23	16582.33
#141	TAF7	11	12	23	2376.535
#142	EOMES	11	10	21	5338.054
#143	TEAD3	11	7	18	164.917
#144	ZFP36L1	11	11	22	656.812
#145	GATAD2B	11	12	23	1363.393
#146	HMGB2	11	16	27	718.692
#147	ZEB2	10	8	18	5145.196
#148	TEAD4	10	11	21	2244.506
#149	PAX6	10	7	17	99.869
#150	TEAD2	10	12	22	1222.762
#151	PHF5A	10	8	18	6568
#152	TBX5	10	7	17	881.877
#153	FOXA1	10	10	20	10866.542
#154	FOXN2	10	14	24	394.234
#155	FOXO3	10	10	20	8130.622
#156	TAF1B	10	11	21	2256.22
#157	BNC1	10	11	21	3966.643
#158	E2F8	10	11	21	2226.605
#159	PTTG1	10	8	18	517.696
#160	EPAS1	9	8	17	590.062
#161	HR	9	12	21	1758.648
#162	ATF7	9	13	22	9142.671
#163	HOXA10	9	9	18	1022.703
#164	MEIS3P1	9	8	17	450.008
#165	GATA6	9	10	19	10811.72
#166	E2F6	9	10	19	5392.9
#167	TAL1	9	9	18	391.674
#168	EGR3	9	14	23	2198.649
#169	SCML1	9	13	22	1552.323
#170	JUNB	9	13	22	9347.494
#171	HDAC1	9	12	21	340.798
#172	ZNF117	9	13	22	3615.179
#173	TFAP2C	9	10	19	479.946
#174	GTF2IRD1	9	14	23	1550.666
#175	ZHX1	9	14	23	553.15
#176	MNX1	8	7	15	60.03
#177	ZNF274	8	9	17	1146.963
#178	WNT5A	8	14	22	1595.139
#179	ETV4	8	13	21	5049.878
#180	MLX	8	7	15	4107.409
#181	TFDP1	8	15	23	741.338
#182	C2orf3	8	11	19	342.782
#183	HOXA11	8	5	13	23.28
#184	GLI2	8	8	16	417.456
#185	ZNF207	8	11	19	429.723
#186	NKX6-1	8	6	14	2413.707
#187	FOSL2	8	6	14	196.554
#188	L3MBTL4	8	10	18	361.844
#189	CREB3	8	9	17	72.609
#190	CIR1	8	9	17	11707.122
#191	NR6A1	8	4	12	845.02
#192	ENO1	8	14	22	5501.77
#193	FBXW7	8	10	18	514.066
#194	HOXA3	7	11	18	134.472
#195	EHF	7	7	14	3673.554
#196	BACH2	7	8	15	3139.744
#197	ZNF91	7	14	21	810.592
#198	FOXN3	7	17	24	488.27
#199	ZNF92	7	6	13	286.693
#200	ADNP	7	9	16	86.588
#201	ZNF138	7	9	16	1574.374
#202	ZNF33B	7	7	14	637.877
#203	ZFP42	7	6	13	802.439
#204	AHR	7	12	19	1088.322
#205	ZBTB17	7	8	15	443.669
#206	ONECUT2	7	13	20	424.609
#207	RELA	7	10	17	2021.65
#208	SOX10	7	7	14	1178.251
#209	CTBP1	6	14	20	10729.192
#210	ARID4A	6	8	14	1794.268
#211	TGIF1	6	14	20	8746.407
#212	CREB5	6	11	17	3602.689
#213	THRB	6	4	10	17.453
#214	KLF4	6	10	16	212.423
#215	ZNF131	6	6	12	305.463
#216	LEF1	6	10	16	1179.092
#217	TRIM29	6	5	11	195.838
#218	FOXO6	6	12	18	1271.883
#219	GAS7	6	12	18	3101.88
#220	STAT5A	6	7	13	234.154
#221	MEF2A	6	8	14	873.19
#222	TSC22D4	6	12	18	263.363
#223	SMAD9	6	13	19	152.274
#224	STAT3	6	13	19	2486.707
#225	IKZF1	6	6	12	30.395
#226	FOXO1	6	13	19	241.501
#227	TWIST2	6	8	14	707.501
#228	PURB	6	19	25	735.551
#229	CEBPD	6	7	13	1388.966
#230	ZNF215	6	10	16	445.386
#231	ZBTB48	6	11	17	3436.258
#232	TSHZ1	6	9	15	1251.134
#233	STAT2	6	10	16	5544.18
#234	RUNX1	5	8	13	207.463
#235	IRX4	5	9	14	321.704
#236	MEIS2	5	12	17	289.411
#237	NFIA	5	13	18	346.529
#238	MKX	5	10	15	721.028
#239	HES6	5	12	17	2842.641
#240	SMAD5	5	14	19	8594.622
#241	NFATC2	5	9	14	731.86
#242	ZBTB38	5	11	16	532.636
#243	SMAD4	5	14	19	4432.216
#244	KLF9	5	9	14	738.614
#245	ZFP90	5	9	14	1232.328
#246	TBX10	5	9	14	723.803
#247	ASCL2	5	7	12	1223.081
#248	HNF4G	5	7	12	51.399
#249	ETV1	5	5	10	587.655
#250	MTF1	5	9	14	248.806
#251	ZEB1	5	7	12	59.853
#252	RUNX2	5	10	15	116.02
#253	SOX4	5	13	18	776.184
#254	MLL	5	7	12	1313.172
#255	SLC30A9	5	11	16	194.177
#256	MAFB	5	11	16	209.066
#257	HMG20B	5	9	14	310.631
#258	KLF5	5	9	14	5467.831
#259	LHX2	5	9	14	194.638
#260	HSF2	5	9	14	1466.13
#261	ZNF33A	5	13	18	249.095
#262	PLAGL2	5	9	14	2250.597
#263	TFEB	5	11	16	897.941
#264	TSC22D2	4	12	16	81.016
#265	YBX1	4	14	18	14518.375
#266	RAX	4	12	16	418.397
#267	ELK1	4	6	10	126.541
#268	VDR	4	11	15	1662.769
#269	TCF4	4	12	16	2974.851
#270	EBF1	4	10	14	4926.028
#271	MTA1	4	10	14	2120.924
#272	FOSB	4	13	17	603.13
#273	KDM5B	4	13	17	4365.194
#274	PITX1	4	9	13	2040.702
#275	TLX3	4	9	13	194.263
#276	NFATC3	4	11	15	674.179
#277	JUN	4	15	19	110.953
#278	KLF7	4	12	16	519.263
#279	ZNF197	4	7	11	171.73
#280	SPIB	4	9	13	986.027
#281	ZNF367	4	11	15	625.873
#282	HNRNPAB	4	8	12	38.581
#283	TAF4	4	12	16	182.321
#284	ZNF639	4	14	18	160.419
#285	TBX3	4	12	16	4342.694
#286	ZNF3	4	10	14	211.876
#287	ZKSCAN1	4	13	17	1469.051
#288	HMG20A	4	12	16	3354.21
#289	AFF4	4	10	14	322.865
#290	SP4	4	11	15	12735.476
#291	EGR2	4	10	14	764.691
#292	ZNF37A	4	12	16	6710.927
#293	FOS	4	13	17	489.547
#294	ZFPM1	4	10	14	701.96
#295	PGBD1	4	9	13	2295.198
#296	SCML2	4	7	11	232.298
#297	TAF5	4	13	17	336.156
#298	NFE2L3	3	10	13	675.686
#299	CUX1	3	10	13	139.426
#300	ZNF281	3	13	16	7194.283
#301	ZNF397	3	13	16	4057.594
#302	KLF10	3	14	17	203.189
#303	FOXE1	3	9	12	12450.578
#304	TFAM	3	6	9	91.512
#305	BCL3	3	11	14	704.437
#306	FOXC1	3	7	10	98.554
#307	KLF6	3	15	18	5654.431
#308	PAX7	3	8	11	390.939
#309	NR3C2	3	9	12	471.5
#310	CBFB	3	9	12	144.94
#311	NANOGNB	3	12	15	211.044
#312	NFIL3	3	10	13	277.023
#313	RCAN1	3	10	13	1991.005
#314	VENTX	3	10	13	2849.26
#315	FOXK2	3	8	11	63.526
#316	SIX5	3	8	11	1065.966
#317	TFCP2	3	7	10	624.681
#318	NR0B1	3	8	11	147.285
#319	TCF3	3	12	15	558.691
#320	ZSCAN16	3	10	13	297.095
#321	FLI1	3	6	9	111.281
#322	ZNF628	3	8	11	307.876
#323	AFF1	3	14	17	397.621
#324	TAF12	3	8	11	3866.186
#325	SLC2A4RG	3	13	16	148.792
#326	TADA2A	3	8	11	171.82
#327	ZNF133	3	11	14	12237.369
#328	HMGA1	3	9	12	11724.937
#329	IRF4	2	8	10	22.531
#330	MLLT10	2	9	11	6392.738
#331	STRN3	2	10	12	23.439
#332	FUBP1	2	20	22	18020.599
#333	MMP14	2	7	9	1322.636
#334	DBP	2	8	10	12.219
#335	RFX5	2	13	15	62.286
#336	BHLHE41	2	13	15	208.94
#337	ZNF45	2	17	19	75.371
#338	HOXC9	2	8	10	37.958
#339	MYT1	2	6	8	18.777
#340	ZNF24	2	13	15	753.661
#341	ARID3A	2	8	10	194.441
#342	OVOL1	2	14	16	35.751
#343	NFIX	2	9	11	43.57
#344	NFYA	2	13	15	599.22
#345	LMO4	2	11	13	85.407
#346	BHLHE40	2	12	14	294.639
#347	GRHL2	2	7	9	50.555
#348	GABPB1	2	12	14	98.516
#349	ISL2	2	10	12	156.064
#350	E2F3	2	13	15	89.186
#351	HSF1	2	9	11	520.961
#352	NR4A3	2	11	13	2273.122
#353	MSC	2	10	12	223.516
#354	ZXDA	2	15	17	978.917
#355	ZNF434	2	10	12	2454.744
#356	HOXB5	2	7	9	63.427
#357	CCRN4L	2	13	15	132.568
#358	MYNN	2	14	16	144.807
#359	MNT	2	12	14	10760.741
#360	NFKB1	2	12	14	541.237
#361	ZNF19	2	14	16	536.494
#362	NKX3-1	2	8	10	702.187
#363	HOXA2	2	9	11	122.727
#364	NFATC1	2	9	11	58.611
#365	DLX1	2	9	11	180.32
#366	CREB3L4	2	10	12	25.922
#367	NR2C2	2	13	15	639.438
#368	HOXB9	2	10	12	99.767
#369	TARDBP	2	15	17	146.789
#370	HIC1	2	13	15	68.861
#371	HOXC8	2	11	13	37.036
#372	DRAP1	2	12	14	1029.874
#373	HIF3A	2	9	11	72.536
#374	ZSCAN18	2	9	11	174.073
#375	ATF5	2	14	16	946.087
#376	ZNF268	2	11	13	3503.269
#377	POU6F1	2	8	10	163.052
#378	RXRA	2	12	14	200.41
#379	LHX6	2	7	9	121.159
#380	ARNT	1	13	14	166.105
#381	NFX1	1	13	14	177.284
#382	ZNF256	1	8	9	794.788
#383	ZNF232	1	11	12	15.199
#384	TSHZ3	1	10	11	302.081
#385	MAFK	1	18	19	53.769
#386	ESR1	1	11	12	155.367
#387	YY1	1	18	19	3297.438
#388	HNF1B	1	16	17	145.394
#389	CBFA2T3	1	9	10	7.947
#390	MITF	1	8	9	30.534
#391	NR2C1	1	16	17	188.612
#392	NR4A2	1	16	17	4778.804
#393	TCF12	1	10	11	24.377
#394	HEYL	1	9	10	20.337
#395	CNOT7	1	16	17	1607.2
#396	NFYB	1	13	14	57.65
#397	BCL11B	1	11	12	817.171
#398	MGA	1	12	13	130.335
#399	SNAI3	1	12	13	907.224
#400	ZNF83	1	13	14	32.297
#401	HAND1	1	9	10	666.359
#402	ZIC3	1	4	5	23.139
#403	PITX2	1	9	10	57.222
#404	SIN3A	1	11	12	12381
#405	TULP4	1	12	13	45.232
#406	POU2F2	1	10	11	66.342
#407	ZXDC	1	7	8	77.773
#408	ZGPAT	1	6	7	355.827
#409	ZNF500	1	13	14	96.373
#410	PLAG1	1	7	8	6.65
#411	ATF2	1	15	16	51.853
#412	STAT1	1	14	15	187.743
#413	HMGB1	1	14	15	56.948
#414	RFXAP	1	13	14	77.059
#415	C11orf9	1	13	14	24.434
#416	PA2G4	1	12	13	40.557
#417	CSDA	1	10	11	163.636
#418	JUND	1	10	11	624.001
#419	ZNF135	1	10	11	1527.898
#420	MAF	1	13	14	572.738
#421	TP63	1	6	7	343.814
#422	ZNF75D	1	12	13	46.019
#423	AHCTF1	1	16	17	56.33
#424	ZKSCAN5	1	9	10	1079.913
#425	KLF11	1	12	13	24.646
#426	NFKB2	1	7	8	196.027
#427	PPARA	1	14	15	91.368
#428	CBL	1	12	13	2690.104
#429	SP140	1	5	6	469.745
#430	ZNF277	1	13	14	10.734
#431	ZSCAN5A	1	12	13	164.142
#432	ELK3	1	10	11	15.156
#433	SOX8	1	9	10	9.661
#434	NFIC	1	14	15	1112.988
#435	MECOM	1	6	7	177.351
#436	NR1D2	1	11	12	104.218
#437	ELF3	1	12	13	90.136
#438	GABPA	1	14	15	1847.305
#439	MSRB2	0	13	13	0
#440	HOXB2	0	14	14	0
#441	HES1	0	11	11	0
#442	CSRNP1	0	16	16	0
#443	TAF5L	0	10	10	0
#444	DLX4	0	12	12	0
#445	YEATS4	0	15	15	0
#446	HOXB3	0	9	9	0
#447	ZNF189	0	12	12	0
#448	TRIM22	0	11	11	0
#449	ETV5	0	12	12	0
#450	TRERF1	0	14	14	0
#451	CTCF	0	11	11	0
#452	MAFF	0	18	18	0
#453	SMAD3	0	10	10	0
#454	MEF2D	0	10	10	0
#455	POU2F1	0	9	9	0
#456	SMAD6	0	8	8	0
#457	ZNF167	0	15	15	0
#458	IRF9	0	15	15	0
#459	CSRNP2	0	10	10	0
#460	TCF7L1	0	10	10	0
#461	ARNTL	0	15	15	0
#462	SCAND2	0	7	7	0
#463	PHTF1	0	11	11	0
#464	CNBP	0	14	14	0
#465	FOSL1	0	14	14	0
#466	RB1	0	7	7	0
#467	MBD1	0	8	8	0
#468	PLSCR1	0	16	16	0
#469	SOLH	0	13	13	0
#470	CITED2	0	15	15	0
#471	ARNT2	0	7	7	0
#472	MSL3	0	13	13	0
#473	ETS2	0	14	14	0
#474	NFYC	0	18	18	0
#475	E2F2	0	11	11	0
#476	NFAT5	0	11	11	0
#477	NFXL1	0	11	11	0
#478	EGR1	0	15	15	0
#479	DLX2	0	12	12	0
#480	FOXF1	0	11	11	0
#481	VAV1	0	9	9	0
#482	NR4A1	0	10	10	0
#483	TRPS1	0	7	7	0
#484	LASS6	0	14	14	0
#485	ZNF165	0	14	14	0
#486	FOXQ1	0	7	7	0
#487	MYC	0	15	15	0
#488	ZFHX3	0	12	12	0
#489	CREB3L2	0	12	12	0
#490	SPI1	0	14	14	0
#491	E2F5	0	17	17	0
#492	TGIF2	0	7	7	0
#493	GATA2	0	14	14	0
#494	HHEX	0	18	18	0
#495	SPEN	0	12	12	0
#496	GATAD1	0	12	12	0
#497	ATF1	0	10	10	0
#498	HOXA1	0	12	12	0
#499	TP53	0	11	11	0
#500	SCAND3	0	12	12	0