Hub Rank	Node	Children	Parents	Degree	Betweenness
#1	ZNF215	38	3	41	1369
#2	BATF3	31	2	33	273.642
#3	CEBPB	29	1	30	559.003
#4	SOX4	27	6	33	1349.772
#5	RERE	26	10	36	6081.555
#6	NR3C1	26	7	33	3382.57
#7	GABPB1	26	6	32	1844.117
#8	E2F6	25	11	36	7143.112
#9	E2F8	23	8	31	1549.73
#10	FOXJ3	23	7	30	2610.569
#11	LHX2	23	6	29	2871.53
#12	NFATC2	22	3	25	280.036
#13	HES5	22	7	29	1190.458
#14	SMAD3	22	7	29	3237.127
#15	ELF4	22	3	25	943.307
#16	LHX6	21	10	31	2457.543
#17	MAFG	21	3	24	682.949
#18	ZNF131	21	5	26	1119.158
#19	STAT5B	21	1	22	406.138
#20	FOXL1	21	5	26	2090.114
#21	ESRRG	21	8	29	1300.364
#22	FOXA2	21	6	27	1936.23
#23	MESP1	21	5	26	1791.275
#24	DDIT3	21	2	23	101.769
#25	FOSL1	20	3	23	796.189
#26	NR1D1	20	3	23	114.987
#27	SALL2	20	6	26	2301.017
#28	ZFP90	20	11	31	3372.15
#29	FOSB	20	7	27	3730.733
#30	HEYL	20	9	29	4157.755
#31	ZNF189	20	6	26	7529.061
#32	HMGA1	20	9	29	6227.421
#33	ZFP36L1	19	6	25	2372.144
#34	PBX1	19	6	25	424.854
#35	IRF7	19	10	29	4673.661
#36	BCL3	19	6	25	422.679
#37	AFF4	19	5	24	975.992
#38	HOXA10	18	6	24	1410.463
#39	ZNF93	18	8	26	2500.02
#40	ASCL2	18	7	25	958.082
#41	CEBPE	18	5	23	1623.827
#42	PLSCR1	18	7	25	1229.915
#43	NKX1-2	18	2	20	63.963
#44	EVX1	18	3	21	141.14
#45	KLF2	18	10	28	549.505
#46	CSRNP1	18	8	26	517.453
#47	SIX4	18	9	27	5468.79
#48	HES1	18	14	32	4995.635
#49	STAT6	18	7	25	2864.216
#50	HOXB5	17	7	24	2924.065
#51	TFCP2L1	17	12	29	1880.08
#52	PKNOX1	17	10	27	1917.492
#53	GSC	17	11	28	1369.411
#54	SIX3	17	9	26	8188.734
#55	IRF1	17	3	20	127.871
#56	ELK3	16	5	21	270.309
#57	RUNX3	16	8	24	1368.299
#58	EGR4	16	6	22	2083.988
#59	HOXC10	16	4	20	478.815
#60	ZBTB38	16	5	21	694.44
#61	KLF4	16	6	22	668.734
#62	BACH1	16	9	25	1258.89
#63	HMG20A	16	6	22	1180.567
#64	ZNF165	16	6	22	416.897
#65	ETS1	16	8	24	1374.305
#66	NFE2L1	16	13	29	4280.309
#67	FOXE1	16	4	20	403.541
#68	KLF3	16	13	29	2122.021
#69	TADA3	16	10	26	1657.136
#70	RB1	16	8	24	4811.432
#71	RELB	16	3	19	1257.093
#72	LEF1	16	9	25	3519.591
#73	TSC22D2	16	5	21	696.562
#74	CITED1	15	12	27	1209.881
#75	TBX3	15	7	22	427.963
#76	SREBF2	15	10	25	1342.351
#77	NR4A1	15	9	24	2649.421
#78	NR2F1	15	12	27	3592.998
#79	MAFK	15	8	23	1024.497
#80	HNF1A	15	10	25	3356.644
#81	ZC3H8	15	8	23	2580.185
#82	C5orf41	15	12	27	930.886
#83	PRDM1	15	7	22	781.879
#84	MTF1	15	8	23	1454.069
#85	SOX17	15	1	16	92.813
#86	ZHX1	15	13	28	2852.478
#87	ZNF643	15	15	30	5025.926
#88	ETV3	15	7	22	2290.85
#89	FOXD3	15	9	24	4851.134
#90	ARNT2	15	5	20	759.044
#91	HOXA4	15	2	17	488.115
#92	FOXA1	15	7	22	4784.03
#93	TCF3	14	14	28	2749.438
#94	FBXW7	14	9	23	7440.056
#95	ZSCAN1	14	7	21	3289.257
#96	ZNF217	14	3	17	141.302
#97	SOX9	14	5	19	1062.293
#98	DLX4	14	11	25	3293.575
#99	MAF	14	5	19	729.431
#100	NFE2	14	11	25	2614.686
#101	SUPT4H1	14	6	20	2005.464
#102	TFDP2	14	16	30	1675.326
#103	JUN	14	12	26	664.961
#104	ZNF434	14	13	27	3991.81
#105	SOX1	14	5	19	2428.2
#106	ZKSCAN4	14	3	17	2055.605
#107	SNAPC5	14	8	22	2081.709
#108	PRRX2	14	9	23	973.671
#109	PITX2	14	9	23	901.277
#110	MAFA	14	4	18	690.193
#111	ZNF117	14	3	17	1313.105
#112	MAX	14	9	23	899.083
#113	HOXC9	14	7	21	943.297
#114	TGIF1	14	9	23	3032.152
#115	RFX5	14	6	20	1121.9
#116	TEF	13	8	21	738.058
#117	MYPOP	13	4	17	165.34
#118	HOXA3	13	13	26	4328.214
#119	FOXQ1	13	1	14	105.347
#120	RXRA	13	4	17	306.752
#121	EMX1	13	9	22	835.418
#122	CSDA	13	7	20	883.034
#123	FOSL2	13	11	24	770.64
#124	PURB	13	8	21	1428.65
#125	MYBL2	13	7	20	2525.68
#126	ADNP	13	9	22	2922.348
#127	MAFF	13	4	17	93.722
#128	MBD1	13	11	24	2316.205
#129	TBX2	13	13	26	3522.359
#130	SREBF1	13	11	24	1810.617
#131	ATF6B	13	9	22	1352.882
#132	DMRT2	12	7	19	1183.757
#133	NFIX	12	11	23	2332.429
#134	POU3F2	12	6	18	248.701
#135	HCFC1	12	5	17	807.141
#136	EN2	12	8	20	417.002
#137	TFE3	12	4	16	340.406
#138	HINFP	12	8	20	1072.768
#139	GLI3	12	7	19	584.722
#140	ZNF438	12	10	22	1139.439
#141	GTF2I	12	9	21	546.015
#142	IRF5	12	11	23	2807.115
#143	SOX8	12	2	14	14.103
#144	ATF5	12	8	20	1313.859
#145	ETV4	12	10	22	1029.059
#146	POU5F2	12	6	18	2384.268
#147	NEUROG1	12	2	14	172.133
#148	TSC22D1	12	18	30	3125.471
#149	ZNF138	12	9	21	1654.927
#150	PPARD	12	10	22	4343.162
#151	TAF10	12	9	21	1807.236
#152	EGR3	12	10	22	2404.631
#153	MXD1	12	7	19	661.393
#154	ZNF639	12	13	25	2698.708
#155	E2F2	12	15	27	4193.548
#156	TRIM28	11	10	21	950.112
#157	CNBP	11	9	20	1788.608
#158	RUNX2	11	13	24	3564.787
#159	PHOX2A	11	3	14	101.088
#160	CUX1	11	6	17	1543.512
#161	HOXA13	11	5	16	410.727
#162	MSL3	11	11	22	5449.061
#163	PITX3	11	3	14	291.294
#164	DBP	11	9	20	1194.943
#165	NFXL1	11	6	17	2847.76
#166	RBCK1	11	11	22	1013.132
#167	ZHX3	11	9	20	2401.317
#168	DLX2	11	8	19	2783.826
#169	GLI2	11	11	22	3700.44
#170	MLL	11	10	21	2380.72
#171	NFKB2	11	9	20	2384.627
#172	FOXL2	11	9	20	760.705
#173	FOXJ2	11	10	21	2114.299
#174	ARID4A	11	9	20	936.509
#175	ZNF33A	11	12	23	815.107
#176	ZIC5	11	9	20	3424.39
#177	THRA	10	9	19	486.979
#178	MSX2	10	8	18	864.559
#179	ELK1	10	10	20	2017.785
#180	IRX2	10	9	19	2255.77
#181	TCF7	10	9	19	1808.911
#182	MGA	10	9	19	1235.436
#183	PROX1	10	8	18	474.525
#184	SCML1	10	14	24	2095.577
#185	CREB1	10	10	20	1377.808
#186	NCOR1	10	10	20	2674.944
#187	PBX3	10	12	22	4012.616
#188	ELF5	10	7	17	929.738
#189	MYCN	10	4	14	84.661
#190	NOTCH1	10	15	25	1312.512
#191	NFATC3	10	13	23	3146.131
#192	SP3	10	7	17	4471.76
#193	USF2	10	7	17	631.894
#194	GBX2	10	9	19	1262.874
#195	GTF2IRD1	10	4	14	617.976
#196	TLX2	10	6	16	320.292
#197	SOX2	10	14	24	5411.031
#198	SCAND3	10	11	21	2778.167
#199	ZNF277	10	10	20	2451.125
#200	CTBP1	10	7	17	527.597
#201	SIX1	10	8	18	3538.281
#202	STRN3	10	6	16	1224.592
#203	ZSCAN22	10	6	16	440.833
#204	CREB3L2	10	11	21	564.353
#205	RUNX1	10	4	14	254.878
#206	ZNF367	9	11	20	1063.013
#207	FOXC2	9	6	15	317.292
#208	RARA	9	3	12	192.839
#209	SCRT2	9	7	16	510.774
#210	NFIL3	9	4	13	536.427
#211	FOXO3	9	9	18	1404.354
#212	POU4F2	9	4	13	1678.909
#213	BLZF1	9	7	16	1022.648
#214	HCLS1	9	9	18	1556.099
#215	PAX6	9	10	19	856.539
#216	HOXB6	9	9	18	1454.871
#217	STAT2	9	10	19	1100.016
#218	NKX2-3	9	7	16	1781.824
#219	NR1H2	9	7	16	1057.578
#220	KLF12	9	9	18	2104.111
#221	HOXC8	9	4	13	408.835
#222	ATF3	9	10	19	2165.245
#223	EDF1	9	11	20	1888.861
#224	MTA3	9	9	18	1916.163
#225	ZNF219	9	11	20	558.903
#226	SP140	8	10	18	797.107
#227	KLF11	8	7	15	88.906
#228	TCF15	8	8	16	1070.015
#229	FOXC1	8	7	15	710.459
#230	TAF1B	8	6	14	1090.029
#231	SNAI2	8	14	22	1124.271
#232	HOXC13	8	12	20	1604.12
#233	PAX4	8	9	17	5387.762
#234	CLOCK	8	17	25	1678.114
#235	CCRN4L	8	9	17	588.112
#236	TFAM	8	11	19	684.478
#237	ZNF24	8	12	20	4320.136
#238	ZSCAN10	8	6	14	162.134
#239	FOS	8	15	23	1663.885
#240	FOXS1	8	12	20	991.34
#241	ZIM2	8	7	15	1018.957
#242	TULP4	8	13	21	971.788
#243	TAF4	8	11	19	1176.739
#244	TRIM29	8	9	17	1647.435
#245	WNT5A	8	17	25	2269.439
#246	PHF1	8	8	16	947.743
#247	FOXN2	8	7	15	307.727
#248	HOXB3	8	11	19	2190.086
#249	PPARG	8	14	22	591.744
#250	SIX5	8	11	19	2056.555
#251	ZXDC	8	7	15	1298.279
#252	ZNF91	8	7	15	1299.422
#253	MMP14	8	8	16	888.508
#254	HLF	8	10	18	1344.061
#255	SOX21	8	7	15	299.814
#256	MEF2D	8	9	17	3814.16
#257	CDX2	8	8	16	962.416
#258	HIRA	8	8	16	502.895
#259	HOXB4	8	7	15	1538.951
#260	LZTS1	8	15	23	2529.34
#261	ZNF148	8	10	18	1858.559
#262	BHLHE41	8	9	17	1024.633
#263	ZFPM1	8	6	14	319.629
#264	TADA2A	7	15	22	2884.007
#265	TCF4	7	8	15	245.908
#266	DLX3	7	7	14	463.634
#267	FOXD1	7	10	17	2151.969
#268	JUNB	7	9	16	1293.183
#269	CTNNB1	7	9	16	1449.52
#270	ONECUT2	7	15	22	1030.087
#271	KLF10	7	13	20	733.607
#272	KLF5	7	8	15	519.57
#273	TWIST2	7	10	17	1414.594
#274	TRERF1	7	17	24	4718.76
#275	FOXI3	7	6	13	390.655
#276	HHEX	7	9	16	907.937
#277	HAND1	7	7	14	568.552
#278	RFXAP	7	15	22	2260.883
#279	NEUROD2	7	11	18	2052.241
#280	EHF	7	11	18	755.042
#281	FOXF1	7	11	18	251.816
#282	SNAPC4	7	13	20	2085.963
#283	IKZF4	7	12	19	1517.148
#284	MNT	7	8	15	495.107
#285	ESRRB	7	11	18	1311.613
#286	ZNF140	7	14	21	1819.881
#287	TRIM25	7	13	20	1442.333
#288	ERG	7	8	15	2417.371
#289	ARNTL	7	10	17	990.837
#290	HIF1A	7	9	16	1106.688
#291	ZNF92	7	1	8	10.928
#292	E2F3	7	13	20	1635.747
#293	NEUROD1	7	10	17	2726.842
#294	MEIS3P1	7	12	19	699.778
#295	PAX7	7	5	12	363.132
#296	ZNF37A	6	12	18	1823.893
#297	ZSCAN20	6	11	17	2960.65
#298	ATF4	6	12	18	1354.184
#299	NFAT5	6	11	17	241.354
#300	HOXB2	6	8	14	964.366
#301	TCF25	6	8	14	867.384
#302	MTA1	6	4	10	223.783
#303	CREB3L1	6	7	13	356.746
#304	NR1D2	6	9	15	311.574
#305	NKX3-2	6	7	13	914.318
#306	SMAD2	6	8	14	523.823
#307	PFDN1	6	8	14	1337.177
#308	AHCTF1	6	6	12	747.044
#309	ATF7	6	11	17	2683.936
#310	NFATC1	6	8	14	413.587
#311	ISL2	6	15	21	1351.606
#312	ZFP36L2	6	11	17	518.11
#313	FOXB1	6	3	9	9.962
#314	ELF1	6	6	12	647.994
#315	FOXM1	6	14	20	1170.753
#316	HOXC5	6	10	16	259.92
#317	SCMH1	6	10	16	2120.424
#318	HES6	6	13	19	1098.95
#319	MYC	6	13	19	558.558
#320	ZNF197	6	8	14	2704.745
#321	FOXP2	6	6	12	1829.951
#322	ZNF85	6	8	14	483.058
#323	TFDP3	6	9	15	1320.346
#324	LASS6	6	11	17	1418.476
#325	BATF	6	9	15	673.552
#326	IRX4	6	3	9	16.101
#327	OVOL1	6	10	16	874.176
#328	ZNF169	6	7	13	722.087
#329	PRDM2	6	9	15	673.331
#330	ZNF397	5	9	14	622.448
#331	SLC26A3	5	7	12	4358.421
#332	BATF2	5	10	15	325.585
#333	ZNF446	5	10	15	1734.751
#334	ZNF155	5	12	17	1018.049
#335	GLIS3	5	13	18	730.689
#336	CSRNP3	5	9	14	690.676
#337	ZNF449	5	11	16	715.647
#338	ESR1	5	5	10	530.326
#339	PURA	5	12	17	1997.821
#340	NKX2-1	5	7	12	344.725
#341	VDR	5	9	14	676.991
#342	TCF12	5	11	16	734.91
#343	FOXN3	5	8	13	733.584
#344	RCAN1	5	8	13	676.941
#345	POU5F1	5	12	17	676.465
#346	MYOD1	5	5	10	81.253
#347	TCF19	5	11	16	1111.392
#348	HNRNPK	5	8	13	368.864
#349	NFE2L3	5	12	17	1163.292
#350	NFIA	5	12	17	1614.378
#351	SRF	5	11	16	2423.151
#352	HMGB1	5	14	19	1229.144
#353	ZXDA	5	7	12	2018.11
#354	E2F7	5	16	21	651.216
#355	FOXA3	5	11	16	454.42
#356	MLXIPL	5	9	14	87.556
#357	EGR1	5	10	15	547.711
#358	ZNF154	5	7	12	662.744
#359	TEAD2	5	13	18	684.902
#360	RBPJ	5	9	14	1086.839
#361	CREBL2	5	11	16	1335.635
#362	GATAD2A	5	14	19	664.297
#363	CITED2	5	10	15	267.316
#364	FOXP1	5	9	14	592.783
#365	HIF3A	5	8	13	275.925
#366	DLX1	5	11	16	1124.78
#367	BCL6	5	13	18	3679.467
#368	NPAT	5	15	20	1012.774
#369	NKX2-8	5	8	13	234.291
#370	EPAS1	5	16	21	827.781
#371	HOPX	5	13	18	2210.847
#372	SOX13	4	7	11	267.423
#373	ELF3	4	9	13	168.756
#374	TBX1	4	5	9	313.781
#375	CNOT8	4	14	18	517.073
#376	TWIST1	4	10	14	758.627
#377	E2F5	4	16	20	3274.805
#378	JDP2	4	13	17	999.368
#379	POU3F3	4	4	8	152.447
#380	TBX10	4	9	13	469.15
#381	NKX6-2	4	9	13	2010.202
#382	NFYA	4	14	18	415.261
#383	NANOGP1	4	12	16	1865.09
#384	XBP1	4	9	13	455.155
#385	SLC30A9	4	16	20	832.106
#386	NFYB	4	10	14	577.839
#387	ETV1	4	10	14	704.228
#388	CREBBP	4	9	13	616.605
#389	KLF9	4	6	10	156.535
#390	PPARA	4	10	14	1268.229
#391	SOX18	4	7	11	129.049
#392	TSC22D3	4	9	13	172.41
#393	HOXB7	4	14	18	2586.413
#394	GLIS2	4	9	13	5280.217
#395	PDX1	4	7	11	3530.526
#396	UHRF1	4	11	15	1609.117
#397	MSRB2	4	11	15	394.323
#398	OTX1	4	10	14	2693.6
#399	CBFA2T2	4	5	9	284.054
#400	SOLH	4	9	13	899.063
#401	HMX2	4	8	12	441.277
#402	MYOG	4	6	10	380.911
#403	SOX5	4	9	13	1789.616
#404	E2F4	4	10	14	402.807
#405	HOXB13	4	9	13	420.741
#406	TP53	4	10	14	988.484
#407	EGR2	4	10	14	1640.414
#408	PAX5	4	9	13	1428.785
#409	CEBPA	4	5	9	325.342
#410	ZNF281	4	11	15	801.963
#411	HMGA2	4	14	18	1274.101
#412	TBX19	4	12	16	1908.927
#413	FOXE3	4	8	12	442.3
#414	CTCF	4	10	14	1249.125
#415	TSC22D4	4	12	16	1008.028
#416	PBX2	4	15	19	1208.094
#417	SMAD5	4	10	14	1099.218
#418	SOX12	4	7	11	920.555
#419	KLF16	3	4	7	24.697
#420	MYT1	3	9	12	106.422
#421	CREB5	3	9	12	606.533
#422	ATF6	3	9	12	1319.809
#423	TFEB	3	15	18	1084.653
#424	CDKN2A	3	14	17	1206.435
#425	SIM2	3	4	7	404.083
#426	SP1	3	10	13	835.243
#427	ETV5	3	10	13	570.145
#428	ZNF33B	3	19	22	1078.04
#429	SIX6	3	10	13	869.902
#430	ETS2	3	10	13	1465.509
#431	SCML2	3	6	9	892.133
#432	SATB1	3	10	13	443.164
#433	KLF6	3	16	19	471.214
#434	FOXK1	3	11	14	512.051
#435	REST	3	10	13	461.686
#436	NRL	3	11	14	1245.411
#437	ZFHX2	3	8	11	384.448
#438	TFDP1	3	10	13	852.147
#439	ATF1	3	18	21	502.989
#440	TCF7L1	3	11	14	1088.889
#441	MNX1	3	9	12	330.852
#442	SPIB	3	7	10	1022.28
#443	HSF4	3	11	14	730.153
#444	TEAD1	3	11	14	3987.571
#445	ZNF134	3	7	10	400.599
#446	REL	3	15	18	1202.446
#447	IRX3	3	8	11	497.759
#448	STAT5A	3	10	13	2538.952
#449	KLF7	3	9	12	195.446
#450	MYF6	2	8	10	247.157
#451	NFIB	2	5	7	815.466
#452	VTN	2	9	11	348.757
#453	LHX1	2	8	10	58.288
#454	HOXC12	2	5	7	167.662
#455	KLF15	2	20	22	1259.623
#456	MYCL1	2	7	9	1127.874
#457	HOXD4	2	3	5	269.047
#458	TCF7L2	2	12	14	933.444
#459	NFE2L2	2	10	12	818.918
#460	MSX1	2	16	18	574.861
#461	TAF5L	2	11	13	1219.034
#462	LCOR	2	16	18	389.656
#463	PLAGL2	2	9	11	221.414
#464	HEY1	2	11	13	441.188
#465	MITF	2	6	8	841.07
#466	HOXB8	2	15	17	133.367
#467	SHOX	2	5	7	1301.168
#468	C2orf3	2	16	18	723.521
#469	LMX1A	2	10	12	121.406
#470	SPEN	2	12	14	232.268
#471	ZFHX3	2	11	13	359.487
#472	ZSCAN2	2	7	9	1750.046
#473	GATAD1	2	13	15	294.9
#474	STAT1	2	14	16	611.311
#475	IRX5	2	17	19	905.145
#476	ZSCAN5A	1	14	15	377.419
#477	HOXA5	1	11	12	1712.642
#478	SMAD1	1	13	14	72.366
#479	RORA	1	8	9	229.727
#480	AFF1	1	6	7	569.787
#481	ARX	1	8	9	645.101
#482	RCOR1	1	15	16	703.907
#483	ZNF175	1	14	15	612.548
#484	FOXO1	1	13	14	287.097
#485	BHLHE40	1	13	14	116.02
#486	IRX1	1	7	8	624.463
#487	PHTF1	1	13	14	246.975
#488	HOXA7	1	13	14	170.223
#489	ESR2	1	6	7	1003.634
#490	BTG2	1	12	13	798.278
#491	TSHZ3	1	11	12	63.893
#492	MSC	1	5	6	945.119
#493	SIX2	1	9	10	298.973
#494	CREM	1	10	11	185.67
#495	FOXJ1	0	16	16	0
#496	FOXD2	0	11	11	0
#497	STAT3	0	6	6	0
#498	ARNTL2	0	12	12	0
#499	ZNF323	0	12	12	0
#500	KDM5B	0	13	13	0