Hub Rank	Node	Children	Parents	Degree	Betweenness
#1	ESRRG	55	3	58	166.659
#2	IRX3	54	2	56	749.114
#3	TEAD4	48	5	53	1615.375
#4	GTF2I	47	5	52	431.69
#5	SP1	46	2	48	62.395
#6	C11orf9	42	1	43	11.719
#7	HOXA10	40	7	47	887.579
#8	CREB1	40	4	44	225.187
#9	ENO1	40	0	40	0
#10	KLF15	38	5	43	1763.238
#11	MAX	38	5	43	1054.387
#12	TAF12	37	5	42	652.188
#13	TWIST1	37	5	42	1128.059
#14	BCL3	34	6	40	945.621
#15	VAV1	33	6	39	799.245
#16	TFAP2A	33	9	42	552.57
#17	STAT1	32	7	39	152.38
#18	JUND	32	8	40	1348.055
#19	PRRX1	32	6	38	836.443
#20	ZFP36L2	30	3	33	335.458
#21	HSF2	29	4	33	113.338
#22	AEBP1	29	4	33	655.366
#23	ZNF277	29	9	38	5427.682
#24	TFCP2L1	28	9	37	1285.584
#25	EHF	27	9	36	884.415
#26	MTA2	27	8	35	579.65
#27	MESP2	26	8	34	311.011
#28	ESRRB	26	7	33	1721.945
#29	FOXM1	26	7	33	257.764
#30	E2F7	26	11	37	3807.745
#31	ZNF169	26	7	33	251.389
#32	ZEB1	26	8	34	1267.666
#33	HHEX	25	10	35	1409.691
#34	NFYA	25	15	40	1017.068
#35	AFF4	25	7	32	1913.981
#36	GABPA	25	5	30	446.134
#37	MYBL2	25	7	32	543.138
#38	FOXA2	24	12	36	3536.417
#39	HOXB7	24	8	32	1792.334
#40	HOXA13	24	5	29	916.289
#41	ERG	23	9	32	2405.19
#42	NKX2-3	23	11	34	2860.715
#43	CREM	23	8	31	500.536
#44	RB1	22	14	36	1048.71
#45	NR1H4	22	12	34	2303.189
#46	KLF2	22	12	34	951.657
#47	ARNTL	22	10	32	722.647
#48	SMAD9	22	13	35	1208.176
#49	RXRG	22	10	32	1951.4
#50	ZGLP1	21	10	31	481.622
#51	HOXB6	21	10	31	1431.568
#52	LZTS1	21	6	27	1692.8
#53	ZNF75D	21	9	30	334.155
#54	SOX4	21	9	30	719.099
#55	NEUROD1	21	14	35	1581.672
#56	EGR2	20	8	28	738.722
#57	MEOX2	20	10	30	1051.927
#58	CBFB	20	11	31	1004.566
#59	HNF4A	20	7	27	774.766
#60	TFEC	20	8	28	1319.415
#61	ZNF202	20	16	36	1427.399
#62	GATAD2A	20	11	31	1502.103
#63	TAF1B	20	11	31	1178.469
#64	HOXA11	20	5	25	569.036
#65	TFAP2C	20	12	32	1340.134
#66	SOX2	20	15	35	2758.656
#67	SIX1	19	11	30	1227.599
#68	ARX	19	20	39	2532.289
#69	JUNB	19	8	27	566.204
#70	BHLHE40	19	13	32	888.253
#71	NR1I2	19	7	26	722.896
#72	LASS6	19	9	28	648.454
#73	NR2F6	19	8	27	682.001
#74	SREBF1	19	6	25	163.757
#75	RERE	19	8	27	994.094
#76	MMP14	19	8	27	2012.17
#77	RXRB	19	12	31	505.735
#78	HES6	19	10	29	1508.845
#79	HSF1	19	5	24	745.696
#80	IRF6	19	12	31	1235.87
#81	BCL6	18	16	34	2231.2
#82	SATB2	18	6	24	122.057
#83	MAFK	18	11	29	2671.769
#84	ZIC2	18	11	29	1026.123
#85	ZNF45	18	11	29	954.983
#86	FOSL2	18	11	29	841.326
#87	PKNOX1	18	11	29	531.249
#88	TRPS1	18	12	30	3399.818
#89	KLF12	18	11	29	2543.228
#90	CUX2	17	12	29	956.174
#91	SMAD5	17	19	36	2049.173
#92	HMGA1	17	8	25	233.447
#93	HOXC9	17	13	30	2168.667
#94	HIC1	17	13	30	752.034
#95	HOXC10	17	12	29	1053.56
#96	SNAPC4	17	11	28	3359.456
#97	NR4A2	17	8	25	1037.676
#98	ASCL2	17	12	29	2681.865
#99	L3MBTL4	16	11	27	2628.053
#100	PHF1	16	11	27	665.162
#101	SUPT6H	16	13	29	787.994
#102	MEIS1	16	12	28	1288.111
#103	TCF3	16	6	22	477.878
#104	ZNF174	16	10	26	733.149
#105	HOXA9	16	13	29	523.163
#106	MZF1	16	14	30	767.768
#107	ZKSCAN1	16	15	31	1198.131
#108	PRDM2	15	10	25	1480.704
#109	ATF3	15	9	24	7346.643
#110	NR5A2	15	14	29	1748.603
#111	GLIS3	15	12	27	1549.486
#112	RFXAP	15	12	27	1553.053
#113	SPI1	15	17	32	1223.84
#114	SOX30	15	11	26	1627.258
#115	ARNT2	15	12	27	1593.926
#116	RCAN1	15	13	28	2760.696
#117	FOSL1	15	7	22	642.489
#118	TRIM29	15	17	32	1391.621
#119	MNX1	15	15	30	2186.487
#120	ATF5	15	14	29	1390.996
#121	KLF16	15	10	25	393.226
#122	SALL1	15	10	25	1585.281
#123	NFE2L2	15	15	30	3242.608
#124	GATA4	15	11	26	1182.105
#125	HOXD11	15	11	26	1272.775
#126	FOXA3	14	6	20	1353.267
#127	GATA5	14	13	27	490.925
#128	RUNX1T1	14	7	21	1124.647
#129	ERF	14	10	24	1893.316
#130	CREB3L3	14	12	26	787.722
#131	TP53	14	12	26	1060.678
#132	THRB	14	15	29	1138.92
#133	BACH1	14	11	25	3398.801
#134	CDX2	14	7	21	422.067
#135	FOS	14	13	27	1544.055
#136	NOTCH1	14	11	25	1412.952
#137	TULP4	14	13	27	1340.014
#138	HIF3A	14	10	24	1497.083
#139	MSX2	14	14	28	672.232
#140	ZNF444	14	15	29	1621.054
#141	GLI2	14	12	26	1693.417
#142	MLL	14	11	25	1018.419
#143	RORC	14	14	28	948.954
#144	TFDP1	14	12	26	893.45
#145	NR0B1	14	12	26	2294.344
#146	TSC22D3	14	10	24	975.449
#147	GTF2H2	14	11	25	1903.298
#148	GABPB1	13	15	28	1342.143
#149	CSRNP3	13	10	23	398.619
#150	ONECUT1	13	10	23	1278.164
#151	NFIC	13	13	26	815.624
#152	TFE3	13	11	24	391.024
#153	FEV	13	8	21	1205.146
#154	ZNF167	13	10	23	902.725
#155	ZEB2	13	8	21	659.371
#156	SIM1	13	14	27	1751.227
#157	CREB3L1	13	10	23	817.398
#158	FOXC1	13	13	26	567.059
#159	POU1F1	13	17	30	3265.474
#160	GATA1	13	12	25	1423.79
#161	FOXD1	13	12	25	651.072
#162	NPAT	13	10	23	1294.484
#163	SMAD4	13	11	24	1089.011
#164	TEAD2	13	15	28	1341.47
#165	MYF5	13	13	26	1393.726
#166	ZBTB48	13	16	29	2961.86
#167	RARB	13	15	28	3013.993
#168	TFAP2B	13	16	29	1216.866
#169	TBX3	13	12	25	1507.444
#170	EGR4	12	17	29	979.626
#171	PROX1	12	11	23	1296.201
#172	ONECUT3	12	14	26	1041.615
#173	HCFC1	12	15	27	1739.02
#174	NFIX	12	10	22	753.042
#175	HEY1	12	9	21	457.641
#176	BNC1	12	13	25	1644.812
#177	ZKSCAN3	12	9	21	1562.247
#178	TCF20	12	15	27	1067.023
#179	FOXN4	12	16	28	1497.157
#180	RFX3	12	9	21	1122.513
#181	MITF	12	13	25	2056.301
#182	SCAND3	12	14	26	1552.994
#183	EN2	12	9	21	388.909
#184	PITX1	12	11	23	564.706
#185	SP3	12	13	25	1002.039
#186	NFKB2	12	14	26	874.474
#187	E2F2	12	5	17	137.88
#188	TCF21	12	12	24	989.614
#189	WNT5A	12	12	24	1990.797
#190	IRX2	12	20	32	1647.984
#191	DLX4	12	14	26	3332.065
#192	LEF1	12	16	28	1312.739
#193	STRN3	12	10	22	1079.673
#194	SMAD3	12	12	24	615.773
#195	C12orf28	12	9	21	1157.799
#196	HOXA1	12	14	26	1107.057
#197	HOXB13	12	12	24	933.934
#198	MYNN	12	12	24	3381.603
#199	FOXH1	12	16	28	1600.771
#200	ZIC1	11	10	21	754.781
#201	ONECUT2	11	10	21	234.825
#202	ST18	11	13	24	1021.055
#203	AHCTF1	11	13	24	741.224
#204	ETV4	11	16	27	1612.604
#205	NR4A3	11	7	18	613.901
#206	SPDEF	11	12	23	2368.245
#207	SOX21	11	8	19	503.595
#208	SCAND1	11	11	22	1209.616
#209	ESR2	11	12	23	1980.642
#210	SMAD1	11	13	24	1808.778
#211	BACH2	11	12	23	1282.016
#212	HOXD10	11	12	23	1324.986
#213	TSC22D1	11	12	23	1641.05
#214	VENTX	11	11	22	1455.71
#215	NOBOX	11	10	21	989.552
#216	BLZF1	11	12	23	1216.552
#217	NR6A1	11	12	23	1138.24
#218	LMO4	11	18	29	3293.145
#219	POU3F4	11	12	23	1981.754
#220	STAT6	11	13	24	1384.189
#221	ZNF155	11	14	25	1327.543
#222	ZNF483	11	14	25	2101.539
#223	CSDA	10	13	23	541.975
#224	TEF	10	8	18	514.387
#225	ASCL1	10	15	25	402.604
#226	ETV6	10	12	22	1324.987
#227	PBX1	10	14	24	923.261
#228	ZNF3	10	13	23	1303.909
#229	ZNF193	10	18	28	1989.356
#230	HOXB9	10	12	22	1204.854
#231	PRRX2	10	19	29	2412.267
#232	HOXB2	10	10	20	786.794
#233	PBX3	10	16	26	792.388
#234	ZNF238	10	12	22	267.765
#235	ZSCAN4	10	16	26	1862.597
#236	VDR	10	13	23	909.029
#237	KDM5B	10	8	18	745.384
#238	HOXA7	10	12	22	1408.408
#239	POU2F2	10	9	19	838.488
#240	TSHZ2	10	13	23	1242.164
#241	HOXB3	10	12	22	1636.587
#242	POU2F3	10	12	22	1178.515
#243	HIRA	10	17	27	2767.067
#244	ZNF19	10	17	27	2181.725
#245	ZNF117	10	13	23	1132.257
#246	RARA	10	8	18	1282.865
#247	HOXD4	10	11	21	1041.473
#248	TGIF1	10	10	20	644.171
#249	KDM5A	10	10	20	1072.705
#250	NKX3-2	10	11	21	1482.442
#251	SPEN	10	16	26	1285.265
#252	ZSCAN2	10	9	19	1000.226
#253	NFATC2	10	15	25	1820.579
#254	ZNF396	10	14	24	773.278
#255	FOXP2	10	13	23	1667.277
#256	TBR1	10	12	22	1792.66
#257	TAF13	9	10	19	797.687
#258	HOXD9	9	12	21	952.527
#259	POU6F2	9	13	22	1393.279
#260	SLC26A3	9	12	21	703.58
#261	LHX9	9	14	23	2335.483
#262	TLX3	9	11	20	808.964
#263	HNF4G	9	12	21	466.402
#264	IRX5	9	14	23	1275.277
#265	SMAD2	9	12	21	410.033
#266	TFDP2	9	12	21	547.431
#267	RELA	9	13	22	1180.329
#268	CREBBP	9	11	20	2152.81
#269	ZNF80	9	13	22	1176.409
#270	FOXS1	9	14	23	362.998
#271	PKNOX2	9	11	20	1473.15
#272	NR4A1	9	12	21	950.748
#273	FOXA1	9	14	23	987.841
#274	BHLHE41	9	14	23	501.286
#275	FOXO1	9	12	21	562.454
#276	HMGB2	9	13	22	1519.469
#277	TCF15	9	15	24	731.624
#278	HOXA4	9	12	21	1695.576
#279	SOX13	9	14	23	1548.168
#280	NFE2	9	12	21	1756.173
#281	ZIC3	9	16	25	2347.633
#282	TFAP4	9	14	23	2066.808
#283	CBFA2T2	9	10	19	1445.173
#284	ISX	9	14	23	1267.308
#285	TCF12	9	13	22	945.85
#286	PHOX2B	9	12	21	1888.125
#287	NFIB	9	14	23	2066.565
#288	FOXD2	9	14	23	1231.55
#289	ZNF85	9	11	20	887.222
#290	MYCN	9	13	22	637.537
#291	FOXL2	9	12	21	1783.548
#292	FOXK1	9	12	21	2093.633
#293	HR	9	13	22	1482.742
#294	MECOM	9	11	20	960.977
#295	PAX7	9	12	21	1105.922
#296	IKZF1	9	14	23	981.851
#297	SOX6	9	16	25	1283.209
#298	ELF5	9	10	19	434.638
#299	FOXB1	9	9	18	1008.867
#300	ZNF134	8	13	21	523.152
#301	ZNF287	8	14	22	1864.953
#302	SPIB	8	15	23	1074.278
#303	MESP1	8	17	25	1263.329
#304	NANOGNB	8	12	20	1435.721
#305	SNAPC5	8	11	19	1380.101
#306	ZRANB2	8	10	18	479.72
#307	TEAD1	8	12	20	970.224
#308	ZNF41	8	15	23	498.088
#309	PAX8	8	13	21	1392.33
#310	PPARD	8	15	23	710.307
#311	TBX1	8	12	20	829.495
#312	SLC2A4RG	8	16	24	1164.586
#313	ZNF131	8	14	22	1635.414
#314	NPAS2	8	15	23	1549.856
#315	HOXB8	8	18	26	1013.357
#316	ZNF93	8	11	19	587.589
#317	ZFP42	8	10	18	1245.01
#318	SP140	8	13	21	613.226
#319	MXD1	8	15	23	416.721
#320	ZNF90	8	11	19	820.914
#321	CREB3L2	8	14	22	866.749
#322	CITED1	8	15	23	767.354
#323	ZNF496	8	15	23	1209.575
#324	SPIC	8	17	25	949.169
#325	PHOX2A	8	9	17	606.117
#326	ISL2	8	15	23	928.292
#327	HOXC5	8	17	25	3090.937
#328	ZBTB25	8	12	20	474.731
#329	FOXO3	8	17	25	1032.779
#330	VTN	8	14	22	1053.028
#331	MYT1	8	12	20	1819.974
#332	GATAD1	8	11	19	973.958
#333	PGR	8	10	18	950.229
#334	THRA	8	18	26	2015.668
#335	ETV1	8	13	21	1616.77
#336	ZNF81	7	12	19	766.573
#337	ZSCAN1	7	14	21	937.024
#338	FOXD3	7	9	16	869.733
#339	HMG20B	7	12	19	1033.535
#340	GSX1	7	15	22	1124.918
#341	TBX5	7	9	16	854.616
#342	ATOH1	7	11	18	1041.166
#343	POU3F1	7	13	20	740.648
#344	SIN3A	7	11	18	1066.124
#345	RUNX1	7	12	19	1121.021
#346	SIM2	7	10	17	765.388
#347	TAL1	7	10	17	434.945
#348	HES5	7	12	19	930.387
#349	FLI1	7	13	20	904.169
#350	PAX3	7	13	20	934.152
#351	ZNF639	7	7	14	810.048
#352	SCAND2	7	14	21	930.031
#353	ZNF83	7	13	20	1157.546
#354	ZIC5	7	14	21	618.786
#355	HNF1A	7	14	21	729.864
#356	EPAS1	7	13	20	818.197
#357	NR1I3	7	10	17	589.458
#358	HOPX	7	12	19	567.964
#359	ETV5	7	12	19	580.736
#360	OLIG2	7	12	19	1129.242
#361	MYT1L	7	12	19	710.615
#362	RORB	7	13	20	1221.112
#363	ZFHX2	7	13	20	2123.724
#364	GSC2	7	11	18	1308.63
#365	IRF4	7	16	23	1029.157
#366	OTX2	7	11	18	1363.31
#367	EMX1	7	12	19	1061.586
#368	IRX4	7	11	18	908.419
#369	TBX6	7	12	19	913.53
#370	USF1	7	11	18	430.347
#371	TLX2	7	9	16	815.544
#372	MAF	7	15	22	1147.396
#373	CBL	7	17	24	671.299
#374	ZNF449	7	12	19	957.663
#375	MLLT10	7	13	20	792.479
#376	PCGF2	7	10	17	906.694
#377	PDX1	7	14	21	885.52
#378	CDKN2A	7	16	23	1114.714
#379	GATA3	7	15	22	1223.531
#380	ZNF434	7	11	18	1872.269
#381	PAX6	6	16	22	896.026
#382	SOX8	6	14	20	880.649
#383	SOX15	6	9	15	568.489
#384	SOX5	6	13	19	1003.647
#385	MKX	6	15	21	846.54
#386	MAFG	6	9	15	449.703
#387	ZFHX4	6	13	19	1076.168
#388	TBX20	6	10	16	375.788
#389	LHX1	6	16	22	1010.634
#390	ATF6B	6	13	19	985.654
#391	LHX8	6	17	23	919.262
#392	NFYC	6	13	19	1140.956
#393	TP63	6	16	22	1136.209
#394	PLSCR1	6	15	21	974.253
#395	PAX4	6	13	19	843.685
#396	ZNF154	6	11	17	828.788
#397	TP73	6	12	18	405.056
#398	GCFC1	6	11	17	487.096
#399	ZHX2	6	14	20	1108.93
#400	SOX11	6	11	17	430.947
#401	HSF5	6	17	23	1025.706
#402	OTX1	6	11	17	1527.763
#403	RUNX2	6	11	17	627.605
#404	FOXI1	6	15	21	471.04
#405	NEUROG1	6	16	22	512.073
#406	NR2E3	6	14	20	636.747
#407	ZNF92	6	11	17	407.043
#408	NFIA	6	9	15	884.925
#409	WT1	6	11	17	332.056
#410	FOSB	6	12	18	406.368
#411	ZBTB38	6	10	16	739.776
#412	MYF6	6	10	16	507.65
#413	RCOR1	6	11	17	418.568
#414	ZFHX3	6	11	17	958.292
#415	BRD8	6	17	23	1997.451
#416	LHX4	6	14	20	1000.071
#417	ESR1	6	14	20	1826.342
#418	TBX2	6	13	19	547.032
#419	FOXC2	6	14	20	718.446
#420	ARNTL2	6	14	20	876.383
#421	ALX3	6	11	17	1187.2
#422	NRL	6	12	18	822.685
#423	ELK1	6	11	17	420.223
#424	PURB	6	8	14	334.143
#425	NPAS1	6	16	22	819.653
#426	HLF	5	18	23	681.978
#427	ZNF446	5	14	19	890.402
#428	ZNF215	5	17	22	1166.432
#429	SEBOX	5	13	18	609.358
#430	ZNF24	5	9	14	461.455
#431	ZNF192	5	12	17	1040.554
#432	CTBP1	5	12	17	621.908
#433	FOXP3	5	12	17	605.22
#434	NFAT5	5	15	20	706.561
#435	VSX1	5	13	18	671.044
#436	ATF7	5	14	19	1087.741
#437	ZNF643	5	11	16	594.941
#438	NFATC4	5	16	21	604.34
#439	KCNH8	5	18	23	797.193
#440	MGA	5	17	22	1148.559
#441	DLX6	5	11	16	1468.249
#442	SOX1	5	14	19	867.372
#443	TBX22	5	11	16	515.828
#444	EBF1	5	13	18	663.083
#445	ELK4	5	10	15	425.342
#446	SIX3	5	10	15	1239.572
#447	RUNX3	5	12	17	321.902
#448	HOXD13	5	13	18	606.453
#449	POU3F2	5	11	16	534.512
#450	PPARA	5	12	17	732.577
#451	DLX1	5	16	21	1566.684
#452	POU5F2	5	12	17	522.425
#453	HOXD3	5	11	16	538.43
#454	LMX1A	5	11	16	517.157
#455	HMGA2	4	21	25	1078.486
#456	CREBZF	4	14	18	491.512
#457	NANOG	4	12	16	290.149
#458	POU4F1	4	11	15	400.063
#459	MLXIPL	4	13	17	1564.732
#460	KLF9	4	11	15	342.909
#461	ZNF397	4	10	14	445.74
#462	IKZF3	4	14	18	468.125
#463	POU2F1	4	14	18	845.565
#464	HOXD1	4	14	18	670.317
#465	FOXP1	4	14	18	675.155
#466	DMRT2	4	17	21	1035.115
#467	ZNF71	4	16	20	402.255
#468	SMAD6	4	14	18	593.699
#469	FOXE1	4	10	14	780.623
#470	HOXA2	4	10	14	636.6
#471	TADA3	4	13	17	401.079
#472	SIX4	3	17	20	603.358
#473	HDX	3	12	15	894.814
#474	ESX1	3	10	13	303.522
#475	OVOL1	3	14	17	518.795
#476	SIX6	3	11	14	367.327
#477	ATF2	3	14	17	342.354
#478	HNRNPAB	3	12	15	881.397
#479	DMBX1	3	12	15	260.174
#480	RARG	3	15	18	438.091
#481	BCL11B	3	16	19	974.153
#482	ZSCAN23	3	14	17	494.717
#483	NEUROD2	3	9	12	212.384
#484	CLOCK	3	12	15	260.419
#485	PGBD1	3	12	15	292.95
#486	ZXDC	3	11	14	145.494
#487	ZFP36L1	3	7	10	314.233
#488	ZNF157	3	13	16	423.981
#489	LHX2	2	15	17	754.956
#490	PTH	2	16	18	462.711
#491	ZNF132	2	11	13	154.191
#492	ALS2CR8	2	15	17	321.309
#493	NKX6-2	2	11	13	236.486
#494	FOXL1	1	12	13	83.276
#495	ZNF207	1	15	16	151.29
#496	TSC22D2	1	13	14	131.546
#497	ARNT	1	15	16	100.586
#498	RORA	1	14	15	178.817
#499	ZSCAN20	0	10	10	0
#500	ANKRD30A	0	13	13	0