Hub Rank	Node	Children	Parents	Degree	Betweenness
#1	ZNF33B	102	0	102	0
#2	HOXA2	84	7	91	1382.942
#3	ETS1	76	5	81	1025.965
#4	ZNF169	76	2	78	675.301
#5	ZSCAN10	60	4	64	1042.276
#6	TWIST2	58	4	62	81.643
#7	IRF6	57	5	62	386.899
#8	SUPT6H	56	7	63	579.736
#9	MLX	54	10	64	781.024
#10	BNC1	54	4	58	2181.246
#11	CTNNB1	51	9	60	549.646
#12	KLF7	50	9	59	1399.531
#13	ZEB1	48	10	58	1097.645
#14	FOSL1	48	6	54	1097.411
#15	MLL	47	13	60	1785.883
#16	ZNF496	47	12	59	2566.027
#17	ZNF396	47	10	57	1118.909
#18	ETV4	47	17	64	3771.091
#19	STAT5B	46	8	54	10925.651
#20	SOX4	44	2	46	10.837
#21	SP1	44	9	53	685.956
#22	ZEB2	44	8	52	530.25
#23	FOXO1	43	14	57	2763.208
#24	TFE3	42	10	52	566.682
#25	SOX7	40	8	48	826.272
#26	FOXC1	39	17	56	2243.964
#27	ZSCAN1	39	13	52	2238.781
#28	ZNF277	39	5	44	1304.441
#29	HOXA3	39	5	44	335.666
#30	TGIF1	38	7	45	2150.311
#31	CNOT7	38	11	49	1111.51
#32	RAX2	37	9	46	260.067
#33	KLF17	36	9	45	1303.033
#34	KLF11	35	10	45	2171.295
#35	HOXA9	35	12	47	2827.512
#36	MYNN	35	8	43	344.097
#37	FOXN4	35	11	46	2018.155
#38	GCFC1	34	8	42	752.984
#39	TRIM29	34	11	45	1549.562
#40	HOXA5	34	8	42	484.317
#41	HOXA1	34	4	38	194.972
#42	FOXR2	33	10	43	683.998
#43	HMGA2	33	10	43	2484.56
#44	FOXF2	33	9	42	1978.213
#45	TEAD1	33	16	49	3008.297
#46	SNAI2	32	15	47	2231.666
#47	SREBF1	32	14	46	992.916
#48	NFYC	32	9	41	802.814
#49	SOX13	31	20	51	5057.954
#50	NEUROD1	31	16	47	752.287
#51	ETS2	31	11	42	1154.845
#52	AHCTF1	31	7	38	1758.493
#53	ZNF207	31	13	44	1187.36
#54	ZNF92	30	13	43	1654.687
#55	ZNF446	30	11	41	9879.223
#56	GATA3	30	14	44	6585.605
#57	PPARA	30	17	47	3200.415
#58	ZNF75D	30	9	39	540.096
#59	SMAD6	29	7	36	187.115
#60	SOX5	29	12	41	4852.288
#61	PRDM1	29	10	39	670.711
#62	TSC22D4	29	7	36	977.78
#63	GATA1	29	12	41	2348.113
#64	RHOXF1	28	9	37	1466.776
#65	GATA4	28	9	37	1183.338
#66	KLF6	28	11	39	784.546
#67	FLI1	28	8	36	454.246
#68	MYT1	28	16	44	9444.033
#69	MEF2C	27	11	38	2818.629
#70	SLC2A4RG	27	7	34	735.996
#71	TAF5L	27	11	38	1044.806
#72	FOXA2	26	11	37	3220.78
#73	KLF2	26	16	42	1727.239
#74	ZNF131	26	14	40	937.515
#75	FOXA1	25	8	33	646.064
#76	MESP2	25	9	34	379.93
#77	TAL1	25	12	37	739.847
#78	ZBTB38	25	11	36	512.253
#79	SPDEF	24	5	29	228.22
#80	CREB3L4	24	6	30	994.38
#81	CTBP1	24	10	34	194.757
#82	EBF1	24	7	31	721.255
#83	ZKSCAN3	24	15	39	472.744
#84	ZNF85	23	16	39	790.925
#85	MAFB	23	16	39	5216.889
#86	TRPS1	23	11	34	1837.805
#87	HOXD4	23	16	39	2746.073
#88	ZNF80	23	9	32	359.062
#89	ATF6B	23	11	34	7322.85
#90	SP140	23	12	35	2364.235
#91	FOXD4	23	13	36	1547.345
#92	LZTS1	23	16	39	1533.003
#93	SOX30	23	13	36	1199.902
#94	SMAD4	23	17	40	1940.405
#95	HOXC12	23	19	42	1212.817
#96	NEUROD2	22	11	33	1858.54
#97	MSX1	22	15	37	7021.074
#98	FOXJ2	22	17	39	5755.319
#99	PBX1	21	19	40	4429.777
#100	ZKSCAN1	21	15	36	639.331
#101	ZNF483	21	16	37	704.865
#102	CCRN4L	21	11	32	439.907
#103	SOX15	21	12	33	2477.695
#104	HDX	21	15	36	3767.087
#105	FOXQ1	21	14	35	3888.501
#106	ZNF91	21	12	33	2314.207
#107	ZNF628	20	9	29	189.706
#108	C1orf85	20	10	30	1072.12
#109	CBFA2T2	20	9	29	163.683
#110	ZNF24	20	17	37	514.659
#111	ZNF93	20	12	32	908.391
#112	HOXA10	20	10	30	677.091
#113	MBD1	20	8	28	391.933
#114	L3MBTL4	19	10	29	836.37
#115	TSHZ3	19	20	39	1096.794
#116	SOX9	19	16	35	2062.502
#117	FOXO6	19	15	34	385.03
#118	ELF3	19	10	29	571.481
#119	ZNF41	19	9	28	145.449
#120	ELF4	18	14	32	907.91
#121	NFE2L2	18	7	25	178.111
#122	CSRNP3	18	18	36	2239.584
#123	HOXB2	18	11	29	3687.756
#124	MLLT10	18	3	21	9.73
#125	BLZF1	18	18	36	472.233
#126	TRIM22	18	14	32	2260.321
#127	MECOM	18	19	37	9296.77
#128	HOXA4	18	7	25	364.45
#129	SOX17	17	11	28	1573.464
#130	DLX6	17	15	32	5406.569
#131	PAX7	17	13	30	638.914
#132	TAF5	17	11	28	231.567
#133	MMP14	17	14	31	515.944
#134	ETV3	17	11	28	369.421
#135	TCF4	17	11	28	301.831
#136	SOX8	17	17	34	5491.796
#137	CREM	16	14	30	8360.129
#138	JUN	16	11	27	276.36
#139	C12orf28	16	15	31	1943.817
#140	IRF8	16	6	22	270.157
#141	ZNF70	16	7	23	345.668
#142	ZNF90	16	14	30	6366.006
#143	GLI3	16	19	35	3186.059
#144	PBX4	16	16	32	3078.778
#145	FOXP1	16	12	28	2483.721
#146	ZNF167	16	12	28	274.029
#147	RUNX3	16	17	33	1048.719
#148	TBX3	15	15	30	1791.076
#149	ESR2	15	17	32	841.759
#150	ISL1	15	15	30	3706.634
#151	C5orf41	15	11	26	317.482
#152	ALX1	15	14	29	4633.688
#153	AFF4	15	8	23	890.337
#154	HOXB7	15	14	29	1726.643
#155	SALL1	15	16	31	3098.716
#156	TP63	15	9	24	441.43
#157	ZNF81	14	14	28	13631.773
#158	GBX2	14	15	29	2813.296
#159	EGR3	14	12	26	1714.654
#160	ATF1	14	7	21	105.492
#161	POU3F3	14	8	22	353.344
#162	CREB5	14	18	32	1354.193
#163	FOXD1	14	12	26	434.827
#164	FOXG1	14	19	33	13600.495
#165	BHLHE40	14	7	21	68.895
#166	ATF3	14	10	24	833.456
#167	ZSCAN20	14	12	26	1050.457
#168	ETV1	13	20	33	1174.003
#169	TFCP2L1	13	14	27	519.429
#170	KCNH8	13	17	30	4825.425
#171	HCLS1	13	9	22	346.989
#172	ZNF397	13	18	31	525.629
#173	ARNTL2	13	23	36	2843.579
#174	SIM2	13	19	32	2361.282
#175	HOXC10	13	11	24	474.355
#176	KLF5	13	15	28	2158.931
#177	ANKRD30A	13	12	25	781.964
#178	NR5A2	13	12	25	987.155
#179	C11orf9	13	11	24	578.965
#180	HIF3A	13	10	23	417.946
#181	POU5F2	13	5	18	598.246
#182	LASS5	13	14	27	410.61
#183	HOXB13	13	16	29	2525.527
#184	HMGA1	13	17	30	1107.796
#185	TARDBP	13	14	27	467.131
#186	RARA	13	16	29	986.765
#187	LHX4	13	10	23	641.776
#188	ZHX2	12	20	32	708.562
#189	MEIS1	12	18	30	3207.809
#190	SPEN	12	6	18	103.807
#191	DMBX1	12	16	28	801.579
#192	GRHL2	12	10	22	222.656
#193	CEBPD	12	13	25	3343.534
#194	NFX1	12	13	25	314.956
#195	HOXA13	12	13	25	1288.622
#196	ZFPM2	12	17	29	1878.843
#197	TEAD2	12	15	27	853.583
#198	ASCL2	12	19	31	3705.442
#199	DLX3	12	14	26	257.176
#200	POU4F1	12	12	24	2415.054
#201	LEF1	12	22	34	2919.122
#202	TAF4	12	11	23	1637.688
#203	EN1	12	12	24	2115.168
#204	TP73	12	21	33	1339.798
#205	ESRRG	12	15	27	2307.539
#206	PROX1	12	12	24	3596.006
#207	RORA	11	18	29	2435.1
#208	POU2F1	11	12	23	1257.694
#209	ZSCAN2	11	14	25	1268.4
#210	IRX4	11	15	26	2722.959
#211	SIM1	11	20	31	6358.939
#212	PAX6	11	16	27	1980.79
#213	MYT1L	11	16	27	4312.893
#214	ZIC2	11	9	20	813.008
#215	ZNF117	11	11	22	1244.114
#216	TCF12	11	10	21	283.532
#217	HIC1	11	15	26	703.535
#218	REST	11	11	22	193.588
#219	ISL2	11	19	30	6910.912
#220	ZIC5	11	18	29	642.73
#221	MITF	11	9	20	1811.688
#222	IRX1	11	15	26	1717.393
#223	HOXA7	11	17	28	1395.045
#224	ESRRB	10	12	22	274.427
#225	HOXD10	10	16	26	438.775
#226	NR3C1	10	14	24	2105.258
#227	HHEX	10	18	28	948.9
#228	ELK4	10	19	29	559.958
#229	GLIS3	10	13	23	532.636
#230	BTG2	10	12	22	1342.241
#231	AR	10	12	22	1662.882
#232	MEIS2	10	14	24	1861.158
#233	CSDA	10	14	24	1525.675
#234	NFATC1	10	10	20	835.255
#235	RUNX1T1	10	10	20	977.906
#236	TBX2	10	15	25	1962.431
#237	ERG	9	11	20	456.13
#238	BHLHE41	9	20	29	994.461
#239	AEBP1	9	11	20	459.416
#240	SMAD9	9	14	23	2041.997
#241	MGA	9	23	32	2088.586
#242	CDKN2A	9	17	26	3109.618
#243	LHX8	9	17	26	5879.98
#244	TBX20	9	14	23	748.78
#245	PPARG	9	15	24	1370.749
#246	ZNF287	9	17	26	1150.881
#247	ARX	9	14	23	1432.139
#248	TFEC	9	11	20	332.507
#249	ZSCAN12	9	16	25	5511.637
#250	EMX1	9	13	22	1116.48
#251	SNAPC5	9	12	21	175.571
#252	POU2F3	9	18	27	167.054
#253	TSHZ2	9	17	26	7195.959
#254	SMAD1	9	8	17	259.883
#255	FOS	9	14	23	371.297
#256	LMX1B	9	14	23	991.273
#257	PRRX1	9	9	18	118.589
#258	IRX5	9	14	23	1160.824
#259	CEBPA	9	12	21	555.007
#260	EGR2	9	15	24	891.266
#261	SOX11	9	15	24	1370.495
#262	PGBD1	9	15	24	846.252
#263	SMAD2	8	14	22	2087.918
#264	ZSCAN18	8	15	23	782.084
#265	MAFF	8	15	23	491.439
#266	ESX1	8	15	23	1194.405
#267	ZNF83	8	10	18	3012.468
#268	TLX2	8	5	13	454.291
#269	IKZF1	8	13	21	530.01
#270	ETV5	8	17	25	735.284
#271	BATF	8	13	21	535.095
#272	HOXA11	8	15	23	3959.936
#273	POU6F1	8	14	22	696.535
#274	IRF7	8	11	19	904.523
#275	ZSCAN23	8	17	25	334.471
#276	SNAI3	8	16	24	349.471
#277	PRRX2	8	17	25	1016.583
#278	HOXC13	8	12	20	2395.232
#279	OVOL1	7	17	24	5862.094
#280	EGR1	7	18	25	951.65
#281	GATAD2A	7	19	26	1558.594
#282	IRF9	7	12	19	933.082
#283	MAF	7	14	21	1272.055
#284	FOXP2	7	15	22	486.719
#285	GAS7	7	19	26	339.249
#286	ATF2	7	15	22	4312.8
#287	SOX6	7	18	25	488.377
#288	GATA5	7	18	25	1877.814
#289	HEY1	7	20	27	459.85
#290	FUBP1	7	17	24	790.158
#291	MESP1	7	19	26	955.728
#292	MSC	7	16	23	609.071
#293	NANOGNB	7	14	21	1532.805
#294	PLAG1	7	17	24	2812.041
#295	GSX1	7	19	26	660.378
#296	SIX3	7	12	19	1260.485
#297	RB1	7	12	19	1912.415
#298	NFIA	7	19	26	2084.634
#299	SATB2	7	14	21	715.082
#300	LMO4	7	13	20	1365.695
#301	GLI2	7	12	19	348.107
#302	GRHL3	7	16	23	2709.928
#303	SPIB	7	16	23	816.875
#304	CBFA2T3	7	17	24	1918.332
#305	LHX9	7	18	25	1428.956
#306	TULP4	7	12	19	383.416
#307	KDM5A	7	13	20	1223.704
#308	MEIS3	7	16	23	1612.933
#309	HR	7	15	22	2180.889
#310	NFE2L3	7	16	23	702.687
#311	ST18	7	8	15	67.153
#312	TCF21	7	15	22	344.357
#313	EGR4	7	15	22	1260.197
#314	ENO1	7	15	22	557.621
#315	CUX2	7	19	26	3315.397
#316	NKX6-2	6	15	21	1161.471
#317	ESR1	6	10	16	479.037
#318	MKX	6	16	22	1118.462
#319	NFIX	6	18	24	2814.372
#320	DLX1	6	13	19	1235.234
#321	NFATC4	6	12	18	523.75
#322	MEOX1	6	11	17	260.72
#323	ZNF238	6	20	26	2214.523
#324	EN2	6	13	19	1376.968
#325	FOXL1	6	11	17	896.753
#326	RCOR1	6	18	24	2535.54
#327	ZSCAN4	6	19	25	631.741
#328	TCF7L2	6	11	17	721.453
#329	HOXB3	6	9	15	434.767
#330	ZNF3	6	13	19	900.329
#331	ZNF154	6	11	17	136.103
#332	HES5	6	11	17	1209.853
#333	RARB	6	13	19	486.86
#334	ZFHX4	6	18	24	1807.57
#335	TCF20	6	11	17	131.106
#336	NCOR1	5	7	12	56.327
#337	DLX2	5	16	21	2760.513
#338	SP3	5	15	20	570.025
#339	WNT5A	5	16	21	1387.917
#340	RORC	5	12	17	338.364
#341	ZNF132	5	15	20	394.259
#342	HOPX	5	13	18	287.187
#343	ONECUT2	5	17	22	1877.393
#344	TBX5	5	16	21	857.919
#345	HOXD3	5	14	19	500.482
#346	SPI1	5	9	14	76.579
#347	MEOX2	5	11	16	614.046
#348	NR2F2	5	9	14	407.505
#349	PHOX2B	5	9	14	143.074
#350	FOXO3	5	9	14	291.005
#351	PAX8	5	20	25	1488.323
#352	DMRT2	5	14	19	1116.053
#353	HMG20B	5	12	17	757.047
#354	EVX1	5	8	13	78.914
#355	BCL6	5	15	20	397.966
#356	NR3C2	5	22	27	1651.55
#357	NPAS1	5	14	19	1503.108
#358	KLF9	5	15	20	619.001
#359	NFATC2	5	18	23	1159.349
#360	ARNT	5	12	17	135.058
#361	HEY2	5	19	24	1743.994
#362	NR2F6	5	12	17	357.299
#363	FOXL2	5	18	23	3625.495
#364	SCML1	5	13	18	750.223
#365	SATB1	5	15	20	526.601
#366	RORB	5	11	16	364.953
#367	TFAP2E	4	11	15	545.354
#368	ZNF71	4	10	14	318.824
#369	POU1F1	4	11	15	219.668
#370	E2F8	4	13	17	664.02
#371	PPBPL2	4	11	15	876.519
#372	TFAP2C	4	12	16	468.629
#373	TADA3	4	14	18	685.783
#374	NR2F1	4	18	22	461.064
#375	FOXJ1	4	16	20	1037.332
#376	GATA6	4	11	15	1053.633
#377	TLX3	4	14	18	469.165
#378	MNX1	4	13	17	639.304
#379	PGR	4	12	16	862.231
#380	PITX2	4	18	22	2395.284
#381	SIN3A	4	11	15	219.499
#382	ZIC1	4	23	27	1214.001
#383	VTN	4	13	17	218.827
#384	SLC26A3	4	10	14	385.176
#385	TP53	4	21	25	2754.511
#386	NFAT5	4	16	20	1318.099
#387	ZNF215	4	19	23	1320.637
#388	SMAD3	4	15	19	351.834
#389	KDM5B	4	10	14	230.905
#390	HOXD13	4	15	19	491.758
#391	RUNX2	4	12	16	764.597
#392	POU2F2	4	14	18	97.251
#393	TWIST1	4	27	31	2863.664
#394	FOXA3	4	18	22	1069.651
#395	NPAS2	4	13	17	1419.702
#396	GSC2	4	21	25	747.552
#397	ZNF135	4	10	14	242.648
#398	STAT2	4	14	18	300.174
#399	HES6	4	12	16	1736.607
#400	NR4A2	4	15	19	757.258
#401	EHF	4	14	18	979.11
#402	SOX10	4	8	12	1108.003
#403	STAT6	4	17	21	1575.066
#404	FOSL2	3	13	16	739.927
#405	PAX3	3	20	23	678.971
#406	NKX2-1	3	15	18	1707.763
#407	MXD1	3	12	15	231.744
#408	NANOG	3	9	12	73.168
#409	RERE	3	15	18	489.452
#410	OTX2	3	11	14	57.581
#411	ZFP36L1	3	13	16	1114.493
#412	PLSCR1	3	16	19	1658.322
#413	THRA	3	11	14	269.166
#414	FOXC2	3	16	19	117.268
#415	VAV1	3	14	17	1315.943
#416	POU3F2	3	18	21	2317.004
#417	ATOH1	3	13	16	113.062
#418	NKX2-5	3	18	21	1961.18
#419	PEG3	3	14	17	1141.355
#420	SCAND2	3	10	13	552.697
#421	FOXE1	3	12	15	373.568
#422	KLF12	3	16	19	160.756
#423	NFIB	3	14	17	96.231
#424	HNF4G	3	18	21	1655.629
#425	LHX2	3	25	28	1908.216
#426	RUNX1	3	8	11	67.034
#427	IRX2	3	22	25	379.139
#428	GATAD1	3	15	18	1922.715
#429	VENTX	3	13	16	105.214
#430	ELF5	3	20	23	699.544
#431	ARNT2	3	26	29	2279.332
#432	WT1	3	16	19	1931.096
#433	ETV7	3	14	17	557.468
#434	SOX18	3	16	19	144.291
#435	LHX1	2	18	20	313.485
#436	MYF5	2	10	12	30.63
#437	TBX1	2	21	23	268.039
#438	CITED1	2	15	17	1128.986
#439	PAX4	2	21	23	1464.873
#440	FOXP4	2	12	14	217.243
#441	VSX1	2	15	17	253.488
#442	PITX1	2	15	17	319.031
#443	SIX1	2	13	15	122.659
#444	MSRB2	2	17	19	156.526
#445	DMRT1	2	10	12	49.234
#446	STRN3	2	17	19	889.074
#447	EPAS1	2	13	15	941.88
#448	TCF7	2	16	18	920.694
#449	HLF	2	18	20	744.397
#450	NR1H4	2	12	14	362.379
#451	KLF15	2	19	21	227.721
#452	TFAP2A	2	11	13	632.367
#453	BCL11B	2	24	26	376.779
#454	ZIC3	2	11	13	339.568
#455	NR4A3	2	14	16	596.248
#456	BACH2	2	12	14	103.883
#457	HOXD11	2	16	18	132.965
#458	FOXD3	2	17	19	228.743
#459	ZFP42	2	17	19	375.666
#460	MYCN	2	16	18	378.281
#461	PKNOX2	2	16	18	381.534
#462	CREB3L3	2	10	12	60.836
#463	BARX1	2	17	19	307.307
#464	MTA2	1	13	14	240.43
#465	MSX2	1	16	17	453.436
#466	RARG	1	13	14	2764.28
#467	HOXB6	1	12	13	944.25
#468	TFCP2	1	12	13	91.348
#469	ASCL1	1	10	11	98.484
#470	PPARD	1	14	15	117.909
#471	POU3F1	1	13	14	115.035
#472	IKZF3	1	14	15	1195.959
#473	NR0B1	1	18	19	253.613
#474	SOX2	1	15	16	48.575
#475	ZXDC	1	10	11	10.915
#476	LHX6	1	14	15	20.741
#477	C2orf3	1	15	16	97.022
#478	CREBZF	1	14	15	91.531
#479	TEF	1	15	16	786.696
#480	NRL	1	15	16	37.037
#481	ZFP36L2	1	12	13	230.509
#482	MLXIPL	1	8	9	717.411
#483	HSF5	1	11	12	62.25
#484	NEUROG1	1	15	16	109.374
#485	HOXD1	1	10	11	44.039
#486	ZNF157	1	12	13	156.492
#487	HNRNPAB	1	8	9	19.494
#488	TFAP2B	1	19	20	112.379
#489	CREB3L1	1	15	16	61.961
#490	SOX1	1	19	20	4566.556
#491	TFAP2D	0	15	15	0
#492	ZFHX3	0	15	15	0
#493	NPAT	0	12	12	0
#494	FOXP3	0	18	18	0
#495	IRF1	0	16	16	0
#496	FOXI1	0	8	8	0
#497	HESX1	0	10	10	0
#498	GCM1	0	11	11	0
#499	FOSB	0	10	10	0
#500	TBX22	0	12	12	0