Hub Rank	Node	Children	Parents	Degree	Betweenness
#1	NR1D2	65	4	69	544.319
#2	C11orf9	54	6	60	2657.798
#3	UHRF1	49	3	52	404.569
#4	FOXJ1	49	9	58	1083.22
#5	TCFL5	48	2	50	385.764
#6	SATB2	45	2	47	196.729
#7	TBX3	43	8	51	1282.989
#8	MEIS3	41	8	49	406.235
#9	E2F2	41	3	44	259.164
#10	NFKB2	38	14	52	1584.45
#11	BATF	36	14	50	1938.198
#12	POU2F2	34	11	45	1656.269
#13	ZNF219	34	9	43	1302.884
#14	ZNF90	34	8	42	645.5
#15	SP3	34	8	42	720.261
#16	NR2F2	34	8	42	654.527
#17	IKZF3	32	7	39	749.947
#18	TCF25	32	6	38	476.524
#19	ZNF213	32	12	44	1522.879
#20	TFAM	32	11	43	1202.725
#21	HCFC1	31	9	40	688.171
#22	NR1D1	31	6	37	811.272
#23	KLF3	31	16	47	1301.383
#24	HIF3A	31	10	41	2115.271
#25	GRHL3	31	11	42	1885.994
#26	NKX2-1	30	9	39	1159.24
#27	ETV6	30	8	38	423.427
#28	ESR2	30	8	38	692.556
#29	ZKSCAN1	30	5	35	1688.865
#30	HOXD8	30	5	35	705.84
#31	ZNF323	29	5	34	633.378
#32	C2orf3	29	7	36	2999.564
#33	NFYB	28	16	44	1592.656
#34	ELK1	28	20	48	2945.291
#35	ZNF93	28	8	36	1481.241
#36	TP63	27	14	41	1954.271
#37	FOXP3	27	17	44	2181.097
#38	ZNF197	27	5	32	493.457
#39	GSC	27	8	35	408.915
#40	HOXC11	27	2	29	95.667
#41	CEBPB	27	18	45	2899.425
#42	ZNF91	27	6	33	664.969
#43	RFX5	27	7	34	860.459
#44	MTF1	26	6	32	708.709
#45	CSRNP3	26	14	40	1187.31
#46	TAF1B	26	8	34	400.766
#47	ZXDC	26	10	36	1233.926
#48	SMAD6	26	7	33	883.585
#49	HNF1A	26	13	39	1215.53
#50	TSHZ1	26	20	46	1694.117
#51	E2F1	25	8	33	602.895
#52	E4F1	25	13	38	1512.095
#53	MLXIPL	25	8	33	649.232
#54	ZHX3	25	8	33	1038.39
#55	SMAD1	25	11	36	1615.772
#56	TRIM29	25	8	33	850.66
#57	ZNF434	25	12	37	3345.102
#58	ATF4	25	10	35	1134.349
#59	MSC	25	2	27	407.99
#60	IKZF1	25	9	34	805.834
#61	IRX2	24	12	36	1851.426
#62	SUPT6H	24	4	28	94.229
#63	NPAT	24	15	39	1500.745
#64	MAF	24	16	40	1992.447
#65	NFIC	24	15	39	1680.188
#66	ZEB2	24	14	38	476.841
#67	IRX1	24	15	39	1142.273
#68	ZNF446	23	12	35	905.486
#69	ETV3L	23	10	33	986.355
#70	HOXC8	23	10	33	679.818
#71	IRF2	23	5	28	407.706
#72	ZNF397	23	11	34	789.37
#73	MZF1	23	20	43	2618.587
#74	SP140	23	14	37	1634.388
#75	PPARG	23	9	32	1254.222
#76	BUD31	23	11	34	922.223
#77	GATA2	23	15	38	773.762
#78	DBP	23	9	32	495.303
#79	STAT3	23	13	36	670.719
#80	AFF4	23	8	31	821.786
#81	FOXQ1	23	15	38	937.576
#82	GCM1	23	18	41	3243.033
#83	ZNF496	22	15	37	1507.319
#84	RCOR1	22	15	37	657.344
#85	CEBPA	22	15	37	2296.26
#86	ZNF18	22	22	44	1236.526
#87	NKX6-1	22	4	26	303.25
#88	JUN	22	17	39	1783.018
#89	BLZF1	22	12	34	1110.649
#90	HOXC10	22	16	38	1039.635
#91	TBX22	22	16	38	1274.434
#92	DDIT3	22	18	40	1996.99
#93	ZBTB48	21	17	38	1400.046
#94	SOX2	21	15	36	982.056
#95	MGA	21	21	42	2049.516
#96	RELB	21	12	33	820.772
#97	HESX1	21	12	33	1043.988
#98	STAT5B	21	15	36	689.332
#99	DLX3	21	10	31	9832.203
#100	TCF7L2	21	16	37	2207.627
#101	ZNF33A	21	22	43	2478.277
#102	MECOM	21	9	30	1413.396
#103	HOXB1	21	9	30	856.754
#104	ZNF263	21	17	38	1599.984
#105	RNF4	21	2	23	75.285
#106	CREBL2	21	7	28	1150.561
#107	FOS	21	11	32	1042.725
#108	NFX1	21	16	37	1190.877
#109	SMAD3	21	23	44	3038.693
#110	GATA3	20	13	33	838.03
#111	MYOG	20	4	24	35.231
#112	RORA	20	12	32	675.484
#113	ZNF274	20	21	41	2453.643
#114	CREB3	20	12	32	1169.118
#115	GAS7	20	15	35	1549.601
#116	ZSCAN21	20	19	39	1634.959
#117	PDX1	20	12	32	824.069
#118	PROX1	20	10	30	1107.425
#119	TFEB	20	15	35	1415.601
#120	THRA	20	11	31	438.737
#121	SOX11	20	5	25	285.914
#122	TFCP2	20	12	32	1180.168
#123	MNT	20	14	34	1786.719
#124	NFE2L1	20	15	35	1374.3
#125	TFDP1	19	12	31	1309.03
#126	ZNF135	19	7	26	483.381
#127	ZGPAT	19	7	26	421.322
#128	RFX1	19	8	27	883.826
#129	GLIS3	19	18	37	1597.161
#130	SPDEF	19	14	33	1313.959
#131	HDAC1	19	14	33	1518.821
#132	E2F5	19	10	29	686.537
#133	ZBTB38	19	8	27	1906.605
#134	OTX1	19	18	37	2725.98
#135	EGR1	19	5	24	624.869
#136	PHF5A	19	9	28	928.238
#137	PRDM2	19	12	31	923.943
#138	HOXB3	18	16	34	1648.915
#139	GRHL2	18	16	34	642.602
#140	EVX1	18	16	34	1577.438
#141	TFAP4	18	10	28	288.236
#142	ZSCAN18	18	4	22	133.151
#143	NEUROD1	18	19	37	2361.892
#144	ESRRG	18	18	36	1647.096
#145	HSF5	18	10	28	483.483
#146	ARNT	18	14	32	1376.102
#147	NFKB1	17	17	34	2046.333
#148	THRB	17	17	34	1299.952
#149	UBN1	17	9	26	6574.771
#150	TP73	17	6	23	285.553
#151	ST18	17	19	36	1477.156
#152	TBR1	17	21	38	759.917
#153	NR1I3	17	12	29	350.547
#154	ELK4	17	10	27	707.485
#155	BTAF1	17	20	37	882.985
#156	SOX30	17	7	24	909.155
#157	MLLT10	17	5	22	166.429
#158	SNAI3	17	15	32	1354.586
#159	DLX6	17	20	37	1357.109
#160	STAT1	17	17	34	648.818
#161	TFAP2B	17	17	34	838.222
#162	SOX5	17	11	28	855.647
#163	PKNOX2	17	19	36	1365.264
#164	TBX21	16	13	29	1236.819
#165	SRF	16	18	34	1295.499
#166	PGR	16	14	30	1072.342
#167	FEV	16	17	33	1978.636
#168	STRN3	16	26	42	2392.478
#169	VDR	16	20	36	1750.654
#170	NOLC1	16	11	27	290.013
#171	KLF2	16	13	29	1504.852
#172	TBX15	16	7	23	365.808
#173	FOXI3	16	10	26	431.867
#174	TEF	16	25	41	1756.873
#175	ZNF37A	16	15	31	1199.14
#176	CREB3L1	16	19	35	1807.298
#177	ZNF174	16	22	38	970.392
#178	ZNF281	16	17	33	2181.243
#179	ZNF154	16	12	28	1102.205
#180	IRX3	16	16	32	1246.752
#181	SIM2	16	15	31	1096.922
#182	PBX4	15	16	31	1398.862
#183	HMGA1	15	9	24	899.444
#184	LASS5	15	12	27	465.513
#185	FBXW7	15	15	30	1849.342
#186	HOXA10	15	28	43	2346.52
#187	ZFP90	15	19	34	1184.473
#188	GBX1	15	19	34	1954.66
#189	ESRRA	15	13	28	1475.624
#190	ZNF75D	15	3	18	199.759
#191	CBL	15	9	24	693.939
#192	SCML1	15	13	28	1138.097
#193	HMBOX1	15	11	26	640.645
#194	ZFP36L1	15	18	33	871.369
#195	GTF2I	15	12	27	807.717
#196	TAF7	15	11	26	512.612
#197	ZIM2	15	16	31	1360.278
#198	SALL1	15	16	31	892.412
#199	FOXE1	15	5	20	99.287
#200	FOXA1	15	12	27	685.301
#201	SIM1	15	23	38	1632.633
#202	SLC2A4RG	15	6	21	1557.649
#203	RUNX1T1	14	26	40	2413.809
#204	MLL	14	12	26	665.18
#205	CSRNP1	14	3	17	78.809
#206	SOX13	14	8	22	680.086
#207	TWIST1	14	9	23	547.768
#208	TBP	14	13	27	1118.219
#209	SPIB	14	3	17	215.545
#210	HOXD1	14	18	32	924.424
#211	EGR4	14	18	32	1796.322
#212	HOXD4	14	22	36	1230.408
#213	IRF5	14	7	21	2265.727
#214	FOXM1	14	13	27	1149.525
#215	TSC22D4	14	14	28	1252.003
#216	MTA1	14	15	29	1015.447
#217	FOXC2	14	18	32	1013.488
#218	SOX17	14	20	34	821.617
#219	ETS2	14	7	21	418.08
#220	ZNF167	14	15	29	3032.599
#221	BRD8	14	12	26	557.092
#222	ZNF287	14	15	29	2182.88
#223	FOXP1	14	18	32	1925.966
#224	RBPJ	14	9	23	411.941
#225	AHCTF1	14	16	30	1039.861
#226	TFEC	13	9	22	529.968
#227	ELF5	13	3	16	94.372
#228	TSHZ2	13	0	13	0
#229	SMAD2	13	22	35	861.412
#230	MYC	13	14	27	536.888
#231	KLF11	13	24	37	917.773
#232	NRL	13	8	21	561.258
#233	ZSCAN29	13	22	35	1905.881
#234	ZNF45	13	20	33	1061.968
#235	HMX1	13	8	21	130.142
#236	SNAPC5	13	15	28	1099.968
#237	RHOXF2	13	12	25	455.94
#238	SIX6	13	13	26	880.138
#239	ZXDA	13	18	31	933.627
#240	FOXP2	13	20	33	736.985
#241	POU3F4	13	17	30	1533.398
#242	ZNF483	13	17	30	634.266
#243	HOXD3	13	13	26	614.86
#244	MAFG	13	16	29	522.846
#245	YY1	13	19	32	1537.627
#246	TCF12	13	12	25	581.78
#247	PURA	13	13	26	716.272
#248	IRF3	13	12	25	857.756
#249	FOXC1	13	10	23	820.773
#250	HES5	12	24	36	1476.049
#251	SMAD4	12	23	35	1686.695
#252	ADNP2	12	22	34	1362.631
#253	ESR1	12	14	26	732.015
#254	TCEAL1	12	5	17	542.822
#255	GSX1	12	5	17	279.526
#256	FOSL2	12	10	22	447.47
#257	PRRX2	12	9	21	582.461
#258	HIC1	12	14	26	747.899
#259	USF1	12	19	31	1080.428
#260	HIF1A	12	10	22	1301.234
#261	FLI1	12	12	24	589.784
#262	ESRRB	12	17	29	1079.088
#263	MBD1	12	8	20	209.243
#264	HOPX	12	20	32	1402.336
#265	WT1	12	14	26	603.653
#266	POU1F1	12	3	15	35.996
#267	TEAD4	12	16	28	681.059
#268	PPARA	12	9	21	429.56
#269	PA2G4	12	12	24	852.392
#270	TCF7L1	12	18	30	636.352
#271	CTCF	12	8	20	240.287
#272	ZNF238	12	20	32	751.929
#273	ERF	12	20	32	1010.818
#274	NR1H2	12	14	26	1057.941
#275	HOXA9	12	13	25	926.566
#276	ZSCAN16	12	22	34	918.28
#277	MSL3	12	13	25	714.485
#278	SMAD9	11	16	27	987.333
#279	TBX5	11	20	31	1793.792
#280	IRX4	11	9	20	425.661
#281	PAX8	11	7	18	260.38
#282	NR4A2	11	13	24	534.439
#283	ZSCAN5A	11	15	26	640.776
#284	MYF6	11	21	32	1357.412
#285	GTF2H4	11	14	25	925.772
#286	MIXL1	11	6	17	198.158
#287	ZNF138	11	20	31	469.599
#288	SHOX	11	18	29	1299.763
#289	DLX2	11	25	36	2764.926
#290	HES6	11	11	22	1088.347
#291	TRIM28	11	23	34	1179.963
#292	ELF4	11	25	36	1301.59
#293	C5orf41	11	18	29	744.961
#294	EN1	11	17	28	1299.305
#295	MLX	11	9	20	340.016
#296	EMX1	11	17	28	1654.306
#297	NR2F6	11	3	14	135.146
#298	HNF4A	11	13	24	2390
#299	FOSB	11	4	15	146.854
#300	ELF2	11	25	36	1276.359
#301	SCML2	11	14	25	856.887
#302	KLF4	11	3	14	82.257
#303	POU2F1	11	14	25	1010.212
#304	MEIS1	11	17	28	828.095
#305	KLF5	11	17	28	796.024
#306	GTF2IRD1	11	18	29	561.777
#307	PFDN1	11	6	17	3667.864
#308	ZIC3	11	16	27	966.349
#309	PHOX2B	11	9	20	684.342
#310	SCRT1	10	12	22	530.724
#311	SIN3A	10	16	26	487.057
#312	SOX9	10	3	13	60.373
#313	RFXANK	10	15	25	973.554
#314	LHX4	10	16	26	1108.463
#315	CTBP1	10	15	25	1077.416
#316	REXO4	10	10	20	456.918
#317	HES1	10	22	32	1550.939
#318	CREBBP	10	4	14	199.922
#319	TGIF1	10	15	25	955.376
#320	ZNF187	10	19	29	1281.849
#321	HOXC9	10	15	25	791.792
#322	PLAGL2	10	28	38	944.706
#323	GSX2	10	12	22	759.686
#324	NFIA	10	21	31	663.868
#325	MSX2	10	17	27	1372.701
#326	FOXA2	10	14	24	836.967
#327	OVOL1	10	13	23	544.688
#328	TFAP2A	10	23	33	859.437
#329	ZFHX2	10	9	19	679.337
#330	TEAD3	10	9	19	1018.522
#331	HNRNPK	10	9	19	860.605
#332	TULP4	10	19	29	1046.662
#333	TAL1	10	18	28	960.612
#334	IRF7	10	12	22	552.505
#335	SP1	10	4	14	224.819
#336	SNAI2	10	6	16	208.799
#337	ATF2	10	26	36	1750.005
#338	LASS2	10	7	17	233.368
#339	ELF1	9	20	29	1351.371
#340	POU4F3	9	22	31	999.026
#341	GABPA	9	20	29	850.072
#342	E2F3	9	11	20	401.06
#343	SCAND3	9	22	31	1670.447
#344	ZFHX4	9	13	22	773.241
#345	SOX12	9	19	28	1367.813
#346	POU5F2	9	23	32	969.126
#347	UBP1	9	24	33	919.139
#348	BCL11B	9	12	21	333.51
#349	GABPB1	9	17	26	727.047
#350	ZIC5	9	24	33	662.655
#351	CSRNP2	9	24	33	761.947
#352	AEBP1	9	24	33	948.116
#353	RUNX1	9	17	26	365.398
#354	GCFC1	9	26	35	1225.801
#355	KCNH8	9	18	27	1112.787
#356	MAFB	9	16	25	439.321
#357	SOX6	9	19	28	711.43
#358	HINFP	9	17	26	338.309
#359	PBX2	9	18	27	758.943
#360	KLF10	9	21	30	1278.952
#361	FOSL1	9	17	26	664.775
#362	SCAND2	9	24	33	891.364
#363	SATB1	9	15	24	580.353
#364	NEUROG1	9	13	22	441.784
#365	RXRA	9	5	14	109.144
#366	TRIM25	9	10	19	432.985
#367	ZSCAN2	9	13	22	1122.701
#368	CNOT8	9	20	29	868.292
#369	HSF4	9	17	26	576.072
#370	JUNB	9	19	28	506.197
#371	DMTF1	8	18	26	1000.04
#372	EGR3	8	13	21	449.698
#373	CREB3L3	8	6	14	255.123
#374	CDKN2A	8	17	25	452.594
#375	ZNF215	8	17	25	484.394
#376	PAX5	8	13	21	516.842
#377	ZNF192	8	15	23	672.314
#378	TLX2	8	19	27	555.649
#379	HOXB2	8	15	23	726.644
#380	ZC3H8	8	3	11	71.67
#381	CTNNB1	8	4	12	46.389
#382	CNBP	8	13	21	804.375
#383	CREM	8	20	28	618.429
#384	PURB	8	23	31	944.438
#385	NCOR1	8	3	11	150.602
#386	ETV5	8	14	22	809.594
#387	XBP1	8	12	20	763.634
#388	TRPS1	8	16	24	918.271
#389	SOX10	8	14	22	387.683
#390	ZRANB2	8	19	27	842.45
#391	POU3F1	8	10	18	565.431
#392	RERE	8	23	31	484.76
#393	RORB	8	14	22	538.73
#394	NFIB	8	6	14	176.705
#395	HMX2	8	20	28	393.995
#396	TADA2A	8	5	13	166.939
#397	NR3C1	7	22	29	583.007
#398	HIRA	7	13	20	197.874
#399	ZKSCAN3	7	20	27	498.16
#400	NFE2	7	17	24	1102.59
#401	RB1	7	24	31	1014.738
#402	SOX18	7	9	16	226.078
#403	ARID4A	7	7	14	241.485
#404	MEF2A	7	10	17	2137.843
#405	ERG	7	23	30	696.837
#406	ARNTL	7	6	13	97.196
#407	MESP1	7	23	30	553.447
#408	NR2F1	7	16	23	794.773
#409	MEIS3P1	7	11	18	330.784
#410	SPEN	7	13	20	377.505
#411	SOLH	7	19	26	271.804
#412	TCF19	7	13	20	443.158
#413	IKZF4	7	17	24	625.828
#414	L3MBTL4	7	15	22	616.217
#415	TAF5L	7	20	27	605.008
#416	RUNX3	7	21	28	809.553
#417	ETV3	7	6	13	282.34
#418	WNT5A	7	13	20	476.601
#419	TARDBP	7	22	29	822.999
#420	TCF7	7	8	15	183.211
#421	KLF12	7	26	33	621.601
#422	ZNF236	7	14	21	1411.22
#423	CEBPE	7	16	23	583.96
#424	USF2	6	19	25	440.205
#425	CREB3L2	6	32	38	1496.241
#426	HOXA1	6	17	23	390.001
#427	BATF2	6	19	25	776.475
#428	NPAS2	6	3	9	36.564
#429	MYCN	6	13	19	301.765
#430	TMEM229A	6	16	22	832.125
#431	SOX7	6	4	10	36.567
#432	MITF	6	25	31	508.52
#433	HNF4G	6	5	11	138.46
#434	GLI2	6	20	26	1218.356
#435	TP53	6	22	28	661.341
#436	GATAD1	6	14	20	402.351
#437	CSDA	6	12	18	388.22
#438	ZIC1	6	24	30	1183.475
#439	AR	6	7	13	120.152
#440	ZNF217	6	18	24	299.23
#441	FOXN2	6	23	29	481.121
#442	NKX2-3	6	21	27	491.048
#443	TRERF1	6	20	26	521.178
#444	ZBTB25	5	17	22	381.081
#445	CREBZF	5	20	25	366.089
#446	PAX7	5	17	22	391.635
#447	ELK3	5	17	22	440.012
#448	PLAG1	5	20	25	448.098
#449	PBX1	5	20	25	548.18
#450	ZNF193	5	27	32	805.745
#451	NANOGP1	5	26	31	821.091
#452	LHX3	5	15	20	419.583
#453	ZNF207	5	22	27	962.278
#454	ZNF445	5	8	13	36.703
#455	MAFK	5	24	29	453.224
#456	TFDP2	5	18	23	1139.869
#457	VAX2	5	16	21	264.587
#458	NFIX	5	26	31	443.818
#459	MSX1	5	25	30	998.497
#460	HNF1B	5	23	28	311.829
#461	POU2F3	4	15	19	402.561
#462	MYT1L	4	18	22	234.719
#463	LHX9	4	26	30	1170.543
#464	NKX1-2	4	23	27	274.813
#465	HMGA2	4	23	27	740.727
#466	FOXD4	4	11	15	445.6
#467	KLF15	4	19	23	458.205
#468	SOX4	4	18	22	220.247
#469	GATAD2A	4	25	29	299.416
#470	AFF1	4	17	21	397.197
#471	CUX2	4	21	25	453.033
#472	TSC22D2	3	11	14	251.537
#473	ZNF639	3	23	26	2700.804
#474	FOXO4	3	26	29	313.879
#475	ZNF24	3	20	23	395.536
#476	HOXB7	3	8	11	350.526
#477	LZTR1	3	21	24	618.706
#478	SIX3	3	16	19	204.527
#479	FOXJ3	3	21	24	487.554
#480	FOXK2	3	26	29	265.46
#481	FOXH1	3	14	17	185.983
#482	BARHL2	3	31	34	421.711
#483	HOXA4	3	13	16	154.393
#484	TAF13	3	23	26	991.237
#485	MTA3	3	23	26	274.14
#486	STAT4	3	20	23	316.757
#487	NFYC	2	12	14	126.62
#488	RELA	2	21	23	141.681
#489	NR4A1	2	12	14	201.61
#490	HMGB1	2	24	26	134.269
#491	ZNF19	2	22	24	224.067
#492	MEIS2	2	18	20	115.732
#493	FOXP4	2	23	25	253.376
#494	ARNTL2	2	17	19	60.92
#495	NOTCH1	2	30	32	661.223
#496	ARX	2	23	25	203.099
#497	TCF4	2	22	24	374.298
#498	FOXD1	2	22	24	333.223
#499	ZNF85	2	17	19	3636.565
#500	SUPT4H1	1	23	24	39.312