Hub Rank	Node	Children	Parents	Degree	Betweenness
#1	IKZF1	35	2	37	101.72
#2	ADNP	33	6	39	304.271
#3	GTF2H3	33	5	38	686.9
#4	EBF1	33	6	39	1094.373
#5	TCF12	33	2	35	177.427
#6	FBXW7	33	7	40	11397.002
#7	SPEN	33	7	40	384.046
#8	SOX6	32	3	35	2730.376
#9	NR3C1	31	6	37	1282.723
#10	TAF10	31	9	40	3601.824
#11	CEBPB	31	6	37	863.311
#12	HNRNPAB	30	4	34	1176.021
#13	HMGA1	30	5	35	1957.221
#14	ETS1	30	6	36	1088.333
#15	ZRANB2	30	3	33	198.082
#16	CNOT7	30	2	32	661.048
#17	MEF2A	28	7	35	1301.332
#18	BTAF1	28	6	34	659.047
#19	ZNF131	28	4	32	1699.086
#20	FOXJ3	28	3	31	2057.994
#21	NR1H3	28	1	29	510.749
#22	MAFB	27	1	28	13.564
#23	HMGB1	27	9	36	1872.794
#24	FOXO3	27	13	40	3493.368
#25	HIF1A	25	5	30	1407.995
#26	ATF3	24	7	31	5295.018
#27	DMTF1	24	5	29	1600.869
#28	E2F6	24	4	28	201.808
#29	YY1	24	7	31	3746.566
#30	CEBPD	23	4	27	1210.412
#31	PTTG1	23	1	24	1561.537
#32	ZEB1	22	5	27	4058.194
#33	POU2F1	22	7	29	5445.651
#34	ZNF277	21	8	29	3998.691
#35	TRIM22	21	10	31	1772.629
#36	ZNF24	21	6	27	1569.699
#37	RB1	21	7	28	2494.513
#38	BATF3	21	9	30	1881.659
#39	ZNF83	20	8	28	524.967
#40	MYNN	20	8	28	1166.358
#41	MAFF	20	10	30	1036.365
#42	FOXO1	20	8	28	858.633
#43	MGA	20	8	28	5712.882
#44	NEUROD1	20	5	25	86.29
#45	EDF1	20	8	28	3000.777
#46	GATA3	20	8	28	825.635
#47	STAT1	19	8	27	793.05
#48	MEF2C	19	11	30	1209.932
#49	FOXP1	19	18	37	8384.806
#50	SP3	19	6	25	1259.905
#51	FUBP1	19	7	26	3484.265
#52	STAT5A	18	10	28	15932.476
#53	SCAND1	18	9	27	701.954
#54	BTG2	18	10	28	3835.457
#55	SPDEF	18	6	24	508.949
#56	ETV5	18	5	23	297.262
#57	GCFC1	18	5	23	1932.924
#58	KLF2	18	4	22	5306.505
#59	AFF4	18	12	30	7031.356
#60	ZNF33B	17	4	21	765.828
#61	BATF	17	9	26	1220.699
#62	NFAT5	17	7	24	219.9
#63	MBD1	17	8	25	1668.912
#64	NFE2L2	17	13	30	3627.019
#65	NFATC1	17	5	22	1118.77
#66	CREB1	17	5	22	2389.638
#67	RERE	17	6	23	1257.858
#68	POU2F2	17	4	21	496.542
#69	MYBL2	17	7	24	2069.913
#70	HDAC1	17	9	26	2203.345
#71	KLF12	16	8	24	6024.874
#72	CBL	16	9	25	600.835
#73	SNAPC5	16	14	30	6522.008
#74	MAF	16	8	24	2193.77
#75	BCL3	16	5	21	1878.715
#76	E2F8	16	7	23	4456.897
#77	EPAS1	15	4	19	956.84
#78	FLI1	15	7	22	1334.236
#79	MSRB2	15	13	28	1951.065
#80	TRIM28	15	7	22	2009.069
#81	NFE2L1	15	6	21	6315.798
#82	SOX15	15	2	17	773.077
#83	ZHX2	15	7	22	857.601
#84	ZNF281	15	14	29	8902.293
#85	KLF10	15	7	22	8719.161
#86	NR2F6	14	8	22	996.27
#87	IRX2	14	9	23	2860.579
#88	YBX1	14	11	25	1887.302
#89	PRDM1	14	4	18	872.181
#90	BHLHE40	14	8	22	6516.239
#91	CREBBP	14	11	25	7293.193
#92	CBFB	14	10	24	1062.335
#93	UBP1	14	8	22	509.37
#94	LCOR	14	7	21	690.003
#95	BACH2	14	10	24	318.571
#96	NR2C2	14	12	26	480.535
#97	RELA	14	6	20	503.043
#98	HOXD8	14	5	19	177.801
#99	AEBP1	13	7	20	2917.96
#100	BCL6	13	9	22	1681.728
#101	JUND	13	6	19	2333.534
#102	HMG20A	13	8	21	3075.337
#103	PLSCR1	13	8	21	3269.796
#104	ZFP90	13	8	21	692.563
#105	UHRF1	13	3	16	747.224
#106	BHLHE41	13	8	21	3118.814
#107	TAF7	13	9	22	4069.923
#108	MTA1	13	11	24	2045.268
#109	FOXP2	13	7	20	851.536
#110	CREB3L2	13	4	17	345.719
#111	ZSCAN20	13	11	24	949.138
#112	PKNOX1	13	3	16	2749.93
#113	EVX1	13	8	21	3964.671
#114	C5orf41	13	7	20	3295.895
#115	NANOG	13	6	19	55.036
#116	ZNF189	13	10	23	2485.313
#117	MITF	12	7	19	350.536
#118	IRF8	12	5	17	452.273
#119	HMGB2	12	4	16	737.664
#120	ELK3	12	8	20	1590.138
#121	NFIB	12	12	24	1482.431
#122	STAT3	12	13	25	17856.266
#123	ATF2	12	8	20	1098.602
#124	CBFA2T2	12	13	25	6207.397
#125	SMAD2	12	11	23	1373.877
#126	ATF1	12	11	23	3179.598
#127	MEIS3P1	12	8	20	519.47
#128	E2F5	12	9	21	3621.061
#129	CTCF	12	9	21	4222.651
#130	PROX1	12	6	18	6757.772
#131	ZNF219	12	8	20	1499.728
#132	E2F1	12	7	19	1136.031
#133	HSF4	12	7	19	1156.329
#134	TBX6	11	7	18	805.418
#135	ASCL2	11	3	14	67.691
#136	NFIC	11	5	16	7994.538
#137	PRDM2	11	8	19	2371.332
#138	ZFPM1	11	6	17	953.489
#139	NFATC2	11	9	20	3452.904
#140	PRRX1	11	6	17	1113.896
#141	TSC22D3	11	11	22	1572.263
#142	BUD31	11	16	27	2055.688
#143	TFEC	11	6	17	3493.144
#144	XBP1	11	6	17	1473.63
#145	ECSIT	11	13	24	9489.248
#146	SP140	11	7	18	1740.109
#147	CREBL2	11	14	25	3332.962
#148	MLX	11	9	20	1132.528
#149	TFDP1	11	13	24	10972.678
#150	TCF4	11	8	19	3024.737
#151	ZNF45	10	9	19	356.813
#152	CUX1	10	11	21	5582.87
#153	RFXANK	10	9	19	2355.526
#154	RNF4	10	10	20	2220.643
#155	E2F2	10	6	16	2235.796
#156	LMO4	10	15	25	15602.814
#157	SIM2	10	8	18	615.745
#158	C1orf85	10	11	21	2166.517
#159	GLIS2	10	5	15	171.566
#160	TCF7	10	9	19	1876.085
#161	MLL	10	15	25	3340.947
#162	HNRNPK	10	7	17	397.261
#163	TSHZ2	10	9	19	500.344
#164	FOXM1	10	5	15	510.104
#165	SMAD5	10	7	17	824.796
#166	PBX3	10	8	18	635.771
#167	ESRRA	10	13	23	957.087
#168	ZKSCAN5	10	9	19	6868.779
#169	SIN3A	10	9	19	1681.386
#170	CREB3	10	8	18	1515.199
#171	IRF1	10	7	17	992.812
#172	DDIT3	10	10	20	880.423
#173	RCOR1	9	7	16	509.173
#174	HINFP	9	6	15	1225.668
#175	NR2F2	9	9	18	3402.563
#176	SPIB	9	10	19	2590.818
#177	SLC30A9	9	11	20	3094.863
#178	ARNTL2	9	12	21	2790.125
#179	TSC22D2	9	12	21	1400.215
#180	TGIF1	9	9	18	1483.799
#181	PA2G4	9	11	20	2950.113
#182	TAF4	9	6	15	248.344
#183	ZNF367	9	7	16	2377.59
#184	REL	9	10	19	522.262
#185	MSX1	9	11	20	1278.796
#186	GAS7	9	9	18	3152.104
#187	AHR	9	13	22	2917.166
#188	ZBTB38	9	10	19	3205.721
#189	JUNB	9	8	17	687.557
#190	ZNF434	9	9	18	4306.987
#191	ZNF500	9	7	16	1690.583
#192	ARNTL	9	11	20	3233.935
#193	ZNF37A	8	10	18	5863.558
#194	TCF25	8	9	17	1528.237
#195	ZKSCAN1	8	11	19	4639.51
#196	CBFA2T3	8	10	18	510.546
#197	ZNF444	8	10	18	1483.994
#198	MEIS1	8	4	12	87.489
#199	FOXN3	8	7	15	613.361
#200	ENO1	8	7	15	1355.643
#201	ZEB2	8	11	19	829.848
#202	NFX1	8	13	21	4246.52
#203	TCEAL1	8	5	13	1299.492
#204	ZNF207	8	13	21	1651.348
#205	ZNF628	8	6	14	838.157
#206	CTBP1	8	12	20	2055.25
#207	HSF1	8	10	18	3273.296
#208	ZNF133	8	9	17	2571.103
#209	KLF3	8	8	16	370.093
#210	SATB2	8	8	16	110.452
#211	ELF2	8	7	15	1899.29
#212	HMG20B	8	9	17	1848.677
#213	TFE3	8	8	16	4467.338
#214	NKX2-8	8	5	13	795.798
#215	SREBF2	8	8	16	379.815
#216	ZXDC	8	4	12	1093.982
#217	ZNF140	8	13	21	2263.616
#218	TAF1B	8	10	18	4481.672
#219	ZGPAT	8	10	18	1905.47
#220	PHF5A	7	11	18	4579.08
#221	CREB3L1	7	12	19	5260.556
#222	ZSCAN21	7	9	16	3936.156
#223	RUNX2	7	13	20	4238.64
#224	TP53	7	5	12	1415.998
#225	FOXN2	7	10	17	1703.066
#226	TFAM	7	13	20	1785.891
#227	UBN1	7	7	14	865.172
#228	SUPT4H1	7	11	18	1911.528
#229	HHEX	7	4	11	205.017
#230	HMBOX1	7	11	18	843.69
#231	JDP2	7	9	16	1032.291
#232	ZSCAN18	7	13	20	6902.313
#233	ZNF268	7	7	14	534.179
#234	BACH1	7	8	15	3663.574
#235	STAT4	7	9	16	140.236
#236	ZNF117	7	10	17	2896.76
#237	PBX1	7	6	13	285.178
#238	ATF7	7	8	15	1328.368
#239	TCF3	7	9	16	3027.458
#240	STAT2	7	11	18	2352.936
#241	PHF1	7	12	19	3657.687
#242	NCOR1	7	9	16	738.039
#243	HMX1	7	4	11	179.752
#244	RORA	7	8	15	1812.791
#245	PBX4	7	7	14	1415.638
#246	NFIL3	7	9	16	2459.209
#247	NPAT	7	13	20	574.182
#248	EGR2	7	14	21	1553.685
#249	ZNF639	7	11	18	578.116
#250	AFF1	7	14	21	1588.938
#251	ZNF85	7	11	18	994.892
#252	GATAD1	6	6	12	543.218
#253	ARID4A	6	10	16	680.974
#254	LASS2	6	7	13	193.75
#255	STRN3	6	5	11	118.608
#256	CITED2	6	11	17	237.864
#257	FOS	6	8	14	550.578
#258	HOXA9	6	8	14	2312.057
#259	FOXG1	6	8	14	1698.426
#260	ZNF274	6	11	17	3782.944
#261	NKX2-5	6	5	11	5201.362
#262	HOXA2	6	11	17	3790.769
#263	PURA	6	9	15	1366.813
#264	CREBZF	6	9	15	4774.178
#265	NFYA	6	9	15	2522.604
#266	ETV6	6	10	16	1948.126
#267	PCGF2	6	8	14	1017.705
#268	KLF6	6	12	18	3175.109
#269	EOMES	6	11	17	2615.834
#270	HOXA1	6	10	16	2103.633
#271	JUN	6	12	18	2986.515
#272	CNBP	6	10	16	2312.485
#273	HOXA5	6	16	22	5201.845
#274	ZFP36L1	6	11	17	436.185
#275	KLF9	6	10	16	1088.51
#276	E2F3	6	9	15	1349.963
#277	ISX	6	6	12	4582.388
#278	TAF5	6	9	15	732.207
#279	FOSB	6	5	11	401.905
#280	ZNF496	6	13	19	4656.882
#281	CTNNB1	6	8	14	250.244
#282	E2F7	6	9	15	2056.92
#283	PURB	6	10	16	1517.722
#284	TCF7L2	6	20	26	1528.896
#285	SREBF1	6	12	18	733.298
#286	ZNF75D	6	8	14	1459.19
#287	MYC	6	13	19	5159.102
#288	ZNF91	6	10	16	186.362
#289	FOXC1	6	16	22	1644.752
#290	MZF1	6	11	17	998.49
#291	MESP1	6	6	12	153.803
#292	TRERF1	5	9	14	1020.409
#293	ELF4	5	10	15	1115.972
#294	RBCK1	5	9	14	60.846
#295	RBPJ	5	11	16	3878.007
#296	KLF4	5	7	12	368.575
#297	TSC22D1	5	13	18	882.268
#298	LASS6	5	11	16	1840.533
#299	TARDBP	5	10	15	7046.879
#300	CREM	5	14	19	1745.554
#301	ZNF232	5	8	13	705.631
#302	SMAD4	5	7	12	159.927
#303	ZBTB48	5	12	17	7924.718
#304	PPARA	5	11	16	1261.515
#305	POU6F1	5	4	9	1123.12
#306	KDM5A	5	10	15	245.954
#307	TCF19	5	7	12	912.743
#308	GABPA	5	10	15	1195.684
#309	TSHZ1	5	16	21	2441.396
#310	MEF2D	5	11	16	487.222
#311	ZKSCAN4	5	16	21	3042.973
#312	ISL2	5	6	11	1232.41
#313	YEATS4	5	9	14	965.857
#314	VAV1	5	9	14	2118.405
#315	SLC26A3	5	8	13	124.215
#316	CSDA	5	17	22	8980.553
#317	SMAD3	5	10	15	376.302
#318	AATF	5	10	15	914.396
#319	FOXC2	5	9	14	539.546
#320	RUNX1	5	10	15	2785.587
#321	RFXAP	5	9	14	2816.862
#322	AHCTF1	5	9	14	805.633
#323	SLC2A4RG	5	9	14	451.583
#324	ZNF18	5	10	15	1728.548
#325	PLAG1	5	6	11	649.922
#326	HOXB7	5	9	14	904.854
#327	HOXA7	5	9	14	1741.919
#328	FOSL2	5	12	17	2547.356
#329	ELK1	5	12	17	1205.444
#330	GABPB1	5	11	16	1251.684
#331	MAFG	5	9	14	1909.2
#332	CCRN4L	5	8	13	360.379
#333	PFDN1	5	11	16	985.425
#334	SOLH	5	9	14	693.2
#335	SCML1	4	8	12	698.29
#336	LZTR1	4	10	14	692.577
#337	SOX9	4	11	15	1745.726
#338	MTF1	4	11	15	220.529
#339	TFDP2	4	13	17	2655.698
#340	ZNF92	4	9	13	251.184
#341	LZTS1	4	9	13	269.804
#342	NFYC	4	4	8	1232.088
#343	TAF4B	4	8	12	446.315
#344	SATB1	4	13	17	6087.14
#345	MYOG	4	4	8	204.059
#346	SOX13	4	9	13	1515.691
#347	C11orf9	4	8	12	934.858
#348	STAT6	4	9	13	1342.868
#349	TCFL5	4	8	12	928.78
#350	ZNF167	4	8	12	175.329
#351	HES6	4	8	12	864.321
#352	MEIS2	4	9	13	630.503
#353	ZHX1	4	10	14	597.811
#354	CEBPA	4	4	8	51.296
#355	ZNF70	4	6	10	151.129
#356	NR1H2	4	8	12	1621.622
#357	FOXO6	4	9	13	3770.352
#358	ZSCAN16	4	11	15	806.117
#359	ETV7	4	10	14	286.68
#360	KLF7	4	12	16	2599.963
#361	NFXL1	4	9	13	1730.796
#362	ATF5	4	13	17	1404.858
#363	HDAC2	4	11	15	2401.983
#364	ZBTB25	4	6	10	142.017
#365	DMRT2	4	7	11	1632.715
#366	ONECUT2	4	6	10	2213.545
#367	CNOT8	4	5	9	80.046
#368	ZNF80	4	8	12	277.519
#369	VDR	4	10	14	1511.599
#370	ARNT	4	10	14	1338.27
#371	SOX8	4	8	12	1033.61
#372	HOXA10	4	14	18	877.966
#373	SP4	4	12	16	640.115
#374	PPARD	4	10	14	5560.439
#375	SOX4	4	8	12	533.574
#376	ZNF256	4	10	14	1975.573
#377	SP1	4	8	12	164.393
#378	C2orf3	4	7	11	2269.313
#379	NR2C1	4	11	15	2175.467
#380	TBX5	4	6	10	2157.876
#381	KLF16	4	6	10	198.668
#382	ZNF217	4	10	14	2146.048
#383	NFATC4	4	9	13	7266.695
#384	EGR4	3	11	14	1606.638
#385	MNT	3	6	9	1192.982
#386	MLLT10	3	8	11	344.803
#387	SCML2	3	8	11	999.237
#388	MXD1	3	10	13	477.738
#389	IRF2	3	10	13	1161.262
#390	POU2F3	3	7	10	1575.296
#391	SPIC	3	10	13	2170.029
#392	ZNF174	3	9	12	769.874
#393	MAFK	3	11	14	5910.585
#394	ELF1	3	12	15	2652.956
#395	NFATC3	3	8	11	356.141
#396	ZNF236	3	6	9	764.968
#397	ZNF93	3	9	12	2091.066
#398	RCAN1	3	11	14	656.119
#399	PLAGL2	3	8	11	606.421
#400	HCLS1	3	12	15	1180.114
#401	FOXD1	3	10	13	3475.478
#402	ZNF238	3	12	15	457.676
#403	NFYB	3	6	9	710.392
#404	CLOCK	3	7	10	759.837
#405	ZNF81	3	8	11	451.894
#406	THRB	3	12	15	314.058
#407	EHF	3	12	15	282.169
#408	DLX4	3	13	16	432.412
#409	TADA3	3	9	12	479.251
#410	HEY1	3	9	12	707.288
#411	RUNX3	3	11	14	629.128
#412	ESR1	3	8	11	670.947
#413	ZNF138	3	7	10	86.026
#414	KLF11	3	7	10	492.819
#415	ADNP2	3	10	13	2060.802
#416	SIX5	3	9	12	1403.361
#417	ASCL1	3	12	15	1365.6
#418	HNF1B	3	6	9	1075.86
#419	ZC3H8	3	8	11	2372.261
#420	ZNF394	3	12	15	906.988
#421	TFEB	3	13	16	1063.377
#422	SHOX	3	11	14	614.508
#423	TGIF2	3	7	10	1290.886
#424	TP63	3	11	14	313.528
#425	BCL11B	3	5	8	767.966
#426	IRF9	3	11	14	419.319
#427	ATF4	2	10	12	716.378
#428	GATAD2A	2	10	12	196.391
#429	NOLC1	2	7	9	677.913
#430	HNF4A	2	2	4	23.453
#431	SIX3	2	11	13	1133.847
#432	KDM5B	2	18	20	8882.312
#433	IRX3	2	7	9	491.542
#434	CDKN2A	2	8	10	945.3
#435	LASS5	2	10	12	1132.318
#436	ZNF215	2	10	12	1448.236
#437	ZNF397	2	11	13	330.036
#438	SMAD1	2	9	11	776.074
#439	MEOX1	2	5	7	29.453
#440	WNT5A	2	10	12	1325.722
#441	TWIST1	2	15	17	2315.423
#442	TLX2	2	9	11	275.579
#443	KCNH8	2	11	13	738.498
#444	DLX1	2	10	12	635.281
#445	MECOM	2	8	10	575.044
#446	ZNF148	2	6	8	1207.185
#447	FOXK2	2	6	8	56.719
#448	ZNF165	2	14	16	5329.955
#449	NR1D2	2	7	9	208.238
#450	EGR1	2	12	14	393.94
#451	ZNF3	2	9	11	132.264
#452	SOX11	2	5	7	106.78
#453	SIX1	2	7	9	179.341
#454	MNX1	2	7	9	162.824
#455	HOXB4	2	9	11	117.329
#456	ETS2	2	9	11	65.185
#457	CSRNP2	2	9	11	422.414
#458	CSRNP1	2	7	9	193.833
#459	ZBTB17	2	11	13	1135.814
#460	SNAPC4	1	12	13	94.658
#461	NKX2-3	1	8	9	433.622
#462	SMAD9	1	7	8	498.011
#463	NFE2L3	1	10	11	267.71
#464	HEY2	1	8	9	35.148
#465	TRPS1	1	9	10	96.678
#466	TRIM25	1	7	8	109.037
#467	KLF15	1	11	12	655.68
#468	STAT5B	1	11	12	40.205
#469	E4F1	1	8	9	238.825
#470	NR1I2	1	8	9	529.037
#471	MTA3	1	7	8	1153.097
#472	ZNF33A	1	9	10	31.776
#473	HES1	1	6	7	946.877
#474	TULP4	1	9	10	117.803
#475	RFX5	1	16	17	210.553
#476	IRF4	1	7	8	42.807
#477	LHX2	1	8	9	925.785
#478	ZSCAN29	1	11	12	186.512
#479	SALL2	1	5	6	120.152
#480	ESR2	1	7	8	413.8
#481	IRF5	1	8	9	869.795
#482	HOXA13	1	8	9	1634.563
#483	EGR3	1	13	14	2657.087
#484	ZNF202	1	14	15	1042.977
#485	ZFP36L2	1	9	10	26.466
#486	LEF1	1	14	15	1622.047
#487	TBX19	0	5	5	0
#488	ZNF498	0	4	4	0
#489	HOXB3	0	10	10	0
#490	HOXB2	0	8	8	0
#491	RXRA	0	10	10	0
#492	HOPX	0	15	15	0
#493	MAX	0	11	11	0
#494	NR3C2	0	9	9	0
#495	WT1	0	10	10	0
#496	GTF2IRD1	0	8	8	0
#497	BRD8	0	12	12	0
#498	PITX1	0	7	7	0
#499	PHTF1	0	13	13	0
#500	IRF7	0	12	12	0