Hub Rank	Node	Children	Parents	Degree	Betweenness
#1	PLAGL2	45	4	49	249.738
#2	ZFP90	43	6	49	916.906
#3	ELF1	39	3	42	2095.06
#4	VDR	38	11	49	8426.015
#5	STAT2	38	9	47	403.165
#6	SOX8	38	7	45	581.699
#7	HAND1	37	4	41	110.855
#8	FOXD1	36	3	39	102.756
#9	CREBBP	35	4	39	3933.605
#10	CEBPB	34	2	36	121.968
#11	ESR2	34	9	43	575.305
#12	NR1H2	34	3	37	61.307
#13	ZNF75D	33	7	40	460.059
#14	SOX17	32	7	39	309.071
#15	TBX3	31	9	40	1200.507
#16	GATA4	31	10	41	281.85
#17	ZNF117	31	3	34	93.754
#18	IRX6	30	5	35	5101.609
#19	ZNF498	29	6	35	3807.025
#20	RCAN1	28	4	32	153.179
#21	VAX2	28	8	36	3689.176
#22	AFF4	28	8	36	1926.741
#23	MLXIPL	26	7	33	660.365
#24	NFKB1	26	9	35	533.254
#25	C2orf3	25	6	31	6121.506
#26	MYCN	25	6	31	665.569
#27	OTX1	25	8	33	1198.111
#28	MAFB	24	4	28	73.178
#29	IRF6	24	10	34	939.286
#30	DLX1	24	11	35	4239.781
#31	GLIS3	23	7	30	266.386
#32	BATF	23	10	33	8999.952
#33	ZFP36L1	23	4	27	700.825
#34	GCFC1	22	7	29	1292.637
#35	MAF	22	4	26	235.637
#36	SCRT1	22	6	28	7587.97
#37	HIF3A	22	6	28	570.7
#38	HOXA10	22	5	27	3615.307
#39	PDX1	21	8	29	8574.162
#40	KLF6	21	11	32	1555.109
#41	FOXC1	21	6	27	2720.468
#42	HOXA11	21	10	31	6595.655
#43	RBCK1	20	10	30	884.455
#44	ZNF215	20	10	30	1698.284
#45	ZNF24	20	8	28	1370.833
#46	HMGA1	20	8	28	3496.062
#47	MYCL1	20	5	25	280.298
#48	CREB1	19	15	34	2901.973
#49	TSC22D4	19	10	29	7516.907
#50	NR2F1	19	9	28	2892.726
#51	DMTF1	19	10	29	762.456
#52	TRIM28	19	11	30	4776.282
#53	SIN3A	19	14	33	711.671
#54	ESRRG	19	6	25	751.225
#55	FOXE1	19	9	28	104.122
#56	NR5A2	19	16	35	9156.451
#57	SCAND2	18	7	25	2469.357
#58	HCFC1	18	11	29	3153.902
#59	ZNF93	18	11	29	1077.783
#60	SMAD4	18	0	18	0
#61	GTF2IRD1	18	4	22	2284.115
#62	TEF	18	4	22	246.851
#63	PURB	18	4	22	454.405
#64	THRB	17	8	25	616.899
#65	NR1H4	17	11	28	1041.599
#66	GABPA	17	12	29	1085.473
#67	CREM	17	9	26	1729.099
#68	ZNF263	17	5	22	103.826
#69	HOXC12	17	1	18	9.759
#70	E2F1	17	12	29	6021.771
#71	NFKB2	17	7	24	1267.022
#72	NFIA	17	13	30	1505.625
#73	AEBP1	17	11	28	2877.969
#74	ONECUT2	17	8	25	3921.712
#75	PLSCR1	16	7	23	1081.437
#76	HMGB2	16	12	28	685.666
#77	TFAP4	16	9	25	5551.982
#78	CITED2	16	13	29	1845.649
#79	EN1	16	14	30	15465.79
#80	IKZF1	16	13	29	1265.988
#81	STRN3	16	6	22	525.789
#82	TAF10	16	10	26	834.622
#83	ZEB1	16	12	28	2556.525
#84	IRF5	16	10	26	3326.339
#85	PTH	16	7	23	477.704
#86	SHOX	16	8	24	548.157
#87	PKNOX1	16	9	25	1592.675
#88	HSF5	16	10	26	443.025
#89	ZEB2	16	10	26	702.231
#90	RARG	16	11	27	8673.4
#91	PGBD1	16	7	23	357.713
#92	NFAT5	16	10	26	4499.886
#93	MYC	16	12	28	454.21
#94	TP53	16	11	27	2012.923
#95	SMAD1	16	14	30	5113.195
#96	TBX21	15	11	26	2496.933
#97	LHX9	15	12	27	1478.928
#98	NFE2	15	4	19	145.611
#99	NFIC	15	10	25	7101.841
#100	ATF1	15	4	19	180.621
#101	HNF4A	15	10	25	122.791
#102	FOXA2	15	5	20	2383.39
#103	RB1	15	8	23	498.343
#104	ATF7	15	2	17	16.311
#105	SP3	15	8	23	361.979
#106	ARID3A	15	6	21	2307.088
#107	PRRX1	15	8	23	1942.127
#108	PPARA	15	9	24	1742.976
#109	HMGB1	15	6	21	6417.261
#110	MNT	15	7	22	431.969
#111	TGIF1	15	5	20	383.598
#112	PITX1	14	5	19	1256.692
#113	FOXJ1	14	11	25	1577.64
#114	TBX4	14	7	21	1644.876
#115	GATAD2A	14	8	22	1095.812
#116	CCRN4L	14	12	26	6906.968
#117	HNF1B	14	11	25	666.463
#118	EPAS1	14	5	19	985.554
#119	RXRA	14	9	23	204.434
#120	MAFK	14	12	26	7335.626
#121	HESX1	14	10	24	905.628
#122	NFE2L1	14	8	22	2355.063
#123	TFAP2D	14	5	19	1401.293
#124	CUX1	14	8	22	336.8
#125	ZRANB2	14	7	21	7848.792
#126	SMAD2	13	12	25	1417.159
#127	GTF2H3	13	13	26	852.082
#128	IRX1	13	13	26	1698.506
#129	FOXA1	13	5	18	594.082
#130	TRIM29	13	7	20	2882.986
#131	EGR4	13	11	24	1142.114
#132	TAF5L	13	10	23	318.069
#133	TFAP2B	13	8	21	995.44
#134	POU2F3	13	8	21	4468.288
#135	HOPX	13	10	23	1571.114
#136	ATF3	13	12	25	1866.557
#137	UHRF1	13	12	25	7100.698
#138	RBPJ	13	5	18	422.693
#139	CDKN2A	12	11	23	2137.462
#140	NR1D2	12	9	21	2908.4
#141	TRERF1	12	13	25	914.056
#142	STAT4	12	14	26	3973.122
#143	RFXANK	12	12	24	4030.195
#144	FOXJ2	12	9	21	878.061
#145	STAT1	12	12	24	2073.448
#146	LASS2	12	9	21	1346.006
#147	TBX5	12	9	21	1831.501
#148	USF1	12	9	21	1365.738
#149	MEF2D	12	11	23	1311.633
#150	IRF8	12	13	25	1576.913
#151	ZXDA	12	11	23	2893.2
#152	FUBP1	12	5	17	297.208
#153	TMEM229A	12	13	25	1603.806
#154	HIF1A	12	7	19	1973.987
#155	HMX2	12	8	20	1555.396
#156	FOXO3	12	11	23	289.954
#157	RORA	11	11	22	914.031
#158	CTNNB1	11	14	25	1433.516
#159	MAX	11	5	16	1252.487
#160	SPDEF	11	6	17	585.457
#161	KLF12	11	7	18	423.028
#162	MYOD1	11	6	17	223.278
#163	ZNF174	11	7	18	426.89
#164	SOLH	11	12	23	781.762
#165	BACH1	11	7	18	217.914
#166	SREBF1	11	10	21	537.384
#167	GSC2	11	10	21	2520.627
#168	HOXB1	11	7	18	1198.194
#169	ZNF434	11	12	23	1879.115
#170	C11orf9	11	9	20	1106.002
#171	NOTCH1	11	3	14	114.435
#172	RCOR1	11	11	22	1256.272
#173	ETS2	11	3	14	113.565
#174	GATA5	11	17	28	1480.314
#175	ZNF197	11	1	12	66.461
#176	L3MBTL4	11	8	19	639.843
#177	ASCL1	11	11	22	401.153
#178	IKZF3	11	8	19	1211.963
#179	SOX1	11	7	18	3669.931
#180	KCNH8	11	15	26	4480.913
#181	NR1I2	11	5	16	432.581
#182	MTF1	10	12	22	2488.28
#183	IRX5	10	6	16	4962.831
#184	NKX2-1	10	12	22	2400.645
#185	STAT3	10	12	22	1956.082
#186	ATF6	10	4	14	564.853
#187	UBN1	10	10	20	812.594
#188	TCF7L2	10	16	26	465.686
#189	NPAS1	10	8	18	305.6
#190	MESP1	10	9	19	733.953
#191	NR1I3	10	10	20	2332.265
#192	ZIC5	10	9	19	1157.923
#193	TCF15	10	10	20	907.412
#194	ETV6	10	9	19	1381.965
#195	CNOT7	10	5	15	141.186
#196	PHF5A	10	15	25	3731.599
#197	IRX3	10	15	25	4005.808
#198	NFYA	10	5	15	236.222
#199	NFIX	10	11	21	1932.47
#200	ZNF445	10	10	20	999.541
#201	CREB5	10	10	20	2224.119
#202	PROX1	10	12	22	4663.774
#203	C1orf85	10	13	23	4238.259
#204	HOXC8	10	9	19	1118.012
#205	E4F1	10	11	21	4475.841
#206	NKX2-3	9	12	21	4832.68
#207	SIX6	9	15	24	566.613
#208	TLX1	9	4	13	320.232
#209	JUNB	9	8	17	617.821
#210	DMRT2	9	9	18	1558.566
#211	TAF12	9	3	12	1098.006
#212	GTF2I	9	12	21	6355.753
#213	CTCF	9	5	14	141.032
#214	ZNF217	9	10	19	301.855
#215	GATA6	9	14	23	2655.749
#216	ETV5	9	9	18	828.005
#217	GATA2	9	14	23	607.06
#218	XBP1	9	4	13	125.503
#219	TARDBP	9	10	19	546.892
#220	PRDM1	9	15	24	2808.54
#221	FBXW7	9	9	18	2291.608
#222	KDM5B	9	15	24	689.258
#223	ELF2	9	10	19	418.229
#224	SCAND3	9	9	18	488.376
#225	RFX1	9	11	20	2170.265
#226	SATB2	9	13	22	1557.456
#227	JUND	9	10	19	1699.083
#228	IRX4	9	13	22	940.911
#229	SCRT2	9	15	24	2553.973
#230	HOXD8	9	13	22	1952.686
#231	ZNF138	9	4	13	50.925
#232	MZF1	9	11	20	591.642
#233	SOX15	9	8	17	1361.94
#234	HMG20A	9	2	11	68.91
#235	MKX	9	8	17	1107.518
#236	SOX30	9	10	19	1893.878
#237	SIX4	9	11	20	3579.088
#238	ZSCAN2	9	10	19	1734.702
#239	IRF7	9	12	21	320.498
#240	ZFPM2	9	14	23	570.579
#241	NPAS2	8	16	24	744.157
#242	NANOG	8	4	12	313.355
#243	GSC	8	5	13	256.47
#244	NPAT	8	13	21	2066.501
#245	ARX	8	9	17	686.624
#246	HNRNPAB	8	2	10	19.529
#247	ZNF157	8	8	16	954.981
#248	ARNTL2	8	7	15	504.987
#249	SIM2	8	10	18	1441.218
#250	MECOM	8	10	18	449.838
#251	TCFL5	8	13	21	1652.621
#252	WNT5A	8	18	26	3002.324
#253	HOXB4	8	14	22	365.705
#254	IRF3	8	12	20	1691.938
#255	PLAG1	8	10	18	1608.356
#256	SP1	8	6	14	179.285
#257	FOXQ1	8	11	19	252.858
#258	NR3C1	8	19	27	1379.885
#259	MAFA	8	6	14	723.989
#260	BATF2	8	7	15	580.633
#261	RXRG	8	9	17	566.303
#262	SMAD9	8	6	14	324.676
#263	ZNF189	8	13	21	4361.82
#264	NFE2L3	8	14	22	2263.335
#265	TGIF2LY	8	10	18	737.116
#266	FOXP4	8	10	18	1193.007
#267	TCF7L1	8	15	23	2151.645
#268	SOX2	8	6	14	810.065
#269	HOXC10	8	13	21	357.707
#270	NR5A1	8	14	22	2839.079
#271	RUNX2	7	6	13	2206.115
#272	LHX3	7	10	17	2184.839
#273	ZNF236	7	8	15	476.132
#274	HNF1A	7	9	16	1057.809
#275	ZNF133	7	16	23	2476.027
#276	HSF2	7	6	13	434.405
#277	NR2F2	7	13	20	1796.292
#278	TWIST1	7	17	24	1018.876
#279	MLLT10	7	12	19	102.07
#280	TGIF2	7	8	15	916.066
#281	NEUROD1	7	10	17	630.049
#282	E2F4	7	9	16	2112.301
#283	FOXM1	7	9	16	654.571
#284	ATF4	7	15	22	4546.93
#285	GATA3	7	11	18	910.11
#286	RAX2	7	4	11	185.248
#287	ZNF37A	7	9	16	2563.958
#288	SALL1	7	8	15	1311.178
#289	ZNF446	7	8	15	743.093
#290	TFAM	7	7	14	762.441
#291	SRY	7	13	20	2803.833
#292	ZNF90	7	14	21	1620.411
#293	SRF	7	12	19	1049.678
#294	MEIS2	7	8	15	442.896
#295	ZNF192	7	16	23	867.661
#296	TP73	7	8	15	445.259
#297	NCOR1	7	5	12	271.849
#298	YY1	7	13	20	1571.508
#299	STAT5A	7	13	20	4272.696
#300	STAT5B	7	6	13	950.447
#301	SUPT4H1	7	15	22	1903.722
#302	ASCL2	7	6	13	172.762
#303	POU4F3	7	6	13	2879.337
#304	MYT1L	7	9	16	590.136
#305	SOX12	7	12	19	1210.54
#306	TCF7	7	11	18	770.966
#307	RHOXF2	7	12	19	2940.968
#308	TFAP2C	7	12	19	2568.41
#309	SOX13	7	11	18	4210.716
#310	ATF2	6	14	20	1044.627
#311	E2F2	6	8	14	222.142
#312	ELF5	6	10	16	1213.062
#313	FOSL1	6	6	12	1076.46
#314	ZBTB48	6	19	25	2912.631
#315	NEUROD2	6	8	14	1644.526
#316	SPEN	6	12	18	4793.299
#317	ZNF277	6	12	18	534.589
#318	RFX3	6	12	18	1595.625
#319	FOXP2	6	11	17	921.445
#320	EBF1	6	7	13	951.31
#321	RHOXF2B	6	17	23	1667.873
#322	TP63	6	10	16	684.187
#323	TLX2	6	10	16	255.14
#324	GAS7	6	15	21	3001.052
#325	MSL3	6	10	16	590.126
#326	HOXC9	6	16	22	1365.005
#327	IRF2	6	15	21	1694.003
#328	TEAD3	6	11	17	832.399
#329	MLX	6	8	14	534.516
#330	ZSCAN29	6	10	16	1857.509
#331	ETV3L	6	8	14	480.255
#332	CNBP	6	5	11	142.677
#333	TAL1	6	11	17	534.686
#334	TCF20	6	11	17	962.558
#335	KLF2	6	12	18	1404.87
#336	NME2	6	15	21	1410.898
#337	POU2F1	6	14	20	1441.609
#338	TAF7	6	15	21	4919.482
#339	ZFP37	6	8	14	1031.505
#340	KLF3	6	16	22	1147.346
#341	ZNF134	6	4	10	343.574
#342	ZNF154	6	14	20	1242.511
#343	ZNF207	6	7	13	643.624
#344	DLX4	6	14	20	1211.17
#345	TADA2A	6	9	15	1455.019
#346	MSX2	6	8	14	951.377
#347	SOX5	6	16	22	2027.85
#348	HOXB3	6	17	23	1559.157
#349	ERG	6	13	19	337.229
#350	TSHZ1	5	11	16	977.574
#351	LEF1	5	8	13	3076.052
#352	GRHL3	5	14	19	576.348
#353	MYF5	5	13	18	3989.003
#354	E2F6	5	12	17	704.864
#355	GRHL2	5	11	16	869.111
#356	TEAD1	5	10	15	569.977
#357	TRIM22	5	12	17	423.492
#358	SUPT6H	5	7	12	4185.271
#359	BTAF1	5	13	18	2979.593
#360	AR	5	14	19	1159.333
#361	HOXA4	5	8	13	532.971
#362	ZNF91	5	9	14	382.05
#363	TFDP2	5	7	12	784.109
#364	RELB	5	12	17	416.165
#365	KLF9	5	11	16	230.745
#366	THRA	5	9	14	547.985
#367	FOXK1	5	9	14	575.733
#368	HES6	5	8	13	634.203
#369	ZNF83	5	11	16	2110.146
#370	TBR1	5	14	19	1553.111
#371	DLX2	5	6	11	177.062
#372	SMAD3	5	15	20	1192.374
#373	ZNF323	5	12	17	584.074
#374	ZNF238	5	15	20	2575.411
#375	MEIS3	5	13	18	578.26
#376	CBFB	5	10	15	816.965
#377	ZIC3	5	12	17	621.648
#378	CSRNP3	5	7	12	441.765
#379	ZSCAN16	5	10	15	2887.563
#380	HES1	5	8	13	4579.707
#381	FOXO4	5	16	21	2813.886
#382	PITX2	4	12	16	660.318
#383	PPARG	4	13	17	2332.199
#384	NFX1	4	7	11	1248.429
#385	ZNF33A	4	14	18	7334.895
#386	LCOR	4	16	20	513.085
#387	CREBL2	4	13	17	392.903
#388	PAX7	4	12	16	1490.861
#389	ESRRA	4	9	13	835.988
#390	VSX1	4	12	16	9558.695
#391	TRIM25	4	7	11	366.987
#392	RUNX1	4	13	17	496.309
#393	KLF4	4	10	14	1499.225
#394	SCML2	4	9	13	218.114
#395	FOXH1	4	14	18	503.987
#396	NFYB	4	13	17	699.376
#397	GBX1	4	7	11	391.042
#398	ZXDC	4	13	17	1366.801
#399	EVX1	4	12	16	1228.754
#400	HOXD1	4	12	16	1146.348
#401	POU2F2	4	14	18	321.566
#402	ESR1	4	14	18	1588.801
#403	ZC3H8	4	10	14	1254.915
#404	HSF4	4	6	10	298.391
#405	FOXC2	4	17	21	1055.934
#406	JDP2	4	9	13	143.26
#407	ZNF69	4	15	19	1242.406
#408	GTF2H4	4	6	10	395.771
#409	POU1F1	4	12	16	568.474
#410	HIRA	4	5	9	844.581
#411	ZNF167	4	10	14	3270.742
#412	CUX2	4	9	13	4760.177
#413	YEATS4	4	15	19	935.345
#414	MBD1	4	5	9	54.368
#415	RORB	4	6	10	441.719
#416	ZNF397	4	16	20	1051.283
#417	ST18	4	11	15	1339.85
#418	E2F5	4	11	15	1030.282
#419	SPIC	4	12	16	1150.01
#420	GABPB1	4	13	17	568.195
#421	NFATC3	4	6	10	171.981
#422	FLI1	3	9	12	51.731
#423	CREB3L3	3	8	11	1012.653
#424	ELK1	3	9	12	63.539
#425	SCML1	3	16	19	596.538
#426	HOXC6	3	10	13	314.713
#427	ETV1	3	15	18	676.044
#428	ZNF496	3	10	13	562.282
#429	TFEB	3	10	13	135.389
#430	PRDM2	3	11	14	941.468
#431	ZNF639	3	11	14	387.481
#432	KLF15	3	17	20	2421.793
#433	MLL	3	11	14	2227.136
#434	DLX6	3	10	13	1956.353
#435	HOXB7	3	19	22	4640.751
#436	MTA3	3	10	13	387.174
#437	HOXA1	3	13	16	1082.553
#438	ELF4	3	9	12	362.764
#439	ENO1	3	10	13	789.879
#440	TFEC	3	17	20	1508.725
#441	HMG20B	3	14	17	1104.012
#442	EMX1	3	12	15	605.445
#443	FOXI1	3	13	16	3103.456
#444	MSRB2	3	15	18	130.176
#445	FOXN2	3	8	11	291.973
#446	HDAC1	3	10	13	538.364
#447	ZNF92	3	11	14	797.268
#448	ZNF213	3	15	18	884.585
#449	PEG3	3	12	15	1495.328
#450	PPARD	2	20	22	943.157
#451	ZSCAN22	2	15	17	367.676
#452	ATF6B	2	10	12	196.747
#453	TPRX1	2	9	11	101.253
#454	TFDP1	2	13	15	390.048
#455	MNX1	2	17	19	472.591
#456	SMAD6	2	15	17	427.884
#457	SOX11	2	14	16	529.931
#458	PGR	2	4	6	542.188
#459	FOXO1	2	13	15	247.004
#460	OVOL1	2	16	18	647.204
#461	C12orf28	2	12	14	1480.316
#462	PBX3	2	15	17	3798.177
#463	ADNP2	2	11	13	362.433
#464	FOXN3	2	17	19	826.541
#465	SP140	2	16	18	980.91
#466	ZNF281	2	13	15	474.989
#467	ZKSCAN1	2	9	11	374.268
#468	CTBP1	2	13	15	1161.732
#469	ELK4	2	12	14	1183.763
#470	RELA	2	13	15	1199.689
#471	LHX1	2	6	8	115.497
#472	BUD31	2	11	13	564.236
#473	PKNOX2	2	10	12	696.221
#474	HCLS1	2	11	13	306.004
#475	TSC22D2	2	10	12	656.699
#476	REXO4	2	9	11	84.032
#477	JUN	1	21	22	1222.362
#478	RFX5	1	13	14	1155.908
#479	ETV7	1	9	10	427.889
#480	SOX21	1	17	18	210.07
#481	TAF1B	1	14	15	173.893
#482	BLZF1	1	11	12	538.463
#483	SOX4	1	10	11	40.407
#484	MTA1	1	11	12	14.681
#485	GATAD1	1	12	13	124.886
#486	TCF4	1	14	15	268.84
#487	EGR3	1	8	9	185.139
#488	ZNF18	1	11	12	445.873
#489	PITX3	1	12	13	283.399
#490	GCM1	1	10	11	47.386
#491	TEAD4	1	8	9	17.716
#492	ZSCAN4	0	15	15	0
#493	TBX19	0	12	12	0
#494	AHCTF1	0	5	5	0
#495	FOXG1	0	10	10	0
#496	POU4F1	0	9	9	0
#497	POU3F2	0	12	12	0
#498	TCF12	0	8	8	0
#499	C5orf41	0	7	7	0
#500	REST	0	8	8	0