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Hub Rank	Node	Children	Parents	Degree	Betweenness
#1	TCF7L1	76	4	80	1182.753
#2	XBP1	70	1	71	7.509
#3	SPDEF	70	3	73	57.649
#4	FOXA1	68	2	70	772.899
#5	FOXC1	63	5	68	56.873
#6	GTF2I	56	2	58	15.485
#7	MBD1	56	1	57	1124.327
#8	GATA3	55	4	59	4462.78
#9	AR	54	8	62	4997.872
#10	ESR1	53	3	56	402.967
#11	ZFP36L2	52	4	56	60.808
#12	RUNX3	51	4	55	321.911
#13	EN1	50	7	57	6967.863
#14	SOX10	49	6	55	69.266
#15	TFDP1	49	7	56	2698.563
#16	PPARA	48	4	52	1031.275
#17	SP1	48	1	49	6.991
#18	RARG	47	5	52	5013.296
#19	PGR	46	9	55	405.547
#20	SOX11	45	11	56	668.535
#21	CREB3L4	45	2	47	17.337
#22	FOXM1	45	8	53	826.166
#23	KLF5	44	10	54	1476.735
#24	RXRB	43	8	51	213.983
#25	TRIM29	41	12	53	1278.573
#26	HSF1	41	6	47	147.806
#27	BCL3	39	9	48	248.173
#28	IRF6	39	5	44	550.257
#29	STAT1	38	13	51	4295.345
#30	MSX2	38	11	49	201.636
#31	AEBP1	37	11	48	800.922
#32	HOXA3	37	11	48	315.639
#33	GATA2	36	9	45	1397.449
#34	NFE2L3	35	10	45	1428.188
#35	CDKN2A	35	11	46	8556.792
#36	HOXB6	34	6	40	1036.578
#37	LASS6	34	10	44	699.277
#38	SOX6	34	9	43	113.106
#39	TRERF1	33	14	47	308.812
#40	FOXO3	33	10	43	215.754
#41	SOX8	33	8	41	76.071
#42	MYC	33	12	45	328.417
#43	IRX1	33	9	42	110.048
#44	MYBL2	33	10	43	639.038
#45	IRX5	33	11	44	14016.033
#46	ANKRD30A	32	12	44	8483.248
#47	EHF	32	17	49	2991.803
#48	HOXA7	32	8	40	1349.719
#49	MMP14	31	8	39	595.435
#50	PRRX2	31	11	42	505.499
#51	SPIB	31	7	38	175.947
#52	NR2F6	31	10	41	657.962
#53	ARNTL2	30	9	39	112.423
#54	PRRX1	30	7	37	229.162
#55	CTNNB1	30	11	41	1294.801
#56	FOXQ1	29	12	41	2459.661
#57	ZEB1	29	11	40	699.774
#58	ALS2CR8	29	13	42	433.459
#59	HOXA5	28	6	34	262.505
#60	MEOX1	28	11	39	2335.291
#61	HIC1	28	7	35	205.209
#62	MLL	28	8	36	111.087
#63	BHLHE40	28	10	38	3053.515
#64	ZNF446	28	9	37	124.729
#65	AHCTF1	28	7	35	134.299
#66	HOXA1	27	15	42	570.668
#67	BTG2	27	13	40	1460.152
#68	NR5A2	27	14	41	1789.945
#69	NR4A2	27	18	45	2384.757
#70	TFE3	27	8	35	107.314
#71	ESRRG	26	15	41	1128.962
#72	FOSL2	26	13	39	3775.948
#73	DMRT1	26	9	35	8441.083
#74	TEAD1	25	14	39	2200.835
#75	TFAP2C	25	14	39	4433.577
#76	BATF2	25	9	34	3709.145
#77	HOXB7	25	10	35	946.207
#78	RARB	25	13	38	463.483
#79	FOXP2	25	16	41	1477.989
#80	NR2F1	24	14	38	766.329
#81	NKX3-1	24	12	36	3209.103
#82	HOXC10	24	14	38	1008.48
#83	HOXA9	24	6	30	588.881
#84	MEIS1	24	16	40	1285.069
#85	GLIS3	24	9	33	627.769
#86	HOXB3	24	10	34	1400.145
#87	LEF1	24	17	41	945.771
#88	TP63	23	17	40	1078.28
#89	SCML1	23	20	43	3896.098
#90	TP53	23	12	35	392.543
#91	SPI1	23	14	37	822.194
#92	TEAD2	23	10	33	6372.929
#93	FOS	23	8	31	1832.89
#94	RORC	23	17	40	516.857
#95	CSRNP3	23	19	42	1734.89
#96	TCF3	22	12	34	392.698
#97	CSDA	22	15	37	3379.782
#98	NFATC4	22	20	42	542.845
#99	RUNX2	22	10	32	198.993
#100	HOXC11	22	14	36	942.211
#101	IKZF1	22	23	45	11624.732
#102	MNX1	22	19	41	1586.107
#103	ETV4	22	18	40	1831.731
#104	KLF4	22	14	36	3255.131
#105	PAX6	21	17	38	1485.866
#106	ZNF71	21	12	33	262.691
#107	WNT5A	21	18	39	1043.172
#108	C12orf28	21	16	37	559.89
#109	MYCN	21	19	40	1808.912
#110	ETV7	21	7	28	2648.698
#111	CREB3L1	21	10	31	1095.892
#112	SOX9	21	11	32	771.159
#113	PITX1	21	22	43	1464.67
#114	TFAP2B	21	20	41	574.308
#115	HOXA4	21	9	30	849.739
#116	PITX2	21	18	39	1379.553
#117	SUPT6H	20	13	33	2670.433
#118	ELF5	20	11	31	137.007
#119	SLC26A3	20	16	36	1584.266
#120	FOSB	20	10	30	985.158
#121	SIX3	20	12	32	183.268
#122	IRX2	20	16	36	6364.926
#123	ASCL2	20	20	40	2339.217
#124	SMAD3	20	14	34	762.153
#125	ZNF92	20	13	33	192.947
#126	HOXB2	20	14	34	339.6
#127	FOXD3	20	17	37	1386.941
#128	BHLHE41	20	20	40	1985.652
#129	HEY1	20	17	37	2105.85
#130	SNAPC5	20	21	41	1567.269
#131	TWIST2	20	19	39	1256.226
#132	PAX3	19	19	38	2958.635
#133	RARA	19	13	32	218.615
#134	DLX6	19	15	34	627.775
#135	TGIF2LY	19	14	33	2333.689
#136	ZNF117	19	11	30	677.296
#137	MESP1	19	10	29	1061.808
#138	PEG3	19	27	46	2370.081
#139	TFCP2L1	19	17	36	2523.3
#140	FOXL1	19	11	30	189.259
#141	STAT2	19	10	29	722.219
#142	SALL1	19	22	41	727.503
#143	SMAD2	19	12	31	137.403
#144	MLLT10	19	20	39	2185.407
#145	HR	18	9	27	115.66
#146	ETV6	18	16	34	973.182
#147	FOSL1	18	14	32	396.562
#148	WT1	18	20	38	1206.325
#149	TFAP2D	18	18	36	1749.12
#150	ZNF238	18	10	28	172.595
#151	PPARG	18	15	33	409.081
#152	NR3C2	18	15	33	581.103
#153	ZBTB17	18	10	28	85.014
#154	NPAS2	18	16	34	547.457
#155	ZNF41	18	13	31	770.327
#156	GRHL3	18	16	34	533.759
#157	THRA	18	19	37	1747.464
#158	RUNX1T1	18	14	32	787.504
#159	POU4F1	18	17	35	885.565
#160	ONECUT2	18	24	42	2034.801
#161	MXD1	18	11	29	232.69
#162	GATA4	18	17	35	2280.483
#163	NFIX	17	16	33	398.088
#164	OVOL1	17	23	40	1156.542
#165	ALX4	17	19	36	1778.418
#166	RORB	17	19	36	612.238
#167	SREBF1	17	9	26	146.191
#168	HMX2	17	21	38	1068.673
#169	ARNT2	17	22	39	3155.821
#170	DLX4	17	16	33	968.892
#171	MYT1	17	17	34	4655.819
#172	TAF13	17	18	35	1157.723
#173	SIX1	17	19	36	931.902
#174	FOXI1	17	20	37	2460.475
#175	HES6	17	20	37	1713.399
#176	MEIS3	17	19	36	838.633
#177	NOTCH1	16	15	31	474.223
#178	ZNF131	16	17	33	1070.099
#179	BNC1	16	14	30	1021.272
#180	ETV1	16	19	35	1198.403
#181	RXRG	16	15	31	1282.894
#182	ATF2	16	8	24	456.981
#183	ST18	16	18	34	991.543
#184	GATA6	16	15	31	1460.441
#185	SOX2	16	24	40	2458.901
#186	HOXC5	16	20	36	967.595
#187	POU3F2	16	22	38	1088.529
#188	TFDP3	16	13	29	724.03
#189	PURA	16	11	27	1162.523
#190	BARX1	15	15	30	334.131
#191	SP3	15	13	28	517.496
#192	ARX	15	26	41	1690.469
#193	KCNH8	15	13	28	542.739
#194	TBX2	15	17	32	626.663
#195	HSF5	15	22	37	4174.292
#196	HOXB8	15	15	30	2037.229
#197	CUX2	15	16	31	3816.24
#198	SOX15	15	18	33	827.568
#199	TBX5	15	12	27	916.403
#200	ZNF81	15	20	35	1217.766
#201	ZFHX2	15	12	27	548.239
#202	POU2F1	15	14	29	751.43
#203	MLX	15	11	26	1084.433
#204	MYT1L	15	20	35	1223.353
#205	ELK1	15	15	30	851.959
#206	MESP2	15	15	30	968.192
#207	POU6F1	15	16	31	1426.97
#208	GSC	15	16	31	606.731
#209	ZNF132	15	23	38	1114.841
#210	EGR1	15	16	31	311.355
#211	LHX9	15	19	34	1651.567
#212	NR0B1	15	17	32	1376.481
#213	STRN3	15	21	36	1543.551
#214	LASS5	15	21	36	1627.31
#215	RFX3	15	19	34	1072.992
#216	FOXN4	15	21	36	1320.364
#217	ZSCAN12	15	22	37	1050.719
#218	HEY2	15	20	35	691.598
#219	RELA	15	18	33	1380.033
#220	FOXG1	15	15	30	380.827
#221	ENO1	15	16	31	453.86
#222	SCAND3	15	14	29	1919.665
#223	NKX2-3	15	18	33	1402.385
#224	ATF6B	14	19	33	960.224
#225	IRF5	14	17	31	1161.046
#226	ETS2	14	15	29	612.937
#227	NANOG	14	25	39	911.033
#228	PKNOX1	14	11	25	277.154
#229	MZF1	14	21	35	623.303
#230	FOXA2	14	22	36	3631.249
#231	ZNF85	14	16	30	1021.627
#232	NR2E3	14	22	36	609.888
#233	MTA2	14	15	29	394.709
#234	EMX1	14	22	36	891.104
#235	POU3F1	14	15	29	731.717
#236	C11orf9	14	18	32	643.638
#237	ATF3	14	13	27	137.237
#238	LMO4	14	14	28	1752.125
#239	RFXAP	14	11	25	187.521
#240	HLF	14	20	34	637.308
#241	ASCL1	14	15	29	486.782
#242	ZSCAN20	14	16	30	1128.727
#243	SOX5	14	19	33	1776.579
#244	FOXR2	14	20	34	1631.373
#245	ZIC2	14	20	34	1097.325
#246	PLSCR1	14	20	34	1281.35
#247	FOXD1	14	17	31	906.762
#248	HES5	14	16	30	986.75
#249	PROX1	13	20	33	361.281
#250	TSC22D3	13	19	32	1480.227
#251	GCM1	13	18	31	2833.331
#252	ZEB2	13	20	33	802.074
#253	PAX7	13	19	32	1461.554
#254	L3MBTL4	13	15	28	1040.409
#255	HNF4G	13	18	31	615.407
#256	ZHX2	13	21	34	3487.318
#257	FOXJ1	13	17	30	800.355
#258	GLI2	13	21	34	1380.921
#259	NFIB	13	13	26	3283.65
#260	RCAN1	13	18	31	783.221
#261	LMX1B	13	14	27	551.656
#262	FOXP3	13	17	30	590.994
#263	NKX2-8	13	16	29	880.939
#264	NFE2	13	19	32	1277.552
#265	DMRT2	13	20	33	2143.884
#266	HOXD4	13	24	37	837.702
#267	DMBX1	13	20	33	874.366
#268	SIX2	13	22	35	1330.309
#269	NKX2-5	13	16	29	282.06
#270	GLI3	13	21	34	934.067
#271	VDR	13	17	30	1950.54
#272	ZNF483	13	18	31	1581.032
#273	NFE2L2	13	19	32	1021.348
#274	ZSCAN2	12	22	34	1084.761
#275	SNAI3	12	15	27	1029.612
#276	HIRA	12	19	31	1302.382
#277	HIF3A	12	18	30	1096.508
#278	MECOM	12	23	35	1483.178
#279	ZNF135	12	29	41	1631.892
#280	NPAS1	12	24	36	1525.319
#281	FOXF1	12	15	27	887.377
#282	DLX2	12	19	31	1018.985
#283	NEUROG1	12	21	33	1367.247
#284	VTN	12	18	30	1007.203
#285	ZNF169	12	13	25	727.291
#286	HOXA11	12	11	23	407.224
#287	TFAP2A	12	18	30	576.059
#288	ELK4	12	19	31	1012.723
#289	TBR1	12	18	30	1063.948
#290	KLF17	12	14	26	1317.573
#291	REST	12	14	26	523.748
#292	TBX10	11	16	27	1170.224
#293	BLZF1	11	18	29	856.751
#294	CITED1	11	13	24	185.255
#295	TP73	11	18	29	687.225
#296	LHX8	11	20	31	673.577
#297	YY1	11	14	25	379.748
#298	HNF1A	11	17	28	1087.847
#299	C2orf3	11	22	33	1164.762
#300	TBX22	11	24	35	1004.23
#301	HNF4A	11	19	30	1151.046
#302	SCAND1	11	13	24	421.41
#303	NEUROD1	11	23	34	1124.316
#304	AFF4	11	22	33	1257.443
#305	FOXC2	11	18	29	997.325
#306	ZNF397	11	22	33	1232.436
#307	TCF21	11	23	34	992.418
#308	DLX1	11	16	27	621.059
#309	FOXD2	11	16	27	512.356
#310	PHOX2B	11	20	31	910.16
#311	LZTS1	11	16	27	684.04
#312	BCL11B	11	16	27	535.308
#313	HOXB13	11	24	35	2025.499
#314	SIX4	11	20	31	1368.414
#315	STAT5B	11	20	31	1363.884
#316	TBX3	11	18	29	882.051
#317	ZIC1	11	13	24	190.113
#318	ZNF33B	11	16	27	741.89
#319	PPARD	11	16	27	784.241
#320	NKX6-1	11	18	29	950.892
#321	HOXD10	11	17	28	756.873
#322	TSC22D2	11	18	29	919.248
#323	MKX	11	23	34	872.918
#324	LHX2	11	20	31	1022.232
#325	FUBP1	11	20	31	1229.739
#326	TADA3	11	20	31	1409.549
#327	SCAND2	11	18	29	494.141
#328	ATF7	11	17	28	349.339
#329	EGR4	11	22	33	1032.327
#330	NR5A1	11	15	26	1906.185
#331	HOXC12	11	17	28	613.47
#332	SOX1	11	21	32	787.166
#333	NR2E1	11	21	32	830.896
#334	MLXIPL	11	19	30	747.855
#335	RUNX1	11	15	26	304.867
#336	HOXD11	11	21	32	883.529
#337	CBL	10	17	27	602.169
#338	HOXD13	10	18	28	986.706
#339	HOXA2	10	14	24	802.909
#340	ZXDC	10	18	28	849.259
#341	OLIG2	10	15	25	1288.2
#342	ZSCAN18	10	18	28	1130.033
#343	HOXD1	10	16	26	1090.519
#344	BRD8	10	24	34	1247.185
#345	POU5F2	10	23	33	1070.161
#346	HOXB1	10	20	30	926.205
#347	SEBOX	10	19	29	816.603
#348	KLF9	10	22	32	1052.23
#349	PAX8	10	20	30	677.539
#350	HOXD3	10	20	30	532.293
#351	MYCL1	10	17	27	1713.166
#352	ALX3	10	19	29	600.139
#353	SPIC	10	16	26	784.386
#354	GBX2	10	17	27	860.485
#355	CREM	10	27	37	2631.612
#356	CTBP1	10	18	28	662.095
#357	SATB2	10	20	30	774.122
#358	NFATC2	10	20	30	1551.894
#359	FOXE1	10	20	30	584.219
#360	TADA2A	10	16	26	837.161
#361	TBX20	10	22	32	1194.439
#362	SMAD6	10	22	32	800.733
#363	KDM5B	10	23	33	1348.828
#364	LMX1A	10	17	27	539.275
#365	HOPX	10	15	25	1080.09
#366	IRX4	10	21	31	1168.648
#367	ISL1	9	20	29	582.472
#368	PDX1	9	19	28	1159.686
#369	HMG20B	9	21	30	825.289
#370	SIX6	9	20	29	1141.927
#371	ZNF90	9	16	25	479.485
#372	ALX1	9	15	24	258.7
#373	ESR2	9	21	30	2588.136
#374	ONECUT1	9	20	29	1521.797
#375	MITF	9	17	26	594.677
#376	EN2	9	19	28	716.96
#377	NOBOX	9	17	26	723.366
#378	ESX1	9	16	25	782.778
#379	NR1H4	9	18	27	851.261
#380	PAX5	9	18	27	1598.704
#381	SLC2A4RG	9	15	24	700.535
#382	TSHZ2	9	20	29	561.786
#383	PKNOX2	9	23	32	934.014
#384	IKZF3	9	19	28	745.836
#385	ZNF496	9	13	22	354.048
#386	MYF5	9	17	26	854.013
#387	CREBBP	9	23	32	1405.971
#388	SRY	9	14	23	824.523
#389	NCOR1	9	19	28	1296.83
#390	NFYA	9	17	26	877.026
#391	POU3F3	9	23	32	858.92
#392	HOXC13	9	13	22	2114.992
#393	HOXA10	9	11	20	216.595
#394	JUND	9	17	26	626.959
#395	SP4	9	18	27	910.456
#396	NRL	9	21	30	684.388
#397	GATAD1	9	17	26	632.396
#398	NPAT	8	22	30	922.701
#399	USF1	8	14	22	583.094
#400	E2F2	8	18	26	562.82
#401	NFKB2	8	20	28	1032.819
#402	KLF12	8	21	29	1199.83
#403	GATA5	8	26	34	644.121
#404	PAX4	8	20	28	594.497
#405	ZSCAN1	8	23	31	1222.452
#406	FOXA3	8	19	27	656.025
#407	NR1I3	8	22	30	2526.311
#408	ZNF80	8	18	26	708.926
#409	TLX1	8	15	23	186.028
#410	PCGF2	8	20	28	937.577
#411	TBX1	8	28	36	875.143
#412	SIM1	8	24	32	1003.939
#413	ZNF93	8	29	37	1218.931
#414	FOXK1	8	20	28	556.806
#415	POU1F1	8	17	25	896.148
#416	TBX6	8	20	28	1041.023
#417	ISX	8	22	30	1377.149
#418	SP140	8	21	29	873.673
#419	NEUROD2	8	16	24	599.458
#420	HCFC1	8	20	28	1878.466
#421	HOXA13	8	24	32	829.294
#422	NFATC1	8	14	22	75.847
#423	HAND2	8	19	27	724.864
#424	SIM2	8	23	31	765.668
#425	MYF6	8	19	27	666.432
#426	HESX1	8	20	28	601.659
#427	ZNF175	8	20	28	617.474
#428	NFIA	8	20	28	1118.278
#429	TEF	8	13	21	288.321
#430	CLOCK	7	24	31	962.659
#431	TFAP4	7	19	26	1085.233
#432	MIXL1	7	17	24	468.848
#433	DLX3	7	19	26	593.648
#434	FOXH1	7	21	28	614.212
#435	TAL1	7	18	25	787.47
#436	FLI1	7	19	26	423.257
#437	LHX1	7	14	21	3117.356
#438	ZIC5	7	21	28	473.884
#439	ZIC3	7	15	22	866.889
#440	ZSCAN4	7	19	26	630.421
#441	GSX2	7	21	28	1071.621
#442	TCF20	7	18	25	375.77
#443	NFYC	7	20	27	350.341
#444	POU4F2	7	22	29	700.245
#445	ZFP42	7	19	26	1178.924
#446	PRDM2	7	21	28	888.279
#447	ESRRB	7	19	26	607.45
#448	FOXO1	7	24	31	910.138
#449	ZNF287	7	19	26	1535.7
#450	POU4F3	7	22	29	722.702
#451	IRF4	7	16	23	360.827
#452	SMAD4	7	23	30	676.68
#453	ZHX3	7	18	25	768.703
#454	ZNF207	6	21	27	488.301
#455	TLX3	6	22	28	808.592
#456	MAF	6	20	26	846.017
#457	HMGA2	6	20	26	826.956
#458	NKX6-2	6	23	29	743.462
#459	NKX2-1	6	20	26	831.356
#460	FOXL2	6	16	22	717.259
#461	SIN3A	6	22	28	939.074
#462	ZFHX3	6	17	23	544.527
#463	POU6F2	6	22	28	546.881
#464	ERF	6	21	27	608.324
#465	POU2F2	6	20	26	614.44
#466	RAX2	6	18	24	565.121
#467	SOX21	6	16	22	421.59
#468	RCOR1	5	17	22	253.716
#469	ATOH1	5	19	24	653.124
#470	ISL2	5	27	32	522.04
#471	PBX3	5	15	20	623.684
#472	ZSCAN23	5	21	26	376.758
#473	NR6A1	5	21	26	1175.335
#474	MEOX2	5	16	21	404.017
#475	MYNN	5	19	24	818.628
#476	ZNF157	5	24	29	1184.318
#477	SOX30	5	22	27	470.476
#478	PTH	5	25	30	747.274
#479	CREBZF	5	24	29	698.698
#480	NR4A3	5	15	20	361.514
#481	PURB	5	16	21	376.132
#482	ZKSCAN3	5	18	23	506.201
#483	ZNF215	5	25	30	471.932
#484	POU2F3	5	18	23	483.083
#485	ZNF154	5	20	25	540.181
#486	ZFHX4	5	24	29	558.056
#487	HNRNPAB	5	20	25	444.572
#488	ZFP36L1	5	19	24	356.191
#489	OTX2	5	19	24	1158.368
#490	ETV5	5	15	20	423.475
#491	ZNF396	4	20	24	211.476
#492	EPAS1	4	23	27	470.89
#493	RERE	4	21	25	967.9
#494	GSX1	4	13	17	220.178
#495	VSX1	3	21	24	459.753
#496	GSC2	3	22	25	219.947
#497	CREB3L3	3	25	28	326.594
#498	ARNT	2	22	24	148.76
#499	MGA	2	18	20	246.4
#500	RORA	2	23	25	672.02