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Hub Rank	Node	Children	Parents	Degree	Betweenness
#1	NR0B1	106	10	116	3383.708
#2	CREB3L3	86	8	94	16870.514
#3	VSX1	84	13	97	2709.564
#4	PLSCR1	79	7	86	2117.192
#5	SLC26A3	74	9	83	5302.796
#6	NR5A2	74	19	93	1733.092
#7	NOTCH1	72	10	82	5827.738
#8	NFKB2	71	13	84	974.071
#9	KDM5B	68	17	85	3034.983
#10	ZNF154	66	20	86	2992.216
#11	AFF4	63	11	74	2558.043
#12	TEAD1	61	13	74	4247.48
#13	MAFB	58	2	60	271.364
#14	MSX2	57	17	74	1356.932
#15	ZNF157	57	14	71	888.863
#16	TBR1	56	16	72	1134.8
#17	ONECUT2	56	17	73	954.911
#18	SIN3A	55	17	72	1055.319
#19	SMAD6	54	20	74	2787.227
#20	ZIC1	54	20	74	1281.101
#21	ZNF80	54	21	75	1431.034
#22	ZNF90	53	16	69	1493.428
#23	ZFP42	53	18	71	1705.299
#24	MLL	53	15	68	1240.78
#25	ST18	52	17	69	1757.246
#26	FOXH1	50	6	56	766.234
#27	HOXD3	50	21	71	1814.197
#28	SMAD4	50	19	69	1299.579
#29	TSC22D2	49	16	65	992.1
#30	SOX21	48	21	69	9722.35
#31	PKNOX2	48	23	71	1768.098
#32	POU1F1	47	16	63	1105.389
#33	TBX1	46	15	61	1502.935
#34	TFAP2A	45	22	67	758.275
#35	CNOT7	44	8	52	877.739
#36	RARB	44	18	62	1286.19
#37	NFYA	44	17	61	935.26
#38	DLX4	44	22	66	7702.608
#39	TBX20	43	13	56	791.877
#40	RORB	43	20	63	1079.872
#41	NANOG	42	17	59	808.967
#42	EPAS1	42	3	45	803.725
#43	HNF4A	41	20	61	2693.807
#44	TFAP2B	41	27	68	4183.749
#45	GSX1	41	22	63	864.703
#46	HOXB8	40	23	63	729.435
#47	MYF5	40	24	64	1013.563
#48	NFIC	40	18	58	719.859
#49	FOXL2	40	13	53	323.478
#50	NFATC2	40	20	60	875.195
#51	LMX1A	39	19	58	1277.149
#52	HSF4	39	21	60	1566.427
#53	HES5	38	15	53	1945.255
#54	TBX6	37	20	57	931.139
#55	RUNX2	37	22	59	1412.269
#56	TAF4	37	8	45	413.412
#57	STRN3	37	3	40	107.429
#58	TFAP2D	36	22	58	2208.818
#59	ZFPM2	36	1	37	960.09
#60	ESX1	36	20	56	1195.931
#61	HCLS1	36	8	44	888.827
#62	POU2F3	35	21	56	1270.912
#63	ZNF131	34	20	54	487.75
#64	SOX13	34	22	56	1010.02
#65	CREBBP	33	20	53	689.029
#66	TAF7	33	6	39	251.044
#67	NPAT	33	20	53	696.633
#68	POU3F2	33	21	54	1577.059
#69	PRDM2	33	24	57	1346.298
#70	SNAI2	32	4	36	1450.937
#71	HMX1	32	24	56	1220.748
#72	DLX3	32	19	51	421.87
#73	DLX6	32	24	56	621.464
#74	NR2E3	32	21	53	781.104
#75	VTN	31	18	49	706.1
#76	REST	31	18	49	3161.437
#77	FOXA1	31	20	51	650.892
#78	HNF1B	31	19	50	947.19
#79	MKX	31	21	52	1214.565
#80	HOXD1	31	12	43	454.069
#81	ONECUT1	31	22	53	2129.199
#82	E4F1	30	9	39	385.974
#83	NFIA	30	7	37	2874.813
#84	ZNF434	30	12	42	500.75
#85	PPARA	29	21	50	726.206
#86	ATOH1	29	15	44	309.796
#87	HMGB2	29	15	44	513.408
#88	SEBOX	29	14	43	588.754
#89	ZSCAN2	29	25	54	846.71
#90	TSC22D1	28	24	52	980.315
#91	ALX3	28	18	46	449.107
#92	FOXO3	28	22	50	934.739
#93	ESRRB	28	23	51	624.706
#94	ZGPAT	27	8	35	327.152
#95	MYT1L	27	26	53	1174.478
#96	HNF4G	27	18	45	16022.125
#97	MEOX2	27	6	33	3620.921
#98	CNOT8	27	9	36	278.193
#99	PPARD	27	22	49	561.391
#100	ZNF71	27	22	49	514.317
#101	PURA	27	6	33	420.885
#102	BNC1	27	23	50	727.75
#103	ZNF174	26	2	28	223.514
#104	NR2F2	26	9	35	1088.334
#105	PRRX1	25	7	32	884.24
#106	SP3	25	12	37	393.062
#107	FOXE1	24	16	40	11574.083
#108	CEBPA	24	7	31	1077.354
#109	ZIC3	24	22	46	854.677
#110	FOXJ3	24	6	30	211.055
#111	NFIB	24	8	32	362.962
#112	LASS5	23	5	28	95.484
#113	TEF	23	15	38	409.724
#114	TBP	22	7	29	265.768
#115	HOXD11	21	17	38	582.097
#116	ZEB2	21	6	27	247.785
#117	C2orf3	21	21	42	491.574
#118	SMAD1	21	3	24	880.778
#119	NR1H3	21	2	23	13.335
#120	MXD1	21	21	42	601.77
#121	MMP14	21	7	28	758.68
#122	NKX2-1	21	22	43	546.325
#123	MYNN	21	6	27	99.065
#124	ESR1	20	22	42	1539.481
#125	NR2C1	20	6	26	128.329
#126	ZNF483	20	28	48	779.365
#127	TULP4	20	22	42	555.114
#128	TBX5	20	29	49	735.156
#129	ZNF202	19	11	30	372.155
#130	ELK1	19	18	37	3727.021
#131	CCRN4L	19	15	34	2826.126
#132	FOXI1	19	19	38	640.141
#133	IRF3	18	10	28	284.081
#134	MTF1	18	13	31	464.234
#135	NR6A1	18	11	29	278.161
#136	HHEX	17	11	28	18409.429
#137	ARNT	17	16	33	368.983
#138	MAX	17	5	22	210.73
#139	FOSL2	17	11	28	4673.065
#140	RNF4	17	8	25	112.21
#141	RELA	17	8	25	260.462
#142	FOXM1	17	9	26	1286.955
#143	VENTX	17	21	38	407.445
#144	NFYB	17	13	30	893.895
#145	PEG3	16	16	32	216.258
#146	TEAD2	16	2	18	10.383
#147	GCM1	16	18	34	254.748
#148	KLF4	16	7	23	1115.706
#149	TCF7L1	16	11	27	2421.047
#150	TAF5L	15	14	29	541.156
#151	GATA3	15	15	30	1029.12
#152	LHX1	15	19	34	182.563
#153	PBX1	15	8	23	356.98
#154	MAF	15	9	24	1282.586
#155	NFE2L3	15	12	27	931.672
#156	ASCL1	14	17	31	4340.34
#157	HIC1	13	16	29	3810.885
#158	BCL11B	13	12	25	10992.241
#159	ZKSCAN5	13	12	25	253.021
#160	BCL6	13	8	21	15940.608
#161	ZNF3	13	21	34	450.9
#162	TFEC	13	14	27	2369.918
#163	ARNTL2	13	15	28	14289.74
#164	LHX8	13	21	34	480.207
#165	BACH2	13	15	28	13090.278
#166	MLX	13	6	19	109.553
#167	NKX2-5	13	23	36	264.853
#168	GATAD2A	13	22	35	647.084
#169	SOX18	13	13	26	2041.621
#170	TCF20	13	10	23	168.111
#171	FOXP1	12	10	22	4380.989
#172	SNAPC5	12	11	23	123.292
#173	ZSCAN4	12	28	40	3605.068
#174	CTCF	12	13	25	243.158
#175	CNBP	12	13	25	364.428
#176	HINFP	12	12	24	295.538
#177	HNRNPK	11	9	20	129.575
#178	ETS2	11	12	23	577.05
#179	NPAS2	11	17	28	660.026
#180	TWIST1	11	11	22	1947.408
#181	IRF4	11	12	23	10645.868
#182	ZRANB2	11	8	19	84.404
#183	GLIS3	11	11	22	1294.603
#184	MEIS2	11	11	22	893.37
#185	SOX8	11	6	17	2765.045
#186	VDR	11	13	24	3302.401
#187	MECOM	10	13	23	2256.162
#188	ELF3	10	9	19	123.247
#189	CDKN2A	10	11	21	417.033
#190	JUND	10	16	26	813.853
#191	LZTS1	10	13	23	2610.823
#192	ATF6B	10	13	23	1107.06
#193	TSHZ3	10	18	28	1834.386
#194	SUPT4H1	9	11	20	144.244
#195	MYBL2	9	6	15	1155.351
#196	IKZF1	9	11	20	6971.387
#197	TCF7L2	9	8	17	184.506
#198	YY1	9	8	17	53.848
#199	HOXA1	9	14	23	1350.556
#200	MEIS1	9	11	20	1550.561
#201	RFX3	9	12	21	791.008
#202	PPARG	9	9	18	269.97
#203	SOX4	9	12	21	530.083
#204	CEBPD	9	9	18	11025.599
#205	ADNP	9	9	18	58.301
#206	FOSL1	9	16	25	1375.902
#207	HIF3A	9	12	21	918.13
#208	FOXL1	8	13	21	391.938
#209	HCFC1	8	13	21	273.875
#210	HEY2	8	4	12	86.174
#211	OTX2	8	13	21	1095.824
#212	EOMES	8	5	13	35.76
#213	ARNT2	8	7	15	3066.848
#214	RORC	8	13	21	186.252
#215	TBX2	8	14	22	872.563
#216	ZHX3	8	12	20	100.453
#217	TFDP1	8	8	16	1133.218
#218	FOSB	8	5	13	484.497
#219	OLIG2	8	16	24	11558.93
#220	HOXA5	8	14	22	1521.609
#221	FOS	8	12	20	650.478
#222	HOXC9	8	11	19	4511.036
#223	MEOX1	8	13	21	111.305
#224	ETV7	7	17	24	4222.471
#225	HMGB1	7	15	22	251.696
#226	SPEN	7	15	22	5394.623
#227	GLIS2	7	10	17	587.9
#228	SATB2	7	15	22	2041.06
#229	ZNF193	7	14	21	16084.335
#230	ZBTB17	7	12	19	1696.274
#231	NFIX	7	16	23	3597.174
#232	CLOCK	7	16	23	430.677
#233	SLC2A4RG	7	19	26	909.52
#234	LHX6	7	11	18	1236.066
#235	E2F2	7	12	19	689.112
#236	HOXA7	7	12	19	232.681
#237	BACH1	7	10	17	2845.648
#238	RARG	7	13	20	2073.201
#239	SMAD2	7	12	19	231.777
#240	RUNX3	7	13	20	571.354
#241	RORA	7	19	26	3801.179
#242	POU2F1	6	13	19	322.56
#243	NR1H4	6	13	19	165.995
#244	RARA	6	8	14	1411.733
#245	RXRG	6	13	19	159.591
#246	IRX3	6	12	18	372.216
#247	CREB3L2	6	16	22	3895.883
#248	TLX2	6	16	22	552.153
#249	GATA6	6	13	19	3773.394
#250	MESP1	6	10	16	146.532
#251	ZNF45	6	14	20	211.477
#252	PITX1	6	11	17	714.999
#253	SIM2	6	12	18	8263.312
#254	NOBOX	6	17	23	4557.765
#255	HLF	6	12	18	822.858
#256	SIM1	6	8	14	81.138
#257	NPAS1	6	9	15	965.681
#258	ETV1	6	9	15	726.231
#259	ZSCAN18	6	19	25	3226.185
#260	SIX5	6	13	19	890.736
#261	ERG	5	9	14	3727.378
#262	STAT1	5	8	13	646.528
#263	RUNX1T1	5	16	21	508.587
#264	SOX17	5	15	20	1917.712
#265	ZNF33B	5	7	12	859.684
#266	MESP2	5	13	18	2820.195
#267	LASS6	5	14	19	4120.571
#268	MEIS3	5	16	21	656.482
#269	ZNF287	5	17	22	355.16
#270	TBX3	5	12	17	1377.686
#271	FOXD1	5	15	20	704.267
#272	SIX4	5	12	17	294.931
#273	KLF15	5	17	22	2837.888
#274	FOXN3	5	18	23	2118.483
#275	FOXP2	5	10	15	196.985
#276	PAX4	5	13	18	252.348
#277	SOX30	5	12	17	1466.758
#278	TAL1	5	9	14	2736.668
#279	DLX1	5	17	22	244.473
#280	PROX1	5	13	18	2562.414
#281	GAS7	5	19	24	2521.21
#282	NR3C2	5	10	15	2856.962
#283	BARX1	4	14	18	582.602
#284	SOX2	4	17	21	227.555
#285	ETV4	4	17	21	312.589
#286	POU4F1	4	14	18	1738.582
#287	MIXL1	4	12	16	8839.498
#288	TCF3	4	17	21	62.137
#289	HDX	4	10	14	711.164
#290	ZFHX3	4	14	18	75.305
#291	MNT	4	17	21	1231.866
#292	KLF17	4	14	18	2613.417
#293	MNX1	4	13	17	813.809
#294	ELK4	4	16	20	156.924
#295	C11orf9	4	11	15	611.131
#296	RUNX1	4	16	20	261.126
#297	GLI3	4	19	23	497.219
#298	TSHZ2	4	14	18	238.78
#299	ATF3	4	12	16	484.138
#300	GATA4	4	6	10	107.943
#301	SIX1	4	12	16	956.552
#302	ZNF500	4	19	23	2910.657
#303	JUN	4	15	19	363.276
#304	BCL3	4	15	19	4731.904
#305	TGIF1	4	10	14	2386.257
#306	EMX1	4	8	12	566.516
#307	ZSCAN12	4	15	19	985.294
#308	NRL	4	17	21	185.774
#309	EHF	4	18	22	1410.991
#310	DMRT1	4	8	12	35.728
#311	SOX7	4	13	17	546.798
#312	PCGF2	4	15	19	489.874
#313	NEUROD1	4	15	19	77.299
#314	ISL2	4	13	17	309.582
#315	ATF5	4	15	19	62.078
#316	ZFP36L1	3	16	19	9449.112
#317	ETV5	3	12	15	326.532
#318	LHX2	3	20	23	757.812
#319	ZNF215	3	17	20	1934.874
#320	BHLHE41	3	14	17	931.069
#321	THRB	3	15	18	227.015
#322	SPIC	3	9	12	58.981
#323	WT1	3	13	16	4530.519
#324	HESX1	3	16	19	45.913
#325	PHOX2B	3	10	13	25.725
#326	CUX2	3	12	15	461.903
#327	TCF21	3	15	18	431.447
#328	HEY1	3	12	15	3078.363
#329	PAX8	3	15	18	51.674
#330	NANOGNB	3	10	13	78.401
#331	ZSCAN1	3	15	18	792.699
#332	NR5A1	3	16	19	164.688
#333	CSDA	3	15	18	105.032
#334	ALX4	3	9	12	39.478
#335	CREB3L1	3	13	16	2093.814
#336	HMGA2	3	11	14	79.118
#337	PURB	3	15	18	175.678
#338	SIX3	3	18	21	279.587
#339	FOXK1	3	18	21	44.619
#340	RBPJL	3	12	15	767.26
#341	FOXO1	3	13	16	460.714
#342	IRX5	3	13	16	53.669
#343	CTBP1	3	18	21	2406.796
#344	TADA2A	3	17	20	2980.903
#345	PBX4	3	15	18	195.28
#346	HOXB9	3	17	20	431.582
#347	PDX1	3	17	20	3071.574
#348	TFE3	3	9	12	442.853
#349	NR4A1	3	10	13	165.767
#350	HOXA4	3	9	12	99.559
#351	TCF7	3	9	12	302.993
#352	ALS2CR8	3	11	14	49.844
#353	ZSCAN10	3	8	11	37.506
#354	GRHL2	3	10	13	677.493
#355	EN1	3	14	17	205.33
#356	MLXIPL	3	4	7	136.315
#357	SREBF1	2	11	13	2281.558
#358	SCRT1	2	14	16	27.683
#359	BHLHE40	2	10	12	324.805
#360	HOXB1	2	17	19	234.615
#361	SOX1	2	13	15	235.113
#362	MSX1	2	19	21	10181.391
#363	FOXC1	2	10	12	157.416
#364	NR1I2	2	12	14	27.5
#365	IRX1	2	11	13	140.444
#366	ZIC5	2	15	17	98.398
#367	MYCN	2	11	13	149.46
#368	HOXA9	2	11	13	150.441
#369	MYCL1	2	13	15	3922.539
#370	NEUROD2	2	9	11	2092.007
#371	IRF5	2	13	15	843.876
#372	EN2	2	15	17	85.492
#373	TSC22D3	2	16	18	2287.632
#374	FOXK2	2	12	14	489.733
#375	RCAN1	2	17	19	37.075
#376	ESR2	2	16	18	509.535
#377	KDM5A	2	8	10	516.835
#378	HOXA2	2	14	16	361.042
#379	TFAP2C	2	15	17	32.552
#380	HOPX	2	12	14	1178.845
#381	PGR	2	13	15	737.653
#382	SOX6	2	13	15	56.295
#383	ARX	2	10	12	72.861
#384	ZNF117	2	13	15	2096.766
#385	TEAD4	2	10	12	594.202
#386	ATF2	2	10	12	297.881
#387	HOXC12	2	13	15	56.085
#388	KLF9	2	16	18	542.439
#389	MLLT10	2	11	13	751.358
#390	ZNF165	2	12	14	1377.485
#391	ZNF19	2	14	16	38.788
#392	SIX2	2	14	16	658.472
#393	EGR4	2	13	15	127.85
#394	FOXS1	2	10	12	1994.205
#395	CREB5	2	15	17	233.022
#396	ZEB1	2	8	10	1186.149
#397	FOXC2	2	17	19	30.539
#398	WNT5A	2	9	11	16.001
#399	HOXB6	2	14	16	3040.617
#400	HOXD13	2	13	15	56.839
#401	TRERF1	2	15	17	1189.184
#402	PRRX2	2	18	20	774.237
#403	THRA	2	15	17	24.14
#404	ZSCAN20	2	15	17	238.937
#405	KLF12	2	13	15	7890.644
#406	ERF	2	15	17	112.538
#407	NKX3-2	2	12	14	250.105
#408	IKZF4	2	14	16	1626.462
#409	TAF13	2	13	15	595.242
#410	ZKSCAN3	2	11	13	1319.278
#411	ZNF496	2	10	12	114.514
#412	SOX11	2	9	11	18.538
#413	HES6	2	17	19	353.615
#414	ZNF135	2	11	13	3794.273
#415	IRF6	2	15	17	20.887
#416	ZNF397	2	12	14	938.276
#417	FOXG1	2	13	15	116.393
#418	HOXD9	2	13	15	1279.253
#419	ZNF93	2	12	14	502.012
#420	SOX9	2	15	17	1887.756
#421	MBD1	2	11	13	517.899
#422	GLI2	2	10	12	106.31
#423	GATAD1	2	16	18	226.179
#424	HOXB7	1	12	13	2533.011
#425	FOXA3	1	18	19	456.845
#426	PAX5	1	14	15	121.61
#427	T	1	16	17	8.71
#428	ZNF444	1	12	13	1076.718
#429	RERE	1	14	15	142.525
#430	MYT1	1	16	17	150.375
#431	CSRNP3	1	12	13	35.271
#432	BRD8	1	14	15	32.852
#433	ASCL2	1	15	16	333.259
#434	SCAND2	1	17	18	23.665
#435	CREBZF	1	10	11	66.926
#436	ZNF81	1	17	18	65.211
#437	GATA1	1	14	15	471.285
#438	SOX10	1	17	18	62.82
#439	SMAD3	1	18	19	1293.915
#440	SIX6	1	16	17	16.518
#441	HOXC8	1	12	13	43.976
#442	PHOX2A	1	13	14	249.185
#443	L3MBTL4	1	11	12	38.851
#444	PBX3	1	13	14	99.279
#445	BARHL1	1	11	12	6.546
#446	DMRT2	1	11	12	179.113
#447	ZSCAN23	1	12	13	74.558
#448	NR2F6	1	11	12	10.092
#449	SPDEF	1	10	11	513.047
#450	NFATC4	1	12	13	162.067
#451	NFATC1	1	15	16	732.542
#452	ESRRG	1	12	13	16.288
#453	ZXDC	1	13	14	789.912
#454	ZFHX4	1	12	13	27.129
#455	TP63	1	17	18	1978.986
#456	TP73	1	16	17	200.367
#457	FOXN4	1	11	12	95.267
#458	POU3F4	1	15	16	44.738
#459	FOXP3	1	10	11	386.767
#460	RXRB	1	14	15	209.615
#461	ZNF639	1	10	11	16.456
#462	ZNF85	1	11	12	1365.964
#463	PITX2	1	12	13	11.636
#464	NKX2-8	1	14	15	27.564
#465	PGBD1	1	13	14	876.911
#466	HOXA10	1	14	15	87.18
#467	FOXO6	1	13	14	8.772
#468	PAX6	1	11	12	7.461
#469	NR4A3	1	12	13	2418.269
#470	NR1I3	1	16	17	90.148
#471	SCML1	0	13	13	0
#472	FOXQ1	0	14	14	0
#473	FLI1	0	8	8	0
#474	PAX3	0	10	10	0
#475	ISL1	0	19	19	0
#476	ELF5	0	16	16	0
#477	FOXA2	0	17	17	0
#478	SCAND3	0	12	12	0
#479	KCNH8	0	16	16	0
#480	ZBTB38	0	14	14	0
#481	LEF1	0	13	13	0
#482	ZNF167	0	13	13	0
#483	TRIM29	0	14	14	0
#484	SOX5	0	18	18	0
#485	PAX7	0	16	16	0
#486	MYF6	0	17	17	0
#487	AR	0	12	12	0
#488	MTA2	0	9	9	0
#489	ZNF207	0	11	11	0
#490	ISX	0	18	18	0
#491	ZNF396	0	14	14	0
#492	TFCP2L1	0	13	13	0
#493	HOXC5	0	9	9	0
#494	ZNF446	0	12	12	0
#495	TADA3	0	20	20	0
#496	HSF5	0	16	16	0
#497	FOXJ1	0	21	21	0
#498	ZIC2	0	8	8	0
#499	OTX1	0	13	13	0
#500	ZNF449	0	17	17	0