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Hub Rank	Node	Children	Parents	Degree	Betweenness
#1	MESP2	45	3	48	414.028
#2	NFATC1	41	4	45	1576.907
#3	ELF3	34	2	36	60.143
#4	CBFA2T2	34	1	35	30.86
#5	ZNF444	34	9	43	1747.327
#6	HCFC1	32	13	45	2355.807
#7	MAFF	32	1	33	1484.055
#8	CEBPE	31	9	40	1515.09
#9	RORC	30	5	35	1111.085
#10	DDIT3	30	3	33	126.277
#11	POU6F1	29	7	36	3023.895
#12	LHX6	28	11	39	2191.253
#13	HLF	28	7	35	463.989
#14	TFEB	28	6	34	871.276
#15	TBX5	27	8	35	1215.925
#16	LMX1B	26	4	30	181.166
#17	ATF5	25	12	37	1164.446
#18	ZNF446	25	10	35	2076.16
#19	TADA2A	25	8	33	815.209
#20	ZNF85	24	9	33	1569.401
#21	MEIS3	24	13	37	1297.044
#22	FOS	24	4	28	734.489
#23	KDM5A	23	8	31	1687.607
#24	ENO1	23	3	26	61.327
#25	MESP1	23	13	36	1677.363
#26	BCL3	23	6	29	1091.077
#27	ZSCAN1	23	10	33	1684.089
#28	HEY1	22	7	29	1066.385
#29	VAV1	22	11	33	1714.491
#30	NKX6-2	22	11	33	1146.55
#31	C5orf41	22	9	31	1532.881
#32	PRDM1	21	11	32	2838.58
#33	JUN	21	15	36	1951.867
#34	TP73	21	4	25	161.222
#35	HR	20	14	34	1335.171
#36	HMX1	20	8	28	1799.108
#37	POU4F3	20	5	25	796.864
#38	TAF4	20	9	29	1387.138
#39	RELA	20	9	29	1590.739
#40	NOTCH1	20	10	30	917.951
#41	PBX4	20	8	28	1418.791
#42	LZTS1	20	10	30	786.98
#43	MLX	20	11	31	1246.191
#44	ZNF174	19	14	33	3153.593
#45	SIX6	19	12	31	2258.659
#46	CRX	19	13	32	1890.377
#47	RB1	19	9	28	1533.574
#48	C12orf28	19	6	25	782.709
#49	TAL1	19	12	31	1726.423
#50	TBX19	19	10	29	1269.21
#51	GSX1	18	12	30	2497.879
#52	GLI3	18	13	31	1795.837
#53	RERE	18	8	26	726.861
#54	FOXO3	18	14	32	1583.99
#55	SOX13	18	8	26	1150.228
#56	TRIM22	18	3	21	73.777
#57	ZNF41	18	12	30	1353.409
#58	TCF3	18	10	28	1714.428
#59	ERF	18	13	31	1263.375
#60	POU3F3	18	12	30	1144.295
#61	POU2F1	18	6	24	1075.384
#62	ZNF219	18	15	33	1194.915
#63	RXRG	18	10	28	690.477
#64	HOXC9	18	15	33	1894.844
#65	MXD1	18	12	30	1251.513
#66	MYCN	17	11	28	1835.099
#67	ZXDC	17	7	24	351.39
#68	KLF2	17	17	34	1604.758
#69	TFDP2	17	14	31	1364.845
#70	PPARD	17	12	29	1199.414
#71	DLX4	17	11	28	1411.551
#72	ZSCAN2	17	11	28	1135.463
#73	HOXA1	17	16	33	1834.759
#74	ZNF167	17	11	28	1124.465
#75	SOX10	17	8	25	648.529
#76	TBX21	17	13	30	1724.573
#77	NKX6-1	17	8	25	858.54
#78	SMAD6	17	12	29	1340.307
#79	SIX1	17	10	27	1145.177
#80	NKX2-3	17	7	24	870.967
#81	NPAS1	17	12	29	2176.062
#82	POU3F2	17	13	30	1868.738
#83	ELK4	16	13	29	1646.639
#84	ZSCAN18	16	12	28	1254.009
#85	TGIF2LY	16	7	23	802.415
#86	HOXA9	16	9	25	1259.123
#87	RELB	16	12	28	1383.524
#88	RUNX1	16	19	35	2129.222
#89	FOXO4	16	11	27	749.343
#90	LHX4	16	8	24	1042.683
#91	POU1F1	16	9	25	957.841
#92	ATF7	16	13	29	1874.524
#93	HOXD9	16	9	25	624.667
#94	BNC1	16	13	29	1151.154
#95	IRF5	16	8	24	806.686
#96	TFDP3	16	8	24	1066.167
#97	RBPJ	16	11	27	909.531
#98	CREB5	16	9	25	784.681
#99	NR4A1	16	14	30	1003.865
#100	HSF4	16	11	27	1141.866
#101	DBP	16	10	26	572.249
#102	SNAPC5	16	10	26	1159.259
#103	ZNF175	16	6	22	541.755
#104	EGR3	15	8	23	912.389
#105	TRERF1	15	12	27	874.58
#106	PAX5	15	10	25	906.308
#107	WNT5A	15	12	27	1637.776
#108	ZNF202	15	13	28	849.711
#109	NFE2L2	15	13	28	1563.417
#110	ZSCAN20	15	14	29	1832.716
#111	ZSCAN4	15	12	27	1420.684
#112	SEBOX	15	9	24	1615.824
#113	SIX5	15	12	27	1020.629
#114	SMAD3	15	10	25	783.35
#115	HOXC12	15	15	30	1379.523
#116	GATAD2B	15	6	21	867.938
#117	CEBPD	15	14	29	1458.308
#118	PHTF1	15	10	25	1110.031
#119	HOXD10	15	8	23	819.918
#120	MECOM	15	10	25	1248.893
#121	CBFA2T3	15	10	25	1229.74
#122	FOXP1	15	11	26	1119.685
#123	ALX3	15	10	25	927.361
#124	GSC2	15	13	28	1277.49
#125	TGIF1	15	9	24	1406.731
#126	PGR	15	6	21	350.05
#127	TEF	14	12	26	964.23
#128	MLL	14	11	25	562.804
#129	SIM1	14	9	23	879.566
#130	CITED1	14	10	24	944.111
#131	NR1I2	14	12	26	1855.903
#132	TEAD2	14	10	24	1317.105
#133	RORA	14	13	27	1242.431
#134	ZNF135	14	10	24	1313.644
#135	CREB3L1	14	12	26	830.097
#136	CDKN2A	14	10	24	1133.126
#137	STAT4	14	11	25	1007.531
#138	KLF12	14	12	26	1337.865
#139	TULP4	14	10	24	989.919
#140	PURA	14	16	30	1609.903
#141	RUNX1T1	14	10	24	1823.592
#142	NPAS2	14	17	31	1320.642
#143	HOXD3	14	11	25	1015.55
#144	LHX1	14	11	25	1058.828
#145	RAX2	14	7	21	607.707
#146	ZNF19	14	9	23	1151.559
#147	STAT5B	14	8	22	960.11
#148	ETV5	14	14	28	1758.383
#149	PDX1	14	8	22	880.013
#150	CREBBP	14	13	27	1251.98
#151	RXRB	14	10	24	1435.233
#152	L3MBTL4	14	11	25	1299.634
#153	ZNF117	14	12	26	1293.409
#154	DMRT2	14	14	28	1803.803
#155	CBL	14	16	30	1563.274
#156	HDX	13	17	30	2052.408
#157	NR0B1	13	14	27	1256.863
#158	ZNF193	13	10	23	477.605
#159	SOX15	13	11	24	1411.003
#160	MZF1	13	5	18	612.201
#161	KLF9	13	11	24	701.483
#162	HEYL	13	8	21	456.051
#163	SNAI2	13	8	21	768.792
#164	SP140	13	13	26	861.775
#165	SMAD9	13	13	26	1599.658
#166	DLX3	13	7	20	632.992
#167	HOXA2	13	12	25	1580.487
#168	ATF6B	13	8	21	962.914
#169	PLAG1	13	6	19	540.481
#170	HOXB8	13	9	22	607.675
#171	IKZF3	13	14	27	1333.09
#172	HOXC5	13	12	25	1329.665
#173	PHOX2B	13	13	26	786.821
#174	AFF4	13	15	28	1302.176
#175	NFYA	13	11	24	1054.893
#176	NFATC2	13	15	28	1086.228
#177	TAF1B	13	8	21	825.058
#178	BCL6	13	10	23	982.382
#179	ZNF483	13	8	21	1938.639
#180	NR6A1	13	11	24	1241.416
#181	ONECUT2	13	12	25	1329.006
#182	PAX4	13	7	20	773.531
#183	POU4F2	13	14	27	1181.242
#184	TBX2	13	14	27	988.732
#185	SRY	13	7	20	974.777
#186	TBX6	13	7	20	720.835
#187	HNF4G	13	9	22	615.947
#188	RARB	13	14	27	1047.441
#189	NR2E3	12	13	25	1286.358
#190	ZNF3	12	6	18	452.687
#191	RUNX3	12	12	24	860.366
#192	TCF4	12	17	29	1298.776
#193	ARNT	12	12	24	1340.964
#194	GRHL3	12	9	21	706.787
#195	BLZF1	12	8	20	1148.93
#196	TFAP2B	12	15	27	1135.058
#197	HIF3A	12	14	26	1338.508
#198	ZNF92	12	11	23	1114.009
#199	GAS7	12	14	26	1415.195
#200	NR1I3	12	12	24	790.221
#201	KLF15	12	12	24	902.572
#202	ZNF197	12	7	19	603.208
#203	MMP14	12	16	28	1817.44
#204	DMRT1	12	10	22	769.845
#205	WT1	12	9	21	414.737
#206	NFE2L3	12	10	22	917.113
#207	LHX9	12	12	24	962.856
#208	HOXB2	12	7	19	863.047
#209	TCF15	12	9	21	723.875
#210	HEY2	12	11	23	904.243
#211	NFIX	12	12	24	1365.912
#212	TSHZ2	12	14	26	1129.811
#213	MYT1L	12	13	25	1526.66
#214	HOXD4	12	14	26	2071.402
#215	FOXJ2	12	10	22	941.21
#216	TBX20	12	15	27	1758.418
#217	BATF2	12	10	22	1012.111
#218	BHLHE41	12	13	25	1188.617
#219	NKX2-1	12	13	25	1470.003
#220	HOXD13	12	15	27	1301.898
#221	ZNF449	11	11	22	1048.907
#222	IRF8	11	11	22	1253.561
#223	ZHX3	11	15	26	1408.551
#224	ZNF207	11	9	20	744.994
#225	GATA5	11	9	20	744.336
#226	CLOCK	11	5	16	579.052
#227	FOXP3	11	10	21	763.778
#228	NCOR1	11	9	20	854.979
#229	TFE3	11	11	22	1026.935
#230	SOX5	11	14	25	1163.242
#231	NEUROD1	11	10	21	786.695
#232	POU3F4	11	15	26	1193.561
#233	ZNF628	11	13	24	1060.946
#234	SNAI3	11	17	28	1519.414
#235	PURB	11	9	20	841.594
#236	TLX2	11	9	20	779.798
#237	NR2F2	11	16	27	1369.59
#238	FOXG1	11	9	20	783.387
#239	FOXE1	11	11	22	1181.705
#240	POU2F2	11	14	25	1084.261
#241	DMBX1	11	11	22	1062.87
#242	TBX3	11	10	21	1280.331
#243	TCF21	11	12	23	1393.221
#244	SOX6	11	15	26	1610.403
#245	LMO4	11	6	17	327.63
#246	KLF17	11	13	24	1118.198
#247	FOXI1	11	9	20	752.241
#248	ATF2	11	8	19	807.061
#249	ZNF131	11	15	26	1671.129
#250	SMAD4	11	13	24	899.929
#251	PPBPL2	11	7	18	560.924
#252	EMX1	11	11	22	761.821
#253	ZNF80	11	12	23	1144.123
#254	SOX2	11	12	23	1313.728
#255	ZSCAN5A	11	10	21	588.51
#256	MYF5	11	13	24	1240.646
#257	NKX2-5	11	12	23	1156.61
#258	EPAS1	10	7	17	637.138
#259	MYNN	10	14	24	1095.69
#260	VSX1	10	11	21	628.318
#261	ZNF90	10	12	22	1075.163
#262	ZHX2	10	14	24	814.587
#263	NFIB	10	17	27	2012.015
#264	CREB3L3	10	12	22	709.431
#265	ARNTL2	10	13	23	1348.44
#266	BRD8	10	12	22	1475.71
#267	ZSCAN23	10	11	21	753.621
#268	HOXA11	10	17	27	1001.177
#269	CREBZF	10	15	25	1302.842
#270	HOPX	10	14	24	727.362
#271	ASCL1	10	14	24	959.695
#272	ESX1	10	14	24	1314.827
#273	FOXF1	10	10	20	972.499
#274	FOXB1	10	15	25	1257.113
#275	MEF2C	10	14	24	1264.016
#276	EN2	10	11	21	1311.697
#277	HNF1A	10	8	18	848.385
#278	POU5F2	10	10	20	1052.773
#279	GATA4	10	14	24	1435.233
#280	PCGF2	10	16	26	1047.145
#281	NRL	10	8	18	355.616
#282	EGR2	10	11	21	684.535
#283	PRRX1	10	15	25	797.786
#284	LASS5	10	13	23	1158.742
#285	VTN	10	16	26	1173.348
#286	TSC22D3	10	7	17	424.504
#287	ETS2	10	9	19	620.964
#288	ZSCAN12	10	15	25	1005.324
#289	NOBOX	10	7	17	465.796
#290	HOXB1	10	8	18	720.028
#291	LEF1	10	13	23	654.604
#292	ZNF639	10	12	22	854.389
#293	TFAP4	10	10	20	575.605
#294	SOX7	10	10	20	826.816
#295	HOXA3	10	11	21	531.422
#296	ASCL2	10	14	24	1002.756
#297	TLX1	10	13	23	1101.207
#298	ZNF500	10	8	18	478.646
#299	SNAPC4	10	15	25	833.653
#300	PEG3	10	9	19	963.959
#301	ALS2CR8	9	10	19	884.093
#302	CREB3L2	9	15	24	902.259
#303	MYF6	9	11	20	787.759
#304	FOXL1	9	13	22	874.37
#305	HMG20B	9	13	22	801.505
#306	SPIC	9	13	22	845.297
#307	ELF5	9	15	24	1001.391
#308	TFCP2L1	9	11	20	647.772
#309	TRIM29	9	13	22	1090.466
#310	OLIG2	9	7	16	384.125
#311	TADA3	9	13	22	797.143
#312	GCM1	9	8	17	845.51
#313	TBR1	9	11	20	916.301
#314	MYCL1	9	12	21	870.95
#315	SPDEF	9	12	21	530.81
#316	HESX1	9	12	21	822.837
#317	BACH1	9	14	23	777.4
#318	ARX	9	16	25	954.822
#319	PHOX2A	9	10	19	949.823
#320	ONECUT1	9	13	22	917.26
#321	JUND	9	12	21	835.527
#322	ETV1	9	11	20	986.453
#323	BACH2	9	10	19	732.248
#324	TCF7L2	9	11	20	831.438
#325	GBX2	9	14	23	850.086
#326	KDM5B	9	14	23	841.076
#327	PKNOX2	9	12	21	713.048
#328	NFE2	9	13	22	393.527
#329	RARG	9	13	22	942.758
#330	TBX1	9	15	24	1807.789
#331	VENTX	9	11	20	715.214
#332	ZNF397	9	11	20	605.665
#333	NFIA	9	14	23	820.424
#334	GATA6	9	13	22	908.083
#335	TCF12	9	14	23	1044.847
#336	KCNH8	9	14	23	931.172
#337	REST	9	11	20	1208.336
#338	ANKRD30A	9	15	24	969.484
#339	ZEB1	9	16	25	867.688
#340	NR1H4	9	17	26	1067.981
#341	ZNF215	9	14	23	1329.878
#342	ELK1	9	13	22	761.339
#343	HES6	9	12	21	833.193
#344	RCAN1	9	13	22	758.45
#345	FOXE3	9	10	19	1060.655
#346	NPAT	9	17	26	1222.781
#347	SLC26A3	9	12	21	1063.957
#348	PPARA	9	12	21	1102.445
#349	FOXR2	9	14	23	1493.187
#350	MLLT10	9	15	24	854.2
#351	NR5A1	9	9	18	562.778
#352	FLI1	8	16	24	1347.45
#353	ALX1	8	11	19	482.879
#354	TSC22D1	8	11	19	747.998
#355	HOXA13	8	11	19	651.713
#356	NFATC3	8	15	23	727.981
#357	NEUROG1	8	14	22	814.31
#358	RORB	8	12	20	850.029
#359	C2orf3	8	11	19	714.409
#360	PAX7	8	11	19	670.617
#361	NFATC4	8	13	21	494.357
#362	EVX1	8	10	18	578.841
#363	ZIC3	8	12	20	768.538
#364	OTX2	8	16	24	1610.803
#365	SIM2	8	9	17	1087.619
#366	FOXN4	8	13	21	1107.527
#367	IRF1	8	11	19	725.872
#368	PBX3	8	15	23	1104.214
#369	HES5	8	15	23	939.496
#370	ZNF70	8	11	19	803.489
#371	ZIC1	8	15	23	959.479
#372	HOXB13	8	10	18	567.983
#373	IRF4	8	15	23	950.729
#374	FOXA3	8	11	19	954.567
#375	MEIS2	8	14	22	683.09
#376	SOX11	8	15	23	1076.379
#377	EGR4	8	13	21	583.684
#378	IRX1	8	18	26	1219.886
#379	NFYC	8	13	21	708.729
#380	ZNF396	8	12	20	899.134
#381	SPIB	8	9	17	441.311
#382	NR2E1	8	16	24	989.557
#383	TP63	8	18	26	1017.89
#384	ZNF33B	8	14	22	948.473
#385	FOXC2	7	16	23	1008.561
#386	SIX4	7	13	20	626.21
#387	SATB1	7	17	24	798.893
#388	SP3	7	11	18	793.531
#389	PRDM2	7	15	22	764.496
#390	POU6F2	7	8	15	489.46
#391	ISX	7	12	19	1170.131
#392	CSRNP3	7	18	25	946.382
#393	CTBP1	7	11	18	607.271
#394	ZNF287	7	11	18	493.08
#395	NEUROD2	7	12	19	1041.696
#396	SMAD1	7	12	19	932.561
#397	ETV7	7	13	20	390.564
#398	NANOGNB	7	16	23	658.32
#399	ZFP36L1	7	13	20	533.403
#400	HIRA	7	13	20	784.879
#401	ZNF277	7	16	23	776.428
#402	GATAD1	7	14	21	763.236
#403	ST18	7	11	18	496.113
#404	ZNF154	7	11	18	517.184
#405	HES1	7	12	19	837.661
#406	HIC1	7	14	21	867.095
#407	SOX21	7	12	19	782.89
#408	TFEC	7	16	23	993.469
#409	ZNF157	7	12	19	667.658
#410	RUNX2	7	12	19	562.861
#411	PAX3	7	15	22	711.663
#412	MEF2D	7	14	21	606.483
#413	FOXD1	7	16	23	757.909
#414	ERG	7	15	22	858.556
#415	SIX3	7	15	22	979.353
#416	TSHZ3	7	14	21	792.961
#417	FOXK2	7	15	22	519.733
#418	GATAD2A	7	14	21	673.856
#419	MEOX2	7	7	14	278.584
#420	GATA3	6	8	14	314.2
#421	HMGA2	6	17	23	749.68
#422	FOXS1	6	8	14	459.107
#423	EN1	6	13	19	790.699
#424	BCL11B	6	13	19	644.149
#425	TCF20	6	14	20	650.019
#426	NR4A3	6	11	17	566.636
#427	ZNF81	6	10	16	447.621
#428	IRX2	6	10	16	441.756
#429	PLSCR1	6	19	25	1030.167
#430	TFAP2D	6	10	16	530.5
#431	FOXP4	6	10	16	515.403
#432	HOXC8	6	16	22	769.084
#433	HMGB2	6	11	17	527.976
#434	SIN3A	6	14	20	782.328
#435	ZNF93	6	11	17	399.731
#436	CREM	6	12	18	638.779
#437	MSX2	6	13	19	760.683
#438	MIXL1	6	15	21	787.159
#439	ZNF71	6	8	14	439.543
#440	DLX1	6	14	20	623.287
#441	TSC22D2	6	11	17	528.056
#442	HNF4A	6	15	21	1015.201
#443	SOX18	6	9	15	467.685
#444	FOXH1	6	15	21	613.173
#445	IRX4	6	10	16	306.138
#446	EBF1	6	18	24	864.567
#447	FOXN3	6	11	17	477.85
#448	THRA	5	15	20	819.104
#449	MKX	5	15	20	590.558
#450	ATF3	5	10	15	466.31
#451	HNRNPAB	5	16	21	483.402
#452	ZFHX3	5	15	20	695.889
#453	SLC2A4RG	5	15	20	569.771
#454	NANOG	5	12	17	732.718
#455	CEBPA	5	12	17	520.141
#456	IKZF1	5	19	24	1383.657
#457	TCF7	5	11	16	625.171
#458	GATA1	5	13	18	533.438
#459	SCAND2	5	11	16	238.303
#460	ALX4	5	11	16	639.104
#461	ATOH1	5	16	21	644.808
#462	TFAP2A	5	14	19	547.633
#463	ESRRB	5	16	21	997.995
#464	HOXD1	5	15	20	671.188
#465	ZFHX4	5	13	18	846.156
#466	LMX1A	5	11	16	374.008
#467	FOXA1	5	16	21	643.826
#468	RARA	4	19	23	448.478
#469	GLI2	4	15	19	473.398
#470	POU3F1	4	17	21	492.696
#471	ZFP42	4	15	19	538.433
#472	FOXP2	4	15	19	316.513
#473	FOXK1	4	11	15	368.509
#474	FOXO1	4	18	22	416.972
#475	NR5A2	4	16	20	484.169
#476	SATB2	4	15	19	721.546
#477	OVOL1	4	15	19	452.854
#478	TBX22	4	15	19	553.974
#479	CUX2	4	12	16	387.354
#480	ESR2	4	16	20	606.278
#481	ZFPM2	4	16	20	661.742
#482	PROX1	4	12	16	385.701
#483	HSF5	4	13	17	404.085
#484	ZEB2	4	16	20	712.707
#485	MGA	4	11	15	320.268
#486	PTH	4	11	15	749.49
#487	SOX30	3	11	14	307.971
#488	MAF	3	13	16	310.773
#489	POU2F3	3	15	18	282.233
#490	MYT1	3	17	20	244.294
#491	NFKB2	3	14	17	293.095
#492	FOXA2	3	12	15	370.323
#493	FOXD3	3	11	14	376.85
#494	ZSCAN10	2	13	15	265.27
#495	ESR1	2	17	19	305.094
#496	ZNF24	2	13	15	239.651
#497	ZBTB38	2	15	17	276.501
#498	SOX1	2	18	20	291.739
#499	RBPJL	2	16	18	321.913
#500	LHX8	2	19	21	295.858