Hub Rank	Node	Children	Parents	Degree	Betweenness
#1	SNAI2	45	2	47	211.855
#2	NPAS2	43	3	46	495.955
#3	UHRF1	41	5	46	432.02
#4	TRERF1	40	11	51	3667.229
#5	TFCP2L1	39	6	45	1797.491
#6	HNF1B	38	8	46	2878.784
#7	HOXD10	37	7	44	324.596
#8	TCF7L1	37	4	41	474.051
#9	PEG3	37	10	47	862.833
#10	NR1H4	35	9	44	1834.708
#11	FUBP1	35	5	40	2262.541
#12	GLIS3	34	10	44	2020.897
#13	EBF1	32	9	41	1542.23
#14	EPAS1	32	13	45	2333.989
#15	BACH2	32	9	41	1122.635
#16	NR2F1	32	4	36	358.814
#17	E2F7	31	5	36	236.499
#18	MECOM	31	12	43	1753.607
#19	BCL11B	31	7	38	1358.566
#20	CREB5	30	7	37	1721.768
#21	SALL1	30	9	39	1051.283
#22	IRX3	30	9	39	1091.505
#23	HOXC9	30	8	38	894.132
#24	MEIS1	30	5	35	242.035
#25	ELF3	30	6	36	348.63
#26	GATA2	30	7	37	1017.403
#27	ERG	29	6	35	194.347
#28	FOXC2	28	9	37	522.654
#29	IKZF1	28	3	31	124.566
#30	PTTG1	28	5	33	209.459
#31	HOXD11	28	8	36	1112.595
#32	MEIS2	28	7	35	338.857
#33	NR3C2	27	9	36	522.275
#34	AHR	27	11	38	591.915
#35	LZTS1	27	5	32	213.432
#36	ARNT2	26	9	35	4476.844
#37	SIX1	26	8	34	411.949
#38	FOXD1	26	16	42	1165.849
#39	ESRRG	26	4	30	759.854
#40	DMRT2	26	7	33	1116.556
#41	PAX8	26	10	36	2745.49
#42	MSC	25	9	34	869.916
#43	TWIST1	25	9	34	575.699
#44	HOXA3	25	9	34	432.142
#45	HCLS1	24	4	28	265.503
#46	SIX4	24	11	35	3198.325
#47	TRIM22	24	11	35	1215.444
#48	PRRX1	24	9	33	1053.48
#49	MYCN	24	12	36	1378.543
#50	PRDM1	23	8	31	398.74
#51	VAV1	23	7	30	879.081
#52	NKX2-1	23	6	29	2187.154
#53	PPARG	23	12	35	6337.632
#54	ZIC1	23	7	30	1301.873
#55	HOXC13	23	6	29	439.445
#56	TFEC	22	8	30	1301.593
#57	NFE2L3	22	9	31	1328.859
#58	RORC	22	11	33	545.407
#59	RUNX3	22	4	26	955.052
#60	ZFPM2	22	10	32	1556.206
#61	FOXO6	21	12	33	638.123
#62	SIM1	21	17	38	4283.825
#63	AR	21	9	30	328.848
#64	HOXD1	20	12	32	3192.401
#65	LEF1	20	14	34	1188.184
#66	KLF4	20	11	31	613.116
#67	FOXM1	20	6	26	224.474
#68	FOXI1	20	7	27	499.255
#69	ZNF135	20	14	34	3971.693
#70	PKNOX2	19	13	32	2439.795
#71	TCF21	19	9	28	662.003
#72	ZNF167	19	11	30	3594.371
#73	KLF5	19	12	31	1173.254
#74	SOX4	19	11	30	567.525
#75	SOX6	19	11	30	1408.245
#76	GATAD2B	19	13	32	1942.841
#77	TCF12	19	9	28	788.34
#78	PLAG1	18	13	31	1756.569
#79	EOMES	18	8	26	589.018
#80	HOXA7	18	3	21	428.167
#81	TWIST2	18	12	30	2240.202
#82	FOXC1	18	13	31	364.234
#83	CREB3L1	18	15	33	771.046
#84	TBX3	18	15	33	1463.84
#85	FOXQ1	18	14	32	2180.823
#86	TCF4	18	7	25	392.731
#87	POU2F2	18	7	25	515.675
#88	SOX17	18	8	26	371.759
#89	TEAD4	18	9	27	887.079
#90	ETV1	17	16	33	3391.761
#91	KLF15	17	11	28	648.043
#92	AFF4	17	12	29	2458.753
#93	C11orf9	17	9	26	371.615
#94	EN1	17	12	29	3577.822
#95	FOXF1	17	14	31	942.035
#96	NR0B1	17	20	37	4319.244
#97	BHLHE41	17	10	27	556.843
#98	MEF2C	17	8	25	734.65
#99	TSHZ3	17	12	29	1079.979
#100	HOXA10	17	1	18	674.487
#101	THRB	17	18	35	2523.989
#102	HMGA2	17	10	27	2181.381
#103	MEOX1	16	12	28	490.326
#104	ETV4	16	12	28	875.148
#105	ISL1	16	11	27	423.171
#106	HOXB6	16	10	26	668.728
#107	ETV6	16	9	25	807.101
#108	IRX1	16	7	23	1415.931
#109	GRHL2	16	8	24	689.309
#110	ZNF197	16	12	28	2557.998
#111	ZIC3	16	12	28	1430.147
#112	GLI2	16	12	28	1331.863
#113	HOXC11	16	9	25	713.044
#114	FOXF2	15	13	28	2312.783
#115	HIC1	15	12	27	557.845
#116	KLF6	15	11	26	1172.423
#117	HOXA13	15	11	26	2656.535
#118	HEY1	15	16	31	659.636
#119	ELF5	15	7	22	1006.097
#120	ARNTL2	15	13	28	1755.392
#121	ATF5	15	16	31	2607.745
#122	CUX2	15	14	29	1341.251
#123	GLI3	15	6	21	1104.151
#124	FOXL1	15	10	25	1217.073
#125	MAF	15	14	29	1527.085
#126	RARB	15	16	31	1557.55
#127	ZFHX4	15	12	27	1579.204
#128	VDR	15	11	26	1515.112
#129	ETV7	15	14	29	3719.79
#130	CITED1	14	9	23	679.117
#131	ZNF238	14	12	26	1433.172
#132	TBX1	14	14	28	1931.688
#133	GCM1	14	13	27	1173.682
#134	ZNF236	14	5	19	580.852
#135	POU5F1B	14	7	21	225.404
#136	HNF4G	14	14	28	1824.816
#137	NFIX	14	13	27	1117.602
#138	SATB2	14	13	27	895.928
#139	TGIF1	14	16	30	1053.592
#140	EGR4	14	12	26	1761.927
#141	BARX1	14	13	27	3419.992
#142	NFATC2	14	11	25	375.396
#143	NR5A1	14	14	28	1682.841
#144	HEYL	14	8	22	508.861
#145	CREBBP	14	13	27	2214.058
#146	AEBP1	14	13	27	1184.046
#147	PRRX2	14	13	27	1552.98
#148	STAT1	14	15	29	799.136
#149	IRX4	14	10	24	1431.421
#150	CEBPA	14	16	30	1327.703
#151	PITX2	14	12	26	458.171
#152	ETS1	14	18	32	2457.091
#153	HLF	14	17	31	1052.395
#154	TBX2	14	14	28	942.524
#155	SOX9	14	14	28	904.727
#156	HOXB8	13	11	24	1559.957
#157	NFIB	13	16	29	1073.754
#158	BHLHE40	13	10	23	357.593
#159	EHF	13	13	26	2350.995
#160	RFXAP	13	11	24	806.458
#161	ZNF41	13	12	25	1172.451
#162	PGR	13	20	33	3843.687
#163	HOXA1	13	9	22	257.617
#164	ONECUT2	13	12	25	1294.981
#165	SIM2	13	14	27	1403.482
#166	SMAD9	13	16	29	586.469
#167	TSHZ2	13	15	28	1996.367
#168	PITX1	13	19	32	2148.041
#169	KLF12	13	16	29	1056.299
#170	SPIB	13	14	27	1948.355
#171	HOXA5	13	9	22	415.556
#172	ZNF287	13	12	25	2646.782
#173	ZIC2	13	8	21	825.986
#174	EGR1	13	7	20	785.476
#175	ZEB2	13	12	25	2372.303
#176	MYC	12	10	22	791.841
#177	TEAD2	12	14	26	1670.532
#178	DLX2	12	12	24	2128.143
#179	HCFC1	12	14	26	1361.535
#180	EMX1	12	15	27	567.817
#181	TCF7	12	11	23	859.778
#182	HOXB13	12	10	22	1990.355
#183	EN2	12	11	23	881.537
#184	ZNF202	12	14	26	1912.56
#185	SOX18	12	12	24	1099.282
#186	PKNOX1	12	13	25	1511.472
#187	FOSL1	12	14	26	1170.852
#188	PGBD1	12	12	24	2003.632
#189	NR4A1	12	13	25	697.915
#190	IRF6	12	17	29	1559.221
#191	TFDP1	12	11	23	1450.93
#192	EGR2	12	14	26	1647.405
#193	MLLT10	12	11	23	1087.017
#194	TFAP2A	12	9	21	1217.496
#195	SOX11	12	14	26	542.914
#196	RUNX1T1	12	17	29	789.721
#197	FOXA2	12	14	26	1336.055
#198	FOS	12	12	24	516.539
#199	MNX1	12	9	21	413.965
#200	PAX3	12	14	26	1712.162
#201	IRX5	12	15	27	375.645
#202	MLL	12	13	25	2317.757
#203	ZNF643	12	16	28	4605.579
#204	HES5	12	11	23	832.204
#205	HOXA11	12	17	29	1056.788
#206	HESX1	11	12	23	1068.005
#207	SOX2	11	9	20	360.732
#208	GATA6	11	16	27	1150.919
#209	FOXA1	11	14	25	2079.349
#210	TRIM29	11	11	22	1052.595
#211	CSRNP3	11	21	32	939.272
#212	POU2F1	11	10	21	1237.943
#213	CREB3L3	11	17	28	1678.381
#214	POU4F1	11	9	20	1949.432
#215	HOXD4	11	10	21	1965.202
#216	IRF1	11	19	30	607.393
#217	CEBPD	11	15	26	749.416
#218	MYNN	11	14	25	1903.007
#219	TBX15	11	16	27	1265.225
#220	ASCL2	11	15	26	1164.772
#221	PURB	11	12	23	841.828
#222	LHX1	11	13	24	831.217
#223	CDKN2A	11	11	22	659.408
#224	SOX7	11	8	19	334.884
#225	ZNF496	11	13	24	943.23
#226	ZHX2	11	14	25	718.16
#227	HSF4	11	12	23	899.995
#228	ZNF192	11	12	23	1319.838
#229	ZNF24	11	12	23	1270.231
#230	ZNF446	11	9	20	597.488
#231	ERF	11	9	20	665.207
#232	CLOCK	11	11	22	1028.814
#233	LMO4	11	15	26	2137.472
#234	SNAI3	10	14	24	1273.725
#235	TFAP2B	10	10	20	685.749
#236	HOXA9	10	14	24	655.856
#237	FOXG1	10	12	22	1493.062
#238	NR5A2	10	14	24	594.365
#239	ZNF93	10	9	19	996.251
#240	HIRA	10	10	20	1117.904
#241	NR2F6	10	13	23	1110.323
#242	ZSCAN2	10	9	19	1038.672
#243	LHX9	10	12	22	1162.379
#244	ETS2	10	18	28	745.404
#245	PAX4	10	11	21	1352.014
#246	GATA3	10	14	24	582.685
#247	KDM5B	10	10	20	2564.018
#248	HNF4A	10	13	23	378.829
#249	LMX1A	10	10	20	946.448
#250	LHX2	10	10	20	1393.438
#251	TCF3	10	14	24	1271.855
#252	STAT5B	10	17	27	1778.262
#253	SMAD3	10	8	18	690.203
#254	WNT5A	10	15	25	519.622
#255	MYT1L	10	16	26	1102.313
#256	MYF5	10	12	22	755.582
#257	ISL2	10	11	21	699.695
#258	GATA4	10	9	19	745.127
#259	ZFHX3	10	14	24	1334.808
#260	NFIA	10	11	21	966.394
#261	RORA	10	10	20	1130.837
#262	HIF3A	10	13	23	772.971
#263	GAS7	10	14	24	1435.054
#264	HOXD3	10	14	24	1143.956
#265	RARG	10	12	22	2435.204
#266	FOSL2	10	14	24	1257.203
#267	TADA3	10	6	16	1114.624
#268	ASCL1	10	14	24	3609.226
#269	MYF6	10	11	21	1242.213
#270	TFE3	10	18	28	922.206
#271	ZNF3	10	14	24	1836.181
#272	ZEB1	9	13	22	798.769
#273	MYBL2	9	11	20	506.436
#274	ESRRB	9	13	22	884.241
#275	WT1	9	18	27	502.332
#276	ZSCAN20	9	11	20	786.019
#277	MSX2	9	19	28	1382.599
#278	MMP14	9	14	23	1926.082
#279	DLX3	9	12	21	1225.197
#280	TAF13	9	16	25	1652.038
#281	DMBX1	9	12	21	1195.033
#282	NR4A2	9	11	20	768.11
#283	FOSB	9	9	18	421.183
#284	HES6	9	15	24	653.871
#285	POU3F3	9	13	22	694.069
#286	NKX3-2	9	11	20	1259.063
#287	NFATC4	9	10	19	926.399
#288	NR4A3	9	16	25	797.703
#289	HOXA2	9	7	16	172.898
#290	MKX	9	16	25	914.053
#291	IRF4	9	13	22	1057.208
#292	TBR1	9	16	25	1319.625
#293	TAL1	9	13	22	424.56
#294	ZSCAN23	9	13	22	1218.585
#295	PPARA	9	12	21	885.61
#296	T	9	12	21	721.907
#297	LHX6	9	15	24	863.827
#298	TP63	9	16	25	2116.719
#299	ZNF165	9	14	23	660.281
#300	SCAND3	9	15	24	650.781
#301	TFAP2C	9	13	22	643.028
#302	ZSCAN12	9	11	20	1171.441
#303	HOXA4	9	14	23	651.553
#304	FOXP2	9	16	25	870.903
#305	NR2E1	9	14	23	2091.404
#306	FOXD4	8	16	24	1107.782
#307	NR1I3	8	11	19	598.001
#308	ZNF174	8	13	21	735.5
#309	E2F8	8	14	22	372.156
#310	SOX8	8	17	25	792.366
#311	POU2F3	8	18	26	1741.754
#312	STRN3	8	17	25	2077.044
#313	HSF5	8	17	25	1314.617
#314	SP4	8	11	19	848.389
#315	SPI1	8	10	18	174.375
#316	ALX1	8	13	21	806.822
#317	SIN3A	8	10	18	628.671
#318	TGIF2LY	8	9	17	1185.857
#319	BCL3	8	14	22	1060.411
#320	NRL	8	10	18	910.92
#321	RXRG	8	9	17	1100.671
#322	NANOGNB	8	16	24	1716.68
#323	HOXD13	8	13	21	933.822
#324	POU3F4	8	12	20	1158.301
#325	PAX7	8	10	18	1327.833
#326	SCAND2	8	16	24	1264.847
#327	DLX6	8	12	20	1218.663
#328	OTX2	8	14	22	715.961
#329	FOXA3	8	14	22	2360.92
#330	ATOH1	8	11	19	916.456
#331	SP140	8	16	24	1093.477
#332	POU1F1	8	14	22	773.21
#333	POU5F2	8	18	26	1925.241
#334	LHX4	8	11	19	1910.266
#335	FOXL2	8	14	22	2219.428
#336	ARNT	8	14	22	2864.21
#337	RCOR2	8	13	21	445.69
#338	SOLH	8	14	22	1646.901
#339	FOXD3	8	15	23	2627.853
#340	NKX6-1	8	13	21	1152.131
#341	TBX22	8	10	18	717.224
#342	NOBOX	8	15	23	878.052
#343	ZNF500	8	14	22	1380.939
#344	ATF6B	8	12	20	1285.796
#345	ZNF639	8	8	16	786.644
#346	ZNF85	8	15	23	2138.698
#347	ZFP42	8	16	24	1598.589
#348	ZXDC	8	11	19	972.283
#349	ZNF207	7	8	15	551.563
#350	RFX3	7	13	20	851.762
#351	IRX2	7	8	15	201.317
#352	THRA	7	15	22	683.551
#353	BNC1	7	15	22	763.332
#354	ZSCAN1	7	9	16	551.569
#355	SIX2	7	16	23	346.419
#356	DLX1	7	15	22	749.387
#357	PAX6	7	14	21	1147.437
#358	FOXR2	7	17	24	1099.82
#359	SMAD4	7	14	21	1030.489
#360	MITF	7	18	25	2691.328
#361	DMRT1	7	10	17	664.288
#362	NCOR1	7	10	17	764.567
#363	PROX1	7	11	18	1366.035
#364	SIX6	7	14	21	616.774
#365	SOX13	7	16	23	889.239
#366	GATAD1	7	13	20	929.766
#367	FOXO3	7	10	17	577.648
#368	ZNF397	7	15	22	678.765
#369	SMAD6	7	12	19	626.443
#370	FLI1	7	13	20	957.927
#371	ALS2CR8	7	8	15	492.108
#372	ZNF157	7	12	19	1280.076
#373	ESR2	7	17	24	1178.164
#374	NFKB2	7	12	19	835.299
#375	SMAD2	7	15	22	1634.81
#376	FOXD2	7	12	19	657.643
#377	KLF16	7	13	20	801.694
#378	CREM	7	10	17	1013.812
#379	ESR1	7	11	18	1462.806
#380	VTN	7	16	23	1302.517
#381	POU4F3	7	12	19	443.461
#382	LHX8	7	14	21	633.255
#383	PHOX2B	7	14	21	976.093
#384	OVOL1	7	14	21	680.143
#385	TULP4	7	11	18	960.745
#386	MYCL1	7	13	20	1072.285
#387	NFE2	7	14	21	381.054
#388	TBX20	7	14	21	1374.581
#389	NEUROD2	7	11	18	740.167
#390	POU3F2	7	14	21	733.335
#391	ELK4	7	14	21	895.076
#392	TLX2	7	10	17	451.975
#393	RARA	7	13	20	2677.507
#394	TEF	7	18	25	1118.74
#395	FOXP1	6	15	21	589.852
#396	BRD8	6	13	19	633.765
#397	ATF2	6	15	21	1241.202
#398	NFYA	6	14	20	913.251
#399	ZNF483	6	17	23	864.299
#400	RUNX2	6	17	23	944.475
#401	PURA	6	12	18	814.763
#402	ZKSCAN3	6	15	21	687.48
#403	ZNF396	6	14	20	745.94
#404	ZSCAN4	6	17	23	547.541
#405	PBX1	6	18	24	770.936
#406	NR6A1	6	10	16	655.982
#407	MLXIPL	6	11	17	314.041
#408	SOX5	6	16	22	846.016
#409	YY1	6	12	18	714.553
#410	PRDM2	6	10	16	550.463
#411	ATF3	6	10	16	372.818
#412	GSX2	6	17	23	858.875
#413	GBX2	6	12	18	364.78
#414	GRHL3	6	12	18	445.161
#415	REST	6	9	15	635.511
#416	MGA	6	11	17	977.608
#417	ZNF71	6	12	18	703.555
#418	GATA5	6	13	19	1604.815
#419	PPARD	6	14	20	618.482
#420	KLF9	6	14	20	937.029
#421	KLF17	6	13	19	1028.035
#422	TSC22D2	6	15	21	1987.73
#423	HMG20B	6	5	11	558.449
#424	PLSCR1	6	20	26	2403.725
#425	TP73	6	15	21	752.935
#426	MIXL1	6	15	21	590.073
#427	E2F2	6	16	22	893.488
#428	ZNF75D	6	10	16	598.097
#429	NKX2-8	6	12	18	500.473
#430	RUNX1	6	17	23	921.103
#431	HEY2	6	10	16	320.396
#432	ISX	5	16	21	1525.995
#433	ZNF444	5	12	17	457.273
#434	CTBP1	5	12	17	632.988
#435	ONECUT1	5	16	21	587.646
#436	DLX4	5	11	16	1135.31
#437	C2orf3	5	15	20	689.181
#438	TLX3	5	13	18	829.46
#439	IRF5	5	12	17	350.222
#440	FOXN4	5	9	14	344.281
#441	GSC2	5	8	13	349.726
#442	POU6F2	5	13	18	464.5
#443	ZNF90	5	14	19	676.258
#444	FOXJ1	5	11	16	591.249
#445	KCNH8	5	11	16	858.62
#446	POU4F2	5	15	20	759.44
#447	NANOG	5	18	23	786.154
#448	ARX	5	19	24	4309.983
#449	ESX1	5	10	15	452.463
#450	NKX6-2	5	15	20	519.645
#451	MEOX2	5	16	21	187.28
#452	TBX5	5	14	19	1211.97
#453	NR1I2	5	13	18	284.805
#454	NPAS1	5	13	18	1214.923
#455	NEUROD1	5	13	18	691.833
#456	NR2E3	5	16	21	1047.358
#457	SPIC	5	18	23	852.443
#458	C12orf28	5	11	16	348.582
#459	ZNF92	5	15	20	1231.082
#460	NPAT	5	14	19	627.695
#461	SLC26A3	5	13	18	1065.294
#462	JUND	5	14	19	513.102
#463	NKX2-3	5	11	16	610.566
#464	ATF7	5	13	18	1514.344
#465	VSX1	5	16	21	1119.056
#466	ZNF80	4	11	15	468.732
#467	MEIS3	4	12	16	228.29
#468	HOPX	4	11	15	657.214
#469	RORB	4	16	20	551.91
#470	AHCTF1	4	18	22	1113.991
#471	ST18	4	15	19	764.515
#472	NFAT5	4	18	22	163.471
#473	SOX1	4	12	16	1009.804
#474	PDX1	4	15	19	883.243
#475	ZNF81	4	9	13	348.775
#476	ZNF175	4	12	16	592.02
#477	ALX3	4	14	18	294.954
#478	OLIG2	4	15	19	607.901
#479	LASS5	4	10	14	748.227
#480	ZNF117	4	11	15	315.306
#481	MYT1	4	13	17	259.709
#482	FOXP3	4	13	17	609.036
#483	ZFP36L1	4	12	16	406.836
#484	BLZF1	4	10	14	221.68
#485	SLC2A4RG	4	12	16	399.672
#486	POU3F1	4	12	16	785.402
#487	HNRNPAB	3	14	17	230.914
#488	ZNF215	3	15	18	693.471
#489	SOX30	3	17	20	539.342
#490	CREBZF	3	9	12	507.844
#491	FOXE1	3	15	18	485.414
#492	SIX3	3	13	16	463.739
#493	PTH	3	12	15	231.812
#494	ANKRD30A	3	14	17	386.496
#495	KDM5A	3	16	19	330.205
#496	PCGF2	3	14	17	450.194
#497	RERE	2	11	13	266.054
#498	IKZF3	2	10	12	272.988
#499	FOXO1	2	14	16	177.9
#500	RCAN1	2	12	14	245.047