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Hub Rank	Node	Children	Parents	Degree	Betweenness
#1	FOXA1	76	1	77	128.737
#2	GTF2I	56	4	60	2380.955
#3	GABPB1	56	6	62	768.782
#4	GATA3	53	2	55	860.267
#5	SPDEF	51	6	57	259.095
#6	EN1	51	5	56	184.585
#7	FOXO1	51	7	58	2049.253
#8	ENO1	48	4	52	2982.381
#9	LMO4	47	9	56	2833.455
#10	XBP1	46	5	51	150.722
#11	ZEB1	43	10	53	1199.225
#12	TCF4	42	8	50	1536.579
#13	ESR1	42	6	48	255.936
#14	MAX	42	10	52	1233.438
#15	ZNF83	42	9	51	1784.698
#16	FOXM1	41	6	47	656.055
#17	RXRB	41	6	47	318.344
#18	MZF1	41	7	48	360.325
#19	MEOX2	41	6	47	216.198
#20	NFIL3	40	9	49	413.326
#21	SPEN	40	5	45	447.427
#22	FOXN3	39	7	46	913.545
#23	BACH2	39	8	47	1353.291
#24	ZFPM2	39	6	45	555.954
#25	AR	39	7	46	1513.582
#26	MEIS3P1	39	8	47	354.286
#27	RORC	38	11	49	2030.66
#28	RXRG	37	13	50	1883.75
#29	PTTG1	37	9	46	3675.624
#30	SIX6	37	11	48	1806.854
#31	GTF2H3	37	10	47	1104.687
#32	ZNF45	35	8	43	1125.355
#33	SNAI2	34	3	37	103.821
#34	SPIB	34	8	42	751.015
#35	MEOX1	34	8	42	273.427
#36	RUNX3	34	6	40	337.922
#37	TFDP1	33	16	49	1234.813
#38	NR2F2	33	11	44	1175.417
#39	PBX1	33	12	45	819.263
#40	TCEAL1	32	4	36	2095.764
#41	BHLHE41	32	7	39	719.594
#42	PBX2	32	14	46	2014.107
#43	ETV1	32	10	42	1607.013
#44	BHLHE40	32	14	46	2036.925
#45	ARNTL	32	12	44	1184.435
#46	ZNF165	31	17	48	3096.948
#47	MEF2C	31	10	41	527.415
#48	SOX10	30	5	35	122.044
#49	NFE2L3	30	10	40	2159.914
#50	MBD1	29	10	39	1020.65
#51	SATB1	29	14	43	3867.922
#52	HAND1	29	15	44	2918.01
#53	FOXC1	29	7	36	558.62
#54	ZNF277	28	12	40	4651.497
#55	HCLS1	28	3	31	68.607
#56	TP53	28	16	44	1516.411
#57	TWIST1	28	11	39	510.469
#58	HOXC8	28	14	42	2218.534
#59	SOX4	28	9	37	558.391
#60	TCF21	27	15	42	2027.62
#61	KLF5	27	12	39	1542.964
#62	IRF8	27	5	32	238.682
#63	TFEC	27	9	36	726.324
#64	MEIS2	27	11	38	587.419
#65	HEY2	27	17	44	3020.595
#66	TRPS1	27	7	34	489.622
#67	PRRX1	27	3	30	85.167
#68	TEAD1	27	3	30	601.789
#69	ZNF236	26	16	42	2876.779
#70	MSX1	26	10	36	413.054
#71	ARID3A	26	8	34	1079.11
#72	DLX4	26	15	41	2554.784
#73	HOXA7	26	11	37	1632.76
#74	TCF7L2	26	15	41	4013.788
#75	FLI1	26	13	39	736.62
#76	NR2F1	26	10	36	536.328
#77	RXRA	26	20	46	3312.318
#78	PCGF2	25	13	38	808.665
#79	CBFA2T3	24	10	34	510.955
#80	BATF	24	10	34	1365.125
#81	CDKN2A	24	8	32	296.446
#82	ZFP36L2	24	9	33	911.551
#83	SALL2	24	7	31	156.026
#84	ZEB2	24	13	37	504.599
#85	LASS2	23	11	34	1555.247
#86	TBX3	23	14	37	784.602
#87	ELK3	23	15	38	1131.239
#88	BTG2	23	11	34	629.168
#89	NR3C2	23	13	36	1566.308
#90	E2F8	23	5	28	100.255
#91	HOXB1	22	13	35	2057.476
#92	AFF1	22	16	38	4553.652
#93	NR3C1	22	6	28	1289.587
#94	HEYL	22	17	39	2186.809
#95	EPAS1	22	19	41	1250.977
#96	AEBP1	22	7	29	115.396
#97	TFAP2A	22	15	37	4568.227
#98	C11orf9	22	12	34	1376.756
#99	HHEX	22	20	42	1449.893
#100	ESRRG	22	16	38	2028.421
#101	TRIM22	22	7	29	380.717
#102	MEF2D	21	18	39	1511.602
#103	NPAT	21	13	34	1584.307
#104	TSC22D3	21	16	37	769.088
#105	ARNTL2	21	16	37	2411.391
#106	MYBL2	21	13	34	364.959
#107	TFAP2B	21	19	40	1665.344
#108	PROX1	21	16	37	2146.926
#109	KLF6	21	12	33	1931.145
#110	ETV5	21	12	33	1361.977
#111	IRX5	21	14	35	1751.19
#112	ZSCAN18	21	14	35	670.459
#113	NR2F6	20	16	36	1400.245
#114	NR4A2	20	21	41	1220.366
#115	STAT1	20	12	32	1338.194
#116	PPARG	20	14	34	1499.246
#117	MYC	20	16	36	2034.531
#118	GATA6	20	14	34	1365.404
#119	GAS7	20	8	28	1339.562
#120	BCL11B	20	7	27	381.449
#121	HOXA5	20	13	33	245.53
#122	HNF1B	20	17	37	1498.493
#123	JUN	20	11	31	657.376
#124	ZNF434	20	14	34	1417.655
#125	AHR	20	16	36	2089.991
#126	FUBP1	20	15	35	1585.559
#127	KLF2	20	17	37	747.694
#128	ZNF643	19	17	36	1927.204
#129	HOXD4	19	12	31	559.744
#130	E2F5	19	14	33	459.812
#131	ATF3	19	5	24	171.973
#132	STAT6	19	15	34	736.287
#133	MTA2	19	17	36	822.672
#134	BNC1	19	16	35	1846.723
#135	SP140	19	7	26	1355.659
#136	SATB2	19	15	34	1153.716
#137	HLF	19	20	39	656.555
#138	ELF5	18	9	27	171.225
#139	ARNT2	18	17	35	1421.265
#140	SP4	18	14	32	1097.681
#141	LHX6	18	9	27	1022.531
#142	CSDA	18	15	33	980.594
#143	HOXA10	18	14	32	2432.039
#144	VSX1	18	12	30	882.899
#145	ATF1	18	15	33	891.786
#146	SCML1	18	15	33	1110.57
#147	GATA2	18	15	33	563.364
#148	FOXE3	18	16	34	1737.246
#149	PEG3	17	28	45	6792.365
#150	NRL	17	13	30	1020.675
#151	C2orf3	17	11	28	1281.529
#152	HEY1	17	14	31	344.793
#153	PLSCR1	17	7	24	117.524
#154	OLIG2	17	19	36	1702.326
#155	RUNX1T1	17	16	33	329.833
#156	ASCL2	17	17	34	1320.068
#157	HOPX	17	13	30	332.244
#158	MSRB2	17	16	33	740.274
#159	HOXC11	17	11	28	862.773
#160	ELF4	17	14	31	799.919
#161	KLF9	17	16	33	1006.679
#162	TBX10	17	12	29	903.143
#163	SMAD1	16	20	36	1769.396
#164	IRF6	16	13	29	1497.085
#165	TADA2A	16	18	34	1407.679
#166	ZNF446	16	10	26	263.781
#167	ZGPAT	16	19	35	1628.457
#168	ZNF155	16	13	29	1038.062
#169	HOXB6	16	4	20	212.556
#170	CBFA2T2	16	21	37	1234.726
#171	FOS	16	5	21	657.009
#172	NR2C1	16	15	31	1326.421
#173	NR4A1	16	7	23	266.003
#174	TCF7L1	16	12	28	1619.394
#175	MMP14	16	17	33	1503.998
#176	VENTX	16	18	34	1133.447
#177	ZNF444	16	16	32	1510.331
#178	HOXB7	15	15	30	2700.455
#179	PRDM1	15	12	27	610.122
#180	ZNF91	15	13	28	771.682
#181	CEBPD	15	13	28	665.802
#182	RARG	15	19	34	1986.413
#183	TFAP2C	15	19	34	1405.358
#184	TCF3	15	14	29	638.589
#185	ERG	15	15	30	991.653
#186	FOSB	15	2	17	43.092
#187	ZNF167	15	20	35	1426.555
#188	CREB5	15	16	31	1449.608
#189	TFCP2L1	15	15	30	738.295
#190	ZNF132	15	15	30	1302.974
#191	RARA	15	16	31	796.533
#192	PGR	15	12	27	235.761
#193	MYOD1	15	13	28	1011.774
#194	OVOL1	15	16	31	654.776
#195	ZFP36L1	15	17	32	878.901
#196	BATF3	15	20	35	1558.074
#197	NPAS2	15	18	33	1329.813
#198	TCF7	15	14	29	254.744
#199	PAX6	14	10	24	559.577
#200	HOXB9	14	18	32	1666.344
#201	CITED2	14	12	26	614.993
#202	ZNF174	14	18	32	543.003
#203	ZFHX3	14	17	31	1314.675
#204	HOXD9	14	17	31	981.842
#205	LHX1	14	20	34	1558.926
#206	HOXA1	14	17	31	734.925
#207	MAFF	14	14	28	865.433
#208	HSF4	14	13	27	792.752
#209	HOXD13	14	19	33	1216.271
#210	NR1I3	14	11	25	1202.891
#211	FOSL1	14	20	34	775.987
#212	IKZF3	14	19	33	1081.051
#213	TBX19	14	17	31	557.818
#214	PPARA	14	13	27	2145.503
#215	ISL1	14	18	32	1545.09
#216	TFEB	14	19	33	1353.594
#217	HIC1	14	17	31	1047.874
#218	EGR3	14	10	24	342.02
#219	POU3F2	14	12	26	845.699
#220	KLF15	14	15	29	1442.762
#221	SIM2	14	23	37	1045.585
#222	ALX4	13	15	28	1438.635
#223	ESRRB	13	11	24	906.497
#224	ATOH1	13	16	29	802.281
#225	NR4A3	13	11	24	597.099
#226	NEUROG1	13	15	28	1026.704
#227	PRRX2	13	15	28	524.017
#228	HOXC13	13	14	27	949.668
#229	RCAN1	13	19	32	1251.509
#230	RFX3	13	8	21	1195.527
#231	ESR2	13	19	32	2425.682
#232	SIM1	13	20	33	2067.754
#233	ESRRA	13	14	27	630.469
#234	NFIB	13	12	25	1026.014
#235	JUND	13	12	25	464.929
#236	BLZF1	13	19	32	1996.863
#237	TADA3	13	18	31	1381.111
#238	TAF1B	12	16	28	883.33
#239	TSC22D2	12	13	25	2013.429
#240	WNT5A	12	14	26	1103.971
#241	ATF6	12	16	28	1418.618
#242	THRA	12	22	34	1479.615
#243	IRF7	12	9	21	2523.814
#244	SPI1	12	15	27	1967.219
#245	ZNF500	12	22	34	1492.343
#246	EGR1	12	9	21	763.427
#247	NR5A2	12	20	32	610.022
#248	MYT1	12	20	32	814.164
#249	EHF	12	15	27	859.478
#250	E2F1	12	11	23	502.249
#251	FOXL2	12	16	28	1692.373
#252	SOX9	12	17	29	719.917
#253	NFATC4	12	17	29	852.911
#254	SOX11	12	11	23	795.333
#255	ZBTB48	12	15	27	1113.031
#256	SOX21	12	13	25	634.125
#257	IRF5	12	10	22	973.408
#258	TP63	12	17	29	946.093
#259	HOXC5	12	17	29	1863.43
#260	TLX1	12	18	30	968.805
#261	HMGA1	12	17	29	889.55
#262	MYCN	11	17	28	965.874
#263	FOXP3	11	17	28	1248.441
#264	SNAPC4	11	14	25	810.768
#265	LEF1	11	21	32	959.718
#266	EGR2	11	11	22	735.186
#267	NKX3-2	11	10	21	457.983
#268	HMG20B	11	19	30	1863.977
#269	MAF	11	14	25	675.46
#270	PHF1	11	22	33	1373.281
#271	YY1	11	16	27	909.71
#272	HOXA9	11	12	23	1337.819
#273	HOXB2	11	9	20	387.986
#274	NFIX	11	18	29	658.215
#275	NR0B1	11	19	30	1621.832
#276	SALL1	11	13	24	739.774
#277	POU2F2	11	15	26	934.876
#278	HOXB5	11	7	18	1032.752
#279	TBX2	11	14	25	728.824
#280	MLL	11	20	31	950.054
#281	ZBTB17	11	21	32	1183.649
#282	CREB3L1	11	16	27	891.836
#283	RUNX2	11	17	28	854.418
#284	TP73	11	13	24	504.057
#285	MYOG	11	15	26	3078.545
#286	TCF12	11	18	29	881.65
#287	SP1	11	13	24	729.559
#288	ETV2	11	23	34	821.855
#289	TRIM29	11	11	22	1260.176
#290	SREBF1	11	15	26	277.721
#291	GATA1	10	18	28	2083.775
#292	NFYA	10	16	26	460.264
#293	GATA4	10	21	31	940.546
#294	NKX3-1	10	17	27	689.213
#295	HOXC10	10	10	20	281.352
#296	ZNF41	10	16	26	1484.806
#297	TSHZ2	10	11	21	271.746
#298	ZIC3	10	16	26	664.557
#299	MYF6	10	18	28	1754.557
#300	NKX2-1	10	17	27	2757.69
#301	KLF4	10	14	24	892.745
#302	E2F2	10	13	23	576.339
#303	NANOG	10	15	25	1285.675
#304	MECOM	10	21	31	1767.439
#305	WT1	10	24	34	1558.872
#306	PAX5	10	17	27	891.484
#307	PPBPL2	10	20	30	1173.319
#308	STRN3	10	16	26	698.978
#309	NPAS1	10	25	35	719.687
#310	IRX4	10	19	29	629.043
#311	USF2	10	18	28	1554.798
#312	POU2F3	10	21	31	679.469
#313	HOXD10	10	20	30	1029.596
#314	PKNOX2	10	16	26	999.095
#315	SIX2	10	19	29	750.533
#316	HMBOX1	10	18	28	1902.434
#317	MXD1	10	16	26	856.438
#318	NR2E3	10	18	28	829.784
#319	NFX1	10	22	32	1208.349
#320	FOXI1	10	27	37	1294.979
#321	LHX2	10	18	28	976.502
#322	TFAP4	10	18	28	776.124
#323	SOX18	10	11	21	739.49
#324	FOXD1	10	16	26	813.602
#325	IKZF1	10	19	29	2380.92
#326	TBX1	10	19	29	1002.836
#327	ALX1	10	12	22	963.32
#328	ZNF117	10	9	19	367.923
#329	ASCL1	10	21	31	959.544
#330	SOX30	10	19	29	1044.273
#331	TEF	10	22	32	684.813
#332	POU5F1B	9	18	27	838.463
#333	RBPJL	9	13	22	770.349
#334	SMAD3	9	22	31	830.919
#335	MLXIPL	9	19	28	1139.932
#336	SCAND2	9	20	29	1266.704
#337	MYCL1	9	23	32	1238.952
#338	RFXAP	9	20	29	1024.573
#339	HAND2	9	19	28	1006.254
#340	GLI2	9	20	29	2248.621
#341	BRD8	9	22	31	869.963
#342	NKX6-1	9	15	24	1659.981
#343	ZFP37	9	14	23	638.747
#344	SLC26A3	9	20	29	339.545
#345	NR1I2	9	23	32	882.537
#346	TAL1	9	15	24	644.56
#347	HR	9	19	28	805.557
#348	HOXA2	9	15	24	353.332
#349	CREBBP	9	20	29	756.884
#350	SNAPC5	9	19	28	829.263
#351	TBR1	9	16	25	1035.514
#352	RB1	9	17	26	1006.445
#353	ALX3	9	21	30	1254.174
#354	MSX2	9	13	22	393.568
#355	ETV3	9	13	22	771.981
#356	REL	9	16	25	1124.758
#357	CEBPA	9	19	28	1056.44
#358	ZNF215	9	16	25	1038.891
#359	PPARD	9	15	24	982.508
#360	NFATC3	9	19	28	632.851
#361	HOXA3	9	18	27	876.834
#362	LZTS1	9	14	23	1499.829
#363	E2F4	9	16	25	1320.324
#364	POU3F1	8	21	29	1359.457
#365	FOXH1	8	16	24	787.852
#366	NFAT5	8	15	23	344.633
#367	ETV4	8	18	26	1069.767
#368	PTH	8	13	21	949.494
#369	TFDP3	8	13	21	424.59
#370	ZNF323	8	18	26	1003.523
#371	ATF5	8	17	25	1136.007
#372	ZNF81	8	20	28	996.739
#373	LMX1B	8	21	29	613.82
#374	POU6F1	8	18	26	932.112
#375	CREM	8	20	28	536.185
#376	TCF15	8	13	21	702.227
#377	HOXD11	8	13	21	890.032
#378	PKNOX1	8	17	25	466.746
#379	ST18	8	18	26	686.73
#380	STAT2	8	21	29	1469.083
#381	SIX3	8	15	23	653.419
#382	ZNF287	8	22	30	1098.977
#383	DLX6	8	14	22	452.109
#384	KLF12	8	18	26	947.931
#385	VDR	8	19	27	1387.821
#386	ZHX3	8	20	28	963.75
#387	PITX2	8	15	23	559.063
#388	T	8	14	22	703.301
#389	CREBZF	8	19	27	1105.994
#390	HOXA11	8	16	24	1005.851
#391	PITX3	8	12	20	915.641
#392	HNF4A	8	16	24	1796.907
#393	CITED1	8	19	27	985.345
#394	PHOX2B	8	13	21	610.857
#395	MNX1	8	22	30	1566.789
#396	PRDM2	8	19	27	513.542
#397	RUNX1	8	25	33	632.563
#398	NR2E1	8	9	17	220.776
#399	FOXO3	8	23	31	730.604
#400	GBX2	7	22	29	617.288
#401	POU4F1	7	13	20	226.598
#402	SOX5	7	16	23	604.764
#403	ARNT	7	23	30	829.687
#404	NKX2-8	7	18	25	919.82
#405	ZNF135	7	17	24	598.026
#406	BARX1	7	15	22	750.533
#407	GCM1	7	21	28	1036.98
#408	ATF6B	7	19	26	450.546
#409	HOXB3	7	16	23	673.978
#410	MAFK	7	18	25	937.132
#411	NFKB2	7	24	31	947.721
#412	ZKSCAN1	7	22	29	263.576
#413	SCRT1	7	19	26	820.979
#414	HES1	7	20	27	1721.244
#415	NR6A1	7	19	26	481.33
#416	FOXO4	7	21	28	920.513
#417	EN2	7	21	28	902.434
#418	SMAD9	7	12	19	462.318
#419	HOXD1	7	17	24	799.225
#420	PAX4	7	16	23	665.011
#421	SOX15	7	17	24	531.113
#422	FOSL2	7	18	25	1296.769
#423	HOXB8	6	13	19	359.9
#424	HMX1	6	15	21	265.758
#425	FOXD3	6	20	26	673.095
#426	ZIC1	6	17	23	123.044
#427	NR5A1	6	18	24	327.057
#428	FOXD2	6	23	29	392.002
#429	NFE2	6	18	24	1119.631
#430	PDX1	6	19	25	650.264
#431	POU6F2	6	17	23	551.521
#432	MLLT10	6	18	24	1189.582
#433	RERE	6	22	28	757.942
#434	PITX1	6	24	30	1107.361
#435	PLAG1	6	20	26	762.264
#436	NEUROD1	6	15	21	535.493
#437	ONECUT1	6	19	25	773.852
#438	TAF4	6	15	21	326.055
#439	EMX1	6	19	25	423.562
#440	ZNF238	6	17	23	561.841
#441	FOXE1	6	23	29	731.66
#442	TAF13	6	21	27	1659.963
#443	EGR4	6	16	22	366.944
#444	MYF5	6	21	27	1331.48
#445	CUX2	6	13	19	721.466
#446	ZNF3	6	19	25	497.85
#447	TLX2	6	13	19	313.894
#448	CSRNP3	6	16	22	403.036
#449	ZSCAN12	6	19	25	762.571
#450	IRF4	6	22	28	797.927
#451	KDM5B	6	23	29	943.142
#452	DLX2	5	16	21	784.218
#453	KLF1	5	15	20	673.763
#454	FOXJ1	5	21	26	710.79
#455	FOXG1	5	20	25	817.906
#456	SIX1	5	15	20	339.374
#457	CRX	5	19	24	568.387
#458	NKX2-5	5	17	22	302.068
#459	POU3F4	5	19	24	1191.21
#460	FOXB1	5	16	21	267.286
#461	VTN	5	21	26	720.24
#462	DMRT1	5	15	20	255.576
#463	CEBPE	5	19	24	581.797
#464	ONECUT2	5	18	23	552.94
#465	ZNF154	5	16	21	320.69
#466	HOXD3	5	19	24	446.26
#467	TBX5	5	10	15	289.963
#468	ZNF639	5	23	28	1895.373
#469	HIF3A	4	17	21	883.915
#470	ELK1	4	22	26	421.566
#471	POU3F3	4	18	22	382.123
#472	ELK4	4	18	22	649.538
#473	ZNF80	4	20	24	707.273
#474	SMAD6	4	20	24	488.088
#475	NR1H4	4	20	24	746.073
#476	HOXB13	4	26	30	558.131
#477	FOXC2	3	18	21	253.291
#478	ZSCAN2	3	18	21	364.215
#479	RORB	3	22	25	448.336
#480	RARB	3	19	22	353.106
#481	PAX7	3	20	23	312.45
#482	SOX2	3	20	23	691.456
#483	POU4F3	3	21	24	339.526
#484	ZNF202	3	18	21	557.158
#485	MYT1L	3	16	19	190.718
#486	ZNF157	3	19	22	241.743
#487	DBP	3	19	22	233.178
#488	PAX3	3	20	23	289.267
#489	PAX8	3	21	24	380.394
#490	REST	3	19	22	145.418
#491	PHOX2A	3	20	23	423.221
#492	FOXA2	3	14	17	297.284
#493	TBX6	3	20	23	218.262
#494	HNF4G	3	21	24	309.11
#495	GSC2	2	21	23	141.271
#496	NFATC1	2	18	20	164.435
#497	HESX1	2	21	23	119.984
#498	POU1F1	2	24	26	792.77
#499	SRY	1	18	19	134.656
#500	TLX3	1	23	24	81.202