Hub Rank	Node	Children	Parents	Degree	Betweenness
#1	ZEB2	70	2	72	376.437
#2	FOXF1	57	5	62	204.115
#3	NKX2-3	54	7	61	2096.202
#4	TCF4	54	5	59	7055.642
#5	TSHZ3	53	3	56	281.695
#6	PTTG1	47	4	51	775.672
#7	MEF2C	46	5	51	501.717
#8	TCF7L1	39	10	49	484.534
#9	ZSCAN18	38	4	42	163.608
#10	GTF2H3	38	6	44	602.587
#11	NOLC1	36	7	43	794.522
#12	NFIB	35	12	47	6548.667
#13	NFE2L3	35	5	40	1708.215
#14	MEIS1	35	11	46	652.323
#15	PEG3	34	7	41	540.651
#16	AEBP1	34	5	39	490.669
#17	EBF1	34	6	40	191.654
#18	FOXF2	34	8	42	5450.546
#19	GATA2	33	8	41	887.462
#20	SP4	33	5	38	1193.475
#21	TSC22D3	32	6	38	332.939
#22	GLI3	32	6	38	196.233
#23	GAS7	32	10	42	354.329
#24	TBX2	31	7	38	3680.525
#25	TCF21	31	9	40	1528.852
#26	HNRNPK	31	5	36	500.246
#27	SLC26A3	31	10	41	8006.566
#28	REST	30	12	42	4541.674
#29	LEF1	30	11	41	2873.903
#30	HNF1A	29	9	38	4358.164
#31	SMAD4	28	5	33	1892.201
#32	IRF7	28	2	30	312.079
#33	PKNOX2	28	10	38	5356.354
#34	ZFP42	27	13	40	1251.438
#35	ZNF219	27	9	36	334.871
#36	UHRF1	26	5	31	196.74
#37	TADA2A	26	9	35	2671.262
#38	RUNX1T1	26	10	36	243.25
#39	HCLS1	25	4	29	77.48
#40	CBFA2T3	25	17	42	9025.219
#41	SOLH	25	12	37	4537.856
#42	SNAI2	23	12	35	1827.536
#43	HOPX	23	12	35	2415.779
#44	FOXM1	23	6	29	278.033
#45	SIX4	23	11	34	3086.988
#46	ETV4	22	9	31	2919.403
#47	KLF2	22	13	35	394.272
#48	SOX18	22	8	30	197.566
#49	E2F1	22	13	35	1363.373
#50	HOXB1	22	4	26	417.178
#51	E2F7	21	6	27	2159.472
#52	ZNF135	21	12	33	984.975
#53	TSHZ2	21	10	31	496.561
#54	PBX3	21	4	25	109.106
#55	POU2F2	21	11	32	843.574
#56	E2F8	21	6	27	1100.244
#57	STAT5A	21	12	33	3100.393
#58	NKX3-1	21	9	30	1048.859
#59	ATF1	21	9	30	543.957
#60	NFIX	21	11	32	3953.251
#61	TEAD4	20	12	32	913.238
#62	BTG2	20	10	30	1097.627
#63	KLF6	20	8	28	898.839
#64	DLX2	20	4	24	410.115
#65	ETV5	20	8	28	2054.34
#66	FOXD1	20	15	35	4290.144
#67	HMGB2	20	5	25	478.93
#68	NR5A2	19	12	31	1487.19
#69	PAX7	19	5	24	347.224
#70	RCAN1	19	14	33	3566.675
#71	MECOM	19	6	25	915.129
#72	MSX1	19	17	36	3013.587
#73	POU4F1	18	14	32	1961.199
#74	ELF3	18	10	28	1864.473
#75	SPI1	18	6	24	259.547
#76	SOX9	18	10	28	657.422
#77	KLF4	17	12	29	9090.108
#78	KLF9	17	13	30	791.313
#79	HOXD11	17	7	24	1686.719
#80	SOX30	17	11	28	3127.318
#81	FOSB	17	7	24	713.965
#82	BATF2	17	12	29	2110.277
#83	GTF2H2	17	11	28	2461.227
#84	PURA	17	9	26	1775.427
#85	FOXA3	16	6	22	266.71
#86	SATB2	16	8	24	603.988
#87	NFIA	16	9	25	2167.456
#88	MEOX1	16	10	26	216.009
#89	PRRX1	16	14	30	2044.568
#90	LHX6	16	13	29	2619.618
#91	HOXC8	16	9	25	1264.118
#92	MEOX2	16	9	25	2105.405
#93	MZF1	16	8	24	9053.786
#94	ZEB1	16	11	27	312.185
#95	FOXN3	16	9	25	2095.154
#96	LZTS1	16	9	25	546.436
#97	NR3C2	15	11	26	854.494
#98	ZNF3	15	8	23	853.564
#99	RUNX3	15	11	26	1970.518
#100	WNT5A	15	14	29	1476.886
#101	RARB	15	13	28	9449.985
#102	TFAP4	15	11	26	2505.49
#103	ONECUT1	15	8	23	3118.214
#104	GRHL2	15	9	24	1789.335
#105	ZNF165	15	13	28	13385.236
#106	E2F5	15	10	25	869.097
#107	IRF6	15	8	23	822.268
#108	ZNF628	14	13	27	9017.962
#109	FOXA2	14	9	23	1059.386
#110	PHOX2B	14	13	27	1029.896
#111	SMAD9	14	16	30	4215.607
#112	NRL	14	14	28	3123.368
#113	MAF	14	10	24	921.594
#114	RXRG	14	13	27	1971.765
#115	ZNF71	14	12	26	1120.076
#116	SMAD6	14	11	25	1197.012
#117	TRIM22	14	9	23	270.633
#118	CSRNP1	14	8	22	1157.708
#119	ZNF202	14	6	20	749.945
#120	ADNP	14	11	25	3289.477
#121	SOX5	14	10	24	2665.602
#122	AFF4	14	7	21	414.324
#123	TEF	14	9	23	374.879
#124	ARID4A	14	10	24	2813.809
#125	YEATS4	14	8	22	335.295
#126	IRX5	14	12	26	1574.366
#127	HOXB9	14	7	21	907.604
#128	HOXB8	14	8	22	1515.946
#129	PROX1	14	9	23	369.944
#130	ATF7	14	10	24	2013.55
#131	FOXE3	13	7	20	1453.344
#132	NFATC4	13	9	22	431.099
#133	TP53	13	7	20	1995.287
#134	CTBP1	13	9	22	349.246
#135	ZFP37	13	14	27	1429.334
#136	CITED2	13	10	23	682.308
#137	ZNF256	13	11	24	535.908
#138	TBX4	13	7	20	1729.969
#139	HOXA10	13	8	21	1926.373
#140	OVOL1	13	9	22	742.492
#141	DBP	13	12	25	1197.192
#142	HOXB6	13	6	19	971.912
#143	NR4A2	13	10	23	329.945
#144	BCL11B	13	10	23	6046.189
#145	ASCL2	13	11	24	438.197
#146	GTF2IRD1	13	8	21	597.747
#147	TWIST1	13	10	23	2093.23
#148	NME2	13	9	22	1433.44
#149	EHF	13	9	22	797.429
#150	SIM2	13	16	29	3180.36
#151	LBX2	13	12	25	1299.661
#152	HEYL	12	7	19	427.946
#153	PBX1	12	9	21	2544.313
#154	PCGF6	12	15	27	1768.993
#155	ZKSCAN5	12	9	21	1126.288
#156	ZNF174	12	11	23	3374.941
#157	ARID3A	12	13	25	1664.432
#158	ZSCAN29	12	11	23	1682.868
#159	TRIM29	12	12	24	1494.981
#160	NKX3-2	12	10	22	807.926
#161	GSC2	12	17	29	4483.805
#162	HAND1	12	12	24	657.305
#163	HOXB2	12	9	21	394.97
#164	TRPS1	12	9	21	192.502
#165	PRRX2	12	12	24	2132.426
#166	HMGA2	12	10	22	535.576
#167	HNF1B	12	9	21	673.265
#168	GTF2I	12	13	25	10723.282
#169	TFCP2L1	12	9	21	550.096
#170	FOXD2	12	12	24	1432.042
#171	TCF19	12	10	22	230.769
#172	HNF4G	12	8	20	747.667
#173	C11orf9	12	8	20	972.126
#174	ZNF274	11	13	24	641.592
#175	HOXC6	11	15	26	1356.194
#176	ZIC2	11	14	25	1223.498
#177	FOXA1	11	14	25	3799.524
#178	ZFHX4	11	10	21	1063.909
#179	NR3C1	11	11	22	286.65
#180	ZFPM2	11	11	22	480.46
#181	TGIF1	11	14	25	2101.004
#182	RUNX1	11	12	23	378.707
#183	IKZF1	11	12	23	317.626
#184	TFAP2A	11	11	22	4329.296
#185	HOXA13	11	18	29	9701.539
#186	ISL2	11	13	24	1121.026
#187	SOX7	11	10	21	853.771
#188	FOXO3	11	10	21	740.144
#189	KLF10	11	12	23	634.709
#190	NR1D2	11	14	25	7779.683
#191	POU4F3	11	11	22	4209.447
#192	ZNF268	11	10	21	4406.193
#193	EGR4	11	14	25	1195.73
#194	MESP1	11	10	21	1922.611
#195	HOXA11	11	12	23	2441.16
#196	SCML1	11	15	26	781.229
#197	NPAS2	11	14	25	731.421
#198	CITED1	11	10	21	1506.708
#199	CEBPD	11	10	21	1801.459
#200	EN1	11	8	19	2031.248
#201	SALL2	10	11	21	333.92
#202	TSC22D2	10	4	14	136.692
#203	PRDM1	10	10	20	820.61
#204	FOXQ1	10	10	20	185.939
#205	MNX1	10	8	18	682.209
#206	ELK3	10	13	23	2121.267
#207	SOX4	10	12	22	425.774
#208	KCNH8	10	16	26	673.222
#209	ATOH1	10	12	22	2357.851
#210	SOX11	10	11	21	1693.338
#211	ZNF134	10	7	17	635.866
#212	SREBF1	10	14	24	1715.537
#213	SOX17	10	9	19	1703.106
#214	TPRX1	10	10	20	2357.664
#215	HOXC9	10	8	18	312.711
#216	ZNF397	10	11	21	1584.525
#217	IRF4	10	14	24	2990.027
#218	ELK4	10	9	19	372.157
#219	ESR1	10	9	19	369.801
#220	HES6	10	12	22	1056.401
#221	AR	10	13	23	2162.589
#222	TFDP3	10	11	21	1607.333
#223	BHLHE41	10	14	24	4115.908
#224	SIX1	10	15	25	4140.485
#225	KLF5	10	16	26	1551.717
#226	ZSCAN2	10	10	20	2436.295
#227	PTH	9	10	19	944.232
#228	RORB	9	10	19	296.916
#229	TBX10	9	14	23	994.116
#230	ZNF483	9	11	20	737.281
#231	ZNF167	9	12	21	533.186
#232	HOXB13	9	15	24	4056.638
#233	ARGFX	9	10	19	1519.834
#234	NPAS1	9	11	20	406.477
#235	HOXD4	9	12	21	4822.87
#236	CREB3L1	9	10	19	2920.314
#237	CNOT7	9	7	16	1209.945
#238	ISX	9	15	24	494.132
#239	ZSCAN10	9	12	21	3194.985
#240	IRX2	9	13	22	984.854
#241	PLAG1	9	17	26	4144.331
#242	DLX4	9	15	24	1002.441
#243	CREB5	9	13	22	420.278
#244	CDKN2A	9	8	17	1004.623
#245	ATF3	9	10	19	992.077
#246	MSX2	9	14	23	1969.095
#247	CEBPA	9	12	21	1221.361
#248	GABPA	9	5	14	59.063
#249	MEIS2	9	13	22	233.198
#250	HIC1	9	12	21	1749.871
#251	TCF7	9	9	18	320.77
#252	FOXN1	9	12	21	2377.286
#253	MXD1	8	10	18	458.21
#254	HNF4A	8	15	23	500.906
#255	CTNNB1	8	7	15	1949.623
#256	ZNF132	8	11	19	398.759
#257	PBX4	8	10	18	793.015
#258	ETS1	8	11	19	3005.958
#259	SOX10	8	16	24	638.529
#260	TLX2	8	12	20	988.424
#261	GLIS2	8	14	22	2959.99
#262	RUNX2	8	16	24	859.59
#263	EGR1	8	15	23	521.368
#264	HOXD9	8	13	21	1373.463
#265	HOXB3	8	8	16	527.287
#266	NR1I2	8	12	20	383.976
#267	SP3	8	19	27	1638.418
#268	MYOG	8	11	19	1345.563
#269	ISL1	8	14	22	1153.674
#270	BACH2	8	10	18	988.761
#271	HOXD10	8	14	22	830.931
#272	ZNF169	8	12	20	1615.834
#273	FOXD3	8	12	20	1594.991
#274	EGR2	8	7	15	138.583
#275	ZNF75D	8	13	21	1021.171
#276	TAF13	8	15	23	911.545
#277	HOXC10	8	11	19	1261.68
#278	ARNTL	7	11	18	643.714
#279	OTX1	7	10	17	4146.789
#280	FOS	7	9	16	1486.905
#281	LHX2	7	12	19	1232.639
#282	ZNF197	7	11	18	5860.259
#283	TADA3	7	12	19	6210.185
#284	HR	7	4	11	151.963
#285	IRX3	7	20	27	2781.922
#286	MLXIPL	7	12	19	2133.279
#287	TSC22D1	7	10	17	534.748
#288	NFATC1	7	8	15	341.126
#289	HLF	7	15	22	526.849
#290	PAX6	7	15	22	2258.008
#291	FOXS1	7	10	17	191.583
#292	NKX2-5	7	10	17	751.581
#293	BATF	7	16	23	453.559
#294	IRF8	7	13	20	504.308
#295	FBXW7	7	15	22	4003.995
#296	EOMES	7	10	17	1754.699
#297	LHX1	7	11	18	3518.978
#298	HIF3A	7	12	19	755.625
#299	E2F2	7	9	16	339.813
#300	FOXE1	7	14	21	2568.161
#301	CREB3L4	7	10	17	1010.249
#302	ZNF33A	7	17	24	2295.377
#303	SOX12	7	14	21	4980.193
#304	SOX15	7	14	21	522.098
#305	POU5F1	6	15	21	3326.372
#306	HOXB4	6	14	20	1033.107
#307	DLX1	6	15	21	1846.349
#308	NFIC	6	9	15	1153.518
#309	CDX2	6	11	17	443.06
#310	TFAP2E	6	6	12	2014.469
#311	TFAP2C	6	12	18	579.251
#312	TCF12	6	14	20	1657.971
#313	HOXD1	6	16	22	849.112
#314	PAX4	6	10	16	662.882
#315	GSX2	6	15	21	2130.632
#316	ZNF138	6	13	19	702.861
#317	MYOD1	6	12	18	1375.718
#318	ZXDA	6	7	13	792.553
#319	TFEB	6	10	16	213.293
#320	MYCN	6	10	16	483.637
#321	FOXB2	6	8	14	712.585
#322	NR1H4	6	14	20	2243.615
#323	BNC1	6	1	7	893.111
#324	NR4A1	6	10	16	649.84
#325	CUX1	6	12	18	1100.732
#326	MAX	6	11	17	1313.759
#327	ARNT2	6	13	19	1116.452
#328	MAFB	6	8	14	113.758
#329	VSX1	6	14	20	1179.428
#330	TBR1	6	9	15	788.304
#331	NR2E3	6	11	17	657.109
#332	EN2	6	12	18	1045.742
#333	TGIF2LX	6	15	21	4975.158
#334	NR4A3	6	13	19	1611.744
#335	VAV1	6	10	16	510.981
#336	DMBX1	6	10	16	245.866
#337	GBX2	6	13	19	918.489
#338	FOXC2	6	10	16	537.58
#339	PPARG	6	7	13	191.037
#340	IRF5	6	12	18	1236.195
#341	FOXL2	6	5	11	2048.939
#342	ALS2CR8	6	17	23	1573.357
#343	ONECUT2	5	14	19	727.615
#344	HOXC5	5	13	18	2010.652
#345	MYT1	5	11	16	833.361
#346	RARA	5	8	13	853.832
#347	NKX6-2	5	10	15	687.106
#348	ZSCAN20	5	15	20	1712.913
#349	LHX3	5	8	13	352.315
#350	HESX1	5	13	18	1905.276
#351	FOXC1	5	12	17	379.992
#352	ZNF19	5	8	13	822.346
#353	NKX2-1	5	7	12	648.61
#354	RFX3	5	16	21	868.531
#355	SOX6	5	12	17	3180.426
#356	GATA3	5	12	17	332.576
#357	STAT4	5	17	22	1559.226
#358	NFYA	5	13	18	856.608
#359	PAX8	5	13	18	561.147
#360	BACH1	5	12	17	464.111
#361	DBX1	5	14	19	1690.189
#362	SOX1	5	16	21	3009.163
#363	ASCL1	5	13	18	1306.138
#364	TBPL2	5	12	17	1769.947
#365	TEAD1	5	10	15	875.968
#366	ZIM2	5	7	12	188.961
#367	GSX1	5	17	22	2915.072
#368	HOXA3	5	14	19	1258.026
#369	HOXC4	5	10	15	2175.117
#370	HOXD13	5	15	20	701.711
#371	SOX8	5	11	16	222.761
#372	SATB1	5	11	16	509.415
#373	TCEAL1	5	11	16	667.014
#374	FOXD4	5	8	13	242.439
#375	GRHL3	5	12	17	420.124
#376	NFE2	5	17	22	1118.991
#377	POU3F1	5	9	14	364.235
#378	DMRT2	5	15	20	3325.98
#379	FOXR1	5	11	16	3049.236
#380	FEV	5	13	18	1404.612
#381	VENTX	5	14	19	11492.975
#382	USF2	5	12	17	9557.444
#383	FOXI1	5	9	14	610.167
#384	VDR	5	14	19	592.663
#385	TP63	4	10	14	335.208
#386	DLX3	4	13	17	263.115
#387	SOX21	4	18	22	1131.357
#388	GCM1	4	9	13	960.675
#389	MITF	4	16	20	633.607
#390	HOXA9	4	13	17	857.017
#391	TCF15	4	11	15	137.017
#392	TLX1	4	15	19	333.245
#393	ZNF287	4	8	12	263.453
#394	NKX6-1	4	13	17	1729.213
#395	C2orf3	4	13	17	3116.015
#396	HES5	4	13	17	620.975
#397	TRERF1	4	14	18	2531.665
#398	TBX5	4	10	14	508.192
#399	CBFA2T2	4	13	17	340.031
#400	ZNF639	4	13	17	948.987
#401	MYC	4	8	12	199.647
#402	ZNF449	4	12	16	1002.43
#403	CUX2	4	15	19	644.414
#404	SMAD5	4	14	18	457.124
#405	FOXP2	4	16	20	138.776
#406	CREB3L3	4	11	15	768.841
#407	FOXN4	4	16	20	325.932
#408	ELF5	4	12	16	853.36
#409	PAX3	4	14	18	2404.834
#410	TBX1	4	10	14	649.981
#411	ZNF155	4	14	18	1843.381
#412	RORA	4	12	16	179.754
#413	MAFF	4	11	15	584.368
#414	FOSL1	4	11	15	269.699
#415	POU4F2	4	11	15	913.029
#416	BHLHE40	4	12	16	282.108
#417	GATA4	4	13	17	1895.225
#418	HOXD8	4	14	18	544.441
#419	PITX2	4	14	18	1868.037
#420	ZNF41	4	15	19	2036.966
#421	TP73	4	9	13	582.545
#422	HOXC11	4	10	14	284.377
#423	MKX	4	17	21	1277.423
#424	SPIB	4	12	16	664.931
#425	FOXD4L1	4	10	14	553.242
#426	BCL3	3	7	10	398.506
#427	NFATC2	3	12	15	1679.51
#428	ZNF396	3	10	13	551.417
#429	SHOX	3	16	19	2772.973
#430	ERG	3	7	10	151.248
#431	JUNB	3	10	13	343.465
#432	ZNF81	3	14	17	461.054
#433	HAND2	3	13	16	1140.983
#434	ZNF85	3	12	15	267.805
#435	FOXP1	3	9	12	105.052
#436	ZNF643	3	9	12	153.562
#437	EMX1	3	10	13	739.559
#438	ZNF93	3	14	17	949.49
#439	SIM1	3	13	16	568.771
#440	ESRRG	3	9	12	153.031
#441	POU3F2	3	5	8	3252.015
#442	GSC	3	9	12	453.745
#443	POU3F3	3	15	18	1100.612
#444	TGIF2LY	3	13	16	1063.865
#445	KLF12	3	12	15	561.836
#446	GATA5	3	6	9	669.114
#447	RHOXF1	3	13	16	498.273
#448	PITX3	3	12	15	506.93
#449	ALX1	3	15	18	741.966
#450	NFATC3	3	13	16	405.241
#451	RCOR1	3	18	21	1041.997
#452	NKX2-8	3	12	15	511.45
#453	BRD8	3	13	16	765.268
#454	L3MBTL4	3	10	13	1586.073
#455	ZSCAN4	3	12	15	365.223
#456	NEUROD1	3	8	11	1860.629
#457	SP140	3	9	12	210.77
#458	PPARD	3	12	15	439.567
#459	NR1D1	3	10	13	552.042
#460	ZNF117	3	14	17	1540.923
#461	MYT1L	3	10	13	1518.073
#462	HSF4	3	16	19	1490.686
#463	RARG	3	8	11	529.909
#464	POU2F3	3	9	12	527.068
#465	PAX5	3	12	15	846.517
#466	LHX4	3	14	17	190.426
#467	LHX9	2	12	14	755.117
#468	VTN	2	11	13	160.196
#469	ETV3L	2	12	14	367.854
#470	FOXJ1	2	17	19	479.813
#471	POU1F1	2	14	16	2032.309
#472	MSL3	2	9	11	857.184
#473	FOXD4L4	2	8	10	134.524
#474	HMX2	2	9	11	214.654
#475	ZNF92	2	12	14	3667.603
#476	TFAP2D	2	10	12	679.907
#477	SIX2	2	11	13	315.402
#478	IRX4	2	11	13	124.841
#479	SRY	2	15	17	626.221
#480	HOXA1	2	12	14	2051.782
#481	ZNF238	2	8	10	220.156
#482	RORC	2	10	12	759.694
#483	FOXB1	2	12	14	1282.694
#484	RBPJ	2	10	12	115.56
#485	ZNF70	2	9	11	425.654
#486	ESRRB	2	11	13	246.46
#487	PGR	2	12	14	73.105
#488	MMP14	2	16	18	1150.016
#489	GATA1	2	10	12	229.807
#490	TBX15	1	10	11	95.717
#491	HELT	1	11	12	42.031
#492	ETV1	1	10	11	93.087
#493	SMAD1	1	11	12	350.534
#494	FOXI2	1	14	15	104.902
#495	ZNF445	1	9	10	64.846
#496	DPRX	1	13	14	116.779
#497	HOXD12	1	10	11	243.034
#498	ST18	1	11	12	562.601
#499	ZHX1	0	7	7	0
#500	NEUROG1	0	12	12	0