Hub Rank	Node	Children	Parents	Degree	Betweenness
#1	EPAS1	74	0	74	0
#2	ERG	63	3	66	34.776
#3	TCF21	63	5	68	213.875
#4	HMGA1	54	9	63	2827.337
#5	FOXF1	50	2	52	16.015
#6	TAL1	46	2	48	1063.603
#7	ZEB1	45	7	52	1972.428
#8	TFAP2C	43	9	52	1101.2
#9	FOXM1	43	10	53	1174.611
#10	PTTG1	40	9	49	1056.021
#11	MYOG	40	0	40	0
#12	ENO1	39	12	51	662.677
#13	KLF4	39	8	47	274.031
#14	GATA6	38	10	48	318.161
#15	HMX1	36	2	38	123.691
#16	ZNF3	36	14	50	1555.92
#17	MYBL2	36	7	43	395.522
#18	PRRX2	35	7	42	623.404
#19	E2F8	34	12	46	14931.979
#20	MEIS1	34	7	41	270.098
#21	HOXA5	34	6	40	119.484
#22	KDM5B	33	13	46	1404.779
#23	GATA2	32	7	39	123.898
#24	MLXIPL	32	3	35	124.297
#25	ELK1	32	0	32	0
#26	ZNF207	31	7	38	1751.031
#27	HOXC8	31	2	33	58.373
#28	SOX13	31	9	40	276.547
#29	KLF2	31	7	38	2306.604
#30	CREBZF	30	7	37	1807.48
#31	NR3C1	30	10	40	1710.562
#32	E2F3	30	7	37	570.134
#33	KLF9	29	9	38	1846.865
#34	SMAD4	29	11	40	615.063
#35	TFDP1	28	12	40	4699.567
#36	MECOM	28	17	45	783.467
#37	ETV1	28	14	42	534.717
#38	ZEB2	28	10	38	2469.468
#39	TBX2	27	9	36	1002.166
#40	E2F4	27	4	31	474.554
#41	FUBP1	27	11	38	681.027
#42	RCAN1	27	10	37	460.659
#43	CREBL2	27	10	37	501.162
#44	FLI1	27	7	34	423.146
#45	ADNP	26	17	43	2746.261
#46	BUD31	26	12	38	1325.011
#47	HMGB2	26	14	40	1658.702
#48	HOPX	26	20	46	8812.598
#49	SIX3	25	12	37	6572.115
#50	GTF2IRD1	25	10	35	344.618
#51	GTF2H4	25	10	35	1690.64
#52	HMG20A	25	7	32	668.254
#53	SOX10	25	5	30	77.854
#54	PKNOX2	25	14	39	1210.739
#55	FOXO3	25	13	38	1015.767
#56	ATF2	25	11	36	827.146
#57	MAFF	24	8	32	444.685
#58	TBX3	24	9	33	1595.386
#59	SOX4	24	12	36	1302.117
#60	BLZF1	24	11	35	3639.19
#61	HDAC1	24	15	39	3302.013
#62	NR1I2	24	3	27	43.513
#63	TCF3	24	10	34	1539.675
#64	NR2C1	24	16	40	3299.303
#65	FOXL1	23	5	28	1651.149
#66	HSF2	23	11	34	811.302
#67	SNAPC2	23	5	28	191.262
#68	STAT5B	23	11	34	3229.703
#69	TFAP2A	23	15	38	581.297
#70	SMAD6	23	9	32	99.04
#71	HCFC1	22	13	35	1162.406
#72	MEF2A	22	12	34	495.704
#73	MEF2C	22	12	34	6472.375
#74	STRN3	22	9	31	1066.025
#75	RB1	22	9	31	1257.843
#76	HLF	21	11	32	3207.903
#77	DLX2	21	3	24	608.34
#78	GCFC1	21	12	33	1994.547
#79	NFYB	21	8	29	5740.736
#80	NR2F1	21	18	39	1370.154
#81	HIF3A	21	9	30	1315.495
#82	NKX2-1	21	11	32	2058.496
#83	SOX15	21	6	27	821.242
#84	ETS2	21	13	34	3288.057
#85	TSC22D1	20	12	32	1152.66
#86	SPDEF	20	15	35	10245.571
#87	ZNF45	20	14	34	3664.173
#88	PAX8	20	9	29	689.261
#89	SOX21	20	5	25	2733.091
#90	TCFL5	20	16	36	1829.536
#91	SPEN	20	0	20	0
#92	NR3C2	20	13	33	7043.064
#93	RERE	20	9	29	597.236
#94	SP3	20	11	31	1468.838
#95	PEG3	20	14	34	8308.389
#96	TRIM22	20	14	34	1938.862
#97	FOXF2	20	12	32	537.659
#98	RELB	19	14	33	1311.26
#99	AFF1	19	10	29	586.894
#100	BTG2	19	11	30	1907.672
#101	NFIB	19	18	37	4995.358
#102	ZNF217	19	8	27	999.229
#103	ARNT	19	9	28	580.254
#104	RBPJ	19	10	29	1160.656
#105	CBFA2T3	19	10	29	135.399
#106	GRHL2	19	12	31	1268.652
#107	RARG	19	8	27	695.64
#108	ZNF148	19	9	28	1185.799
#109	HIF1A	19	13	32	1195.756
#110	FOSB	19	5	24	83.524
#111	RUNX1	18	11	29	953.695
#112	SMAD2	18	8	26	578.583
#113	ATF3	18	2	20	275.09
#114	MEIS2	18	13	31	328.471
#115	ZFPM2	18	8	26	386.978
#116	HDAC2	18	14	32	3820.898
#117	TRIM28	18	21	39	1747.042
#118	CEBPD	18	13	31	2736.066
#119	TSC22D4	18	8	26	1792.425
#120	NR2F2	18	13	31	466.848
#121	NFYA	18	9	27	1502.85
#122	PBX1	18	17	35	845.013
#123	TWIST1	18	16	34	3370.509
#124	BARX1	18	5	23	409.002
#125	ARNTL2	17	12	29	4221.957
#126	SRF	17	17	34	892.28
#127	IRF3	17	13	30	1484.567
#128	E2F5	17	13	30	1072.517
#129	SIM2	17	5	22	99.579
#130	TBX4	17	9	26	115.656
#131	NPAS1	17	9	26	326.171
#132	FEV	17	7	24	181.42
#133	REST	17	7	24	606.382
#134	POU3F1	17	9	26	259.987
#135	IRF8	17	12	29	1015.888
#136	ZNF236	17	6	23	5189.11
#137	NOLC1	17	8	25	387.622
#138	TCF15	16	5	21	76.733
#139	RARA	16	12	28	2723.58
#140	ZHX3	16	10	26	1862.391
#141	STAT6	16	15	31	2507.463
#142	UBP1	16	14	30	4911.809
#143	KLF6	16	8	24	485.738
#144	TP73	16	15	31	2542.46
#145	NFE2L2	16	16	32	2608.291
#146	PLSCR1	16	18	34	2400.154
#147	KLF11	16	12	28	2531.013
#148	HEY1	16	12	28	496.822
#149	FOXO1	16	12	28	513.11
#150	PITX3	16	7	23	878.502
#151	HNF1B	15	9	24	816.047
#152	TP53	15	17	32	3280.589
#153	EDF1	15	15	30	2423.405
#154	FOXK2	15	12	27	297.679
#155	TFCP2	15	10	25	5181.271
#156	SIX1	15	13	28	1280.302
#157	MAFB	15	10	25	2696.797
#158	FOXA1	15	18	33	645.302
#159	RXRA	15	13	28	458.576
#160	HMG20B	15	13	28	2066.516
#161	UBN1	15	7	22	897.632
#162	C11orf9	14	14	28	765.485
#163	TCF4	14	13	27	1025.233
#164	TRIM29	14	12	26	3291.866
#165	BHLHE41	14	10	24	1981.128
#166	ZNF281	14	15	29	960.97
#167	SOX17	14	13	27	4336.63
#168	NFE2L3	14	14	28	3465.814
#169	FOXA2	14	21	35	2104.259
#170	KLF10	14	15	29	428.554
#171	SATB1	14	15	29	1026.863
#172	KDM5A	14	6	20	857.731
#173	CSDA	14	11	25	1162.42
#174	MLL	14	5	19	171.293
#175	FOXO4	14	10	24	891.609
#176	TBX5	14	4	18	1287.141
#177	LHX3	14	8	22	1240.796
#178	E2F6	14	12	26	761.786
#179	CDX2	14	6	20	2413.53
#180	PHF1	14	7	21	570.234
#181	TFEB	14	21	35	1056.535
#182	LASS6	13	17	30	1387.014
#183	NR4A1	13	7	20	970.715
#184	ZNF193	13	14	27	1921.099
#185	ATF1	13	17	30	2775.567
#186	ZNF133	13	10	23	1323.457
#187	NPAS2	13	14	27	2057.146
#188	TAF6	13	12	25	406.299
#189	PITX1	13	14	27	2323.456
#190	PPARG	13	14	27	2395.322
#191	ZXDC	13	8	21	672.053
#192	ZNF167	13	15	28	1438.072
#193	TSC22D3	13	14	27	1693.135
#194	ALX1	13	15	28	2877.781
#195	ZBTB38	13	6	19	155.119
#196	TAF10	13	18	31	908.245
#197	ISL1	13	9	22	2228.48
#198	ETV4	13	13	26	948.656
#199	EN1	13	9	22	2938.075
#200	SLC30A9	13	10	23	889.442
#201	YEATS4	13	16	29	11028.686
#202	SUPT4H1	12	15	27	532.577
#203	GATA3	12	19	31	6224.86
#204	NOTCH1	12	10	22	308.043
#205	ELF3	12	15	27	668.591
#206	CNOT8	12	12	24	332.333
#207	YY1	12	8	20	684.198
#208	NR4A3	12	10	22	1135.593
#209	TFAM	12	13	25	840.27
#210	ELK3	12	16	28	1333.48
#211	GAS7	12	13	25	1578.68
#212	ZNF75D	12	18	30	1875.712
#213	FOXN3	12	13	25	1010.988
#214	TFE3	12	17	29	3987.302
#215	USF2	12	14	26	282.397
#216	HR	12	11	23	639.384
#217	SOX18	12	10	22	784.361
#218	EMX1	12	12	24	610.737
#219	BHLHE40	12	13	25	696.669
#220	RUNX1T1	12	15	27	250.316
#221	ZBTB17	12	13	25	1608.212
#222	SCAND1	12	12	24	850.097
#223	MMP14	12	17	29	1455.463
#224	HHEX	12	11	23	6682.231
#225	ZSCAN16	12	17	29	2944.626
#226	SOX2	12	18	30	2319.297
#227	MYNN	12	13	25	1121.155
#228	ZNF93	12	15	27	571.041
#229	TCF7L2	11	18	29	1408.217
#230	ZNF140	11	13	24	1830.713
#231	TAF12	11	15	26	2109.811
#232	LMX1B	11	11	22	2176.804
#233	CBFA2T2	11	11	22	3287.156
#234	TGIF1	11	18	29	619.362
#235	CREB1	11	9	20	702.805
#236	EVX1	11	5	16	1471.011
#237	RCOR1	11	18	29	858.457
#238	CITED2	11	14	25	3630.883
#239	TAF4	11	11	22	1975.96
#240	IRF1	11	17	28	2267.075
#241	ZGPAT	11	11	22	891.912
#242	TRPS1	11	18	29	2564.927
#243	ELF1	11	5	16	556.763
#244	NR1H2	11	12	23	1596.321
#245	MSRB2	11	13	24	1820.612
#246	NFAT5	11	6	17	473.995
#247	HEY2	11	18	29	1036.401
#248	ZIC1	11	18	29	4873.721
#249	HNRNPAB	11	11	22	1245.364
#250	DDIT3	11	11	22	3141.659
#251	IRX5	10	14	24	959.191
#252	NFIL3	10	9	19	325.679
#253	ETV6	10	15	25	1223.481
#254	HOXA6	10	10	20	465.12
#255	HOXC10	10	11	21	907.441
#256	CREBBP	10	21	31	3575.006
#257	ASCL1	10	8	18	1267.541
#258	E2F1	10	14	24	485.657
#259	PRDM1	10	10	20	235.697
#260	RUNX3	10	8	18	1107.882
#261	CREB3L2	10	18	28	2891.705
#262	SNAI2	10	14	24	1049.987
#263	ATF5	10	17	27	838.788
#264	MAFG	10	16	26	1915.316
#265	CEBPB	10	17	27	2601.326
#266	SLC2A4RG	10	10	20	347.302
#267	HOXD10	10	11	21	5413.791
#268	MEOX2	10	10	20	3906.478
#269	HOXC11	10	10	20	323.65
#270	ECSIT	10	11	21	2013.827
#271	ETV7	10	12	22	891.205
#272	ZFHX4	10	16	26	1763.813
#273	YBX1	9	10	19	337.202
#274	SCML1	9	20	29	1665.148
#275	ATF4	9	16	25	1014.649
#276	VTN	9	15	24	688.691
#277	TCF7	9	12	21	1186.105
#278	CDKN2A	9	18	27	1430.628
#279	ZNF33B	9	10	19	797.105
#280	NFIC	9	13	22	499.332
#281	TCF7L1	9	17	26	821.635
#282	HOXB5	9	15	24	4831.658
#283	MZF1	9	15	24	1434.321
#284	AHR	9	15	24	1192.085
#285	NFKB2	9	20	29	2768.654
#286	JUNB	9	8	17	850.27
#287	TFDP2	9	18	27	241.056
#288	LEF1	9	12	21	556.508
#289	FOS	9	7	16	488.052
#290	ZNF238	9	25	34	3489.442
#291	GABPA	9	13	22	456.786
#292	TEAD3	9	17	26	1355.345
#293	NFYC	9	12	21	1663.611
#294	TFEC	9	13	22	1438.463
#295	ZFP36L1	9	19	28	1589.079
#296	FOXG1	9	8	17	1389.03
#297	HOXD3	9	12	21	445.467
#298	MITF	8	12	20	619.602
#299	TCF25	8	12	20	726.877
#300	ATF6	8	8	16	389.221
#301	PRRX1	8	20	28	1441.759
#302	CREM	8	9	17	1603.103
#303	ZNF91	8	17	25	799.783
#304	BCL6	8	11	19	504.883
#305	NFATC1	8	14	22	1458.396
#306	ZNF24	8	9	17	557.748
#307	IRF9	8	18	26	8451.208
#308	HOXD1	8	24	32	2971.535
#309	AR	8	16	24	244.978
#310	IRF6	8	12	20	1093.663
#311	AHCTF1	8	11	19	733.46
#312	BRD8	8	16	24	983.209
#313	TLX3	8	12	20	1037.616
#314	VAV1	8	19	27	980.107
#315	DLX4	8	12	20	651.577
#316	STAT1	8	15	23	746.887
#317	CSRNP2	8	15	23	1702.655
#318	AATF	8	11	19	445.845
#319	TBP	8	16	24	1159.123
#320	EGR3	8	12	20	2574.66
#321	STAT4	8	12	20	1306.803
#322	ARID3A	8	13	21	2390.07
#323	SNAPC5	8	15	23	1972.828
#324	HCLS1	8	15	23	2105.494
#325	ZNF131	8	19	27	1998.478
#326	ELF4	7	22	29	2319.799
#327	TGIF2	7	14	21	752.166
#328	TCF12	7	15	22	1379.851
#329	MNX1	7	21	28	753.959
#330	HMGA2	7	15	22	2008.438
#331	FOXN1	7	13	20	1330.294
#332	FOSL1	7	16	23	1725.182
#333	GABPB1	7	16	23	1277.884
#334	E4F1	7	13	20	1859.545
#335	KLF7	7	11	18	572.226
#336	HSF1	7	13	20	1028.449
#337	PRDM2	7	8	15	1149.579
#338	MAF	7	8	15	144.525
#339	GTF2H3	7	13	20	1224.332
#340	SPIB	7	13	20	503.624
#341	FOXE1	7	10	17	683.564
#342	CITED1	7	8	15	4112.009
#343	PBX2	7	12	19	301.865
#344	MYCL1	7	12	19	1226.669
#345	TP63	7	13	20	1206.66
#346	FOXD1	7	8	15	1229.949
#347	FOSL2	7	11	18	430.169
#348	ETV5	7	14	21	295.739
#349	MTA1	7	19	26	836.182
#350	ESRRG	7	16	23	1741.667
#351	IRF4	7	10	17	549.391
#352	ZBTB48	7	13	20	1936.213
#353	NR2F6	7	21	28	1686.412
#354	NR0B1	7	20	27	2460.713
#355	PURA	7	14	21	1337.179
#356	RFX5	7	15	22	454.99
#357	TCEAL1	7	14	21	581.688
#358	ZNF274	7	16	23	2853.522
#359	NR4A2	7	8	15	82.026
#360	BCL3	6	17	23	507.722
#361	ZNF277	6	18	24	758.791
#362	JUN	6	12	18	526.785
#363	ZSCAN18	6	19	25	932.025
#364	BACH2	6	11	17	381.828
#365	RORA	6	14	20	505.882
#366	PAX6	6	10	16	622.606
#367	ZNF323	6	18	24	1315.735
#368	NFKB1	6	16	22	1030.552
#369	ST18	6	7	13	677.623
#370	BATF3	6	12	18	1760.355
#371	ERF	6	11	17	312.208
#372	NFATC3	6	16	22	204.297
#373	HOXA4	6	12	18	1450.222
#374	FOXC1	6	16	22	1195.215
#375	SMAD1	6	17	23	1649.712
#376	CTCF	6	14	20	1333.208
#377	SIX2	6	16	22	1059.015
#378	PROX1	6	17	23	1650.903
#379	HOXB2	6	10	16	709.098
#380	AEBP1	6	16	22	1314.996
#381	IRF7	6	19	25	738.39
#382	HOXA10	6	18	24	914.364
#383	NR1H3	6	21	27	2495.064
#384	MLLT10	6	16	22	794.537
#385	SATB2	6	18	24	983.074
#386	LHX6	5	15	20	325.111
#387	ELF2	5	15	20	327.828
#388	TCF20	5	12	17	2810.651
#389	TSC22D2	5	18	23	483.225
#390	ZNF189	5	15	20	750.495
#391	BACH1	5	13	18	448.167
#392	ESR1	5	11	16	1285.681
#393	HOXB7	5	13	18	287.157
#394	BTAF1	5	14	19	997.28
#395	CUX1	5	10	15	521.234
#396	SOX12	5	22	27	541.835
#397	POU4F1	5	8	13	365.378
#398	SREBF2	5	16	21	1572.26
#399	TFCP2L1	5	18	23	947.109
#400	SOX11	5	19	24	1848.375
#401	RBCK1	5	13	18	352.854
#402	SMAD5	5	14	19	1142.315
#403	NCOR1	5	16	21	2221.58
#404	TARDBP	5	22	27	628.288
#405	PA2G4	5	10	15	563.216
#406	FOXJ2	5	12	17	550.628
#407	GTF2I	5	16	21	958.18
#408	MEIS3P1	5	17	22	400.884
#409	XBP1	5	20	25	836.823
#410	PPARD	5	14	19	355.686
#411	VDR	5	11	16	505.386
#412	ZNF83	5	19	24	712.766
#413	TAF7	5	19	24	317.415
#414	ELF5	5	24	29	1102.967
#415	CREB3L1	5	14	19	824.038
#416	RFXANK	4	14	18	786.752
#417	HOXA1	4	23	27	1301.774
#418	WT1	4	12	16	423.597
#419	HIRA	4	14	18	738.818
#420	IRF5	4	14	18	340.021
#421	ADNP2	4	12	16	605.887
#422	GATAD2A	4	13	17	450.078
#423	SPI1	4	15	19	322.295
#424	KLF5	4	24	28	1041.519
#425	GLI3	4	16	20	128.582
#426	HOXD4	4	22	26	1489.37
#427	BCL11B	4	18	22	697.566
#428	CNOT7	4	20	24	1910.815
#429	SMAD3	4	12	16	462.481
#430	HMGB1	4	13	17	348.75
#431	SALL2	4	11	15	382.646
#432	ZNF165	4	20	24	1981.624
#433	CLOCK	4	13	17	2331.387
#434	LASS2	4	14	18	961.725
#435	FOXJ1	4	11	15	328.8
#436	ZFP36L2	4	16	20	1550.406
#437	SOX9	4	26	30	1189.858
#438	MAX	4	17	21	391.274
#439	IRX4	4	20	24	400.593
#440	C2orf3	4	14	18	513.634
#441	MYC	4	14	18	510.429
#442	ARID4A	4	17	21	398.313
#443	SREBF1	4	20	24	1129.011
#444	GATAD1	4	13	17	573.731
#445	CEBPA	4	18	22	349.45
#446	MSC	4	15	19	898.591
#447	HOXD11	4	14	18	5776.328
#448	SOLH	4	16	20	1812.778
#449	DRAP1	4	11	15	523.355
#450	JUND	4	15	19	320.633
#451	PCGF2	3	16	19	425.522
#452	EGR4	3	15	18	703.27
#453	EGR2	3	12	15	1531.548
#454	ZHX2	3	15	18	361.582
#455	TEAD4	3	18	21	138.806
#456	MGA	3	20	23	587.03
#457	ZNF232	3	15	18	164.692
#458	CTNNB1	3	17	20	347.959
#459	LMO4	3	23	26	2654.712
#460	EHF	3	24	27	351.244
#461	NKX3-1	3	15	18	648.085
#462	ZNF117	3	18	21	2038.565
#463	CBFB	3	14	17	84.796
#464	ZNF175	3	11	14	163.684
#465	SP140	3	9	12	468.812
#466	CIR1	3	8	11	145.409
#467	RNF4	3	21	24	468.988
#468	POU4F2	3	8	11	225.164
#469	MEOX1	3	12	15	704.297
#470	ZFHX3	3	19	22	445.485
#471	HOXB6	2	13	15	1241.603
#472	NPAT	2	14	16	189.333
#473	ARNT2	2	17	19	825.547
#474	MYCN	2	10	12	1055.285
#475	CTBP1	2	14	16	108.504
#476	NR5A2	2	15	17	90.475
#477	NR1D2	2	15	17	204.449
#478	MYF5	2	15	17	104.115
#479	PLAG1	2	18	20	999.694
#480	PITX2	2	12	14	927.012
#481	MSX1	1	12	13	92.42
#482	PHTF1	1	19	20	109.099
#483	PLAGL2	1	14	15	307.012
#484	BATF	1	13	14	11.604
#485	ZNF268	1	11	12	57.95
#486	REL	1	17	18	81.198
#487	DMTF1	1	13	14	1057.238
#488	STAT3	1	15	16	577.048
#489	IRF2	1	18	19	185.915
#490	HMBOX1	1	14	15	187.012
#491	FBXW7	1	21	22	52.813
#492	CREB5	1	19	20	277.624
#493	EGR1	1	12	13	22.268
#494	ZKSCAN1	1	17	18	113.001
#495	PBX3	1	14	15	346.807
#496	HOXA9	1	11	12	69.682
#497	ARNTL	0	12	12	0
#498	NFE2	0	15	15	0
#499	WNT5A	0	27	27	0
#500	HES1	0	17	17	0