Hub Rank	Node	Children	Parents	Degree	Betweenness
#1	KDM5B	57	5	62	11259.851
#2	ZHX3	51	3	54	512.285
#3	PBX1	51	6	57	1461.295
#4	MAX	51	10	61	6131.672
#5	IKZF1	50	4	54	147.12
#6	ZNF131	47	4	51	572.876
#7	HOXB3	44	7	51	5817.635
#8	TAF13	43	3	46	97.934
#9	SP3	43	5	48	1343.139
#10	JUN	40	8	48	3097.41
#11	ZBTB17	39	9	48	1879.507
#12	BLZF1	39	2	41	1189.452
#13	TCF3	39	5	44	236.569
#14	SCML2	39	8	47	5493.295
#15	MYBL2	39	4	43	585.462
#16	MAFF	37	4	41	838.769
#17	ZNF219	37	10	47	1141.276
#18	KLF5	36	2	38	32.224
#19	ADNP	36	6	42	3510.305
#20	AFF1	36	4	40	438.764
#21	HOXC4	35	3	38	593.404
#22	ZNF80	35	5	40	1056.882
#23	VDR	34	4	38	907.8
#24	SPDEF	33	6	39	616.33
#25	USF2	33	4	37	750.914
#26	HNF4A	32	14	46	5385.091
#27	ZEB2	32	5	37	604.225
#28	RCAN1	31	6	37	944.947
#29	IRF3	31	13	44	7178.246
#30	KLF6	30	6	36	449.241
#31	ZNF155	30	10	40	5606.824
#32	IRX5	29	8	37	2488.001
#33	NR2F6	29	4	33	259.066
#34	ATF1	29	6	35	2693.065
#35	BATF	28	6	34	1315.337
#36	GATA3	28	7	35	643.977
#37	ZNF217	28	7	35	1185.896
#38	PITX2	27	12	39	1473.373
#39	ZNF444	27	6	33	399.691
#40	NFATC1	27	2	29	108.911
#41	POU1F1	27	9	36	128.644
#42	AATF	26	10	36	2107.463
#43	PTTG1	26	6	32	1586.401
#44	TRPS1	26	7	33	714.599
#45	MEOX2	26	4	30	30.888
#46	ESRRA	25	12	37	2252.833
#47	PURA	25	10	35	2050.232
#48	HMGB2	25	8	33	2681.094
#49	SATB2	25	9	34	9485.724
#50	CITED2	25	11	36	1971.552
#51	NKX3-1	25	6	31	1494.862
#52	PPARA	25	9	34	4903.868
#53	POU6F1	25	14	39	1636.122
#54	ZEB1	24	3	27	3187.447
#55	NFE2L2	24	7	31	1132.092
#56	IRF6	24	7	31	419.473
#57	HMG20B	24	10	34	2615.614
#58	EVX1	24	4	28	922.731
#59	MYC	23	10	33	1414.044
#60	TAF10	23	3	26	181.995
#61	TBX2	23	5	28	444.744
#62	SOX4	22	8	30	2005.291
#63	CTCF	22	8	30	2030.758
#64	FOXO4	22	10	32	1054.647
#65	CBFB	22	9	31	1136.864
#66	KLF10	22	6	28	2663.789
#67	ZNF287	22	7	29	465.349
#68	CEBPE	22	10	32	1412.707
#69	SNAPC5	22	14	36	2772.477
#70	NR2E3	21	7	28	695.81
#71	RBPJ	21	10	31	759.333
#72	PHTF1	21	14	35	3442.48
#73	TFAP2A	21	6	27	525.406
#74	FOXM1	21	4	25	155.393
#75	CUX1	21	10	31	2171.212
#76	LMO4	20	8	28	1702.43
#77	ATF3	20	7	27	2301.584
#78	CNBP	20	6	26	1092.924
#79	WT1	20	13	33	1249.689
#80	NFIB	19	8	27	2166.52
#81	TSC22D2	19	8	27	1814.784
#82	AEBP1	19	7	26	1497.594
#83	CSRNP2	19	12	31	4107.861
#84	XBP1	19	7	26	731.097
#85	TAF5	19	6	25	756.562
#86	TAF7	19	8	27	1623.745
#87	NPAS2	18	8	26	108.629
#88	SMAD2	18	9	27	345.25
#89	TSC22D4	18	9	27	1474.582
#90	CREB3L2	18	11	29	1730.197
#91	POU2F2	18	14	32	4522.551
#92	TCF4	18	8	26	13459.778
#93	HIF1A	18	9	27	1316.033
#94	RELB	18	11	29	2709.083
#95	NPAS1	18	8	26	4000.489
#96	YEATS4	18	6	24	279.495
#97	PITX3	17	11	28	1404.978
#98	HMGB1	17	8	25	726.108
#99	TSC22D1	17	11	28	1088.762
#100	BCL6	17	5	22	174.705
#101	TFAP2C	17	11	28	1000.919
#102	E4F1	17	7	24	1728.477
#103	ZNF202	17	10	27	4184.005
#104	WNT5A	17	10	27	537.29
#105	CSDA	17	12	29	1469.582
#106	AFF4	16	12	28	3601.269
#107	SMAD5	16	13	29	2192.275
#108	NR2F2	16	12	28	913.376
#109	FOS	16	11	27	1098.263
#110	ESR1	16	5	21	408.334
#111	HOXA9	16	9	25	668.319
#112	MEF2A	16	12	28	2075.823
#113	MEF2D	16	14	30	574.346
#114	ZNF24	16	18	34	3571.391
#115	DDIT3	16	8	24	15778.451
#116	ARNT2	16	11	27	2669.509
#117	FOXO1	16	7	23	2815.397
#118	ZNF140	16	9	25	1262.064
#119	IRF9	16	13	29	10098.889
#120	HOXC10	15	13	28	1772.247
#121	GTF2I	15	11	26	1517.696
#122	SCML1	15	13	28	1600.875
#123	E2F8	15	10	25	4118.622
#124	BTG2	15	10	25	1146.577
#125	CREB1	15	9	24	732.411
#126	ARNT	15	10	25	6519.9
#127	CNOT8	15	9	24	1060.471
#128	POU2F3	14	10	24	216.324
#129	HNF1A	14	7	21	332.514
#130	ZNF148	14	11	25	1012.69
#131	NOLC1	14	9	23	641.739
#132	TBX6	14	9	23	184.742
#133	HCFC1	14	11	25	3125.753
#134	NR2C1	14	10	24	472.322
#135	AHCTF1	14	10	24	1085.233
#136	NR4A1	14	11	25	1789.199
#137	DLX2	14	12	26	1074.91
#138	OLIG2	14	10	24	1845.104
#139	GLI2	14	5	19	948.365
#140	SREBF1	14	9	23	931.943
#141	STAT2	14	8	22	885.937
#142	HMGA1	14	6	20	3125.479
#143	EPAS1	14	8	22	462.78
#144	ATF5	14	8	22	848.322
#145	EGR4	13	11	24	1941.807
#146	STRN3	13	16	29	1442.037
#147	KLF4	13	11	24	1097.425
#148	EGR3	13	13	26	2162.008
#149	CREB3L1	13	13	26	2623.867
#150	RXRA	13	17	30	762.149
#151	NFYB	13	14	27	963.596
#152	PCGF2	13	13	26	970.029
#153	PKNOX1	13	15	28	1531.604
#154	E2F6	13	12	25	528.816
#155	HOPX	13	8	21	904.996
#156	CITED1	12	9	21	307.401
#157	ZNF274	12	11	23	4569.88
#158	PBX3	12	11	23	1880.907
#159	NFX1	12	11	23	13631.408
#160	ELF3	12	15	27	1678.931
#161	CTBP1	12	9	21	1003.75
#162	CREBZF	12	12	24	830.304
#163	CBFA2T3	12	9	21	1204.358
#164	ZNF3	12	15	27	2140.124
#165	ARNTL2	12	13	25	2523.704
#166	ZNF189	12	9	21	3510.652
#167	ASCL1	12	15	27	1063.269
#168	ZGPAT	12	12	24	1404.891
#169	MAFG	12	8	20	1192.697
#170	MECOM	12	18	30	1265.303
#171	MLX	12	13	25	1820.527
#172	ZNF91	12	15	27	2935.278
#173	NFATC3	12	10	22	974.477
#174	C11orf9	12	14	26	941.554
#175	HNRNPAB	12	10	22	4388.576
#176	ZNF83	12	13	25	3650.875
#177	FOSL2	11	12	23	1036.929
#178	ESR2	11	13	24	3224.976
#179	UBP1	11	10	21	733.749
#180	SMAD6	11	10	21	1580.405
#181	TCF12	11	11	22	3629.846
#182	ETV7	11	10	21	661.647
#183	HMX1	11	14	25	383.992
#184	RFX5	11	10	21	828.482
#185	ZNF236	11	13	24	1712.841
#186	TBX1	11	10	21	495.914
#187	ZNF268	11	6	17	451.188
#188	ATF6B	11	13	24	2372.479
#189	HOXD13	11	15	26	461.373
#190	SIM1	11	8	19	448.013
#191	LASS2	10	9	19	972.06
#192	RERE	10	10	20	924.888
#193	NR0B1	10	11	21	1801.841
#194	KLF11	10	5	15	744.588
#195	ZNF500	10	14	24	6919.278
#196	ZNF45	10	13	23	1341.399
#197	RUNX1	10	12	22	1983.126
#198	GRHL2	10	8	18	458.764
#199	ZFP36L2	10	13	23	927.232
#200	RELA	10	10	20	988.554
#201	TRIM29	10	7	17	1154.948
#202	CREM	10	7	17	346.273
#203	ZNF232	10	10	20	2110.131
#204	TAF5L	10	12	22	3738.536
#205	NFYA	10	8	18	482.741
#206	ETS2	10	13	23	5846.328
#207	GABPB1	10	13	23	1053.402
#208	TP63	10	14	24	3973.401
#209	KLF9	10	1	11	2.626
#210	TFAP2B	9	12	21	758.788
#211	DLX6	9	6	15	300.181
#212	TCF7L2	9	11	20	740.27
#213	MLL	9	16	25	3997.819
#214	NFATC4	9	11	20	3088.296
#215	ERF	9	8	17	597.28
#216	REL	9	12	21	4088.039
#217	ZHX2	9	9	18	306.381
#218	YY1	9	20	29	4143.277
#219	MYF5	9	15	24	2787.142
#220	ATF4	9	15	24	1414.914
#221	POU4F1	9	12	21	3770.684
#222	ZNF238	9	16	25	1744.817
#223	TEAD3	9	10	19	617.998
#224	TULP4	9	13	22	12168.355
#225	ZSCAN18	9	10	19	2144.856
#226	ETV4	8	11	19	2445.095
#227	ELF5	8	16	24	1016.429
#228	RARG	8	9	17	1590.705
#229	DRAP1	8	12	20	2175.897
#230	SATB1	8	12	20	197.04
#231	PRRX2	8	11	19	961.653
#232	MTA1	8	15	23	549.33
#233	NR5A2	8	13	21	2057.953
#234	NOTCH1	8	13	21	918.343
#235	PLSCR1	8	13	21	479.181
#236	SCAND2	8	10	18	950.108
#237	HES1	8	12	20	1528.693
#238	NKX2-8	8	6	14	2231.868
#239	NFIC	8	6	14	279.304
#240	PITX1	8	9	17	357.669
#241	GTF2IRD1	8	13	21	494.617
#242	SMAD3	8	10	18	420.932
#243	HINFP	8	13	21	1993.95
#244	CREBBP	8	10	18	629.987
#245	ZNF117	8	21	29	3457.835
#246	ZFP37	8	11	19	1271.66
#247	CREB3	8	15	23	1587.859
#248	HOXD9	8	7	15	2257.88
#249	LEF1	7	12	19	5074.586
#250	MSX2	7	12	19	1792.659
#251	HIRA	7	17	24	2248.916
#252	GATA6	7	12	19	1933.874
#253	PHOX2A	7	11	18	1850.6
#254	GLI3	7	15	22	1229.974
#255	MAFK	7	10	17	924.996
#256	TP53	7	11	18	1907.683
#257	NR1H2	7	11	18	778.189
#258	ELF2	7	8	15	1355.87
#259	NFE2L1	7	11	18	1731.017
#260	TRIM28	7	10	17	2447.827
#261	RARA	7	15	22	415.339
#262	TFAP4	7	8	15	642.232
#263	MYNN	7	13	20	1575.117
#264	NR4A3	7	15	22	2722.857
#265	ZNF434	7	12	19	3462.869
#266	HSF2	7	9	16	262.524
#267	KDM5A	7	14	21	5629.642
#268	IRX4	7	8	15	7185.836
#269	ZFP36L1	7	14	21	508.169
#270	ZXDC	7	14	21	3482.09
#271	ZNF263	7	17	24	1533.645
#272	ZNF277	7	14	21	1523.34
#273	MYCN	7	13	20	772.659
#274	TARDBP	7	15	22	1311.099
#275	FOXA1	7	14	21	1434.379
#276	PAX5	7	7	14	794.573
#277	FOXA2	7	8	15	621.445
#278	FOXK2	7	12	19	457.682
#279	JUND	7	10	17	185.939
#280	TAF4	7	13	20	1663.277
#281	STAT4	7	10	17	7782.569
#282	TAF12	7	12	19	1430.94
#283	LZTR1	7	15	22	940.363
#284	MLXIPL	7	16	23	714.453
#285	SREBF2	7	16	23	686.182
#286	GTF2H4	7	11	18	2617.13
#287	E2F2	6	6	12	934.753
#288	ETV5	6	10	16	5127.931
#289	ZSCAN12	6	12	18	1198.337
#290	MMP14	6	10	16	1314.286
#291	KLF12	6	10	16	1535.076
#292	ZKSCAN1	6	16	22	1273.018
#293	SUPT6H	6	13	19	1819.77
#294	GCFC1	6	15	21	1384.547
#295	TBX3	6	11	17	316.94
#296	CEBPB	6	9	15	307.672
#297	TEAD4	6	14	20	2228.934
#298	SLC2A4RG	6	4	10	602.322
#299	BRD8	6	10	16	861.707
#300	STAT3	6	14	20	2391.542
#301	HOXC11	6	11	17	294.975
#302	HHEX	6	11	17	3322.861
#303	TWIST1	6	15	21	2661.978
#304	SUPT4H1	6	10	16	716.305
#305	SRF	6	10	16	325.565
#306	MAF	6	15	21	5476.435
#307	TFAM	6	9	15	1573.256
#308	PGR	6	13	19	554.609
#309	NR2F1	6	11	17	235.728
#310	FOXI1	6	10	16	715.658
#311	ZNF81	6	7	13	207.301
#312	NFYC	6	15	21	2120.907
#313	STAT5B	6	10	16	1156.889
#314	ZNF639	6	12	18	583.664
#315	SCAND1	6	7	13	657.128
#316	NRL	6	11	17	2413.101
#317	POU3F2	6	9	15	272.777
#318	RB1	6	15	21	3858.159
#319	E2F4	6	11	17	1963.379
#320	HEYL	6	10	16	1559.531
#321	SOX10	5	6	11	929.444
#322	E2F5	5	15	20	553.695
#323	PRDM2	5	9	14	1070.972
#324	SOX13	5	15	20	2140.12
#325	ZNF85	5	8	13	2643.093
#326	FOXC1	5	13	18	426.667
#327	ZNF75D	5	14	19	2039.783
#328	MAFB	5	16	21	1097.366
#329	MEIS3P1	5	12	17	255.31
#330	FOXJ3	5	15	20	779.236
#331	TFEB	5	19	24	1231.55
#332	GAS7	5	5	10	660.534
#333	NKX2-5	5	9	14	932.305
#334	TFDP1	5	10	15	261.177
#335	ENO1	5	10	15	518.203
#336	PLAGL2	5	9	14	3811.364
#337	RCOR1	5	14	19	1588.942
#338	CLOCK	5	17	22	1291.733
#339	MYT1	5	14	19	4364.137
#340	MZF1	5	16	21	418.7
#341	STAT6	5	8	13	61.296
#342	HMG20A	5	15	20	1340.004
#343	GATA2	5	13	18	213.957
#344	RXRB	5	13	18	845.754
#345	ZNF207	5	12	17	1088.76
#346	NEUROD2	5	13	18	5687.989
#347	BARX1	5	9	14	256.998
#348	RUNX1T1	5	13	18	239.766
#349	ETV2	5	11	16	293.274
#350	IRF7	5	5	10	729.284
#351	NFKB1	5	13	18	592.38
#352	NR4A2	5	9	14	240.194
#353	SOX9	4	13	17	400.146
#354	ATF6	4	11	15	1598.143
#355	MSX1	4	19	23	447.251
#356	LZTS1	4	9	13	657.059
#357	CTNNB1	4	8	12	212.626
#358	ARNTL	4	8	12	2102.266
#359	TCFL5	4	11	15	305.784
#360	BCL11B	4	16	20	1230.678
#361	TCF25	4	15	19	338.711
#362	HOXB5	4	10	14	2712.199
#363	TADA3	4	17	21	1065.042
#364	BHLHE40	4	12	16	1124.748
#365	GTF2H3	4	17	21	527.397
#366	ZSCAN2	4	13	17	1126.642
#367	NFKB2	4	10	14	355.148
#368	TFDP2	4	9	13	233.068
#369	CEBPD	4	12	16	163.255
#370	TAF6	4	12	16	216.118
#371	PPARD	4	12	16	2477.954
#372	ELK4	4	10	14	560.551
#373	CREBL2	4	16	20	1449.534
#374	RNF4	4	12	16	1952.151
#375	YBX1	4	13	17	169.775
#376	PFDN1	4	13	17	593.247
#377	EDF1	4	11	15	1045.619
#378	HNRNPK	4	12	16	806.055
#379	HOXB7	4	15	19	1346.065
#380	SMAD1	4	19	23	566.537
#381	UBN1	4	15	19	2064.536
#382	CDKN2A	4	7	11	129.266
#383	LASS6	4	15	19	101.617
#384	TFE3	3	14	17	622.704
#385	BACH1	3	16	19	4546.166
#386	KLF3	3	11	14	1009.256
#387	HDAC2	3	14	17	1331.506
#388	CNOT7	3	11	14	517.115
#389	ZNF33B	3	13	16	1633.276
#390	PBX2	3	11	14	416.046
#391	E2F1	3	18	21	995.106
#392	NFE2L3	3	5	8	19.84
#393	ELK1	3	18	21	742.181
#394	ELF1	3	15	18	144.203
#395	BCL3	3	22	25	1201.813
#396	REST	3	14	17	1104.49
#397	ZSCAN16	3	16	19	2024.76
#398	ELK3	3	9	12	213.915
#399	FOXD1	3	11	14	549.998
#400	HSF4	3	9	12	270.172
#401	EMX1	3	12	15	3328.819
#402	HOXC13	3	10	13	391.037
#403	NFIL3	3	12	15	236.69
#404	FOXJ2	3	10	13	647.499
#405	JUNB	3	15	18	1781.918
#406	SOX12	3	12	15	794.403
#407	DBP	3	7	10	100.42
#408	ZNF134	3	10	13	153.722
#409	SNAPC4	3	15	18	180.043
#410	FOXJ1	3	12	15	607.382
#411	MTA2	3	11	14	1154.556
#412	FOXP3	3	8	11	1291.674
#413	SPEN	3	9	12	554.382
#414	ZFHX3	3	15	18	363.71
#415	GABPA	3	8	11	474.85
#416	IRF5	3	7	10	236.879
#417	TGIF1	3	14	17	1877.066
#418	ONECUT2	3	11	14	294.071
#419	POU5F1B	3	12	15	1799.404
#420	HOXC8	3	12	15	832.742
#421	TCF7	3	12	15	375.997
#422	GATAD1	3	9	12	297.434
#423	GBX1	3	4	7	1121.219
#424	FOXO3	3	20	23	153.694
#425	RFXANK	3	10	13	100.963
#426	SCMH1	3	15	18	1315.23
#427	ZKSCAN5	3	14	17	950.317
#428	REXO4	3	13	16	5797.927
#429	GATAD2A	3	18	21	568.668
#430	MTF1	3	16	19	896.245
#431	SLC30A9	2	12	14	140.452
#432	TSC22D3	2	18	20	238.805
#433	BHLHE41	2	12	14	161.892
#434	MSL3	2	20	22	2617.531
#435	TGIF2	2	15	17	1005.846
#436	ECSIT	2	15	17	643.46
#437	BTAF1	2	11	13	152.404
#438	DMTF1	2	13	15	764.531
#439	FUBP1	2	13	15	631.235
#440	STAT1	2	11	13	796.743
#441	HOXC5	2	12	14	106.852
#442	PHF1	2	12	14	164.311
#443	CBFA2T2	2	12	14	932.904
#444	SOX15	2	12	14	386.088
#445	FOXN3	2	13	15	1865.995
#446	C2orf3	2	12	14	2919.877
#447	SNAI2	2	11	13	267.031
#448	SIX3	2	10	12	1521.238
#449	HDAC1	2	10	12	632.663
#450	HSF1	2	7	9	30.961
#451	ZKSCAN4	2	8	10	1592.237
#452	PAX8	2	7	9	106.301
#453	NKX2-1	2	11	13	338.145
#454	PRDM1	2	7	9	3912.727
#455	TBX5	2	12	14	1015.021
#456	MBD1	2	9	11	60.494
#457	KLF7	2	13	15	354.43
#458	VAX2	2	8	10	2023.319
#459	TCF20	2	17	19	2497.681
#460	TCEAL1	1	16	17	612.289
#461	TBX4	1	10	11	58.27
#462	CEBPA	1	17	18	67.474
#463	LHX3	1	12	13	314.115
#464	NCOR1	1	13	14	96.27
#465	HMBOX1	1	13	14	323.358
#466	ZNF93	1	14	15	2613.241
#467	MGA	1	21	22	44.575
#468	ZNF281	1	20	21	66.411
#469	AR	1	12	13	407.319
#470	AHR	1	12	13	49.188
#471	THRA	1	14	15	660.439
#472	TRIM25	1	12	13	1189.303
#473	TCF15	1	7	8	75.518
#474	ZNF174	1	11	12	295.386
#475	NR2C2	1	8	9	57.895
#476	HOXB6	1	12	13	127.705
#477	ZBTB38	1	16	17	419.81
#478	ATF2	1	14	15	105.85
#479	BUD31	1	11	12	224.888
#480	ADNP2	1	12	13	324.766
#481	MSRB2	1	10	11	201.008
#482	ELF4	1	15	16	804.992
#483	MITF	1	9	10	80.219
#484	TAF1B	1	13	14	33.793
#485	ETV1	1	12	13	34.788
#486	HOXA6	1	6	7	299.711
#487	ARID4A	1	10	11	204.918
#488	MNT	1	16	17	1317.139
#489	MNX1	1	15	16	43.761
#490	TBX10	1	11	12	638.363
#491	ZNF35	0	8	8	0
#492	ZNF394	0	22	22	0
#493	CIR1	0	13	13	0
#494	ZNF193	0	8	8	0
#495	E2F3	0	12	12	0
#496	FBXW7	0	13	13	0
#497	SOLH	0	16	16	0
#498	PA2G4	0	16	16	0
#499	RBCK1	0	18	18	0
#500	HEY1	0	12	12	0