Hub Rank	Node	Children	Parents	Degree	Betweenness
#1	ZBTB48	43	9	52	3685.087
#2	BCL6	38	4	42	351.039
#3	KDM5A	37	2	39	114.045
#4	ZNF207	35	0	35	0
#5	ENO1	34	2	36	549.425
#6	GCFC1	33	3	36	120.342
#7	IRX2	32	6	38	3592.623
#8	GAS7	30	7	37	2934.416
#9	KLF16	30	5	35	470.161
#10	KLF9	29	9	38	2140.596
#11	TGIF1	27	7	34	737.585
#12	STRN3	27	10	37	464.598
#13	SMAD5	26	4	30	1429.691
#14	SPI1	25	6	31	1444.176
#15	SIX5	24	7	31	1939.086
#16	MAX	24	6	30	303.449
#17	IRF6	23	10	33	1698.475
#18	SLC2A4RG	23	12	35	1250.025
#19	CSRNP1	23	0	23	0
#20	ELF3	23	9	32	3394.195
#21	MEIS3	23	10	33	910.454
#22	EBF1	22	8	30	1175.318
#23	C5orf41	22	1	23	734.385
#24	SNAPC4	22	12	34	5170.098
#25	HSF1	22	9	31	810.175
#26	HCFC1	21	8	29	1590.38
#27	ZNF643	21	6	27	2175.714
#28	ZFP36L2	21	8	29	1258.4
#29	ZNF445	21	10	31	1584.722
#30	EPAS1	21	8	29	901.102
#31	HNF4A	20	6	26	985.817
#32	STAT1	20	6	26	348.418
#33	SPDEF	20	9	29	2866.53
#34	MZF1	20	10	30	1566.211
#35	NFIB	20	3	23	244.01
#36	ZFP36L1	20	3	23	87.671
#37	AHCTF1	20	13	33	1210.351
#38	ZNF135	20	8	28	1088.963
#39	MAFF	20	4	24	1587.037
#40	PEG3	20	13	33	2697.944
#41	SPEN	20	7	27	309.372
#42	CSDA	19	11	30	1720.066
#43	TFEB	19	8	27	541.278
#44	NR6A1	19	5	24	978.598
#45	SP1	19	7	26	847.958
#46	ETS1	19	8	27	800.208
#47	ZNF500	19	5	24	2689.166
#48	RBPJ	19	9	28	1310.577
#49	UBP1	18	3	21	822.606
#50	SCRT1	18	11	29	3330.613
#51	NR4A3	18	2	20	39.552
#52	CREB3L3	18	10	28	2330.824
#53	FOXA2	18	6	24	1809.387
#54	PHF1	18	12	30	915.066
#55	SMAD4	18	11	29	2157.225
#56	CTNNB1	18	9	27	771.461
#57	BTG2	18	6	24	358.3
#58	REL	18	13	31	1376.204
#59	NR2F6	18	11	29	1086.775
#60	ZGLP1	18	8	26	3032.075
#61	TBX5	18	8	26	858.176
#62	MITF	18	8	26	1566.182
#63	TULP4	17	6	23	621.725
#64	MLXIPL	17	17	34	5066.39
#65	FOXO3	17	10	27	1340.192
#66	ZSCAN18	17	5	22	602.718
#67	POU4F2	17	9	26	2679.737
#68	ETV5	17	8	25	1146.568
#69	SMAD2	17	12	29	547.583
#70	ATF2	17	13	30	2328.421
#71	HOXA1	17	11	28	2046.711
#72	BHLHE40	17	4	21	129.619
#73	SMAD1	17	7	24	913.707
#74	SOX2	16	8	24	681.728
#75	PITX2	16	9	25	2480.09
#76	RERE	16	11	27	1660.202
#77	PROX1	16	8	24	1017.374
#78	MYCN	16	9	25	1424.257
#79	SCAND2	15	5	20	585.938
#80	GATA4	15	14	29	2845.734
#81	SATB2	15	8	23	1740.088
#82	ATF3	15	10	25	982.572
#83	ETV4	15	7	22	435.633
#84	BUD31	15	6	21	653.312
#85	MEF2D	15	10	25	2432.64
#86	LHX4	15	13	28	2658.926
#87	TBX3	15	10	25	1925.225
#88	TFAP2A	15	11	26	1812.96
#89	ZNF446	15	10	25	1470.959
#90	C2orf3	15	9	24	1065.908
#91	RAX2	15	6	21	1715.793
#92	NR3C1	15	6	21	1026.25
#93	FOXA3	15	9	24	822.904
#94	KLF4	14	3	17	451.267
#95	MMP14	14	11	25	702.013
#96	C11orf9	14	15	29	2262.565
#97	RARA	14	16	30	2610.588
#98	IRX4	14	10	24	1045.403
#99	ZNF157	14	7	21	1572.021
#100	PBX1	14	14	28	1818.287
#101	C12orf28	14	12	26	1649.847
#102	NFIA	14	7	21	1106.09
#103	DLX6	14	12	26	1836.264
#104	TFEC	14	8	22	1167.373
#105	MAFG	14	8	22	508.623
#106	NR1D2	14	10	24	2739.208
#107	ISL1	14	4	18	626.508
#108	SOX6	14	7	21	1030.897
#109	PLSCR1	14	12	26	2223.298
#110	NFKB2	14	9	23	1107.915
#111	TFAP2B	13	10	23	891.44
#112	SALL1	13	12	25	2767.229
#113	FOSB	13	6	19	2172.585
#114	NR1H4	13	12	25	1648.98
#115	POU2F1	13	14	27	2281.381
#116	BCL11B	13	11	24	1301.021
#117	ZKSCAN3	13	13	26	1933.36
#118	TSC22D2	13	14	27	2021.502
#119	FOXO1	13	14	27	1691.168
#120	FOXM1	13	7	20	795.291
#121	NRL	13	6	19	1032.231
#122	CTBP1	13	7	20	1599.791
#123	SP3	13	9	22	3543.464
#124	MAFK	13	7	20	591.064
#125	HOXA11	13	13	26	2051.468
#126	POU6F1	13	9	22	846.248
#127	JUN	13	5	18	264.632
#128	FOSL2	13	10	23	392.02
#129	ZNF41	13	9	22	1184.896
#130	SOX10	13	8	21	1304.513
#131	SNAI3	13	10	23	1325.938
#132	VDR	13	9	22	2125.168
#133	ZNF71	13	10	23	1254.114
#134	TFAP2D	13	7	20	1147.71
#135	TAL1	13	7	20	779.457
#136	RUNX3	13	6	19	668.259
#137	HOXC11	13	11	24	992.892
#138	HR	12	13	25	848.827
#139	CCRN4L	12	13	25	1124.602
#140	MYT1L	12	14	26	1189.265
#141	DMRT2	12	7	19	1058.163
#142	ONECUT2	12	13	25	1679.337
#143	AFF4	12	13	25	1325.202
#144	JUNB	12	5	17	456.766
#145	ZNF165	12	10	22	1127.564
#146	PDX1	12	9	21	578.966
#147	TLX2	12	11	23	976.28
#148	ZNF117	12	7	19	1049.543
#149	NR2E1	12	8	20	995.131
#150	ZNF81	12	11	23	1429.837
#151	ZNF215	12	10	22	1297.986
#152	GATA1	12	8	20	2030.169
#153	ZNF3	12	10	22	1507.705
#154	SUPT6H	12	11	23	1299.523
#155	TBX6	12	10	22	1279.42
#156	TP73	12	10	22	1039.482
#157	CEBPB	12	10	22	392.514
#158	POU3F3	12	8	20	1139.033
#159	PAX7	12	8	20	715.612
#160	POU4F1	12	9	21	1723.54
#161	CBFA2T2	12	10	22	1417.101
#162	SLC26A3	12	12	24	1604.121
#163	ESRRB	12	10	22	1552.78
#164	TCF12	12	10	22	968.514
#165	ESX1	12	10	22	1612.261
#166	EGR4	11	13	24	1203.699
#167	SOX12	11	10	21	1254.172
#168	SOX15	11	9	20	1295.124
#169	GRHL3	11	8	19	1466.312
#170	NFATC1	11	9	20	2520.583
#171	ZNF202	11	9	20	1246.493
#172	ANKRD30A	11	14	25	1130.302
#173	NOTCH1	11	9	20	827.662
#174	FOXD3	11	14	25	1448.528
#175	ZNF219	11	10	21	1062.471
#176	NFYA	11	8	19	1400.131
#177	POU2F2	11	11	22	1999.435
#178	PTH	11	12	23	1542.199
#179	TCF4	11	4	15	225.463
#180	HNF4G	11	7	18	1022.504
#181	PGR	11	12	23	1657.041
#182	ZNF483	11	9	20	2398.537
#183	NR5A1	11	11	22	1643.288
#184	ZNF444	11	13	24	2804.223
#185	TADA3	11	15	26	3436.331
#186	ZSCAN4	11	11	22	1176.057
#187	TFDP1	11	12	23	1036.515
#188	EMX1	11	9	20	1073.793
#189	FOS	11	5	16	662.615
#190	HMG20B	11	7	18	649.632
#191	KLF6	11	5	16	186.552
#192	ZIC5	11	11	22	2044.364
#193	FOXE3	11	6	17	1677.621
#194	BCL3	11	12	23	491.867
#195	ISL2	11	12	23	1569.283
#196	TFAP4	11	11	22	1196.559
#197	NR4A2	11	8	19	311.39
#198	FOXK2	11	11	22	1107.255
#199	GSX1	10	18	28	2178.602
#200	TRIM29	10	9	19	1107.616
#201	E2F8	10	12	22	1710.095
#202	EVX1	10	10	20	1305.866
#203	ZNF92	10	10	20	803.288
#204	RB1	10	10	20	422.205
#205	TADA2A	10	7	17	651.609
#206	VENTX	10	10	20	1282.677
#207	ETV1	10	6	16	165.571
#208	HOXD1	10	12	22	1313.506
#209	PITX1	10	9	19	1328.723
#210	EHF	10	13	23	2365.635
#211	LHX9	10	15	25	1305.975
#212	GATA3	10	8	18	1053.019
#213	ELF4	10	8	18	195.445
#214	GCM1	10	7	17	1651.575
#215	LEF1	10	7	17	831.46
#216	HOXC12	10	11	21	726.577
#217	ZIC3	10	10	20	1243.439
#218	FOXD1	10	12	22	1393.426
#219	HOXC8	10	8	18	1266.99
#220	TFE3	10	13	23	1010.195
#221	ELK4	10	12	22	1738.43
#222	CREBBP	10	8	18	561.854
#223	MYNN	10	8	18	528.568
#224	GLI2	10	12	22	1954.896
#225	RBPJL	10	9	19	980.06
#226	MYCL1	10	13	23	751.051
#227	ETV6	10	10	20	465.406
#228	POU3F1	10	12	22	1356.378
#229	FOXK1	10	13	23	942.056
#230	MEOX2	10	9	19	769.068
#231	ZNF396	10	10	20	1778.588
#232	PAX4	10	8	18	695.063
#233	FOXI1	10	8	18	773.192
#234	IKZF1	10	10	20	627.575
#235	SOX21	10	12	22	1918.561
#236	POU1F1	10	14	24	1331.806
#237	IKZF3	10	14	24	1309.858
#238	ATOH1	10	10	20	839.832
#239	MYF5	10	9	19	1412.122
#240	NR5A2	10	13	23	1278.451
#241	EN1	10	7	17	622.632
#242	LMX1B	10	9	19	1835.689
#243	POU4F3	10	14	24	1893.109
#244	OVOL1	10	12	22	1513.314
#245	ONECUT1	9	9	18	1919.916
#246	NPAT	9	7	16	611.804
#247	HOXD9	9	12	21	893.355
#248	SMAD6	9	10	19	1456.488
#249	HIC1	9	9	18	1028.976
#250	MSX2	9	10	19	1552.731
#251	EGR1	9	8	17	469.292
#252	SMAD3	9	11	20	1038.368
#253	RXRB	9	10	19	606.144
#254	SMAD9	9	13	22	1889.965
#255	PRDM2	9	14	23	930.036
#256	E2F2	9	8	17	746.756
#257	HES6	9	8	17	561.678
#258	PPARD	9	10	19	883.471
#259	TCF7L2	9	5	14	333.588
#260	NEUROD1	9	13	22	1061.87
#261	NFATC4	9	12	21	1453.57
#262	LZTS1	9	10	19	873.726
#263	CEBPE	9	10	19	1074.568
#264	SIN3A	9	8	17	740.228
#265	THRB	9	13	22	801.412
#266	HEY2	9	11	20	787.536
#267	HMGA1	9	15	24	1889.092
#268	HOXD3	9	13	22	1974.672
#269	KLF15	9	8	17	831.455
#270	JUND	9	11	20	1179.795
#271	ZSCAN1	9	11	20	767.543
#272	TBX22	9	14	23	1187.864
#273	NFE2L2	9	10	19	503.153
#274	DMBX1	9	12	21	1724.199
#275	POU2F3	9	15	24	1546.307
#276	ST18	9	10	19	1145.565
#277	MEOX1	9	13	22	1359.642
#278	HOXB1	9	10	19	960.633
#279	ZNF238	9	12	21	988.119
#280	SP140	9	9	18	622.183
#281	EGR3	8	7	15	247.854
#282	ASCL2	8	13	21	1223.801
#283	TEAD2	8	18	26	1377.814
#284	NR4A1	8	6	14	397.476
#285	BHLHE41	8	11	19	648.131
#286	RFXAP	8	10	18	681.97
#287	SIX3	8	12	20	1824.326
#288	DLX2	8	10	18	1737.327
#289	TFCP2L1	8	12	20	1675.934
#290	PAX8	8	10	18	657.824
#291	KLF2	8	12	20	802.291
#292	ELF5	8	11	19	745.303
#293	HOXB3	8	11	19	967.995
#294	ZRANB2	8	7	15	511.824
#295	CDKN2A	8	8	16	686.496
#296	CITED1	8	12	20	1036.983
#297	THRA	8	14	22	319.595
#298	FOXE1	8	9	17	522.522
#299	TSC22D1	8	12	20	1205.517
#300	ZFP42	8	12	20	1261.347
#301	NFIC	8	7	15	358.536
#302	NKX3-2	8	10	18	942.705
#303	SIX4	8	10	18	1006.65
#304	HOXB8	8	13	21	891.364
#305	BARX1	8	10	18	983.743
#306	ASCL1	8	12	20	922.666
#307	PURB	8	8	16	1444.837
#308	CRX	8	11	19	1826.31
#309	SCAND1	8	12	20	787.523
#310	VSX1	8	15	23	1093.726
#311	VTN	8	6	14	423.301
#312	ZSCAN2	8	10	18	905.368
#313	MYF6	8	9	17	1595.287
#314	SPIC	8	12	20	1722.223
#315	MYC	8	11	19	1002.521
#316	KLF12	8	14	22	1594.247
#317	SNAPC5	8	14	22	1095.343
#318	SOX5	8	14	22	552.342
#319	TFDP3	8	11	19	1286.557
#320	HOXA13	8	13	21	1804.485
#321	TP63	8	13	21	720.11
#322	MLLT10	8	5	13	388.657
#323	FOXP2	8	12	20	1478.228
#324	FOXJ2	8	10	18	1774.522
#325	MNX1	8	4	12	412.681
#326	POU6F2	7	11	18	1138.672
#327	ZEB2	7	14	21	1218.148
#328	DLX4	7	14	21	1710.784
#329	GBX2	7	9	16	726.685
#330	POU3F4	7	18	25	2264.77
#331	SEBOX	7	11	18	921.421
#332	LASS5	7	11	18	902.697
#333	TBR1	7	15	22	1178.349
#334	MKX	7	15	22	1983.418
#335	TCF15	7	9	16	327.447
#336	FOXJ1	7	16	23	1958.753
#337	ZNF287	7	10	17	746.278
#338	HOXA9	7	13	20	934.38
#339	TBX1	7	12	19	663.733
#340	KLF1	7	10	17	736.716
#341	RCAN1	7	10	17	317.595
#342	SOX30	7	14	21	1057.519
#343	YY1	7	18	25	899.9
#344	SIX2	7	7	14	503.898
#345	BRD8	7	12	19	1273.988
#346	GATA5	7	17	24	1411.957
#347	SIX6	7	13	20	1144.531
#348	TCF20	7	13	20	1506.967
#349	RFX3	7	13	20	1002.869
#350	MXD1	7	13	20	1104.226
#351	FOXN4	7	8	15	370.45
#352	MYBL2	7	10	17	757.78
#353	LHX1	7	14	21	1344.554
#354	WT1	7	12	19	1179.495
#355	ZNF496	7	11	18	1019.294
#356	FOXD4	7	9	16	905.419
#357	ZNF19	7	9	16	1041.317
#358	PAX3	7	15	22	1947.101
#359	HMX1	7	8	15	907.167
#360	SOX1	7	13	20	727.148
#361	ZNF397	7	13	20	1969.006
#362	TRERF1	7	9	16	1054.268
#363	ZFHX3	7	10	17	523.523
#364	TLX3	7	9	16	1654.521
#365	LHX2	7	12	19	2188.32
#366	TSC22D3	7	10	17	1191.538
#367	ZIC2	7	8	15	778.037
#368	HMGA2	7	13	20	1364.064
#369	OLIG2	7	10	17	814.763
#370	MIXL1	7	11	18	1373.64
#371	TCF7	7	11	18	622.645
#372	CSRNP3	6	15	21	1300.011
#373	ARX	6	12	18	837.186
#374	HOXC9	6	13	19	1185.753
#375	HOXD4	6	12	18	968.195
#376	SPIB	6	13	19	798.153
#377	HOXC5	6	8	14	1496.442
#378	ZNF90	6	12	18	962.019
#379	CREB3L1	6	11	17	858.639
#380	HOXB6	6	11	17	863.442
#381	NR2E3	6	12	18	1024.239
#382	HOXA10	6	10	16	818.385
#383	DLX3	6	8	14	333.676
#384	NKX2-3	6	9	15	1344.734
#385	ERF	6	11	17	508.593
#386	CREM	6	8	14	360.661
#387	NR0B1	6	13	19	651.558
#388	PBX3	6	14	20	748.071
#389	TBX20	6	12	18	1077.699
#390	SP4	6	10	16	514.238
#391	SOX4	6	15	21	817.508
#392	SRY	6	15	21	951.43
#393	ZNF167	6	12	18	941.75
#394	BNC1	6	14	20	928.884
#395	ZFHX2	6	12	18	1186.363
#396	RUNX1	6	11	17	660.521
#397	DMRT1	6	11	17	708.869
#398	SIM1	6	17	23	1488.577
#399	OTX2	6	17	23	757.16
#400	MAF	6	14	20	1038.655
#401	ZNF93	6	15	21	1780.74
#402	ZNF80	6	13	19	1304.748
#403	ATF7	6	11	17	995.909
#404	ZNF154	6	14	20	868.93
#405	HMGB2	6	15	21	1382.362
#406	GSC2	6	9	15	673.01
#407	NPAS1	6	14	20	821.008
#408	FOXC2	6	11	17	481.014
#409	HSF5	6	10	16	512.305
#410	TBX2	6	15	21	868.619
#411	ZNF174	6	11	17	818.353
#412	FOXG1	6	9	15	785.073
#413	NFATC2	6	12	18	448.405
#414	PHOX2B	5	7	12	754.34
#415	PPARA	5	10	15	920.118
#416	FUBP1	5	14	19	896.094
#417	FOSL1	5	9	14	261.126
#418	LMX1A	5	15	20	586.572
#419	MESP1	5	17	22	939.277
#420	ESR2	5	9	14	434.957
#421	GSX2	5	14	19	1148.416
#422	KLF17	5	11	16	691.429
#423	CUX2	5	11	16	746.107
#424	RORA	5	17	22	1762.484
#425	HIRA	5	11	16	685.148
#426	GLI3	5	11	16	460.223
#427	TEAD1	5	14	19	1506.217
#428	FOXL1	5	17	22	741.422
#429	ZSCAN23	5	11	16	443.057
#430	ELK1	5	13	18	579.771
#431	TCF3	5	12	17	825.497
#432	MGA	5	8	13	341.37
#433	HESX1	5	11	16	1095.178
#434	AFF1	5	19	24	714.753
#435	FOXB1	5	10	15	525.544
#436	NKX2-8	5	13	18	426.376
#437	ESR1	5	10	15	1200.756
#438	RUNX1T1	5	14	19	689.332
#439	GATAD2A	5	15	20	505.901
#440	TSHZ2	5	9	14	630.615
#441	IRF4	5	8	13	508.188
#442	ZSCAN12	5	16	21	652.55
#443	FOXH1	5	7	12	383.003
#444	HOPX	5	12	17	459.55
#445	TEF	5	21	26	1263.831
#446	NFAT5	5	12	17	1990.93
#447	RARB	5	9	14	832.342
#448	ZNF85	5	8	13	448.684
#449	USF1	5	11	16	381.869
#450	POU3F2	5	12	17	925.957
#451	RORB	4	13	17	1021.39
#452	FOXD2	4	12	16	627.114
#453	NR1I2	4	11	15	361.554
#454	HOXB7	4	9	13	884.629
#455	KDM5B	4	15	19	757.002
#456	NKX6-1	4	16	20	835.28
#457	ATF5	4	12	16	804.985
#458	ISX	4	8	12	506.204
#459	BLZF1	4	12	16	463.718
#460	NKX6-2	4	7	11	192.227
#461	ZFHX4	4	16	20	1063.814
#462	HIF3A	4	13	17	794.65
#463	HNF1A	4	14	18	761.452
#464	SIM2	4	12	16	352.147
#465	NOBOX	4	10	14	630.621
#466	FOXN3	4	13	17	670.789
#467	NCOR1	4	14	18	991.614
#468	HNRNPAB	4	13	17	375.986
#469	EN2	4	14	18	874.001
#470	DLX1	4	15	19	1090.474
#471	POU5F2	4	15	19	1047.235
#472	SIX1	4	10	14	475.768
#473	FOXP3	4	13	17	625.731
#474	TAF13	4	18	22	898.182
#475	CREBZF	4	15	19	709.746
#476	HES5	4	11	15	579.722
#477	NFIX	4	13	17	362.693
#478	FOXR2	3	12	15	386.776
#479	NFE2	3	13	16	909.564
#480	RUNX2	3	13	16	482.054
#481	MLL	3	10	13	286.12
#482	KCNH8	3	12	15	531.174
#483	FLI1	3	15	18	1410.1
#484	SOX11	3	13	16	489.482
#485	TFAP2C	3	12	15	634.159
#486	HOXD11	3	14	17	838.805
#487	FOXL2	2	12	14	324.581
#488	ARNTL2	2	10	12	178.248
#489	REST	2	15	17	458.529
#490	ZIC1	2	17	19	490.362
#491	ZNF131	2	12	14	245.606
#492	ZSCAN20	2	15	17	205.089
#493	LHX8	2	17	19	480.767
#494	HOXD13	2	12	14	308.05
#495	NKX2-5	2	11	13	323.405
#496	NR1I3	2	13	15	132.873
#497	ARNT	2	15	17	245.372
#498	RARG	2	9	11	192.007
#499	PAX6	1	15	16	104.085
#500	HOXA2	1	10	11	72.943