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Hub Rank	Node	Children	Parents	Degree	Betweenness
#1	MMP14	66	1	67	66.489
#2	CSRNP2	60	5	65	877.703
#3	HMGB1	57	1	58	26.849
#4	TEAD3	56	4	60	591.826
#5	ZBTB48	53	3	56	313.924
#6	ZNF157	52	6	58	341.434
#7	TCF15	52	3	55	131.686
#8	HIC1	49	6	55	1952.371
#9	ZNF263	48	5	53	405.735
#10	TFAM	48	4	52	144.013
#11	SOX10	47	5	52	848.789
#12	SMAD5	46	4	50	214.53
#13	RELA	46	7	53	473.474
#14	ATF6	42	6	48	344.988
#15	CEBPA	41	14	55	1723.891
#16	ZNF3	41	11	52	1601.294
#17	ARNT	41	11	52	1661.964
#18	SMAD4	40	6	46	345.685
#19	SIX6	39	7	46	993.266
#20	SPIB	39	8	47	1305.117
#21	HMGA1	39	5	44	746.254
#22	CREB3L2	39	6	45	380.158
#23	FLI1	38	2	40	373.289
#24	TAF4	38	7	45	951.916
#25	PHF1	38	9	47	602.738
#26	ZNF24	38	11	49	738.617
#27	ATF3	37	5	42	393.296
#28	BHLHE40	37	8	45	695.566
#29	CITED1	37	6	43	2783.851
#30	BRD8	37	16	53	2392.701
#31	FOSL2	37	7	44	1311.722
#32	ESRRA	37	9	46	1774.409
#33	HOXB13	37	10	47	1404.292
#34	MYBL2	36	8	44	1755.005
#35	HOXC4	36	8	44	521.757
#36	ZNF134	36	15	51	1801.379
#37	SMAD2	35	5	40	885.689
#38	NFYA	35	12	47	1686.603
#39	SNAPC4	35	9	44	974.179
#40	CITED2	35	5	40	814.501
#41	FOXO1	34	7	41	1000.178
#42	ARNT2	34	15	49	2144.947
#43	BCL3	34	12	46	1848.684
#44	MEIS3P1	34	9	43	1457.117
#45	ATF2	34	11	45	1188.654
#46	CDKN2A	33	13	46	1975.513
#47	ZNF80	33	3	36	637.983
#48	ZNF45	33	11	44	984.417
#49	NPAT	33	13	46	1063.159
#50	NFE2	32	11	43	1243.2
#51	HOXB7	32	7	39	925.495
#52	FOXO4	32	13	45	1485.358
#53	RBCK1	32	15	47	879.769
#54	CREBZF	31	13	44	890.193
#55	HIRA	31	7	38	794.647
#56	ESR2	31	14	45	1258.113
#57	NFKB1	30	11	41	1244.617
#58	TEF	30	16	46	2445.742
#59	NR2C1	30	16	46	2269.632
#60	TAF7	30	10	40	2201.943
#61	MYC	30	14	44	2229.111
#62	GATAD1	30	8	38	1094.656
#63	MEF2C	30	4	34	239.353
#64	VENTX	30	9	39	1383.222
#65	SOX15	29	9	38	774.73
#66	ISL1	29	11	40	1278.113
#67	FOXC2	29	7	36	1329.844
#68	CSDA	29	13	42	1152.688
#69	SNAPC2	28	17	45	3420.604
#70	ELF1	28	4	32	130.612
#71	BLZF1	28	8	36	519.217
#72	KDM5B	28	16	44	2046.632
#73	MYOG	28	9	37	1243.531
#74	JUN	27	9	36	402.099
#75	KLF6	27	12	39	758.786
#76	TP63	27	11	38	619.739
#77	TSC22D2	27	10	37	834.55
#78	TLX2	27	16	43	1881.401
#79	TFAP4	27	11	38	856.123
#80	PBX1	27	14	41	839.796
#81	FEV	26	22	48	2423.156
#82	ZNF238	26	20	46	2065.724
#83	TLX1	26	17	43	3130.425
#84	NFE2L2	26	11	37	967.398
#85	TRIM29	26	14	40	3015.901
#86	OVOL1	26	13	39	1175.643
#87	SNAPC5	26	15	41	1582.698
#88	ELK3	26	9	35	504.328
#89	RERE	26	18	44	1542.656
#90	HMGB2	25	12	37	1657.103
#91	PPARD	25	16	41	595.706
#92	TAF4B	25	11	36	879.973
#93	MAX	25	14	39	925.965
#94	PAX5	25	8	33	1020.973
#95	NR1D2	25	3	28	55.351
#96	CREB3L1	24	12	36	1597.599
#97	TBX2	24	16	40	1031.002
#98	ZNF148	24	10	34	279.559
#99	CEBPB	24	2	26	143.638
#100	LMO4	23	18	41	1844.021
#101	AHR	23	13	36	2136.811
#102	RB1	23	11	34	809.927
#103	VDR	23	17	40	1880.733
#104	ZNF35	23	12	35	617.413
#105	ZNF217	23	15	38	1290.158
#106	THRA	22	19	41	2786.654
#107	DDIT3	22	13	35	861.295
#108	FUBP1	22	15	37	1019.566
#109	HSF2	22	13	35	678.749
#110	POU3F2	22	9	31	292.296
#111	KLF10	22	16	38	874.002
#112	CEBPD	22	6	28	567.756
#113	RELB	22	4	26	394.76
#114	TGIF2	22	16	38	801.347
#115	TFCP2	22	19	41	1201.578
#116	SMAD3	22	20	42	2687.732
#117	STAT2	22	15	37	1191.822
#118	MEF2A	21	7	28	328.767
#119	TCEAL1	21	16	37	913.746
#120	TCF4	21	15	36	1129.062
#121	CDX2	21	14	35	1295.309
#122	FOXN3	21	16	37	1243.753
#123	SOLH	21	15	36	1231.973
#124	NFATC1	21	11	32	680.757
#125	IRF5	21	16	37	983.91
#126	SPDEF	21	15	36	1277.677
#127	SIX3	21	9	30	479.558
#128	IRF8	20	14	34	1768.196
#129	NFIL3	20	15	35	559.662
#130	TSC22D3	20	7	27	345.716
#131	SOX2	20	15	35	1335.641
#132	RUNX3	20	10	30	768.207
#133	MTA1	20	12	32	561.57
#134	IRF1	20	13	33	745.825
#135	PPARA	20	12	32	1468.565
#136	NFATC3	20	12	32	758.841
#137	GATA4	20	16	36	1044.035
#138	GATA1	20	19	39	1045.434
#139	NFKB2	20	10	30	391.141
#140	LEF1	20	14	34	1088.424
#141	HOXD8	20	11	31	1305.407
#142	ASCL1	20	11	31	637.377
#143	STAT3	20	13	33	1686.382
#144	RARB	20	13	33	1110.418
#145	MITF	20	20	40	1887.513
#146	E2F6	20	18	38	903.284
#147	ZNF117	20	11	31	929.639
#148	TWIST1	20	15	35	1298.579
#149	PLSCR1	19	14	33	491.657
#150	ZNF165	19	16	35	1419.664
#151	HIF1A	19	25	44	2009.266
#152	STAT6	19	13	32	1275.325
#153	CRX	19	18	37	687.225
#154	FOSB	19	11	30	336.189
#155	CBFA2T3	19	19	38	2714.676
#156	MXD1	19	13	32	945.112
#157	IRF4	19	16	35	1335.977
#158	IRF2	19	14	33	686.497
#159	MEF2D	19	16	35	775.937
#160	CUX1	19	13	32	660.145
#161	NFIC	19	12	31	1681.965
#162	IRF7	19	5	24	159.572
#163	HOXA10	18	17	35	838.236
#164	GABPB1	18	17	35	1127.577
#165	NR3C1	18	14	32	666.968
#166	ESRRG	18	14	32	875.122
#167	HR	18	21	39	1956.787
#168	ZFP36L2	18	12	30	604.624
#169	DBP	18	16	34	1693.22
#170	TP53	18	13	31	1812.972
#171	IKZF1	18	8	26	701.909
#172	SP1	18	16	34	1042.046
#173	TFAP2A	18	15	33	1246.92
#174	ETV2	18	24	42	2235.839
#175	SALL2	18	19	37	1297.949
#176	FOXI1	18	17	35	1371.918
#177	FOXD2	18	16	34	1185.234
#178	C2orf3	17	14	31	642.141
#179	PRRX1	17	24	41	1237.888
#180	MAFF	17	21	38	1518.778
#181	ZEB1	17	17	34	1513.984
#182	DLX4	17	20	37	897.483
#183	LZTR1	17	22	39	1189.863
#184	ZKSCAN4	17	17	34	1468.235
#185	ADNP2	17	15	32	872.842
#186	SATB2	17	23	40	1200.706
#187	ZNF175	17	17	34	818.794
#188	VAV1	16	22	38	1083.544
#189	FOXD1	16	17	33	1566.216
#190	POU2F2	16	17	33	1056.899
#191	REST	16	13	29	428.339
#192	GCM1	16	19	35	1165.639
#193	RFX1	16	15	31	1701.663
#194	TFDP1	16	16	32	763.673
#195	ERF	16	19	35	1075.701
#196	ZFP36L1	16	19	35	520.039
#197	ZNF91	16	10	26	887.663
#198	AHCTF1	16	14	30	873.438
#199	CNOT8	16	13	29	889.795
#200	ELF3	16	16	32	1284.638
#201	PBX3	16	17	33	1084.736
#202	PHTF1	16	17	33	707.645
#203	ZNF274	16	17	33	2042.319
#204	FOXM1	16	10	26	619.742
#205	SMAD1	15	21	36	1217.25
#206	MAF	15	21	36	1307.161
#207	WNT5A	15	28	43	1869.914
#208	TSC22D1	15	19	34	1431.531
#209	LASS6	15	24	39	1842.073
#210	ZEB2	15	17	32	1108.573
#211	PITX1	15	17	32	881.948
#212	PTTG1	15	14	29	1172.055
#213	STAT1	15	9	24	349.246
#214	SOX5	15	17	32	972.488
#215	HNF1B	15	14	29	404.457
#216	NPAS1	15	24	39	896.295
#217	MSL3	15	18	33	852.075
#218	RXRA	15	25	40	1406.008
#219	ATF7	15	16	31	461.539
#220	POU6F2	15	21	36	1284.949
#221	E2F3	15	16	31	1059.015
#222	XBP1	15	14	29	1518.247
#223	SREBF2	15	16	31	524.051
#224	VTN	14	18	32	1197.814
#225	ZNF202	14	16	30	1163.561
#226	ELF4	14	20	34	1587.518
#227	FOS	14	11	25	201.878
#228	ATF5	14	19	33	1223.022
#229	EVX1	14	20	34	2515.946
#230	E2F4	14	17	31	755.965
#231	CBL	14	7	21	389.16
#232	FOXO3	14	13	27	729.965
#233	HOXD1	14	16	30	880.929
#234	NFE2L1	14	12	26	388.873
#235	IRF9	14	15	29	665.323
#236	HNF1A	14	16	30	742.916
#237	RCOR1	14	19	33	896.376
#238	TGIF1	14	22	36	1108.613
#239	TFEB	14	24	38	657.492
#240	POU2F3	14	18	32	1436.006
#241	ZNF37A	14	15	29	573.771
#242	TCF3	14	26	40	1760.923
#243	TCFL5	14	21	35	1151.875
#244	FOXF2	13	17	30	1433.197
#245	TAL1	13	17	30	957.741
#246	FOXJ1	13	15	28	849.144
#247	KLF7	13	15	28	658.419
#248	ETV3	13	15	28	1044.861
#249	BATF	13	18	31	953.595
#250	NFATC4	13	12	25	1010.277
#251	HHEX	13	21	34	1264.964
#252	ZNF192	13	17	30	1633.381
#253	ST18	13	22	35	945.028
#254	ETV5	13	17	30	1438.089
#255	SOX12	13	13	26	1236.226
#256	NKX3-2	13	20	33	661.591
#257	ZIC2	13	16	29	995.725
#258	NR1H3	13	21	34	1370.223
#259	HOXD9	13	19	32	853.09
#260	EGR1	13	20	33	841.927
#261	HOXA9	13	17	30	2683.546
#262	NKX2-1	13	19	32	1679.792
#263	HOXA5	13	14	27	514.903
#264	MEIS2	13	21	34	1374.031
#265	YY1	13	18	31	1384.041
#266	AR	13	18	31	765.681
#267	TBX6	12	20	32	902.425
#268	KLF1	12	14	26	809.177
#269	E2F1	12	15	27	1376.335
#270	PBX2	12	10	22	578.021
#271	IRX5	12	22	34	1171.645
#272	UBN1	12	11	23	270.39
#273	TFAP2B	12	17	29	1134.109
#274	IRX3	12	16	28	437.998
#275	E2F5	12	13	25	427.493
#276	ZIC1	12	19	31	1753.411
#277	JUND	12	13	25	766.21
#278	EMX1	12	18	30	1037.429
#279	E2F2	12	14	26	535.921
#280	KLF4	12	17	29	977.858
#281	KDM5A	12	11	23	513.707
#282	JUNB	12	19	31	767.771
#283	SMAD9	12	11	23	389.694
#284	LHX1	12	16	28	954.147
#285	TFAP2C	12	12	24	998.688
#286	SPI1	11	22	33	967.658
#287	ZNF140	11	17	28	885.128
#288	RORC	11	18	29	684.134
#289	LMX1B	11	22	33	1110.279
#290	TEAD1	11	11	22	587.315
#291	HOXB1	11	12	23	428.326
#292	HOXB3	11	14	25	1601.044
#293	RORB	11	21	32	849.484
#294	GLI3	11	22	33	1189.491
#295	TCF21	11	21	32	1593.506
#296	PAX3	11	14	25	807.69
#297	ZNF41	11	15	26	957.219
#298	PRDM1	11	20	31	849.912
#299	ZNF132	11	16	27	692.109
#300	MYT1	11	18	29	995.979
#301	PAX8	11	21	32	1169.201
#302	HMX1	11	20	31	1071.677
#303	MEIS1	11	15	26	635.617
#304	ESRRB	11	15	26	629.715
#305	SCAND2	11	21	32	2538.594
#306	PRDM2	11	23	34	858.278
#307	FOXN2	11	19	30	690.37
#308	NFE2L3	11	14	25	612.502
#309	BNC1	11	17	28	1063.326
#310	PLAG1	11	25	36	1321.082
#311	ZNF85	11	17	28	764.819
#312	NFIB	11	22	33	1018.116
#313	HOXB2	11	22	33	1082.443
#314	SATB1	11	16	27	639.425
#315	PITX3	11	18	29	1140.571
#316	WT1	11	14	25	483.152
#317	NR6A1	11	23	34	850.001
#318	SRY	11	12	23	1019.985
#319	DLX2	11	18	29	1024.067
#320	ZKSCAN5	11	19	30	891.743
#321	ETV4	11	21	32	1194.443
#322	TBX10	10	15	25	430.348
#323	DRAP1	10	11	21	326.886
#324	NR3C2	10	21	31	607.845
#325	ARNTL	10	15	25	945.943
#326	MNX1	10	19	29	1132.181
#327	GATA3	10	11	21	816.236
#328	ZNF167	10	15	25	373.648
#329	ONECUT2	10	19	29	496.648
#330	SIM2	10	23	33	1445.265
#331	TRIM25	10	17	27	663.311
#332	TCF7L2	10	18	28	1053.902
#333	HNF4A	10	15	25	590.818
#334	ZNF268	10	20	30	1337.669
#335	MYCN	10	12	22	800.701
#336	ZFP37	10	27	37	1852.1
#337	PCGF2	10	21	31	1097.442
#338	CREM	10	21	31	587.647
#339	STAT4	10	18	28	632.653
#340	NR2F2	10	15	25	1021.792
#341	LHX2	10	24	34	2185.856
#342	HOXA2	10	22	32	779.461
#343	TCF7	10	21	31	1184.125
#344	FOXA1	10	12	22	263.409
#345	ZNF169	9	19	28	1059.952
#346	TBX5	9	21	30	803.325
#347	KLF9	9	20	29	647.685
#348	BCL6	9	24	33	612.79
#349	GBX2	9	16	25	825.096
#350	TRIM22	9	16	25	335.276
#351	GAS7	9	20	29	1498.338
#352	ALX1	9	17	26	780.082
#353	NKX2-8	9	21	30	1165.444
#354	NR1H4	9	13	22	896.499
#355	SCML2	9	20	29	485.714
#356	MLLT10	9	16	25	595.537
#357	KLF5	9	23	32	996.02
#358	EN2	9	19	28	715.323
#359	STAT5B	9	19	28	598.814
#360	PPBPL2	9	18	27	375.877
#361	RUNX2	9	12	21	611.735
#362	ASCL2	9	16	25	440.231
#363	SOX4	9	24	33	1112.401
#364	RUNX1T1	9	19	28	491.138
#365	ZFHX3	9	27	36	732.689
#366	HOXB5	9	19	28	764.072
#367	SMAD6	9	19	28	1732.818
#368	EGR4	9	19	28	969.864
#369	EGR2	9	20	29	999.044
#370	CLOCK	9	12	21	235.581
#371	TADA2A	9	14	23	267.497
#372	SIM1	9	20	29	574.938
#373	NFIA	9	21	30	967.559
#374	ZNF174	9	21	30	765.065
#375	NR2F6	9	19	28	465.623
#376	SIX1	9	16	25	678.45
#377	NR2C2	9	23	32	816.459
#378	THRB	9	20	29	468.758
#379	AEBP1	9	19	28	971.408
#380	NR5A1	8	18	26	907.57
#381	ETS2	8	19	27	885.27
#382	ZNF92	8	19	27	398.653
#383	NR4A2	8	22	30	522.025
#384	PKNOX1	8	18	26	525.594
#385	CTBP1	8	20	28	862.161
#386	POU3F4	8	20	28	1248.902
#387	RFX3	8	14	22	244.939
#388	NR4A1	8	12	20	214.164
#389	PEG3	8	25	33	1122.45
#390	MSX1	8	22	30	1109.509
#391	POU3F1	8	18	26	447.947
#392	NR1I2	8	22	30	572.553
#393	ZBTB25	8	18	26	975.23
#394	MYOD1	8	13	21	434.402
#395	HOXA4	8	16	24	949.18
#396	TBX1	8	19	27	1125.818
#397	ELK4	8	24	32	493.524
#398	ALX3	8	22	30	1123.785
#399	CUX2	8	20	28	1362.528
#400	NFIX	8	14	22	516.077
#401	PITX2	7	18	25	444.823
#402	NKX2-5	7	25	32	788.368
#403	ETV6	7	19	26	898.14
#404	MYCL1	7	26	33	642.163
#405	ZNF500	7	20	27	613.143
#406	TFDP2	7	22	29	831.472
#407	NFAT5	7	21	28	647.521
#408	CREB5	7	24	31	784.155
#409	GATA2	7	20	27	497.632
#410	HESX1	7	25	32	940.455
#411	SOX1	7	15	22	427.755
#412	ZNF135	7	14	21	493.254
#413	FOXF1	7	21	28	1026.043
#414	KLF12	7	25	32	779.529
#415	RUNX1	7	23	30	622.038
#416	TAF1B	7	18	25	631.154
#417	EGR3	7	22	29	946.94
#418	NKX3-1	7	19	26	490.418
#419	ETS1	7	24	31	490.201
#420	PROX1	7	11	18	1066.656
#421	RARG	7	15	22	607.364
#422	RORA	6	18	24	742.397
#423	RFXAP	6	13	19	215.155
#424	STAT5A	6	20	26	537.109
#425	ZNF81	6	19	25	360.458
#426	POU1F1	6	19	25	979.147
#427	NR2F1	6	21	27	866.663
#428	TEAD4	6	18	24	389.53
#429	POU4F2	6	22	28	373.889
#430	MSX2	6	18	24	460.495
#431	PPARG	6	21	27	773.063
#432	NR2E1	6	17	23	484.182
#433	C11orf9	6	25	31	463.416
#434	ZNF643	6	18	24	910.491
#435	PDX1	6	18	24	614.139
#436	SHOX	6	18	24	318.701
#437	POU4F1	6	25	31	942.003
#438	HOXA1	6	19	25	552.516
#439	TCF20	6	21	27	537.525
#440	ESR1	6	14	20	445.598
#441	PTH	6	17	23	439.484
#442	MYT1L	6	18	24	707.825
#443	NR2E3	6	18	24	464.697
#444	NR0B1	6	21	27	938.579
#445	NR5A2	6	20	26	692.92
#446	TBR1	5	22	27	617.976
#447	FOXA2	5	20	25	257.484
#448	TAF13	5	22	27	1235.623
#449	SNAI2	5	27	32	552.345
#450	SOX21	5	22	27	462.327
#451	ATF6B	5	13	18	240.381
#452	NR1I3	5	24	29	1191.249
#453	HOPX	5	22	27	321.563
#454	REL	5	20	25	442.688
#455	MAFK	5	23	28	1255.209
#456	EPAS1	5	20	25	1054.865
#457	SOX11	5	22	27	585.379
#458	KLF11	5	23	28	638.224
#459	SOX30	5	29	34	1116.02
#460	GLI2	5	16	21	785.916
#461	NRL	5	22	27	641.986
#462	HOXD10	5	20	25	362.83
#463	HES1	5	19	24	401.557
#464	ZIC3	5	24	29	732.031
#465	SALL1	4	22	26	643.517
#466	NR4A3	4	20	24	342.35
#467	FOXC1	4	24	28	616.319
#468	MYF6	4	19	23	456.007
#469	HOXD4	4	16	20	487.335
#470	FOXE1	4	22	26	940.832
#471	ZNF197	4	21	25	338.075
#472	FOXG1	4	26	30	974.054
#473	GATA6	4	17	21	421.402
#474	ZKSCAN1	4	22	26	425.707
#475	ARID4A	4	22	26	564.805
#476	ETV1	4	26	30	301.562
#477	ERG	4	27	31	451.216
#478	MEOX2	4	16	20	858.528
#479	NEUROD1	4	21	25	306.572
#480	ONECUT1	4	20	24	508.909
#481	MECOM	4	22	26	605.891
#482	ZSCAN12	3	20	23	318.106
#483	MYF5	3	19	22	103.782
#484	RARA	3	25	28	170.732
#485	ZNF154	3	27	30	261.396
#486	OLIG2	3	23	26	661.373
#487	TFEC	3	20	23	314.726
#488	GTF2H2	3	24	27	338.436
#489	SP4	3	25	28	308.758
#490	HNF4G	3	23	26	304.907
#491	HMGA2	3	20	23	438.886
#492	MEOX1	3	21	24	367.652
#493	PGR	3	19	22	366.663
#494	AFF1	2	19	21	283.111
#495	HOXD3	2	16	18	79.496
#496	PURA	2	19	21	104.298
#497	SLC26A3	2	19	21	942.042
#498	HLF	2	27	29	273.49
#499	PAX4	1	20	21	151.617
#500	NPAS2	1	14	15	32.366