Hub Rank	Node	Children	Parents	Degree	Betweenness
#1	KLF5	52	2	54	87.363
#2	BCL11B	49	3	52	1072.023
#3	FOXN3	42	6	48	1844.812
#4	IRF8	41	2	43	374.519
#5	HCLS1	40	0	40	0
#6	IRF6	38	3	41	1748.88
#7	MEF2A	36	6	42	750.179
#8	SOX10	35	7	42	2629.067
#9	KLF2	35	6	41	1712.375
#10	TRIM29	35	1	36	17.502
#11	HMGB2	34	5	39	592.005
#12	TP63	33	3	36	543.417
#13	ETV1	33	5	38	383.247
#14	KLF4	32	7	39	3028.633
#15	TFAP2A	32	5	37	543.501
#16	GATAD1	31	2	33	395.08
#17	TCF7L2	30	9	39	864.898
#18	RUNX3	30	9	39	1917.799
#19	TRIM22	30	4	34	2381.158
#20	POU3F1	29	5	34	156.809
#21	CEBPA	29	10	39	367.918
#22	CEBPD	29	10	39	1848.815
#23	TFAM	28	10	38	4134.908
#24	CBFB	28	12	40	2089.498
#25	HOPX	28	3	31	677.543
#26	RBPJL	28	11	39	2480.167
#27	SOX15	27	6	33	124.997
#28	NR3C1	26	6	32	944.17
#29	ZHX2	25	13	38	967.335
#30	MITF	25	10	35	1517.657
#31	PLSCR1	25	10	35	822.465
#32	NFYA	25	14	39	1590.295
#33	ATF1	24	7	31	1658.548
#34	ZGPAT	24	8	32	640.155
#35	ADNP2	24	7	31	793.031
#36	TFAP2B	24	15	39	710.092
#37	RORA	24	6	30	90.432
#38	AHR	24	9	33	1057.05
#39	GRHL2	23	6	29	1651.165
#40	CREB1	23	8	31	1387.521
#41	ZNF91	23	10	33	1415.752
#42	ELF1	23	11	34	827.807
#43	BATF	23	8	31	636.2
#44	POU2F3	23	6	29	124.592
#45	CREB5	22	9	31	1937.737
#46	THRB	22	6	28	856.287
#47	E2F6	22	7	29	1922.44
#48	MEF2C	22	14	36	1843.828
#49	TAF5	22	12	34	1571.947
#50	PBX1	22	14	36	1288.69
#51	HEY1	22	11	33	1986.138
#52	IRX5	22	13	35	1279.504
#53	ZEB2	21	16	37	2011.468
#54	VDR	21	18	39	1337.758
#55	IKZF1	21	4	25	58.978
#56	ZKSCAN1	21	8	29	502.735
#57	EHF	21	8	29	640.894
#58	BTG2	21	8	29	744.08
#59	TEAD4	21	8	29	1295.34
#60	HHEX	21	10	31	408.95
#61	POU4F2	21	5	26	541.669
#62	BCL3	21	12	33	914.058
#63	SATB1	21	15	36	2250.699
#64	ETS2	21	13	34	2362.97
#65	TFCP2	21	13	34	3202.754
#66	ZSCAN18	21	13	34	2023.778
#67	ZNF140	21	8	29	698.754
#68	KLF9	20	10	30	1846.526
#69	SOX9	20	16	36	1476.277
#70	RXRG	20	12	32	1645.985
#71	SPIB	20	5	25	352.985
#72	SOX4	20	14	34	1941.901
#73	FUBP1	20	9	29	900.404
#74	PRRX2	20	8	28	597.25
#75	ZNF217	20	10	30	1193.876
#76	AR	20	14	34	1141.238
#77	TEAD1	20	8	28	341.59
#78	HOXB9	19	6	25	815.107
#79	MECOM	19	13	32	2303.146
#80	OLIG2	19	10	29	771.4
#81	PRDM1	19	14	33	562.278
#82	SIM2	19	14	33	2379.018
#83	XBP1	19	7	26	495.099
#84	GAS7	19	12	31	1938.508
#85	FOSL1	19	9	28	1030.582
#86	SP140	19	8	27	496.079
#87	CBFA2T3	19	9	28	2132.925
#88	TCF12	18	11	29	2767.313
#89	PITX1	18	8	26	4807.99
#90	FOS	18	10	28	1709.268
#91	HR	18	9	27	356.277
#92	SNAI2	18	10	28	1004.178
#93	EMX1	18	10	28	677.909
#94	EGR1	18	13	31	752.188
#95	CITED1	18	15	33	812.152
#96	TFEB	18	13	31	2209.169
#97	CBL	18	12	30	814.85
#98	HOXD4	18	14	32	1927.284
#99	TCF4	18	13	31	1805.131
#100	BHLHE41	18	15	33	1076.634
#101	BACH1	18	8	26	1546.184
#102	ELF4	18	12	30	549.345
#103	GATA3	18	11	29	217.027
#104	ETV5	18	9	27	273.393
#105	TFEC	18	18	36	2947.902
#106	JUND	17	11	28	814.098
#107	NANOG	17	10	27	1652.786
#108	GATA2	17	12	29	1665.682
#109	CDKN2A	17	13	30	1671.56
#110	JUN	17	14	31	2656.102
#111	FLI1	17	10	27	755.259
#112	HLF	17	8	25	180.211
#113	HMBOX1	17	12	29	1481.557
#114	TWIST1	17	14	31	1347.594
#115	EN1	17	12	29	639.259
#116	ARNT2	17	7	24	927.893
#117	E2F5	17	10	27	2479.786
#118	ZNF117	17	8	25	514.215
#119	ZFPM2	17	11	28	2015.678
#120	MEOX1	17	12	29	595.498
#121	SRF	17	8	25	930.915
#122	NR2C2	17	9	26	1553.302
#123	NFYB	16	8	24	1073.545
#124	NR2E3	16	14	30	1334.58
#125	MZF1	16	12	28	1348.885
#126	IRF7	16	6	22	128.182
#127	YEATS4	16	14	30	874.008
#128	ZFP36L2	16	13	29	1508.294
#129	HNF1A	16	14	30	1351.421
#130	BHLHE40	16	9	25	476.338
#131	PPARA	16	13	29	2494.09
#132	TBX2	15	13	28	667.049
#133	CEBPE	15	14	29	1872.574
#134	FOXF2	15	7	22	640.424
#135	MMP14	15	12	27	1072.462
#136	MGA	15	10	25	1700.687
#137	ETV4	15	18	33	1380.158
#138	MAFF	15	14	29	988.37
#139	HOXA5	15	15	30	2400.919
#140	GABPA	15	14	29	2364.183
#141	NPAS1	15	8	23	1080.648
#142	FOSL2	15	16	31	2122.102
#143	ZNF167	15	12	27	1305.434
#144	FOXG1	15	14	29	1601.517
#145	ETV2	15	9	24	1456.992
#146	MYT1	14	9	23	458.848
#147	NKX2-8	14	13	27	1360.905
#148	ALX4	14	11	25	1743.039
#149	ARNTL2	14	16	30	3827.015
#150	FOXI1	14	6	20	681.393
#151	HOXC10	14	15	29	1320.82
#152	TBX3	14	16	30	2189.814
#153	ELK4	14	12	26	2303.237
#154	HOXA4	14	10	24	777.584
#155	CITED2	14	15	29	1809.943
#156	AEBP1	14	15	29	427.652
#157	SMAD5	14	11	25	1145.449
#158	STRN3	14	11	25	1532.787
#159	PHTF1	14	17	31	2908.176
#160	ZSCAN2	14	15	29	1925.123
#161	POU6F1	14	14	28	2259.851
#162	HOXB7	13	13	26	761.777
#163	HOXB2	13	11	24	832.072
#164	THRA	13	13	26	1885.211
#165	CREB3	13	14	27	819.579
#166	MYC	13	10	23	765.276
#167	MLXIPL	13	14	27	447.258
#168	EN2	13	13	26	756.072
#169	BACH2	13	7	20	1519.565
#170	ONECUT2	13	14	27	1562.625
#171	HMGA1	13	12	25	1127.002
#172	FOSB	13	9	22	694.87
#173	IRX4	13	8	21	593.956
#174	ECSIT	13	13	26	1442.926
#175	ZNF24	13	10	23	684.559
#176	NR4A1	13	12	25	610.804
#177	MTF1	13	14	27	1301.648
#178	NFE2	13	11	24	3435.934
#179	TEAD3	13	12	25	539.652
#180	TRPS1	13	11	24	904.873
#181	VAX2	13	10	23	665.085
#182	GATA4	13	16	29	1153.052
#183	ZSCAN12	13	15	28	1979.502
#184	NKX3-2	13	10	23	946.334
#185	RORC	12	16	28	1615.84
#186	DLX2	12	19	31	1932.369
#187	VENTX	12	12	24	1087.828
#188	ESRRA	12	19	31	2091.83
#189	ELK3	12	16	28	3407.858
#190	ZBTB48	12	12	24	2357.665
#191	PITX2	12	17	29	2354.477
#192	SOX5	12	9	21	258.356
#193	TBX10	12	13	25	1616.292
#194	TRIM25	12	11	23	877.672
#195	ZNF643	12	13	25	1123.548
#196	MSC	12	12	24	1603.612
#197	NFIX	12	10	22	459.733
#198	NPAS2	12	14	26	888.702
#199	LHX6	12	15	27	1103.575
#200	POU2F2	12	10	22	711.505
#201	NR2E1	12	14	26	543.578
#202	NR2F2	12	13	25	796.185
#203	MYT1L	12	14	26	1193.914
#204	STAT1	12	12	24	948.814
#205	HINFP	12	16	28	1574.517
#206	HOXA3	12	15	27	2390.401
#207	TAL1	12	14	26	1318.865
#208	E2F8	12	14	26	966.863
#209	FOXA2	12	10	22	1136.065
#210	KLF6	12	15	27	977.397
#211	HEY2	12	11	23	1705.527
#212	DMRT1	12	18	30	2625.091
#213	ELF3	12	11	23	1572.321
#214	TBR1	12	11	23	1354.979
#215	NR2F1	12	16	28	1698.684
#216	ZNF268	11	14	25	1086.451
#217	ZNF446	11	16	27	1021.367
#218	ZXDC	11	14	25	1691.025
#219	ESRRB	11	11	22	729.894
#220	NR6A1	11	12	23	1141.764
#221	TCF7	11	8	19	539.507
#222	SPI1	11	11	22	642.928
#223	SOX21	11	16	27	921.254
#224	MSRB2	11	17	28	1379.683
#225	MEF2D	11	13	24	1523.352
#226	CREB3L1	11	11	22	601.219
#227	TCF15	11	13	24	2124.134
#228	HMGA2	11	12	23	781.384
#229	ISL1	11	10	21	1226.185
#230	TAF12	11	15	26	1228.755
#231	NFATC3	11	13	24	1397.729
#232	RFXAP	11	14	25	934.138
#233	REL	11	10	21	943.328
#234	ELF5	11	13	24	691.796
#235	ZFHX4	11	10	21	1551.574
#236	ALS2CR8	11	13	24	1386.055
#237	IRF5	11	8	19	720.512
#238	GLI2	11	13	24	1049.697
#239	SMAD9	11	9	20	1058.635
#240	ALX1	11	14	25	831.403
#241	MYF6	11	12	23	801.144
#242	ZNF323	11	14	25	1107.29
#243	FOXO4	11	11	22	531.3
#244	FOXD2	11	11	22	1334.806
#245	FOXA1	11	13	24	1234.526
#246	FOXL2	11	10	21	3111.298
#247	ARNTL	11	14	25	872.157
#248	HOXC8	11	20	31	2316.508
#249	CBFA2T2	11	13	24	1639.882
#250	ZNF75D	11	12	23	1696.988
#251	E2F2	11	11	22	1780.538
#252	MEOX2	11	11	22	675.246
#253	HNF4A	10	10	20	577.017
#254	SOX2	10	14	24	1905.144
#255	ZNF81	10	4	14	373.543
#256	ZNF287	10	11	21	680.437
#257	NFAT5	10	20	30	1364.729
#258	ESR2	10	17	27	1352.571
#259	HOXA9	10	8	18	338.485
#260	HOXA2	10	14	24	2131.373
#261	ESRRG	10	13	23	1329.711
#262	TFDP2	10	12	22	1023.991
#263	HOXD11	10	14	24	1722.457
#264	RARB	10	19	29	1114.033
#265	TSHZ2	10	15	25	2109.604
#266	MAFB	10	5	15	175.339
#267	HOXB1	10	13	23	416.645
#268	OVOL1	10	11	21	331.031
#269	RUNX2	10	9	19	718.247
#270	ARID3A	10	8	18	1049.11
#271	BATF3	10	16	26	921.808
#272	STAT2	10	13	23	726.381
#273	RFX3	10	10	20	759.349
#274	GATA1	10	16	26	1457.054
#275	NRL	10	10	20	1090.489
#276	ZEB1	10	15	25	1263.806
#277	MAX	10	10	20	1395.047
#278	ATF6B	10	12	22	956.177
#279	EVX1	10	12	22	728.362
#280	FOXO3	10	11	21	1285.87
#281	MXD1	10	14	24	792.147
#282	TBX4	10	12	22	1415.864
#283	PLAG1	10	18	28	1568.196
#284	NR0B1	10	21	31	1870.687
#285	LHX2	10	18	28	1310.813
#286	FOXC1	10	14	24	1108.848
#287	ZIC1	10	14	24	775.81
#288	C11orf9	9	15	24	1369.602
#289	GABPB1	9	18	27	906.455
#290	PAX3	9	11	20	410.065
#291	NR5A1	9	13	22	944.423
#292	CREBBP	9	14	23	1045.438
#293	PAX7	9	12	21	629.005
#294	SIX1	9	10	19	698.343
#295	NR4A3	9	16	25	1298.681
#296	FOXD1	9	23	32	2721.416
#297	E2F1	9	10	19	342.213
#298	HOXD1	9	12	21	1471.931
#299	SLC26A3	9	12	21	1818.948
#300	PAX6	9	11	20	613.212
#301	MAFK	9	17	26	1067.386
#302	SOX13	9	10	19	571.273
#303	ATF5	9	13	22	943.856
#304	ZNF93	9	13	22	557.855
#305	NR1I2	9	16	25	1259.607
#306	PKNOX2	9	18	27	598.348
#307	HIF3A	9	12	21	925.956
#308	IRF4	9	15	24	1480.838
#309	DBP	9	16	25	1463.909
#310	FOXP3	9	9	18	348.409
#311	NKX2-1	9	10	19	927.667
#312	RCAN1	9	12	21	1935.339
#313	RXRB	9	17	26	921.324
#314	HOXD13	9	13	22	1195.513
#315	TAF13	9	10	19	1658.91
#316	PDX1	9	10	19	451.655
#317	ZNF154	9	14	23	1187.791
#318	SMAD6	9	10	19	776.467
#319	GBX2	9	13	22	957.181
#320	KLF15	9	14	23	970.255
#321	TSC22D2	9	15	24	1074.02
#322	ZNF444	9	15	24	684.809
#323	NFIB	8	15	23	1024.106
#324	TAF1B	8	13	21	517.752
#325	MLLT10	8	18	26	1305.369
#326	MLL	8	15	23	878.772
#327	BNC1	8	9	17	202.854
#328	GATA6	8	17	25	1597.957
#329	POU3F4	8	11	19	732.763
#330	POU1F1	8	16	24	1401.235
#331	MYCL1	8	10	18	1375.492
#332	TCF21	8	15	23	916.056
#333	POU4F1	8	12	20	452.949
#334	PAX4	8	12	20	588.545
#335	ZFP37	8	16	24	1195.435
#336	FOXM1	8	15	23	1236.069
#337	TBX5	8	17	25	996.344
#338	RERE	8	18	26	1123.368
#339	POU3F2	8	16	24	1347.158
#340	ZNF175	8	12	20	868.281
#341	FOXC2	8	12	20	906.492
#342	SCML1	8	12	20	738.742
#343	NR1H4	8	11	19	732.246
#344	BLZF1	8	21	29	1075.053
#345	ZNF434	8	7	15	425.595
#346	NFATC4	8	11	19	701.49
#347	HNF1B	8	14	22	663.7
#348	EGR2	8	15	23	867.538
#349	CSDA	8	14	22	943.305
#350	ZSCAN16	8	12	20	1090.241
#351	HOXC13	8	8	16	463.104
#352	SCAND2	8	9	17	652.568
#353	RORB	8	11	19	1139.273
#354	MAF	8	12	20	445.805
#355	WNT5A	8	17	25	1028.088
#356	NEUROD1	8	12	20	726.543
#357	ZNF236	8	15	23	1485.159
#358	LEF1	8	15	23	1027.279
#359	ATF6	8	15	23	930.135
#360	NEUROG1	8	17	25	1193.592
#361	HIC1	7	11	18	667.063
#362	POU6F2	7	9	16	691.36
#363	TCF3	7	17	24	1888.2
#364	ZNF3	7	15	22	827
#365	ELK1	7	13	20	715.19
#366	NPAT	7	15	22	1411.549
#367	HESX1	7	13	20	728.446
#368	YY1	7	12	19	803.347
#369	HOXD3	7	21	28	1445.989
#370	NFATC1	7	16	23	1144.496
#371	CREM	7	16	23	584.092
#372	SOX11	7	15	22	1719.383
#373	T	7	14	21	855.031
#374	ZNF174	7	17	24	1281.451
#375	RARA	7	16	23	1340.452
#376	MYF5	7	17	24	681.962
#377	MYCN	7	17	24	595.251
#378	ZFHX3	7	12	19	1740.835
#379	NFKB2	7	17	24	672.042
#380	RARG	7	15	22	961.834
#381	CNOT8	7	12	19	923.491
#382	TBX6	7	13	20	631.839
#383	ZBTB25	7	15	22	916.466
#384	PHOX2B	7	17	24	1327.635
#385	NR4A2	7	18	25	863.146
#386	ELF2	7	10	17	417.779
#387	PAX5	7	15	22	838.592
#388	PPARG	7	17	24	754.295
#389	NR3C2	7	16	23	1116.778
#390	PHF1	7	12	19	519.523
#391	TP53	7	16	23	1281.419
#392	PKNOX1	7	12	19	499.942
#393	LZTS1	7	15	22	515.338
#394	MYBL2	7	14	21	844.341
#395	REST	7	15	22	742.982
#396	SPDEF	7	9	16	403.117
#397	IKZF3	6	15	21	602.406
#398	TBX19	6	11	17	277.281
#399	KDM5B	6	14	20	617.59
#400	HOXA6	6	16	22	815.378
#401	PRDM2	6	13	19	554.596
#402	POU4F3	6	14	20	1074.162
#403	ARNT	6	10	16	1075.504
#404	HMX1	6	8	14	301.428
#405	SMAD3	6	15	21	780.756
#406	HOXC5	6	12	18	613.679
#407	TP73	6	13	19	1015.718
#408	TEF	6	13	19	444.428
#409	SMAD1	6	15	21	880.259
#410	ZHX3	6	11	17	412.329
#411	HOXB6	6	16	22	699.034
#412	WT1	6	12	18	626.584
#413	ZNF134	6	14	20	813.256
#414	SIM1	6	14	20	753.067
#415	SALL1	6	18	24	817.702
#416	ZNF135	6	12	18	518.991
#417	PAX8	6	16	22	1687.025
#418	SP4	6	8	14	240.314
#419	ERG	6	6	12	224.241
#420	POU3F3	6	10	16	227.152
#421	MNX1	6	14	20	384.662
#422	RB1	6	14	20	922.928
#423	PHOX2A	6	15	21	828.014
#424	MYOD1	6	11	17	389.024
#425	BARX1	6	15	21	869.221
#426	TFAP2C	6	14	20	420.879
#427	ZNF45	6	12	18	648.014
#428	ZNF41	6	14	20	1281.69
#429	ASCL1	6	13	19	820.618
#430	TFDP3	6	13	19	450.905
#431	VSX1	5	14	19	842.022
#432	C2orf3	5	14	19	456.371
#433	SATB2	5	10	15	768.296
#434	PPARD	5	14	19	547.843
#435	LHX1	5	13	18	924.655
#436	ZNF83	5	17	22	678.149
#437	ZNF155	5	16	21	1064.814
#438	PPBPL2	5	14	19	763.47
#439	CUX2	5	15	20	835.182
#440	ALX3	5	17	22	410.33
#441	NKX2-5	5	18	23	958.309
#442	HOXA10	5	18	23	400.913
#443	BRD8	5	15	20	699.187
#444	ZNF157	5	14	19	891.368
#445	HOXA1	5	13	18	785.764
#446	HOXA7	5	11	16	822.561
#447	CTBP1	5	14	19	421.133
#448	FOXH1	5	16	21	697.544
#449	PGR	5	14	19	368.038
#450	ONECUT1	5	17	22	953.434
#451	NR2C1	5	10	15	422.984
#452	NFX1	5	19	24	1046.412
#453	FOXB1	5	10	15	489.439
#454	TBX1	5	12	17	494.841
#455	SP1	5	12	17	454.395
#456	SNAPC5	5	14	19	1093.273
#457	FOXD3	5	9	14	301.486
#458	HOXD9	5	11	16	310.696
#459	PROX1	5	18	23	1076.66
#460	SIX3	5	11	16	603.196
#461	KLF12	5	10	15	439.299
#462	NR2F6	5	12	17	577.213
#463	ZNF277	5	8	13	387.627
#464	ZNF500	5	12	17	1246.156
#465	TSC22D3	4	16	20	731.13
#466	HOXA11	4	15	19	318.145
#467	CSRNP3	4	11	15	249.893
#468	TLX3	4	14	18	618.297
#469	MSX2	4	16	20	399.08
#470	ZNF238	4	13	17	742.15
#471	ST18	4	12	16	821.977
#472	RUNX1	4	16	20	750.387
#473	HNF4G	4	9	13	416.957
#474	VTN	4	13	17	302.481
#475	MBD1	4	14	18	459.063
#476	ATOH1	3	15	18	466.545
#477	SRY	3	17	20	301.625
#478	ZIC3	3	13	16	181.389
#479	FOXE1	3	15	18	392.885
#480	RUNX1T1	3	14	17	149.055
#481	PTH	3	16	19	424.374
#482	SOX30	3	11	14	223.377
#483	HOXB8	3	16	19	1006.707
#484	CREBZF	3	17	20	887.615
#485	TADA2A	3	14	17	348.099
#486	HOXB3	3	15	18	681.7
#487	ZFP36L1	3	11	14	252.041
#488	GSC2	3	16	19	363.565
#489	ESR1	2	13	15	332.439
#490	HMG20B	2	14	16	558.004
#491	HES1	2	15	17	268.69
#492	GCM1	2	13	15	221.215
#493	SCRT1	2	21	23	180.565
#494	TLX2	2	17	19	404.747
#495	ZNF639	2	16	18	256.401
#496	EGR4	2	15	17	503.403
#497	ZNF165	2	15	17	168.782
#498	ZNF80	2	14	16	335.699
#499	ZNF202	2	12	14	154.299
#500	NR5A2	1	11	12	150.689