Hub Rank	Node	Children	Parents	Degree	Betweenness
#1	HES6	53	3	56	33321.408
#2	HOXB2	46	1	47	270.495
#3	SOX2	45	8	53	801.386
#4	ONECUT2	39	5	44	1067.769
#5	MEIS1	36	10	46	2049.547
#6	ZNF446	33	1	34	268.23
#7	PAX8	31	3	34	1767.985
#8	HOXB6	30	2	32	144.223
#9	HOXC10	28	7	35	1349.364
#10	AHR	28	5	33	1303.369
#11	PBX1	27	7	34	1209.802
#12	GLI2	27	4	31	980.322
#13	NKX3-1	27	10	37	1265.478
#14	CREB3L4	27	7	34	1626.643
#15	KLF5	27	4	31	297.7
#16	RUNX2	26	12	38	1984.435
#17	C5orf41	25	3	28	222.262
#18	ETS2	24	6	30	298.481
#19	SP1	24	7	31	21038.479
#20	CEBPB	24	11	35	3218.145
#21	SIX3	24	5	29	4292.161
#22	KLF4	23	10	33	2369.253
#23	PPARG	23	8	31	1733.075
#24	JUNB	22	5	27	316.304
#25	HOXD9	22	5	27	1325.411
#26	FOXP1	22	11	33	1266.142
#27	ZNF396	22	7	29	509.482
#28	HOXB3	22	6	28	134.651
#29	MEIS2	21	8	29	1863.671
#30	ZNF193	21	12	33	13205.336
#31	ESX1	21	6	27	306.115
#32	TBX1	20	7	27	700.781
#33	GATA3	20	6	26	305.047
#34	EHF	20	8	28	548.443
#35	IRX5	20	7	27	386.499
#36	SOX1	20	5	25	697.188
#37	SPDEF	20	7	27	483.119
#38	HOXB7	20	5	25	209.044
#39	ESR1	19	9	28	656.566
#40	TFAP2A	19	5	24	1455.955
#41	TBX3	18	3	21	277.288
#42	DMRT2	18	5	23	828.433
#43	HOXA2	18	9	27	975.191
#44	IRX3	18	9	27	582.386
#45	HOXC4	18	8	26	391.13
#46	ZSCAN2	18	6	24	2913.372
#47	HMGA2	17	12	29	2847.35
#48	ZNF207	17	5	22	1534.116
#49	ST18	17	7	24	786.526
#50	ZXDC	17	5	22	541.379
#51	TCF4	17	5	22	569.976
#52	TFAP4	17	3	20	1395.274
#53	FOXQ1	17	9	26	645.383
#54	TFCP2L1	17	7	24	519.581
#55	HOXC5	17	8	25	2020.888
#56	TWIST1	17	4	21	1357.124
#57	E2F7	17	2	19	100.754
#58	GATA6	17	7	24	286.878
#59	GTF2I	17	6	23	4392.115
#60	SREBF1	17	11	28	54946.43
#61	HOXC9	16	5	21	849.898
#62	RARG	16	9	25	6823.703
#63	ZNF83	16	7	23	40949.336
#64	DLX1	16	12	28	3329.269
#65	ATF6B	16	5	21	1130.916
#66	ZNF165	16	10	26	734.47
#67	TRPS1	16	12	28	1947.03
#68	MITF	16	11	27	2969.381
#69	ZNF277	16	8	24	18853.388
#70	E2F4	15	10	25	13002.186
#71	KLF2	15	10	25	2592.687
#72	SCRT1	15	12	27	2370.644
#73	GLI3	15	8	23	1326.439
#74	NEUROG1	15	7	22	2697.412
#75	SIX5	15	8	23	907.891
#76	FOXA1	15	6	21	921.915
#77	MLL	15	8	23	818.027
#78	BTG2	15	8	23	435.065
#79	NPAS2	15	8	23	945.351
#80	STAT1	14	10	24	1779.688
#81	ETV4	14	7	21	3636.948
#82	MLX	14	8	22	612.646
#83	PITX1	14	13	27	3420.02
#84	MYCL1	14	6	20	551.333
#85	AFF4	14	9	23	2859.796
#86	SOX21	14	11	25	3032.838
#87	NFIX	14	6	20	1252.199
#88	MEF2C	14	6	20	720.955
#89	MGA	14	8	22	1773.916
#90	HEY1	14	12	26	388.932
#91	HEY2	14	9	23	48328.22
#92	HOXA1	14	12	26	739.768
#93	FOS	14	10	24	4388.324
#94	LHX2	14	6	20	258.73
#95	USF1	13	10	23	6326.754
#96	HOXA3	13	11	24	2346.522
#97	SLC2A4RG	13	15	28	5882.476
#98	HOXB9	13	6	19	299.114
#99	CEBPA	13	8	21	562.298
#100	CTBP1	13	8	21	2559.872
#101	ZSCAN18	13	5	18	123.229
#102	BHLHE40	13	15	28	19497.92
#103	PHTF1	13	5	18	469.288
#104	NR1D2	13	5	18	2565.215
#105	HES1	13	9	22	853.707
#106	EPAS1	13	11	24	543.893
#107	SCML1	13	13	26	12243.819
#108	NR2F2	13	12	25	913.244
#109	NFE2L3	13	6	19	431.532
#110	TEF	12	11	23	520.586
#111	HOXA10	12	8	20	280.572
#112	SOX4	12	11	23	975.614
#113	MYC	12	10	22	5500.036
#114	ETS1	12	9	21	787.766
#115	BHLHE41	12	9	21	499.135
#116	IKZF4	12	6	18	328.224
#117	FOXN3	12	11	23	4429.608
#118	SMAD2	12	6	18	3268.282
#119	SMAD9	12	11	23	6180.453
#120	GATAD2B	12	11	23	5742.3
#121	SOX12	12	10	22	637.081
#122	LHX6	12	11	23	766.299
#123	NOTCH1	12	11	23	1582.44
#124	JDP2	12	6	18	1190.763
#125	CREB5	12	5	17	136.164
#126	SOX9	12	4	16	259.113
#127	NR2F6	12	10	22	1560.546
#128	ZEB2	12	6	18	449.46
#129	SIX1	12	9	21	871.313
#130	LASS6	11	9	20	1161.076
#131	FOXJ1	11	5	16	246.169
#132	TRIM22	11	9	20	731.194
#133	BCL11B	11	12	23	966.568
#134	ELF5	11	8	19	297.4
#135	IRX4	11	7	18	1543.379
#136	SIX2	11	9	20	524.688
#137	NR4A2	11	13	24	1153.045
#138	RUNX1	11	7	18	281.462
#139	ARNTL2	11	12	23	581.806
#140	ZIC2	11	10	21	21940.168
#141	SMAD3	11	10	21	1294.103
#142	ZFHX3	11	12	23	1345.44
#143	BACH2	11	14	25	3440.766
#144	MAFF	11	13	24	2632.883
#145	BARX1	11	9	20	2405.111
#146	NFIB	11	9	20	2400.126
#147	FOXC1	11	10	21	9387.342
#148	TFAP2B	11	9	20	1149.813
#149	IRF8	11	12	23	3356.158
#150	SMAD5	11	9	20	19023.512
#151	CBFA2T3	11	7	18	541.993
#152	JUND	10	7	17	2912.218
#153	FOXN4	10	5	15	140.028
#154	PRRX2	10	9	19	1335.302
#155	HOPX	10	11	21	567.057
#156	TCF25	10	10	20	1280.971
#157	NKX6-1	10	12	22	4428.65
#158	FOXL1	10	6	16	578.362
#159	ZNF287	10	7	17	1880.459
#160	MTA3	10	9	19	317.603
#161	EGR3	10	8	18	594.335
#162	VSX1	10	8	18	565.616
#163	ZNF449	10	10	20	946.658
#164	HOXA13	10	6	16	383.316
#165	EN1	10	7	17	2404.562
#166	FOXO3	10	10	20	1336.754
#167	PROX1	10	10	20	6377.212
#168	PGR	10	13	23	617.434
#169	NFYA	10	9	19	1667.453
#170	ZNF483	10	8	18	1728.958
#171	HNF4G	10	8	18	3130.206
#172	RCAN1	10	10	20	1314.869
#173	MYCN	10	7	17	2058.811
#174	PRDM1	10	8	18	2588.791
#175	CREBZF	10	8	18	2158.215
#176	ZNF81	9	10	19	2479.717
#177	TBX20	9	7	16	3649.89
#178	SCAND2	9	10	19	2593.567
#179	ZKSCAN1	9	7	16	444.062
#180	TFCP2	9	6	15	290.645
#181	TADA3	9	3	12	166.572
#182	MAF	9	10	19	3418.258
#183	TCF3	9	10	19	2693.199
#184	TCF7L2	9	8	17	4047.335
#185	HLF	9	8	17	8826.209
#186	ZNF132	9	7	16	363.92
#187	SOX17	9	5	14	813.947
#188	FOXP4	9	12	21	694.536
#189	HOXA4	9	8	17	1107.683
#190	FOSL2	9	13	22	12311.8
#191	HAND2	9	12	21	2498.464
#192	NRL	9	7	16	1079.449
#193	TULP4	9	12	21	2162.688
#194	SIM2	9	8	17	484.488
#195	BATF2	9	12	21	719.398
#196	LMX1A	9	5	14	1399.837
#197	ASCL2	9	7	16	538.132
#198	TFAP2C	9	11	20	624.347
#199	TCF7	9	9	18	767.406
#200	WNT5A	9	9	18	2652.52
#201	ZBTB38	9	7	16	792.315
#202	ASCL1	9	15	24	5362.368
#203	HOXD10	9	12	21	1302.699
#204	MXD1	9	14	23	2686.794
#205	ELF1	9	11	20	1270.367
#206	POU2F2	9	10	19	9651.116
#207	GATA4	8	14	22	2086.71
#208	VTN	8	10	18	385.351
#209	LEF1	8	12	20	1378.977
#210	ELK4	8	12	20	972.87
#211	POU3F1	8	10	18	1401.527
#212	HHEX	8	8	16	205.901
#213	PURB	8	5	13	415.65
#214	DLX2	8	10	18	234.977
#215	FOXP2	8	9	17	4079.531
#216	PAX5	8	11	19	1666.747
#217	NR4A3	8	7	15	465.782
#218	MSX2	8	8	16	1090.333
#219	EBF1	8	7	15	501.258
#220	SOX6	8	10	18	189.041
#221	NFKB2	8	17	25	3128.582
#222	MYT1L	8	8	16	2488.02
#223	KLF6	8	10	18	3342.5
#224	ZFP36L1	8	10	18	360.76
#225	TFAP2E	8	10	18	1025.905
#226	REL	8	7	15	926.161
#227	NR2F1	8	4	12	337.895
#228	NR5A2	8	11	19	2014.189
#229	TP53	8	8	16	1303.243
#230	HMX1	8	12	20	689.402
#231	NFAT5	8	9	17	1123.046
#232	TBR1	8	14	22	3945.517
#233	EGR2	8	9	17	2383.683
#234	MECOM	8	14	22	524.845
#235	OTX2	8	7	15	380.384
#236	EVX1	8	8	16	1469.199
#237	CREB3L2	8	4	12	50.299
#238	HIC1	8	13	21	2032.476
#239	ZFHX4	7	8	15	1367.596
#240	BCL3	7	12	19	38346.284
#241	LZTS1	7	8	15	352.592
#242	CREM	7	7	14	12769.671
#243	NR2E3	7	7	14	620.474
#244	TAF10	7	8	15	575.077
#245	PKNOX2	7	10	17	1104.378
#246	ZNF175	7	12	19	2522.743
#247	ZNF238	7	5	12	385.702
#248	SCAND1	7	9	16	784.987
#249	EGR1	7	13	20	482.839
#250	HMG20B	7	8	15	1173.88
#251	ZSCAN23	7	6	13	883.04
#252	GSX2	7	8	15	2580.417
#253	DMBX1	7	9	16	1680.419
#254	TBX4	7	11	18	1198.856
#255	POU6F2	7	8	15	1210.918
#256	NR2E1	7	7	14	2182.021
#257	SIN3A	7	9	16	1628.308
#258	ZNF91	7	8	15	507.194
#259	AR	7	9	16	929.787
#260	C11orf9	7	10	17	2320.59
#261	MLLT10	7	13	20	1074.406
#262	ZNF496	7	13	20	3956.514
#263	NR4A1	7	9	16	240.455
#264	NFATC3	7	10	17	1368.554
#265	TSC22D2	7	8	15	132.848
#266	SIM1	7	9	16	1047.116
#267	NANOGNB	7	9	16	1279.716
#268	SPEN	7	8	15	1012.705
#269	HOXD11	7	10	17	3492.319
#270	ALX3	7	7	14	1919.775
#271	ZSCAN4	7	8	15	1319.635
#272	SLC26A3	7	10	17	2118.985
#273	CITED2	7	13	20	23084.006
#274	ZNF135	7	8	15	874.366
#275	LHX8	7	12	19	1062.115
#276	NR0B1	7	9	16	651.005
#277	FOXJ2	7	9	16	2311.092
#278	NFATC4	7	10	17	344.058
#279	HOXA9	7	11	18	673.374
#280	SATB1	7	12	19	1034.656
#281	ZNF397	7	10	17	2094.208
#282	RXRB	7	8	15	822.411
#283	CLOCK	7	11	18	2149.663
#284	ISL2	7	6	13	1726.694
#285	PAX7	7	8	15	135.867
#286	NR2C1	6	11	17	497.834
#287	FOXP3	6	6	12	191.007
#288	ETV5	6	8	14	430.443
#289	EOMES	6	7	13	179.559
#290	MBD1	6	8	14	3781.682
#291	TP63	6	10	16	732.827
#292	ZIC3	6	7	13	1219.17
#293	LASS5	6	10	16	1665.014
#294	HCFC1	6	9	15	721.372
#295	POU1F1	6	11	17	4393.046
#296	NR3C2	6	9	15	1330.054
#297	CUX2	6	10	16	1427.738
#298	SOX5	6	10	16	1237.919
#299	DLX3	6	10	16	1472.169
#300	NR3C1	6	8	14	910.751
#301	TSC22D1	6	8	14	335.691
#302	MIXL1	6	12	18	1389.049
#303	ZFP42	6	11	17	1982.15
#304	TCF15	6	9	15	1530.54
#305	ZNF90	6	7	13	842.377
#306	KDM5A	6	9	15	2261.496
#307	LHX3	6	9	15	1063.693
#308	PAX3	6	8	14	2868.098
#309	NEUROD1	6	8	14	646.501
#310	NR6A1	6	10	16	1006.018
#311	FLI1	6	13	19	1046.466
#312	BCL6	6	9	15	571.4
#313	PLSCR1	6	13	19	530.59
#314	TLX2	6	13	19	3179.337
#315	ATF2	6	9	15	1397.396
#316	FOXG1	6	10	16	1343.897
#317	RUNX3	6	12	18	1192.725
#318	SMAD6	6	8	14	5413.549
#319	SNAI2	6	10	16	40756.844
#320	MSX1	6	11	17	1139.233
#321	ISL1	6	9	15	1418.626
#322	HOXA11	6	12	18	988.553
#323	ATOH1	6	10	16	949.209
#324	SOX10	6	10	16	2449.294
#325	FOXK2	6	14	20	1168.67
#326	MYNN	6	10	16	879.98
#327	HOXB5	6	10	16	116.344
#328	RARA	5	12	17	653.023
#329	FOXH1	5	10	15	1218.032
#330	HDX	5	11	16	556.53
#331	ESRRB	5	9	14	744.302
#332	ERG	5	10	15	712.37
#333	ZFP37	5	7	12	1149.647
#334	FOXD3	5	15	20	500.799
#335	GLIS3	5	11	16	659.25
#336	ZFP36L2	5	7	12	3746.751
#337	POU3F2	5	9	14	923.794
#338	POU2F1	5	14	19	1861.992
#339	SIX6	5	11	16	1185.707
#340	TBX5	5	10	15	872.167
#341	VENTX	5	5	10	386.865
#342	TFEC	5	10	15	888.735
#343	IRF6	5	11	16	748.342
#344	ETV6	5	14	19	674.416
#345	SOX30	5	10	15	1416.192
#346	BARHL1	5	9	14	531.477
#347	HNF4A	5	7	12	971.307
#348	FUBP1	5	9	14	1482.829
#349	HNF1B	5	8	13	164.718
#350	FOXI1	5	8	13	1048.532
#351	OLIG2	5	10	15	2702.918
#352	FOXO1	5	9	14	183.319
#353	TLX1	5	15	20	2392.016
#354	TEAD2	5	12	17	594.954
#355	ZNF71	5	13	18	2484.096
#356	KDM5B	5	10	15	3942.551
#357	RUNX1T1	5	12	17	933.579
#358	CRX	5	9	14	651.515
#359	ZNF628	5	13	18	17930.663
#360	TCF21	5	8	13	603.804
#361	ZSCAN12	5	9	14	1287.969
#362	FOXR1	5	9	14	1710.413
#363	MEOX2	5	10	15	205.104
#364	POU5F2	5	8	13	1358.782
#365	PPARA	5	10	15	846.43
#366	PRDM2	5	9	14	1118.599
#367	NR1I2	5	7	12	136.605
#368	PDX1	5	11	16	1554.622
#369	POU4F2	5	12	17	948.318
#370	TBX15	5	9	14	329.705
#371	BACH1	5	6	11	78.643
#372	FOXA3	5	8	13	902.142
#373	ZNF192	5	8	13	715.062
#374	ETV1	5	9	14	6374.673
#375	RFX1	5	12	17	4140.477
#376	HMX2	5	10	15	444.284
#377	TAF4	5	9	14	838.779
#378	MYF5	5	6	11	217.34
#379	ZNF197	5	15	20	1183.916
#380	CITED1	5	14	19	324.42
#381	HESX1	5	11	16	1316.74
#382	IKZF1	5	4	9	43.622
#383	MMP14	4	11	15	1007.882
#384	ZEB1	4	14	18	552.877
#385	RBPJL	4	6	10	877.543
#386	BNC1	4	11	15	986.277
#387	ZSCAN5A	4	7	11	483.008
#388	HOXD1	4	6	10	1031.696
#389	HOXB13	4	9	13	1398.394
#390	TLX3	4	11	15	2272.779
#391	ZNF154	4	6	10	243.013
#392	MYT1	4	13	17	1433.297
#393	GATA5	4	8	12	755.667
#394	CSDA	4	11	15	3669.811
#395	NR1I3	4	7	11	682.64
#396	THRB	4	8	12	360.275
#397	NFIA	4	11	15	253.455
#398	RORA	4	7	11	278.886
#399	PURA	4	7	11	485.857
#400	RXRG	4	13	17	1199.56
#401	MYOG	4	13	17	1676.415
#402	ARNT	4	9	13	375.465
#403	NKX2-3	4	13	17	8215.319
#404	ELF3	4	7	11	511.06
#405	ZIC5	4	12	16	498.661
#406	CBL	4	10	14	1188.596
#407	ZNF117	4	16	20	569.015
#408	ZNF438	4	9	13	280.448
#409	ZNF92	4	8	12	1704.822
#410	CDX2	4	11	15	1242.832
#411	HOXD13	4	11	15	714.307
#412	RORB	4	6	10	92.303
#413	POU6F1	4	11	15	2878.177
#414	HMGB2	4	8	12	2255.905
#415	TAL1	4	11	15	714.413
#416	SPI1	4	6	10	794.129
#417	PTH	4	7	11	753.277
#418	ZNF169	4	8	12	621.74
#419	ZNF85	4	5	9	1513.267
#420	FOXL2	4	6	10	1000.164
#421	FOXC2	4	8	12	3813.444
#422	PGBD1	4	8	12	905.954
#423	FOXD1	4	7	11	789.684
#424	GCM1	4	6	10	862.58
#425	TBX22	4	7	11	842.375
#426	ZNF215	4	6	10	194.188
#427	FOXK1	4	9	13	145.773
#428	WT1	4	16	20	2019.929
#429	FOSB	4	11	15	454.879
#430	AHCTF1	4	10	14	294.968
#431	ZNF80	4	4	8	81.587
#432	CSRNP3	4	11	15	1817.003
#433	PPARD	4	9	13	487.832
#434	ZNF3	3	13	16	689.619
#435	MKX	3	8	11	131.214
#436	IRF4	3	10	13	697.214
#437	TSHZ3	3	10	13	421.62
#438	NEUROD2	3	14	17	1064.059
#439	KLF12	3	13	16	1362.968
#440	FOXN1	3	8	11	1099.854
#441	HOXB8	3	11	14	1479.638
#442	GAS7	3	14	17	441.773
#443	CDKN2A	3	8	11	355.076
#444	FOXE3	3	13	16	685.712
#445	TSHZ2	3	9	12	294.335
#446	ALS2CR8	3	9	12	2643.898
#447	FEV	3	10	13	1482.488
#448	TEAD1	3	6	9	318.894
#449	ETV7	3	7	10	140.7
#450	HOXD3	3	11	14	1975.834
#451	RERE	3	12	15	1159.019
#452	RB1	3	14	17	407.467
#453	SOX7	3	7	10	1763.407
#454	PITX3	3	11	14	553.307
#455	LMO4	3	12	15	747.348
#456	MEOX1	3	12	15	1089.365
#457	SP4	3	9	12	579.986
#458	ZNF219	3	9	12	353.272
#459	PEG3	3	8	11	67.63
#460	HIF3A	3	12	15	586.246
#461	NPAT	3	9	12	384.361
#462	PBX3	3	10	13	410.388
#463	CREB3L1	3	11	14	599.456
#464	DMRT1	2	6	8	309.995
#465	POU3F3	2	10	12	168.105
#466	RARB	2	14	16	581.81
#467	SHOX	2	8	10	196.732
#468	ATF7	2	10	12	412.17
#469	FOXB1	2	7	9	53.348
#470	NFATC1	2	10	12	1702.933
#471	NFATC2	2	11	13	308.513
#472	ZKSCAN3	2	7	9	77.752
#473	E2F2	2	13	15	717.635
#474	NKX2-5	2	7	9	420.234
#475	GSX1	2	13	15	134.745
#476	TFAP2D	2	12	14	411.318
#477	DLX6	2	8	10	232.45
#478	ZBTB48	2	13	15	147.834
#479	HES5	2	12	14	2088.515
#480	KLF9	2	8	10	392.2
#481	ISX	2	10	12	498.071
#482	KCNH8	2	10	12	1300.316
#483	CEBPD	2	11	13	463.967
#484	ZSCAN20	2	10	12	2334.983
#485	NR1H4	2	13	15	582.422
#486	FOXE1	2	9	11	1255.605
#487	GSC	2	9	11	272.941
#488	FOXA2	1	10	11	184.87
#489	ATF5	1	11	12	596.122
#490	NKX2-1	1	9	10	231.728
#491	BUD31	1	14	15	104.737
#492	LHX9	1	14	15	384.403
#493	MYOD1	1	11	12	462.649
#494	ZNF167	1	13	14	168.604
#495	ZNF157	1	9	10	88.441
#496	SOX11	1	10	11	359.178
#497	KLF16	1	16	17	577.629
#498	LHX5	1	10	11	464.169
#499	ELK1	0	10	10	0
#500	ZFPM2	0	7	7	0