Hub Rank	Node	Children	Parents	Degree	Betweenness
#1	E2F4	74	2	76	653.294
#2	RARG	55	4	59	5370.066
#3	HSF2	47	6	53	635.267
#4	TFAP2C	46	8	54	1456.501
#5	HNF1B	44	1	45	192.797
#6	ZNF639	44	12	56	1980.294
#7	E2F7	44	6	50	1027.922
#8	PPARD	43	7	50	297.942
#9	TFAM	42	4	46	224.047
#10	MXD1	41	10	51	3915.501
#11	GRHL2	41	7	48	440.836
#12	SOX15	40	9	49	1866.5
#13	SMAD4	40	4	44	89.387
#14	SIX4	40	6	46	1262.478
#15	YEATS4	39	5	44	933.799
#16	CNOT8	38	5	43	332.271
#17	REST	37	2	39	22.649
#18	SCML1	37	5	42	2539.205
#19	ZNF238	35	8	43	3087.803
#20	POU2F1	35	14	49	1324.96
#21	HNRNPK	35	8	43	2557.497
#22	SOX4	34	16	50	2531.678
#23	ZNF33A	33	6	39	590.698
#24	PHF1	33	11	44	594.779
#25	NFYB	33	6	39	561.886
#26	MESP1	32	3	35	843.501
#27	TEAD4	32	8	40	1643.198
#28	ARID4A	32	7	39	1114.196
#29	HOPX	32	11	43	7739.477
#30	PCGF6	32	7	39	548.17
#31	E2F3	32	11	43	711.87
#32	ZNF148	32	4	36	884.422
#33	ENO1	32	2	34	75.741
#34	CREB3L1	32	6	38	1372.616
#35	ZNF45	31	4	35	1265.771
#36	E4F1	31	5	36	707.367
#37	ARNT2	31	10	41	2092.389
#38	GRHL3	31	8	39	936.233
#39	FUBP1	31	10	41	864.718
#40	ETV1	30	15	45	2499.75
#41	NOLC1	29	9	38	1219.66
#42	SIX1	29	14	43	821.474
#43	ZNF367	28	11	39	468.856
#44	C2orf3	28	10	38	1698.627
#45	MZF1	28	5	33	566.697
#46	ADNP2	27	11	38	660.838
#47	NFE2L3	27	11	38	716.363
#48	OVOL1	27	6	33	796.913
#49	UHRF1	27	10	37	375.051
#50	GTF2H4	26	8	34	530.933
#51	ATF2	26	13	39	544.808
#52	RFX5	26	8	34	1063.763
#53	HOXA3	26	16	42	2054.126
#54	SPEN	25	3	28	380.408
#55	PAX8	25	8	33	458.116
#56	HR	25	5	30	2150.842
#57	TARDBP	25	7	32	1116.916
#58	NFXL1	25	10	35	3001.633
#59	TFEB	25	10	35	1172.896
#60	ZEB1	25	10	35	862.905
#61	NFIC	25	9	34	599.287
#62	MNT	25	11	36	1392.15
#63	UBN1	24	1	25	196.255
#64	ADNP	24	10	34	296.155
#65	PHTF1	24	10	34	2102.119
#66	ATF1	24	7	31	386.34
#67	MGA	24	5	29	484.649
#68	HSF1	24	7	31	821.532
#69	PBX1	24	13	37	1630.345
#70	CEBPB	24	13	37	2061.127
#71	GABPA	24	10	34	993.554
#72	ZNF207	24	10	34	2283.868
#73	ZNF236	23	10	33	894.54
#74	SCAND1	23	13	36	2440.91
#75	NFYC	23	8	31	1595.569
#76	TGIF1	23	13	36	580.861
#77	ZNF628	23	10	33	1132.941
#78	SOX10	23	7	30	11187.182
#79	ZEB2	23	4	27	315.081
#80	RCOR1	23	9	32	488.369
#81	IRF6	23	6	29	351.325
#82	ZNF140	23	10	33	429.266
#83	ZBTB48	23	6	29	1465.749
#84	IKZF1	23	4	27	130.177
#85	ESR1	22	17	39	3661.566
#86	STRN3	22	7	29	1334.5
#87	AHCTF1	22	7	29	217.072
#88	YY1	22	7	29	1106.513
#89	NR2C1	22	16	38	1173.891
#90	PGR	22	10	32	7734.482
#91	TRIM25	22	19	41	6499.793
#92	GCFC1	22	11	33	1979.603
#93	TCF19	21	9	30	469.196
#94	ZBTB38	21	15	36	1379.166
#95	RFXANK	21	11	32	801.584
#96	NR2F2	21	15	36	2125.235
#97	YBX1	21	10	31	577.357
#98	RUNX3	21	12	33	1341.724
#99	TAF5	21	14	35	857.787
#100	KLF7	21	13	34	1917.271
#101	TAF4	21	18	39	633.063
#102	ZNF397	21	11	32	815.955
#103	TFCP2	21	8	29	145.318
#104	PLSCR1	21	13	34	5063.504
#105	CSRNP1	20	10	30	1023.294
#106	CREM	20	16	36	894.408
#107	KLF12	20	11	31	2833.28
#108	CBFB	20	9	29	3238.164
#109	ZNF232	20	16	36	2227.13
#110	ZNF193	20	17	37	1553.136
#111	SPIB	20	9	29	2196.201
#112	PBX4	20	10	30	720.093
#113	VAV1	20	10	30	869.503
#114	TAF12	20	10	30	693.517
#115	HMG20A	19	14	33	600.729
#116	CIR1	19	8	27	812.442
#117	ZFPM2	19	14	33	4154.105
#118	GATA6	19	17	36	1568.274
#119	BNC1	19	12	31	490.554
#120	SNAPC5	19	15	34	1696.287
#121	ZNF277	19	9	28	1552.722
#122	ZHX1	19	11	30	696.097
#123	SNAI2	18	12	30	984.464
#124	PBX2	18	7	25	723.19
#125	CCRN4L	18	12	30	1076.627
#126	CBL	18	8	26	844.424
#127	ERG	18	11	29	1712.648
#128	ZSCAN29	18	17	35	1705.267
#129	MTA1	18	11	29	1404.607
#130	LMO4	18	22	40	2342.924
#131	TGIF2	18	17	35	1322.492
#132	LEF1	18	15	33	2580.43
#133	ZNF131	18	16	34	1398.685
#134	GATAD2B	18	5	23	1026.02
#135	GLIS3	18	13	31	407.869
#136	SMAD2	18	11	29	390.498
#137	ETV3	18	9	27	813.652
#138	SOX7	17	15	32	2351.565
#139	EBF1	17	5	22	690.687
#140	SATB1	17	17	34	2784.19
#141	TCF20	17	13	30	2808.557
#142	HOXA10	17	10	27	1326.705
#143	TSC22D1	17	12	29	1245.041
#144	HIF3A	17	7	24	389.691
#145	PRRX1	17	14	31	1278.801
#146	MEF2A	17	16	33	8818.486
#147	JUND	17	8	25	863.581
#148	E2F6	17	14	31	1382.053
#149	FOXP1	17	15	32	1818.182
#150	HOXD13	17	8	25	317.949
#151	NFAT5	17	11	28	3702.072
#152	FOXN2	17	13	30	1362.743
#153	ISL1	17	14	31	998.777
#154	IRF8	17	4	21	105.454
#155	ZRANB2	17	7	24	202.108
#156	ARNT	17	15	32	1386.236
#157	MITF	16	15	31	2016.647
#158	GATAD2A	16	13	29	1433.592
#159	HIRA	16	7	23	528.372
#160	GATAD1	16	17	33	3534.352
#161	ZNF24	16	7	23	1148.059
#162	FOXF2	16	13	29	2664.808
#163	TCF25	16	11	27	720.292
#164	GTF2IRD1	16	12	28	1026.747
#165	SMAD1	16	17	33	3023.099
#166	FOXM1	16	2	18	67.412
#167	NFE2L2	15	13	28	2180.014
#168	SMAD5	15	10	25	599.501
#169	RARA	15	11	26	1852.892
#170	HMGB2	15	9	24	837.587
#171	TFEC	15	12	27	1269.798
#172	BACH1	15	12	27	2631.229
#173	ZNF3	15	11	26	849.155
#174	LHX2	15	20	35	2702.927
#175	BRD8	15	15	30	1182.834
#176	CNOT7	15	15	30	1414.039
#177	EHF	15	18	33	3097.437
#178	TCF3	15	15	30	1603.127
#179	MEF2D	15	9	24	440.569
#180	HLF	15	16	31	2272.718
#181	ZNF93	15	9	24	5004.638
#182	MYNN	15	13	28	681.955
#183	PROX1	15	6	21	899.647
#184	KLF4	15	18	33	2223.852
#185	RERE	15	11	26	1106.444
#186	MECOM	14	18	32	887.839
#187	TRIM29	14	21	35	7399.373
#188	HOXA7	14	12	26	997.593
#189	PRDM1	14	12	26	992.83
#190	ELF3	14	17	31	3022.508
#191	EDF1	14	14	28	564.92
#192	HMGA2	14	12	26	609.608
#193	HOXB7	14	9	23	869.851
#194	AEBP1	14	16	30	1123.609
#195	KLF10	14	13	27	1095.49
#196	NR2F1	14	19	33	2486.009
#197	KDM5B	14	12	26	1613.082
#198	HCLS1	14	6	20	574.373
#199	IRF3	14	11	25	939.167
#200	ZNF70	14	16	30	1704.519
#201	MEF2C	14	9	23	325.659
#202	MEIS1	14	17	31	2230.052
#203	TRIM28	14	12	26	1726.687
#204	MAFK	14	14	28	1107.657
#205	ZKSCAN1	13	12	25	1312.371
#206	FOXN3	13	12	25	505.875
#207	ZSCAN21	13	18	31	756.278
#208	BLZF1	13	14	27	960.822
#209	NR2C2	13	19	32	1736.476
#210	TFDP2	13	17	30	2700.727
#211	RUNX1	13	15	28	1602.65
#212	SCML2	13	19	32	1680.057
#213	RBPJ	13	13	26	349.242
#214	ZNF281	13	13	26	920.437
#215	TCF7	13	7	20	525.457
#216	RORC	13	15	28	1070.674
#217	HDAC1	13	15	28	497.512
#218	ZSCAN18	13	14	27	760.559
#219	ZXDA	13	14	27	748.098
#220	STAT1	12	18	30	2801.799
#221	EGR2	12	12	24	1057.048
#222	TFDP1	12	9	21	488.049
#223	MLL	12	8	20	643.854
#224	UBP1	12	14	26	1527.18
#225	CREBZF	12	16	28	492.954
#226	MEOX2	12	12	24	1356.725
#227	PURA	12	11	23	1231.792
#228	KDM5A	12	12	24	330.79
#229	FOSL1	12	14	26	723.276
#230	ELF2	12	11	23	244.995
#231	FOSL2	12	15	27	2269.005
#232	E2F5	12	11	23	1040.709
#233	TEAD1	12	12	24	571.368
#234	TSHZ3	12	18	30	4061.694
#235	REL	12	12	24	1229.053
#236	ZXDC	12	17	29	1199.238
#237	PCGF2	12	16	28	2392.126
#238	GLI3	12	16	28	1848.435
#239	SOX2	12	23	35	2613.584
#240	DMRT2	11	14	25	2569.408
#241	SP3	11	13	24	895.641
#242	GTF2H2	11	12	23	2092.361
#243	ETV6	11	13	24	605.75
#244	TCF7L2	11	15	26	8580.155
#245	FOXD1	11	16	27	735.618
#246	IRF7	11	12	23	812.718
#247	SLC2A4RG	11	18	29	1740.311
#248	TCFL5	11	14	25	2527.637
#249	ZGPAT	11	9	20	489.468
#250	EGR1	11	3	14	177.568
#251	NR4A1	11	12	23	1679.388
#252	MYCL1	11	13	24	1767.608
#253	HOXA9	11	14	25	1121.699
#254	ETV5	11	18	29	3106.393
#255	HEY1	11	19	30	2836.185
#256	PRDM2	11	8	19	284.479
#257	CREBL2	11	16	27	842.153
#258	CUX1	11	20	31	1817.352
#259	FOXA1	11	21	32	3489.455
#260	RUNX1T1	11	12	23	1298.266
#261	TRIM22	11	9	20	3379.212
#262	TAF7	11	8	19	1773.917
#263	CREB1	11	13	24	1055.621
#264	ELF1	11	11	22	1645.613
#265	BHLHE40	10	15	25	1941.986
#266	LCOR	10	17	27	2741.424
#267	SMAD9	10	15	25	1083.576
#268	HOXD8	10	14	24	714.07
#269	MLLT10	10	11	21	622.709
#270	BTG2	10	17	27	854.944
#271	JUNB	10	12	22	1277.663
#272	ZNF75D	10	10	20	635.843
#273	NR2F6	10	17	27	1559.093
#274	ZNF133	10	9	19	759.491
#275	FOXK1	10	17	27	757.66
#276	PITX2	10	18	28	1259.611
#277	SOX30	10	14	24	1127.653
#278	SIM1	10	8	18	581.131
#279	E2F8	10	11	21	497.73
#280	TFCP2L1	10	20	30	2767.749
#281	SATB2	10	13	23	553.8
#282	ATF7	10	9	19	1672.094
#283	TSHZ1	10	17	27	1206.171
#284	BTAF1	10	10	20	296.727
#285	NFX1	10	15	25	1079.568
#286	FOSB	10	14	24	1279.171
#287	STAT6	10	16	26	313.95
#288	PEG3	10	18	28	3556.358
#289	FLI1	10	7	17	1351.65
#290	MSL3	10	17	27	419.601
#291	CDKN2A	9	18	27	651.416
#292	HOXB3	9	14	23	3589.135
#293	FOXQ1	9	22	31	2338.964
#294	FOXE1	9	25	34	1995.799
#295	ZFP36L2	9	19	28	3574.227
#296	MAFF	9	13	22	3038.762
#297	TWIST1	9	13	22	925.213
#298	ARNTL2	9	17	26	1709.809
#299	RFXAP	9	16	25	1048.323
#300	ZNF91	9	16	25	902.841
#301	MSRB2	9	18	27	815.389
#302	SIM2	9	15	24	2699.092
#303	TULP4	9	10	19	658.128
#304	LASS6	9	18	27	1529.877
#305	DLX2	9	16	25	1594.471
#306	GLIS2	9	14	23	1505.916
#307	CREB3L2	9	19	28	1698.956
#308	SP140	9	7	16	166.261
#309	DRAP1	9	12	21	597.834
#310	DLX6	9	12	21	2880.63
#311	ATF6	9	11	20	3217.068
#312	POU4F1	9	16	25	1168.564
#313	KLF2	9	21	30	957.122
#314	ELF4	9	13	22	724.071
#315	IRX1	9	11	20	1174.442
#316	ATF5	9	17	26	921.637
#317	TAF5L	9	15	24	2553.716
#318	CSDA	9	14	23	1141.566
#319	TAF10	9	13	22	1090.913
#320	AHR	8	18	26	834.384
#321	KLF3	8	17	25	707.51
#322	C5orf41	8	17	25	769.168
#323	PAX6	8	17	25	1824.883
#324	HOXB6	8	12	20	574.875
#325	ASCL2	8	18	26	718.701
#326	NR1D2	8	21	29	431.803
#327	E2F2	8	12	20	493.951
#328	EPAS1	8	19	27	803.776
#329	TRPS1	8	19	27	1020.83
#330	ZNF268	8	18	26	1997.339
#331	ETS1	8	19	27	1142.258
#332	DLX1	8	9	17	938.925
#333	HOXD11	8	15	23	576.658
#334	ZNF167	8	15	23	839.932
#335	NR3C1	8	15	23	847.761
#336	MYC	8	17	25	1935.049
#337	MEIS3P1	8	21	29	941.471
#338	ELK3	8	13	21	404.14
#339	ZFHX3	8	19	27	1516.075
#340	ZSCAN16	8	11	19	257.706
#341	ZIC2	8	23	31	965.935
#342	TP63	8	20	28	2941.196
#343	NKX3-1	8	22	30	1038.113
#344	TFE3	8	18	26	707.955
#345	ELF5	8	20	28	3146.201
#346	HOXD10	8	9	17	843.485
#347	NFIB	8	24	32	2038.469
#348	NANOGNB	8	9	17	188.281
#349	SLC30A9	8	15	23	293.195
#350	MEIS2	8	17	25	694.866
#351	XBP1	8	15	23	741.857
#352	MYCN	8	12	20	934.5
#353	HOXC10	8	14	22	555.242
#354	FOS	8	13	21	542.514
#355	CTBP1	7	13	20	499.804
#356	GAS7	7	19	26	1177.054
#357	LHX8	7	20	27	570.208
#358	GTF2H3	7	9	16	164.587
#359	CSRNP3	7	16	23	1729.32
#360	FOXK2	7	15	22	1458.579
#361	ZNF323	7	18	25	1572.18
#362	HNF4G	7	21	28	1335.312
#363	KLF5	7	17	24	580.785
#364	RUNX2	7	13	20	363.164
#365	HOXA1	7	19	26	1459.624
#366	RORB	7	12	19	4065.751
#367	HMBOX1	7	20	27	1889.147
#368	NKX2-3	7	12	19	765.637
#369	EGR4	7	17	24	1306.724
#370	NFIL3	7	17	24	454.076
#371	RCAN1	7	20	27	618.851
#372	ZNF256	7	12	19	365.621
#373	VDR	7	19	26	1077.438
#374	NR3C2	7	15	22	1487.499
#375	CBFA2T2	7	19	26	693.199
#376	SREBF1	7	17	24	579.287
#377	HMGB1	7	13	20	744.931
#378	NFATC3	7	15	22	2316.021
#379	EGR3	7	19	26	1136.971
#380	CEBPD	6	15	21	342.597
#381	ZNF217	6	15	21	1686.128
#382	IRF2	6	16	22	361.834
#383	ETV7	6	16	22	992.185
#384	FBXW7	6	17	23	1179.709
#385	STAT3	6	20	26	928.517
#386	NR4A3	6	24	30	1455.997
#387	L3MBTL4	6	12	18	878.816
#388	TP53	6	20	26	1117.787
#389	ZIC1	6	15	21	2228.571
#390	HOXA5	6	17	23	2868.169
#391	FOXO6	6	18	24	1285.77
#392	NOTCH1	6	17	23	1346.27
#393	TFAP2A	6	16	22	1156.756
#394	TSHZ2	6	13	19	1117.991
#395	PTTG1	6	13	19	393.258
#396	BACH2	6	16	22	550.237
#397	MAFB	6	21	27	928.561
#398	SP1	6	18	24	1146.454
#399	HOXA13	6	11	17	824.338
#400	KLF9	6	16	22	753.565
#401	BATF2	6	12	18	906.718
#402	ETS2	6	21	27	1057.211
#403	HES1	6	17	23	412.367
#404	BHLHE41	6	22	28	2215.784
#405	ZNF165	6	16	22	1788.612
#406	WNT5A	6	20	26	1786.88
#407	ATF3	6	16	22	1634.317
#408	RBCK1	6	17	23	676.987
#409	ZNF37A	6	14	20	760.799
#410	STAT2	6	14	20	326.235
#411	ZC3H8	5	18	23	687.356
#412	TCF4	5	16	21	349.76
#413	ZNF83	5	25	30	3219.009
#414	THRB	5	23	28	2169.743
#415	GLI2	5	13	18	692.368
#416	FOXF1	5	19	24	498.226
#417	FOXP2	5	22	27	3964.308
#418	C1orf85	5	27	32	535.75
#419	HMG20B	5	13	18	304.142
#420	BCL11B	5	18	23	1899.676
#421	CBFA2T3	5	11	16	435.12
#422	LZTS1	5	12	17	1596.041
#423	NFYA	5	19	24	762.078
#424	IRX2	5	19	24	838.893
#425	ZHX2	5	20	25	781.609
#426	SOX6	5	19	24	1204.412
#427	FOXC2	5	17	22	1347.881
#428	TAF4B	5	16	21	394.147
#429	FOXO3	5	19	24	699.28
#430	KLF11	5	17	22	223.141
#431	ZNF189	5	19	24	450.768
#432	AFF4	5	14	19	705.808
#433	BUD31	4	11	15	82.337
#434	HOXA2	4	20	24	684.064
#435	TBX3	4	15	19	419.051
#436	ZNF92	4	16	20	220.795
#437	PPARA	4	13	17	574.05
#438	TSC22D2	4	24	28	2015.224
#439	NPAT	4	17	21	487.577
#440	KLF6	4	19	23	538.365
#441	SMAD3	4	14	18	248.394
#442	PLAG1	4	19	23	560.913
#443	PLAGL2	4	18	22	509.024
#444	GATA2	4	20	24	474.327
#445	SP4	4	16	20	431.174
#446	PURB	4	20	24	642.154
#447	CTNNB1	4	22	26	758.257
#448	JDP2	4	8	12	77.267
#449	SIX2	4	16	20	257.222
#450	IRF1	4	16	20	728.399
#451	ZFP36L1	4	17	21	655.226
#452	IRF9	4	17	21	555.399
#453	BCL6	4	15	19	384.389
#454	PITX1	4	19	23	286.075
#455	NR0B1	4	6	10	618.78
#456	NFE2L1	4	17	21	611.215
#457	TWIST2	4	18	22	752.835
#458	ESRRG	4	12	16	437.07
#459	RB1	4	14	18	3224.348
#460	ZFP90	4	15	19	280.515
#461	FOXL2	4	17	21	531.596
#462	PA2G4	3	14	17	71.994
#463	RXRA	3	19	22	389.685
#464	IRX4	3	16	19	462.864
#465	CREB3	3	16	19	1130.053
#466	CREB5	3	21	24	2311.783
#467	MAF	3	21	24	370.673
#468	PBX3	3	15	18	221.266
#469	TEF	3	17	20	385.329
#470	NFATC1	3	20	23	450.019
#471	TCF12	3	26	29	1904.402
#472	FOXO1	3	13	16	145.233
#473	HOXB2	3	19	22	180.929
#474	NPAS2	3	22	25	1410.298
#475	MEOX1	3	16	19	506.575
#476	DMRT1	3	17	20	904.614
#477	HMGA1	3	15	18	134.519
#478	SOX9	3	28	31	2260.915
#479	TCF7L1	3	16	19	787.391
#480	NFIA	3	19	22	801.262
#481	NR4A2	3	23	26	338.458
#482	BCL3	2	17	19	162.647
#483	ZNF138	2	15	17	259.762
#484	TP73	2	20	22	931.036
#485	PAX3	2	13	15	215.853
#486	POU2F3	2	16	18	178.836
#487	FOXC1	2	23	25	590.999
#488	GATA3	2	20	22	592.767
#489	TSC22D3	2	17	19	240.186
#490	MBD1	2	19	21	367.903
#491	JUN	2	16	18	181.43
#492	RORA	1	17	18	109.226
#493	CITED2	1	23	24	154.99
#494	WT1	1	17	18	1190.79
#495	FOXG1	1	10	11	36.056
#496	TRERF1	1	15	16	42.632
#497	ZFP42	0	17	17	0
#498	ZNF117	0	22	22	0
#499	IRF5	0	22	22	0
#500	IRX3	0	22	22	0