Hub Rank	Node	Children	Parents	Degree	Betweenness
#1	IRF2	43	2	45	2815.126
#2	ATF1	38	6	44	1438.197
#3	RARG	36	3	39	707.071
#4	ATF2	35	5	40	1071.333
#5	ELK1	33	8	41	15150.822
#6	FOXJ3	32	10	42	3715.639
#7	TAF4	31	7	38	517.301
#8	HMX1	31	2	33	286.205
#9	RELB	30	5	35	359.397
#10	SOX15	30	2	32	1648.897
#11	MLXIPL	29	1	30	258.679
#12	SNAPC2	29	5	34	176.738
#13	ADNP	29	11	40	2393.756
#14	NFE2L2	28	6	34	1666.879
#15	MGA	27	7	34	2590.771
#16	MAFF	26	11	37	3613.07
#17	MYOG	26	5	31	927.84
#18	PHF1	26	9	35	1569.347
#19	SP3	26	8	34	1360.512
#20	RELA	26	9	35	5160.416
#21	ZKSCAN1	25	7	32	1449.74
#22	PRRX2	25	7	32	4919.872
#23	RCOR1	24	9	33	2604.583
#24	ETV4	24	5	29	342.871
#25	ZNF189	24	8	32	1672.866
#26	PITX3	24	2	26	54.438
#27	CREBZF	23	10	33	748.015
#28	ZNF140	23	13	36	2481.523
#29	NPAT	23	6	29	20167.082
#30	NFYC	22	10	32	1457.357
#31	BLZF1	22	5	27	737.081
#32	ELK3	22	10	32	3567.019
#33	IRF3	22	5	27	1145.133
#34	TCF15	22	5	27	5588.553
#35	HDAC2	22	9	31	641.573
#36	NCOR1	21	5	26	8894.032
#37	HSF4	21	8	29	2922.667
#38	SOX21	21	9	30	1969.394
#39	ZNF444	21	6	27	236.672
#40	ZNF202	21	11	32	1026.21
#41	HNF1B	21	4	25	252.187
#42	TFE3	21	10	31	1553.672
#43	REST	21	6	27	8283.596
#44	FLI1	21	6	27	3165.382
#45	TCF12	21	5	26	772.711
#46	HNRNPAB	21	9	30	1318.975
#47	CTCF	21	8	29	311.162
#48	ELF3	21	11	32	9158.438
#49	KLF9	20	9	29	599.234
#50	TRIM28	20	10	30	1089.476
#51	ECSIT	20	4	24	1968.914
#52	SNAPC5	20	9	29	8475.449
#53	FOXO4	20	2	22	24.297
#54	ZNF217	20	8	28	2540.19
#55	TFAP2C	19	7	26	4848.874
#56	RXRB	19	7	26	2982.583
#57	TAF5	19	10	29	1650.738
#58	SMAD6	19	8	27	428.109
#59	TBX4	19	5	24	189.223
#60	RAX	19	7	26	3317.575
#61	ETV7	19	6	25	2665.42
#62	PKNOX2	19	6	25	571.761
#63	AHR	18	11	29	3202.585
#64	RORC	18	1	19	12.011
#65	TP53	18	11	29	1507.4
#66	TFCP2	18	10	28	2815.338
#67	ETV6	18	9	27	1515.615
#68	TFAM	17	12	29	1481.1
#69	NR1H2	17	12	29	1087.13
#70	HMG20A	17	7	24	1702.438
#71	NR3C1	17	8	25	645.093
#72	ATF4	17	9	26	599.501
#73	BACH1	17	12	29	2270.897
#74	IRF1	17	10	27	1151.584
#75	E2F3	17	12	29	1687.83
#76	EVX1	16	9	25	3121.608
#77	ZNF232	16	11	27	1197.611
#78	MEF2C	16	9	25	15843.548
#79	HINFP	16	8	24	563.46
#80	FOXJ1	16	6	22	1371.853
#81	MLX	16	8	24	2514.099
#82	RFXANK	16	7	23	1336.353
#83	HIF3A	16	6	22	1921.218
#84	TAF12	16	11	27	1338.313
#85	FOXP3	16	7	23	462.057
#86	POU5F1B	16	9	25	1101.439
#87	PAX8	16	5	21	471.777
#88	E2F4	16	7	23	849.408
#89	E2F6	16	12	28	865.225
#90	BHLHE41	16	15	31	4146.922
#91	PBX2	16	8	24	166.877
#92	ESRRA	15	8	23	996.119
#93	ELK4	15	10	25	4334.349
#94	ATF6B	15	13	28	1181.241
#95	HNRNPK	15	7	22	1329.426
#96	TSC22D2	15	8	23	919.686
#97	SMAD4	15	9	24	481.275
#98	SMAD2	15	11	26	3053.802
#99	CBFA2T3	15	11	26	10428.144
#100	MMP14	15	6	21	2119.573
#101	KLF6	15	11	26	2260.006
#102	NFYA	15	9	24	672.124
#103	BTAF1	15	13	28	3079.756
#104	TCF20	15	6	21	2058.014
#105	NPAS1	15	10	25	17575.658
#106	CREB3L1	14	4	18	1280.13
#107	EPAS1	14	12	26	3434.418
#108	STAT3	14	12	26	6903.357
#109	MEF2A	14	9	23	1845.211
#110	FUBP1	14	9	23	1678.841
#111	RUNX1	14	12	26	4154.384
#112	FOXO1	14	11	25	1657.381
#113	NFYB	14	13	27	2898.13
#114	UBP1	14	11	25	1029.754
#115	ZNF75D	14	6	20	281.008
#116	ZNF236	14	5	19	4102.601
#117	STRN3	14	7	21	3754.462
#118	PRDM2	14	9	23	921.042
#119	ELF2	14	11	25	994.998
#120	GABPA	14	10	24	1145.884
#121	HSF2	14	9	23	935.376
#122	CDX2	14	6	20	105.481
#123	ETS2	14	13	27	3363.465
#124	HOXB1	14	10	24	425.645
#125	PHTF1	13	14	27	3127.76
#126	PTTG1	13	10	23	1495.359
#127	MAFG	13	8	21	1283.552
#128	ARID4A	13	8	21	1630.944
#129	HNF1A	13	7	20	192.585
#130	ZBTB38	13	5	18	319.939
#131	PCGF2	13	3	16	63.772
#132	RB1	13	12	25	1800.919
#133	EDF1	13	11	24	732.178
#134	ADNP2	13	12	25	1710.225
#135	NPAS2	13	11	24	672.076
#136	ZKSCAN5	13	10	23	1701.58
#137	MYNN	13	14	27	843.614
#138	FOSB	13	5	18	978.913
#139	SOX13	13	6	19	1834.797
#140	TCEAL1	12	10	22	1363.364
#141	MITF	12	6	18	1333.798
#142	ARNTL	12	12	24	2749.811
#143	SPDEF	12	9	21	796.018
#144	GTF2I	12	8	20	1280.618
#145	NKX2-5	12	10	22	9898.211
#146	LZTS1	12	7	19	711.917
#147	TAF5L	12	9	21	1715.591
#148	MAF	12	14	26	2056.324
#149	CDKN2A	12	10	22	1348.009
#150	SIX5	12	6	18	93.802
#151	BARX1	12	7	19	1791.385
#152	MLL	12	12	24	2602.56
#153	FOSL2	12	9	21	2642.356
#154	SOX10	12	9	21	3373.031
#155	SLC2A4RG	12	12	24	1684.056
#156	ZNF394	12	8	20	2363.94
#157	ZNF643	12	8	20	1449.896
#158	NR1I2	12	10	22	393.676
#159	BATF	12	7	19	776.169
#160	MYBL2	11	10	21	417.617
#161	ZNF219	11	9	20	687.894
#162	IRF6	11	3	14	194.865
#163	LHX3	11	11	22	2496.925
#164	HAND2	11	7	18	297.598
#165	BCL3	11	10	21	331.547
#166	REL	11	8	19	2480.044
#167	PAX7	11	9	20	493.907
#168	USF2	11	12	23	1082.182
#169	GATA2	11	8	19	14997.731
#170	LASS6	11	9	20	1120.472
#171	FOXJ2	11	8	19	911.139
#172	IRF8	11	12	23	2465.32
#173	CREBBP	11	13	24	680.115
#174	CBFB	11	10	21	1164.718
#175	MEF2D	11	10	21	792.908
#176	NR1D2	11	13	24	2066.702
#177	ZNF165	10	15	25	2664.329
#178	FOXM1	10	5	15	771.742
#179	DMTF1	10	14	24	2992.697
#180	POU2F2	10	9	19	2164.137
#181	ZFP36L1	10	15	25	1929.999
#182	TARDBP	10	12	22	2006.169
#183	RXRA	10	10	20	1161.546
#184	ZNF268	10	5	15	733.784
#185	FOXL1	10	8	18	1011.61
#186	ZNF175	10	8	18	902.353
#187	POU6F1	10	8	18	350.032
#188	HMGA1	10	11	21	1200.572
#189	SIX1	10	10	20	186.333
#190	STAT2	10	7	17	681.184
#191	BUD31	10	12	22	1731.693
#192	GTF2H3	10	11	21	2333.798
#193	ZSCAN16	10	9	19	766.068
#194	KLF10	10	13	23	2396.898
#195	MZF1	10	13	23	1067.797
#196	ZNF133	10	10	20	792.085
#197	MAFB	10	11	21	1622.014
#198	NKX2-8	10	10	20	263.013
#199	RFX5	10	8	18	1905.99
#200	TCF25	10	14	24	2689.475
#201	KLF2	10	8	18	542.336
#202	ZNF167	10	8	18	1976.188
#203	HOXA5	9	9	18	3922.069
#204	SPI1	9	11	20	732.992
#205	NOLC1	9	16	25	800.434
#206	EGR4	9	6	15	8388.905
#207	ZNF3	9	8	17	944.606
#208	SNAPC4	9	13	22	1852.457
#209	CUX1	9	11	20	1888.607
#210	KLF3	9	13	22	1069.654
#211	ELF1	9	9	18	667.212
#212	NFKB1	9	6	15	1142.739
#213	NR2E3	9	9	18	476.38
#214	BACH2	9	13	22	1161.778
#215	GLI3	9	6	15	692.858
#216	NFAT5	9	10	19	1150.871
#217	BATF3	9	9	18	876.213
#218	RUNX3	9	13	22	1299.425
#219	TBX2	9	5	14	449.022
#220	FOXN3	9	11	20	1391.784
#221	IRF7	9	7	16	626.032
#222	KLF11	9	11	20	1252.853
#223	RERE	9	14	23	2672.129
#224	E2F8	9	6	15	1249.814
#225	CSRNP3	9	8	17	313.924
#226	MAX	9	14	23	1058.098
#227	VDR	9	15	24	3314.103
#228	ZNF131	9	10	19	3700.026
#229	RARB	9	10	19	515.173
#230	ZNF83	9	11	20	824.013
#231	YY1	9	17	26	860.564
#232	SPIB	9	9	18	2785.48
#233	TCF4	9	19	28	4645.653
#234	TSC22D4	9	8	17	708.701
#235	HOPX	9	10	19	2334.021
#236	GSC2	9	6	15	2208.004
#237	ZNF187	9	12	21	885.425
#238	TFAP4	9	9	18	123.251
#239	ZNF24	9	11	20	584.472
#240	ZFHX3	9	12	21	1719.741
#241	NR4A1	9	9	18	3263.996
#242	HEY2	9	14	23	9187.699
#243	ZNF434	8	10	18	767.977
#244	NFE2L3	8	11	19	1421.642
#245	ETV5	8	11	19	3381.651
#246	NFATC3	8	7	15	615.748
#247	KDM5B	8	10	18	2175.058
#248	IRF9	8	5	13	390.95
#249	ZEB1	8	12	20	1437.497
#250	PBX1	8	7	15	757.713
#251	NR2C1	8	12	20	820.33
#252	HCLS1	8	13	21	951.953
#253	TCFL5	8	13	21	2142.101
#254	HOXD1	8	13	21	2025.842
#255	FOXO3	8	13	21	2179.606
#256	CREB1	8	8	16	6708.122
#257	GATAD1	8	10	18	1021.012
#258	LASS2	8	15	23	1251.361
#259	PLAGL2	8	16	24	3389.755
#260	TGIF2	8	9	17	287.832
#261	HOXB7	8	12	20	1488.642
#262	DLX2	8	11	19	233.269
#263	IKZF1	8	12	20	671.692
#264	ESR1	8	13	21	3198.008
#265	IKZF3	8	13	21	482.818
#266	HMGB2	8	17	25	1988.322
#267	MSC	8	11	19	406.961
#268	CSRNP2	8	5	13	514.047
#269	STAT1	8	13	21	657.787
#270	SOX9	8	9	17	1666.251
#271	HOXA3	8	7	15	300.316
#272	NR3C2	8	7	15	628.441
#273	SOX4	8	16	24	1797.371
#274	PFDN1	8	9	17	658.863
#275	PPARD	8	10	18	514.735
#276	KLF4	8	15	23	1817.519
#277	TFCP2L1	8	8	16	635.405
#278	CEBPE	8	5	13	60.983
#279	PITX1	8	9	17	1232.759
#280	TEF	8	6	14	936.973
#281	GTF2IRD1	8	8	16	1371.567
#282	CBFA2T2	8	9	17	1278.18
#283	NFATC4	8	7	15	590.833
#284	ONECUT2	8	7	15	3364.419
#285	LMO4	8	13	21	1287.903
#286	E2F5	8	14	22	1394.493
#287	TCF3	8	9	17	5397.297
#288	STAT5B	7	8	15	824.256
#289	RBCK1	7	10	17	1270.752
#290	SMAD3	7	13	20	1425.538
#291	NFATC1	7	15	22	4249.223
#292	RARA	7	15	22	2762.583
#293	ZKSCAN4	7	11	18	938.439
#294	CLOCK	7	11	18	1647.135
#295	RCAN1	7	10	17	599.166
#296	AHCTF1	7	12	19	1447.296
#297	RORA	7	19	26	2072.034
#298	CREBL2	7	15	22	1551.927
#299	GCFC1	7	8	15	3074.042
#300	HR	7	7	14	92.597
#301	SCML1	7	14	21	3470.199
#302	FOXK2	7	12	19	1229.542
#303	SP140	7	10	17	1423.61
#304	EMX1	7	7	14	800.346
#305	FOXA2	7	7	14	117.291
#306	POU4F1	7	10	17	933.697
#307	HDAC1	7	12	19	572.372
#308	ATF6	7	15	22	1099.087
#309	ELF4	7	11	18	1086.42
#310	HEY1	7	13	20	1211.427
#311	TAF4B	7	17	24	2044.869
#312	SALL2	7	12	19	16360.22
#313	TCF7L2	7	10	17	1305.907
#314	CREB5	7	7	14	961.596
#315	HOXC4	7	12	19	996.558
#316	NOTCH1	7	8	15	272.775
#317	ZNF117	7	10	17	891.974
#318	ZNF323	7	10	17	5648.628
#319	SUPT6H	7	13	20	544.798
#320	TULP4	7	9	16	814.865
#321	ZHX2	7	15	22	1488.144
#322	GTF2H4	7	10	17	424.323
#323	SATB2	7	10	17	1539.353
#324	LZTR1	7	8	15	295.003
#325	ZNF281	7	12	19	1205.36
#326	ETV2	7	11	18	804.506
#327	ATF3	7	7	14	419.622
#328	FOS	7	10	17	1283.427
#329	TFDP1	7	13	20	2316.258
#330	EGR3	6	13	19	1247.273
#331	MTA1	6	11	17	481.434
#332	STAT6	6	10	16	4082.523
#333	DDIT3	6	13	19	978.475
#334	C2orf3	6	8	14	2215.922
#335	ZNF238	6	15	21	564.665
#336	HIC1	6	6	12	253.559
#337	ESRRG	6	13	19	713.357
#338	ZNF45	6	11	17	262.724
#339	POU2F1	6	9	15	793.309
#340	MEIS3P1	6	9	15	621.113
#341	KDM5A	6	11	17	1499.919
#342	NFKB2	6	12	18	845.234
#343	NFIC	6	13	19	1201.554
#344	ZSCAN18	6	10	16	964.827
#345	NFIB	6	13	19	1866.365
#346	NR4A2	6	12	18	1547.649
#347	HMG20B	6	12	18	3024.601
#348	IRF5	6	10	16	687.451
#349	ATF5	6	15	21	1237.61
#350	ZFPM2	6	6	12	833.916
#351	PLAG1	6	13	19	1662.598
#352	NEUROD2	6	8	14	1501.011
#353	CREB3L2	6	16	22	1992.977
#354	TRPS1	6	7	13	758.861
#355	BRD8	6	7	13	947.094
#356	RBPJ	6	13	19	316.589
#357	HES1	6	10	16	1943.412
#358	HOXA9	6	8	14	544.017
#359	NRL	6	12	18	1343.165
#360	PAX4	6	13	19	187.302
#361	PA2G4	6	7	13	1282.373
#362	JUND	6	8	14	163.854
#363	BCL6	5	10	15	1144.973
#364	ZNF193	5	13	18	2281.203
#365	TCF7	5	7	12	261.552
#366	ERF	5	8	13	281.053
#367	SOLH	5	13	18	975.607
#368	ZFP36L2	5	12	17	1088.253
#369	HOXB2	5	9	14	3744.658
#370	TBP	5	15	20	2082.92
#371	CIR1	5	14	19	978.342
#372	IRF4	5	12	17	510.581
#373	JUNB	5	15	20	2757.154
#374	LEF1	5	12	17	1225.364
#375	MYC	5	15	20	1216.753
#376	PRDM1	5	6	11	329.315
#377	HOXC11	5	10	15	320.006
#378	FOXN1	5	7	12	84.851
#379	TFAP2A	5	6	11	1306.911
#380	EGR1	5	8	13	547.959
#381	ARNT2	5	11	16	1149.123
#382	SLC30A9	5	8	13	313.533
#383	MLLT10	5	13	18	985.848
#384	CEBPD	5	14	19	2505.368
#385	HOXC10	5	8	13	518.157
#386	AFF4	5	12	17	1903.29
#387	ZNF274	5	17	22	1266.353
#388	PURA	5	14	19	1062.573
#389	TAF10	5	15	20	1220.137
#390	CITED2	5	12	17	1497.532
#391	CNOT8	5	12	17	923.347
#392	TFDP2	5	6	11	486.18
#393	JUN	5	8	13	503.822
#394	MYT1L	5	8	13	778.533
#395	NFE2L1	5	14	19	1863.913
#396	MXD1	5	11	16	895.706
#397	NFX1	5	10	15	943.884
#398	SPEN	5	12	17	1998.896
#399	MNT	5	9	14	531.365
#400	ZBTB48	5	15	20	507.717
#401	TP73	5	8	13	212.014
#402	TSC22D3	5	10	15	594.85
#403	RNF4	5	12	17	907.218
#404	HOXA10	4	12	16	1608.534
#405	ENO1	4	13	17	836.781
#406	CNOT7	4	11	15	728.526
#407	FBXW7	4	15	19	811.906
#408	GAS7	4	7	11	989.244
#409	FOXA1	4	9	13	506.519
#410	NFE2	4	7	11	510.247
#411	SREBF2	4	11	15	528.005
#412	ZNF148	4	10	14	501.059
#413	CREM	4	13	17	705.582
#414	ZNF174	4	13	17	5634.844
#415	HOXA1	4	6	10	186.772
#416	SMAD5	4	7	11	996.973
#417	TFEC	4	15	19	1563.132
#418	SATB1	4	10	14	570.488
#419	ZNF93	4	11	15	1632.658
#420	MYF6	4	9	13	2120.222
#421	SOX12	4	8	12	490.636
#422	GABPB1	4	15	19	1640.231
#423	YBX1	4	11	15	1486.678
#424	TADA3	4	8	12	433.383
#425	SCAND1	4	9	13	234.59
#426	HIF1A	4	18	22	1434.546
#427	HEYL	4	8	12	113.999
#428	STAT4	4	13	17	728.011
#429	MBD1	3	10	13	374.325
#430	DRAP1	3	9	12	454.396
#431	HNF4A	3	8	11	198.008
#432	CSDA	3	20	23	980.314
#433	MSL3	3	20	23	560.869
#434	ZNF91	3	15	18	892.243
#435	RUNX1T1	3	13	16	940.258
#436	TSHZ2	3	8	11	43.046
#437	PLSCR1	3	10	13	219.332
#438	ZNF207	3	9	12	2086.701
#439	HOXC8	3	8	11	143.819
#440	MSRB2	3	16	19	1281.213
#441	TAF7	3	11	14	1034.438
#442	KLF7	3	14	17	326.263
#443	ZGPAT	3	10	13	258.557
#444	XBP1	3	14	17	1927.08
#445	MYCN	3	8	11	891.29
#446	HMGB1	3	15	18	606.48
#447	NFIL3	3	8	11	625.89
#448	HMBOX1	3	10	13	260.228
#449	SIX2	3	8	11	305.545
#450	SRF	3	11	14	454.441
#451	HSF1	3	12	15	533.621
#452	NR4A3	3	9	12	836.922
#453	TRIM22	3	15	18	815.742
#454	FOXN2	3	9	12	213.737
#455	CTBP1	3	14	17	317.027
#456	UBN1	3	14	17	885.665
#457	FOXD1	3	8	11	287.971
#458	ZNF215	3	8	11	295.007
#459	ATOH1	3	9	12	296.682
#460	VAV1	3	7	10	1396.15
#461	SOX2	3	6	9	372.899
#462	KLF5	3	13	16	966.278
#463	HIRA	3	13	16	276.309
#464	CEBPB	3	14	17	288.592
#465	ZNF134	2	13	15	321.521
#466	NR2F6	2	11	13	228.945
#467	PBX3	2	14	16	248.522
#468	ZBTB25	2	10	12	553.014
#469	TAF6	2	15	17	618.534
#470	TBX21	2	12	14	646.076
#471	SMAD1	2	16	18	253.274
#472	CREB3	2	12	14	366.088
#473	NKX3-1	2	9	11	159.944
#474	SOX11	2	9	11	917.421
#475	ARNTL2	2	11	13	527.455
#476	MEIS2	2	15	17	1163.78
#477	THRA	2	10	12	1582.701
#478	TSC22D1	2	19	21	1665.161
#479	ZNF277	2	13	15	169.406
#480	GATA3	2	10	12	413.997
#481	TGIF1	2	9	11	248.84
#482	CTNNB1	2	8	10	126.063
#483	ARID3A	2	11	13	184.748
#484	PEG3	2	11	13	1555.507
#485	CNBP	2	10	12	324.52
#486	PPARA	2	12	14	988.147
#487	WNT5A	1	16	17	239.145
#488	BHLHE40	1	19	20	580.255
#489	AFF1	1	17	18	150.53
#490	SUPT4H1	1	11	12	425.368
#491	TFEB	1	11	12	410.51
#492	PAX6	1	8	9	83.926
#493	BTG2	1	15	16	385.522
#494	HHEX	1	10	11	263.895
#495	ETV1	1	15	16	224.909
#496	NR5A1	1	8	9	33.533
#497	ESR2	0	12	12	0
#498	SREBF1	0	15	15	0
#499	AEBP1	0	8	8	0
#500	EGR2	0	11	11	0