Hub Rank	Node	Children	Parents	Degree	Betweenness
#1	FOXA1	111	1	112	545.643
#2	YBX1	100	11	111	244.361
#3	FOXC1	97	1	98	8.515
#4	FOXM1	89	10	99	1965.462
#5	GATA3	87	4	91	273.749
#6	MZF1	87	4	91	40.134
#7	XBP1	84	9	93	277.133
#8	ESR1	82	4	86	143.077
#9	E2F3	81	17	98	588.664
#10	SPDEF	81	7	88	187.631
#11	TAF4B	80	7	87	1395.565
#12	SOX10	78	3	81	873.261
#13	FOXP1	77	16	93	1386.683
#14	NFE2L3	77	9	86	984.694
#15	AFF1	73	18	91	2932.672
#16	RERE	69	11	80	458.642
#17	EN1	68	8	76	303.391
#18	ELF5	67	8	75	350.288
#19	PTTG1	66	19	85	1155.941
#20	BHLHE40	66	14	80	3964.623
#21	LMO4	66	15	81	723.1
#22	GLI3	61	6	67	620.901
#23	GAS7	61	8	69	5110.558
#24	NFATC4	60	10	70	346.097
#25	ARNTL2	60	10	70	2010.079
#26	HNF4A	59	3	62	221.884
#27	SOX6	58	12	70	834.673
#28	MAFK	58	13	71	395.381
#29	ZEB1	58	4	62	1115.544
#30	HMGA1	58	25	83	5042.135
#31	FOSB	57	2	59	18.359
#32	CSRNP1	57	0	57	0
#33	SOX8	56	3	59	9.8
#34	SP1	56	11	67	159.11
#35	ENO1	56	25	81	1743.734
#36	ZNF215	56	3	59	38.54
#37	BTG2	56	7	63	251.796
#38	EBF1	55	4	59	477.643
#39	FOXN2	55	16	71	1398.745
#40	TFDP3	54	2	56	3007.612
#41	TEAD4	53	18	71	2158.483
#42	L3MBTL4	53	12	65	840.087
#43	ZFHX3	53	17	70	3311.868
#44	KDM5B	52	21	73	1690.417
#45	HCFC1	51	6	57	368.804
#46	HDAC2	51	27	78	4125.886
#47	JUN	50	9	59	133.354
#48	NRL	50	3	53	183.671
#49	TSHZ1	50	21	71	1151.039
#50	SUPT6H	50	18	68	820.329
#51	MEF2C	49	24	73	2468.636
#52	MEF2D	49	17	66	299.652
#53	BRD8	49	14	63	384.848
#54	E2F5	49	14	63	788.833
#55	ETV6	49	16	65	1602.963
#56	PHF1	49	24	73	906.767
#57	GATA4	49	1	50	4.473
#58	NFIA	48	12	60	377.54
#59	PBX1	48	16	64	294.13
#60	GTF2I	48	19	67	900.074
#61	RFX1	48	12	60	812.591
#62	NFKB2	47	16	63	1092.904
#63	AFF4	47	17	64	383.465
#64	TCF19	47	14	61	215.969
#65	SPIB	46	9	55	2419.925
#66	ZNF396	45	3	48	184.449
#67	NR1I3	45	8	53	51.015
#68	NR4A1	45	1	46	2.119
#69	ZNF367	45	13	58	1232.885
#70	CBFA2T2	45	17	62	1800.241
#71	ZNF445	44	6	50	37.082
#72	TCEAL1	44	19	63	4879.524
#73	EGR3	44	5	49	92.823
#74	CDKN2A	43	22	65	578.171
#75	ELF2	43	7	50	90.902
#76	NFIB	43	25	68	580.197
#77	NOTCH1	43	17	60	901.324
#78	AR	43	17	60	290.559
#79	LASS5	43	10	53	236.556
#80	RUNX1T1	42	4	46	1823.825
#81	TCF7L1	42	15	57	1356.545
#82	MYC	42	21	63	448.845
#83	E2F4	42	11	53	682.939
#84	PAX8	41	8	49	618.782
#85	CEBPB	41	29	70	1743.469
#86	SOX2	41	19	60	1725.704
#87	SIX3	41	8	49	141.406
#88	ELK3	41	11	52	469.422
#89	MYCN	40	21	61	1153.722
#90	SOX11	39	26	65	5221.534
#91	DMTF1	39	22	61	697.789
#92	TRIM28	39	29	68	1529.444
#93	JUND	39	22	61	1295.419
#94	IKZF1	38	1	39	29.989
#95	C5orf41	38	17	55	454.931
#96	ZNF500	38	15	53	294.281
#97	CREBBP	38	29	67	873.129
#98	IRF8	38	4	42	362.08
#99	HOXC9	38	18	56	642.199
#100	MBD1	37	24	61	599.312
#101	TCF4	37	6	43	208.28
#102	ZEB2	37	19	56	719.248
#103	ATF5	37	25	62	1456.053
#104	SMAD2	37	22	59	827.891
#105	KLF2	36	18	54	1591.255
#106	SMAD4	36	20	56	242.789
#107	PLSCR1	36	26	62	536.451
#108	RUNX3	36	22	58	4266.064
#109	CREB3L3	36	16	52	11002.668
#110	NR2F1	36	21	57	4315.143
#111	ZNF639	36	28	64	1064.309
#112	TFAM	36	17	53	1020.004
#113	FOS	36	7	43	123.812
#114	RUNX1	35	26	61	739.762
#115	TFDP1	35	23	58	1290.565
#116	ZNF207	35	20	55	676.939
#117	ZSCAN12	35	10	45	3648.791
#118	ETS1	35	14	49	969.346
#119	ATF3	35	9	44	190.995
#120	E2F1	34	13	47	806.031
#121	NFIC	34	21	55	1110.547
#122	ZNF24	34	28	62	924.486
#123	SIN3A	34	19	53	322.642
#124	HCLS1	34	7	41	91.627
#125	ZNF449	34	14	48	1412.601
#126	RXRA	34	27	61	629.498
#127	SOX12	34	29	63	2202.148
#128	SLC2A4RG	34	20	54	676.095
#129	SPEN	34	13	47	190.267
#130	ZNF93	34	18	52	2109.774
#131	GATAD2A	34	25	59	708.404
#132	CREB3L4	34	19	53	1003.211
#133	GTF2IRD1	34	26	60	1145.787
#134	TP53	33	35	68	2657.827
#135	HOXC10	33	19	52	1307.102
#136	RCAN1	33	32	65	2318.377
#137	MSL3	33	20	53	738.003
#138	PURA	33	23	56	927.397
#139	RUNX2	33	5	38	712.259
#140	TCF20	33	34	67	710.614
#141	TCF3	33	25	58	1062.312
#142	KLF5	33	16	49	351.992
#143	KLF3	33	24	57	1096.687
#144	RELB	32	19	51	573.983
#145	ZIC1	32	27	59	802.519
#146	SALL2	32	26	58	1430.669
#147	MLL	32	12	44	334.221
#148	RORA	32	15	47	542.986
#149	FOXO1	32	8	40	204.85
#150	ZNF85	32	10	42	313.033
#151	ELK1	31	14	45	400.694
#152	THRA	31	9	40	8272.663
#153	ZNF236	31	10	41	1112.959
#154	MITF	31	11	42	138.114
#155	HMX1	31	8	39	89.968
#156	CSDA	31	27	58	409.318
#157	SMAD5	31	20	51	725.936
#158	REST	31	14	45	675.607
#159	ZNF83	31	22	53	2095.58
#160	FOSL2	30	24	54	857.101
#161	ETV5	30	29	59	1108.89
#162	IRF4	30	4	34	65.259
#163	HAND2	30	17	47	793.834
#164	NR6A1	30	10	40	193.575
#165	JUNB	29	13	42	113.131
#166	FOXK1	29	40	69	1657.498
#167	TBX3	29	27	56	1437.422
#168	TSC22D4	29	26	55	826.17
#169	MAF	29	16	45	501.943
#170	RFXANK	29	24	53	1406.295
#171	SOX4	29	38	67	2174.935
#172	NR4A2	29	9	38	661.2
#173	CREBZF	29	14	43	510.655
#174	UHRF1	29	26	55	1326.555
#175	ADNP2	29	23	52	643.058
#176	CREB3L2	28	39	67	1427.012
#177	AEBP1	28	18	46	950.148
#178	CREB3L1	28	38	66	3777.838
#179	STAT6	28	32	60	596.448
#180	MYNN	28	16	44	482.796
#181	CREB1	28	20	48	1406.276
#182	BCL11B	28	5	33	62.453
#183	EOMES	28	5	33	378.734
#184	PRDM1	28	10	38	334.138
#185	ESRRB	27	15	42	663.433
#186	PAX7	27	12	39	54.747
#187	GABPA	27	23	50	1274.234
#188	PAX3	27	17	44	13008.547
#189	HEY1	27	34	61	2513.048
#190	ZNF397	27	22	49	503.755
#191	HMGB2	27	21	48	273.224
#192	HSF2	27	25	52	829.47
#193	HOXD10	27	19	46	635.847
#194	ZNF91	27	30	57	1006.981
#195	MLLT10	27	15	42	770.903
#196	PA2G4	27	25	52	783.519
#197	PGR	27	29	56	6929.118
#198	ANKRD30A	27	33	60	1815.92
#199	ATF2	27	34	61	1793.09
#200	NR3C1	26	16	42	207.243
#201	SIX1	26	23	49	1142.291
#202	RXRB	26	24	50	985.158
#203	SNAI2	26	30	56	1736.576
#204	SOX1	26	5	31	15.794
#205	GTF2H3	26	25	51	856.905
#206	STAT1	26	17	43	425.088
#207	CTNNB1	26	34	60	987.075
#208	ATF1	26	18	44	308.396
#209	CNOT7	26	33	59	675.857
#210	TFE3	26	23	49	995.125
#211	LHX8	26	17	43	901.845
#212	SMAD3	26	30	56	1602.35
#213	SREBF1	26	26	52	530.069
#214	THRB	25	28	53	7683.582
#215	KLF4	25	16	41	211.303
#216	GATA6	25	26	51	878.907
#217	FOXN4	25	22	47	477.532
#218	NR4A3	25	9	34	109.958
#219	ESRRA	25	17	42	573.488
#220	POU5F1B	25	16	41	77.011
#221	FBXW7	25	35	60	1431.735
#222	TAF4	25	12	37	474.912
#223	STAT2	24	29	53	1169.572
#224	FOXP4	24	30	54	562.306
#225	SCMH1	24	32	56	1694.04
#226	MESP2	24	23	47	15496.57
#227	BUD31	24	30	54	1762.232
#228	ZNF138	24	18	42	743.716
#229	NFATC2	24	14	38	451.515
#230	ZFP36L2	24	27	51	392.352
#231	NFATC1	24	33	57	1180.046
#232	TFEC	24	10	34	246.924
#233	NFYA	24	32	56	656.126
#234	GLI2	24	11	35	332.219
#235	KLF9	24	24	48	357.733
#236	STAT5B	24	24	48	598.778
#237	LASS6	24	25	49	343.302
#238	TP63	23	32	55	1003.078
#239	NFIL3	23	34	57	483.407
#240	GATAD1	23	18	41	363.075
#241	MEIS3P1	23	28	51	638.487
#242	ZNF213	23	18	41	628.418
#243	CTCF	22	30	52	1031.039
#244	TSC22D3	22	29	51	1422.947
#245	TFAP2A	22	34	56	458.297
#246	IRF2	22	30	52	2072.468
#247	TCF12	22	28	50	435.821
#248	CUX1	22	36	58	2212.887
#249	TGIF2	22	31	53	697.835
#250	SLC26A3	22	26	48	1328.285
#251	C1orf85	22	30	52	983.216
#252	STAT5A	22	32	54	990.078
#253	ZNF117	22	28	50	1910.154
#254	RFX5	21	40	61	1037.713
#255	IRX1	21	23	44	389.783
#256	PRRX1	21	13	34	553.517
#257	MMP14	21	16	37	424.106
#258	HES6	21	25	46	841.304
#259	SCAND1	21	28	49	1245.013
#260	ZFP90	21	47	68	1756.375
#261	CREBL2	21	31	52	1520.026
#262	AHCTF1	21	34	55	544.945
#263	LEF1	21	29	50	3392.39
#264	RB1	21	32	53	474.103
#265	NFIX	21	26	47	500.253
#266	GATAD2B	20	27	47	474.699
#267	TCF7	20	28	48	500.821
#268	CNOT8	20	36	56	1188.606
#269	ZFP36L1	20	33	53	1074.121
#270	CNBP	20	45	65	2199.65
#271	EPAS1	20	37	57	1318.947
#272	IRX5	20	28	48	1132.727
#273	TRIM22	20	15	35	308.243
#274	TRIM29	20	24	44	560.858
#275	SMAD6	20	15	35	201.086
#276	IRF1	20	13	33	339.201
#277	ZNF18	20	32	52	486.878
#278	SRF	20	25	45	1561.937
#279	MESP1	20	25	45	6795.208
#280	PHF5A	20	34	54	388.106
#281	FOXN3	19	12	31	241.798
#282	FOXK2	19	33	52	1656.492
#283	HOXC4	19	22	41	214.063
#284	RBPJ	19	31	50	1153.4
#285	DRAP1	19	34	53	749.027
#286	EGR4	19	17	36	72.899
#287	MAFG	19	28	47	534.142
#288	MAX	19	36	55	684.159
#289	GLIS2	19	21	40	334.183
#290	FOXJ3	19	29	48	469.929
#291	LCOR	19	28	47	332.096
#292	HOXB3	19	16	35	1033.025
#293	HOXB9	18	21	39	933.144
#294	SOX13	18	29	47	571.399
#295	FUBP1	18	22	40	414.334
#296	ZHX1	18	38	56	1251.756
#297	ZNF444	18	29	47	601.857
#298	PBX2	18	42	60	1051.824
#299	MGA	18	27	45	388.896
#300	BHLHE41	18	36	54	555.167
#301	TULP4	18	32	50	727.958
#302	MTA1	18	22	40	200.724
#303	NFKB1	18	31	49	2022.899
#304	HMG20B	18	38	56	1075.693
#305	ZSCAN18	18	29	47	236.616
#306	KDM5A	18	26	44	875.02
#307	HIRA	18	37	55	647.809
#308	SIX4	18	31	49	821.973
#309	ARX	18	27	45	1691.695
#310	IRF9	18	24	42	1071.082
#311	HOXA9	18	27	45	4222.264
#312	TCF7L2	18	37	55	757.107
#313	LASS2	18	36	54	1827.69
#314	REL	18	39	57	1038.082
#315	NFYC	18	42	60	1619.425
#316	GATA2	18	35	53	3953.566
#317	UBN1	17	30	47	688.645
#318	ZNF323	17	26	43	473.053
#319	FOXC2	17	23	40	349.956
#320	SNAPC5	17	18	35	331.184
#321	TAF1B	17	32	49	374.642
#322	DLX1	17	25	42	4442.901
#323	TRPS1	17	29	46	318.138
#324	NCOR1	17	33	50	620.908
#325	ASCL1	16	38	54	1375.502
#326	CTBP1	16	18	34	442.31
#327	SUPT4H1	16	31	47	3648.672
#328	ZNF263	16	30	46	833.101
#329	ZNF232	16	38	54	423.45
#330	CSRNP2	16	28	44	935.327
#331	MAFF	16	21	37	444.513
#332	CITED1	16	24	40	1432.74
#333	MKX	16	26	42	1394.708
#334	HOXA5	16	28	44	617.592
#335	SLC30A9	16	31	47	544.88
#336	EGR1	16	20	36	323.598
#337	EGR2	16	33	49	3602.718
#338	HSF1	16	43	59	1600.22
#339	DLX2	15	27	42	375.575
#340	MEIS1	15	41	56	642.953
#341	STRN3	15	30	45	233.396
#342	NR2F6	15	35	50	2392.02
#343	ZNF131	15	34	49	322.5
#344	IRX4	15	41	56	1148.784
#345	ZNF92	15	27	42	624.651
#346	PPARA	15	21	36	765.748
#347	RORC	15	34	49	560.8
#348	ZNF135	15	33	48	940.147
#349	BACH1	15	32	47	338.277
#350	ZSCAN29	15	37	52	425.913
#351	SOLH	15	26	41	297.392
#352	ZKSCAN1	15	29	44	544.073
#353	TFCP2L1	15	36	51	1346.714
#354	STAT4	15	17	32	159.159
#355	TADA3	15	43	58	1905.8
#356	FOXO3	15	30	45	1373.623
#357	TFAP2B	15	29	44	753.698
#358	RELA	14	43	57	682.856
#359	HOXB2	14	36	50	762.821
#360	CEBPD	14	45	59	1722.797
#361	AATF	14	31	45	679.384
#362	TAL1	14	32	46	683.279
#363	IRF3	14	32	46	1125.303
#364	FOXJ1	14	24	38	1350.511
#365	VDR	14	41	55	1127.573
#366	SIX5	14	38	52	477.392
#367	BTAF1	14	26	40	427.214
#368	FOXJ2	14	35	49	1074.297
#369	ETS2	14	26	40	399.923
#370	KLF12	13	10	23	260.05
#371	PCGF2	13	27	40	1467.357
#372	TAF6	13	29	42	808.012
#373	MTA3	13	36	49	833.615
#374	TCF25	13	43	56	1426.548
#375	ZFPM1	13	48	61	1091.13
#376	ZXDC	13	30	43	665.273
#377	MXD1	13	36	49	1104.543
#378	HOXB7	13	32	45	1224.502
#379	NR2C2	13	35	48	654.391
#380	HMGB1	13	39	52	267.218
#381	HOXB4	13	21	34	625.698
#382	NFAT5	13	25	38	372.305
#383	SOX21	12	19	31	104.385
#384	ELF1	12	39	51	937.251
#385	ASCL2	12	28	40	431.133
#386	ZNF33A	12	43	55	683.351
#387	MEF2A	12	36	48	482.401
#388	CREB3	12	36	48	851.758
#389	HOXB6	12	14	26	424.816
#390	PFDN1	12	30	42	282.71
#391	ZNF148	12	31	43	529.733
#392	CBFB	11	37	48	462.958
#393	CLOCK	11	45	56	1143.661
#394	TGIF1	11	46	57	478.636
#395	ATF6	11	42	53	1068.406
#396	RARA	11	25	36	434.794
#397	GRHL2	11	42	53	970.804
#398	DDIT3	11	31	42	550.4
#399	HEY2	11	40	51	1681.711
#400	ESRRG	11	42	53	675.088
#401	GCFC1	11	37	48	692.916
#402	SP3	11	22	33	688.227
#403	ZNF217	11	40	51	720.097
#404	CREM	11	29	40	475.12
#405	TSHZ2	11	47	58	1029.865
#406	ETV3	11	31	42	485.645
#407	BCL3	11	47	58	805.732
#408	HOXC11	11	38	49	295.42
#409	TRIM25	11	43	54	1589.637
#410	PPARD	11	21	32	112.245
#411	HNRNPAB	11	50	61	2488.674
#412	LHX6	11	29	40	488.075
#413	CEBPA	11	33	44	657.954
#414	MTF1	10	30	40	392.856
#415	USF2	10	40	50	930.457
#416	MSX2	10	37	47	319.174
#417	TEAD2	10	35	45	557.432
#418	YEATS4	10	45	55	1757.728
#419	KLF10	10	26	36	147.962
#420	BCL6	10	43	53	804.456
#421	HOXB5	10	22	32	549.82
#422	FOXO6	10	17	27	139.778
#423	MLX	10	50	60	517.446
#424	ELF4	10	34	44	307.218
#425	HNRNPK	9	47	56	619.215
#426	YY1	9	37	46	1079.62
#427	SIX2	9	33	42	354.161
#428	NOLC1	9	37	46	641.443
#429	ADNP	9	43	52	1518.996
#430	ZNF274	9	36	45	1601.648
#431	ATF4	9	34	43	512.771
#432	IRX3	9	36	45	625.415
#433	ZHX2	9	40	49	324.891
#434	TFAP2C	9	39	48	316.166
#435	ZNF238	9	35	44	418.343
#436	OVOL1	9	34	43	569.903
#437	TFDP2	8	42	50	466.961
#438	MYCL1	8	40	48	481.388
#439	EDF1	8	34	42	246.567
#440	GTF2H2	8	37	45	764.972
#441	TEAD3	8	34	42	385.133
#442	STAT3	8	43	51	466.308
#443	HMBOX1	8	46	54	514.347
#444	TARDBP	8	43	51	381.172
#445	NR1H3	8	33	41	566.054
#446	TAF7	8	36	44	586.022
#447	ZBTB38	8	40	48	810.21
#448	MYBL2	8	37	45	322.757
#449	AHR	8	46	54	786.858
#450	TSC22D2	8	50	58	376.872
#451	ARNTL	8	44	52	1020.368
#452	JDP2	7	40	47	608.388
#453	IRX2	7	49	56	962.395
#454	SOX9	7	43	50	1317.118
#455	ZRANB2	7	27	34	225.387
#456	HDAC1	7	50	57	338.499
#457	NR1D2	7	38	45	399.859
#458	TWIST1	7	46	53	872.814
#459	NKX3-1	7	45	52	260.482
#460	KLF6	7	36	43	353.725
#461	BATF	7	45	52	1563.756
#462	HES1	7	39	46	266.418
#463	TEF	7	40	47	512.094
#464	ZNF281	6	42	48	454.816
#465	NFE2L2	6	39	45	216.817
#466	SATB1	6	42	48	262.792
#467	IRF7	6	23	29	409.442
#468	SCML2	6	42	48	198.038
#469	KLF7	6	36	42	381.546
#470	WNT5A	6	38	44	704.755
#471	HIF1A	6	34	40	395.979
#472	PURB	6	41	47	868.918
#473	MAFB	6	21	27	199
#474	SMAD1	6	54	60	518.322
#475	NPAS2	6	45	51	453.921
#476	TEAD1	6	38	44	797.117
#477	NFE2L1	5	36	41	422.359
#478	RNF4	5	42	47	165.459
#479	HOXD4	5	37	42	652.039
#480	CITED2	5	42	47	319.473
#481	ERF	5	39	44	142.53
#482	MSRB2	5	55	60	499.547
#483	HOXA10	5	19	24	88.304
#484	ARNT2	5	35	40	692.437
#485	PEG3	5	48	53	516.837
#486	SREBF2	5	43	48	571.159
#487	TAF10	4	55	59	544.681
#488	TBX1	4	41	45	2756.782
#489	TSC22D1	4	46	50	1054.849
#490	UBP1	4	48	52	429.632
#491	TCFL5	3	58	61	208.056
#492	EHF	3	49	52	105.653
#493	PITX1	3	46	49	241.249
#494	RBCK1	2	32	34	109.16
#495	ELF3	2	39	41	69.925
#496	PBX3	2	47	49	210.624
#497	RARG	2	46	48	78.383
#498	HOPX	1	44	45	65.571
#499	IRF6	0	50	50	0
#500	NR2F2	0	43	43	0