Hub Rank	Node	Children	Parents	Degree	Betweenness
#1	GTF2IRD1	49	4	53	1776.428
#2	ZEB2	42	0	42	0
#3	TGIF2	39	5	44	1551.558
#4	SNAI2	38	4	42	1641.587
#5	ESRRA	38	5	43	2339.347
#6	NR3C1	37	6	43	868.814
#7	ZFPM2	36	5	41	104.253
#8	PLAGL2	35	3	38	1040.393
#9	LZTS1	33	5	38	286.501
#10	PRRX1	33	3	36	1480.223
#11	TEAD4	32	11	43	2497.883
#12	ATF2	32	8	40	458.65
#13	SP1	32	2	34	211.586
#14	SOX4	32	5	37	814.094
#15	ASCL2	31	10	41	1592.814
#16	ZEB1	31	7	38	4533.313
#17	RB1	31	3	34	77.355
#18	ETS1	30	11	41	2617.577
#19	TBX1	30	0	30	0
#20	MITF	29	1	30	4.938
#21	AFF4	28	5	33	780.561
#22	GATAD1	28	7	35	528.173
#23	AEBP1	28	3	31	23.679
#24	GLIS2	28	6	34	1099.519
#25	FLI1	28	2	30	514.568
#26	CEBPA	27	8	35	2380.553
#27	GTF2I	27	5	32	700.677
#28	ETV4	26	14	40	3360.471
#29	MEF2C	26	7	33	568.636
#30	ELK3	26	8	34	351.765
#31	C5orf41	26	9	35	1227.005
#32	HCLS1	26	2	28	13.922
#33	ARID3A	25	9	34	1662.63
#34	CDX2	25	9	34	1426.441
#35	BACH1	25	2	27	533.95
#36	GLI3	25	8	33	1669.787
#37	CREB3L1	25	8	33	1868.626
#38	CBFA2T2	25	4	29	385.361
#39	FOXM1	25	1	26	60.284
#40	CREB1	25	3	28	5843.582
#41	ATF1	25	5	30	519.574
#42	RCOR1	24	7	31	830.413
#43	AHCTF1	24	6	30	332.775
#44	ARNTL2	24	15	39	2102.854
#45	TRPS1	24	5	29	3674.037
#46	GABPA	24	6	30	295.337
#47	ERG	24	9	33	168.934
#48	MAX	24	8	32	348.017
#49	JUN	24	13	37	3147.126
#50	EBF1	24	10	34	1788.187
#51	PEG3	24	6	30	3997.157
#52	NOLC1	24	11	35	1268.14
#53	CNOT8	23	7	30	1893.572
#54	ATOH1	23	5	28	470.911
#55	SPDEF	23	3	26	2358.97
#56	MYC	23	9	32	1071.398
#57	SATB2	23	8	31	678.154
#58	FOXO6	23	8	31	1098.955
#59	AHR	23	10	33	2889.452
#60	MEF2A	23	11	34	1139.162
#61	TWIST1	22	7	29	141.624
#62	IRF2	22	13	35	2590.236
#63	CBFA2T3	22	12	34	1630.56
#64	MEIS2	22	11	33	684.989
#65	ENO1	22	13	35	1315.9
#66	NFYB	21	11	32	612.004
#67	TRIM28	21	7	28	544.454
#68	HHEX	21	9	30	803.772
#69	FOXJ3	21	7	28	257.119
#70	SP3	21	9	30	3980.156
#71	TAF4	21	9	30	539.24
#72	POU2F2	21	2	23	55.862
#73	C1orf85	20	10	30	602.193
#74	E2F5	20	15	35	3552.912
#75	ISX	20	12	32	1537.891
#76	HSF1	20	8	28	1568.68
#77	MAFB	20	13	33	1037.446
#78	ZFP36L2	20	6	26	437.473
#79	CITED2	20	10	30	3040.314
#80	CBFB	20	6	26	119.942
#81	NKX2-3	20	6	26	1479.728
#82	HIF1A	19	10	29	587.076
#83	KLF9	19	14	33	1527.282
#84	STRN3	19	7	26	2290.603
#85	MECOM	19	15	34	1813.757
#86	ELF1	19	10	29	1512.124
#87	MEIS1	19	9	28	6647.06
#88	HMGA1	19	12	31	807.612
#89	UHRF1	19	5	24	381.736
#90	PBX3	19	9	28	2912.925
#91	E2F8	19	4	23	237.047
#92	NFE2L3	19	13	32	3697.827
#93	KLF3	18	10	28	873.14
#94	IRF6	18	8	26	909.404
#95	ZNF131	18	3	21	92.891
#96	MAFK	18	12	30	1645.444
#97	RORA	18	10	28	524.866
#98	HOXA1	18	9	27	1407.877
#99	CSRNP3	18	17	35	2766.24
#100	MEF2D	18	12	30	5245.338
#101	MGA	18	6	24	1637.864
#102	HNF1B	18	11	29	1367.264
#103	E2F7	18	4	22	485.827
#104	NFIL3	18	8	26	1297.005
#105	HOPX	18	8	26	136.753
#106	HOXA5	18	6	24	1229.109
#107	TFAP2A	18	11	29	2713.987
#108	RUNX1T1	18	11	29	748.191
#109	ZNF277	17	12	29	1541.114
#110	TAF12	17	11	28	791.668
#111	KLF4	17	12	29	1182.86
#112	SMAD2	17	10	27	966.458
#113	MBD1	17	8	25	762.228
#114	MNT	17	4	21	91.815
#115	TCF4	17	15	32	1281.681
#116	NR1I2	17	10	27	568.782
#117	TSHZ3	17	11	28	752.61
#118	NFXL1	17	11	28	1919.474
#119	ADNP	17	15	32	1684.333
#120	BUD31	17	11	28	3473.373
#121	LASS6	17	9	26	489.293
#122	ZNF281	17	13	30	1868.253
#123	EHF	17	14	31	379.075
#124	CREB3L4	17	5	22	906.775
#125	ARNTL	17	15	32	1273.579
#126	ETV1	16	14	30	798.327
#127	PURA	16	15	31	4264.701
#128	PBX1	16	15	31	1789.273
#129	PPARA	16	12	28	706.976
#130	RXRB	16	9	25	805.354
#131	ESR1	16	5	21	227.466
#132	ZRANB2	16	7	23	230.708
#133	TRIM22	16	10	26	1198.154
#134	MEOX2	16	10	26	3527.69
#135	SMAD5	16	14	30	1021.481
#136	NR1D2	16	13	29	488.556
#137	ETV5	16	3	19	174.52
#138	TWIST2	16	7	23	207.123
#139	BHLHE40	16	11	27	1722.048
#140	PPARG	16	14	30	1515.082
#141	ZNF217	16	15	31	1740.177
#142	BCL6	16	12	28	2723.429
#143	HOXD1	16	7	23	2111.532
#144	STAT2	16	12	28	1335.661
#145	HIC1	16	12	28	731.225
#146	BACH2	15	14	29	11597.656
#147	ZNF483	15	6	21	248.944
#148	CUX1	15	10	25	904.195
#149	SCML1	15	14	29	1270.384
#150	FOXA2	15	11	26	2714.998
#151	ZNF81	15	3	18	86.079
#152	GATAD2A	15	16	31	1356.167
#153	OVOL1	15	9	24	383.068
#154	ETV6	15	6	21	125.639
#155	IKZF1	15	7	22	2790.914
#156	TCF12	15	4	19	176.306
#157	TLX2	15	5	20	171.022
#158	SCAND1	15	17	32	1187.438
#159	TFAM	15	15	30	1840.725
#160	LEF1	15	8	23	547.151
#161	ZHX2	14	13	27	2916.839
#162	TULP4	14	17	31	4140.958
#163	TFCP2	14	12	26	348.947
#164	RFXAP	14	18	32	2967.094
#165	TFE3	14	8	22	562.298
#166	NR5A2	14	15	29	3574.689
#167	TEF	14	13	27	2090.534
#168	FOXD2	14	12	26	639.384
#169	TGIF1	14	6	20	480
#170	NR1H4	14	5	19	878.288
#171	MXD1	14	19	33	2829.387
#172	TCFL5	14	17	31	1341.985
#173	EPAS1	14	15	29	4068.913
#174	ZKSCAN1	14	7	21	353.502
#175	HES1	14	11	25	2773.063
#176	SMAD4	14	4	18	680.966
#177	NFX1	14	5	19	501.038
#178	FUBP1	14	4	18	1015.463
#179	RUNX1	14	9	23	671.969
#180	HMG20B	14	14	28	721.45
#181	HOXA9	14	5	19	1242.09
#182	KLF2	14	14	28	1319.727
#183	ZNF75D	14	9	23	951.943
#184	HNF4G	13	11	24	2494.805
#185	NCOR1	13	14	27	2090.869
#186	TSC22D3	13	4	17	54.213
#187	NFATC3	13	9	22	1015.699
#188	FOXF1	13	10	23	1133.698
#189	ADNP2	13	18	31	1263.246
#190	FOXN3	13	20	33	2317.614
#191	GATA6	13	18	31	1419.615
#192	C11orf9	13	10	23	1197.046
#193	GTF2H3	13	14	27	4941.726
#194	EGR3	13	6	19	1719.179
#195	DLX1	13	6	19	2598.752
#196	CREBZF	13	14	27	4724.964
#197	ZNF138	13	11	24	1948.847
#198	HEY1	13	11	24	982.222
#199	KDM5B	13	14	27	2168.932
#200	TSC22D2	13	21	34	3164.273
#201	TARDBP	13	6	19	2298.601
#202	SUPT6H	13	6	19	525.876
#203	FOXK1	13	15	28	1321.394
#204	TSHZ2	13	10	23	3298.98
#205	TCF3	12	16	28	2638.551
#206	HEYL	12	9	21	4652.505
#207	PRDM1	12	11	23	626.907
#208	TRIM25	12	17	29	1422.315
#209	GCFC1	12	16	28	2743.443
#210	HIF3A	12	9	21	2093.532
#211	TAF5	12	12	24	827.436
#212	NR4A1	12	7	19	757.635
#213	SOLH	12	15	27	864.719
#214	RCAN1	12	13	25	411.12
#215	ZNF117	12	15	27	1590.783
#216	ETV7	12	10	22	689.687
#217	ZC3H8	12	13	25	1399.404
#218	FOXQ1	12	19	31	3098.75
#219	ZNF238	12	9	21	1001.928
#220	ZNF207	12	7	19	442.529
#221	ZSCAN18	12	16	28	1144.123
#222	HOXA10	12	7	19	1662.046
#223	TFDP1	12	12	24	1509.134
#224	E2F3	12	11	23	1789.403
#225	FOXD1	12	19	31	1786.674
#226	PITX1	12	14	26	1536.156
#227	TAF13	12	15	27	7176.41
#228	PTTG1	12	6	18	879.813
#229	ZNF148	12	12	24	1791.286
#230	TFCP2L1	12	16	28	1243.194
#231	NFATC2	12	15	27	1306.18
#232	LMO4	12	15	27	605.882
#233	TFEC	12	9	21	284.442
#234	NOTCH1	12	8	20	521.609
#235	ZNF92	12	9	21	618.884
#236	GAS7	12	11	23	544.379
#237	SPEN	12	11	23	1473.173
#238	HNF4A	12	14	26	1429.606
#239	ZNF3	12	14	26	2517.48
#240	SLC26A3	12	23	35	4359.479
#241	HOXA3	12	11	23	1372.868
#242	NFATC1	12	14	26	779.209
#243	NFYA	11	18	29	1627.353
#244	NR4A2	11	12	23	757.62
#245	TRIM29	11	15	26	1512.405
#246	CDKN2A	11	16	27	3154.356
#247	NR2F2	11	18	29	1073.792
#248	CREM	11	12	23	288.362
#249	BATF2	11	10	21	572.067
#250	JUND	11	12	23	857.149
#251	CNOT7	11	17	28	902.298
#252	GBX2	11	5	16	82.973
#253	CEBPB	11	14	25	1057.677
#254	NFIC	11	20	31	1965.628
#255	ZNF639	11	11	22	3285.562
#256	BATF	11	14	25	1012.659
#257	SIX4	11	15	26	1453.735
#258	XBP1	11	8	19	1395.672
#259	TEAD1	11	9	20	413.463
#260	ZSCAN16	11	14	25	2031.101
#261	ATF5	11	9	20	288.851
#262	MLXIPL	11	18	29	1219.911
#263	KDM5A	11	9	20	801.894
#264	MYNN	11	10	21	679.284
#265	HDAC2	11	11	22	883.474
#266	HOXB5	11	9	20	757.599
#267	FOXA3	10	13	23	479.38
#268	SCML2	10	12	22	625.217
#269	RUNX3	10	11	21	3657.877
#270	SALL1	10	10	20	1278.125
#271	FOXO1	10	19	29	3009.04
#272	TCF7	10	17	27	2631.084
#273	ISL1	10	18	28	2290.612
#274	GLI2	10	11	21	366.855
#275	MYBL2	10	12	22	1471.536
#276	HOXB2	10	15	25	1616.955
#277	NFKB2	10	7	17	587.043
#278	SIN3A	10	13	23	937.003
#279	HSF2	10	9	19	183.838
#280	SOX9	10	21	31	5838.989
#281	MTA1	10	13	23	510.629
#282	STAT4	10	15	25	3546.528
#283	ZNF367	10	10	20	464.109
#284	ZNF45	10	19	29	1697.257
#285	MEIS3P1	10	17	27	2128.281
#286	NR2C1	10	16	26	1289.156
#287	EN2	10	12	22	1439.927
#288	RUNX2	10	10	20	555.774
#289	FOS	10	10	20	970.594
#290	RBCK1	10	17	27	1132.025
#291	HMGB2	10	11	21	1144.273
#292	SMAD9	9	16	25	1989.379
#293	HR	9	13	22	420.012
#294	THRA	9	8	17	1436.424
#295	MLLT10	9	10	19	1155.734
#296	NKX2-1	9	8	17	881.509
#297	FOSB	9	6	15	637.529
#298	MNX1	9	10	19	892.387
#299	ETS2	9	14	23	982.022
#300	MAF	9	8	17	265.629
#301	NEUROD1	9	9	18	1659.84
#302	ATF3	9	8	17	1546.85
#303	FOXP1	9	11	20	1180.195
#304	HOXD8	9	15	24	1725.208
#305	PURB	9	14	23	583.844
#306	HOXD4	9	14	23	1170.561
#307	CSRNP1	9	12	21	887.746
#308	PROX1	9	16	25	1009.278
#309	ZBTB38	9	18	27	2553.91
#310	SLC2A4RG	9	11	20	469.996
#311	JUNB	9	7	16	689.651
#312	PCGF2	8	15	23	1178.082
#313	HOXA7	8	7	15	608.565
#314	HES6	8	14	22	1338.322
#315	CLOCK	8	17	25	2215.63
#316	PBX2	8	11	19	354.047
#317	TEAD2	8	19	27	1446.634
#318	FOXP2	8	20	28	1955.955
#319	ELF3	8	15	23	1366.419
#320	SPI1	8	16	24	344.725
#321	NFAT5	8	13	21	1031.079
#322	FOXC1	8	18	26	967.193
#323	ZNF91	8	22	30	2742.743
#324	YEATS4	8	18	26	796.474
#325	ZNF165	8	20	28	1241.317
#326	HOXD10	8	13	21	1535.456
#327	ZNF41	8	10	18	1048.799
#328	ZHX1	8	12	20	712.275
#329	SOX1	8	15	23	2818.661
#330	BHLHE41	8	22	30	791.788
#331	HOXB3	8	10	18	564.193
#332	RERE	8	5	13	19.197
#333	BLZF1	8	19	27	1797.671
#334	ARX	8	17	25	2534.567
#335	NR2F1	8	18	26	780.217
#336	HOXB8	8	6	14	583.498
#337	MYCL1	8	12	20	905.053
#338	SP4	7	18	25	1052.604
#339	GRHL3	7	17	24	1801.733
#340	PBX4	7	13	20	1460.8
#341	TCF7L2	7	12	19	289.691
#342	FOSL2	7	13	20	795.866
#343	ST18	7	9	16	1826.421
#344	ARNT	7	13	20	696.115
#345	SREBF1	7	13	20	613.482
#346	ZNF192	7	9	16	236.035
#347	HIRA	7	20	27	1717.35
#348	ARNT2	7	19	26	982.4
#349	HMGB1	7	16	23	719.939
#350	HOXD11	7	6	13	906.042
#351	MAFF	7	18	25	989.058
#352	EGR1	7	14	21	757.899
#353	BTG2	7	12	19	860.736
#354	SIX1	7	15	22	455.481
#355	ZFP90	7	18	25	2469.949
#356	MSX1	7	17	24	2327.038
#357	ZNF83	7	20	27	1070.45
#358	HOXB9	7	17	24	1934.503
#359	ZXDA	7	15	22	753.896
#360	ELF4	7	14	21	487.72
#361	NR3C2	7	16	23	490.256
#362	IRF7	7	13	20	476.377
#363	TRERF1	7	23	30	1238.765
#364	GLIS3	7	12	19	200.264
#365	RORC	7	15	22	1050.291
#366	TP63	7	9	16	1058.999
#367	MMP14	7	14	21	297.727
#368	FOSL1	7	24	31	1171.176
#369	SOX7	7	12	19	501.188
#370	POU4F3	7	8	15	73.953
#371	TCF21	7	8	15	110.03
#372	PLSCR1	7	13	20	1373.798
#373	HNRNPAB	7	16	23	636.668
#374	NR2F6	7	12	19	2735.031
#375	ZNF268	7	14	21	1523.788
#376	MSRB2	6	16	22	1485.534
#377	CEBPD	6	14	20	698.936
#378	NPAS2	6	22	28	2081.364
#379	BCL11B	6	23	29	1222.499
#380	HOXA11	6	12	18	584.892
#381	CREBL2	6	20	26	381.788
#382	GRHL2	6	9	15	203.588
#383	DLX6	6	14	20	1278.114
#384	NFE2L2	6	15	21	649.935
#385	TAF4B	6	18	24	891.172
#386	SATB1	6	23	29	1656.452
#387	KLF7	6	18	24	549.714
#388	CREB3L2	6	17	23	705.121
#389	NFIB	6	13	19	997.324
#390	TCEAL1	6	17	23	743.476
#391	SMAD1	6	18	24	1615.93
#392	KLF5	6	20	26	1590.049
#393	SLC30A9	6	13	19	384.033
#394	MEOX1	6	13	19	758.385
#395	EGR2	6	11	17	1311.616
#396	PHTF1	6	14	20	603.405
#397	ONECUT2	6	21	27	1730.385
#398	PITX2	6	14	20	377.344
#399	TBX3	6	14	20	709.917
#400	ZFHX3	6	16	22	999.059
#401	STAT1	6	7	13	701.937
#402	HMGA2	6	24	30	2246.013
#403	MESP1	6	15	21	996.839
#404	BRD8	6	13	19	754.367
#405	CSDA	6	17	23	459.773
#406	CITED1	6	14	20	881.401
#407	SIM2	6	16	22	1221.238
#408	FOXO3	6	20	26	644.525
#409	SOX12	5	7	12	1117.469
#410	ATF7	5	19	24	719.152
#411	IRF1	5	13	18	443.034
#412	ZNF24	5	17	22	2473.347
#413	PA2G4	5	17	22	843.272
#414	C2orf3	5	16	21	576.255
#415	IRX5	5	15	20	1184.018
#416	CTNNB1	5	17	22	722.689
#417	IRF9	5	11	16	391.181
#418	MSX2	5	16	21	1244.405
#419	TFDP2	5	17	22	1009.922
#420	ZNF140	5	15	20	703.542
#421	SOX2	5	15	20	904.569
#422	IRX3	5	22	27	2716.63
#423	WNT5A	5	18	23	1493.39
#424	ZNF37A	5	13	18	393.772
#425	JDP2	5	10	15	556.044
#426	SIX3	5	6	11	452.303
#427	ARID4A	5	18	23	1276.884
#428	ZNF323	5	20	25	1924.707
#429	FOXF2	5	10	15	1341.386
#430	SMAD6	5	19	24	995.36
#431	TP53	5	23	28	995.392
#432	SOX13	5	15	20	2587.904
#433	ZNF33B	5	17	22	1317.516
#434	ZNF274	5	18	23	431.814
#435	POU2F3	4	9	13	765.996
#436	KLF12	4	20	24	744.305
#437	DMRT2	4	22	26	1405.625
#438	RARA	4	23	27	1679.384
#439	FBXW7	4	15	19	1157.801
#440	CTBP1	4	15	19	1524.011
#441	ZNF167	4	12	16	905.616
#442	DDIT3	4	20	24	713.83
#443	KLF10	4	17	21	659.334
#444	HOXA2	4	16	20	394.889
#445	HOXB7	4	13	17	815.86
#446	HOXA13	4	12	16	288.015
#447	SPIB	4	9	13	178.159
#448	ZNF93	4	16	20	928.229
#449	SOX11	4	15	19	361.288
#450	NR1H2	4	13	17	503.898
#451	LCOR	4	18	22	1027.555
#452	SOX6	4	16	20	410.608
#453	ZNF256	4	18	22	1149.88
#454	IRF8	4	17	21	676.831
#455	VDR	4	20	24	610.23
#456	KLF6	4	20	24	394.133
#457	UBP1	4	18	22	161.465
#458	ZNF397	4	14	18	214.48
#459	ZNF134	4	15	19	680.767
#460	CREB5	4	16	20	567.088
#461	FOXC2	3	12	15	1577.572
#462	ELF5	3	21	24	286.962
#463	NFIA	3	19	22	412.644
#464	SOX8	3	9	12	293.496
#465	PAX6	3	12	15	412.351
#466	HOXB6	3	15	18	279.488
#467	FOXG1	3	10	13	130.631
#468	PLAG1	3	24	27	1297.502
#469	ZNF643	3	21	24	839.356
#470	SUPT4H1	3	18	21	1417.231
#471	SREBF2	3	16	19	135.691
#472	FOXA1	3	20	23	513.19
#473	NR1H3	3	23	26	337.161
#474	REL	3	20	23	346.177
#475	NR4A3	3	9	12	105.737
#476	HMBOX1	3	17	20	662.286
#477	ZFP36L1	3	17	20	594.955
#478	IRF5	3	11	14	577.845
#479	ZNF232	2	20	22	327.922
#480	KLF11	2	16	18	320.381
#481	TSHZ1	2	16	18	555.155
#482	DMRT1	2	8	10	157.1
#483	ZNF85	2	15	17	257.482
#484	CBL	2	16	18	276.575
#485	ATF6	2	21	23	876.203
#486	MYCN	2	16	18	525.824
#487	KCNH8	2	16	18	581.733
#488	IRX2	1	21	22	113.767
#489	ELK4	1	19	20	85.659
#490	HOXD13	1	16	17	641.158
#491	ZIC2	1	22	23	1784.788
#492	THRB	1	22	23	237.795
#493	GTF2H2	1	11	12	32.727
#494	MKX	1	17	18	144.558
#495	ESRRG	1	14	15	264.702
#496	SCAND3	1	13	14	61.397
#497	TFAP2C	0	20	20	0
#498	TSC22D1	0	19	19	0
#499	HOXB13	0	22	22	0
#500	WT1	0	18	18	0