Hub Rank	Node	Children	Parents	Degree	Betweenness
#1	PRRX1	38	4	42	744.978
#2	TCF4	38	3	41	528.961
#3	PROX1	34	5	39	558.695
#4	EBF1	34	5	39	2584.482
#5	KLF2	32	5	37	161.094
#6	HCLS1	31	0	31	0
#7	NR3C1	31	4	35	911.633
#8	ZEB2	29	6	35	4273.884
#9	MAFB	29	5	34	303.049
#10	MYC	29	9	38	1402.822
#11	AEBP1	28	5	33	491.107
#12	KLF4	28	4	32	1418.873
#13	RUNX3	28	1	29	11.417
#14	ETV4	27	7	34	390.374
#15	MMP14	27	6	33	301.491
#16	NEUROD1	27	5	32	519.164
#17	NKX2-3	27	10	37	2971.382
#18	NR3C2	27	1	28	29.63
#19	SOX18	26	4	30	141.237
#20	SLC26A3	26	8	34	3555.121
#21	SOX4	26	4	30	352.577
#22	TWIST1	25	6	31	349.411
#23	FOXQ1	24	11	35	1190
#24	MSX1	24	5	29	241.644
#25	BHLHE40	24	8	32	1937.75
#26	MEF2C	24	6	30	518.305
#27	ISX	23	4	27	357.409
#28	SOX9	23	5	28	197.468
#29	NFE2L3	22	8	30	1560.406
#30	ISL1	22	11	33	2894.044
#31	SPI1	22	12	34	2014.946
#32	MAFK	21	9	30	2314.626
#33	SUPT6H	21	6	27	696.242
#34	NR5A2	21	7	28	1137.863
#35	MESP2	20	8	28	1089.884
#36	ETV1	20	7	27	3536.324
#37	FOXO3	20	7	27	743.655
#38	TFEC	20	8	28	938.574
#39	ZFPM2	20	10	30	1567.814
#40	TEAD4	20	9	29	679.753
#41	PRDM1	20	8	28	2033.25
#42	ARNTL2	20	9	29	2799.809
#43	SPEN	19	7	26	1417.032
#44	EGR3	19	10	29	1342.711
#45	NFKB2	19	13	32	3047.25
#46	VAV1	19	5	24	504.003
#47	AHCTF1	19	6	25	748.398
#48	HES6	19	6	25	654.898
#49	MEOX1	18	11	29	1679.788
#50	FOXM1	18	7	25	2146.5
#51	FOXP2	18	19	37	8754.952
#52	THRB	18	8	26	534.475
#53	NR2E3	18	8	26	1134.297
#54	TCF21	18	9	27	253.468
#55	SPDEF	18	6	24	613.631
#56	HES5	18	9	27	422.672
#57	HNF4G	18	8	26	2268.506
#58	ZNF496	18	13	31	3207.854
#59	PAX6	18	6	24	1312.825
#60	NFE2	18	10	28	1076.137
#61	UHRF1	17	6	23	440.199
#62	CREM	17	6	23	619.798
#63	SPIB	17	12	29	823.313
#64	HNF1B	17	8	25	1749.945
#65	IRF6	17	5	22	406.197
#66	TCF3	17	13	30	1340.569
#67	MBD1	17	10	27	3844.455
#68	KLF5	17	10	27	2159.019
#69	ONECUT1	16	13	29	2116.176
#70	NR1I2	16	11	27	1423.635
#71	SATB2	16	13	29	1046.108
#72	ZEB1	16	8	24	1135.688
#73	LASS6	16	9	25	1237.092
#74	ARNT	16	9	25	1048.351
#75	MYBL2	16	8	24	2457.694
#76	ETS1	16	10	26	748.539
#77	RORC	16	7	23	540.7
#78	BATF	15	6	21	435.017
#79	GAS7	15	14	29	2151.604
#80	SOX2	15	9	24	2122.267
#81	WT1	15	11	26	1563.119
#82	HOXA13	15	5	20	2343.283
#83	OVOL1	15	6	21	668.031
#84	MAFF	15	7	22	573.465
#85	ZNF92	15	10	25	2491.116
#86	SIM2	15	9	24	1321.178
#87	ZNF396	15	6	21	492.564
#88	ZNF132	15	15	30	3353.858
#89	EGR2	15	6	21	249.058
#90	ZNF174	14	6	20	888.024
#91	DLX6	14	13	27	1404.569
#92	TLX1	14	7	21	1663.82
#93	MESP1	14	15	29	1227.549
#94	EGR1	14	6	20	341.261
#95	LEF1	14	10	24	1401.792
#96	TFE3	14	14	28	1038.039
#97	TAF4	14	13	27	2327.847
#98	CREB5	14	9	23	770.316
#99	BACH2	14	10	24	897.732
#100	PKNOX2	14	11	25	609.536
#101	YY1	14	9	23	995.89
#102	LHX6	14	10	24	424.076
#103	NR4A3	14	10	24	1258.386
#104	FOSL1	14	10	24	566.332
#105	MEF2D	14	8	22	2642.724
#106	JUND	14	5	19	902.059
#107	POU3F3	14	11	25	2042.31
#108	SOX10	14	12	26	1427.497
#109	CLOCK	14	10	24	1097.918
#110	POU4F1	13	7	20	1377.361
#111	MYOG	13	8	21	1500.831
#112	PITX1	13	8	21	1892.052
#113	PLAG1	13	9	22	1405.897
#114	SIX5	13	9	22	2799.766
#115	MAF	13	8	21	1706.207
#116	FOXA2	13	12	25	776.849
#117	FOXP3	13	8	21	922.876
#118	ENO1	13	10	23	1898.338
#119	RB1	13	6	19	948.925
#120	KDM5A	13	12	25	1161.956
#121	MEIS3	13	9	22	1200.547
#122	MTA2	13	12	25	2230.338
#123	STAT1	13	12	25	900.554
#124	NR2F6	13	18	31	2211.436
#125	POU2F2	13	10	23	1638.439
#126	NOTCH1	13	11	24	1745.441
#127	HOXA9	13	6	19	991.825
#128	NFIX	13	15	28	1785.084
#129	ZNF157	13	10	23	3429.702
#130	TAF1B	13	9	22	2082.871
#131	SP3	13	10	23	3393.966
#132	ARNTL	13	9	22	2538.937
#133	HOXA10	13	6	19	854.538
#134	CDX2	12	11	23	596.644
#135	CTNNB1	12	10	22	2673.979
#136	ZHX2	12	6	18	1075.621
#137	DLX4	12	5	17	1160.696
#138	TWIST2	12	8	20	383.118
#139	C11orf9	12	10	22	778.132
#140	NFATC2	12	11	23	1654.65
#141	ZSCAN20	12	10	22	1666.199
#142	KLF12	12	9	21	1394.382
#143	HCFC1	12	9	21	1189.255
#144	FOXD2	12	12	24	1762.858
#145	USF1	12	6	18	3457.468
#146	IKZF3	12	13	25	1714.392
#147	ARX	12	11	23	1264.297
#148	PBX3	12	12	24	2357.24
#149	ATOH1	12	13	25	1042.842
#150	NEUROG1	12	11	23	1961.079
#151	HEY2	12	13	25	3098.631
#152	WNT5A	12	9	21	1896.638
#153	MSX2	12	15	27	1088.938
#154	HOXC12	12	8	20	975.282
#155	PPARG	12	6	18	407.098
#156	ASCL2	12	16	28	1478.253
#157	SOX30	12	9	21	1407.171
#158	TFAP2C	11	13	24	744.263
#159	HOXA5	11	8	19	569.601
#160	TADA2A	11	10	21	1438.768
#161	PRDM2	11	16	27	1960.723
#162	ESR2	11	9	20	1292.04
#163	TAF13	11	10	21	1604.936
#164	T	11	12	23	2499.037
#165	NR2C1	11	8	19	1385.957
#166	IRX3	11	12	23	1578.709
#167	POU6F1	11	14	25	1389.703
#168	VENTX	11	8	19	839.726
#169	EHF	11	5	16	585.105
#170	RFXAP	11	11	22	862.407
#171	ZNF71	11	12	23	560.809
#172	TCF7	11	10	21	1045.415
#173	SMAD9	11	12	23	1860.465
#174	TFAP2A	11	6	17	271.052
#175	ZNF83	11	8	19	2156.996
#176	KLF15	11	11	22	2352.624
#177	NANOGNB	11	12	23	1816.546
#178	RCAN1	11	8	19	523.535
#179	ZHX3	11	15	26	1102.625
#180	MXD1	11	13	24	1744.986
#181	ZSCAN1	11	9	20	1346.048
#182	MZF1	11	10	21	1678.554
#183	NFYC	11	11	22	1478.348
#184	LHX2	11	16	27	1800.319
#185	MYT1L	11	9	20	1476.947
#186	PURB	11	13	24	2166.876
#187	ZSCAN18	10	6	16	630.723
#188	ZNF75D	10	11	21	1699.464
#189	SIX2	10	8	18	1043.32
#190	HOXB13	10	15	25	1067.834
#191	PAX7	10	8	18	2251.369
#192	KLF9	10	9	19	2068.529
#193	PHF1	10	10	20	1780.442
#194	FOS	10	7	17	375.3
#195	ZNF449	10	7	17	1186.307
#196	HR	10	16	26	632.633
#197	LMO4	10	11	21	1624.85
#198	SOX13	10	9	19	985.801
#199	HMGB2	10	7	17	847.188
#200	FOXC1	10	13	23	842.546
#201	HEY1	10	12	22	1240.681
#202	ZXDC	10	10	20	1471.077
#203	ATF2	10	12	22	2167.927
#204	SOX1	10	9	19	537.84
#205	RERE	10	10	20	1271.813
#206	POU1F1	10	11	21	1544.927
#207	BNC1	10	12	22	2822.165
#208	ETV6	10	11	21	972.6
#209	NFYA	10	7	17	863.532
#210	NPAS1	10	11	21	1627.94
#211	HOXD3	10	9	19	1623.385
#212	RARA	10	9	19	1062.901
#213	BLZF1	10	10	20	1088.367
#214	LHX1	10	9	19	1191.961
#215	FOXS1	9	11	20	680.294
#216	NR1H4	9	12	21	948.263
#217	HIC1	9	11	20	759.623
#218	GATA3	9	8	17	375.654
#219	FOXD1	9	9	18	521.536
#220	RORB	9	11	20	1844.262
#221	ESX1	9	13	22	1408.612
#222	HOXD4	9	9	18	1344.761
#223	SOX5	9	11	20	963.953
#224	TEAD2	9	12	21	2353.192
#225	HOXD10	9	9	18	994.535
#226	TBX2	9	18	27	2165.721
#227	ESR1	9	8	17	1115.791
#228	PPARD	9	12	21	1266.616
#229	ZNF193	9	9	18	1469.727
#230	IRF4	9	11	20	1907.687
#231	HOXB8	9	13	22	1688.419
#232	HOXD11	9	10	19	1621.361
#233	NKX6-2	9	13	22	1649.813
#234	FOXO1	9	6	15	522.114
#235	CITED1	9	12	21	1183.505
#236	MLLT10	9	10	19	1114.041
#237	ZNF202	9	10	19	468.439
#238	ZNF219	9	13	22	2499.44
#239	RXRG	9	10	19	897.948
#240	CTBP1	9	10	19	921.437
#241	ZFHX3	9	7	16	668.978
#242	DMRT1	9	17	26	1604.531
#243	FOXN4	9	9	18	794.782
#244	EMX1	9	10	19	1620.517
#245	SCAND3	9	7	16	1013.28
#246	TRPS1	9	14	23	1972.327
#247	FOXH1	9	10	19	1012.262
#248	CSRNP3	8	12	20	1261.907
#249	HOXA7	8	4	12	177.34
#250	NFIC	8	11	19	1165.032
#251	TFCP2L1	8	7	15	326.763
#252	HOXD9	8	13	21	1133.546
#253	MYCL1	8	6	14	1176.403
#254	HNF4A	8	12	20	934.275
#255	SMAD2	8	11	19	780.381
#256	SOX21	8	11	19	1431.28
#257	LHX9	8	13	21	2827.959
#258	OTX2	8	10	18	749.892
#259	ESRRB	8	12	20	1794.856
#260	ALX3	8	12	20	1772.08
#261	POU5F2	8	10	18	2502.111
#262	VTN	8	10	18	1141.239
#263	SOX11	8	9	17	1360.908
#264	SCAND2	8	12	20	1642.699
#265	MEIS1	8	15	23	506.944
#266	CDKN2A	8	12	20	653.541
#267	ZSCAN2	8	11	19	1452.956
#268	HOXC8	8	5	13	627.33
#269	C12orf28	8	10	18	726.681
#270	TEF	8	13	21	1165.359
#271	BHLHE41	8	9	17	852.012
#272	TFAP2D	8	6	14	684.796
#273	ZNF80	8	9	17	754.643
#274	ESRRG	8	10	18	1112.331
#275	HOXD13	8	7	15	671.754
#276	HESX1	8	13	21	1192.728
#277	SIX3	8	13	21	2047.212
#278	SIX1	8	9	17	1241.24
#279	ZNF207	8	15	23	1888.87
#280	RARB	8	11	19	1480.543
#281	BCL6	8	8	16	950.685
#282	HIF3A	8	9	17	714.924
#283	POU2F3	8	17	25	1761.702
#284	TADA3	8	13	21	1711.924
#285	BUD31	8	11	19	1035.71
#286	ATF6B	8	15	23	1595.238
#287	FEV	8	8	16	709.073
#288	MYCN	8	16	24	1646.002
#289	ZBTB38	8	7	15	545.799
#290	HIRA	8	14	22	2319.072
#291	ELF4	8	8	16	4018.097
#292	FOXL2	8	10	18	736.695
#293	TCF20	8	12	20	1703.449
#294	PGBD1	8	11	19	1632.403
#295	MIXL1	8	8	16	977.289
#296	RUNX2	8	13	21	2063.061
#297	DMBX1	8	12	20	1070.679
#298	KLF16	8	15	23	1204.553
#299	HOXA11	8	14	22	2765.436
#300	TP73	8	11	19	1676.539
#301	IRX1	8	9	17	1075.987
#302	FOXK1	7	8	15	616.095
#303	MKX	7	12	19	1109.509
#304	ST18	7	17	24	2193.683
#305	ZNF131	7	11	18	1066.366
#306	E2F2	7	12	19	2041.974
#307	TBX20	7	12	19	1591.227
#308	FOXP1	7	11	18	534.871
#309	POU3F1	7	10	17	934.638
#310	ZNF167	7	11	18	848.179
#311	ZNF446	7	10	17	1012.581
#312	HOXC5	7	7	14	881.348
#313	MYT1	7	12	19	1208.378
#314	PAX4	7	10	17	601.804
#315	ZIC5	7	18	25	2257.832
#316	SNAPC5	7	13	20	837.838
#317	PBX4	7	10	17	360.392
#318	MYNN	7	11	18	1810.049
#319	ETV5	7	13	20	1538.22
#320	HOXA2	7	10	17	697.487
#321	TRIM29	7	11	18	252.885
#322	ZSCAN23	7	10	17	2099.294
#323	EN2	7	11	18	429.912
#324	MAFG	7	13	20	416.653
#325	SP140	7	13	20	1988.43
#326	CREB3L3	7	13	20	791.587
#327	PAX3	7	10	17	2375.797
#328	PHOX2B	7	9	16	828.211
#329	FOXE1	7	11	18	1302.178
#330	STAT5B	7	9	16	1238.57
#331	PLSCR1	7	14	21	1426.467
#332	CUX2	7	10	17	1516.261
#333	TSC22D1	7	9	16	614.514
#334	FOXC2	7	11	18	1433.255
#335	HOPX	7	10	17	1072.687
#336	FOXA1	7	10	17	342.173
#337	TBX1	7	13	20	1502.158
#338	TLX3	7	12	19	670.312
#339	FOSB	7	3	10	252.781
#340	STRN3	7	10	17	982.158
#341	GATA1	7	9	16	1022.49
#342	CBL	7	12	19	1257.232
#343	SMAD6	7	8	15	923.549
#344	ZIC1	7	9	16	685.446
#345	GRHL3	7	13	20	598.237
#346	NKX2-8	7	9	16	1545.019
#347	SEBOX	7	8	15	760.655
#348	ISL2	7	14	21	1232.381
#349	RORA	7	12	19	1082.298
#350	NR4A2	7	7	14	299.934
#351	FOXN3	7	9	16	811.139
#352	ETV7	6	9	15	225.299
#353	NFATC1	6	5	11	202.412
#354	TLX2	6	8	14	1080.471
#355	TBX6	6	11	17	933.248
#356	TBX3	6	12	18	868.51
#357	SIN3A	6	13	19	1245.651
#358	ZSCAN12	6	6	12	648.272
#359	ZNF287	6	11	17	740.56
#360	ZKSCAN3	6	5	11	837.517
#361	ELK4	6	12	18	1301.019
#362	HOXD1	6	14	20	622.52
#363	HOXA1	6	11	17	543.749
#364	NRL	6	15	21	1359.457
#365	SOX8	6	15	21	1110.952
#366	OLIG2	6	9	15	562.674
#367	SPIC	6	11	17	548.676
#368	RARG	6	11	17	1073.872
#369	BRD8	6	10	16	651.493
#370	ARNT2	6	10	16	2141.185
#371	NR4A1	6	10	16	813.667
#372	FLI1	6	12	18	969.357
#373	HMG20B	6	7	13	769.15
#374	ZIC2	6	13	19	1106.261
#375	TSC22D2	6	11	17	680.659
#376	POU2F1	6	9	15	993.773
#377	IRX5	6	10	16	943.516
#378	CREBBP	6	11	17	587.007
#379	TCF12	6	10	16	837.757
#380	NFIA	6	10	16	989.622
#381	ZNF434	6	10	16	257.237
#382	NOBOX	6	11	17	1164.006
#383	ZNF19	6	10	16	637.1
#384	ZNF93	6	12	18	1559.74
#385	ZNF397	6	10	16	1101.126
#386	PGR	6	8	14	690.159
#387	ZFP42	6	7	13	1042.983
#388	MECOM	6	15	21	843.815
#389	ZSCAN4	6	11	17	1161.438
#390	TSHZ2	6	8	14	640.588
#391	NPAS2	6	14	20	865.765
#392	SIM1	6	14	20	1181.78
#393	GLI3	6	10	16	949.413
#394	GATAD2B	6	7	13	484.425
#395	HOXC9	6	14	20	1348.816
#396	ELK1	6	15	21	1092.111
#397	TBX5	6	13	19	1386.949
#398	TFDP2	6	12	18	851.231
#399	SLC2A4RG	6	12	18	1245.89
#400	CEBPD	5	11	16	615.824
#401	IKZF4	5	13	18	920.742
#402	ASCL1	5	11	16	1765.971
#403	GCM1	5	13	18	1167.611
#404	ZNF81	5	12	17	1115.101
#405	PITX2	5	19	24	488.605
#406	HMGA2	5	15	20	1195.445
#407	POU3F2	5	13	18	1346.754
#408	ANKRD30A	5	10	15	837.696
#409	SIX6	5	12	17	1121.982
#410	CREBZF	5	9	14	694.675
#411	ALS2CR8	5	12	17	1507.211
#412	MYF5	5	13	18	743.07
#413	GSC2	5	8	13	318.147
#414	IKZF1	5	11	16	845.982
#415	TFAP2B	5	11	16	962.731
#416	ZIC3	5	7	12	307.23
#417	DLX3	5	12	17	539.11
#418	MLX	5	8	13	696.543
#419	ZFP36L1	5	11	16	648.082
#420	RUNX1T1	5	11	16	640.5
#421	ELF5	5	11	16	1983.509
#422	DMRT2	5	10	15	867.635
#423	ZNF639	5	8	13	668.259
#424	BACH1	5	11	16	963.49
#425	IRX2	5	12	17	538.014
#426	HLF	5	10	15	1039.485
#427	ONECUT2	5	12	17	739.651
#428	GLIS3	5	14	19	1379.022
#429	BARX1	5	9	14	870.562
#430	ZNF175	5	8	13	661.694
#431	GSX1	5	9	14	640.411
#432	MEOX2	5	16	21	1279.62
#433	TBX19	5	14	19	1534.492
#434	GATA4	5	13	18	1179.251
#435	NFATC4	5	11	16	693.869
#436	ZFHX2	5	14	19	814.855
#437	STAT2	5	14	19	1630.573
#438	ZNF277	4	9	13	634.786
#439	C2orf3	4	8	12	389.759
#440	REST	4	11	15	1135.494
#441	FOXL1	4	8	12	531.41
#442	AFF4	4	9	13	205.409
#443	ZNF154	4	12	16	906.059
#444	TP63	4	15	19	1267.698
#445	RCOR1	4	16	20	1668.464
#446	PCGF2	4	11	15	435.464
#447	PKNOX1	4	11	15	593.575
#448	TEAD1	4	12	16	469.374
#449	ERG	4	12	16	1922.012
#450	DLX2	4	14	18	832.447
#451	POU6F2	4	12	16	568.28
#452	ZNF117	4	11	15	1490.971
#453	TBX22	4	8	12	436.943
#454	TAL1	4	14	18	763.805
#455	NANOG	4	10	14	600.495
#456	GLI2	4	10	14	510.28
#457	POU3F4	4	7	11	291.588
#458	POU4F3	4	8	12	440.96
#459	NFIB	4	12	16	1306.327
#460	VSX1	4	14	18	628.076
#461	LASS5	4	13	17	478.986
#462	PAX8	4	12	16	716.211
#463	ZNF215	4	13	17	1193.474
#464	LHX8	4	13	17	562.541
#465	THRA	4	12	16	926.698
#466	LZTS1	4	11	15	895.267
#467	SIX4	3	12	15	481.624
#468	NPAT	3	10	13	302.726
#469	GATA5	3	10	13	607.069
#470	CRX	3	8	11	275.817
#471	FOXD3	3	13	16	528.419
#472	BCL11B	3	10	13	462.484
#473	PPARA	3	9	12	501.534
#474	ZNF24	3	9	12	334.198
#475	HSF5	3	15	18	409.753
#476	FOXK2	3	10	13	703.967
#477	PTH	3	14	17	522.14
#478	DLX1	3	13	16	888.479
#479	EGR4	3	9	12	577.911
#480	MITF	3	7	10	364.836
#481	ZNF3	3	9	12	293.556
#482	ZNF500	3	12	15	360.654
#483	TBX15	3	15	18	567.832
#484	MGA	2	12	14	233.068
#485	PEG3	2	10	12	337.973
#486	RUNX1	2	9	11	135.693
#487	EPAS1	2	13	15	352.517
#488	KDM5B	2	13	15	295.002
#489	HNRNPAB	2	9	11	354.207
#490	TSC22D3	2	8	10	290.45
#491	SOX6	2	10	12	263.605
#492	MLL	2	16	18	990.798
#493	FOXJ1	2	12	14	269.456
#494	ZNF135	2	11	13	244.844
#495	ZNF85	1	11	12	78.81
#496	ZNF483	1	13	14	383.452
#497	LMX1A	1	14	15	268.825
#498	IRX4	1	13	14	176.734
#499	SMAD3	1	14	15	106.56
#500	ZFHX4	0	12	12	0