Hub Rank	Node	Children	Parents	Degree	Betweenness
#1	MECOM	67	4	71	318.868
#2	TFAP2A	56	0	56	0
#3	ETS2	56	3	59	109.194
#4	IRX5	51	5	56	158.204
#5	TRPS1	49	7	56	705.492
#6	HMGA1	46	6	52	375.051
#7	GATA3	45	9	54	1192.608
#8	ESR1	42	10	52	2135.409
#9	LASS2	40	12	52	18232.887
#10	SATB2	40	5	45	325.632
#11	GATA6	39	8	47	7061.098
#12	KLF5	39	8	47	280.807
#13	PPARG	38	6	44	192.775
#14	FOXF1	38	5	43	495.05
#15	NFE2L3	37	13	50	361.745
#16	FOXA1	37	2	39	60.554
#17	TCF7L1	37	7	44	462.125
#18	AEBP1	36	7	43	325.509
#19	HOXC4	35	6	41	345.853
#20	CDX2	35	5	40	128.25
#21	TFAP2C	35	5	40	752.816
#22	ZBTB38	34	9	43	1773.588
#23	XBP1	33	4	37	255.885
#24	MAFB	32	9	41	3393.204
#25	HOXA10	32	3	35	48.163
#26	ZFPM2	31	6	37	1845.417
#27	RBCK1	31	11	42	613.049
#28	NFIB	31	6	37	1182.303
#29	FOXA2	31	11	42	311.749
#30	HNF1B	30	9	39	1546.533
#31	PLAGL2	30	8	38	365.475
#32	ELF3	29	9	38	2288.113
#33	FOXM1	29	6	35	1617.737
#34	CEBPA	29	10	39	1270.386
#35	CITED2	28	14	42	1281.1
#36	EN1	28	8	36	238.873
#37	SP140	28	9	37	3355.573
#38	SNAI2	28	10	38	2163.549
#39	HINFP	28	17	45	4323.401
#40	FOXO3	27	10	37	5573.007
#41	ESRRA	27	9	36	1111.734
#42	KLF2	27	12	39	1098.862
#43	TFDP1	27	10	37	3287.644
#44	PURA	26	7	33	1230.173
#45	PBX1	26	8	34	1136.209
#46	MEF2C	26	10	36	1508.953
#47	HOXA11	26	6	32	131.386
#48	FOS	26	7	33	3773.054
#49	NR3C1	26	10	36	935.072
#50	HOXA9	26	10	36	190.524
#51	NFIL3	25	6	31	105.845
#52	AR	25	8	33	1741.316
#53	STAT3	25	3	28	1029.021
#54	PRRX1	25	11	36	514.504
#55	HCLS1	25	8	33	1286.508
#56	SOX10	25	4	29	340.279
#57	SIX2	24	15	39	4649.164
#58	MEIS2	24	9	33	959.577
#59	SALL2	24	11	35	1711.269
#60	HMGA2	24	14	38	802.888
#61	SATB1	24	10	34	728.24
#62	HOXB2	23	13	36	1230.205
#63	MBD1	23	16	39	1615.662
#64	FOXC1	23	12	35	3292.166
#65	SPDEF	23	5	28	452.134
#66	CUX1	23	13	36	5212.893
#67	MEIS1	23	6	29	935.236
#68	HNF1A	22	8	30	2447.986
#69	BACH2	22	13	35	877.846
#70	FOXN3	22	10	32	1224.625
#71	LASS6	22	14	36	4509.291
#72	JUNB	22	4	26	526.359
#73	ZNF446	22	9	31	451.506
#74	MEIS3P1	22	10	32	274.61
#75	HOXC10	22	11	33	489.396
#76	ARNTL2	21	11	32	435.102
#77	SREBF1	21	7	28	202.484
#78	GRHL2	21	12	33	2167.55
#79	JUND	21	9	30	1369.099
#80	ARNT2	21	18	39	1315.889
#81	BCL6	21	9	30	1591.636
#82	TWIST1	20	9	29	1811.534
#83	BCL11B	20	15	35	933.874
#84	STAT1	20	3	23	277.389
#85	PEG3	20	15	35	2120.737
#86	GATA2	20	11	31	800.488
#87	FLI1	20	12	32	1427.884
#88	BHLHE40	19	13	32	2200.693
#89	HMG20B	19	10	29	603.29
#90	ARNTL	19	14	33	5904.88
#91	SLC26A3	19	9	28	145.506
#92	TEAD4	19	9	28	407.665
#93	ETV1	19	15	34	1446.986
#94	ETV5	19	14	33	1088.798
#95	HOXC13	19	12	31	690.041
#96	HOXA7	18	9	27	337.795
#97	NR1I2	18	9	27	864.609
#98	KLF6	18	7	25	826.001
#99	EGR3	18	11	29	910.578
#100	RUNX3	18	12	30	816.006
#101	IRF9	18	12	30	1157.448
#102	MYC	18	12	30	1248.921
#103	E2F8	18	12	30	500.965
#104	E2F4	18	11	29	630.51
#105	ZFHX4	18	15	33	1356.797
#106	IKZF1	18	9	27	448.941
#107	ZEB2	18	8	26	327.741
#108	TCF4	18	11	29	897.147
#109	ZNF165	18	17	35	1487.67
#110	TRIM22	18	7	25	828.175
#111	NR4A3	18	11	29	1324.596
#112	HOXB5	18	8	26	317.342
#113	ELK3	18	10	28	488.376
#114	NR3C2	17	15	32	1287.216
#115	LHX6	17	14	31	848.88
#116	PTTG1	17	9	26	623.895
#117	HEY2	17	13	30	4904.314
#118	EGR2	17	13	30	648.396
#119	ZEB1	17	10	27	1360.172
#120	HEY1	17	16	33	1415.085
#121	MEOX1	17	12	29	981.447
#122	HOXB9	16	12	28	822.634
#123	NFATC4	16	14	30	948.976
#124	HAND1	16	3	19	79.359
#125	PHF1	16	13	29	331.973
#126	ZKSCAN1	16	5	21	258.281
#127	AFF1	16	14	30	2233.76
#128	HOXA5	16	16	32	2064.675
#129	ZFP36L1	15	13	28	717.868
#130	BTG2	15	11	26	1245.367
#131	ZNF236	15	11	26	1288.466
#132	PPARA	15	11	26	283.845
#133	SMAD3	15	12	27	2880.192
#134	TFEC	15	15	30	1098.835
#135	ZNF238	15	16	31	3321.824
#136	SIM2	15	12	27	445.761
#137	SPEN	15	13	28	1417.299
#138	IRF4	15	11	26	912.624
#139	SOX4	15	14	29	1545.933
#140	IRF6	15	12	27	3647.484
#141	ARID3A	15	14	29	413.151
#142	MITF	15	12	27	790.181
#143	FOXF2	15	9	24	154.628
#144	TFEB	15	13	28	19665.288
#145	FOSB	14	5	19	273.206
#146	LMO4	14	11	25	317.189
#147	HOXC11	14	9	23	871.124
#148	ELF5	14	13	27	720.454
#149	MAF	14	7	21	356.329
#150	SIX3	14	11	25	1174.934
#151	MEF2A	14	13	27	680.6
#152	IRX4	14	11	25	400.513
#153	PBX3	14	18	32	705.56
#154	NR4A1	14	7	21	444.299
#155	TBX3	14	12	26	1218.306
#156	PROX1	14	16	30	562.112
#157	RUNX1T1	14	12	26	651.673
#158	CBFA2T3	14	11	25	384.243
#159	AHR	14	13	27	394.934
#160	PLAG1	14	14	28	994.906
#161	NKX3-2	14	13	27	2335.581
#162	RXRA	14	15	29	3625.885
#163	EVX1	14	12	26	1388.915
#164	TBX19	14	8	22	928.715
#165	TCEAL1	13	10	23	497.376
#166	TFAP2B	13	17	30	834.804
#167	ESRRG	13	12	25	848.321
#168	BHLHE41	13	16	29	3955.874
#169	ZNF167	13	21	34	4306.975
#170	HOXB7	13	15	28	3781.379
#171	SMAD6	13	17	30	2060.842
#172	POU5F1B	13	13	26	730.635
#173	TSC22D3	13	13	26	1034.286
#174	SOX9	13	11	24	1580.226
#175	ISL1	13	17	30	1682.885
#176	BATF	13	9	22	927.466
#177	POU6F1	13	18	31	790.927
#178	VENTX	13	14	27	1922.126
#179	HOXD4	13	16	29	2791.041
#180	DLX4	13	16	29	2537.869
#181	TFCP2L1	13	17	30	542.259
#182	HHEX	13	11	24	675.075
#183	AFF4	13	11	24	1419.203
#184	ATF3	12	8	20	382.848
#185	KLF1	12	12	24	2373.491
#186	ETV4	12	13	25	902.955
#187	RORA	12	7	19	1467.908
#188	ZNF83	12	11	23	322.114
#189	C11orf9	12	11	23	619.008
#190	SOX11	12	17	29	1720.953
#191	EGR1	12	8	20	234.332
#192	SLC2A4RG	12	15	27	1394.874
#193	MNX1	12	14	26	1248.447
#194	ZBTB48	12	17	29	2004.981
#195	MYCL1	12	17	29	5352.92
#196	MYBL2	12	12	24	437.473
#197	ZNF93	12	14	26	1085.783
#198	GCM1	12	14	26	3150.714
#199	SP1	12	14	26	3295.421
#200	ZNF91	12	14	26	2684.355
#201	PAX6	12	16	28	2257.096
#202	IRF8	12	14	26	917.548
#203	PITX2	12	13	25	791.213
#204	FOXG1	12	14	26	1173.832
#205	SUPT6H	12	13	25	1378.692
#206	FOXI1	12	15	27	969.019
#207	HOXA4	12	13	25	2939.959
#208	TSC22D2	11	17	28	2478.641
#209	LHX2	11	11	22	1585.624
#210	ZNF323	11	13	24	723.107
#211	FUBP1	11	19	30	1081.19
#212	GATA1	11	11	22	1290.779
#213	SCML1	11	15	26	2174.386
#214	LZTS1	11	14	25	1035.246
#215	RUNX2	11	10	21	677.228
#216	EMX1	11	13	24	1850.664
#217	ZNF132	11	18	29	1270.877
#218	PRRX2	11	11	22	644.965
#219	ZIC1	11	10	21	1127.063
#220	BNC1	11	13	24	2442.198
#221	HOXA6	11	12	23	1729.307
#222	CUX2	11	13	24	1847.916
#223	MYT1L	11	12	23	1040.281
#224	ATOH1	11	13	24	607.436
#225	ZNF45	11	11	22	936.933
#226	HOPX	11	17	28	504.178
#227	NFKB2	11	20	31	2666.549
#228	TCF15	11	10	21	798.824
#229	NKX2-1	11	13	24	2052.52
#230	SP4	11	14	25	2080.844
#231	WNT5A	10	14	24	816.773
#232	TFDP2	10	15	25	1685.596
#233	ZNF639	10	11	21	1240.17
#234	TAF12	10	13	23	2198.075
#235	KLF9	10	20	30	1976.584
#236	NR2E1	10	10	20	1019.966
#237	IRF7	10	10	20	1340.111
#238	BCL3	10	13	23	613.515
#239	GATA4	10	15	25	3342.813
#240	MZF1	10	12	22	2329.766
#241	TCF7	10	15	25	1678.96
#242	ATF6B	10	13	23	1715.553
#243	HR	10	12	22	927.333
#244	GAS7	10	13	23	274.507
#245	ZNF500	10	12	22	1866.567
#246	MEOX2	10	14	24	307.507
#247	TBX10	10	8	18	987.128
#248	GABPB1	10	17	27	4333.01
#249	ZNF134	10	10	20	1147.951
#250	TCF21	10	7	17	1615.24
#251	ZNF117	10	14	24	1563.929
#252	NR4A2	10	15	25	1155.315
#253	ZNF135	10	13	23	719.406
#254	E2F1	10	6	16	536.348
#255	TFAP4	10	17	27	1104.087
#256	HOXD9	9	10	19	576.344
#257	NFATC3	9	11	20	1170.388
#258	ZNF174	9	17	26	1507.081
#259	NFIC	9	9	18	200.863
#260	ERG	9	15	24	918.696
#261	CTBP1	9	12	21	1307.731
#262	MAX	9	12	21	1760.749
#263	NKX3-1	9	12	21	2327.724
#264	ATF6	9	9	18	1208.887
#265	TFAM	9	14	23	427.187
#266	MTF1	9	8	17	1086.862
#267	SIX1	9	14	23	328.83
#268	ZNF444	9	15	24	1964.544
#269	ZXDC	9	14	23	1650.843
#270	PTH	9	13	22	1156.383
#271	CEBPD	9	13	22	1078.555
#272	HOXC5	9	16	25	877.167
#273	TBX1	9	13	22	1116.208
#274	MAFF	9	13	22	900.703
#275	SALL1	9	13	22	1426.609
#276	NR1D2	9	14	23	826.266
#277	RARG	9	15	24	1145.662
#278	MAFK	9	14	23	6871.06
#279	ASCL1	9	16	25	1654.013
#280	NR2F1	9	19	28	584.043
#281	BRD8	9	14	23	2526.223
#282	PAX5	9	9	18	1033.727
#283	HSF2	9	15	24	1693.06
#284	VDR	9	15	24	2608.09
#285	ZFP37	9	15	24	3678.546
#286	SOX13	9	15	24	240.015
#287	OVOL1	9	12	21	1245.24
#288	MLXIPL	9	12	21	3874.629
#289	DLX2	9	15	24	1011.109
#290	NEUROG1	9	14	23	1761.974
#291	TP53	9	13	22	2325.034
#292	EPAS1	8	17	25	1107.981
#293	ZSCAN18	8	17	25	376.195
#294	JUN	8	13	21	723.251
#295	MYF6	8	12	20	1432.876
#296	THRB	8	8	16	1675.518
#297	NR2C1	8	16	24	783.371
#298	HOXA1	8	14	22	706.491
#299	NPAT	8	11	19	354.652
#300	ETV2	8	16	24	850.08
#301	CREBZF	8	12	20	1053.397
#302	SOX18	8	17	25	1139.057
#303	CDKN2A	8	13	21	3299.335
#304	SPIB	8	14	22	1962.829
#305	FOXH1	8	15	23	1553.893
#306	LEF1	8	15	23	557.989
#307	PHOX2A	8	10	18	803.833
#308	RCAN1	8	20	28	987.339
#309	DLX6	8	16	24	750.751
#310	NR2E3	8	15	23	865.777
#311	FOSL2	8	12	20	1972.255
#312	HIF3A	8	13	21	1129.218
#313	HOXD11	8	14	22	1279.608
#314	MTA2	8	16	24	1086.677
#315	ZIC3	8	14	22	1201.301
#316	SMAD5	8	17	25	2515.384
#317	NPAS1	8	9	17	909.604
#318	TBX6	8	14	22	1506.721
#319	TADA2A	8	11	19	1036.066
#320	GABPA	8	16	24	862.509
#321	ZNF643	8	13	21	2330.011
#322	HOXB1	8	14	22	1269.423
#323	RXRB	8	16	24	910.839
#324	ZNF202	8	13	21	398.18
#325	TBX2	8	16	24	1087.904
#326	HMBOX1	8	17	25	766.948
#327	ZNF215	8	15	23	208.944
#328	CITED1	8	15	23	511.092
#329	FOXD2	8	16	24	1387.371
#330	ELF4	8	14	22	564.289
#331	EGR4	8	13	21	595.262
#332	ALX4	7	14	21	1532.078
#333	STRN3	7	15	22	478.934
#334	NKX2-5	7	14	21	470.62
#335	STAT2	7	11	18	1025.325
#336	NR6A1	7	14	21	1341.624
#337	HOXD13	7	16	23	910.396
#338	PRDM2	7	12	19	627.247
#339	CREBBP	7	12	19	1289.748
#340	CEBPE	7	10	17	599.617
#341	NR1H4	7	14	21	1343.652
#342	MSC	7	13	20	375.982
#343	TRIM25	7	9	16	1120.072
#344	NR1I3	7	15	22	735.406
#345	PBX2	7	11	18	2538.043
#346	NR2F2	7	20	27	1058.549
#347	TCF7L2	7	14	21	530.695
#348	RB1	7	12	19	474.048
#349	IKZF3	7	14	21	686.585
#350	ZFHX3	7	16	23	1068.777
#351	MYT1	7	9	16	500.738
#352	MLLT10	7	13	20	653.623
#353	NR0B1	7	14	21	1009.586
#354	CBFA2T2	7	16	23	894.399
#355	PGR	7	12	19	127.373
#356	ZHX3	7	15	22	1320.093
#357	GSC2	7	11	18	890.192
#358	HESX1	7	17	24	2170.423
#359	EN2	7	10	17	1117.137
#360	TBX5	7	12	19	608.641
#361	BARX1	7	11	18	2082.086
#362	HOXB6	7	12	19	617.929
#363	PITX1	7	18	25	589.142
#364	KLF12	7	16	23	1391.727
#365	ZNF287	6	21	27	1215.819
#366	ST18	6	17	23	2329.356
#367	HOXD3	6	9	15	498.03
#368	PKNOX2	6	13	19	814.832
#369	TADA3	6	10	16	448.336
#370	THRA	6	7	13	440.303
#371	HNF4A	6	12	18	879.11
#372	NPAS2	6	16	22	121.36
#373	CREB3L1	6	16	22	1440.874
#374	CRX	6	14	20	994.203
#375	ELK4	6	16	22	4138.071
#376	REST	6	18	24	1898.558
#377	ERF	6	15	21	624.543
#378	WT1	6	18	24	889.2
#379	C2orf3	6	15	21	3187.333
#380	ONECUT2	6	8	14	404.178
#381	ETS1	6	17	23	980.291
#382	DMRT1	6	13	19	418.516
#383	SRF	6	11	17	917.453
#384	MEF2D	6	12	18	337.531
#385	TCF3	6	13	19	394.605
#386	TAF1B	6	9	15	360.491
#387	SIM1	6	14	20	1189.449
#388	ATF5	6	14	20	994.215
#389	MXD1	6	10	16	275.256
#390	SRY	6	16	22	754.328
#391	SPI1	6	13	19	1154.667
#392	TEF	6	14	20	931.581
#393	GLI2	6	11	17	866.26
#394	NEUROD1	6	19	25	1248.347
#395	FOXL2	6	14	20	1415.037
#396	HOXC8	6	14	20	1829.183
#397	MMP14	6	14	20	368.478
#398	ALX3	6	15	21	820.162
#399	HOXB3	6	17	23	2966.87
#400	ZNF41	6	12	18	804.012
#401	PRDM1	6	16	22	1008.428
#402	HAND2	6	10	16	1257.79
#403	SOX2	5	13	18	487.553
#404	PKNOX1	5	11	16	1154.533
#405	NFE2	5	14	19	1192.977
#406	TLX3	5	11	16	2616.804
#407	NANOG	5	12	17	460.686
#408	MLL	5	14	19	762.084
#409	SOX21	5	15	20	1124.65
#410	PAX8	5	14	19	622.765
#411	PPARD	5	16	21	790.216
#412	GBX2	5	18	23	1793.156
#413	FOXE1	5	11	16	1208.956
#414	HNF4G	5	9	14	108.515
#415	PAX7	5	18	23	1488.809
#416	TP63	5	10	15	1536.897
#417	POU2F3	5	15	20	1157.749
#418	PAX4	5	11	16	1467.73
#419	SOX5	5	18	23	8826.545
#420	TBR1	5	10	15	581.521
#421	FOXC2	5	15	20	1121.565
#422	FOXJ1	5	14	19	508.703
#423	VAX2	5	18	23	2342.694
#424	HOXA2	5	12	17	182.393
#425	ZNF157	5	17	22	1149.614
#426	POU4F1	5	15	20	1232.668
#427	MSRB2	5	20	25	1080.246
#428	NR5A2	5	11	16	242.515
#429	HSF4	5	12	17	231.161
#430	EHF	5	14	19	280.019
#431	MYCN	5	19	24	1297.354
#432	TRIM29	5	17	22	371.368
#433	FOXO4	4	8	12	243.837
#434	ARNT	4	17	21	624.299
#435	RUNX1	4	13	17	600.128
#436	RARA	4	13	17	566.451
#437	KLF15	4	12	16	538.741
#438	ZNF3	4	12	16	659.454
#439	RERE	4	16	20	775.494
#440	HOXA3	4	11	15	538.473
#441	BATF3	4	24	28	447.204
#442	YY1	4	13	17	206.631
#443	RARB	4	10	14	331.031
#444	ZNF154	4	12	16	751.75
#445	RBPJL	4	17	21	1134.197
#446	PDX1	4	14	18	1022.136
#447	SNAPC5	4	18	22	1393.703
#448	CREM	4	20	24	520.144
#449	TCF12	4	16	20	1320.096
#450	T	4	12	16	473.357
#451	KLF4	4	15	19	286.276
#452	SMAD1	4	15	19	712.08
#453	POU3F4	4	10	14	400.854
#454	FOXN2	4	19	23	687.065
#455	MYF5	4	15	19	1196.925
#456	FOSL1	4	12	16	130.296
#457	HMX1	4	10	14	425.955
#458	FOXE3	4	12	16	919.393
#459	HOXB13	4	14	18	240.451
#460	PPBPL2	4	15	19	634.172
#461	SCRT1	4	12	16	1006.894
#462	POU3F2	4	15	19	1523.467
#463	POU2F2	4	15	19	618.706
#464	HOXB8	3	12	15	659.366
#465	ONECUT1	3	18	21	1020.647
#466	ZNF81	3	15	18	454.773
#467	NFAT5	3	20	23	425.081
#468	PAX3	3	12	15	244.76
#469	SCAND2	3	14	17	841.248
#470	PHOX2B	3	14	17	402.445
#471	VTN	3	16	19	799.491
#472	ELK1	3	12	15	680.623
#473	MSX2	3	16	19	607.174
#474	POU3F3	3	15	18	661.632
#475	RFXAP	3	15	18	629.392
#476	MYOD1	3	16	19	317.052
#477	FOXD1	3	17	20	228.595
#478	OLIG2	3	14	17	652.86
#479	E2F2	3	14	17	710.543
#480	SNAPC4	3	14	17	387.443
#481	NFIX	3	12	15	716.056
#482	NFX1	3	18	21	388.343
#483	ZFP36L2	3	13	16	341.194
#484	TFDP3	3	13	16	385.632
#485	CSDA	3	13	16	385.236
#486	TAL1	3	15	18	310.899
#487	CREB5	3	15	18	605.926
#488	DBP	3	12	15	539.789
#489	ESR2	3	18	21	513.818
#490	NFATC1	3	15	18	375.881
#491	FOXP3	2	17	19	219.058
#492	HOXD1	2	15	17	403.017
#493	HLF	2	19	21	645.404
#494	NKX2-8	2	16	18	217.375
#495	ZNF155	2	15	17	165.423
#496	POU3F1	2	16	18	251.18
#497	SOX30	2	16	18	440.243
#498	KDM5B	2	19	21	906.451
#499	NR5A1	1	16	17	117.866
#500	ZNF80	1	16	17	109.094