Hub Rank	Node	Children	Parents	Degree	Betweenness
#1	MITF	93	3	96	1925.976
#2	ZBTB38	83	7	90	1078.614
#3	ZFP36L1	75	5	80	339.57
#4	ELK3	70	8	78	1099.541
#5	ETS1	69	9	78	1362.889
#6	KLF5	68	7	75	1743.171
#7	SNAI2	66	5	71	749.028
#8	ZFHX3	57	3	60	331.116
#9	HMGB2	57	6	63	616.813
#10	TFDP2	56	12	68	1079.804
#11	EPAS1	54	8	62	1500.066
#12	HCLS1	54	4	58	493.457
#13	NR2F6	52	14	66	3112.607
#14	LZTS1	52	4	56	167.274
#15	NR3C1	49	15	64	4002.483
#16	CEBPD	48	10	58	597.89
#17	SOX6	48	8	56	472.372
#18	CITED1	47	3	50	34.099
#19	SIX5	47	13	60	1081.597
#20	LEF1	47	10	57	464.152
#21	GAS7	44	10	54	2770.2
#22	MAF	44	13	57	2291.671
#23	KLF4	43	16	59	1024.466
#24	NFIB	43	12	55	958.436
#25	IRF4	43	5	48	1432.412
#26	PCGF2	42	11	53	1061.249
#27	MEIS3P1	42	14	56	2085.588
#28	ZHX2	42	25	67	3414.616
#29	TSC22D1	42	6	48	958.515
#30	FOSL2	42	14	56	1819.994
#31	TCF7L2	41	5	46	493.023
#32	E2F2	40	6	46	203.517
#33	IKZF1	40	8	48	587.867
#34	GLIS2	40	7	47	491.4
#35	BCL6	39	15	54	2003.161
#36	MYBL2	39	1	40	381.2
#37	HEY1	39	10	49	1246.81
#38	ZEB2	38	15	53	978.428
#39	FOXQ1	38	8	46	885.709
#40	NFATC3	38	9	47	400.348
#41	ELF3	38	14	52	2854.969
#42	ZEB1	38	14	52	579.225
#43	FLI1	38	12	50	898.035
#44	SCML1	38	14	52	1746.879
#45	XBP1	38	12	50	1007.651
#46	MTA3	38	11	49	849.1
#47	TEAD1	37	6	43	466.569
#48	ZNF238	36	15	51	1586.034
#49	ZFP36L2	36	18	54	4506.822
#50	BHLHE40	36	16	52	1313.247
#51	SOX9	35	13	48	1069.475
#52	IRF6	35	2	37	103.054
#53	BCL3	35	7	42	479.562
#54	ARNT2	35	11	46	869.348
#55	SOX4	35	18	53	3707.791
#56	VAV1	35	13	48	2033.487
#57	TCF4	34	15	49	1021.896
#58	HMG20B	34	13	47	624.683
#59	UHRF1	34	8	42	421.627
#60	ZNF33A	34	9	43	673.331
#61	ETV5	33	14	47	1266.552
#62	E2F8	33	4	37	194.706
#63	EHF	32	10	42	617.938
#64	GLIS3	32	11	43	486.839
#65	IRX3	32	10	42	1269.463
#66	JUN	32	18	50	3175.364
#67	MECOM	31	11	42	1273.027
#68	HOXA3	31	14	45	1469.714
#69	MEF2C	31	17	48	2311.525
#70	PBX3	31	14	45	2711.809
#71	NFXL1	31	13	44	2747.441
#72	SATB2	31	20	51	3259.143
#73	NFIC	30	14	44	1436.865
#74	ZNF165	30	5	35	934.475
#75	MEIS1	30	19	49	5336.269
#76	MYC	30	6	36	541.563
#77	GTF2IRD1	30	11	41	1632.464
#78	HNF4G	30	13	43	1663.161
#79	GATA3	29	15	44	1445.529
#80	SATB1	29	17	46	622.381
#81	NR2F2	29	17	46	992.622
#82	ETS2	28	15	43	2877.22
#83	CREB3L4	28	8	36	324.479
#84	FOXP1	28	14	42	2226.639
#85	RB1	28	12	40	2471.596
#86	SIX4	28	16	44	1298.878
#87	NFIX	28	12	40	1490.311
#88	ETV4	27	15	42	1192.78
#89	EBF1	27	13	40	2310.111
#90	KDM5B	27	17	44	1574.581
#91	TCEAL1	27	12	39	1685.555
#92	ASCL2	27	7	34	1264.28
#93	HOXA5	27	7	34	689.41
#94	MAFF	27	20	47	1299.905
#95	ARID3A	26	14	40	1307.804
#96	CITED2	26	18	44	1664.852
#97	HMGB1	26	13	39	1433.57
#98	NKX3-1	26	19	45	2461.656
#99	E2F3	26	15	41	1575.859
#100	SOX10	26	4	30	40.813
#101	JDP2	25	11	36	1156.1
#102	RUNX1	25	25	50	2973.665
#103	HOXA9	25	11	36	925.652
#104	FOXA1	25	12	37	2013.13
#105	ALX1	25	11	36	631.181
#106	HMGA2	25	15	40	930.129
#107	TFAP2A	24	20	44	1415.672
#108	YEATS4	24	15	39	725.847
#109	PBX1	24	26	50	2023.868
#110	C1orf85	24	13	37	672.404
#111	PPARG	24	12	36	803.452
#112	FOXN2	24	15	39	1355.959
#113	NOTCH1	24	14	38	788.845
#114	STAT5B	23	12	35	910.745
#115	GRHL2	23	4	27	74.222
#116	IRX5	23	17	40	1473.872
#117	RUNX2	23	18	41	1081.417
#118	FOXD1	23	22	45	1389.885
#119	TAF4B	23	13	36	1473.374
#120	ESRRA	23	18	41	1773.314
#121	TCF3	22	16	38	2633.468
#122	FUBP1	22	16	38	1785.571
#123	NR1H3	22	11	33	611.997
#124	FOSL1	22	17	39	1513.299
#125	NPAT	22	10	32	2263.261
#126	GATA6	22	17	39	1345.327
#127	RXRG	22	5	27	72.483
#128	NR4A3	22	6	28	44.298
#129	TEAD2	22	12	34	352.311
#130	ZNF193	22	16	38	1692.933
#131	RFXAP	21	16	37	1563.749
#132	FOXG1	21	19	40	2010.446
#133	SIX1	21	23	44	1600.765
#134	ZC3H8	21	16	37	923.746
#135	FOXO1	21	13	34	1508.958
#136	TEAD4	21	22	43	2945.21
#137	ZNF323	20	11	31	407.611
#138	KLF9	20	20	40	944.765
#139	RCAN1	20	13	33	1102.191
#140	KLF3	20	19	39	1285.424
#141	TWIST1	20	20	40	1115.671
#142	ELF1	20	14	34	1249.155
#143	NPAS2	20	20	40	1246.654
#144	IRF9	20	16	36	1002.621
#145	ZNF117	20	22	42	5875.173
#146	KLF12	20	16	36	1036.859
#147	NFIL3	19	17	36	816.045
#148	BHLHE41	19	20	39	1113.559
#149	RXRA	19	19	38	968.208
#150	PRDM1	19	14	33	1258.376
#151	AFF1	19	22	41	2073.504
#152	ETV6	19	15	34	683.639
#153	POU3F2	19	16	35	1312.751
#154	ZNF217	19	20	39	2446.52
#155	RUNX3	19	15	34	1532.433
#156	PAX8	19	14	33	1254.233
#157	ZNF367	19	4	23	259.798
#158	JUNB	18	17	35	1111.324
#159	NOLC1	18	12	30	1148.528
#160	TAF5	18	13	31	328.325
#161	OVOL1	18	5	23	120.928
#162	HIF1A	18	17	35	2871.626
#163	STAT6	18	13	31	1397.538
#164	EN1	18	8	26	417.337
#165	HEY2	18	18	36	2424.316
#166	SCAND3	18	22	40	1957.447
#167	RCOR1	18	14	32	2120.098
#168	FOXA3	17	14	31	995.41
#169	HOXD11	17	11	28	1254.009
#170	WNT5A	17	21	38	1784.195
#171	HOXA10	17	13	30	945.717
#172	PRRX1	17	14	31	786.933
#173	MSX2	17	14	31	723.252
#174	FOXD3	17	11	28	157.852
#175	SLC30A9	17	18	35	5266.164
#176	ZFHX4	17	12	29	505.466
#177	CSRNP1	16	16	32	1078.914
#178	TRIM22	16	19	35	1784.554
#179	HOXB3	16	19	35	807.341
#180	SALL1	16	17	33	753.444
#181	HOXB6	16	11	27	1246.85
#182	NR4A2	16	21	37	2255.639
#183	HOXA2	16	14	30	550.068
#184	HMGA1	16	19	35	1367.174
#185	KLF11	16	15	31	1207.991
#186	ELF4	16	29	45	1476.975
#187	PTTG1	16	11	27	864.618
#188	FOXM1	16	6	22	1292.202
#189	KLF10	16	14	30	305.702
#190	IRF1	16	16	32	483.063
#191	SPDEF	16	8	24	500.302
#192	NFYB	16	24	40	1848.546
#193	ZNF92	16	13	29	689.292
#194	HNF1B	16	11	27	588.429
#195	ZNF138	16	17	33	732.604
#196	SMAD4	15	13	28	762.571
#197	TAL1	15	8	23	649.243
#198	ZSCAN16	15	18	33	1295.81
#199	PLSCR1	15	19	34	1435.442
#200	STAT4	15	18	33	1018.815
#201	FOS	15	18	33	893.611
#202	STAT5A	15	14	29	384.833
#203	GATA2	15	12	27	986.523
#204	C11orf9	15	22	37	2060.816
#205	CDKN2A	15	22	37	2484.204
#206	ATF5	15	9	24	337.516
#207	PGR	15	6	21	116.498
#208	CREB3L2	15	24	39	1321.92
#209	RFX5	15	21	36	915.337
#210	TRERF1	15	22	37	2461.352
#211	TBX2	14	12	26	245.699
#212	SOX2	14	15	29	1312.443
#213	SOX5	14	10	24	267.137
#214	SIM2	14	10	24	792.048
#215	FOXF1	14	12	26	1062.863
#216	NFE2	14	9	23	420.89
#217	TRPS1	14	26	40	1433.494
#218	ZSCAN18	14	21	35	1850.878
#219	SMAD6	14	17	31	680.271
#220	TGIF1	14	18	32	874.396
#221	HES6	14	20	34	1027.188
#222	GTF2H4	14	7	21	632.542
#223	PAX3	14	12	26	287.725
#224	HOXD10	14	17	31	488.582
#225	CREM	14	19	33	703.456
#226	TCFL5	14	18	32	660.055
#227	PAX6	14	23	37	1731.986
#228	HOXB5	14	8	22	954.199
#229	BCL11B	14	18	32	2453.113
#230	SOX17	13	8	21	299.558
#231	ZNF140	13	14	27	1228.47
#232	HOXA13	13	23	36	1997.623
#233	CBFA2T3	13	10	23	661.798
#234	TWIST2	13	19	32	899.804
#235	MAFB	13	20	33	1193.707
#236	SMAD3	13	14	27	295.163
#237	ZNF33B	13	19	32	542.766
#238	ZNF91	13	19	32	673.132
#239	IRX1	13	9	22	341.396
#240	PITX2	13	20	33	615.906
#241	ZNF281	13	8	21	1083.704
#242	DLX1	13	26	39	1405.042
#243	SIX3	13	8	21	249.47
#244	PPARD	12	21	33	651.168
#245	NR2F1	12	26	38	1180.305
#246	DDIT3	12	17	29	823.121
#247	ZNF134	12	15	27	373.617
#248	TCF19	12	12	24	1281.48
#249	DBP	12	21	33	1678.986
#250	ZNF83	12	17	29	854.62
#251	SLC2A4RG	12	19	31	341.299
#252	SMAD2	12	19	31	2569.225
#253	KLF6	12	15	27	550.151
#254	ZNF397	12	17	29	513.716
#255	CEBPA	12	14	26	1191.4
#256	LASS6	12	16	28	1993.107
#257	PURB	12	0	12	0
#258	NCOR1	12	25	37	2035.483
#259	TGIF2	12	19	31	1566.054
#260	MSC	12	23	35	1277.074
#261	TSHZ1	11	27	38	1044.393
#262	CREBL2	11	23	34	838.036
#263	MXD1	11	20	31	649.883
#264	SP4	11	21	32	1316.184
#265	STAT3	11	19	30	1134.994
#266	ZNF274	11	23	34	1380.099
#267	TFAM	11	19	30	1281.373
#268	PKNOX2	11	10	21	194.821
#269	SALL2	11	21	32	1129.083
#270	FOXC2	11	16	27	1296.103
#271	HOXB7	11	24	35	1370.813
#272	CREBZF	11	17	28	871.783
#273	ESRRG	11	10	21	932.247
#274	RBCK1	11	16	27	1160.78
#275	ZFPM2	11	22	33	833.905
#276	TFDP1	11	17	28	467.222
#277	BTG2	11	19	30	1483.615
#278	GLI3	11	20	31	887.222
#279	ZNF496	11	26	37	1699.8
#280	MLLT10	11	21	32	1195.857
#281	CDX2	11	12	23	314.738
#282	LMO4	11	23	34	1668.016
#283	CREB3L1	11	16	27	561.831
#284	TSHZ3	11	12	23	238.097
#285	ISL1	11	12	23	1171.248
#286	MEOX1	11	6	17	475.988
#287	PURA	11	5	16	164.761
#288	TRIM29	10	20	30	938.265
#289	NKX2-1	10	17	27	760.983
#290	E2F7	10	21	31	845.165
#291	EGR3	10	12	22	213.014
#292	BATF3	10	13	23	730.992
#293	SOX8	10	19	29	806.349
#294	FOXN3	10	23	33	1148.571
#295	EN2	10	16	26	149.846
#296	PHTF1	10	21	31	688.462
#297	AHR	10	23	33	474.816
#298	ZNF277	10	20	30	809.387
#299	ZNF131	10	17	27	433.386
#300	HOXA11	10	10	20	153.114
#301	REL	10	19	29	1886.341
#302	TSC22D2	10	24	34	1220.449
#303	MAFK	10	26	36	2194.783
#304	ARID4A	10	17	27	939.288
#305	EGR1	10	21	31	581.051
#306	ZNF175	10	23	33	1457.198
#307	RUNX1T1	10	13	23	495.883
#308	ARNTL	9	21	30	1487.725
#309	DRAP1	9	20	29	689.606
#310	CREB5	9	15	24	711.652
#311	RELB	9	10	19	285.064
#312	MYCN	9	18	27	946.491
#313	FOXF2	9	25	34	1652.031
#314	DMRT1	9	4	13	121.75
#315	HOXB8	9	10	19	729.728
#316	MLL	9	24	33	2756.084
#317	HHEX	9	28	37	1763.878
#318	HOXA1	9	16	25	334.525
#319	NFE2L3	9	24	33	991.74
#320	ARNTL2	9	17	26	779.718
#321	C5orf41	9	17	26	364.013
#322	TBX15	9	19	28	753.53
#323	HOXB2	9	30	39	1704.022
#324	CUX1	9	23	32	1765.824
#325	ZFP90	9	22	31	929.95
#326	PGBD1	9	27	36	1306.225
#327	PA2G4	9	17	26	1300.5
#328	BNC1	9	17	26	1166.792
#329	IRF5	9	17	26	674.41
#330	FOXE1	9	16	25	1185.801
#331	TCF7L1	9	22	31	793.425
#332	TFAP2C	9	25	34	692.036
#333	FOXA2	9	21	30	1038.029
#334	TCF7	8	6	14	148.276
#335	TEAD3	8	23	31	569.352
#336	TCF12	8	11	19	224.902
#337	DLX6	8	17	25	667.117
#338	MSRB2	8	21	29	433.006
#339	HOXA4	8	13	21	659.815
#340	ZNF85	8	19	27	754.28
#341	TSHZ2	8	6	14	225.246
#342	ZNF268	8	22	30	4239.168
#343	MEIS2	8	28	36	3678.894
#344	SIM1	8	18	26	545.586
#345	TAF5L	8	18	26	682.228
#346	NR2C1	8	22	30	1393.853
#347	IRF7	8	21	29	893.141
#348	SOX7	8	15	23	361.382
#349	STAT2	8	16	24	732.554
#350	LHX9	8	11	19	1396.665
#351	ZNF232	8	25	33	737.57
#352	ATF7	8	26	34	1267.128
#353	CSRNP2	8	22	30	716.486
#354	ZKSCAN1	8	23	31	875.324
#355	PPARA	8	20	28	902.185
#356	SCAND1	7	10	17	318.666
#357	STAT1	7	17	24	483.432
#358	ONECUT2	7	19	26	584.248
#359	RERE	7	18	25	450.202
#360	PITX1	7	22	29	1141.395
#361	GATAD1	7	18	25	975.006
#362	SP140	7	15	22	602.821
#363	TFCP2L1	7	18	25	577.217
#364	GATA1	7	4	11	86.147
#365	SOX13	7	23	30	896.332
#366	GRHL3	7	15	22	317.261
#367	ZNF207	7	22	29	1191.682
#368	CCRN4L	7	20	27	788.571
#369	ZNF643	7	19	26	1566.217
#370	SPEN	7	20	27	1354.26
#371	NFAT5	7	11	18	1249.18
#372	TP53	7	24	31	2033.72
#373	STRN3	7	21	28	831.303
#374	TSC22D3	7	22	29	1549.201
#375	LCOR	7	19	26	428.986
#376	C12orf28	7	19	26	541.87
#377	ARX	7	10	17	368.139
#378	CBL	7	14	21	990.579
#379	MYCL1	7	20	27	870.673
#380	PEG3	7	14	21	646.627
#381	HOXC9	7	23	30	1006.975
#382	MKX	7	26	33	1141.456
#383	LHX2	7	17	24	1172.622
#384	HOXD8	7	25	32	1535.996
#385	E2F5	6	29	35	1712.078
#386	OLIG2	6	16	22	521.368
#387	NFIA	6	26	32	288.471
#388	ELF5	6	12	18	210.514
#389	ZNF256	6	23	29	515.494
#390	HOXD1	6	16	22	611.337
#391	VTN	6	9	15	464.907
#392	HOPX	6	16	22	384.823
#393	MEF2A	6	18	24	360.652
#394	ZFP37	6	19	25	1148.103
#395	DLX2	6	20	26	525.491
#396	C2orf3	6	23	29	465.902
#397	HOXD13	6	18	24	723.371
#398	NR0B1	6	20	26	563.137
#399	FOXC1	6	24	30	4383.021
#400	FOXL2	6	24	30	710.325
#401	SOX11	6	22	28	1206.777
#402	AR	6	23	29	967.965
#403	CEBPB	6	20	26	776.161
#404	ETV1	6	19	25	528.04
#405	KLF7	6	24	30	627.441
#406	MEOX2	6	18	24	414.235
#407	MTA1	6	20	26	1421.977
#408	ELK4	6	21	27	764.862
#409	HR	6	22	28	1020.219
#410	SMAD9	6	16	22	883.446
#411	USF1	6	18	24	380.742
#412	ALS2CR8	6	22	28	878.683
#413	TFE3	5	18	23	822.184
#414	WT1	5	25	30	391.963
#415	HIRA	5	23	28	246.364
#416	HSF2	5	21	26	286.503
#417	ZIC1	5	28	33	826.369
#418	ZIC2	5	30	35	1260.54
#419	HOXB13	5	6	11	60.984
#420	TBX3	5	21	26	195.473
#421	GTF2H2	5	27	32	1470.077
#422	RORC	5	11	16	436.679
#423	ZNF93	5	16	21	376.799
#424	PAX7	5	8	13	303.858
#425	NR5A2	5	17	22	916.294
#426	AFF4	5	15	20	499.057
#427	CBFB	5	17	22	727.33
#428	YY1	5	14	19	535.476
#429	BACH2	5	20	25	204.363
#430	ESR1	5	10	15	498.233
#431	ATF3	5	26	31	568.901
#432	HOXD4	5	15	20	217.162
#433	ERG	5	13	18	275.896
#434	MBD1	5	21	26	713.532
#435	MAFG	5	20	25	892.314
#436	HOXD3	4	12	16	328.912
#437	L3MBTL4	4	18	22	353.928
#438	SMAD1	4	17	21	306.285
#439	BACH1	4	29	33	1017.998
#440	AEBP1	4	21	25	539.029
#441	CBFA2T2	4	20	24	1227.487
#442	VDR	4	26	30	295.314
#443	HMBOX1	4	21	25	1859.964
#444	TP63	4	18	22	536.849
#445	NFATC2	4	23	27	157.268
#446	MSX1	4	29	33	380.414
#447	TFCP2	4	19	23	279.206
#448	NKX2-5	4	11	15	588.5
#449	CTNNB1	4	18	22	122.241
#450	RORA	4	22	26	749.557
#451	ISL2	4	18	22	509.874
#452	NR1D2	4	24	28	500.798
#453	HOXC10	4	26	30	380.43
#454	ZNF167	4	32	36	562.53
#455	KDM5A	4	17	21	242.204
#456	ZHX3	4	22	26	960.39
#457	RARB	4	23	27	493.404
#458	POU4F1	4	20	24	536.207
#459	HOXB9	4	16	20	166.191
#460	KLF2	4	24	28	781.328
#461	ATF6	4	18	22	885.89
#462	ZNF174	3	16	19	72.772
#463	FOXL1	3	15	18	503.239
#464	NR2E1	3	14	17	281.69
#465	NR1H4	3	19	22	316.172
#466	IRF8	3	25	28	566.471
#467	NR3C2	3	20	23	288.1
#468	CSRNP3	3	17	20	216.094
#469	HOXA7	3	21	24	424.85
#470	MMP14	3	23	26	714.323
#471	KLF1	3	6	9	76.024
#472	CLOCK	3	20	23	439.497
#473	PROX1	3	17	20	1643.379
#474	CSDA	3	13	16	123.591
#475	LHX8	3	17	20	460.182
#476	ARNT	3	15	18	309.955
#477	NFYA	3	23	26	781.881
#478	TULP4	2	19	21	96.505
#479	FOXR2	2	12	14	180.789
#480	HES1	2	31	33	255.655
#481	DMRT2	2	14	16	611.676
#482	TAF13	2	28	30	477.022
#483	NFKB2	2	19	21	148.357
#484	ZNF70	2	21	23	302.768
#485	RORB	2	15	17	239.512
#486	GTF2I	2	20	22	1013.269
#487	PLAG1	2	28	30	265.899
#488	SUPT4H1	2	21	23	129.561
#489	EGR2	1	28	29	250.545
#490	NFATC1	1	17	18	64.33
#491	TFEB	1	22	23	33.555
#492	FOXP2	1	24	25	92.183
#493	IRX2	1	24	25	345.888
#494	CNOT7	1	27	28	1105.161
#495	MGA	1	23	24	294.565
#496	TBX1	1	11	12	42.092
#497	CTBP1	1	23	24	124.099
#498	ZHX1	1	14	15	98.759
#499	THRB	0	25	25	0
#500	RARA	0	26	26	0