Hub Rank	Node	Children	Parents	Degree	Betweenness
#1	MMP14	42	3	45	4300.849
#2	UHRF1	35	11	46	3624.347
#3	HOXA5	35	7	42	837.007
#4	RUNX1	33	3	36	376.796
#5	ETS1	31	5	36	1149.615
#6	JUN	29	5	34	3953.441
#7	MBD1	29	5	34	407.241
#8	CEBPA	29	6	35	629.035
#9	TSHZ1	29	12	41	870.297
#10	ELK3	28	1	29	654.683
#11	ZNF367	27	5	32	1415.881
#12	PBX1	27	5	32	198.589
#13	FOS	27	6	33	579.886
#14	CREB3L2	26	5	31	506.212
#15	GATA3	26	10	36	685.676
#16	MAF	25	5	30	130.071
#17	SOX4	25	7	32	207.459
#18	FOSL1	24	1	25	14.896
#19	SOX11	23	11	34	1360.286
#20	NR2F6	23	6	29	516.408
#21	HOXA9	23	11	34	1775.552
#22	ELF5	23	7	30	420.953
#23	TFE3	22	6	28	7293.279
#24	NR2F2	22	10	32	477.816
#25	MAFB	22	4	26	81.701
#26	RFX5	21	7	28	258.65
#27	PROX1	21	7	28	2065.74
#28	TULP4	20	9	29	3716.458
#29	EGR2	20	7	27	1417.276
#30	TBX6	20	15	35	2771.818
#31	ZKSCAN3	20	5	25	456.524
#32	HOXA7	20	13	33	2075.254
#33	PHF1	19	9	28	1655.568
#34	FOXD1	19	11	30	1732.277
#35	STAT1	19	12	31	1095.312
#36	SMAD6	19	9	28	1386.186
#37	NFIB	18	12	30	504.119
#38	NFATC3	18	5	23	148.944
#39	MEIS3	18	6	24	313.735
#40	C1orf85	18	12	30	1502.422
#41	HEY1	18	3	21	52.825
#42	ZNF18	17	9	26	402.683
#43	TFEB	17	9	26	752.175
#44	POU3F1	17	11	28	1198.05
#45	TCF7	17	14	31	1687.319
#46	MSRB2	17	10	27	1857.302
#47	POU1F1	17	9	26	4688.279
#48	LEF1	17	9	26	939.738
#49	DBP	16	8	24	2480.2
#50	POU2F2	16	12	28	1166.009
#51	FOXP3	16	7	23	1426.836
#52	GSX2	16	6	22	99.177
#53	SOX15	16	9	25	1044.766
#54	CDKN2A	16	6	22	641.03
#55	MEF2D	16	9	25	1613.229
#56	CNOT7	16	9	25	1164.584
#57	ZNF91	16	5	21	930.596
#58	HMX1	16	8	24	1555.412
#59	NR4A2	16	11	27	1012.469
#60	PRDM1	16	8	24	779.087
#61	E2F8	16	13	29	2600.533
#62	KLF17	15	11	26	2855.206
#63	ETV6	15	9	24	3446.103
#64	WNT5A	15	6	21	346.155
#65	MXD1	15	8	23	296.587
#66	PKNOX1	15	9	24	1563.674
#67	SPIC	15	11	26	1750.383
#68	ZIC2	15	10	25	622.842
#69	HEY2	15	7	22	294.452
#70	MTA3	15	9	24	1412.82
#71	NEUROD1	15	12	27	2182.724
#72	ZNF45	15	6	21	1186.204
#73	TEAD2	15	5	20	150.13
#74	VAX2	15	6	21	1163.775
#75	KLF16	15	13	28	1542.14
#76	TEAD4	15	6	21	351.022
#77	RCAN1	15	12	27	3383.297
#78	PRDM2	14	10	24	1027.566
#79	SEBOX	14	4	18	1795.098
#80	ZNF167	14	10	24	1233.987
#81	ARNTL2	14	9	23	1729.559
#82	ARNTL	14	6	20	956.637
#83	PCGF2	14	6	20	1027.144
#84	RORC	14	8	22	1403.437
#85	NFIX	14	12	26	715.205
#86	SOX5	14	7	21	826.642
#87	CEBPD	14	8	22	946.36
#88	ZKSCAN4	14	7	21	240.043
#89	RARA	14	10	24	1451.547
#90	RERE	14	7	21	1059.845
#91	PGBD1	14	12	26	1567.539
#92	ZFP37	14	10	24	1558.087
#93	E2F2	14	11	25	2290.704
#94	TAF13	14	10	24	2491.361
#95	LMO4	14	8	22	1379.256
#96	ZNF140	14	8	22	1873.83
#97	POU4F3	13	10	23	1435.391
#98	SNAPC5	13	9	22	1694.78
#99	OTX2	13	9	22	2360.336
#100	ZKSCAN2	13	7	20	894.472
#101	CSDA	13	13	26	2029.749
#102	CSRNP3	13	12	25	1521.992
#103	GLIS3	13	10	23	921.428
#104	HOXB8	13	8	21	1145.029
#105	LZTS1	13	11	24	740.273
#106	FOXO6	13	10	23	1216.539
#107	GATA1	13	11	24	1437.751
#108	CUX1	13	6	19	915.856
#109	POU5F2	13	8	21	1151.816
#110	HIC1	13	11	24	2572.4
#111	TWIST1	13	8	21	897.129
#112	NR2E3	13	8	21	1223.577
#113	TBX5	13	8	21	1805.852
#114	HOXA10	13	10	23	1154.738
#115	MSX1	13	11	24	1187.869
#116	TFAP2C	12	9	21	235.288
#117	MECOM	12	10	22	703.381
#118	FOXF2	12	9	21	928.741
#119	TCF12	12	9	21	680.802
#120	THRA	12	8	20	1196.534
#121	PAX4	12	9	21	1838.288
#122	ETV7	12	11	23	1402.658
#123	FOXN3	12	14	26	949.527
#124	MEOX1	12	7	19	613.603
#125	MNX1	12	10	22	1085.125
#126	ZNF80	12	10	22	1771.683
#127	ESR2	12	9	21	1161.123
#128	ISX	12	6	18	1083.408
#129	GSC2	12	11	23	1772.343
#130	PLAG1	12	12	24	1161.692
#131	TBX3	12	10	22	535.112
#132	ZFHX2	12	12	24	1527.16
#133	ZNF236	12	8	20	1109.828
#134	ETV5	12	11	23	1772.217
#135	SOX17	12	10	22	1530.868
#136	CUX2	12	11	23	1986.674
#137	GATAD2A	12	11	23	1497.624
#138	HR	12	8	20	1169.854
#139	EGR4	12	8	20	807.582
#140	ESX1	12	6	18	731.38
#141	STAT5B	12	11	23	850.587
#142	GCM1	12	10	22	2179.053
#143	CLOCK	12	12	24	1881.857
#144	RARB	12	7	19	965.047
#145	HIRA	12	14	26	2531.055
#146	SIX5	12	9	21	358.311
#147	FOXA2	11	10	21	1299.99
#148	HHEX	11	10	21	771.259
#149	NR1H3	11	9	20	1375.365
#150	SNAPC4	11	13	24	1945.427
#151	FEV	11	12	23	1888.748
#152	ZSCAN23	11	9	20	725.305
#153	SIX4	11	12	23	2158.826
#154	MITF	11	10	21	1911.803
#155	REST	11	11	22	1580.119
#156	TFAP2B	11	11	22	1157.416
#157	HNRNPAB	11	11	22	1463.275
#158	JUND	11	9	20	1548.967
#159	ZEB2	11	8	19	1520.114
#160	SOX1	11	4	15	904.58
#161	AFF4	11	9	20	1521.695
#162	HOXC8	11	5	16	723.735
#163	MYBL2	11	10	21	4511.909
#164	LHX6	11	14	25	1514.742
#165	TFDP1	11	10	21	1291.803
#166	ZNF157	11	8	19	1092.766
#167	ANKRD30A	11	8	19	1098.506
#168	C2orf3	11	11	22	1261.376
#169	TAL1	11	10	21	600.705
#170	MYC	11	9	20	1509.544
#171	ZFPM2	11	10	21	1954.573
#172	ZNF92	11	7	18	1188.576
#173	ZNF33B	11	8	19	1421.811
#174	ASCL2	11	12	23	3277.295
#175	TAF5	11	13	24	1446.75
#176	GATAD1	11	11	22	2230.83
#177	GATA2	11	12	23	1355.624
#178	EPAS1	11	9	20	916.092
#179	ZNF174	11	11	22	1266.594
#180	NR6A1	11	10	21	1168.992
#181	ATF7	11	9	20	1402.036
#182	RUNX2	11	6	17	710.815
#183	SIX2	10	11	21	1418.417
#184	ZNF81	10	11	21	2005.211
#185	ZNF496	10	11	21	3117.186
#186	BLZF1	10	8	18	1295.727
#187	PPARD	10	11	21	1355.549
#188	RFX3	10	8	18	1156.772
#189	FOXO4	10	12	22	2053.586
#190	LHX8	10	12	22	1164.754
#191	ST18	10	12	22	908.586
#192	NR2F1	10	11	21	971.936
#193	NCOR1	10	5	15	511.463
#194	SUPT4H1	10	10	20	1707.589
#195	ZNF132	10	9	19	1231.86
#196	ZBTB17	10	6	16	652.665
#197	ZNF277	10	9	19	1178.805
#198	ARNT	10	9	19	686.915
#199	SOX21	10	9	19	801.178
#200	FOXP2	10	14	24	2416.128
#201	MESP2	10	9	19	654.536
#202	ZNF85	10	11	21	1409.516
#203	POU2F1	10	9	19	376.737
#204	ZNF193	10	9	19	1680.127
#205	ZNF24	10	13	23	2061.743
#206	MYNN	10	12	22	1104.92
#207	GATA5	10	11	21	1355.771
#208	GTF2H2	10	12	22	1080.292
#209	TADA2A	10	10	20	1408.214
#210	SATB2	10	9	19	515.45
#211	ESR1	10	9	19	1091.477
#212	RXRG	10	12	22	1906.432
#213	ARX	10	9	19	484.736
#214	ZNF449	10	11	21	2307.86
#215	KLF9	10	11	21	1235.817
#216	TBX1	10	8	18	936.121
#217	ZNF75D	10	10	20	412.182
#218	TSHZ2	10	9	19	1011.105
#219	ZNF3	10	13	23	1248.237
#220	TBX20	10	16	26	1972.973
#221	KLF2	10	12	22	678.533
#222	NFIA	10	10	20	1036.301
#223	BATF	10	11	21	557.606
#224	LHX1	9	9	18	1568.065
#225	LHX9	9	15	24	1432.025
#226	SOX18	9	10	19	1055.173
#227	FOXA1	9	12	21	3320.082
#228	ZSCAN4	9	10	19	957.575
#229	IKZF1	9	14	23	1132.543
#230	MLLT10	9	10	19	1319.49
#231	NPAS1	9	15	24	1761.63
#232	HIF3A	9	10	19	1339.507
#233	SOX6	9	11	20	1344.607
#234	SIX3	9	12	21	1490.254
#235	PHTF1	9	8	17	542.403
#236	TCF21	9	8	17	830.53
#237	VSX1	9	8	17	703.962
#238	NFE2	9	8	17	1064.762
#239	SLC2A4RG	9	14	23	1070.436
#240	LASS5	9	10	19	1836.154
#241	ZIC3	9	14	23	1475.181
#242	HMG20B	9	11	20	1579.714
#243	DMBX1	9	8	17	728.887
#244	SPIB	9	12	21	1053.067
#245	CREB3L3	9	12	21	1289.459
#246	MLXIPL	9	8	17	443.153
#247	WT1	9	8	17	982.547
#248	TCF4	9	11	20	1290.261
#249	TAF1B	9	8	17	1376.472
#250	L3MBTL4	9	12	21	1432.864
#251	FOXD3	9	6	15	984.849
#252	NKX2-8	9	10	19	1297.457
#253	ZNF444	9	13	22	1948.128
#254	NFYC	9	8	17	713.295
#255	FOXS1	9	10	19	1482.304
#256	HES6	9	9	18	1302.1
#257	NKX3-2	9	9	18	874.427
#258	RUNX3	9	12	21	1035.189
#259	ATF3	9	10	19	713.071
#260	PRRX1	9	7	16	202.305
#261	FOXK1	9	9	18	1077.168
#262	ONECUT1	9	11	20	1356.307
#263	GATA6	9	8	17	1400.28
#264	PPBPL2	9	6	15	729.02
#265	EMX1	9	12	21	1648.155
#266	NKX2-3	9	8	17	757.628
#267	PBX4	9	12	21	1163.923
#268	POU3F2	8	8	16	537.42
#269	TBX22	8	13	21	1913.029
#270	HOXA13	8	10	18	674.413
#271	EHF	8	10	18	649.419
#272	IKZF4	8	8	16	526.092
#273	NFATC4	8	12	20	2825.989
#274	ZNF446	8	8	16	799.969
#275	STRN3	8	11	19	1155.413
#276	ASCL1	8	11	19	1549.919
#277	SOX13	8	10	18	748.403
#278	PPARA	8	11	19	1405.167
#279	FOXE1	8	8	16	684.015
#280	DLX6	8	9	17	639.137
#281	MAX	8	11	19	1020.029
#282	NKX2-5	8	6	14	378.212
#283	T	8	8	16	995.148
#284	GABPA	8	10	18	976.744
#285	FOXE3	8	6	14	729.13
#286	ZNF207	8	12	20	1110.958
#287	ZNF154	8	7	15	770.166
#288	HOXD1	8	10	18	886.876
#289	PHOX2A	8	8	16	2065.733
#290	PITX1	8	13	21	744.651
#291	SOX2	8	14	22	1581.124
#292	TAF12	8	7	15	638.745
#293	SALL1	8	14	22	1795.896
#294	HOXC12	8	11	19	1176.504
#295	PKNOX2	8	10	18	1599.283
#296	MESP1	8	7	15	392.451
#297	MYCN	8	11	19	993.308
#298	ZNF41	8	13	21	1637.419
#299	TP73	8	14	22	1882.318
#300	POU4F1	8	12	20	1080.866
#301	ATF6B	8	6	14	858.953
#302	ELK4	8	15	23	1654.428
#303	PITX2	8	14	22	987.802
#304	TCF3	8	7	15	572.236
#305	ZNF434	8	12	20	1065.094
#306	GLI2	8	9	17	1538.521
#307	SMAD4	8	11	19	1118.541
#308	ESRRB	8	5	13	632.053
#309	ZNF238	8	12	20	1332.994
#310	ERG	8	10	18	1124.274
#311	NFATC2	8	13	21	1681.706
#312	TBX2	8	11	19	1293.25
#313	IRF1	8	11	19	876.596
#314	PAX8	8	9	17	1347.327
#315	ZSCAN12	7	13	20	1215.671
#316	NR3C2	7	10	17	494.605
#317	NR4A3	7	10	17	757.909
#318	SIN3A	7	12	19	1276.843
#319	BRD8	7	8	15	775.588
#320	ZNF90	7	12	19	1352.718
#321	YY1	7	9	16	1253.877
#322	TRERF1	7	12	19	1173.606
#323	RARG	7	11	18	905.661
#324	SMAD3	7	9	16	931.84
#325	HNF4A	7	9	16	992.307
#326	NR1H4	7	10	17	884.457
#327	CTBP1	7	6	13	570.137
#328	MYF5	7	8	15	781.015
#329	ALX3	7	9	16	588.35
#330	FOXM1	7	8	15	619.005
#331	SNAI3	7	11	18	982.52
#332	DLX1	7	10	17	1022.222
#333	RCOR1	7	9	16	616.208
#334	KLF15	7	8	15	796.557
#335	MEIS1	7	12	19	1072.098
#336	BCL11B	7	10	17	756.183
#337	TEF	7	12	19	699.041
#338	ZFP42	7	8	15	865.546
#339	SP1	7	11	18	1066.888
#340	GLI3	7	6	13	477.034
#341	FOXG1	7	9	16	788.145
#342	NEUROG1	7	9	16	890.082
#343	DMRT1	7	10	17	663.966
#344	TSC22D2	7	13	20	419.916
#345	SIM2	7	9	16	1007.817
#346	NRL	7	15	22	1491.139
#347	GATA4	7	13	20	1594.909
#348	ZIC1	7	11	18	643.271
#349	RORB	7	14	21	1276.032
#350	MGA	7	15	22	1715.817
#351	PEG3	7	11	18	805.29
#352	MYT1L	7	12	19	1408.463
#353	C11orf9	7	9	16	765.541
#354	FLI1	7	11	18	893.56
#355	SIM1	7	19	26	2092.749
#356	PAX6	7	14	21	1480.149
#357	FOXP1	7	8	15	636.174
#358	TSC22D3	7	10	17	766.698
#359	SIX6	7	7	14	839.249
#360	ZXDC	7	12	19	1060.945
#361	NEUROD2	7	14	21	1429.992
#362	HCFC1	7	10	17	832.014
#363	HOXD4	7	13	20	1345.425
#364	FOXK2	7	10	17	1497.383
#365	PAX3	6	13	19	749.96
#366	SPDEF	6	10	16	296.643
#367	EBF1	6	10	16	677.644
#368	MKX	6	12	18	843.589
#369	CREBBP	6	12	18	769.024
#370	HOXD11	6	13	19	835.555
#371	MTA2	6	10	16	587.909
#372	HDX	6	5	11	327.615
#373	RUNX1T1	6	12	18	927.893
#374	ZBTB38	6	11	17	1500.852
#375	ARID4A	6	14	20	608.839
#376	HOXB6	6	13	19	488.299
#377	ZNF202	6	15	21	1447.487
#378	SP3	6	10	16	889.283
#379	FOXO1	6	11	17	758.789
#380	ZGLP1	6	9	15	763.436
#381	FOXL2	6	10	16	558.971
#382	KDM5B	6	9	15	571.695
#383	HLF	6	11	17	856.939
#384	HOXB7	6	16	22	1522.136
#385	POU2F3	6	9	15	411.804
#386	GSX1	6	13	19	1063.318
#387	IRF8	6	7	13	489.456
#388	HSF5	6	11	17	790.558
#389	CREM	6	10	16	1211.024
#390	SCAND2	6	7	13	994.84
#391	PGR	6	12	18	936.221
#392	NFATC1	6	9	15	731.08
#393	ZNF175	6	12	18	963.402
#394	ATOH1	6	11	17	793.554
#395	NPAT	6	14	20	1825.756
#396	TLX3	6	13	19	988.417
#397	RORA	6	12	18	1044.367
#398	TLX2	6	11	17	854.755
#399	IRF4	6	13	19	1221.039
#400	EVX1	6	12	18	1069.241
#401	MSX2	6	11	17	743.964
#402	POU6F1	6	8	14	655.53
#403	C12orf28	6	10	16	755.102
#404	IKZF3	6	12	18	952.926
#405	SOX30	6	10	16	968.553
#406	ZNF215	6	9	15	842.283
#407	DMRT2	6	15	21	1061.646
#408	RFXAP	6	8	14	479.719
#409	NANOG	6	11	17	687.709
#410	TFEC	6	14	20	1249.685
#411	ZNF500	6	15	21	1239.677
#412	FOXL1	6	9	15	650.699
#413	TFAP4	6	10	16	616.617
#414	MLL	6	13	19	793.449
#415	HOXA4	6	10	16	640.802
#416	ELK1	6	7	13	529.467
#417	MYT1	6	10	16	980.283
#418	ETV1	6	13	19	1470.395
#419	PHOX2B	6	8	14	543.258
#420	POU6F2	6	14	20	1043.978
#421	ZNF169	6	11	17	1110.791
#422	OVOL1	6	11	17	1860.422
#423	HOXA2	5	13	18	757.706
#424	ZNF93	5	13	18	772.027
#425	SLC26A3	5	12	17	1765.909
#426	ZNF131	5	14	19	1204.288
#427	BHLHE41	5	13	18	877.09
#428	ISL1	5	9	14	617.102
#429	MEOX2	5	16	21	983.46
#430	VTN	5	12	17	958.716
#431	ZFP36L1	5	9	14	805.191
#432	ZFHX4	5	10	15	765.96
#433	HSF2	5	8	13	546.683
#434	PURB	5	11	16	734.62
#435	NR1I3	5	10	15	522.795
#436	ETV2	5	8	13	468.252
#437	POU3F4	5	11	16	755.897
#438	NR5A2	5	11	16	866.956
#439	ZNF397	5	17	22	1060.361
#440	NR2C1	5	10	15	917.101
#441	ZSCAN20	5	11	16	979.623
#442	LHX2	5	12	17	740.856
#443	TFDP2	5	13	18	491.688
#444	FOXO3	5	7	12	506.999
#445	AR	5	10	15	509.875
#446	FOXN4	5	11	16	746.63
#447	HES5	5	10	15	464.133
#448	LMX1A	5	15	20	1718.098
#449	TFAP2D	5	10	15	752.603
#450	ATF5	5	8	13	1035.801
#451	BARX1	5	6	11	468.024
#452	ZNF148	5	10	15	727.394
#453	ONECUT2	5	11	16	485.334
#454	NFYA	5	9	14	648.295
#455	PBX3	4	11	15	1203.233
#456	KLF12	4	14	18	900.349
#457	ZNF197	4	11	15	427.117
#458	HMGA2	4	9	13	653.919
#459	EN2	4	14	18	604.834
#460	SP4	4	10	14	295.432
#461	HOXD9	4	13	17	462.188
#462	HNF1A	4	9	13	295.439
#463	OLIG2	4	14	18	601.156
#464	NFKB2	4	10	14	333.876
#465	ZNF117	4	10	14	668.678
#466	ZNF287	4	13	17	617.422
#467	PLSCR1	4	13	17	1065.292
#468	HOXC5	4	8	12	411.421
#469	CREBZF	4	11	15	894.197
#470	SP140	4	14	18	906.7
#471	GATAD2B	4	10	14	650.168
#472	ZNF19	4	12	16	948.923
#473	ZNF483	4	15	19	1100.708
#474	ZNF71	4	11	15	975.168
#475	DLX3	4	13	17	475.224
#476	NR5A1	4	8	12	574.677
#477	BACH1	4	12	16	609.416
#478	PTH	4	8	12	773.756
#479	HOXD13	4	14	18	771.098
#480	SMAD2	4	7	11	693.623
#481	GAS7	3	14	17	587.285
#482	ZNF639	3	18	21	513.795
#483	ATF2	3	16	19	330.853
#484	FOXA3	3	8	11	367.262
#485	SIX1	3	10	13	448.439
#486	ZIC5	3	15	18	647.647
#487	ESRRG	3	6	9	430.906
#488	HNF4G	3	14	17	3332.573
#489	POU3F3	3	12	15	416.066
#490	ZFHX3	3	10	13	364.981
#491	MYCL1	3	11	14	497.963
#492	ALS2CR8	3	12	15	539.311
#493	SRY	3	13	16	456.065
#494	RXRB	3	7	10	226.817
#495	HOXD3	3	16	19	1631.496
#496	LMX1B	2	19	21	557.233
#497	ZNF396	2	12	14	262.69
#498	NFYB	2	14	16	394.939
#499	MEF2C	1	15	16	248.829
#500	ZEB1	0	12	12	0