Hub Rank	Node	Children	Parents	Degree	Betweenness
#1	HOXA11	72	1	73	404.337
#2	SMAD4	48	3	51	142.513
#3	MAX	47	2	49	451.092
#4	CNOT8	46	9	55	1049.057
#5	ISL1	44	6	50	550.624
#6	FOXA1	43	4	47	3627.041
#7	STAT2	42	5	47	603.357
#8	MAF	42	9	51	1815.854
#9	IKZF1	40	10	50	1030.533
#10	ZNF148	39	1	40	65.151
#11	NFATC3	38	8	46	1750.32
#12	GATA3	37	3	40	315.955
#13	T	37	9	46	1137.216
#14	NKX2-1	37	8	45	2125.222
#15	FOXC1	36	8	44	945.645
#16	FOS	35	3	38	951.349
#17	TCEAL1	35	3	38	750.205
#18	SPIB	35	9	44	878.606
#19	SP140	34	6	40	1222.783
#20	XBP1	34	1	35	24.23
#21	E2F4	34	13	47	3119.209
#22	HCLS1	34	1	35	76.402
#23	ZBTB48	33	9	42	1467.451
#24	NFE2L2	33	9	42	723.05
#25	TFDP1	33	9	42	921.728
#26	JUNB	33	3	36	255.943
#27	BHLHE40	32	5	37	679.35
#28	NR2F6	32	10	42	1399.652
#29	RUNX3	32	11	43	966.878
#30	STAT1	32	5	37	693.724
#31	EGR3	32	7	39	886.678
#32	TAF4	31	12	43	1161.052
#33	RXRA	31	12	43	1352.523
#34	SIX6	31	14	45	2850.662
#35	FOXM1	31	4	35	258.843
#36	ZEB1	30	3	33	210.862
#37	HNF1B	30	7	37	560.039
#38	RELA	30	11	41	783.462
#39	NFIB	30	14	44	1122.618
#40	MYBL2	29	7	36	731.691
#41	NR1H2	29	7	36	3123.991
#42	NR2E3	29	6	35	753.135
#43	SOLH	28	12	40	1442.715
#44	IRX5	28	10	38	948.432
#45	BTG2	28	6	34	485.646
#46	RCOR1	28	12	40	1013.48
#47	TSC22D3	28	15	43	2017.761
#48	NFIL3	27	12	39	1678.476
#49	TCF3	27	13	40	2535.339
#50	TSC22D2	27	13	40	2690.117
#51	NR1D2	27	6	33	1407.406
#52	FLI1	27	7	34	1657.246
#53	CTNNB1	27	10	37	970.133
#54	HDAC1	27	4	31	554.528
#55	SALL2	26	7	33	489.742
#56	CREB1	26	4	30	1356.643
#57	MEIS2	26	14	40	2378.973
#58	CREB3L2	26	8	34	1322.125
#59	POU2F3	26	13	39	2197.61
#60	ZNF3	26	9	35	1424.236
#61	SMAD2	26	7	33	1927.337
#62	FOXC2	25	6	31	322.838
#63	TLX2	25	12	37	1039.384
#64	JUN	25	5	30	640.913
#65	MAFF	25	11	36	845.89
#66	STAT6	25	5	30	862.712
#67	BRD8	25	16	41	1838.285
#68	PRRX1	25	14	39	561.209
#69	ZNF189	24	15	39	2867.003
#70	LMO4	24	9	33	698.611
#71	CREBZF	24	14	38	1770.89
#72	HMX1	24	8	32	945.551
#73	CEBPB	24	10	34	1744.661
#74	TCF7	24	7	31	446.823
#75	SP3	24	10	34	307.102
#76	RARA	23	12	35	1237.626
#77	E2F3	23	11	34	933.696
#78	AR	23	10	33	1403.11
#79	HDAC2	23	9	32	1488.338
#80	YBX1	23	7	30	1053.443
#81	HOXB7	23	15	38	1505.499
#82	CREBL2	23	16	39	2957.696
#83	IRF1	23	2	25	48.507
#84	HIF1A	23	7	30	1206.196
#85	AHCTF1	23	8	31	1351.326
#86	TCF15	23	11	34	874.644
#87	KLF10	22	12	34	958.019
#88	ZNF263	22	13	35	1236.773
#89	FOSB	22	1	23	10.371
#90	ELK1	22	12	34	827.699
#91	POU6F1	22	19	41	2287.556
#92	RCAN1	22	14	36	1871.469
#93	SOX10	22	11	33	1471.035
#94	ZKSCAN1	21	11	32	619.229
#95	TRIM22	21	12	33	1813.02
#96	TWIST1	21	12	33	1976.255
#97	ZEB2	21	13	34	2644.604
#98	ETS2	21	14	35	1384.644
#99	IRF8	21	6	27	699.643
#100	SMAD5	21	15	36	2226.998
#101	MEOX2	21	9	30	1524.511
#102	TRIM29	21	5	26	178.126
#103	HR	20	11	31	679.438
#104	NR3C2	20	17	37	2138.684
#105	SNAPC4	20	18	38	2307.74
#106	ERF	20	12	32	1598.315
#107	PHOX2B	20	18	38	2267.159
#108	PPARD	20	13	33	776.034
#109	CSDA	20	12	32	1145.993
#110	NR4A1	20	7	27	230.723
#111	EGR2	20	13	33	1746.732
#112	PBX3	20	13	33	1947.662
#113	MSX1	20	10	30	519.338
#114	ATF7	20	16	36	1839.233
#115	PTTG1	20	10	30	706.899
#116	ZNF167	20	8	28	894.914
#117	GAS7	19	10	29	335.097
#118	POU3F2	19	12	31	614.552
#119	ELF1	19	11	30	2278.31
#120	NR4A2	19	17	36	1702.23
#121	SMAD9	19	13	32	1126.306
#122	FEV	19	20	39	1882.756
#123	FOXA2	19	11	30	2569.663
#124	YY1	19	12	31	1097.966
#125	SUPT6H	19	15	34	2336.717
#126	PBX1	19	3	22	600.652
#127	ZNF75D	19	11	30	1756.358
#128	TBX5	19	19	38	2197.713
#129	RARB	18	20	38	1431.225
#130	SNAPC2	18	14	32	1571.624
#131	TCF21	18	16	34	1622.918
#132	SOX9	18	16	34	1407.047
#133	WNT5A	18	13	31	784.01
#134	SMAD1	18	11	29	1007.857
#135	MMP14	18	9	27	456.478
#136	VAV1	18	7	25	626.724
#137	NR3C1	18	13	31	1164.621
#138	NR2F1	18	14	32	1176.956
#139	GTF2H4	18	14	32	1775.022
#140	STAT5A	18	13	31	850.894
#141	HOXD10	18	22	40	1998.782
#142	EGR1	18	8	26	585.933
#143	PPARA	18	17	35	2190.94
#144	HNF1A	17	16	33	871.422
#145	HMGA1	17	15	32	2338.321
#146	NR1H3	17	12	29	894.945
#147	GATAD1	17	17	34	1421.941
#148	CUX1	17	13	30	1605.267
#149	HES1	17	21	38	2782.574
#150	ELK3	17	9	26	1274.151
#151	STAT4	17	6	23	224.38
#152	TP63	17	8	25	311.156
#153	MYT1	17	18	35	1662.871
#154	MYC	17	12	29	959.215
#155	NFKB1	17	12	29	430.568
#156	PPBPL2	17	15	32	1088.418
#157	ATF3	17	10	27	756.178
#158	HIRA	17	14	31	2435.035
#159	PAX6	16	14	30	1078.811
#160	NR5A1	16	14	30	1141.741
#161	ZNF268	16	18	34	2069.966
#162	IRF2	16	9	25	723.439
#163	THRB	16	19	35	2383.91
#164	ALX1	16	15	31	2633.964
#165	LASS6	16	8	24	249.385
#166	SPI1	16	11	27	602.842
#167	ZNF24	16	13	29	1057.19
#168	PAX3	16	14	30	1657.478
#169	RFXANK	16	12	28	1031.58
#170	PLSCR1	16	12	28	1119.762
#171	TEAD4	16	8	24	817.177
#172	CITED2	16	10	26	826.837
#173	GATA1	16	12	28	1576.549
#174	PAX5	16	14	30	1424.419
#175	ELF3	16	7	23	409.581
#176	MYOD1	16	16	32	1449.548
#177	MAFK	15	11	26	634.186
#178	ZNF81	15	19	34	1364.767
#179	MEIS1	15	15	30	785.865
#180	NR2C1	15	16	31	1422.208
#181	SATB1	15	16	31	719.335
#182	ZFP36L2	15	7	22	508.508
#183	TEF	15	21	36	2510.198
#184	ZNF217	15	8	23	346.589
#185	TAF12	15	17	32	1769.959
#186	POU2F2	15	16	31	873.236
#187	ETV5	15	16	31	1017.464
#188	TFEB	15	14	29	749.005
#189	MXD1	15	14	29	1542.452
#190	HMGB2	15	13	28	739.639
#191	HHEX	15	12	27	901.159
#192	AHR	15	13	28	1496.99
#193	KLF6	15	12	27	821.79
#194	TSC22D1	15	18	33	1043.263
#195	FOXN3	14	12	26	607.221
#196	HOXD8	14	22	36	876.171
#197	ZNF238	14	20	34	2238.044
#198	TRIM25	14	13	27	757.12
#199	TP53	14	15	29	2102.256
#200	RXRG	14	19	33	1877.084
#201	KLF9	14	12	26	642.119
#202	MEIS3P1	14	12	26	1070.332
#203	IRF4	14	12	26	184.713
#204	ZNF140	14	17	31	1354.356
#205	MYCL1	14	19	33	1022.77
#206	RARG	14	18	32	1364.175
#207	IRX3	14	11	25	414.296
#208	KLF7	14	9	23	517.568
#209	ZNF91	14	11	25	1281.226
#210	MEOX1	14	14	28	614.615
#211	MEF2C	14	18	32	1207.505
#212	SUPT4H1	14	11	25	1577.103
#213	FOXO4	14	21	35	1587.1
#214	PURA	14	12	26	1271.448
#215	HOXB2	14	12	26	1229.228
#216	TCFL5	14	12	26	936.991
#217	SLC26A3	14	19	33	1369.571
#218	IRF9	13	9	22	718.232
#219	NFE2L3	13	14	27	2587.999
#220	SOX15	13	18	31	1221.296
#221	HOXA10	13	17	30	1719.353
#222	HOXA4	13	15	28	1463.525
#223	RB1	13	17	30	705.831
#224	NFAT5	13	10	23	457.641
#225	ONECUT2	13	11	24	989.799
#226	E2F5	13	20	33	903.527
#227	CBL	13	17	30	876.867
#228	PAX8	13	16	29	1549.989
#229	HOXC11	13	16	29	735.253
#230	KLF5	13	18	31	1645.511
#231	ZFP37	13	15	28	1345.605
#232	ZNF117	13	14	27	658.544
#233	BATF	13	17	30	1205.853
#234	EN2	13	18	31	1543.712
#235	ZNF35	13	15	28	1196.822
#236	SNAI2	13	28	41	3116.74
#237	HOXA5	13	14	27	1134.289
#238	STAT3	13	12	25	440.3
#239	ZHX3	13	14	27	938.993
#240	NPAS2	13	23	36	1386.891
#241	RFX1	13	13	26	511.423
#242	ONECUT1	12	15	27	1883.758
#243	KDM5B	12	14	26	626.199
#244	CITED1	12	10	22	311.616
#245	POU3F4	12	14	26	628.317
#246	PTH	12	15	27	1610.362
#247	HOXB5	12	6	18	306.023
#248	HOXD3	12	15	27	1104.654
#249	GATA4	12	16	28	1055.793
#250	BNC1	12	7	19	546.853
#251	LZTR1	12	14	26	1749.27
#252	ZNF197	12	22	34	1311.365
#253	CBFA2T3	12	21	33	902.377
#254	MBD1	12	11	23	1043.33
#255	ELF4	12	17	29	729.63
#256	ATF6	12	15	27	820.216
#257	FOXD1	12	12	24	747.184
#258	ASCL2	12	14	26	948.055
#259	NFATC4	12	15	27	628.485
#260	MYOG	12	18	30	1050.648
#261	HOXB3	12	11	23	477.431
#262	VDR	12	19	31	1228.133
#263	SMAD3	12	19	31	817.04
#264	GABPB1	11	17	28	1161.508
#265	TFAP2A	11	21	32	1261.313
#266	JUND	11	16	27	931.151
#267	HSF2	11	12	23	569.928
#268	ZIC3	11	16	27	954.574
#269	POU6F2	11	14	25	455.411
#270	PCGF2	11	21	32	1640.747
#271	NKX2-5	11	12	23	855.325
#272	ZNF169	11	18	29	1217.587
#273	DBP	11	14	25	1328.553
#274	IRF6	11	16	27	414.71
#275	FOXO3	11	11	22	850.797
#276	NR0B1	11	15	26	345.281
#277	E2F6	11	14	25	701.276
#278	NKX3-2	11	18	29	809.558
#279	CDX2	11	13	24	950.455
#280	ELK4	11	18	29	856.977
#281	AEBP1	11	18	29	743.807
#282	ESR1	11	12	23	624.62
#283	ZNF37A	11	12	23	1134.916
#284	PBX2	11	24	35	1221.34
#285	ZNF33B	11	14	25	1150.28
#286	ZNF175	11	18	29	1670.675
#287	ZKSCAN4	11	16	27	1187.502
#288	HOXA9	11	11	22	1379.509
#289	MTA1	10	20	30	1611.044
#290	GATA2	10	15	25	989.192
#291	NKX2-8	10	16	26	711.238
#292	MNX1	10	17	27	882.547
#293	NR6A1	10	12	22	994.97
#294	GABPA	10	15	25	2265.939
#295	CDKN2A	10	17	27	1590.919
#296	MSX2	10	20	30	754.113
#297	WT1	10	17	27	741.276
#298	E2F1	10	13	23	1279.488
#299	ZKSCAN5	10	18	28	1019.446
#300	RFX3	10	13	23	891.065
#301	LMX1B	10	14	24	523.887
#302	LEF1	10	12	22	438.492
#303	PRDM2	10	18	28	2131.708
#304	DDIT3	10	13	23	690.416
#305	ERG	10	7	17	611.603
#306	ZNF132	10	19	29	1705.862
#307	ZNF643	10	13	23	957.076
#308	SCML2	10	14	24	650.859
#309	ESRRB	10	14	24	1026.245
#310	NFATC1	10	16	26	1012.646
#311	FOXI1	10	16	26	1649.245
#312	TCF7L2	10	23	33	1111.831
#313	KLF1	10	16	26	843.514
#314	SOX12	10	18	28	1656.189
#315	HINFP	10	15	25	563.886
#316	ASCL1	10	19	29	1210.69
#317	HOXD4	10	13	23	1117.492
#318	THRA	10	13	23	956.418
#319	GBX2	9	16	25	511.298
#320	SOX4	9	18	27	762.1
#321	FOXJ1	9	19	28	855.625
#322	TGIF2	9	18	27	633.497
#323	MLLT10	9	19	28	1152.776
#324	ATF2	9	18	27	2030.77
#325	PKNOX1	9	17	26	984.373
#326	SP1	9	16	25	1128.05
#327	HMGA2	9	18	27	1124.865
#328	TCF20	9	19	28	864.413
#329	PITX1	9	18	27	689.51
#330	SREBF1	9	16	25	552.673
#331	SOX21	9	11	20	1126.234
#332	GLI3	9	12	21	254.909
#333	TAF5	9	14	23	1582.606
#334	FOXF1	9	12	21	497.507
#335	RUNX1	9	18	27	229.96
#336	ZNF80	9	14	23	1029.667
#337	ZNF192	9	20	29	983.091
#338	CREB3L1	9	23	32	1404.239
#339	NRL	9	16	25	920.781
#340	NR4A3	9	18	27	584.367
#341	CTBP1	9	17	26	987.664
#342	ETV6	9	16	25	659.001
#343	CEBPD	9	14	23	541.163
#344	ESRRG	9	24	33	762.296
#345	SALL1	9	21	30	1074.053
#346	HOXA1	9	20	29	975.8
#347	KLF4	9	18	27	860.508
#348	FOXF2	9	18	27	1250.674
#349	TFCP2	8	13	21	434.092
#350	NFKB2	8	13	21	246.092
#351	TBX2	8	22	30	1379.172
#352	POU4F2	8	14	22	818.211
#353	STAT5B	8	16	24	593.071
#354	ZNF274	8	22	30	1104.607
#355	AFF1	8	17	25	1185.022
#356	GCM1	8	15	23	549.002
#357	ZNF45	8	14	22	790.234
#358	NKX3-1	8	16	24	815.172
#359	TFAP2B	8	24	32	783.944
#360	GATA6	8	21	29	1204.907
#361	HOXD1	8	15	23	932.497
#362	KDM5A	8	13	21	1165.56
#363	HOXB6	8	5	13	511.879
#364	ELF5	8	12	20	288.286
#365	HOPX	8	18	26	1245.192
#366	PHTF1	8	17	25	1527.833
#367	SIM2	8	14	22	651.14
#368	NPAS1	8	14	22	585.178
#369	ZSCAN12	8	15	23	1283.309
#370	ADNP2	8	19	27	899.509
#371	DLX2	8	23	31	929.842
#372	ZIC1	8	21	29	668.743
#373	NR1H4	8	23	31	1815.135
#374	HOXB13	8	21	29	623.299
#375	KLF11	8	17	25	1621.479
#376	TFEC	7	18	25	632.746
#377	LHX2	7	18	25	657.623
#378	TBX10	7	16	23	630.139
#379	RUNX2	7	18	25	759.482
#380	ZNF154	7	20	27	1083.137
#381	EGR4	7	13	20	905.246
#382	HOXB1	7	17	24	465.2
#383	NFIX	7	19	26	808.873
#384	ETV4	7	21	28	1784.8
#385	VTN	7	23	30	2085.171
#386	CRX	7	20	27	671.815
#387	MITF	7	12	19	436.22
#388	REL	7	16	23	570.345
#389	TAF4B	7	12	19	382.498
#390	SOX11	7	20	27	591.365
#391	EMX1	7	18	25	596.046
#392	RORB	7	12	19	783.707
#393	FOXK2	7	15	22	297.575
#394	SIX3	7	15	22	770.351
#395	BLZF1	7	24	31	721.923
#396	ARNT2	7	10	17	125.151
#397	EPAS1	7	16	23	521.392
#398	TFAM	7	15	22	810.886
#399	PITX2	7	17	24	979.848
#400	SOX5	7	16	23	712.554
#401	TAL1	7	21	28	1525.437
#402	POU1F1	7	26	33	1419.843
#403	MYF6	7	14	21	452.862
#404	REST	7	17	24	527.933
#405	SCAND2	7	18	25	1049.266
#406	TBR1	7	14	21	558.991
#407	NR2F2	7	17	24	374.189
#408	TCF4	7	16	23	668.152
#409	ZIC2	7	15	22	890.838
#410	E2F2	7	18	25	530.769
#411	IRF5	6	9	15	285.688
#412	ARID4A	6	22	28	939.02
#413	TADA2A	6	18	24	973.527
#414	TEAD1	6	18	24	1119.693
#415	TFAP2C	6	14	20	512.494
#416	ETV3	6	16	22	416.651
#417	NR1I2	6	18	24	390.616
#418	PROX1	6	17	23	546.424
#419	ZNF92	6	19	25	564.004
#420	RUNX1T1	6	14	20	468.328
#421	IRF7	6	7	13	215.423
#422	SOX30	6	18	24	2141.043
#423	SPDEF	6	14	20	459.512
#424	PDX1	6	15	21	991.989
#425	TAF13	6	18	24	1014.075
#426	PPARG	6	17	23	554.949
#427	UBN1	6	11	17	972.052
#428	HLF	6	13	19	728.091
#429	NFIA	6	22	28	807.201
#430	HOXD9	6	11	17	507.435
#431	CEBPA	6	15	21	639.83
#432	ARNTL	6	19	25	682.619
#433	RORC	6	19	25	1176.406
#434	BTAF1	6	14	20	939.3
#435	POU4F1	6	16	22	670.86
#436	TFDP2	6	17	23	1194.621
#437	SMAD6	6	21	27	791.033
#438	ZNF165	5	22	27	552.211
#439	SHOX	5	17	22	516.16
#440	MYF5	5	20	25	1532.003
#441	PLAG1	5	18	23	662.564
#442	RFXAP	5	15	20	536.232
#443	MYCN	5	21	26	809.486
#444	TBX1	5	20	25	325.127
#445	ZBTB25	5	17	22	631.224
#446	NFIC	5	15	20	501.282
#447	ATF1	5	15	20	390.269
#448	PRDM1	5	15	20	306.729
#449	FOXN2	5	13	18	510.949
#450	ZNF41	5	14	19	407.9
#451	ATF6B	5	15	20	424.984
#452	FOXD2	5	22	27	723.434
#453	HNF4A	5	13	18	544.888
#454	GTF2H2	5	14	19	666.269
#455	SATB2	5	15	20	344.587
#456	HNF4G	5	23	28	1236.352
#457	OVOL1	4	15	19	537.402
#458	ST18	4	20	24	467.188
#459	GLI2	4	18	22	861.939
#460	PEG3	4	26	30	915.626
#461	PAX4	4	14	18	437.238
#462	ETV1	4	18	22	454.314
#463	NR5A2	4	19	23	983.618
#464	NR2E1	4	19	23	245.892
#465	PGR	4	22	26	334.284
#466	BCL6	4	21	25	270.259
#467	POU3F1	4	15	19	313.643
#468	LHX1	4	18	22	373.796
#469	SP4	4	19	23	442.648
#470	EVX1	4	14	18	232.491
#471	CREB5	4	19	23	507.764
#472	ETS1	4	16	20	357.609
#473	DLX4	4	14	18	352.07
#474	MYT1L	4	21	25	466.509
#475	FOXE1	4	18	22	512.753
#476	ZNF202	3	10	13	206.638
#477	NR2C2	3	19	22	870.374
#478	KLF12	3	21	24	408.085
#479	ZNF500	3	17	20	201.771
#480	C11orf9	3	21	24	220.726
#481	ESR2	3	22	25	470.46
#482	MECOM	3	17	20	589.946
#483	CUX2	3	22	25	276.84
#484	ZNF174	3	15	18	247.913
#485	NFE2	3	19	22	658.773
#486	NR1I3	2	17	19	175.702
#487	HESX1	2	15	17	164.399
#488	SOX2	2	18	20	542.407
#489	ETV2	2	16	18	369.243
#490	SIX1	2	20	22	218.118
#491	OLIG2	2	18	20	170.958
#492	RORA	2	14	16	338.94
#493	CLOCK	2	18	20	244.962
#494	ZNF135	2	27	29	217.984
#495	TAF1B	1	20	21	168.81
#496	FOXG1	1	14	15	61.221
#497	NEUROD1	1	16	17	183.359
#498	HOXA2	1	15	16	54.581
#499	HOXC4	1	25	26	210.787
#500	SIM1	0	18	18	0