Hub Rank	Node	Children	Parents	Degree	Betweenness
#1	LEF1	159	3	162	1065.112
#2	ZBTB38	135	3	138	106.703
#3	SNAI2	128	4	132	118.548
#4	TCF4	125	3	128	1453.12
#5	EPAS1	122	1	123	51.44
#6	FOXF2	121	5	126	1106.117
#7	BHLHE41	94	5	99	9166.082
#8	SOX9	76	5	81	89.177
#9	RUNX2	61	7	68	1347.408
#10	SMAD1	55	7	62	692.008
#11	RORA	52	10	62	4253.222
#12	MEIS1	51	9	60	3316.927
#13	HOXA10	49	6	55	360.601
#14	TCEAL1	48	7	55	227.648
#15	HOXB7	45	4	49	106.937
#16	TFAP2A	45	9	54	2479.535
#17	FOXD1	43	4	47	479.843
#18	KDM5B	43	9	52	2088.946
#19	FOXN3	43	8	51	730.405
#20	TEAD1	42	5	47	66.348
#21	FOXM1	42	4	46	69.437
#22	HOXA11	41	7	48	550.792
#23	TWIST2	38	7	45	728.931
#24	PRRX1	37	3	40	834.421
#25	SMAD9	37	11	48	1884.568
#26	WNT5A	36	8	44	875.635
#27	AEBP1	35	7	42	2170.25
#28	CREB3L1	31	4	35	133.486
#29	MEF2C	29	8	37	1019.071
#30	CEBPD	29	7	36	723.583
#31	TSC22D1	28	10	38	2178.06
#32	HOXA9	28	8	36	1409.392
#33	MITF	27	8	35	960.907
#34	KLF7	27	12	39	1129.137
#35	IRX3	27	11	38	1046.512
#36	ZFP90	26	9	35	1704.44
#37	KLF9	25	10	35	637.312
#38	TCFL5	25	4	29	1728.597
#39	FOSL1	25	11	36	1038.243
#40	ARNTL2	23	7	30	815.511
#41	C11orf9	23	9	32	1008.397
#42	ARNT2	23	10	33	485.941
#43	MECOM	23	10	33	276.153
#44	TRIM22	21	9	30	2456.544
#45	NR3C1	21	7	28	282.205
#46	EBF1	21	8	29	868.134
#47	VDR	21	11	32	339.965
#48	NFIX	21	8	29	223.3
#49	HDAC1	20	9	29	190.673
#50	ZHX2	19	7	26	322.265
#51	ZEB2	19	6	25	7242.021
#52	PBX1	19	9	28	1631.345
#53	MEIS3P1	19	8	27	667.492
#54	HMGA2	19	7	26	533.186
#55	SATB2	19	9	28	1169.982
#56	ZHX3	19	9	28	1152.214
#57	RUNX1	19	7	26	482.223
#58	MAFK	19	6	25	128.226
#59	MYBL2	18	6	24	358.082
#60	MEIS2	18	8	26	1009.435
#61	BATF3	17	6	23	248.231
#62	TEAD4	17	5	22	364.117
#63	HES6	16	8	24	881.702
#64	NR2F1	16	5	21	82.106
#65	GLIS2	16	3	19	56.056
#66	HOXB3	15	7	22	192.136
#67	CREB3L2	15	12	27	257.087
#68	NFYB	15	6	21	511.624
#69	RFX5	14	6	20	303.445
#70	HOXB2	14	9	23	656.281
#71	TSC22D3	14	5	19	86.84
#72	ZNF70	14	10	24	1039.047
#73	HMGB1	14	10	24	310.83
#74	HMG20B	14	6	20	605.154
#75	IRF8	14	7	21	184.15
#76	TFAM	14	8	22	635.27
#77	TFDP1	14	9	23	769.285
#78	GATA3	14	12	26	6554.704
#79	NFKB1	13	12	25	719.003
#80	HHEX	13	6	19	254.801
#81	MAFF	13	7	20	266.194
#82	FOXO3	13	7	20	244.637
#83	TFAP2C	13	11	24	7015.26
#84	PPARA	12	10	22	532.513
#85	TAF4B	12	10	22	314.094
#86	IRF4	12	5	17	131.685
#87	E2F8	12	15	27	1551.887
#88	FOXP1	12	10	22	659.533
#89	HOXD10	12	8	20	72.98
#90	HOXC10	11	9	20	1271.463
#91	GABPB1	11	7	18	87.08
#92	DLX1	11	4	15	127.435
#93	KLF4	11	2	13	16.995
#94	ZIC1	11	10	21	1523.885
#95	LASS6	11	4	15	47.951
#96	JDP2	11	6	17	288.132
#97	PURB	11	10	21	448.171
#98	TAF5L	10	9	19	416.93
#99	ZEB1	10	7	17	352.218
#100	ELK3	10	5	15	290.067
#101	GATA6	10	7	17	6635.213
#102	BCL6	10	12	22	863.683
#103	FOXO1	10	8	18	7690.902
#104	TFDP2	10	10	20	6895.976
#105	GLIS3	9	4	13	14.404
#106	FOXF1	9	7	16	96.315
#107	HOXA3	9	7	16	2397.436
#108	SALL2	9	9	18	978.586
#109	NFE2L3	9	9	18	217.96
#110	HOXA1	9	10	19	1092.723
#111	SNAPC5	9	7	16	259.052
#112	HSF1	9	11	20	204.345
#113	HMGB2	9	9	18	603.887
#114	NFIA	9	7	16	113.147
#115	ELF1	9	4	13	25.22
#116	AATF	9	6	15	601.425
#117	SCML1	9	10	19	229.924
#118	CUX1	9	9	18	131.185
#119	IRF9	9	6	15	66.087
#120	NFIB	9	9	18	91.841
#121	CREB3	9	10	19	101.725
#122	E2F5	8	9	17	1882.024
#123	HOXA5	8	6	14	35.257
#124	SOX13	8	8	16	357.73
#125	PLSCR1	8	7	15	277.981
#126	SOX6	8	7	15	813.343
#127	LHX8	8	4	12	348.029
#128	TGIF1	8	10	18	289.229
#129	ZNF92	8	8	16	65.435
#130	NFATC1	8	2	10	28.667
#131	TBX2	8	7	15	81.899
#132	TFEB	8	10	18	210.423
#133	ZFPM2	8	7	15	61.331
#134	TSHZ1	7	10	17	528.682
#135	C2orf3	7	7	14	32.486
#136	NR4A3	7	10	17	168.19
#137	ZNF323	7	8	15	2069.136
#138	DLX2	7	12	19	457.801
#139	EGR3	7	9	16	95.447
#140	STAT5B	7	6	13	380.576
#141	SATB1	7	8	15	77.691
#142	CITED2	7	8	15	277.389
#143	PA2G4	7	6	13	178.925
#144	AHR	7	7	14	85.233
#145	SP140	7	6	13	56.92
#146	TFE3	7	6	13	41.697
#147	GTF2H2	7	13	20	1500.497
#148	ATF5	7	11	18	174.279
#149	ZXDA	7	6	13	46.492
#150	PBX3	7	6	13	95.641
#151	MKX	7	7	14	291.9
#152	TRPS1	7	8	15	1110.209
#153	TFCP2	7	7	14	179.006
#154	FOXC1	7	8	15	349.478
#155	CREBZF	7	6	13	112.906
#156	REL	7	9	16	376.147
#157	CTNNB1	6	11	17	618.824
#158	CREBL2	6	7	13	416.712
#159	TWIST1	6	6	12	816.755
#160	SMAD6	6	5	11	170.252
#161	NFATC3	6	11	17	160.802
#162	TP53	6	8	14	996.706
#163	HOXB9	6	9	15	1673.458
#164	E2F2	6	5	11	156.264
#165	CSRNP1	6	10	16	1712.864
#166	MSC	6	8	14	128.172
#167	MTA3	6	9	15	447.696
#168	RB1	6	12	18	1593.325
#169	NKX3-1	6	4	10	24.414
#170	GLI3	6	7	13	342.952
#171	SIN3A	6	11	17	64.225
#172	PHTF1	6	10	16	223.969
#173	HOXC4	6	7	13	224.66
#174	C1orf85	6	8	14	110.184
#175	MAF	6	12	18	187.016
#176	VAV1	6	6	12	62.61
#177	MXD1	6	15	21	8621.458
#178	NR2C2	5	9	14	1664.212
#179	MBD1	5	11	16	342.616
#180	PRRX2	5	8	13	122.691
#181	ZRANB2	5	11	16	696.244
#182	HOXC9	5	7	12	384.726
#183	KLF5	5	5	10	72.223
#184	MSX1	5	11	16	1162.567
#185	CSDA	5	7	12	231.477
#186	SOX10	5	6	11	132.536
#187	PKNOX2	5	6	11	405.324
#188	GTF2IRD1	5	2	7	5.976
#189	ZNF33A	5	7	12	122.302
#190	KLF11	5	9	14	351.192
#191	FOSL2	5	10	15	1365.457
#192	FOXS1	5	12	17	631.996
#193	CBFB	5	17	22	1320.035
#194	AFF4	5	9	14	147.178
#195	KLF12	5	7	12	17.626
#196	ETV6	5	6	11	52.188
#197	SP4	5	10	15	83.067
#198	STAT2	5	9	14	951.975
#199	NR2F6	5	7	12	287.723
#200	ZNF232	4	5	9	13.178
#201	IKZF1	4	6	10	199.042
#202	RUNX3	4	5	9	554.005
#203	RUNX1T1	4	8	12	913.312
#204	PRDM1	4	10	14	80.241
#205	IRX2	4	6	10	72.73
#206	NFIL3	4	8	12	81.918
#207	SALL1	4	7	11	181.691
#208	ZSCAN18	4	9	13	56.617
#209	HOXB6	4	11	15	706.288
#210	PAX3	4	6	10	190.163
#211	NFKB2	4	9	13	1062.468
#212	MAFB	4	8	12	108.63
#213	C5orf41	4	12	16	620.314
#214	ONECUT2	4	8	12	54.17
#215	TCF7L1	4	9	13	444.18
#216	CITED1	4	3	7	3.466
#217	IRF5	4	10	14	328.462
#218	NR2F2	4	9	13	211.651
#219	CTBP1	4	7	11	1075.713
#220	WT1	4	7	11	33.48
#221	NOLC1	4	6	10	857.172
#222	NR4A1	4	8	12	81.028
#223	ZNF91	4	7	11	56.251
#224	ZFP36L2	4	9	13	45.049
#225	HOXA2	4	10	14	312.117
#226	PLAG1	4	9	13	372.599
#227	SMAD2	4	10	14	136.76
#228	SREBF1	4	8	12	8548.331
#229	CEBPB	4	5	9	86.787
#230	E2F4	4	9	13	64.627
#231	FOXA2	4	7	11	580.404
#232	HOXA13	3	7	10	233.435
#233	ZNF138	3	11	14	706.223
#234	ZNF33B	3	8	11	244.787
#235	PAX6	3	6	9	102.468
#236	PPARD	3	6	9	71.162
#237	SP1	3	10	13	8789.564
#238	NFYC	3	10	13	635.862
#239	GLI2	3	12	15	20.738
#240	DMRT2	3	7	10	236.398
#241	MLLT10	3	11	14	898.092
#242	PEG3	3	8	11	39.767
#243	HR	3	6	9	30.201
#244	ZFHX3	3	9	12	144.492
#245	HOXB13	3	11	14	129.88
#246	ZIC2	3	4	7	4983.304
#247	MEOX1	3	8	11	255.522
#248	BNC1	3	7	10	213.969
#249	ETV1	3	12	15	69.841
#250	GCFC1	3	15	18	599.81
#251	MMP14	3	9	12	8236.305
#252	YEATS4	3	13	16	158.941
#253	ETV5	3	6	9	32.624
#254	TBX3	3	6	9	159.902
#255	GTF2I	3	9	12	2170.074
#256	ARNTL	3	10	13	181.86
#257	NR4A2	3	6	9	253.274
#258	YY1	3	7	10	550.723
#259	RERE	3	11	14	183.695
#260	JUNB	3	6	9	286.478
#261	TCF7L2	3	10	13	120.393
#262	PTTG1	3	4	7	966.624
#263	CREB1	3	11	14	407.918
#264	SMAD3	3	14	17	386.484
#265	PHF5A	3	8	11	248.994
#266	ENO1	3	7	10	2466.17
#267	E2F1	3	11	14	163.711
#268	TAF13	3	7	10	23.056
#269	ZNF215	3	9	12	51.865
#270	ZSCAN21	3	6	9	14.933
#271	SHOX	3	7	10	92.335
#272	KLF2	3	8	11	253.153
#273	HCLS1	3	5	8	238.883
#274	ALX1	3	7	10	68.508
#275	SIM1	3	5	8	267.992
#276	GATAD2A	3	11	14	583.997
#277	POU3F2	3	7	10	1990.896
#278	MEF2D	3	9	12	501.102
#279	LHX9	3	6	9	395.357
#280	ZNF85	3	11	14	202.881
#281	TCF19	3	12	15	427.601
#282	AHCTF1	3	9	12	81.063
#283	TARDBP	3	12	15	176.656
#284	PPARG	3	13	16	246.712
#285	DLX4	2	5	7	14.116
#286	HES1	2	12	14	134.482
#287	KLF6	2	10	12	37.757
#288	TEAD2	2	10	12	154.097
#289	MEF2A	2	12	14	836.977
#290	POU2F2	2	7	9	384.372
#291	CREB5	2	4	6	10.811
#292	ETV4	2	9	11	23.607
#293	NFATC4	2	8	10	64.798
#294	SOX8	2	6	8	31.353
#295	BATF	2	6	8	491.622
#296	ZNF643	2	9	11	162.996
#297	IRX5	2	9	11	70.419
#298	CDKN2A	2	6	8	7.65
#299	FOXO6	2	10	12	14.463
#300	TAF5	2	11	13	119.095
#301	RXRA	2	7	9	21.096
#302	SOX12	2	16	18	97.126
#303	ARNT	2	12	14	352.349
#304	ZNF256	2	11	13	371.338
#305	IRF7	2	9	11	31.3
#306	ADNP2	2	3	5	9.708
#307	UHRF1	2	10	12	108.703
#308	ZNF277	2	9	11	199.305
#309	PGR	2	5	7	33.189
#310	SIX4	2	11	13	35.052
#311	ATF3	2	15	17	560.411
#312	HOXA4	2	8	10	18.364
#313	PLAGL2	2	11	13	58.284
#314	FOXQ1	2	5	7	83.136
#315	CBFA2T2	2	13	15	141.85
#316	KDM5A	2	11	13	600.581
#317	FOXD3	2	5	7	19.224
#318	GATA4	2	8	10	16.38
#319	SCAND3	2	10	12	170.859
#320	SLC2A4RG	2	9	11	89.722
#321	GATAD2B	2	7	9	357.579
#322	ZC3H8	2	9	11	59.987
#323	NOTCH1	2	12	14	385.287
#324	SIX5	2	8	10	28.71
#325	ZNF496	2	9	11	81.169
#326	XBP1	2	10	12	48.262
#327	LZTS1	2	4	6	19.915
#328	HOXB4	2	9	11	383.742
#329	HIF1A	2	7	9	129.521
#330	ZSCAN2	2	8	10	72.248
#331	ZNF35	2	7	9	52.573
#332	JUN	2	8	10	15.234
#333	HEY2	2	11	13	31.808
#334	BACH1	2	7	9	73.589
#335	SCAND1	2	6	8	3.9
#336	EN2	2	6	8	64.53
#337	FOXP4	2	10	12	31.548
#338	TBX5	2	9	11	534.508
#339	NFE2L2	2	13	15	59.104
#340	ZNF219	2	11	13	246.854
#341	TADA2A	2	8	10	19.288
#342	SP3	2	12	14	85.962
#343	RBPJ	2	10	12	129.1
#344	LHX2	2	7	9	28.122
#345	TRERF1	2	8	10	52.567
#346	ZNF83	2	11	13	130.516
#347	PITX1	2	5	7	3.016
#348	ELF3	2	11	13	317.953
#349	HMX2	2	9	11	407.821
#350	BCL11B	1	6	7	214.886
#351	ZNF274	1	8	9	65.616
#352	SLC30A9	1	9	10	28.582
#353	NR0B1	1	11	12	11.898
#354	JUND	1	10	11	1054.215
#355	GTF2H4	1	8	9	25.626
#356	TP63	1	8	9	54.463
#357	HEY1	1	12	13	53.803
#358	MLL	1	11	12	31.303
#359	HIC1	1	7	8	276.833
#360	CSRNP3	1	9	10	3.542
#361	SMAD4	1	7	8	8254.98
#362	THRA	1	10	11	26.844
#363	FBXW7	1	10	11	69.043
#364	TAL1	1	12	13	122.859
#365	ZNF397	1	6	7	53.707
#366	ERF	1	8	9	89.961
#367	TRIM29	1	10	11	39.115
#368	ZKSCAN3	1	9	10	22.082
#369	HOXD11	1	8	9	12.078
#370	ZBTB25	1	7	8	9.563
#371	ZHX1	1	8	9	69.704
#372	CREM	1	4	5	7.71
#373	RCAN1	1	10	11	142.029
#374	IRF1	1	8	9	415.362
#375	GAS7	1	7	8	22.667
#376	ATF6	1	8	9	156.893
#377	HMBOX1	1	10	11	33.526
#378	HOXD4	1	10	11	18.911
#379	ISL2	1	11	12	16.043
#380	TGIF2	1	12	13	88.403
#381	TAF4	1	9	10	1222.89
#382	CREB3L4	1	13	14	135.802
#383	NR3C2	1	5	6	7.533
#384	TEAD3	1	12	13	18.55
#385	SIX1	1	11	12	25.056
#386	NR1D2	1	12	13	49.77
#387	KLF3	1	10	11	53.769
#388	HOXD13	1	7	8	13.729
#389	FOXR2	1	6	7	18.857
#390	E2F7	1	14	15	518.414
#391	FLI1	1	4	5	30.617
#392	TSHZ3	1	7	8	170.574
#393	ZNF394	1	10	11	82.427
#394	ZSCAN16	1	13	14	102.09
#395	CNOT7	1	12	13	15.442
#396	TCF12	1	7	8	10.3
#397	ZNF449	1	14	15	28.835
#398	ZNF167	1	11	12	210.226
#399	ZNF639	1	7	8	15.152
#400	STAT1	1	8	9	7.201
#401	TFEC	1	10	11	206.076
#402	ETS1	1	8	9	20.711
#403	HOXC13	1	9	10	29.656
#404	PBX2	1	5	6	18.067
#405	SPIB	1	8	9	88.182
#406	HOXD8	1	9	10	21.7
#407	ZNF193	1	8	9	26.367
#408	NFATC2	1	9	10	23.681
#409	BTG2	1	10	11	603.707
#410	RCOR1	1	8	9	25.65
#411	ZSCAN5A	1	11	12	36.385
#412	TBX15	1	9	10	5.867
#413	NKX2-5	1	10	11	243.762
#414	SOX2	1	14	15	131.666
#415	ZFP37	1	6	7	5.368
#416	NFAT5	1	10	11	12.292
#417	GABPA	1	12	13	83.814
#418	ZXDC	1	7	8	120.393
#419	MNX1	1	6	7	51.49
#420	ZNF207	1	6	7	52.224
#421	HOXC5	0	9	9	0
#422	AR	0	6	6	0
#423	ARID3A	0	8	8	0
#424	FUBP1	0	11	11	0
#425	FOS	0	11	11	0
#426	ZNF45	0	11	11	0
#427	FOXC2	0	8	8	0
#428	HOXC11	0	8	8	0
#429	RELB	0	11	11	0
#430	EGR1	0	11	11	0
#431	ETS2	0	8	8	0
#432	ATF2	0	12	12	0
#433	ZFHX4	0	14	14	0
#434	ZNF148	0	11	11	0
#435	PBX4	0	7	7	0
#436	STAT5A	0	14	14	0
#437	BHLHE40	0	11	11	0
#438	ELK4	0	11	11	0
#439	SOX4	0	9	9	0
#440	ZNF24	0	9	9	0
#441	LHX6	0	12	12	0
#442	RXRG	0	6	6	0
#443	FOXG1	0	7	7	0
#444	HSF2	0	7	7	0
#445	EOMES	0	9	9	0
#446	EGR2	0	11	11	0
#447	CCRN4L	0	12	12	0
#448	TEF	0	13	13	0
#449	MNT	0	11	11	0
#450	HMGA1	0	8	8	0
#451	LMO4	0	10	10	0
#452	ZNF238	0	10	10	0
#453	SOLH	0	17	17	0
#454	ZNF268	0	9	9	0
#455	ISL1	0	10	10	0
#456	SCML2	0	12	12	0
#457	ZNF217	0	6	6	0
#458	DBP	0	9	9	0
#459	SMAD5	0	10	10	0
#460	CEBPA	0	8	8	0
#461	NR2C1	0	10	10	0
#462	MYC	0	8	8	0
#463	HDX	0	11	11	0
#464	ZNF132	0	7	7	0
#465	ARID4A	0	15	15	0
#466	FOXJ3	0	9	9	0
#467	ATF7	0	8	8	0
#468	NPAS2	0	7	7	0
#469	FOXA3	0	6	6	0
#470	ZNF438	0	12	12	0
#471	PRDM2	0	9	9	0
#472	FOXL1	0	10	10	0
#473	SUPT4H1	0	9	9	0
#474	NR1H3	0	9	9	0
#475	EN1	0	9	9	0
#476	ETV3	0	10	10	0
#477	DDIT3	0	13	13	0
#478	ZNF93	0	8	8	0
#479	RFXAP	0	8	8	0
#480	GATA2	0	8	8	0
#481	SIM2	0	10	10	0
#482	ZNF71	0	7	7	0
#483	MSX2	0	8	8	0
#484	ZFP36L1	0	9	9	0
#485	L3MBTL4	0	9	9	0
#486	SPEN	0	6	6	0
#487	THRB	0	9	9	0
#488	BCL3	0	9	9	0
#489	USF1	0	12	12	0
#490	MSRB2	0	10	10	0
#491	KLF10	0	11	11	0
#492	ZNF75D	0	10	10	0
#493	PITX2	0	9	9	0
#494	IRF2	0	14	14	0
#495	ESRRG	0	9	9	0
#496	SIX2	0	5	5	0
#497	LCOR	0	13	13	0
#498	ZGPAT	0	9	9	0
#499	HOXA7	0	13	13	0
#500	ZNF367	0	11	11	0