Hub Rank	Node	Children	Parents	Degree	Betweenness
#1	CREB3L2	51	7	58	882.954
#2	EPAS1	47	5	52	3047.026
#3	HCLS1	44	1	45	16.718
#4	ISL2	43	7	50	1199.386
#5	MITF	43	7	50	497.495
#6	MAF	42	7	49	738.725
#7	RCOR2	42	9	51	2239.714
#8	MAFB	41	1	42	534.647
#9	BCL6	40	7	47	411.484
#10	ZBTB38	40	9	49	2473.395
#11	SP4	39	7	46	975.747
#12	RELA	37	6	43	1525.224
#13	ZFP36L1	37	5	42	1273.306
#14	TAF5	37	6	43	1447.819
#15	TRIM22	36	5	41	183.943
#16	HMGB2	35	5	40	1154.895
#17	TAF10	35	10	45	968.144
#18	THRB	34	8	42	2821.923
#19	TP53	34	9	43	3233.347
#20	RUNX2	34	6	40	5515.495
#21	TEAD4	34	4	38	1193.678
#22	BCL3	33	7	40	955.555
#23	NR3C1	33	9	42	1757.79
#24	ATF5	33	7	40	1590.276
#25	E2F3	32	7	39	1833.778
#26	MYCN	32	11	43	1787.961
#27	ECSIT	32	3	35	316.177
#28	MEIS3P1	32	11	43	5226.153
#29	STAT6	31	10	41	339.547
#30	RARB	30	14	44	6392.253
#31	SMAD6	30	11	41	1795.068
#32	ZSCAN12	30	4	34	688.95
#33	ZNF367	30	4	34	384.12
#34	TFAM	30	11	41	2371.832
#35	SP3	29	13	42	886.723
#36	HDAC2	29	6	35	466.364
#37	CSRNP3	29	11	40	3565.598
#38	GABPB1	29	5	34	930.219
#39	AFF1	29	9	38	3010.086
#40	ZHX2	29	4	33	73.696
#41	ZSCAN16	29	4	33	257.216
#42	HMGA1	29	12	41	980.448
#43	CREBZF	28	5	33	623.339
#44	NPAT	28	13	41	1354.076
#45	ETS1	28	14	42	979.828
#46	TCF12	28	8	36	1162.033
#47	FOSL2	28	5	33	240.653
#48	RUNX1T1	28	14	42	4477.367
#49	FLI1	28	4	32	112.083
#50	SALL1	27	12	39	1265.428
#51	AHR	27	8	35	371.246
#52	MEIS2	27	11	38	4878.275
#53	SIN3A	27	15	42	7530.637
#54	MYBL2	27	7	34	1515.901
#55	CREBL2	27	10	37	2495.871
#56	GLIS3	27	7	34	514.614
#57	NFIA	26	8	34	2298.282
#58	NOLC1	26	8	34	3952.397
#59	JUNB	26	10	36	1021.723
#60	TCF3	26	10	36	1119.953
#61	FOXM1	25	10	35	2487.998
#62	HES1	25	7	32	1084.409
#63	NFATC1	24	11	35	6717.453
#64	TEAD2	24	8	32	1101.791
#65	PBX1	24	10	34	1414.681
#66	PCGF6	24	16	40	5537.421
#67	ZEB2	24	11	35	2635.252
#68	ZNF135	24	11	35	2820.418
#69	E2F2	24	7	31	427.197
#70	ETV5	24	10	34	339.935
#71	C1orf85	24	12	36	1245.21
#72	SIX6	23	12	35	2883.756
#73	AEBP1	23	15	38	964.722
#74	RORA	22	11	33	2771.363
#75	PPARG	22	9	31	2024.205
#76	SOX12	22	8	30	944.526
#77	TCFL5	22	7	29	809.132
#78	TAF12	22	12	34	1034.838
#79	PRRX1	22	12	34	1227.949
#80	NR1H2	22	13	35	2399.2
#81	SMAD2	22	11	33	3399.781
#82	ZBTB48	22	9	31	410.931
#83	BHLHE41	22	11	33	1299.489
#84	FOXP1	22	12	34	3345.316
#85	CRX	22	14	36	4297.804
#86	FOXC1	21	11	32	4797.88
#87	STAT3	21	10	31	890.644
#88	KLF3	21	13	34	2866.566
#89	CREB3L4	21	11	32	1031.427
#90	ZNF445	21	12	33	928.959
#91	UHRF1	21	10	31	358.879
#92	SIX5	21	10	31	1617.747
#93	ZGPAT	20	10	30	632.57
#94	TCF19	20	12	32	842.432
#95	MYT1	20	15	35	777.86
#96	GLI3	20	11	31	1070.367
#97	SMAD9	20	14	34	812.422
#98	PLAGL2	20	9	29	1091.266
#99	NR3C2	20	9	29	1329.8
#100	MSRB2	20	13	33	1793.594
#101	VAX2	20	13	33	898.741
#102	TCF7L2	19	10	29	484.519
#103	MLX	19	11	30	839.451
#104	IRF8	19	8	27	996.666
#105	MEIS1	19	9	28	1178.511
#106	SOX6	19	21	40	5116.384
#107	TBX2	19	10	29	1039.817
#108	TADA3	19	11	30	1546.09
#109	IRX3	19	19	38	3842.353
#110	ZFP37	19	15	34	1695.553
#111	JUND	18	6	24	530.026
#112	RXRG	18	14	32	1009.086
#113	ZXDA	18	12	30	608.203
#114	NEUROD2	18	9	27	713.282
#115	PPARA	18	14	32	400.116
#116	DRAP1	18	4	22	355.615
#117	TAF5L	18	14	32	3313.716
#118	RUNX1	18	8	26	1495.947
#119	TFEB	18	11	29	1001.374
#120	MNX1	18	13	31	1644.446
#121	TCF7L1	17	15	32	9956.534
#122	IRF2	17	14	31	861.661
#123	ZSCAN2	17	8	25	270.641
#124	FOS	17	12	29	499.863
#125	SMAD3	17	17	34	945.414
#126	NEUROD1	17	10	27	878.844
#127	PBX4	17	10	27	451.515
#128	TFDP1	17	14	31	1784.92
#129	GCFC1	17	11	28	1557.44
#130	NFIB	17	16	33	3828.761
#131	LASS6	17	10	27	967.656
#132	FUBP1	16	12	28	878.612
#133	STAT2	16	8	24	769.99
#134	TGIF1	16	13	29	512.749
#135	DLX4	16	9	25	2243.635
#136	KLF9	16	18	34	1475.509
#137	CDKN2A	16	16	32	1141.339
#138	NR1H3	16	10	26	2255.652
#139	ELK3	16	15	31	538.666
#140	SUPT6H	16	8	24	270.591
#141	KLF2	16	16	32	1607.938
#142	CEBPD	16	13	29	1738.353
#143	TFEC	16	6	22	1144.603
#144	LEF1	16	13	29	868.241
#145	E2F1	16	8	24	554.817
#146	HMG20B	16	12	28	1689.575
#147	LHX9	16	13	29	4234.504
#148	ETV6	16	7	23	280.78
#149	TCF4	16	15	31	3621.579
#150	NFYB	15	8	23	1523.907
#151	MAFK	15	10	25	1330.098
#152	NPAS2	15	12	27	2045.73
#153	HSF2	15	10	25	1272.322
#154	FOXN2	15	12	27	2515.037
#155	ZNF71	15	14	29	514.269
#156	ZNF75D	15	8	23	1022.28
#157	ZNF207	15	11	26	2083.341
#158	VAV1	15	7	22	2013.177
#159	PA2G4	15	13	28	782.8
#160	XBP1	15	12	27	2727.041
#161	IRX5	15	5	20	548.342
#162	PLSCR1	15	12	27	1622.167
#163	ZFHX3	15	14	29	3216.433
#164	MEF2C	15	19	34	1166.972
#165	PRDM1	15	18	33	6386.772
#166	LHX3	15	14	29	1178.381
#167	PTTG1	15	13	28	1362.419
#168	CSDA	14	16	30	1785.207
#169	HOPX	14	11	25	154.33
#170	SOX9	14	10	24	305.127
#171	NR2F1	14	12	26	1078.624
#172	SATB2	14	14	28	1069.609
#173	OTX2	14	17	31	2752.592
#174	SIX4	14	19	33	2852.556
#175	RUNX3	14	20	34	2552.85
#176	PGBD1	14	10	24	737.711
#177	ZNF117	14	11	25	890.857
#178	TP73	14	9	23	711.518
#179	ARID4A	14	10	24	1344.167
#180	LASS2	14	17	31	2471.97
#181	ZNF138	14	14	28	1880.789
#182	GABPA	14	9	23	570.605
#183	LCOR	14	17	31	1417.292
#184	POU2F1	14	12	26	738.246
#185	PKNOX2	13	14	27	1632.67
#186	TRIM28	13	10	23	343.716
#187	PITX1	13	12	25	1774.145
#188	RAX	13	11	24	930.106
#189	IRF3	13	10	23	647.625
#190	DLX6	13	2	15	176.444
#191	LHX2	13	18	31	5224.825
#192	ETV1	13	11	24	506.243
#193	ZNF131	13	12	25	2649.965
#194	SCAND3	13	9	22	1158.707
#195	SOX8	13	11	24	1454.676
#196	ZNF643	13	10	23	651.964
#197	CNOT7	13	4	17	911.922
#198	TAF1B	13	10	23	461.263
#199	ZNF83	13	13	26	1168.744
#200	TBX5	13	14	27	1428.541
#201	SOX11	13	16	29	3967.577
#202	HNRNPAB	13	9	22	1521.974
#203	ETS2	13	19	32	4276.512
#204	MGA	12	10	22	439.223
#205	BTG2	12	17	29	1205.516
#206	CEBPB	12	15	27	671.975
#207	GATA2	12	13	25	1600.71
#208	MLL	12	10	22	396.58
#209	VTN	12	17	29	1797.055
#210	RFXAP	12	16	28	876.03
#211	EGR2	12	10	22	337.068
#212	ARNTL	12	10	22	398.475
#213	GATAD2B	12	13	25	1437.376
#214	FOXQ1	12	10	22	3079.424
#215	ONECUT2	12	19	31	1209.079
#216	HOXC9	12	15	27	3926.024
#217	ST18	12	18	30	1472.546
#218	YBX1	12	12	24	1143.671
#219	MEF2A	12	12	24	634.507
#220	TFDP2	11	12	23	745.882
#221	BACH1	11	12	23	1017.473
#222	ATF3	11	15	26	1268.219
#223	EDF1	11	11	22	344.906
#224	RB1	11	23	34	1615.353
#225	CREB5	11	16	27	557.277
#226	FEV	11	20	31	3442.478
#227	LZTS1	11	16	27	1370.298
#228	RBCK1	11	10	21	336.712
#229	SOX2	11	12	23	1672.309
#230	ZFHX4	11	18	29	1150.105
#231	ARNTL2	11	12	23	645.985
#232	NFYA	11	8	19	201.43
#233	C5orf41	11	16	27	1356.891
#234	NR2E1	11	15	26	898.186
#235	SCML2	11	9	20	165.512
#236	ELK4	11	15	26	5952.262
#237	ZNF193	11	11	22	491.42
#238	CBFA2T3	11	13	24	2500.873
#239	ZXDC	11	15	26	1423.547
#240	PROX1	11	3	14	234.766
#241	DLX2	11	9	20	1158.311
#242	TFAP2B	11	11	22	2476.368
#243	LMO4	11	21	32	1558.715
#244	MYOD1	11	18	29	6040.39
#245	C11orf9	11	14	25	1025.447
#246	MTA1	11	13	24	1343.203
#247	FOXK2	11	15	26	1108.318
#248	STAT5A	11	15	26	937.486
#249	DDIT3	11	21	32	2205.58
#250	C2orf3	11	16	27	1245.343
#251	IRF6	10	10	20	491.603
#252	CNOT8	10	6	16	814.843
#253	NKX3-1	10	12	22	1578.401
#254	MLLT10	10	15	25	1269.238
#255	KLF11	10	16	26	2826.282
#256	TFAP2A	10	10	20	931.768
#257	SOX15	10	13	23	2452.932
#258	ZNF628	10	14	24	643.319
#259	RCOR1	10	7	17	630.812
#260	ZIC3	10	12	22	1030.03
#261	ZFP90	10	16	26	1105.698
#262	AHCTF1	10	14	24	636.981
#263	LHX8	10	14	24	1554.274
#264	RORB	10	14	24	1376.352
#265	ATF1	10	11	21	1554.829
#266	BNC1	10	7	17	276.957
#267	LHX4	10	19	29	819.1
#268	CREB1	10	7	17	225.572
#269	PHTF1	10	17	27	1729.832
#270	GTF2H4	9	10	19	533.326
#271	SREBF1	9	11	20	922.371
#272	DMRT2	9	15	24	1202.214
#273	ZNF93	9	20	29	2089.856
#274	TRPS1	9	16	25	782.693
#275	ELF1	9	14	23	417.699
#276	THRA	9	15	24	1302.998
#277	CITED2	9	17	26	1712.526
#278	TGIF2	9	17	26	861.722
#279	HEYL	9	13	22	844.213
#280	ZNF148	9	11	20	523.832
#281	ATF2	9	8	17	259.043
#282	HLF	9	13	22	1139.656
#283	IKZF1	9	9	18	781.727
#284	ZNF45	9	19	28	2181.077
#285	PBX2	9	10	19	677.153
#286	SCAND1	9	10	19	259.333
#287	SOX10	9	13	22	336.634
#288	CEBPA	9	8	17	295.068
#289	DMRT1	9	9	18	972.838
#290	WNT5A	9	15	24	467.942
#291	SLC2A4RG	9	11	20	1660.449
#292	ZNF277	9	12	21	1176.831
#293	TULP4	9	11	20	1578.957
#294	FOXP4	8	15	23	1022.578
#295	ZNF256	8	17	25	1819.062
#296	PITX2	8	9	17	616.472
#297	SIX3	8	17	25	2820.819
#298	PPARD	8	15	23	1758.273
#299	EGR1	8	13	21	731.345
#300	CUX2	8	16	24	376.36
#301	E2F8	8	15	23	839.884
#302	NFE2L2	8	18	26	1090.521
#303	HES6	8	14	22	388.46
#304	FOXN4	8	19	27	3926.287
#305	FOXO3	8	13	21	416.108
#306	TWIST1	8	9	17	5010.598
#307	TFCP2L1	8	12	20	729.204
#308	FOXO6	8	11	19	849.039
#309	SATB1	8	22	30	987.946
#310	KLF5	8	18	26	1749.506
#311	SMAD4	8	16	24	1161.5
#312	BLZF1	8	11	19	318.352
#313	TEAD3	8	16	24	864.839
#314	PAX6	8	14	22	1206.465
#315	ERG	8	9	17	237.813
#316	ZNF167	8	20	28	1718.013
#317	SPEN	8	20	28	1309.03
#318	MECOM	8	12	20	1989.505
#319	TSC22D3	8	15	23	735.497
#320	ZNF639	8	17	25	2130.35
#321	NR2F2	8	20	28	4391.844
#322	PEG3	7	17	24	2772.923
#323	TRERF1	7	17	24	339.646
#324	MYC	7	16	23	835.079
#325	HR	7	19	26	1048.282
#326	ESRRB	7	4	11	33.157
#327	EGR3	7	14	21	1461.298
#328	SCML1	7	16	23	960.667
#329	HAND1	7	18	25	1144.532
#330	SNAI2	7	12	19	408.717
#331	TCF25	7	15	22	852.562
#332	MESP1	7	10	17	443.772
#333	ZNF217	7	18	25	985.85
#334	CSRNP1	7	14	21	754.789
#335	VSX1	7	9	16	253.482
#336	HOXC4	7	13	20	3622.879
#337	TAF4B	7	17	24	1756.777
#338	ZNF92	7	11	18	697.009
#339	NRL	7	16	23	1030.512
#340	KLF6	7	17	24	545.963
#341	ZNF281	7	13	20	1084.394
#342	HOXB7	7	10	17	384.942
#343	E2F7	7	10	17	368.765
#344	SOX7	7	17	24	1049.77
#345	L3MBTL4	7	13	20	516.207
#346	TFAP2E	7	8	15	1417.128
#347	POU4F2	7	20	27	1309.981
#348	ZSCAN18	7	12	19	1043.483
#349	ISL1	7	11	18	492.488
#350	PHF1	7	10	17	229
#351	SIM1	7	4	11	196.816
#352	SOX4	6	19	25	875.346
#353	ZNF396	6	11	17	1661.03
#354	YEATS4	6	12	18	116.448
#355	BHLHE40	6	15	21	507.291
#356	TARDBP	6	7	13	489.057
#357	NR2C1	6	15	21	512.7
#358	CREM	6	13	19	798.043
#359	FOXA3	6	17	23	1541.207
#360	RAX2	6	16	22	1472.639
#361	ZKSCAN1	6	16	22	1916.062
#362	NFAT5	6	16	22	3062.982
#363	DMBX1	6	16	22	3728.375
#364	ZIC2	6	26	32	2440.049
#365	ZNF496	6	15	21	318.917
#366	HOXA9	6	6	12	187.896
#367	GAS7	6	16	22	293.077
#368	TRIM25	6	13	19	1715.002
#369	NFIX	6	13	19	520.077
#370	REL	6	15	21	1417.334
#371	TSHZ1	6	20	26	2172.51
#372	FOXF2	6	15	21	1045.501
#373	PLAG1	6	19	25	2667.161
#374	NR4A1	6	13	19	711.291
#375	IRF5	6	10	16	102.81
#376	FOXN3	6	14	20	605.354
#377	ZNF215	6	17	23	1032.33
#378	ZFP36L2	6	18	24	1084.615
#379	NFIC	6	15	21	1608.873
#380	NR2F6	6	10	16	327.297
#381	NFE2L3	6	17	23	2571.38
#382	HMX2	6	7	13	1851.872
#383	JUN	6	12	18	937.236
#384	NR4A2	6	18	24	878.514
#385	PRDM2	6	14	20	1505.339
#386	HOXB3	6	8	14	198.971
#387	GATAD2A	5	12	17	1030.802
#388	ZNF232	5	15	20	329.635
#389	ZNF70	5	11	16	883.432
#390	TRIM29	5	3	8	166.432
#391	ESRRG	5	17	22	403.307
#392	ZIC1	5	23	28	1048.261
#393	POU2F2	5	15	20	1599.753
#394	GATA6	5	11	16	338.964
#395	NOTCH1	5	16	21	590.367
#396	GATA4	5	13	18	741.339
#397	PAX3	5	6	11	703.834
#398	MSX1	5	16	21	2331.585
#399	ZFPM2	5	16	21	275.412
#400	KLF4	5	12	17	431.671
#401	ZNF140	5	11	16	674.886
#402	EBF1	5	17	22	190.05
#403	DLX1	5	9	14	202.022
#404	ELF4	5	18	23	1435.86
#405	POU4F1	5	22	27	515.241
#406	SOLH	5	11	16	434.336
#407	GATA5	5	15	20	447.83
#408	FOSB	5	9	14	97.619
#409	MXD1	5	13	18	822.199
#410	TSHZ2	5	14	19	255.532
#411	ELF3	5	11	16	633.717
#412	ATF6	4	15	19	996.749
#413	BCL11B	4	23	27	1445.644
#414	TLX2	4	15	19	1416.858
#415	ARID3A	4	13	17	320.18
#416	HHEX	4	20	24	1246.04
#417	RCAN1	4	19	23	147.174
#418	MZF1	4	10	14	628.248
#419	YY1	4	15	19	294.228
#420	HOXD3	4	9	13	1434.037
#421	EHF	4	8	12	336.975
#422	MYCL1	4	18	22	1525.106
#423	ELF2	4	13	17	102.794
#424	ATF7	4	15	19	1796.608
#425	HOXA2	4	18	22	504.987
#426	PHOX2B	4	14	18	474.606
#427	ASCL1	4	11	15	1968.395
#428	POU6F2	4	12	16	750.45
#429	KLF7	4	16	20	1334.049
#430	NKX2-5	4	15	19	408.931
#431	CITED1	4	15	19	186.964
#432	ZEB1	4	18	22	443.408
#433	VDR	4	14	18	175.023
#434	POU6F1	4	16	20	1484.694
#435	HOXA1	3	10	13	463.311
#436	DBP	3	19	22	1144.522
#437	IRF1	3	12	15	286.072
#438	HEY1	3	19	22	788.77
#439	STAT1	3	10	13	46.301
#440	AATF	3	12	15	91.052
#441	ALX1	3	14	17	223.082
#442	NFATC4	3	13	16	855.876
#443	FOXO1	3	16	19	160.425
#444	NR2E3	3	20	23	604.407
#445	NANOG	3	21	24	1169.34
#446	NR1D2	3	13	16	1315.204
#447	SIX2	3	12	15	341.823
#448	SNAPC4	3	14	17	171.897
#449	ZNF236	3	19	22	1029.338
#450	TSHZ3	3	18	21	352.207
#451	SP1	3	17	20	564.055
#452	SOX5	3	17	20	183.956
#453	HIF3A	3	11	14	345.022
#454	MTA3	3	14	17	204.153
#455	KCNH8	3	16	19	497.422
#456	HMGA2	3	27	30	360.851
#457	NKX3-2	3	17	20	270.526
#458	FOXL2	3	12	15	738.599
#459	BACH2	3	12	15	206.376
#460	TBX1	3	12	15	364.336
#461	HMGB1	3	13	16	637.189
#462	MAFF	3	16	19	582.457
#463	ENO1	3	18	21	1065.59
#464	IRF9	2	22	24	348.75
#465	FOXP2	2	26	28	2503.192
#466	TSC22D1	2	10	12	680.488
#467	ZNF85	2	17	19	1197.274
#468	ZNF268	2	13	15	356.342
#469	PURB	2	14	16	217.176
#470	SOX1	2	15	17	336.18
#471	CTBP1	2	16	18	2292.407
#472	IRF7	2	17	19	236.728
#473	NANOGNB	2	18	20	2934.69
#474	CBL	2	9	11	100.978
#475	ZNF165	2	15	17	593.291
#476	ZNF323	2	15	17	170.646
#477	POU3F2	2	14	16	1035.28
#478	ZHX1	2	11	13	105.995
#479	MYNN	2	15	17	85.096
#480	SIX1	2	12	14	437.858
#481	SMAD5	2	15	17	879.69
#482	NFATC3	2	9	11	68.192
#483	GTF2H2	2	16	18	820.786
#484	KLF12	2	17	19	527.191
#485	KDM5B	1	18	19	160.206
#486	ATF6B	1	18	19	1307.501
#487	ARNT	1	13	14	94.037
#488	ZNF91	1	9	10	73.141
#489	HOXB2	1	17	18	23.937
#490	PHOX2A	1	12	13	1081.528
#491	KLF10	1	17	18	58.796
#492	SLC30A9	1	19	20	135.817
#493	FOXD1	1	17	18	300.876
#494	NR4A3	1	15	16	226.402
#495	HEY2	1	21	22	124.485
#496	STAT4	1	13	14	38.033
#497	MYT1L	0	24	24	0
#498	FOXG1	0	31	31	0
#499	ZNF33B	0	20	20	0
#500	HOXD4	0	8	8	0