Hub Rank	Node	Children	Parents	Degree	Betweenness
#1	EVX1	42	4	46	2500.859
#2	HMX1	38	2	40	59.693
#3	PITX3	36	3	39	124.518
#4	HOXB1	35	2	37	65.157
#5	GAS7	34	5	39	2408.833
#6	MAFB	33	6	39	6302.622
#7	ATF2	33	9	42	1216.376
#8	ZNF444	33	6	39	6202.727
#9	PRRX1	32	8	40	1458.035
#10	ZEB1	31	7	38	3724.401
#11	BNC1	31	6	37	1803.324
#12	CREBZF	30	11	41	1656.566
#13	E2F4	29	1	30	146.773
#14	ELK3	28	12	40	3202.804
#15	SMAD4	28	8	36	1915.823
#16	TRPS1	27	12	39	5506.213
#17	ESRRA	27	5	32	983.624
#18	ATF1	27	9	36	13094.336
#19	HNF1B	27	4	31	96.52
#20	RAX	26	4	30	524.992
#21	CITED1	26	8	34	1203.316
#22	TFAM	25	8	33	190.184
#23	WT1	25	9	34	1560.113
#24	HCLS1	25	6	31	1318.943
#25	ZNF140	25	14	39	1009.976
#26	KDM5A	24	8	32	1343.235
#27	STAT6	24	12	36	4827.118
#28	ETV4	24	6	30	350.605
#29	DMTF1	24	11	35	3307.156
#30	KLF10	23	16	39	1963.361
#31	HCFC1	23	5	28	1265.74
#32	CREB1	23	8	31	534.422
#33	MYBL2	23	10	33	1167.82
#34	TSC22D4	23	5	28	497.077
#35	GATA6	23	14	37	2870.903
#36	LHX2	23	7	30	2682.982
#37	MEF2D	22	6	28	398.017
#38	CNBP	22	8	30	3386.176
#39	HOXA11	22	6	28	439.723
#40	NFATC4	22	13	35	1969.737
#41	SATB2	21	14	35	3134.256
#42	PLSCR1	21	5	26	513.095
#43	PHF1	21	13	34	1110.208
#44	HSF4	21	12	33	876.279
#45	TCF12	21	13	34	3068.25
#46	SP3	21	8	29	15146.549
#47	NFE2L2	21	5	26	1943.574
#48	BACH2	21	9	30	1759.256
#49	SNAPC2	21	7	28	795.236
#50	TWIST1	21	9	30	2140.114
#51	RARG	20	5	25	607.332
#52	SOX10	20	9	29	1201.273
#53	TCF15	20	3	23	44.479
#54	ZBTB38	20	7	27	1102.607
#55	GATA2	20	12	32	10398.653
#56	PURA	20	9	29	2813.532
#57	CEBPD	20	16	36	2697.545
#58	GTF2H3	20	6	26	791.88
#59	ZNF148	19	9	28	2096.891
#60	TBX21	19	7	26	1192.183
#61	CLOCK	19	9	28	2629.051
#62	HMGA1	19	9	28	1869.576
#63	IRF8	19	8	27	1002.628
#64	FOXL2	19	7	26	1273.998
#65	ZNF165	19	7	26	2181.545
#66	MITF	19	8	27	3085.566
#67	TCF7	18	11	29	1442.689
#68	ZSCAN16	18	11	29	3077.133
#69	MAFK	18	12	30	2735.09
#70	STAT3	18	15	33	3436.4
#71	HSF1	18	9	27	1903.359
#72	PLAG1	18	8	26	2162.219
#73	HEY1	18	11	29	1161.318
#74	CEBPB	18	11	29	1908.914
#75	USF2	18	10	28	883.439
#76	MYNN	18	9	27	903.492
#77	ADNP	18	11	29	1685.919
#78	CNOT8	18	8	26	538.381
#79	MSL3	17	6	23	381.635
#80	EGR4	17	7	24	148.059
#81	MAF	17	9	26	2445.598
#82	SREBF2	17	9	26	1864.277
#83	ZNF238	17	12	29	1482.635
#84	STRN3	17	8	25	905.36
#85	BHLHE40	17	7	24	497.067
#86	CREB3L1	17	17	34	3079.221
#87	BATF	17	7	24	954.876
#88	VAV1	17	2	19	137.879
#89	ZFHX4	17	11	28	2927.324
#90	BTG2	17	8	25	1017.818
#91	GATAD1	17	13	30	2668.377
#92	MLXIPL	17	4	21	40.108
#93	TFCP2	17	11	28	1157.273
#94	PRDM1	17	7	24	1394.953
#95	DRAP1	17	7	24	2488.215
#96	MECOM	17	11	28	1812.3
#97	ERG	17	9	26	465.945
#98	E2F1	17	10	27	383.167
#99	ZKSCAN5	17	7	24	402.134
#100	PTTG1	17	5	22	571.433
#101	TFEC	16	5	21	229.226
#102	SNAPC4	16	13	29	4140.048
#103	KLF2	16	13	29	1874.795
#104	SATB1	16	15	31	3609.93
#105	ZNF217	16	10	26	2794.051
#106	VDR	16	6	22	1052.966
#107	JUNB	16	3	19	248.159
#108	ATF6B	16	10	26	2164.816
#109	MEIS2	16	9	25	928.479
#110	TEAD4	16	11	27	920.015
#111	MLX	16	10	26	1502.735
#112	FLI1	16	6	22	1118.254
#113	ZNF3	16	10	26	1173.969
#114	ZEB2	16	8	24	1560.922
#115	ELF2	16	11	27	1354.469
#116	FUBP1	16	7	23	242.236
#117	MEF2A	16	10	26	1759.966
#118	C11orf9	16	10	26	2077.412
#119	RELB	15	11	26	1086.079
#120	ZNF189	15	12	27	699.337
#121	NFE2L1	15	13	28	1793.84
#122	RUNX3	15	3	18	206.641
#123	TFAP4	15	8	23	274.287
#124	IKZF1	15	6	21	888.845
#125	NR3C1	15	10	25	1842.886
#126	SCMH1	15	10	25	2720.631
#127	NFIC	15	7	22	1632.162
#128	FOXN3	15	8	23	669.709
#129	SOX4	15	14	29	1684.331
#130	CREB5	15	8	23	1090.469
#131	SUPT4H1	15	7	22	466.166
#132	SNAI2	15	14	29	1748.744
#133	FOXO1	15	12	27	1451.674
#134	CSDA	15	11	26	1265.774
#135	TSHZ2	15	10	25	2198.368
#136	STAT4	15	7	22	463.738
#137	HMG20A	15	9	24	1914.72
#138	SPI1	15	8	23	671.364
#139	KDM5B	15	5	20	371.656
#140	BCL11B	15	6	21	1158.892
#141	FOSL1	14	11	25	1583.42
#142	ARNTL2	14	15	29	2698.489
#143	KLF9	14	15	29	1258.31
#144	ZNF83	14	14	28	1773.914
#145	NR4A3	14	7	21	951.081
#146	TRIM22	14	11	25	1189.125
#147	ELK1	14	11	25	300.433
#148	GRHL2	14	6	20	3206
#149	RUNX1	14	7	21	341.041
#150	TAF6	14	8	22	1015.657
#151	NR4A1	14	5	19	675.87
#152	HMGA2	14	12	26	1669.449
#153	BCL3	14	17	31	3010.091
#154	FOXM1	14	10	24	1018.672
#155	IRF1	14	8	22	1305.456
#156	ZNF91	14	11	25	1996.023
#157	AFF1	14	17	31	3238.079
#158	MEF2C	14	11	25	2669.143
#159	TCF20	14	12	26	834.366
#160	ZNF394	14	13	27	2740.234
#161	SPDEF	14	6	20	1092.54
#162	NFKB1	13	12	25	1466.933
#163	MSX1	13	9	22	1369.108
#164	E4F1	13	11	24	783.246
#165	CREB3	13	11	24	2398.664
#166	HOXD4	13	13	26	2328.287
#167	ETV1	13	10	23	558.969
#168	RBPJ	13	12	25	1605.325
#169	PRDM2	13	7	20	1375.442
#170	IRF3	13	8	21	497.286
#171	ZNF133	13	8	21	820.699
#172	NANOG	13	11	24	1801.869
#173	NFIL3	13	9	22	1396.37
#174	FOXJ1	13	10	23	228.629
#175	YBX1	13	7	20	1696.476
#176	ZFPM2	13	21	34	2219.539
#177	TCFL5	13	9	22	412.475
#178	ZKSCAN1	13	8	21	607.227
#179	ARNT	13	11	24	682.611
#180	TCF25	13	5	18	510.757
#181	PA2G4	13	10	23	1219.814
#182	ENO1	13	6	19	797.535
#183	HOPX	13	11	24	2232.038
#184	TSC22D3	12	17	29	1805.921
#185	NR2E3	12	7	19	163.514
#186	CBFA2T2	12	7	19	524.311
#187	DDIT3	12	7	19	579.384
#188	ATF3	12	9	21	760.516
#189	SMAD2	12	10	22	702.459
#190	TBX3	12	10	22	1538.263
#191	TCF4	12	22	34	2432.712
#192	ELF4	12	13	25	1945.685
#193	EGR1	12	10	22	1028.109
#194	HR	12	5	17	91.172
#195	IRF4	12	7	19	242.496
#196	KLF6	12	7	19	723.34
#197	PKNOX1	12	7	19	1312.42
#198	SP140	12	3	15	50.196
#199	E2F5	12	13	25	1582.5
#200	HOXA4	12	7	19	389.707
#201	FOS	12	7	19	999.4
#202	TAF12	12	7	19	1452.429
#203	RORC	12	12	24	802.811
#204	PPARG	12	10	22	1941.545
#205	HOXB3	11	6	17	892.604
#206	EGR2	11	10	21	1521.673
#207	ASCL1	11	10	21	669.737
#208	EGR3	11	5	16	1141.737
#209	TSC22D1	11	14	25	1110.801
#210	JUND	11	12	23	1066.023
#211	HDAC2	11	12	23	1072.091
#212	ZNF175	11	6	17	738.107
#213	ZNF167	11	15	26	6017.4
#214	YY1	11	10	21	1942.173
#215	CREBBP	11	7	18	353.697
#216	KLF7	11	15	26	1584.034
#217	MLL	11	8	19	823.762
#218	SOX17	11	9	20	1421.682
#219	GCFC1	11	13	24	975.22
#220	NFKB2	11	16	27	613.23
#221	PRRX2	11	16	27	920.132
#222	ATF4	11	9	20	511.132
#223	MGA	11	9	20	759.034
#224	BATF3	11	10	21	1165.39
#225	HOXC4	11	14	25	2844.164
#226	ZNF75D	11	7	18	1581.105
#227	NR1H3	10	11	21	1395.144
#228	UBN1	10	10	20	667.378
#229	GLI2	10	14	24	1657.651
#230	GTF2I	10	13	23	2065.042
#231	TAF5	10	8	18	424.098
#232	RB1	10	14	24	345.521
#233	RORA	10	13	23	1254.937
#234	MZF1	10	11	21	694.763
#235	GABPB1	10	9	19	288.907
#236	MNT	10	13	23	1520.722
#237	ZNF45	10	13	23	1942.178
#238	ETV7	10	13	23	451.723
#239	GABPA	10	10	20	544.171
#240	LASS6	10	11	21	1204.03
#241	ZNF131	10	9	19	522.667
#242	HSF2	10	9	19	406.414
#243	NR2C1	10	14	24	16279.17
#244	ETV5	10	9	19	2741.999
#245	AHR	10	15	25	1503.23
#246	STAT5B	10	15	25	1815.288
#247	YEATS4	10	7	17	2740.701
#248	BHLHE41	10	15	25	1267.175
#249	FOSB	10	3	13	133.551
#250	DLX4	10	10	20	1881.773
#251	TCF21	10	9	19	748.069
#252	AEBP1	10	20	30	1829.714
#253	TFE3	10	10	20	1160.629
#254	TP53	10	15	25	1529.924
#255	SLC2A4RG	10	14	24	1355.305
#256	ZHX2	10	12	22	1680.194
#257	TRIM28	10	15	25	1013.045
#258	IRF6	9	10	19	2225.746
#259	SHOX	9	7	16	1138.695
#260	SALL2	9	14	23	1450.681
#261	THRA	9	12	21	725.018
#262	ZNF24	9	9	18	846.09
#263	JUN	9	15	24	1097.302
#264	GLI3	9	11	20	1166.099
#265	ELF1	9	15	24	1139.364
#266	PAX3	9	12	21	1396.089
#267	CITED2	9	19	28	1379.173
#268	ZNF33B	9	9	18	1675.458
#269	ZNF323	9	15	24	1074.217
#270	ATF6	9	9	18	687.426
#271	NR5A2	9	3	12	385.506
#272	CREBL2	9	17	26	1294.998
#273	NFE2	9	11	20	681.329
#274	TCF7L2	9	14	23	684.25
#275	FOXD1	9	14	23	978.754
#276	CREB3L2	9	12	21	2437.856
#277	TCEAL1	9	12	21	683.436
#278	TARDBP	9	9	18	2395.425
#279	CBFB	9	14	23	783.621
#280	DBP	9	15	24	1590.869
#281	TCF3	9	11	20	1057.219
#282	MEIS3P1	9	18	27	1329.743
#283	FOXK2	9	8	17	783.991
#284	E2F3	9	14	23	2179.451
#285	HMG20B	9	9	18	570.424
#286	NR2F6	9	15	24	1302.696
#287	IRF9	9	11	20	824.406
#288	POU2F3	9	8	17	2516.706
#289	PBX1	9	12	21	533.38
#290	NR3C2	9	19	28	2279.867
#291	CNOT7	9	10	19	2042.908
#292	RCOR1	8	11	19	1278.654
#293	SIX1	8	8	16	229.053
#294	ZNF268	8	16	24	1080.16
#295	NFAT5	8	5	13	571.705
#296	EPAS1	8	16	24	1579.836
#297	CSRNP2	8	11	19	374.903
#298	SOX12	8	14	22	922.552
#299	HES1	8	15	23	1354.558
#300	ZNF277	8	16	24	702.4
#301	UBP1	8	11	19	3847.831
#302	TCF7L1	8	19	27	1107.669
#303	HOXC10	8	11	19	932.173
#304	HOXA10	8	14	22	787.706
#305	ZIC1	8	14	22	1364.936
#306	CUX1	8	10	18	495.603
#307	TFAP2C	8	17	25	958.241
#308	ZNF202	8	13	21	1610.901
#309	TADA3	8	11	19	788.397
#310	TAL1	8	6	14	567.669
#311	SOX13	8	11	19	2125.289
#312	FOXC1	8	12	20	1145.595
#313	RFXAP	8	6	14	457.662
#314	ZNF236	8	4	12	246.775
#315	KLF3	8	9	17	802.827
#316	NR1H2	8	14	22	890.802
#317	ELF3	8	16	24	1594.786
#318	NR2F2	8	16	24	803.241
#319	PAX8	8	8	16	238.911
#320	PEG3	8	13	21	910.499
#321	ZNF207	8	7	15	436.232
#322	TAF10	8	8	16	997.379
#323	E2F6	8	11	19	783.163
#324	HOXB13	8	8	16	1030.815
#325	NFYA	8	12	20	2380.612
#326	REL	8	20	28	3357.74
#327	XBP1	8	16	24	1519.327
#328	MAX	8	13	21	1060.464
#329	NFX1	7	6	13	547.436
#330	TEAD1	7	15	22	2454.835
#331	HIF1A	7	13	20	1438.915
#332	NR4A2	7	12	19	383.999
#333	HOXB6	7	16	23	1935.279
#334	NCOR1	7	13	20	680.375
#335	ZNF232	7	12	19	940.77
#336	HOXB2	7	19	26	1152.986
#337	SPIB	7	7	14	586.147
#338	TAF7	7	17	24	1038.449
#339	ZNF500	7	9	16	598.722
#340	ZIC3	7	4	11	182.065
#341	MTA1	7	15	22	2090.034
#342	PBX2	7	15	22	1114.43
#343	ECSIT	7	15	22	964.663
#344	ZGPAT	7	9	16	548.67
#345	GTF2H4	7	14	21	1399.997
#346	RXRB	7	13	20	1461.681
#347	FOSL2	7	16	23	1175.708
#348	FOXJ3	7	14	21	1502.404
#349	HOXA2	7	9	16	748.027
#350	FOXG1	7	7	14	2424.166
#351	TAF4	7	11	18	15952.292
#352	IRF7	7	12	19	501.501
#353	ZFHX3	7	10	17	589.447
#354	BACH1	7	9	16	551.743
#355	NFYC	7	14	21	1043.228
#356	ZNF135	7	16	23	1333.297
#357	TFEB	7	12	19	1943.902
#358	MYC	7	11	18	703.616
#359	KLF5	7	16	23	734.44
#360	HIC1	7	16	23	723.828
#361	IRF2	7	13	20	560.396
#362	ALX3	7	12	19	709.862
#363	MEIS1	7	22	29	1229.475
#364	ETS2	7	13	20	1110.762
#365	RBCK1	7	13	20	877.498
#366	TFAP2A	7	14	21	2561.082
#367	SMAD6	7	13	20	1491.604
#368	TSC22D2	7	12	19	1500.367
#369	NR1D2	7	13	20	2024.506
#370	RFX5	7	11	18	978.932
#371	FOXO4	6	6	12	43.673
#372	STAT2	6	12	18	872.377
#373	HOXB7	6	15	21	1173.298
#374	NFATC3	6	18	24	2312.246
#375	ZNF187	6	12	18	722.371
#376	ISL1	6	10	16	956.208
#377	LMO4	6	17	23	2041.866
#378	NFATC1	6	15	21	1702.425
#379	KLF4	6	22	28	1218.466
#380	ZNF117	6	17	23	845.422
#381	RCAN1	6	16	22	1228.497
#382	WNT5A	6	18	24	741.503
#383	PBX3	6	16	22	2099.341
#384	PITX1	6	14	20	545.762
#385	FOXF2	6	15	21	853.085
#386	AR	6	11	17	1006.358
#387	SOX9	6	21	27	1681.47
#388	VTN	6	24	30	1843.001
#389	EDF1	6	13	19	665.789
#390	LZTR1	6	9	15	220.497
#391	RARA	6	15	21	542.548
#392	TRIM29	6	17	23	1655.745
#393	SMAD3	6	17	23	895.047
#394	PAX6	6	16	22	702.54
#395	MLLT10	6	14	20	1000.043
#396	TBX1	6	5	11	401.146
#397	SPEN	6	10	16	480.777
#398	C2orf3	6	16	22	727.747
#399	SNAPC5	6	10	16	746.49
#400	ZNF193	6	9	15	323.279
#401	ARID4A	6	12	18	846.309
#402	HMGB2	6	14	20	974.648
#403	GATA4	6	13	19	1332.836
#404	HOXB5	6	13	19	363.745
#405	RFXANK	5	12	17	777.001
#406	STAT1	5	11	16	260.811
#407	NR2F1	5	16	21	855.622
#408	FOXF1	5	11	16	358.342
#409	NFIB	5	16	21	741.783
#410	NFYB	5	18	23	1690.388
#411	MYCN	5	15	20	1114.154
#412	BCL6	5	22	27	2568.003
#413	NPAS2	5	18	23	1994.746
#414	SCML1	5	15	20	1316.23
#415	MSRB2	5	14	19	503.112
#416	E2F8	5	14	19	1797.539
#417	TGIF1	5	15	20	900.334
#418	NKX3-1	5	12	17	553.317
#419	RXRA	5	16	21	870.127
#420	HDAC1	5	15	20	468.948
#421	BTAF1	5	15	20	931.765
#422	ATF5	5	14	19	356.418
#423	ARNTL	5	15	20	647.112
#424	NOLC1	5	19	24	1347.71
#425	HOXA1	5	10	15	963.661
#426	SLC30A9	5	14	19	336.037
#427	NOTCH1	5	17	22	2037.303
#428	LASS2	5	17	22	918.897
#429	GATAD2A	5	13	18	373.248
#430	NPAT	5	11	16	1094.598
#431	TAF1B	5	8	13	384.101
#432	LEF1	4	14	18	688.174
#433	SREBF1	4	10	14	799.496
#434	TULP4	4	11	15	915.156
#435	ZBTB25	4	13	17	913.901
#436	PPARD	4	10	14	377.579
#437	SCAND1	4	13	17	357.071
#438	TBX2	4	12	16	327.095
#439	TEAD3	4	11	15	1522.095
#440	SMAD5	4	9	13	75.079
#441	SOLH	4	10	14	498.026
#442	SIM2	4	12	16	287.742
#443	HHEX	4	9	13	273.162
#444	MEOX1	4	11	15	521.712
#445	MEOX2	4	20	24	508.789
#446	PCGF2	4	19	23	2277.79
#447	TGIF2	4	18	22	1174.945
#448	ERF	4	12	16	336.927
#449	PHTF1	4	17	21	2074.764
#450	RUNX1T1	4	18	22	522.578
#451	MYCL1	4	11	15	377.335
#452	NFE2L3	4	17	21	499.83
#453	SIX2	4	12	16	419.801
#454	ZFP36L2	4	13	17	285.616
#455	SMAD1	4	12	16	489.173
#456	ZBTB17	4	15	19	961.324
#457	IRF5	4	9	13	195.96
#458	MAFF	3	19	22	1225.805
#459	GATA3	3	18	21	279.931
#460	MAFG	3	13	16	1274.265
#461	RNF4	3	10	13	303.253
#462	ZFP36L1	3	18	21	679.89
#463	NR0B1	3	9	12	202.639
#464	CDKN2A	3	15	18	474.123
#465	CTNNB1	3	27	30	1108.808
#466	ZHX3	3	14	17	442.306
#467	BRD8	3	12	15	1048.372
#468	TFDP2	3	12	15	595.376
#469	TFDP1	3	16	19	374.214
#470	ZNF219	3	9	12	372.508
#471	ADNP2	3	12	15	683.213
#472	IRX5	3	9	12	147.516
#473	ZNF281	3	13	16	662.506
#474	AHCTF1	3	10	13	205.276
#475	BUD31	3	14	17	1086.179
#476	KLF11	3	12	15	437.626
#477	CREM	3	14	17	300.053
#478	SOX15	3	14	17	403.064
#479	FOXO3	3	13	16	224.076
#480	RERE	3	9	12	239.175
#481	ZSCAN18	3	13	16	1141.129
#482	SOX11	2	14	16	154.2
#483	GTF2IRD1	2	16	18	211.003
#484	ZNF93	2	11	13	227.15
#485	HNRNPAB	2	18	20	1502.564
#486	FBXW7	2	14	16	236.041
#487	CEBPA	2	14	16	213.614
#488	HMBOX1	2	15	17	337.76
#489	HIRA	2	15	17	379.73
#490	CTBP1	2	12	14	514.855
#491	EN1	2	17	19	676.444
#492	HOXA5	2	15	17	188.92
#493	HMGB1	1	13	14	49.259
#494	HLF	1	16	17	513.273
#495	ARNT2	1	16	17	88.512
#496	SRF	1	15	16	567.961
#497	ZNF274	1	17	18	206.211
#498	PITX2	1	7	8	104.154
#499	MMP14	1	21	22	216.675
#500	MSC	1	12	13	75.843