Hub Rank	Node	Children	Parents	Degree	Betweenness
#1	PHTF1	96	3	99	1140.217
#2	ASCL2	88	2	90	983.255
#3	IRX2	77	5	82	692.856
#4	SOX18	73	5	78	1024.632
#5	PBX1	64	4	68	581.035
#6	MEIS2	48	10	58	22665.092
#7	TRIM29	47	3	50	6727.72
#8	HOXB2	43	6	49	658.649
#9	RUNX3	43	4	47	685.816
#10	NFIA	42	4	46	5182.95
#11	FOXO1	40	8	48	1217.292
#12	TCEAL1	39	7	46	1843.233
#13	PRRX2	37	8	45	4237.802
#14	SIM2	36	8	44	608.186
#15	ARNT2	35	10	45	3123.397
#16	HAND1	35	2	37	1993.88
#17	SNAI2	35	8	43	945.042
#18	FOXA1	35	6	41	789.954
#19	SIX5	32	10	42	1595.596
#20	RUNX2	32	6	38	2939.179
#21	FOXQ1	31	7	38	664.386
#22	ECSIT	31	8	39	2249.507
#23	GRHL2	30	7	37	2567.486
#24	MEIS1	30	7	37	505.13
#25	HOMEZ	29	2	31	37.99
#26	ZNF256	29	6	35	270.856
#27	PAX6	29	5	34	2997.198
#28	KDM5B	27	5	32	251.062
#29	MEF2D	27	8	35	1487.029
#30	MITF	27	7	34	296.267
#31	IRX4	27	8	35	6148.036
#32	MAX	26	9	35	909.823
#33	HOXC6	25	5	30	1045.988
#34	KLF9	25	12	37	3407.892
#35	CREB3L2	25	10	35	2528.657
#36	SALL2	25	3	28	177.375
#37	ISL1	25	5	30	9119.505
#38	ESRRA	25	4	29	270.348
#39	SATB2	25	10	35	1297.649
#40	ZHX2	24	6	30	443.87
#41	ZNF165	24	5	29	564.46
#42	EHF	24	7	31	752.132
#43	TCFL5	24	7	31	435.348
#44	MKX	24	15	39	8161.814
#45	ETS1	24	9	33	2219.955
#46	PGBD1	23	6	29	1225.13
#47	STAT6	22	8	30	2336.747
#48	BATF3	22	11	33	1297.847
#49	PPARG	21	8	29	538.841
#50	SOX4	21	7	28	362.986
#51	HOPX	21	4	25	332.065
#52	TSHZ3	21	12	33	6503.423
#53	ZC3H8	20	12	32	1560.882
#54	DLX3	20	7	27	551.946
#55	PBX3	20	8	28	774.454
#56	CBFB	20	8	28	1174.427
#57	ZNF18	20	8	28	977.306
#58	RXRA	19	7	26	440.213
#59	SCMH1	19	8	27	4646.4
#60	BHLHE40	19	11	30	10537.748
#61	ZNF83	19	10	29	1602.785
#62	ZNF281	19	6	25	491.747
#63	LEF1	18	13	31	797.419
#64	SOX15	18	5	23	289.852
#65	MYC	18	12	30	6644.04
#66	BNC1	18	6	24	268.575
#67	NFX1	18	12	30	5909.438
#68	ZSCAN21	17	11	28	1016.858
#69	PITX1	17	6	23	165.719
#70	ZNF219	17	9	26	579.662
#71	HOXC4	17	8	25	678.851
#72	AATF	17	8	25	851.445
#73	PHF5A	17	3	20	789.584
#74	EOMES	17	5	22	748.854
#75	MYNN	17	7	24	6185.537
#76	FOXE1	16	9	25	2397.174
#77	TSC22D4	16	11	27	954.555
#78	LZTR1	16	6	22	645.185
#79	HES6	16	10	26	1317.839
#80	HOXC9	16	9	25	1276.525
#81	NFKB2	16	7	23	221.25
#82	ZHX1	16	8	24	341.913
#83	ZKSCAN4	16	6	22	4576.432
#84	HOXA13	16	8	24	1109.36
#85	MSX1	16	13	29	1239.492
#86	ZNF193	16	9	25	757.084
#87	FBXW7	16	7	23	2939.46
#88	TP63	15	4	19	253.614
#89	RELA	15	11	26	3444.332
#90	ZFP37	15	11	26	2628.864
#91	C5orf41	15	11	26	1226.19
#92	NKX2-1	15	10	25	2781.213
#93	HOXA4	15	11	26	3344.204
#94	NR2F6	14	6	20	488.391
#95	TSC22D3	14	9	23	3929.701
#96	PRDM1	14	7	21	24016.23
#97	POU2F1	14	9	23	859.115
#98	BUD31	14	11	25	621.891
#99	HNRNPK	14	6	20	7914.723
#100	GAS7	14	4	18	603.668
#101	HOXC8	14	10	24	925.77
#102	CSRNP2	13	13	26	744.295
#103	CEBPB	13	7	20	646.817
#104	HOXB4	13	10	23	1232.131
#105	ELK3	13	6	19	181.958
#106	CTNNB1	13	6	19	16422.075
#107	CNBP	13	11	24	612.669
#108	ETV4	13	8	21	4719.427
#109	RERE	13	11	24	6291.442
#110	DRAP1	13	14	27	937.652
#111	POU4F1	13	5	18	3768.363
#112	ETV5	13	5	18	817.188
#113	TAF1B	13	7	20	412.059
#114	FOXO4	13	16	29	3236.089
#115	KLF2	13	12	25	13757.972
#116	HEY1	12	8	20	1774.102
#117	MECOM	12	10	22	626.819
#118	FOXF1	12	8	20	369.124
#119	TFAP2E	12	2	14	43.055
#120	TAF4	12	8	20	949.387
#121	GLI3	12	11	23	599.151
#122	SLC2A4RG	12	12	24	624.173
#123	TEAD2	12	11	23	702.964
#124	PHF1	12	7	19	10809.832
#125	E4F1	12	8	20	35882.759
#126	LASS2	12	8	20	571.589
#127	FOXJ2	12	8	20	264.742
#128	VAV1	12	7	19	227.761
#129	NFE2	12	14	26	7966.782
#130	EGR1	12	18	30	6504.624
#131	PITX2	12	10	22	3507.673
#132	FOSL1	12	10	22	1438.331
#133	LASS5	12	12	24	308.256
#134	TBP	12	10	22	476.668
#135	ELF3	12	15	27	4234.682
#136	ZFP90	12	9	21	314.077
#137	ZKSCAN2	12	5	17	360.168
#138	PLAGL2	12	7	19	520.197
#139	SCAND1	12	10	22	11530.172
#140	SMAD6	12	8	20	888.466
#141	ZNF189	12	14	26	1759.96
#142	NFYB	12	11	23	2071.414
#143	TFAP2A	11	9	20	214.303
#144	ZBTB48	11	9	20	10417.947
#145	E2F1	11	9	20	618.355
#146	MAFB	11	14	25	3175.393
#147	NR1H3	11	10	21	365.693
#148	IRF6	11	8	19	949.416
#149	IRF1	11	9	20	40594.306
#150	LHX2	11	11	22	5713.38
#151	FOXM1	11	8	19	2160.975
#152	CNOT7	11	6	17	2256.825
#153	AHCTF1	11	10	21	748.868
#154	PCGF6	11	10	21	10801.838
#155	FOXL2	11	8	19	606.395
#156	SMAD4	11	8	19	661.142
#157	ZHX3	11	13	24	1030.535
#158	PAX8	11	9	20	1025.616
#159	TCF19	10	8	18	1078.513
#160	TAF7	10	7	17	636.857
#161	BCL11B	10	9	19	639.174
#162	NR4A2	10	14	24	3085.557
#163	KLF5	10	11	21	1145.853
#164	ETV6	10	14	24	1790.008
#165	HOXA2	10	3	13	502.193
#166	EPAS1	10	11	21	10293.388
#167	CTBP1	10	4	14	585.131
#168	ZNF217	10	10	20	45995.585
#169	E2F6	10	11	21	7408.185
#170	TADA2A	10	9	19	591.479
#171	SMAD2	10	8	18	633.29
#172	ZFP36L1	10	9	19	2440.754
#173	CSRNP1	10	13	23	2364.934
#174	GATA2	10	9	19	1260.759
#175	TADA3	10	11	21	357.49
#176	BTAF1	10	7	17	22200.111
#177	HOXA10	10	9	19	2890.593
#178	ZNF133	10	8	18	3519.146
#179	LHX1	10	6	16	3380.618
#180	ZKSCAN1	10	9	19	281.508
#181	TCF25	10	11	21	6789.307
#182	HOXA5	9	10	19	1024.097
#183	ATF5	9	10	19	601.808
#184	CDKN2A	9	11	20	2556.616
#185	HDAC1	9	9	18	302.678
#186	ZKSCAN5	9	9	18	718.813
#187	MSL3	9	11	20	4098.675
#188	ZNF134	9	3	12	51.826
#189	NR3C1	9	10	19	821.305
#190	KLF12	9	10	19	344.139
#191	FOXN1	9	8	17	1374.543
#192	GATA3	9	5	14	371.202
#193	FOSB	9	5	14	4191.626
#194	STAT1	9	14	23	1215.101
#195	LASS6	9	8	17	1624.507
#196	NPAT	9	9	18	973.326
#197	SNAPC5	9	8	17	247.227
#198	NFIL3	9	8	17	7518.255
#199	CCRN4L	9	14	23	4008.094
#200	ZSCAN5A	9	9	18	262.013
#201	HOXD11	9	7	16	3976.529
#202	HOXB8	8	10	18	660.288
#203	HDAC2	8	8	16	300.033
#204	RFX1	8	9	17	7644.934
#205	UBP1	8	10	18	513.711
#206	CEBPA	8	10	18	476.412
#207	MNX1	8	8	16	4669.185
#208	ZNF274	8	14	22	1336.982
#209	KLF6	8	14	22	2965.798
#210	MLL	8	10	18	843.346
#211	TFDP2	8	10	18	1171.414
#212	MESP1	8	8	16	818.21
#213	VAX2	8	10	18	1623.703
#214	CREB5	8	13	21	21126.612
#215	NOTCH1	8	10	18	523.665
#216	ZBTB25	8	8	16	182.211
#217	IRX3	8	11	19	545.672
#218	ZFP42	8	9	17	3528.026
#219	TFDP1	8	10	18	487.139
#220	RUNX1	8	7	15	1013.334
#221	NR2C1	8	7	15	10672.671
#222	SLC30A9	8	7	15	765.352
#223	SMAD9	8	9	17	1496.086
#224	SOX9	8	10	18	1715.457
#225	TRIM28	8	11	19	22864.484
#226	CDX2	8	6	14	683.007
#227	HES5	8	7	15	13593.804
#228	ZXDA	8	9	17	206.734
#229	ATF3	8	11	19	1359.097
#230	C1orf85	8	7	15	6724.172
#231	BTG2	7	16	23	47145.264
#232	TSHZ1	7	10	17	623.689
#233	PURA	7	10	17	1381.105
#234	HINFP	7	10	17	1165.584
#235	PA2G4	7	10	17	1838.438
#236	ZEB2	7	10	17	138.61
#237	HSF2	7	8	15	222.429
#238	LBX2	7	4	11	208.548
#239	HOXC13	7	10	17	1503.337
#240	FOS	7	8	15	1796.545
#241	ZNF394	7	5	12	173.572
#242	CNOT8	7	10	17	1332.614
#243	SOX21	7	11	18	6426.703
#244	SIX4	7	13	20	4940.48
#245	TSC22D1	7	12	19	39043.183
#246	ZNF187	7	6	13	3613.12
#247	TARDBP	7	14	21	2194.921
#248	FOXN2	7	11	18	1168.099
#249	ZNF323	7	10	17	7318.02
#250	HES1	7	14	21	3055.891
#251	NFE2L3	7	10	17	339.45
#252	STAT4	7	6	13	302.649
#253	FOXF2	7	12	19	969.425
#254	SP3	7	8	15	685.644
#255	E2F5	7	13	20	3363.259
#256	ZNF213	7	13	20	4773.492
#257	ATF2	6	12	18	1746.604
#258	TFAM	6	9	15	3369.751
#259	YEATS4	6	9	15	557.724
#260	RNF4	6	8	14	1676.517
#261	RBCK1	6	9	15	334.83
#262	EGR2	6	11	17	19576.481
#263	TBX2	6	8	14	2750.6
#264	IRF7	6	13	19	187.026
#265	TAF5	6	7	13	1169.966
#266	ELF1	6	11	17	2935.34
#267	CEBPD	6	8	14	332.535
#268	ZIC2	6	9	15	196.28
#269	ESR1	6	7	13	1208.091
#270	NKX3-1	6	9	15	1678.031
#271	ELK1	6	12	18	1329.05
#272	BCL3	6	13	19	972.793
#273	ETS2	6	15	21	4163.482
#274	ATF1	6	8	14	15140.458
#275	PCGF2	6	9	15	2008.45
#276	HHEX	6	6	12	531.708
#277	BLZF1	6	9	15	854.964
#278	E2F2	6	9	15	1015.625
#279	NOLC1	6	16	22	6365.48
#280	ERF	6	9	15	489.532
#281	ADNP	6	8	14	21538.875
#282	AHR	6	8	14	2705.76
#283	NPAS1	6	13	19	1099.144
#284	SREBF2	6	15	21	302.39
#285	ZNF3	6	9	15	1775.797
#286	MZF1	6	14	20	772.89
#287	SIX2	6	4	10	43.67
#288	CSDA	6	12	18	620.258
#289	ZNF263	6	12	18	717.815
#290	SNAPC4	6	10	16	10432.148
#291	HNRNPAB	6	10	16	2353.336
#292	E2F7	6	8	14	1593.838
#293	NFIC	6	10	16	745.395
#294	SIX1	6	10	16	199.119
#295	TFCP2L1	6	11	17	205.413
#296	TP53	6	12	18	2400.316
#297	MEF2A	6	11	17	3331.21
#298	FOXJ3	5	10	15	2073.977
#299	MAF	5	8	13	400.482
#300	KLF10	5	9	14	514.848
#301	BCL6	5	11	16	1246.544
#302	HIF1A	5	15	20	4173.373
#303	LHX6	5	11	16	418.351
#304	SMAD5	5	10	15	1430.791
#305	PAX7	5	10	15	231.149
#306	E2F3	5	14	19	2442.577
#307	ZFPM1	5	7	12	128.812
#308	REXO4	5	16	21	1901.719
#309	NFYA	5	12	17	1009.855
#310	MTA1	5	9	14	1017.035
#311	DBP	5	10	15	5507.393
#312	DMTF1	5	15	20	1923.133
#313	GTF2H4	5	10	15	8734.051
#314	NR1H2	5	8	13	128.916
#315	GABPA	5	8	13	321.194
#316	CBL	5	10	15	233.543
#317	ZNF215	5	8	13	352.046
#318	TCF15	5	4	9	684.754
#319	MXD1	5	11	16	278.038
#320	HSF1	5	11	16	165.452
#321	PBX2	5	8	13	528.009
#322	BRD8	5	9	14	956.996
#323	ZNF175	5	8	13	957.33
#324	IRX5	5	8	13	1167.459
#325	TCF12	5	11	16	5972.893
#326	HR	5	4	9	100.18
#327	ZNF434	5	9	14	1201.588
#328	FOXD2	5	6	11	118.036
#329	TWIST1	5	9	14	210.805
#330	ZNF446	5	15	20	365.985
#331	FOXD4L5	5	7	12	349.328
#332	RXRB	4	11	15	2786.895
#333	KLF11	4	15	19	1291.347
#334	GATA5	4	7	11	918.727
#335	RAX2	4	8	12	1264.303
#336	IRF9	4	13	17	3845.286
#337	PLSCR1	4	17	21	7433.737
#338	NFIB	4	16	20	1649.167
#339	MLLT10	4	11	15	620.724
#340	PTTG1	4	13	17	2660.163
#341	DLX1	4	11	15	3394.149
#342	HMX2	4	7	11	1446.894
#343	ZNF174	4	11	15	412.311
#344	SREBF1	4	11	15	1862.692
#345	ZNF24	4	10	14	150.458
#346	NFE2L1	4	12	16	1301.043
#347	HOXD10	4	7	11	26.678
#348	PFDN1	4	12	16	4065.813
#349	PLAG1	4	10	14	802.818
#350	RBPJ	4	11	15	138
#351	TFE3	4	9	13	281.792
#352	SUPT4H1	4	13	17	1085.889
#353	ZFHX3	4	10	14	199.882
#354	SCML1	4	12	16	196.796
#355	CIR1	4	12	16	493.276
#356	HOXA9	4	16	20	6865.284
#357	SNAPC2	4	14	18	866.047
#358	DDIT3	4	17	21	534.904
#359	ZSCAN29	4	8	12	866.942
#360	E2F4	4	8	12	369.031
#361	MSRB2	4	10	14	85.056
#362	TEF	4	10	14	1294.43
#363	MAFG	4	16	20	181.929
#364	TBX3	4	6	10	4726.969
#365	SRF	4	12	16	1995.185
#366	VDR	4	8	12	129.68
#367	HMGA2	4	12	16	1489.247
#368	TCF7L1	3	12	15	562.967
#369	JUND	3	11	14	432.59
#370	RORA	3	6	9	242.012
#371	KLF4	3	9	12	3133.326
#372	HOXA11	3	9	12	77.834
#373	STAT5A	3	10	13	238.354
#374	FOSL2	3	12	15	5838.941
#375	YY1	3	8	11	315.669
#376	TULP4	3	12	15	331.927
#377	ZNF91	3	10	13	831.502
#378	PKNOX1	3	12	15	22922.096
#379	NFYC	3	9	12	392.096
#380	MYPOP	3	11	14	194.407
#381	HOXB9	3	6	9	372.842
#382	LHX4	3	11	14	469.262
#383	HOXD1	3	11	14	468.933
#384	FOXC1	3	17	20	1245.878
#385	LCOR	3	11	14	418.683
#386	TRIM22	3	9	12	117.704
#387	JUN	3	7	10	974.524
#388	TWIST2	3	7	10	1489.199
#389	RELB	3	11	14	743.074
#390	NFE2L2	3	15	18	1321.78
#391	TRERF1	3	11	14	75.949
#392	TGIF2	3	12	15	707.785
#393	HOXB7	3	16	19	169.311
#394	LMO4	3	16	19	171.453
#395	NME2	3	10	13	1293.994
#396	STAT2	3	11	14	761.995
#397	ZNF207	3	9	12	179.764
#398	TBX1	3	8	11	465.306
#399	ZNF438	3	12	15	1011.523
#400	RFX5	3	10	13	1645.632
#401	ZNF35	3	10	13	818.742
#402	HMGB2	3	8	11	5232.47
#403	STAT5B	3	12	15	788.232
#404	GTF2IRD1	3	13	16	1884.298
#405	GTF2I	3	9	12	2108.512
#406	SP1	3	9	12	113.299
#407	ARID3A	3	17	20	1694.644
#408	ZNF202	3	14	17	218.327
#409	GABPB1	3	14	17	4832.388
#410	CREB1	3	17	20	1294.788
#411	TEAD3	2	10	12	209.279
#412	WNT5A	2	18	20	690.496
#413	STAT3	2	18	20	7053.022
#414	ZKSCAN3	2	7	9	435.036
#415	RB1	2	9	11	603.295
#416	POU3F2	2	8	10	48.219
#417	NFIX	2	12	14	453.945
#418	GATAD1	2	11	13	66.571
#419	ZNF33B	2	12	14	150.522
#420	TSC22D2	2	18	20	177.014
#421	ARID4A	2	15	17	202.519
#422	ZNF148	2	10	12	228.051
#423	CTCF	2	11	13	122.741
#424	FUBP1	2	11	13	3154.916
#425	ZXDC	2	8	10	374.747
#426	RFXANK	2	7	9	271.948
#427	UBN1	2	10	12	23832.401
#428	ATF6	2	11	13	5109.509
#429	USF2	2	11	13	3022.337
#430	ZBTB17	2	10	12	155.102
#431	TFAP4	2	10	12	1115.226
#432	RARA	2	17	19	3761.919
#433	GRHL3	2	14	16	2226.741
#434	EGR4	2	2	4	464.031
#435	ZSCAN16	2	10	12	878.078
#436	E2F8	2	10	12	245.515
#437	ZNF45	2	11	13	50.277
#438	PURB	2	14	16	252.132
#439	FOXD4L4	2	11	13	151.324
#440	STRN3	2	8	10	41.15
#441	ZNF232	2	10	12	1623.178
#442	SIN3A	2	8	10	723.344
#443	HEYL	2	9	11	208.986
#444	PPARD	2	9	11	203.165
#445	CITED2	2	12	14	164.108
#446	EDF1	1	15	16	144.292
#447	ZRANB2	1	11	12	39.756
#448	FOXD1	1	17	18	1028.89
#449	GTF2H3	1	15	16	884.562
#450	ZNF71	1	12	13	654.233
#451	TAF12	1	13	14	371.114
#452	XBP1	1	17	18	1682.886
#453	POU5F1	1	8	9	323.07
#454	HOXB5	1	11	12	674.744
#455	FOXO3	1	6	7	42.106
#456	MTA2	1	11	12	105.278
#457	AFF4	1	11	12	33.92
#458	ZNF192	1	10	11	186.35
#459	SPEN	1	10	11	41.368
#460	NR2F1	1	13	14	90.994
#461	TFAP2C	1	12	13	2084.231
#462	ELF2	1	11	12	35.292
#463	RCAN1	1	17	18	201.111
#464	ZNF277	1	8	9	561.685
#465	CREBBP	1	16	17	144.173
#466	NCOR1	1	14	15	52.859
#467	TAF10	1	14	15	601.544
#468	SMAD3	1	15	16	39.022
#469	FOXP1	1	10	11	137.379
#470	MTA3	1	12	13	77.502
#471	NFXL1	1	18	19	697.389
#472	NR1D2	1	8	9	14.113
#473	TFCP2	1	10	11	82.849
#474	ATF4	1	15	16	76.714
#475	IRF3	1	15	16	54.353
#476	MNT	1	17	18	59.526
#477	ARNTL	0	7	7	0
#478	TAF13	0	11	11	0
#479	ALX1	0	11	11	0
#480	ADNP2	0	12	12	0
#481	ELF4	0	10	10	0
#482	TEAD4	0	8	8	0
#483	JDP2	0	12	12	0
#484	CLOCK	0	13	13	0
#485	CREBZF	0	9	9	0
#486	MTF1	0	8	8	0
#487	USF1	0	12	12	0
#488	SOX13	0	15	15	0
#489	GATAD2A	0	11	11	0
#490	TCF7L2	0	9	9	0
#491	ZNF444	0	14	14	0
#492	SP4	0	12	12	0
#493	UHRF1	0	12	12	0
#494	NFKB1	0	13	13	0
#495	TAF5L	0	12	12	0
#496	GATAD2B	0	11	11	0
#497	HCFC1	0	14	14	0
#498	SOX7	0	14	14	0
#499	TGIF1	0	9	9	0
#500	RFXAP	0	10	10	0