Hub Rank	Node	Children	Parents	Degree	Betweenness
#1	SPDEF	103	2	105	1028.239
#2	NR1H2	87	4	91	98.601
#3	TCF12	83	3	86	282.051
#4	ZNF207	73	3	76	206.652
#5	AFF4	72	1	73	347.25
#6	GATA3	70	6	76	260.268
#7	REL	59	7	66	130.848
#8	XBP1	57	4	61	479.14
#9	FOXC1	56	4	60	60.995
#10	ZEB1	55	1	56	2651.389
#11	FOXA1	54	2	56	67.325
#12	GTF2H4	53	6	59	369.129
#13	FOXM1	52	6	58	1706.914
#14	DMTF1	52	5	57	225.387
#15	BATF3	49	9	58	484.929
#16	SNAPC2	49	6	55	814.532
#17	ZFP90	49	13	62	6653.834
#18	JDP2	47	12	59	4664.149
#19	CSRNP1	45	9	54	630.52
#20	CREB1	44	12	56	694.284
#21	SMAD4	43	3	46	4626.958
#22	ZNF33A	42	9	51	301.257
#23	NFIL3	42	11	53	2659.962
#24	HIC1	42	8	50	1590.43
#25	GCFC1	42	7	49	1106.319
#26	TFEB	42	12	54	645.31
#27	ESR1	42	9	51	574.861
#28	KLF16	41	12	53	2399.025
#29	RUNX1T1	40	5	45	1040.471
#30	RELA	40	5	45	263.252
#31	TCEAL1	40	7	47	1901.605
#32	TAF4B	40	7	47	268.977
#33	PPARA	40	3	43	2428.075
#34	ZNF444	40	7	47	487.796
#35	TCF4	40	10	50	1874.079
#36	RXRB	40	10	50	505.528
#37	ZNF131	40	6	46	246.036
#38	MYPOP	39	7	46	496.064
#39	TSC22D3	38	9	47	496.976
#40	ESRRA	38	10	48	28691.374
#41	DBP	38	12	50	717.046
#42	RXRA	37	19	56	1856.788
#43	L3MBTL4	37	12	49	1121.917
#44	PHF5A	37	11	48	570.418
#45	PURB	37	15	52	4502.057
#46	GATAD1	36	12	48	2008.609
#47	ZRANB2	36	15	51	1355.118
#48	GAS7	36	10	46	2893.661
#49	CREB3L4	36	12	48	714.028
#50	SNAI2	35	8	43	1817.906
#51	FOXP1	35	11	46	505.286
#52	ZNF91	35	16	51	1070.372
#53	E2F1	35	10	45	2704.255
#54	EN1	34	8	42	527.146
#55	YBX1	34	12	46	3786.685
#56	HCLS1	34	2	36	781.644
#57	ZKSCAN1	34	7	41	290.218
#58	ZBTB38	34	4	38	1190.458
#59	ZNF148	34	8	42	1092.473
#60	ZNF281	33	18	51	1102.162
#61	RELB	33	6	39	610.765
#62	PRRX2	32	16	48	6694.611
#63	MEF2C	32	9	41	1211.702
#64	ELF4	32	13	45	1180.028
#65	E2F3	31	11	42	2314.108
#66	ENO1	31	13	44	2577.815
#67	CBFA2T2	31	3	34	30.58
#68	ZNF83	31	14	45	1762.713
#69	SMAD1	31	4	35	75.128
#70	ZNF446	30	12	42	523.177
#71	RARG	30	15	45	1530.914
#72	AR	30	9	39	583.568
#73	HMG20B	30	14	44	3109.301
#74	ECSIT	29	8	37	3974.163
#75	TSHZ3	29	4	33	836.179
#76	CSDA	28	15	43	543.601
#77	FLI1	28	6	34	1529.141
#78	ZXDC	28	10	38	2862.36
#79	SCAND1	28	7	35	284.321
#80	ZNF71	28	8	36	587.115
#81	RARA	28	9	37	1280.996
#82	GTF2H3	27	6	33	33.753
#83	SLC2A4RG	27	16	43	1161.315
#84	ZNF397	27	13	40	7452.039
#85	MZF1	27	8	35	1132.44
#86	LMO4	26	22	48	1616.987
#87	C2orf3	26	13	39	470.502
#88	IKZF1	26	0	26	0
#89	TCF3	26	12	38	2431.62
#90	ZC3H8	26	10	36	389.882
#91	JUND	26	14	40	873.641
#92	TRIM22	26	8	34	2043.303
#93	EBF1	26	8	34	2315.285
#94	TCF7L1	25	9	34	394.25
#95	C5orf41	25	7	32	1064.045
#96	JUNB	25	14	39	1241.24
#97	SMAD6	25	15	40	588.813
#98	ATF1	25	9	34	433.934
#99	IRF8	24	2	26	5.63
#100	RUNX3	24	10	34	1758.086
#101	NFIX	24	9	33	182.421
#102	ETV7	24	11	35	718.679
#103	MBD1	23	11	34	1830.352
#104	ZHX2	23	8	31	5230.093
#105	MAF	23	9	32	950.406
#106	AEBP1	23	7	30	270.282
#107	NR2F6	22	13	35	675.33
#108	SOX10	22	8	30	123.601
#109	MYNN	22	13	35	561.571
#110	BACH1	22	16	38	1069.905
#111	MYC	22	10	32	1224.732
#112	NOLC1	21	18	39	5381.456
#113	NFYB	21	13	34	3306.389
#114	CNOT8	21	15	36	1037.436
#115	MYBL2	21	8	29	779.493
#116	SALL2	21	11	32	607.967
#117	TEAD2	21	21	42	2014.623
#118	HMGA1	21	15	36	2481.477
#119	RUNX2	21	7	28	2639.922
#120	PTTG1	21	6	27	206.213
#121	CEBPB	21	19	40	553.221
#122	HEYL	21	5	26	1061.322
#123	CDKN2A	20	17	37	1115.848
#124	GTF2I	20	8	28	944.752
#125	MEIS1	20	12	32	1045.995
#126	RBCK1	20	15	35	340.207
#127	CREBL2	20	16	36	773.351
#128	PCGF2	20	23	43	3335.766
#129	PGR	20	20	40	546.806
#130	HDAC2	20	14	34	2395.037
#131	TBX2	20	16	36	2435.219
#132	SP1	20	11	31	651.313
#133	TRIM29	20	18	38	2045.085
#134	SPEN	20	3	23	472.535
#135	GATA2	19	18	37	1040.934
#136	ELF5	19	13	32	1430.896
#137	ELK1	19	14	33	206.113
#138	C1orf85	19	13	32	520.772
#139	FOXN2	19	12	31	3437.002
#140	ATF2	19	8	27	986.892
#141	TCF19	19	14	33	632.172
#142	FOXN3	19	10	29	917.985
#143	CBL	19	15	34	2891.198
#144	MLLT10	19	9	28	553.483
#145	MSX2	18	14	32	1536.624
#146	HOXA9	18	10	28	1279.244
#147	SOX8	18	15	33	630.375
#148	HOXA5	18	7	25	1533.576
#149	CREB3L1	18	12	30	2037.411
#150	FOSL2	18	20	38	7663.187
#151	IRX5	18	20	38	2817.436
#152	ZNF367	18	9	27	482.544
#153	RORA	18	14	32	1869.845
#154	MEIS3P1	18	15	33	621.3
#155	TEF	18	11	29	1292.334
#156	FOXP4	18	21	39	540.001
#157	ERG	18	9	27	1610.687
#158	STAT5B	18	11	29	7348.449
#159	ARNTL2	17	16	33	876.651
#160	BCL3	17	20	37	2307.283
#161	NFIC	17	9	26	331.982
#162	TFEC	17	8	25	721.811
#163	FOXS1	17	14	31	640.459
#164	ZFPM2	17	6	23	197.075
#165	MAX	17	15	32	1280.658
#166	GLI3	17	22	39	1764.441
#167	EPAS1	17	11	28	627.599
#168	SP140	17	7	24	1664.41
#169	PBX1	17	11	28	524.191
#170	TFCP2L1	16	16	32	495.063
#171	SOX12	16	16	32	1517.228
#172	NFYC	16	16	32	1295.691
#173	KLF2	16	19	35	1560.185
#174	MEIS2	16	13	29	763.436
#175	ETV1	16	11	27	315.694
#176	RORC	16	22	38	3535.119
#177	KLF11	16	16	32	492.759
#178	NFIA	16	20	36	854.551
#179	PBX2	16	14	30	281.523
#180	NFE2L3	16	14	30	265.706
#181	ZNF217	15	11	26	984.986
#182	HOXA2	15	11	26	1351.469
#183	ZNF37A	15	17	32	719.803
#184	CBFB	15	14	29	732.612
#185	PITX2	15	15	30	15862.16
#186	IRX1	15	9	24	462.984
#187	NFATC3	15	12	27	5621.212
#188	TAF5	15	17	32	1027.702
#189	TEAD4	14	14	28	892.432
#190	ELF1	14	9	23	315.58
#191	SP3	14	12	26	142.914
#192	SIX5	14	17	31	2709.433
#193	IRF1	14	8	22	1205.082
#194	JUN	14	16	30	1778.693
#195	ANKRD30A	14	15	29	172.864
#196	PRDM1	14	13	27	3274.689
#197	VAV1	14	9	23	1232.436
#198	PURA	14	12	26	603.554
#199	TWIST2	13	14	27	735.704
#200	ZGPAT	13	18	31	2250.644
#201	CSRNP2	13	23	36	2212.216
#202	HOPX	13	23	36	2413.897
#203	ZFP36L2	13	18	31	1856.824
#204	ZNF639	13	15	28	1599.244
#205	BATF2	13	13	26	1619.713
#206	TSHZ2	13	7	20	602.012
#207	ETS2	13	16	29	642.243
#208	SMAD5	13	7	20	205.657
#209	TCF25	13	8	21	686.369
#210	TBX5	13	11	24	1191.299
#211	FUBP1	13	18	31	690.924
#212	CREB3	13	18	31	543.13
#213	MEOX2	13	7	20	880.891
#214	AHCTF1	13	17	30	1083.696
#215	LZTS1	13	16	29	757.338
#216	NR1H3	13	14	27	1496.986
#217	STAT1	12	15	27	1594.603
#218	ATF5	12	14	26	965.056
#219	SCMH1	12	17	29	1345.794
#220	BRD8	12	13	25	616.123
#221	MITF	12	18	30	426.076
#222	HOXB2	12	17	29	4237.402
#223	SATB1	12	25	37	7203.625
#224	CREB3L2	12	19	31	1023.792
#225	UBN1	12	6	18	1509.679
#226	HSF1	12	12	24	275.575
#227	LASS2	12	12	24	356.634
#228	NFXL1	12	14	26	1290.281
#229	TCF7L2	12	16	28	525.765
#230	MMP14	12	10	22	3647.545
#231	ZEB2	12	13	25	3320.841
#232	ZNF202	12	17	29	1516.175
#233	TARDBP	12	13	25	311.755
#234	SPIB	12	17	29	1726.411
#235	TSC22D4	12	12	24	536.576
#236	KDM5B	12	24	36	1084.834
#237	MLL	12	16	28	882.554
#238	ZNF117	11	19	30	1932.087
#239	HOXA7	11	13	24	1215.218
#240	RFXAP	11	15	26	1296.392
#241	ZNF274	11	12	23	129.534
#242	FOXO6	11	20	31	1512.208
#243	MNX1	11	21	32	805.982
#244	TEAD1	11	26	37	2114.594
#245	HOXC13	11	19	30	820.236
#246	BHLHE41	11	24	35	3788.904
#247	MAFG	11	17	28	488.28
#248	TULP4	11	11	22	852.856
#249	SMAD9	11	13	24	754.532
#250	KLF5	11	13	24	493.002
#251	HOXC11	11	13	24	696.635
#252	HOXA3	11	13	24	1160.07
#253	FOXF2	11	5	16	394.632
#254	TFAP2B	11	17	28	966.252
#255	SUPT4H1	11	16	27	826.014
#256	TEAD3	11	16	27	775.308
#257	SREBF2	11	19	30	645.337
#258	VDR	11	21	32	3244.331
#259	SOX6	11	15	26	736.304
#260	ZNF92	11	15	26	1176.762
#261	NFKB2	11	14	25	810.384
#262	RCAN1	11	26	37	1545.896
#263	LEF1	11	24	35	1695.707
#264	IRF4	10	8	18	1067.093
#265	SIN3A	10	17	27	2909.71
#266	FOS	10	9	19	312.866
#267	MYCN	10	21	31	1627.871
#268	ZKSCAN5	10	18	28	565.993
#269	THRB	10	23	33	1174.312
#270	CITED2	10	19	29	1643.148
#271	TBX3	10	16	26	274.141
#272	MGA	10	7	17	378.143
#273	FOSB	10	7	17	1667.177
#274	HR	10	24	34	1266.753
#275	KLF9	10	10	20	416.919
#276	BHLHE40	10	24	34	781.486
#277	ZNF238	10	21	31	1390.855
#278	FOXC2	10	17	27	749.747
#279	NR1D2	10	8	18	295.984
#280	TFDP1	10	22	32	3069.254
#281	CREM	10	16	26	1049.647
#282	NR2F1	10	24	34	1291.583
#283	GABPB1	10	17	27	1185.585
#284	MECOM	10	18	28	935.302
#285	MYT1	10	19	29	2210.689
#286	ESRRG	10	24	34	2075.827
#287	HOXB3	10	16	26	464.786
#288	EOMES	10	7	17	252.782
#289	ZNF138	10	13	23	383.416
#290	ASCL2	9	24	33	736.486
#291	ETS1	9	23	32	847.421
#292	ZNF434	9	19	28	1077.662
#293	BTG2	9	13	22	221.801
#294	ZFHX4	9	14	23	496.625
#295	CEBPD	9	19	28	1707.543
#296	TRERF1	9	18	27	619.744
#297	SIM1	9	13	22	2174.149
#298	ZHX1	9	16	25	820.935
#299	BATF	9	27	36	1014.227
#300	GLIS2	9	11	20	1678.08
#301	MEOX1	9	12	21	386.909
#302	TWIST1	9	22	31	1516.874
#303	ZSCAN16	9	22	31	1750.022
#304	ZIC1	9	12	21	94.274
#305	MAFF	9	22	31	324.949
#306	CTNNB1	9	14	23	392.06
#307	NFAT5	9	5	14	104.965
#308	CEBPA	9	15	24	2235.593
#309	PLSCR1	9	15	24	1113.808
#310	LHX8	9	20	29	33255.215
#311	STAT5A	9	12	21	168.758
#312	TGIF2	9	26	35	623.111
#313	PAX8	9	20	29	169.706
#314	E2F8	9	10	19	838.88
#315	FOXO3	9	18	27	3843.971
#316	ZNF93	9	20	29	407.765
#317	GATAD2B	9	19	28	1306.256
#318	THRA	9	22	31	4849.255
#319	NR2E3	9	18	27	2944.719
#320	EGR3	9	26	35	1969.022
#321	TFDP2	9	21	30	1027.037
#322	CBFA2T3	8	20	28	2047.619
#323	KLF12	8	12	20	998.921
#324	SOX9	8	20	28	1583.01
#325	NFIB	8	22	30	815.589
#326	PRRX1	8	17	25	875.351
#327	FOXQ1	8	21	29	1927.615
#328	FOXJ1	8	15	23	787.212
#329	CREBZF	8	16	24	220.348
#330	NKX2-5	8	21	29	2808.555
#331	STAT4	8	10	18	124.878
#332	TFAP2A	8	12	20	843.938
#333	FOXA3	8	16	24	1574.068
#334	SMAD3	8	14	22	711.673
#335	TAF5L	8	18	26	572.689
#336	NR3C1	8	15	23	1074.392
#337	SIX4	8	21	29	964.732
#338	KLF3	8	13	21	359.633
#339	KDM5A	7	10	17	236.387
#340	IKZF4	7	20	27	489.964
#341	SREBF1	7	24	31	324.661
#342	ETV5	7	21	28	1167.917
#343	GLIS3	7	10	17	741.847
#344	LASS6	7	20	27	368.178
#345	EGR1	7	18	25	2498.109
#346	EGR2	7	18	25	634.218
#347	NR2F2	7	26	33	743.466
#348	NFATC4	7	20	27	607.602
#349	NR3C2	7	13	20	1025.626
#350	SATB2	7	25	32	1791.4
#351	CCRN4L	7	21	28	5629.552
#352	FOXO1	7	22	29	1172.577
#353	TP63	7	15	22	3667.651
#354	IRX3	7	19	26	1618.805
#355	NR2C1	7	26	33	1007.257
#356	BCL6	7	21	28	801.739
#357	ZNF277	7	16	23	282.352
#358	IRF9	7	19	26	705.766
#359	TSHZ1	7	22	29	841.182
#360	AHR	7	20	27	2533.748
#361	KLF6	7	18	25	608.846
#362	HOXC10	7	16	23	2468.823
#363	PBX3	6	28	34	825.755
#364	SOX13	6	14	20	5461.164
#365	MESP2	6	13	19	1670.626
#366	ZNF135	6	19	25	307.343
#367	HMGB2	6	16	22	495.923
#368	TP53	6	19	25	456.148
#369	ZNF33B	6	14	20	991.24
#370	HOXB7	6	18	24	1929.218
#371	UHRF1	6	12	18	431.335
#372	ERF	6	15	21	381.467
#373	HOXA10	6	15	21	6146.664
#374	HMBOX1	6	22	28	464.608
#375	SOX11	6	21	27	2036.068
#376	KLF4	6	21	27	758.925
#377	HOXD8	6	18	24	1354.048
#378	CSRNP3	6	15	21	766.128
#379	TFAM	6	8	14	77.033
#380	OVOL1	6	22	28	2431.121
#381	E2F7	6	14	20	2123.897
#382	HES6	6	18	24	249.603
#383	ONECUT2	6	24	30	2656.9
#384	BCL11B	6	8	14	388.761
#385	HOXD1	6	12	18	433.92
#386	MTA1	6	24	30	741.503
#387	ZNF133	5	24	29	1947.136
#388	SOLH	5	22	27	280.619
#389	ZNF187	5	23	28	1457.719
#390	ELF3	5	24	29	1019.134
#391	TBX1	5	25	30	3486.638
#392	TBX10	5	15	20	265.022
#393	ZIC2	5	24	29	3478.374
#394	PAX6	5	22	27	807.247
#395	PPARG	5	19	24	2050.392
#396	HES1	5	26	31	1880.932
#397	MESP1	5	19	24	539.088
#398	DLX2	5	16	21	264.185
#399	ZFP36L1	5	19	24	772.383
#400	YEATS4	5	25	30	1537.282
#401	NR4A3	5	15	20	1753.484
#402	GATA6	5	23	28	387.253
#403	KLF7	5	15	20	423.238
#404	MSX1	5	16	21	176.884
#405	ARNT2	5	25	30	655.6
#406	ZNF232	5	21	26	323.563
#407	ZSCAN18	5	21	26	1487.878
#408	E2F5	5	19	24	788.537
#409	RUNX1	5	20	25	1101.043
#410	HOXB13	5	25	30	529.041
#411	TGIF1	5	9	14	37.783
#412	ZNF165	5	19	24	333.43
#413	BACH2	5	21	26	561.995
#414	EHF	5	28	33	1016.033
#415	HOXC9	5	19	24	1330.77
#416	PITX1	5	24	29	1688.346
#417	NR4A2	5	22	27	834.445
#418	SUPT6H	5	22	27	2367.228
#419	PEG3	5	33	38	3712.642
#420	ZNF70	4	25	29	862.745
#421	ZFP42	4	9	13	995.86
#422	DLX4	4	20	24	4057.324
#423	ZNF24	4	14	18	163.58
#424	FOXD1	4	22	26	2508.646
#425	IRX4	4	17	21	761.496
#426	NPAS2	4	22	26	2577.968
#427	ZNF498	4	19	23	470.322
#428	NKX3-1	4	30	34	760.276
#429	GTF2H2	4	20	24	372.782
#430	ZNF496	4	31	35	364.425
#431	ATF7	4	22	26	515.88
#432	MYCL1	4	20	24	141.864
#433	ZNF500	4	18	22	148.808
#434	ZNF35	4	27	31	436.314
#435	TRPS1	4	24	28	289.776
#436	ATF3	4	20	24	283.21
#437	ARNT	4	25	29	1619.476
#438	CITED1	4	24	28	840.997
#439	NCOR1	4	20	24	1597.118
#440	SIX2	4	29	33	940.852
#441	SOX2	4	28	32	1005.115
#442	FOXG1	4	15	19	638.752
#443	NFE2L2	4	18	22	161.692
#444	SIX1	4	26	30	1927.631
#445	NFYA	4	20	24	838.951
#446	SOX7	3	22	25	238.974
#447	MXD1	3	26	29	854.84
#448	DLX1	3	18	21	746.246
#449	IRF5	3	20	23	276.214
#450	HEY1	3	21	24	1804.127
#451	IRF7	3	11	14	189.266
#452	TSC22D1	3	19	22	521.425
#453	SOX15	3	20	23	1379.779
#454	WT1	3	30	33	4687.738
#455	CTBP1	3	28	31	4202.22
#456	FOXK2	3	25	28	807.68
#457	MKX	3	26	29	5516.775
#458	ATF6	3	18	21	3799.44
#459	HOXB6	3	13	16	438.94
#460	MEIS3	3	18	21	656.33
#461	C12orf28	3	26	29	1907.28
#462	IRX2	3	29	32	1189.71
#463	ZNF174	3	13	16	17.576
#464	TFCP2	3	16	19	49.659
#465	BLZF1	3	21	24	790.767
#466	GRHL3	3	14	17	604.589
#467	ZNF323	3	29	32	831.771
#468	PAX7	2	13	15	364.205
#469	POU2F3	2	19	21	273.064
#470	ZNF140	2	17	19	46.449
#471	FOXP2	2	18	20	208.768
#472	IRF6	2	34	36	401.74
#473	ARX	2	27	29	1534.046
#474	ZFHX3	2	25	27	120.594
#475	HLF	2	14	16	193.152
#476	NFATC2	2	14	16	137.081
#477	ETV6	2	18	20	204.334
#478	TFAP2C	2	26	28	446.252
#479	SLC26A3	2	24	26	1337.525
#480	NANOG	2	22	24	134.122
#481	CUX2	2	12	14	588.288
#482	WNT5A	2	22	24	101.301
#483	ASCL1	2	25	27	239.226
#484	LHX6	2	25	27	649.989
#485	SOX4	2	20	22	79.769
#486	HEY2	2	31	33	1225.386
#487	FOXI1	2	30	32	595.895
#488	SIX3	2	17	19	303.388
#489	HHEX	2	25	27	803.382
#490	NR4A1	2	19	21	218.7
#491	STAT6	1	13	14	9.198
#492	CNOT7	1	23	24	17.57
#493	NFATC1	1	20	21	28.576
#494	ZNF268	1	19	20	48.452
#495	MSRB2	0	22	22	0
#496	SLC30A9	0	25	25	0
#497	SCML1	0	22	22	0
#498	CREB5	0	24	24	0
#499	SIM2	0	31	31	0
#500	HOXB5	0	12	12	0