Hub Rank	Node	Children	Parents	Degree	Betweenness
#1	ZEB2	43	2	45	12902.931
#2	ATF2	38	9	47	13909.359
#3	IKZF3	38	2	40	46.837
#4	ETS1	38	3	41	7220.755
#5	NKX2-4	37	3	40	122.302
#6	GSX2	36	5	41	229.151
#7	GRHL2	35	3	38	551.425
#8	FLI1	35	3	38	8210.595
#9	PRRX1	35	6	41	279.38
#10	TRIM29	33	6	39	1263.277
#11	KLF5	33	4	37	226.99
#12	ZEB1	32	3	35	81.067
#13	HLF	32	6	38	474.58
#14	ZNF187	32	6	38	2491.404
#15	KLF3	32	3	35	162.771
#16	SP4	32	8	40	317.289
#17	TCF4	31	4	35	211.395
#18	ZNF189	31	8	39	2298.846
#19	MLL	31	7	38	1240.541
#20	SP140	31	3	34	179.594
#21	UNCX	31	1	32	43.953
#22	HMGA1	30	10	40	942.386
#23	HCLS1	29	0	29	0
#24	GRHL3	28	7	35	1802.6
#25	IRX3	28	6	34	1535.15
#26	PBX1	28	5	33	1411.846
#27	GATAD2A	27	8	35	2531.028
#28	NKX3-1	26	4	30	653.537
#29	EBF1	26	3	29	46.445
#30	LASS2	26	7	33	660.575
#31	RUNX1T1	26	4	30	13362.37
#32	KLF12	26	6	32	633.609
#33	C5orf41	26	8	34	1510.627
#34	TP63	26	7	33	822.16
#35	BLZF1	26	10	36	2567.799
#36	JUNB	26	12	38	2551.813
#37	ZNF197	25	8	33	2994.682
#38	HOPX	25	10	35	17150.872
#39	ARID4A	25	11	36	2710.418
#40	PLSCR1	25	10	35	1924.998
#41	ALS2CR8	25	11	36	3840.524
#42	STAT4	25	3	28	2418.595
#43	NFIX	25	10	35	1314.695
#44	AHR	24	10	34	1027.181
#45	ZNF438	24	9	33	1245.785
#46	NFKB1	24	9	33	1486.539
#47	ZNF287	23	10	33	3047.479
#48	TFEC	23	8	31	1998.163
#49	SIX2	23	6	29	244.808
#50	NFATC2	23	10	33	1190.187
#51	NR2F6	23	8	31	534.549
#52	ZNF449	23	10	33	1241.155
#53	FOXN2	23	12	35	1794.129
#54	IRF8	23	5	28	2005.373
#55	ZNF192	23	11	34	1257.986
#56	EHF	22	11	33	1862.477
#57	TGIF1	22	12	34	1714.001
#58	C2orf3	22	10	32	1660.244
#59	NR2C1	22	10	32	854.542
#60	MXD1	22	8	30	413.181
#61	ZHX3	22	13	35	1407.997
#62	MYC	22	8	30	552.515
#63	ZFP36L1	21	9	30	1052.991
#64	DMTF1	21	3	24	168.159
#65	AEBP1	21	6	27	15405.422
#66	NFE2L2	21	6	27	1131.672
#67	ZNF131	21	16	37	3365.456
#68	SREBF2	20	8	28	1599.332
#69	MYNN	20	4	24	1213.022
#70	PPARD	20	10	30	1268.861
#71	BNC1	20	16	36	5576.627
#72	ZNF33B	20	8	28	1248.195
#73	ELF1	20	9	29	2982.439
#74	HIF1A	20	10	30	6501.091
#75	TFDP2	20	10	30	2572.591
#76	FOSL2	19	8	27	288.369
#77	TFAP2A	19	5	24	229.064
#78	TCF12	19	8	27	1324.461
#79	RUNX2	19	13	32	1223.667
#80	RXRA	19	9	28	930.282
#81	ETV6	19	9	28	800.163
#82	RARG	19	7	26	359.089
#83	TLX2	19	5	24	824.375
#84	FUBP1	19	9	28	773.967
#85	ZNF175	19	10	29	2226.679
#86	NPAT	19	8	27	913.133
#87	GATAD2B	18	8	26	706.95
#88	ZNF24	18	14	32	3864.946
#89	HOXB7	18	6	24	864.011
#90	TWIST2	18	10	28	814.044
#91	NFATC4	18	7	25	680.486
#92	MEOX2	18	4	22	14580.381
#93	CREBBP	18	7	25	977.413
#94	MTF1	18	13	31	2915.375
#95	STAT1	18	5	23	127.412
#96	SOX5	18	13	31	3471.551
#97	DLX4	18	7	25	167.519
#98	ZNF277	18	6	24	3182.228
#99	CREM	18	12	30	2158.885
#100	RORA	17	13	30	1415.532
#101	PRDM2	17	12	29	1384.052
#102	SOX2	17	12	29	1043.827
#103	DBP	17	8	25	708.701
#104	AFF1	17	7	24	353.019
#105	ZBTB38	17	11	28	2967.633
#106	ERG	17	9	26	15517.799
#107	NR2F1	17	16	33	1488.279
#108	HCFC1	17	4	21	294.547
#109	RB1	17	10	27	2541.297
#110	TAF10	17	10	27	1005.4
#111	GABPB1	17	13	30	6696.451
#112	FOXN3	17	10	27	3580.122
#113	NR2F2	17	4	21	14187.088
#114	IRF2	16	9	25	267.012
#115	NCOR1	16	5	21	264.613
#116	MEF2C	16	5	21	115.749
#117	ZNF148	16	8	24	930.837
#118	STRN3	16	13	29	1601.042
#119	ZNF83	16	18	34	4436.325
#120	FOXM1	16	7	23	1953.239
#121	PURB	16	10	26	2542.479
#122	ZSCAN16	16	9	25	2042.648
#123	TFAP2C	16	15	31	716.58
#124	RFX5	16	7	23	356.289
#125	TRIM22	16	7	23	137.993
#126	TCEAL1	16	11	27	2606.448
#127	STAT5B	16	12	28	2415.925
#128	PKNOX1	16	8	24	1797.482
#129	IRF1	15	7	22	71.711
#130	CCRN4L	15	9	24	738.715
#131	TCF15	15	5	20	343.311
#132	GBX2	15	7	22	200.472
#133	SOX21	15	11	26	1079.517
#134	RBPJ	15	12	27	2575.939
#135	HOXD11	15	5	20	851.22
#136	THRB	15	10	25	1666.511
#137	MITF	15	9	24	758.987
#138	SOX1	15	10	25	914.873
#139	VAV1	15	7	22	247.915
#140	HEY2	15	14	29	2513.259
#141	MTA3	15	17	32	1088.535
#142	HDX	15	9	24	1238.601
#143	AFF4	15	11	26	2823.628
#144	TCF20	15	7	22	383.426
#145	FOXK2	15	18	33	1675.16
#146	SOX7	15	9	24	1209.994
#147	SPEN	15	8	23	606.774
#148	ZNF140	14	14	28	2290.727
#149	RUNX1	14	12	26	781.439
#150	CEBPB	14	15	29	2681.966
#151	TSHZ2	14	12	26	2789.749
#152	IRF4	14	12	26	493.268
#153	MBD1	14	11	25	1632.844
#154	PHTF1	14	11	25	483.269
#155	MEIS1	14	14	28	2282.287
#156	CREB5	14	12	26	2590.029
#157	OVOL1	14	13	27	1138.577
#158	NR3C2	14	12	26	1304.61
#159	SRF	14	14	28	3241.539
#160	AHCTF1	14	8	22	5150.189
#161	TBP	14	11	25	1741.279
#162	STAT5A	14	7	21	661.268
#163	SATB1	14	19	33	10173.814
#164	IKZF1	14	5	19	226.952
#165	NOLC1	13	9	22	1312.281
#166	TSHZ3	13	8	21	190.643
#167	RELA	13	10	23	1594.625
#168	CREBL2	13	7	20	85.082
#169	NFIL3	13	15	28	4757.895
#170	HMGB2	13	14	27	2238.927
#171	DLX3	13	12	25	1601.846
#172	MYBL2	13	8	21	1112.241
#173	TCF7L2	13	10	23	2077.394
#174	GTF2H3	13	17	30	3352.596
#175	NR1H3	13	8	21	1413.628
#176	TRPS1	13	15	28	2733.942
#177	HES1	13	7	20	534.354
#178	FOSL1	13	9	22	739.2
#179	PCGF6	13	11	24	1491.181
#180	HOXC9	13	9	22	3163.72
#181	BTAF1	13	9	22	1832.119
#182	BHLHE40	13	13	26	1709.788
#183	KLF4	13	7	20	370.724
#184	ARNTL2	13	11	24	2315.707
#185	FOXP2	13	14	27	1852.263
#186	GCFC1	13	10	23	1496.402
#187	GATA3	12	11	23	1651.816
#188	PHF1	12	7	19	1102.234
#189	STAT2	12	7	19	58.484
#190	MTA2	12	14	26	1098.353
#191	ELF3	12	8	20	584.266
#192	MLLT10	12	9	21	1641.02
#193	ZNF639	12	11	23	1323.549
#194	CBL	12	9	21	255.309
#195	AATF	12	14	26	3981.846
#196	NR5A2	12	9	21	245.24
#197	HOXC10	12	9	21	1618.405
#198	BATF	12	5	17	220.869
#199	GTF2IRD1	12	13	25	1457.66
#200	RCOR1	11	10	21	385.847
#201	HOXD10	11	7	18	2151.666
#202	NFIB	11	11	22	1978.183
#203	ETV1	11	13	24	3141.013
#204	ZNF483	11	14	25	1391.731
#205	ZNF165	11	13	24	1654.304
#206	KLF7	11	14	25	1977.675
#207	RFX3	11	11	22	1410.702
#208	HMBOX1	11	15	26	1256.648
#209	SNAPC5	11	17	28	1086.238
#210	POU2F3	11	12	23	413.565
#211	PFDN1	11	19	30	5627.894
#212	CLOCK	11	13	24	3006.31
#213	ZNF45	11	12	23	1214.636
#214	ENO1	11	9	20	1114.132
#215	NR3C1	11	13	24	1900.758
#216	GLIS3	11	9	20	754.284
#217	GABPA	11	7	18	379.899
#218	ZNF193	11	15	26	1727.67
#219	HOXD9	11	7	18	379.99
#220	SMAD4	11	19	30	1282.811
#221	ZXDA	11	15	26	1943.737
#222	BRD8	11	15	26	2230.837
#223	SUPT6H	10	10	20	1576.123
#224	ZFP90	10	13	23	808.576
#225	E2F8	10	16	26	2105.686
#226	AR	10	12	22	451.193
#227	PHF5A	10	13	23	3479.041
#228	BATF2	10	8	18	1110.742
#229	ELK3	10	16	26	1119.307
#230	PTTG1	10	12	22	3464.445
#231	NFIA	10	17	27	1985.023
#232	ZNF91	10	14	24	2218.655
#233	ZNF3	10	16	26	1490.133
#234	LHX8	10	8	18	727.925
#235	WNT5A	10	13	23	1769.361
#236	IRF6	10	14	24	1289.945
#237	CREBZF	10	12	22	2699.726
#238	LASS6	10	13	23	1052.554
#239	ZBTB25	10	10	20	313.329
#240	E2F3	10	8	18	765.539
#241	NFE2L1	10	17	27	4462.141
#242	SIN3A	10	11	21	407.144
#243	NFYB	10	15	25	1672.689
#244	MEIS2	10	15	25	1365.585
#245	STAT6	9	16	25	1557.791
#246	SMAD3	9	17	26	1636.567
#247	HEY1	9	14	23	1613.367
#248	DRAP1	9	8	17	825.766
#249	L3MBTL4	9	14	23	819.009
#250	ADNP2	9	15	24	2828.988
#251	ZNF281	9	11	20	407.423
#252	FOXA2	9	7	16	1234.994
#253	LEF1	9	9	18	87.697
#254	ATF7	9	12	21	413.099
#255	TLX1	9	10	19	621.393
#256	EGR3	9	8	17	963.723
#257	TSC22D2	9	7	16	2368.88
#258	HOXC13	9	13	22	979.147
#259	ARNTL	9	16	25	2248.934
#260	CIR1	9	11	20	1040.958
#261	PCGF2	9	16	25	1281.295
#262	FOXQ1	9	12	21	810.402
#263	MECOM	9	18	27	2343.28
#264	NFE2L3	9	9	18	950.158
#265	ETS2	9	18	27	3454.935
#266	ZNF238	9	13	22	1120.272
#267	TEAD2	9	10	19	1148.864
#268	TRIM25	9	14	23	837.403
#269	ZNF33A	9	11	20	1551.646
#270	IRF9	9	7	16	74.153
#271	DLX6	9	14	23	1234.694
#272	LASS5	9	10	19	532.044
#273	HMGB1	9	12	21	1076.589
#274	CNOT8	8	15	23	647.574
#275	STAT3	8	14	22	1134.137
#276	ZNF37A	8	10	18	398.043
#277	HNRNPAB	8	16	24	1035.649
#278	MAX	8	14	22	2441.489
#279	NR1D2	8	11	19	2492.641
#280	SIX4	8	11	19	406.344
#281	PLAGL2	8	12	20	215.793
#282	REL	8	11	19	527.021
#283	MAFB	8	16	24	1979.533
#284	BACH2	8	11	19	1663.092
#285	TSC22D3	8	12	20	606.592
#286	ZNF92	8	17	25	1414.121
#287	YEATS4	8	14	22	1254.324
#288	HSF2	8	19	27	1915.359
#289	HOXB6	8	11	19	910.944
#290	ATF3	8	9	17	412.908
#291	TADA2A	8	11	19	1554.451
#292	HOXA5	8	14	22	2076.853
#293	ELF2	8	17	25	1061.304
#294	RXRB	8	13	21	1734.77
#295	CSDA	8	13	21	441.28
#296	CSRNP3	8	18	26	1117.469
#297	FOXP1	8	11	19	1421.878
#298	EPAS1	8	14	22	1752.397
#299	SLC30A9	8	16	24	3168.25
#300	BHLHE41	8	23	31	9962.606
#301	PITX1	8	12	20	898.39
#302	ZFPM2	8	8	16	1674.64
#303	ZNF75D	8	9	17	253.814
#304	FOSB	8	5	13	778.337
#305	FOXO3	8	13	21	622.668
#306	FBXW7	8	18	26	1375.551
#307	LCOR	8	12	20	1248.084
#308	TAF12	8	13	21	804.154
#309	FOXA1	7	13	20	1139.187
#310	ZNF256	7	14	21	3104.243
#311	TFDP1	7	12	19	259.969
#312	ZC3H8	7	10	17	1179.162
#313	MSRB2	7	13	20	2787.138
#314	SCML2	7	17	24	2699.984
#315	MAF	7	17	24	906.492
#316	MYCL1	7	13	20	3371.415
#317	FOXN1	7	8	15	315.538
#318	ATF1	7	10	17	329.267
#319	SNAI2	7	13	20	907.609
#320	TSC22D1	7	14	21	2787.051
#321	ETV7	7	9	16	525.049
#322	ZNF445	7	11	18	657.16
#323	NFX1	7	15	22	2332.444
#324	NR4A2	7	13	20	1493.256
#325	CITED2	7	11	18	813.959
#326	ZFP37	7	13	20	361.966
#327	TEAD1	7	15	22	1247.894
#328	CUX1	7	11	18	499.77
#329	MMP14	7	9	16	370.546
#330	ZNF80	7	6	13	1679.895
#331	PGBD1	7	14	21	523.674
#332	GSC2	7	15	22	1588.976
#333	CREB3	7	14	21	1636.535
#334	NR2E1	7	14	21	1937.832
#335	TCFL5	7	11	18	323.43
#336	CTNNB1	7	14	21	2122.169
#337	SCML1	7	20	27	1323.915
#338	ZNF154	7	11	18	219.864
#339	HOXA7	7	17	24	718.011
#340	HESX1	7	15	22	1336.973
#341	E2F7	7	11	18	1418.243
#342	TAF5	7	17	24	2197.956
#343	SATB2	7	22	29	2059.972
#344	SOX15	7	9	16	344.316
#345	TFAM	7	13	20	2757.171
#346	ZNF90	6	9	15	681.272
#347	EGR2	6	13	19	4466.977
#348	TAF4B	6	17	23	1006.127
#349	GTF2I	6	10	16	963.964
#350	MSC	6	15	21	314.886
#351	BACH1	6	17	23	916.152
#352	ZHX2	6	16	22	2634.743
#353	HDAC1	6	9	15	270.501
#354	SMAD5	6	17	23	1281.886
#355	GAS7	6	12	18	428.552
#356	CDKN2A	6	14	20	913.993
#357	ZNF232	6	15	21	1581.377
#358	FOXE1	6	13	19	353.104
#359	MGA	6	17	23	1515.416
#360	KLF11	6	14	20	554.532
#361	ZNF135	6	12	18	685.96
#362	ZNF138	6	10	16	742.93
#363	PAX5	6	8	14	515.944
#364	ZSCAN29	6	17	23	1116.977
#365	ZNF81	6	11	17	324.555
#366	NFAT5	6	12	18	956.69
#367	ZNF217	6	14	20	918.521
#368	NPAS2	6	14	20	132.785
#369	SOX6	6	13	19	1178.845
#370	TRERF1	6	14	20	1946.775
#371	MSX2	6	16	22	2434.315
#372	TAF5L	6	14	20	898.373
#373	ETV5	6	22	28	3762.22
#374	ETV4	6	9	15	664.379
#375	EGR1	6	15	21	2945.813
#376	RFXAP	6	12	18	685.025
#377	BATF3	6	12	18	339.933
#378	ZNF323	6	14	20	500.742
#379	RCAN1	6	12	18	1177.737
#380	ASCL1	5	11	16	1574.951
#381	KDM5A	5	12	17	211.302
#382	TEF	5	11	16	528.672
#383	CSRNP2	5	14	19	813.962
#384	SIX3	5	11	16	678.431
#385	CREB3L2	5	16	21	835.794
#386	ZNF396	5	11	16	1676.828
#387	ZNF394	5	12	17	691.276
#388	SCMH1	5	13	18	467.655
#389	TFCP2L1	5	8	13	1071.856
#390	TAF1B	5	16	21	2578.938
#391	FOS	5	8	13	1337.262
#392	HOXB2	5	8	13	419.84
#393	ELF4	5	14	19	447.659
#394	E2F5	5	15	20	826.755
#395	HHEX	5	10	15	117.156
#396	FOXD3	5	14	19	521.72
#397	ZNF93	5	19	24	1200.439
#398	PAX6	5	11	16	1043.75
#399	ZNF35	5	19	24	691.291
#400	NANOG	5	15	20	1759.6
#401	ATF4	5	12	17	274.302
#402	TFAP2B	5	17	22	1179.144
#403	POU6F2	5	14	19	871.404
#404	NFE2	5	9	14	1236.211
#405	HOXD8	5	12	17	1443.374
#406	NR4A3	5	10	15	625.697
#407	HOXA1	5	11	16	351.39
#408	MYF6	5	8	13	766.494
#409	NFXL1	5	12	17	526.794
#410	UHRF1	5	12	17	1109.769
#411	ZNF117	5	16	21	932.696
#412	SMAD1	5	15	20	1253.674
#413	CBFA2T2	5	15	20	1509.21
#414	PPARG	5	18	23	885.474
#415	KDM5B	5	12	17	257.023
#416	C1orf85	5	16	21	2260.578
#417	ZNF397	4	10	14	316.573
#418	TBX3	4	10	14	144.67
#419	HOXA9	4	11	15	615.738
#420	SMAD2	4	14	18	1515.388
#421	TSHZ1	4	14	18	870.385
#422	RORB	4	13	17	1026.447
#423	HMGA2	4	18	22	676.29
#424	PBX2	4	16	20	1741.362
#425	TCF19	4	12	16	412.662
#426	ZSCAN12	4	16	20	1190.022
#427	TLX3	4	13	17	420.173
#428	FOXD1	4	16	20	302.843
#429	XBP1	4	11	15	103.704
#430	TP53	4	17	21	1548.713
#431	ZNF643	4	16	20	348.406
#432	PLAG1	4	15	19	1385.117
#433	TBX15	4	11	15	782.926
#434	ESRRG	4	7	11	243.267
#435	GLI3	4	13	17	888.726
#436	ADNP	4	15	19	373.959
#437	ZKSCAN5	4	10	14	183.052
#438	HAND2	4	14	18	554.82
#439	MEF2A	4	12	16	503.414
#440	ZSCAN5B	3	12	15	538.243
#441	ZNF215	3	20	23	617.265
#442	MAFG	3	14	17	764.709
#443	SIX1	3	19	22	397.631
#444	USF1	3	10	13	469.35
#445	ZKSCAN1	3	14	17	729.456
#446	TBX19	3	15	18	1124.241
#447	SCAND3	3	12	15	560.93
#448	ETV3	3	15	18	1260.115
#449	LMO4	3	16	19	763.337
#450	KCNH8	3	11	14	879.425
#451	PRDM1	3	17	20	569.897
#452	SIM2	3	14	17	1517.729
#453	KLF10	3	21	24	416.95
#454	SRY	3	24	27	517.203
#455	ZKSCAN3	3	16	19	180.894
#456	HOXA2	3	14	17	707.706
#457	EOMES	3	6	9	214.739
#458	PAX3	3	10	13	336.996
#459	E2F6	3	24	27	1798.258
#460	KLF6	3	19	22	1456.168
#461	CSRNP1	3	11	14	324.347
#462	ZNF85	3	14	17	656.038
#463	SOX30	2	13	15	871.354
#464	C12orf28	2	17	19	893.537
#465	ZNF155	2	14	16	755.436
#466	POU5F1B	2	11	13	1736.242
#467	NR6A1	2	12	14	230.97
#468	ISL1	2	10	12	92.672
#469	PROX1	2	16	18	206.733
#470	REXO4	2	13	15	565.991
#471	BCL6	2	16	18	1235.221
#472	PAX8	2	11	13	233.885
#473	RXRG	2	11	13	897.911
#474	ASCL2	2	14	16	618.671
#475	JUN	2	17	19	611.285
#476	DDIT3	2	12	14	333.541
#477	ZNF167	2	15	17	361.947
#478	NR0B1	2	12	14	336.246
#479	SALL2	1	12	13	35.536
#480	MLXIPL	1	16	17	1313.509
#481	ZNF174	1	12	13	121.041
#482	TAF7	1	15	16	35.397
#483	NR1H4	1	17	18	606.881
#484	ELF5	1	19	20	400.483
#485	PBX3	1	11	12	115.148
#486	BTG2	1	12	13	65.076
#487	ZNF69	1	13	14	215.601
#488	ZIC1	1	18	19	314.799
#489	CNOT7	1	11	12	423.948
#490	SPIC	1	11	12	113.76
#491	NR1I3	1	17	18	67.377
#492	TPRX1	1	13	14	89.929
#493	MEOX1	1	8	9	26.626
#494	HOXA4	1	6	7	105.097
#495	ZFHX4	0	19	19	0
#496	MKX	0	15	15	0
#497	MEIS3	0	12	12	0
#498	RHOXF1	0	10	10	0
#499	ALX1	0	14	14	0
#500	TMEM229A	0	13	13	0