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Hub Rank	Node	Children	Parents	Degree	Betweenness
#1	NR3C1	61	7	68	1100.806
#2	ZEB1	58	1	59	872.472
#3	ZHX2	55	9	64	1112.106
#4	HSF2	53	6	59	892.945
#5	KLF5	53	11	64	1079.508
#6	ELK3	53	2	55	67.4
#7	MEIS1	48	9	57	2258.676
#8	TWIST1	46	8	54	1995.657
#9	SALL2	44	10	54	1218.298
#10	HMG20B	43	9	52	1605.735
#11	CDKN2A	42	12	54	4160.917
#12	PCGF2	42	6	48	1515.5
#13	ARNTL2	41	8	49	1450.476
#14	NFIB	41	12	53	1609.62
#15	NR1D2	40	12	52	2097.28
#16	PLSCR1	40	7	47	1068.076
#17	SMAD3	39	11	50	2151.461
#18	TFAP2A	38	11	49	4998.286
#19	ZFHX3	37	10	47	828.579
#20	PAX8	37	19	56	4104.5
#21	AHR	37	8	45	500.618
#22	MTA2	37	5	42	410.221
#23	HOXB7	36	9	45	668.718
#24	SOX12	36	6	42	217.698
#25	ETV1	35	10	45	1153.239
#26	JUN	35	10	45	1285.632
#27	RELA	35	7	42	1149.768
#28	MLL	34	10	44	1045.624
#29	ETS1	33	4	37	504.586
#30	RUNX1	33	14	47	800.605
#31	IRF6	33	7	40	263.188
#32	STRN3	32	6	38	262.158
#33	ETS2	32	9	41	493.276
#34	SATB2	32	10	42	2808.932
#35	TAF12	32	12	44	1348.919
#36	HMG20A	32	12	44	1241.113
#37	MEIS2	32	20	52	6077.972
#38	ZNF217	31	11	42	1137.228
#39	HOXB6	31	6	37	703.972
#40	HOXC10	31	13	44	1233.809
#41	FOXD1	31	12	43	1535.027
#42	ELF3	31	7	38	369.62
#43	BHLHE41	31	13	44	2891.788
#44	MECOM	31	17	48	1820.026
#45	HOXB5	31	6	37	375.776
#46	ZEB2	31	4	35	612.501
#47	EPAS1	30	9	39	570.844
#48	NFE2L3	30	14	44	1442.649
#49	LZTR1	30	8	38	1128.445
#50	SIX1	30	8	38	714.432
#51	TRIM29	30	9	39	553.296
#52	GRHL2	29	1	30	6.393
#53	PFDN1	29	7	36	632.048
#54	ZBTB38	29	12	41	511.87
#55	HMGA2	29	15	44	3148.534
#56	CREBZF	29	12	41	744.301
#57	DLX2	28	21	49	2160.719
#58	SMAD6	28	14	42	1470.481
#59	TCF3	28	9	37	497.544
#60	TCF4	28	17	45	2106.444
#61	MAX	28	11	39	1167.577
#62	FLI1	28	7	35	807.667
#63	PURA	28	9	37	734.098
#64	RB1	28	16	44	3822.492
#65	CBFA2T2	28	14	42	2752.238
#66	TFAP2C	27	12	39	993.67
#67	HOXC11	27	9	36	908.833
#68	ZNF643	27	15	42	1584.46
#69	NFIL3	27	10	37	886.92
#70	LMO4	27	11	38	842.207
#71	ZXDC	27	15	42	1430.528
#72	POU5F1B	27	6	33	333.575
#73	ZNF140	26	6	32	571.487
#74	TCF12	26	13	39	731.074
#75	HEY1	26	14	40	862.8
#76	CNOT7	26	12	38	2084.367
#77	CNOT8	26	4	30	504.557
#78	CREM	26	11	37	1353.523
#79	PBX3	25	8	33	373.281
#80	NR2F6	25	15	40	2357.359
#81	KLF4	24	16	40	1324.28
#82	MITF	24	12	36	1151.115
#83	TAF10	24	18	42	1636.265
#84	ZNF148	24	13	37	1415.297
#85	SIX2	23	11	34	955.986
#86	JUNB	23	14	37	1602.685
#87	NFATC3	23	10	33	2907.042
#88	E2F1	23	10	33	958.294
#89	MEF2C	23	10	33	1102.973
#90	ZNF133	23	11	34	1486.458
#91	CSDA	23	12	35	1443.733
#92	BACH2	22	6	28	932.463
#93	IRF5	22	15	37	1932.571
#94	YY1	22	10	32	1494.564
#95	TBX2	22	7	29	269.536
#96	CREBBP	22	16	38	2337.756
#97	ZNF91	22	7	29	701.531
#98	TRPS1	22	16	38	1006.032
#99	KLF12	22	9	31	924.754
#100	POU2F1	22	9	31	767.889
#101	ARNT	22	12	34	287.73
#102	PKNOX1	22	15	37	1213.229
#103	ZKSCAN5	21	10	31	859.584
#104	TAF4	21	19	40	2756.147
#105	TARDBP	21	9	30	782.376
#106	HOXC13	21	10	31	958.906
#107	ZNF33B	21	9	30	1109.674
#108	VDR	21	10	31	437.609
#109	CBFB	21	8	29	955.401
#110	CTBP1	21	17	38	1934.572
#111	E2F5	20	15	35	1732.179
#112	SALL1	20	5	25	159.558
#113	GLI3	20	17	37	2087.813
#114	TCF25	20	18	38	1558.493
#115	EDF1	20	16	36	1860.927
#116	NFE2L1	20	14	34	2500.712
#117	MEF2A	20	12	32	816.844
#118	FOXA2	20	6	26	478.405
#119	HOXA10	20	12	32	1544.942
#120	FOXN3	20	12	32	984.368
#121	HOXA1	20	18	38	2421.009
#122	ARID3A	20	14	34	1791.055
#123	RXRA	20	12	32	2348.385
#124	HOXB2	20	14	34	1597.934
#125	SRF	20	11	31	358.251
#126	SOX2	20	13	33	1485.309
#127	SPEN	20	12	32	1153.708
#128	KDM5B	19	17	36	735.88
#129	PA2G4	19	10	29	1147.178
#130	HES1	19	14	33	1001.66
#131	GATAD1	19	13	32	1531.063
#132	RCOR1	19	10	29	1306.297
#133	FOSL1	19	9	28	454.723
#134	TAF6	19	13	32	587.697
#135	SOX9	19	19	38	972.222
#136	HDAC1	19	9	28	417.364
#137	SIM2	19	22	41	1907.348
#138	DMTF1	19	9	28	854.682
#139	KLF6	18	20	38	1841.501
#140	ZSCAN5A	18	16	34	2777.976
#141	ZNF236	18	14	32	734.278
#142	C2orf3	18	10	28	954.084
#143	PHF1	18	10	28	700.71
#144	SIX3	18	19	37	1755.746
#145	E4F1	18	10	28	723.548
#146	PRDM2	18	15	33	1455.177
#147	MSX1	18	17	35	1154.931
#148	ZNF444	18	13	31	1388.508
#149	PLAGL2	18	12	30	1221.802
#150	ZNF24	18	14	32	1042.91
#151	LHX2	18	14	32	1486.646
#152	TEAD4	18	11	29	1082.841
#153	NCOR1	17	10	27	483.558
#154	ZNF434	17	12	29	662.129
#155	CEBPA	17	13	30	1738.465
#156	GATA6	17	18	35	2078.044
#157	NR5A2	17	10	27	800.858
#158	HOXC4	17	16	33	2966.997
#159	AFF4	17	10	27	759.248
#160	ZNF93	17	16	33	669.939
#161	ZSCAN18	17	18	35	884.812
#162	CREB1	17	13	30	1464.492
#163	NR2F1	17	20	37	1247.056
#164	STAT2	17	14	31	1471.575
#165	E2F3	17	16	33	1484.252
#166	ENO1	17	10	27	797.362
#167	ZFP36L2	17	18	35	2473.785
#168	AEBP1	16	10	26	614.398
#169	ESR1	16	14	30	1195.639
#170	KLF2	16	10	26	707.921
#171	TCFL5	16	16	32	1153.397
#172	HOXA11	16	11	27	508.234
#173	GATA2	16	13	29	2493.334
#174	PITX1	16	19	35	2022.111
#175	MBD1	16	10	26	833.211
#176	MLLT10	16	17	33	839.995
#177	GTF2I	16	10	26	749.574
#178	NFIC	16	18	34	1718.081
#179	CREB3L1	16	16	32	1344.278
#180	TFDP1	16	11	27	958.39
#181	ZNF189	16	20	36	1206.859
#182	ATF2	16	12	28	1102.552
#183	CLOCK	16	14	30	1789.161
#184	BUD31	16	12	28	1737.829
#185	MGA	16	21	37	1504.517
#186	NR1H3	16	18	34	2163.666
#187	GATAD2A	15	19	34	1734.218
#188	PPARG	15	13	28	891.64
#189	TRIM22	15	17	32	2377.319
#190	MAFG	15	14	29	1320.173
#191	FUBP1	15	12	27	778.73
#192	XBP1	15	11	26	398.117
#193	DRAP1	15	10	25	590.607
#194	MYCN	15	9	24	425.157
#195	VTN	15	10	25	656.952
#196	ZNF165	15	16	31	772.018
#197	POU1F1	15	4	19	263.536
#198	MNT	15	15	30	603.162
#199	ZNF174	15	12	27	947.002
#200	ETV4	15	16	31	2389.135
#201	SOX17	15	22	37	1963.604
#202	TFAM	15	16	31	1455.084
#203	HOXB9	15	8	23	371.377
#204	AHCTF1	15	17	32	1118.429
#205	TP53	15	19	34	2865.075
#206	RERE	15	13	28	673.508
#207	ZKSCAN1	15	10	25	868.902
#208	ZNF268	14	14	28	1180.82
#209	GTF2H4	14	15	29	1477.984
#210	FOXE1	14	21	35	2122.824
#211	TP63	14	5	19	492.584
#212	FOXA1	14	15	29	1624.275
#213	PBX2	14	12	26	367.593
#214	ZNF323	14	12	26	306.302
#215	ADNP	14	15	29	1967.239
#216	RFX5	14	18	32	374.801
#217	DBP	14	19	33	898.635
#218	NFX1	14	15	29	853.399
#219	HOXA9	14	13	27	611.023
#220	TCF20	14	10	24	396.681
#221	ELF4	14	11	25	772.804
#222	MEOX2	14	7	21	1084.66
#223	PBX1	14	15	29	2101.784
#224	IRX4	14	6	20	193.941
#225	ZNF202	14	15	29	1442.893
#226	NR2F2	14	23	37	1986.32
#227	PHTF1	14	15	29	584.637
#228	HR	14	5	19	144.762
#229	GBX2	13	17	30	1421.297
#230	ECSIT	13	14	27	1405.164
#231	SUPT6H	13	16	29	966.055
#232	CEBPD	13	15	28	1060.172
#233	MTA1	13	14	27	500.632
#234	HOXD4	13	11	24	1171.106
#235	CREB3L2	13	23	36	1596.74
#236	HHEX	13	29	42	2775.451
#237	TGIF1	13	14	27	593.762
#238	CSRNP2	13	9	22	420.153
#239	HOXA7	13	9	22	634.763
#240	MYC	13	12	25	767.482
#241	STAT3	13	13	26	439.73
#242	ZNF274	13	13	26	997.402
#243	LASS2	13	17	30	1257.424
#244	AFF1	13	19	32	1267.724
#245	ESRRG	13	8	21	389.576
#246	TSC22D1	13	18	31	3732.374
#247	MYNN	13	13	26	760.928
#248	HMBOX1	12	13	25	986.029
#249	RCAN1	12	16	28	1341.758
#250	NFKB2	12	16	28	1550.459
#251	BLZF1	12	11	23	303.391
#252	MTF1	12	14	26	1257.367
#253	RARG	12	20	32	1054.153
#254	MSL3	12	17	29	1013.742
#255	IRF1	12	16	28	1086.492
#256	CEBPB	12	17	29	1331.833
#257	SCML1	12	14	26	594.069
#258	ZBTB48	12	9	21	528.767
#259	LHX6	12	15	27	639.967
#260	WT1	12	11	23	758.186
#261	CUX1	12	16	28	830.366
#262	ZNF193	12	11	23	655.219
#263	RBCK1	12	12	24	892.312
#264	RARB	12	12	24	889.169
#265	BHLHE40	12	14	26	636.392
#266	C11orf9	12	18	30	1140.24
#267	TEAD1	11	19	30	2201.598
#268	CREBL2	11	21	32	2262.297
#269	ZNF500	11	11	22	283.157
#270	ZIC1	11	19	30	1242.537
#271	KLF10	11	11	22	469.355
#272	ETV5	11	12	23	381.036
#273	ZNF83	11	22	33	1682.524
#274	NR4A2	11	17	28	1633.58
#275	MSRB2	11	14	25	386.165
#276	ZNF175	11	12	23	1392.549
#277	LZTS1	11	12	23	740.87
#278	ZNF215	11	17	28	1580.448
#279	JUND	11	14	25	626.757
#280	ADNP2	11	17	28	853.822
#281	BACH1	11	13	24	499.763
#282	CITED1	11	16	27	960.758
#283	MEOX1	11	20	31	2522.635
#284	ERG	11	5	16	198.13
#285	ZNF167	11	14	25	621.257
#286	ZNF45	11	19	30	2974.828
#287	MAFF	11	16	27	867.263
#288	KLF7	11	19	30	979.466
#289	CSRNP3	11	10	21	839.917
#290	MEIS3P1	11	18	29	569.536
#291	SOX4	11	21	32	1515.558
#292	IRX5	11	15	26	1497.453
#293	HMGA1	10	14	24	857.584
#294	ERF	10	12	22	404.414
#295	NKX3-1	10	13	23	405.286
#296	TBX3	10	14	24	561.606
#297	GABPA	10	9	19	607.512
#298	TADA3	10	19	29	1165.49
#299	SMAD1	10	24	34	1577.35
#300	SUPT4H1	10	18	28	1311.758
#301	EHF	10	13	23	538.824
#302	TFDP2	10	20	30	2039.715
#303	TFCP2	10	26	36	1276.944
#304	STAT6	10	16	26	1334.184
#305	ZIC3	10	5	15	96.204
#306	ZNF281	10	13	23	750.371
#307	ZNF277	10	18	28	953.363
#308	ELF1	10	16	26	846.307
#309	SOX5	10	7	17	187.335
#310	RNF4	10	20	30	2303.872
#311	ZNF263	10	14	24	1344.74
#312	FOXF1	10	6	16	152.823
#313	HOXD3	10	6	16	512.841
#314	SCAND1	10	15	25	706.706
#315	TBX1	10	17	27	572.124
#316	NR2C1	9	18	27	681.97
#317	RBPJ	9	25	34	2062.62
#318	HOXA4	9	11	20	1223.006
#319	SMAD2	9	19	28	2008.799
#320	UBN1	9	16	25	580.17
#321	SREBF1	9	17	26	719.187
#322	TCF7L2	9	20	29	1032.033
#323	FOXM1	9	19	28	993.925
#324	ZNF232	9	21	30	1496.101
#325	FOXL2	9	22	31	1056.815
#326	E2F8	9	17	26	514.388
#327	IRF7	9	17	26	730.045
#328	ONECUT2	9	7	16	485.575
#329	GCFC1	9	17	26	624.491
#330	SCML2	9	24	33	485.068
#331	SMAD4	9	17	26	1493.031
#332	NFKB1	9	20	29	1211.366
#333	ZNF3	9	10	19	347.096
#334	RELB	9	16	25	1035.893
#335	RUNX1T1	9	8	17	483.445
#336	HCLS1	9	21	30	1197.515
#337	FBXW7	9	17	26	476.237
#338	KDM5A	9	17	26	652.428
#339	HIF1A	9	17	26	480.078
#340	BATF3	9	16	25	570.688
#341	ZNF135	9	12	21	1034.76
#342	LASS6	9	16	25	989.955
#343	ZNF394	9	13	22	893.245
#344	GTF2IRD1	8	23	31	984.167
#345	RFXANK	8	23	31	870.832
#346	NFAT5	8	13	21	411.347
#347	MZF1	8	16	24	1314.191
#348	HOXD1	8	14	22	586.949
#349	ISL1	8	19	27	1319.806
#350	MLX	8	17	25	1208.218
#351	TAF7	8	14	22	650.509
#352	ELK4	8	15	23	953.64
#353	TCEAL1	8	14	22	576.077
#354	TSC22D3	8	22	30	1758.337
#355	HSF1	8	18	26	1373.703
#356	CREB3	8	19	27	591.394
#357	NANOG	8	12	20	186.268
#358	NR4A3	8	23	31	868.208
#359	HOXA5	8	12	20	1127.841
#360	MSX2	8	20	28	2069.891
#361	SOX11	8	18	26	460.094
#362	FOXK2	8	16	24	461.353
#363	SCMH1	8	15	23	606.059
#364	NFYB	8	20	28	1657.246
#365	TAF1B	8	21	29	718.417
#366	NFYC	8	20	28	735.402
#367	ARNTL	7	18	25	960.974
#368	TCF7	7	23	30	578.946
#369	POU4F1	7	18	25	556.762
#370	VAV1	7	18	25	282.669
#371	RARA	7	18	25	844.938
#372	ZFHX4	7	26	33	1542.108
#373	GABPB1	7	19	26	1210.266
#374	ZFP37	7	17	24	329.21
#375	REL	7	14	21	428.626
#376	ZFP36L1	7	22	29	2357.044
#377	BCL3	7	19	26	1241.344
#378	NFE2L2	7	13	20	243.435
#379	IRF9	7	15	22	440.172
#380	FOSL2	7	23	30	792.942
#381	BCL11B	7	13	20	679.881
#382	HNF1B	7	18	25	650.502
#383	BARX1	7	13	20	556.814
#384	SREBF2	6	17	23	500.806
#385	SNAI2	6	29	35	1096.234
#386	MMP14	6	16	22	705.549
#387	RUNX3	6	23	29	1645.493
#388	PITX2	6	14	20	733.717
#389	NOTCH1	6	20	26	1349.094
#390	SOX13	6	15	21	387.94
#391	FOXO3	6	22	28	519.838
#392	NFYA	6	19	25	414.356
#393	TCF7L1	6	22	28	578.051
#394	ALX1	6	13	19	729.547
#395	CITED2	6	29	35	1571.957
#396	PLAG1	6	18	24	496.188
#397	EGR3	6	12	18	243.949
#398	REXO4	6	19	25	741.467
#399	TEAD3	6	26	32	1009.484
#400	NKX2-5	6	14	20	819.389
#401	FOXF2	6	24	30	1424.313
#402	PRRX2	6	15	21	655.185
#403	STAT4	6	15	21	381.69
#404	ZFPM2	6	15	21	295.649
#405	HOXD9	6	8	14	410.236
#406	NPAS2	6	22	28	1027.458
#407	ESRRA	6	15	21	439.663
#408	ZNF131	6	16	22	883.999
#409	FOXG1	6	21	27	678.69
#410	KLF3	6	20	26	466.348
#411	TFE3	6	20	26	1074.063
#412	SIM1	6	4	10	162.036
#413	NR1H4	6	7	13	115.982
#414	ZNF155	6	19	25	468.96
#415	HIRA	5	17	22	291.621
#416	SMAD5	5	18	23	785.784
#417	ZNF117	5	18	23	1047.865
#418	NFATC1	5	15	20	505.425
#419	SPDEF	5	18	23	895.627
#420	PAX6	5	25	30	805.424
#421	TULP4	5	19	24	931.212
#422	BNC1	5	17	22	591.843
#423	TGIF2	5	27	32	1373.305
#424	PTTG1	5	21	26	452.475
#425	ATF3	5	24	29	554.983
#426	ARNT2	5	16	21	592.095
#427	STAT1	5	20	25	1488.968
#428	KLF9	5	22	27	608.35
#429	FOXJ3	5	17	22	317.836
#430	DLX4	5	19	24	965.08
#431	ZNF187	5	9	14	196.913
#432	IRF2	5	18	23	726.124
#433	NPAT	5	19	24	611.953
#434	BATF	5	9	14	162.837
#435	ZHX3	5	14	19	162.986
#436	ARID4A	5	21	26	811.027
#437	ZSCAN16	5	22	27	821.606
#438	NOLC1	5	18	23	955.871
#439	CREB5	5	18	23	429.457
#440	ETV6	5	10	15	198.411
#441	WNT5A	5	23	28	972.663
#442	YEATS4	5	21	26	744.791
#443	ATF6	4	24	28	617.699
#444	ZBTB25	4	19	23	600.601
#445	SOX15	4	22	26	704.966
#446	TSC22D2	4	24	28	708.254
#447	HEY2	4	9	13	409.111
#448	TFDP3	4	13	17	371.763
#449	HOXB3	4	10	14	99.379
#450	ZGPAT	4	24	28	587.561
#451	ZNF238	4	22	26	348.268
#452	NR3C2	4	18	22	217.635
#453	MYBL2	4	19	23	374.209
#454	HOPX	4	15	19	196.137
#455	SNAPC5	4	22	26	1324.777
#456	NR2E1	4	15	19	316.874
#457	IRF3	4	21	25	342.728
#458	ZNF35	4	21	25	1735.349
#459	NR2C2	4	22	26	451.854
#460	PEG3	4	16	20	512.228
#461	MAFB	4	21	25	449.3
#462	HOXA2	3	12	15	247.22
#463	BTAF1	3	17	20	435.628
#464	ATF5	3	18	21	101.122
#465	ZNF85	3	12	15	146.103
#466	ATF1	3	18	21	257.276
#467	ZNF134	3	17	20	606.501
#468	LEF1	3	14	17	374.583
#469	BCL6	3	23	26	634.685
#470	PPARD	3	13	16	445.381
#471	DDIT3	3	20	23	443.643
#472	GATA3	3	25	28	846.641
#473	ZBTB17	3	19	22	522.738
#474	TAF13	3	18	21	902.445
#475	LHX1	2	17	19	256.111
#476	TAF4B	2	23	25	191.073
#477	IRF8	2	14	16	509.191
#478	SATB1	2	27	29	601.26
#479	CBFA2T3	2	13	15	128.296
#480	FOXC1	2	22	24	289.614
#481	SNAPC4	2	18	20	188.522
#482	MAF	2	15	17	226.699
#483	MYCL1	2	19	21	494.909
#484	BTG2	2	24	26	661.166
#485	ZSCAN12	2	15	17	175.83
#486	STAT5B	2	23	25	211.714
#487	MNX1	2	21	23	645.293
#488	SLC2A4RG	1	19	20	586.406
#489	FOXO1	1	23	24	58.142
#490	TFAP2B	1	10	11	37.281
#491	NR0B1	1	11	12	16.018
#492	TAF5	1	24	25	384.505
#493	FOS	1	17	18	725.878
#494	EGR1	1	22	23	51.013
#495	GLI2	1	21	22	105.227
#496	AATF	1	17	18	1042.72
#497	TFEC	1	9	10	29.687
#498	KLF11	1	23	24	757.787
#499	GAS7	1	20	21	135.879
#500	FOXJ2	1	16	17	82.709