Hub Rank	Node	Children	Parents	Degree	Betweenness
#1	SUPT6H	125	1	126	20.565
#2	TFCP2	88	9	97	6004.127
#3	TBX2	88	2	90	1061.363
#4	ZNF483	87	2	89	911.736
#5	ZNF3	86	6	92	230.751
#6	NOTCH1	80	4	84	2874.574
#7	NFATC2	75	11	86	897.329
#8	SPEN	74	4	78	624.992
#9	NFYA	71	6	77	359.904
#10	RARA	71	6	77	157.784
#11	GABPA	71	5	76	1378.076
#12	MSX2	70	4	74	526.703
#13	ZNF81	69	5	74	70.056
#14	NR2E3	67	6	73	103.535
#15	GTF2H4	66	11	77	7353.498
#16	SOX1	65	10	75	1065.402
#17	ZBTB48	64	8	72	10289.664
#18	PCGF2	64	8	72	157.551
#19	RELA	64	2	66	42.26
#20	CREB1	64	8	72	2152.482
#21	KDM5A	62	13	75	3448.978
#22	AFF4	61	12	73	1200.814
#23	ATF7	61	4	65	141.955
#24	ST18	61	7	68	646.178
#25	SP3	60	11	71	820.96
#26	ISL2	60	4	64	919.547
#27	TBX1	59	6	65	302.454
#28	TCF3	59	0	59	0
#29	ZNF445	59	3	62	174.614
#30	SOX15	58	8	66	373.931
#31	HCFC1	58	10	68	3127.423
#32	MYBL2	57	21	78	3291.244
#33	FOXO1	57	4	61	92.34
#34	MZF1	56	9	65	846.799
#35	TADA2A	56	21	77	845.918
#36	HOXC9	55	7	62	175.209
#37	IKZF1	55	5	60	1154.235
#38	HMG20B	53	12	65	449.423
#39	RUNX3	52	12	64	579.195
#40	TCF7L1	52	12	64	3561.037
#41	POU2F2	52	10	62	1302.746
#42	MAX	52	8	60	159.428
#43	DLX4	52	13	65	669.758
#44	RXRB	52	4	56	1187.422
#45	TSHZ3	51	14	65	1642.971
#46	HMGA1	50	10	60	354.753
#47	NR2F6	50	11	61	1329.881
#48	ELF1	48	14	62	499.535
#49	GTF2H3	48	13	61	1663.647
#50	GATA2	46	8	54	445.427
#51	CBFA2T2	45	12	57	1201.926
#52	NPAT	45	11	56	6881.262
#53	TLX3	45	16	61	1288.873
#54	RORC	45	11	56	549.713
#55	ARID4A	45	20	65	3108.73
#56	MLLT10	44	18	62	1597.604
#57	TRIM29	44	19	63	1906.953
#58	EGR4	44	20	64	550.054
#59	HSF1	44	8	52	3794.639
#60	MLL	43	10	53	178.455
#61	ZNF18	43	13	56	1508.915
#62	TBX5	43	17	60	918.946
#63	TAL1	43	13	56	514.018
#64	ZNF75D	42	11	53	391.734
#65	SIX5	41	19	60	1017.687
#66	MEIS3	41	9	50	4103.596
#67	PBX2	41	10	51	437.214
#68	TFAP2C	41	6	47	875.068
#69	MYF5	41	16	57	551.214
#70	ZNF219	40	11	51	513.156
#71	JUND	40	3	43	520.813
#72	NPAS1	40	18	58	342.143
#73	KLF3	40	12	52	585.046
#74	CREB3L3	39	11	50	186.339
#75	MAFG	39	6	45	414.897
#76	STAT3	38	15	53	772.563
#77	NFE2L2	38	16	54	573.062
#78	SMAD5	38	9	47	132.049
#79	CDKN2A	37	24	61	3324.967
#80	BCL3	37	13	50	499.427
#81	ARNTL	37	12	49	3309.142
#82	ZEB2	37	7	44	916.963
#83	TEAD1	37	7	44	839.017
#84	ZFP90	37	13	50	300.339
#85	SREBF1	36	26	62	1861.339
#86	KLF16	36	8	44	946.544
#87	HIF1A	35	13	48	1409.686
#88	SCAND1	35	16	51	287.426
#89	RUNX1	34	17	51	624.339
#90	NPAS2	34	20	54	3185.015
#91	ZNF93	34	17	51	1422.4
#92	TFE3	34	11	45	934.008
#93	TP53	33	11	44	419.267
#94	ZNF193	33	17	50	1551.817
#95	MYC	33	14	47	1407.173
#96	NFKB2	33	17	50	345.75
#97	MAF	32	9	41	1956.573
#98	BHLHE41	32	13	45	255.121
#99	SPIB	31	15	46	968.919
#100	ETV6	31	14	45	440.62
#101	ONECUT2	31	23	54	1027.304
#102	ATF6	31	17	48	1437.807
#103	PHF1	31	11	42	634.831
#104	HOXB7	31	5	36	685.478
#105	TRPS1	31	13	44	912.206
#106	POU6F1	30	14	44	771.209
#107	ZNF45	30	15	45	7207.203
#108	KLF4	30	12	42	1239.897
#109	ATOH1	30	19	49	865.58
#110	FOXK1	30	26	56	1389.645
#111	ELF5	30	15	45	1075.177
#112	ZNF169	30	23	53	4832.929
#113	GLI3	30	16	46	250.685
#114	ZNF197	30	19	49	675.392
#115	TP63	29	18	47	2244.657
#116	CEBPD	29	6	35	404.137
#117	ZNF41	29	13	42	444.928
#118	SPIC	29	8	37	2550.134
#119	ZFP36L2	29	7	36	243.831
#120	PHTF1	28	21	49	3821.635
#121	RERE	28	15	43	194.866
#122	BHLHE40	28	9	37	1413.863
#123	BTG2	28	9	37	229.503
#124	STAT2	28	15	43	250.857
#125	ZNF131	28	9	37	261.564
#126	ELK1	28	13	41	1471.988
#127	NFATC4	28	15	43	2238.119
#128	CUX1	28	16	44	247.987
#129	PBX1	28	5	33	181.593
#130	PKNOX2	27	15	42	1289.406
#131	VSX1	27	16	43	795.166
#132	C1orf85	27	17	44	1181.427
#133	C2orf3	27	17	44	7790.136
#134	CREM	27	19	46	276.452
#135	ZXDC	26	10	36	2453.12
#136	ZNF117	26	23	49	2068.49
#137	SOX5	26	21	47	1011.84
#138	AHCTF1	26	18	44	1143.563
#139	AEBP1	26	15	41	401.054
#140	MEIS2	26	10	36	969.065
#141	E2F2	26	15	41	929.008
#142	SMAD6	26	12	38	149.438
#143	KLF9	26	9	35	1662.511
#144	HOXD1	25	26	51	2244.677
#145	TFDP1	25	16	41	446.036
#146	HOXA5	25	5	30	568.386
#147	IRF4	25	22	47	667.65
#148	ESRRG	25	15	40	754.487
#149	ISL1	25	27	52	1948.249
#150	HOXD4	24	17	41	611.489
#151	NKX2-8	24	19	43	703.944
#152	MESP1	24	25	49	1636.858
#153	HEY2	24	11	35	706.027
#154	TCF4	24	19	43	1894.285
#155	HHEX	24	16	40	1404.249
#156	RAX2	24	20	44	1607.621
#157	TCF12	24	10	34	1554.943
#158	RARB	24	17	41	562.71
#159	UHRF1	24	15	39	3998.431
#160	FOXM1	23	10	33	261.445
#161	JUNB	23	4	27	238.596
#162	ZNF71	23	17	40	226.194
#163	RB1	23	23	46	1017.601
#164	MSRB2	23	18	41	340.319
#165	WT1	23	15	38	967.751
#166	NFE2L3	23	7	30	874.815
#167	SMAD1	23	12	35	866.168
#168	ENO1	22	20	42	1100.986
#169	ATF6B	22	18	40	323.353
#170	TSC22D3	22	12	34	140.052
#171	BCL6	22	19	41	1370.215
#172	ZNF446	22	24	46	817.105
#173	PURB	22	17	39	770.844
#174	IRF5	22	16	38	408.352
#175	FOXS1	22	22	44	701.032
#176	ASCL1	22	22	44	4065.359
#177	MNX1	22	24	46	799.849
#178	TULP4	22	14	36	1493.904
#179	POU6F2	21	18	39	1575.807
#180	MNT	21	19	40	1155.584
#181	SNAPC5	21	22	43	450.905
#182	FOS	21	6	27	319.502
#183	LASS6	21	15	36	759.948
#184	ZNF215	21	18	39	1470.531
#185	HOXB2	20	27	47	4335.693
#186	STAT1	20	23	43	2025.357
#187	ZNF83	20	20	40	1582.015
#188	YY1	20	20	40	355.08
#189	ONECUT3	20	26	46	1629.971
#190	ZNF287	20	11	31	4897.072
#191	JUN	20	19	39	939.834
#192	POU3F1	20	18	38	444.483
#193	ZSCAN12	20	21	41	781.582
#194	ZNF643	19	25	44	1516.755
#195	SMAD4	19	15	34	1339.475
#196	ETS1	19	19	38	858.269
#197	PBX3	19	24	43	505.927
#198	TCF21	19	26	45	2721.783
#199	TLX2	19	20	39	1527.565
#200	FOXH1	19	20	39	527.388
#201	FOXP1	19	23	42	700.843
#202	SPI1	19	15	34	120.54
#203	TWIST1	19	22	41	3020.261
#204	ZSCAN18	19	11	30	640.186
#205	BATF	19	24	43	1312.073
#206	HIF3A	19	33	52	2097.611
#207	RCOR1	19	19	38	345.875
#208	DMBX1	18	24	42	802.182
#209	GATA4	18	32	50	4184.662
#210	ZNF438	18	15	33	878.233
#211	BACH2	18	27	45	1613.734
#212	SLC2A4RG	18	19	37	309.837
#213	SIX4	18	26	44	1184.823
#214	KLF2	18	18	36	515.431
#215	HESX1	18	25	43	1694.724
#216	TRIM22	18	19	37	1165.72
#217	ZSCAN23	18	19	37	11454.422
#218	NR4A2	18	12	30	398.383
#219	PGBD1	18	16	34	1085.157
#220	ZNF202	18	20	38	972.616
#221	MMP14	18	17	35	1108.314
#222	ELF4	18	24	42	803.285
#223	NR4A3	17	22	39	2035.866
#224	MAFB	17	5	22	300.82
#225	AHR	17	20	37	533.26
#226	HOXA7	17	12	29	509.621
#227	FOXO3	17	16	33	3123.424
#228	KLF6	17	11	28	334.6
#229	TCFL5	17	11	28	758.572
#230	HOXD13	17	18	35	2225.078
#231	ZIC1	17	22	39	1401.812
#232	NFE2	17	18	35	744.044
#233	GAS7	17	25	42	798.223
#234	DLX6	17	22	39	669.051
#235	MYT1	17	23	40	2108.033
#236	KLF5	17	22	39	2562.087
#237	GATAD2B	17	23	40	1537.62
#238	NR2F2	16	25	41	2927.186
#239	SOX4	16	12	28	617.551
#240	ZFPM2	16	23	39	1188.353
#241	NFIC	16	17	33	240.992
#242	FOXL1	16	20	36	3241.303
#243	TFAP2A	16	22	38	1066.439
#244	TCF7L2	16	20	36	1083.235
#245	HNF4G	16	16	32	731.974
#246	MEF2D	16	21	37	1370.451
#247	FOXP2	16	25	41	809.256
#248	HES6	16	20	36	1152.896
#249	ZSCAN20	16	19	35	1597.259
#250	PLAG1	16	19	35	1707.715
#251	ZSCAN1	15	25	40	1607.616
#252	ZNF157	15	17	32	311.402
#253	ZNF449	15	24	39	402.145
#254	GATA6	15	21	36	316.029
#255	SMAD3	15	26	41	1257.078
#256	HES1	15	31	46	1560.353
#257	LEF1	15	24	39	1065.425
#258	TCF20	15	29	44	4482.806
#259	C11orf9	15	26	41	779.476
#260	TSC22D1	15	19	34	959.426
#261	FOXL2	15	18	33	3400.552
#262	ESR2	15	16	31	221.288
#263	RUNX2	15	20	35	734.982
#264	ZBTB38	15	20	35	316.726
#265	PROX1	15	24	39	772.308
#266	NANOGNB	15	25	40	958.602
#267	ARNT	15	17	32	220.823
#268	PPARA	15	21	36	784.154
#269	PPARD	15	24	39	2031.097
#270	TRERF1	15	21	36	542.914
#271	ZNF434	14	18	32	399.105
#272	ZIC2	14	22	36	824.166
#273	NR2F1	14	28	42	966.584
#274	BUD31	14	17	31	1436.807
#275	SOX21	14	21	35	179.775
#276	BNC1	14	27	41	472.779
#277	MBD1	14	27	41	684.461
#278	SOX30	14	24	38	1218.353
#279	ZNF396	14	17	31	1227.591
#280	MLXIPL	14	15	29	976.008
#281	CTBP1	14	23	37	871.324
#282	HMGB2	14	33	47	2533.844
#283	MKX	14	16	30	1489.307
#284	NFIX	13	28	41	1212.86
#285	NKX6-2	13	27	40	1370.524
#286	POU4F1	13	24	37	1242.442
#287	ATF5	13	22	35	872.507
#288	SOX9	13	29	42	820.989
#289	ZNF132	13	31	44	1289.608
#290	NR1H3	13	21	34	722.489
#291	TSC22D2	13	23	36	423.446
#292	NFATC1	13	23	36	1010.437
#293	ZFHX3	13	20	33	1163.882
#294	FOSL1	13	23	36	488.607
#295	KLF15	13	24	37	1069.955
#296	THRA	13	21	34	1600.306
#297	FOSB	13	8	21	836.373
#298	GCFC1	13	24	37	1165.305
#299	PKNOX1	13	23	36	884.106
#300	ZNF165	13	22	35	1190.701
#301	IRF6	13	26	39	1466.59
#302	MYNN	12	29	41	1614.759
#303	EBF1	12	20	32	818.381
#304	RORA	12	21	33	655.608
#305	GLIS3	12	22	34	1581.556
#306	SATB1	12	20	32	525.473
#307	TGIF1	12	30	42	1870.251
#308	SOX6	12	17	29	318.52
#309	IRX1	12	20	32	3148.153
#310	TAF13	12	29	41	6409.55
#311	HOXD9	12	22	34	804.628
#312	NR3C2	12	29	41	716.903
#313	ZSCAN10	12	30	42	3400.64
#314	IRX3	12	30	42	1850.715
#315	SIX1	12	26	38	1556.933
#316	OTX2	12	28	40	421.344
#317	ZNF256	12	17	29	220.367
#318	ZNF238	12	26	38	527.341
#319	ISX	12	22	34	236.86
#320	EPAS1	12	27	39	787.447
#321	SALL2	11	31	42	1575.94
#322	ZNF85	11	30	41	805.422
#323	NR4A1	11	10	21	126.471
#324	ELF3	11	20	31	772.857
#325	BATF2	11	23	34	699.717
#326	ATF3	11	24	35	1001.037
#327	BACH1	11	33	44	662.782
#328	T	11	26	37	1533.081
#329	HOXA13	11	23	34	331.732
#330	POU2F3	11	19	30	770.976
#331	PPARG	11	16	27	1089.403
#332	TBX3	11	31	42	1879.101
#333	FOXD3	11	31	42	872.601
#334	HOXA10	11	14	25	1698.852
#335	OLIG2	10	22	32	767.986
#336	SOX2	10	29	39	797.895
#337	MECOM	10	25	35	1066.097
#338	AR	10	25	35	1279.553
#339	ZNF91	10	27	37	439.493
#340	NR6A1	10	26	36	379.032
#341	TFEC	10	26	36	1454.111
#342	IRX5	10	31	41	1357.213
#343	TAF1B	10	20	30	377.901
#344	POU3F4	10	37	47	2246.566
#345	SMAD9	10	29	39	645.06
#346	BLZF1	10	34	44	2919.755
#347	HOXA1	10	20	30	503.179
#348	CSDA	10	20	30	546
#349	STAT5B	10	23	33	429.066
#350	FOXA3	10	31	41	2899.245
#351	EGR3	10	21	31	1361.783
#352	BATF3	10	22	32	347.13
#353	HNF4A	9	32	41	3927.235
#354	FOXO4	9	32	41	226.673
#355	PITX1	9	18	27	431.068
#356	ZNF496	9	33	42	742.527
#357	IRX4	9	32	41	1358.363
#358	ZNF397	9	38	47	677.605
#359	FOXC2	9	26	35	1499.901
#360	FOXA1	9	28	37	1022.84
#361	ZNF24	9	26	35	605.919
#362	NEUROD1	9	31	40	389.566
#363	TBX19	9	30	39	1469.688
#364	PITX2	9	31	40	940.777
#365	ARNT2	9	24	33	477.289
#366	CSRNP3	9	29	38	674.855
#367	FOXC1	9	29	38	1129.291
#368	SIX2	9	29	38	2349.052
#369	EGR1	9	10	19	1017.992
#370	HOXB8	9	29	38	2933.267
#371	FOXK2	8	26	34	948.041
#372	ETS2	8	19	27	412.62
#373	POU1F1	8	32	40	1746.738
#374	SOX11	8	30	38	1377.298
#375	ALX3	8	35	43	8419.251
#376	ZFP36L1	8	33	41	982.707
#377	ZNF92	8	24	32	368.723
#378	MAFF	8	25	33	369.622
#379	ZNF19	8	31	39	989.637
#380	POU3F2	8	21	29	219.983
#381	KLF12	8	24	32	529.255
#382	ZSCAN2	8	27	35	545.93
#383	MEOX2	8	30	38	1134.395
#384	NR1H4	8	22	30	368.592
#385	SCAND2	8	37	45	1213.959
#386	ATF2	8	28	36	1655.449
#387	GLI2	8	33	41	1392.443
#388	ESRRB	8	28	36	891.57
#389	DMRT2	8	32	40	503.615
#390	TFDP2	8	22	30	366.627
#391	RCOR2	8	27	35	714.597
#392	PRRX1	8	24	32	855.692
#393	LMO4	8	34	42	648.871
#394	GSX1	7	29	36	472.162
#395	PBX4	7	27	34	1041.743
#396	HOXA4	7	24	31	685.132
#397	LHX1	7	28	35	669.981
#398	PAX3	7	37	44	2082.338
#399	PGR	7	19	26	226.825
#400	SOX18	7	29	36	331.969
#401	ESX1	7	36	43	1852.049
#402	ETV5	7	26	33	804.426
#403	CREBZF	7	30	37	460.208
#404	ELK4	7	30	37	312.419
#405	ZNF148	7	18	25	119.166
#406	ZNF639	7	25	32	510.378
#407	ERG	7	34	41	430.044
#408	PEG3	7	41	48	801.326
#409	NFIA	7	36	43	705.758
#410	HES5	7	22	29	602.219
#411	RCAN1	7	30	37	651.36
#412	SP140	7	27	34	1177.67
#413	HOXD3	7	27	34	585.724
#414	CUX2	7	28	35	753.955
#415	NKX3-2	7	21	28	538.097
#416	FOXD1	7	26	33	616.265
#417	SLC26A3	7	30	37	731.98
#418	LHX8	7	21	28	624.762
#419	LHX2	6	25	31	927.34
#420	LMX1B	6	26	32	282.875
#421	WNT5A	6	38	44	847.671
#422	HOXA9	6	16	22	910.341
#423	SIM1	6	28	34	2846.81
#424	REL	6	39	45	798.98
#425	TEAD2	6	30	36	647.273
#426	THRB	6	30	36	5957.562
#427	TP73	6	29	35	735.285
#428	PAX6	6	29	35	1358.549
#429	NFAT5	6	39	45	2140.642
#430	TFAP2B	6	30	36	799.439
#431	MGA	6	37	43	937.977
#432	ZSCAN4	6	28	34	223.463
#433	HLF	6	40	46	979.299
#434	KLF17	6	29	35	460.917
#435	FOXE1	6	29	35	1718.158
#436	SOX7	6	30	36	174.936
#437	HEY1	6	29	35	1728.356
#438	EGR2	6	19	25	704.874
#439	BCL11B	6	20	26	283.847
#440	POU2F1	5	38	43	1029.381
#441	PAX8	5	39	44	1003.569
#442	TBX22	5	32	37	1463.416
#443	NFYC	5	30	35	892.636
#444	ZNF207	5	29	34	349.868
#445	TEF	5	40	45	898.59
#446	BARX1	5	29	34	642.355
#447	NFIB	5	39	44	501.763
#448	CREB5	5	35	40	618.211
#449	ZFP42	5	30	35	394.928
#450	FOXI1	5	36	41	1597.736
#451	NANOG	5	31	36	5423.719
#452	MSX1	5	30	35	451.826
#453	ZNF277	5	33	38	824.707
#454	RFXAP	5	28	33	651.376
#455	ARX	5	37	42	813.673
#456	RUNX1T1	5	34	39	903.161
#457	HOXA2	5	32	37	636.216
#458	ESR1	4	31	35	553.426
#459	ANKRD30A	4	28	32	322.977
#460	NR5A2	4	37	41	215.131
#461	PLSCR1	4	32	36	127.334
#462	ARNTL2	4	43	47	537.226
#463	HOXD11	4	28	32	242.105
#464	IKZF4	4	21	25	420.429
#465	STRN3	4	28	32	202.765
#466	ZNF167	4	30	34	309.346
#467	GATA3	4	28	32	268.695
#468	PTH	4	27	31	843.835
#469	FOXB1	4	29	33	746.059
#470	MYT1L	4	27	31	134.084
#471	ETV1	4	23	27	184.034
#472	PHOX2B	4	35	39	883.452
#473	HOPX	4	38	42	1637.806
#474	HIRA	3	23	26	166.989
#475	TBX20	3	40	43	403.313
#476	NRL	3	32	35	356.108
#477	LHX9	3	36	39	826.086
#478	HNRNPAB	3	34	37	1085.395
#479	EHF	3	33	36	359.319
#480	ALS2CR8	3	31	34	1416.962
#481	TADA3	3	31	34	152.915
#482	TEAD4	3	30	33	272.266
#483	LMX1A	3	25	28	1574.85
#484	SALL1	3	37	40	205.059
#485	TSHZ2	3	38	41	1387.368
#486	FLI1	3	35	38	496.198
#487	ZNF80	3	41	44	1105.427
#488	MYCN	3	32	35	1443.709
#489	FOXP3	3	33	36	338.582
#490	LZTS1	2	35	37	254.349
#491	CRX	2	29	31	379.871
#492	SIX3	2	41	43	432.193
#493	FOSL2	2	29	31	147.248
#494	RORB	2	32	34	517
#495	HMGA2	2	25	27	50.166
#496	HOXB9	1	34	35	55.033
#497	SCML1	1	36	37	187.947
#498	ETV7	1	31	32	68.385
#499	PRDM2	1	30	31	37.716
#500	ZNF154	1	27	28	29.221