Hub Rank	Node	Children	Parents	Degree	Betweenness
#1	RUNX2	59	4	63	344.756
#2	CREB3L1	56	6	62	921.463
#3	ZNF367	52	3	55	699.038
#4	PBX1	49	1	50	71.348
#5	ZNF397	47	6	53	644.047
#6	BTG2	44	10	54	2102.248
#7	TCF4	44	10	54	3074.158
#8	SRF	43	7	50	1129.18
#9	IRF8	42	1	43	37.038
#10	FOXN3	41	12	53	1511.308
#11	JUNB	40	3	43	434.477
#12	MAX	40	5	45	1683.877
#13	MAFB	40	7	47	3864.798
#14	SALL2	40	13	53	1542.409
#15	GABPB1	39	7	46	2212.473
#16	GTF2I	37	1	38	21.697
#17	CREB5	37	9	46	1107.048
#18	GLI3	37	15	52	2271.107
#19	ELK3	37	5	42	407.218
#20	TCEAL1	37	7	44	448.472
#21	TWIST1	36	6	42	446.611
#22	VAV1	36	4	40	152.018
#23	MEIS2	36	9	45	1806.614
#24	MBD1	35	0	35	0
#25	TBX1	35	11	46	7716.779
#26	FLI1	35	6	41	2952.216
#27	ZNF148	34	5	39	380.778
#28	KLF15	34	16	50	5124.91
#29	HCLS1	33	7	40	3644.209
#30	ETS1	33	12	45	1897.937
#31	TCF19	33	4	37	266.025
#32	CREB1	33	4	37	566.312
#33	NOLC1	33	5	38	1689.598
#34	JDP2	33	8	41	468.259
#35	FOSL1	33	7	40	703.764
#36	THRA	32	10	42	1866.788
#37	CEBPB	32	9	41	1267.681
#38	ELF4	32	11	43	2467.851
#39	HOXC4	32	7	39	2820.492
#40	MITF	32	16	48	7656.252
#41	ATF2	31	3	34	83.461
#42	ELF2	31	10	41	2010.641
#43	CREBL2	30	7	37	2985.312
#44	ATF1	30	3	33	196.806
#45	FOSL2	29	12	41	839.21
#46	KLF4	29	6	35	895.489
#47	ELF1	29	7	36	484.36
#48	TRERF1	29	10	39	1189.866
#49	ZNF24	29	3	32	108.902
#50	FOXF1	29	11	40	1088.702
#51	GAS7	28	18	46	3805.657
#52	NFIX	28	14	42	2035.491
#53	POU2F1	28	9	37	999.465
#54	VDR	28	4	32	1273.411
#55	GATAD2B	28	10	38	1100.637
#56	IRF1	28	7	35	480.572
#57	TCF12	27	11	38	2129.175
#58	PTTG1	27	3	30	1281.837
#59	MEIS1	27	7	34	178.929
#60	C5orf41	27	13	40	1507.59
#61	ETV5	26	14	40	1099.128
#62	RUNX1	26	12	38	872.914
#63	SPEN	26	5	31	300.5
#64	CNOT8	26	10	36	682.391
#65	TFEC	25	4	29	694.624
#66	HMGA1	25	8	33	1298.39
#67	LZTS1	25	7	32	1089.462
#68	EBF1	25	10	35	920.862
#69	HIC1	25	5	30	337.163
#70	HEY2	25	11	36	1442.795
#71	HMGB2	25	3	28	192.885
#72	RB1	25	5	30	472.216
#73	NFIA	25	10	35	2700.611
#74	ZFHX3	24	10	34	3125.914
#75	BCL6	24	15	39	1753.462
#76	HEY1	24	16	40	1821.892
#77	IKZF1	24	3	27	215.041
#78	TEAD4	24	14	38	1058.39
#79	STAT1	23	3	26	186.041
#80	KDM5B	23	16	39	5446.953
#81	BCL3	23	19	42	2900.283
#82	KLF2	23	14	37	947.714
#83	EPAS1	23	4	27	359.783
#84	HOXC13	23	14	37	1418.577
#85	FOXM1	22	6	28	1420.829
#86	CREBZF	22	5	27	673.673
#87	BACH2	22	9	31	827.082
#88	E2F1	22	4	26	589.407
#89	KLF3	22	10	32	596.473
#90	NR3C1	22	7	29	942.916
#91	GCFC1	22	6	28	509.393
#92	TCF7L2	22	13	35	2517.813
#93	LEF1	22	11	33	1432.639
#94	PRRX2	21	12	33	2288.995
#95	SATB1	21	13	34	1087.233
#96	ZNF41	21	7	28	273.353
#97	NFAT5	21	8	29	856.354
#98	MYOD1	21	6	27	827.425
#99	TRIM22	21	7	28	777.751
#100	FOXO6	21	12	33	2582.918
#101	C1orf85	21	13	34	2710.365
#102	NR2F2	21	17	38	1406.719
#103	SMAD3	21	14	35	1420.013
#104	MEF2C	21	22	43	3364.782
#105	RERE	21	10	31	1421.573
#106	SIN3A	20	13	33	2325.484
#107	UHRF1	20	7	27	928.165
#108	STAT3	20	6	26	404.318
#109	STAT6	20	13	33	695.572
#110	SMAD2	20	12	32	1421.312
#111	KLF6	19	9	28	1639.546
#112	ZNF281	19	18	37	1573.321
#113	STAT5B	19	14	33	2185.004
#114	TEAD3	19	12	31	815.472
#115	CSRNP1	19	3	22	538.669
#116	RELA	19	10	29	799.47
#117	PLSCR1	19	17	36	3730.508
#118	SIX1	19	10	29	816.81
#119	MSC	19	14	33	2244.208
#120	SOX8	19	14	33	1788.356
#121	HOXA10	19	10	29	649.74
#122	SMAD1	18	14	32	1052.12
#123	GABPA	18	8	26	388.571
#124	TEAD1	18	16	34	1930.745
#125	DLX6	18	16	34	2185.35
#126	HMGA2	18	11	29	1673.154
#127	TFE3	18	8	26	1215.917
#128	STRN3	18	8	26	1844.047
#129	MAF	18	14	32	1144.625
#130	MYC	18	13	31	1413.29
#131	IRF6	18	17	35	1946.551
#132	JUND	18	14	32	1486.675
#133	TAF5	18	11	29	1311.203
#134	BHLHE40	17	16	33	1050.577
#135	GLIS3	17	17	34	2734.352
#136	SIX5	17	13	30	959.814
#137	SNAPC5	17	22	39	3489.379
#138	SNAPC4	17	13	30	657.293
#139	HOPX	17	14	31	2063
#140	SIX2	17	15	32	481.542
#141	SP1	17	7	24	373.528
#142	PRRX1	17	12	29	785.238
#143	IRF7	17	8	25	426.301
#144	HMG20B	17	14	31	1863.142
#145	ATF3	17	14	31	1416.838
#146	HHEX	17	14	31	1330.819
#147	SOX15	16	12	28	2568.668
#148	SNAI2	16	11	27	459.997
#149	PCGF2	16	12	28	691.488
#150	MAFF	16	15	31	1110.084
#151	EGR2	16	18	34	1840.527
#152	HOXA9	16	7	23	979.071
#153	PRDM2	16	16	32	1202.205
#154	RUNX1T1	16	17	33	1363.076
#155	TFCP2	16	4	20	41.509
#156	PEG3	16	16	32	2141.992
#157	MLLT10	16	11	27	1207.144
#158	PGR	15	23	38	1790.118
#159	RFX5	15	16	31	1409.361
#160	IRF9	15	6	21	878.967
#161	NFKB2	15	9	24	984.351
#162	PKNOX2	15	11	26	2262.386
#163	NFX1	15	8	23	456.435
#164	NKX2-5	15	12	27	1461.804
#165	ZSCAN2	15	12	27	887.983
#166	SOX4	15	20	35	1209.71
#167	ZFHX4	15	20	35	1574.006
#168	MYCN	15	10	25	705.318
#169	SOX12	15	13	28	1402.183
#170	TSHZ2	15	14	29	715.854
#171	SIX4	15	15	30	1254.238
#172	HOXA3	15	10	25	1712.539
#173	TARDBP	15	12	27	1104.947
#174	ZBTB38	15	11	26	665.973
#175	SOLH	15	14	29	2348.401
#176	HOXC11	15	11	26	1447.768
#177	ZSCAN18	15	17	32	2786.099
#178	HDAC1	15	15	30	1421.725
#179	MEF2A	15	13	28	833.007
#180	PAX7	14	5	19	203.696
#181	CTNNB1	14	6	20	682.478
#182	MYBL2	14	8	22	1779.731
#183	ETV6	14	15	29	1123.609
#184	HLF	14	17	31	1332.397
#185	ZIC2	14	9	23	967.384
#186	TGIF2	14	19	33	1821.101
#187	ELK1	14	13	27	3112.075
#188	TSHZ1	14	12	26	621.321
#189	HOXA5	14	11	25	2026.883
#190	E2F3	14	10	24	918.527
#191	TULP4	14	9	23	292.38
#192	ZKSCAN1	14	8	22	743.923
#193	NANOG	14	15	29	2965.324
#194	GATA3	14	13	27	806.93
#195	HOXC9	13	16	29	1248.038
#196	NR1H3	13	15	28	2037.707
#197	ADNP2	13	9	22	401.174
#198	AHCTF1	13	16	29	992.459
#199	E2F7	13	9	22	251.434
#200	GTF2H4	13	13	26	341.495
#201	ETS2	13	19	32	855.158
#202	EN1	13	17	30	869.057
#203	FOXP4	13	17	30	1222.545
#204	ZFP36L2	13	19	32	1309.157
#205	CBFB	13	20	33	1788.571
#206	NOTCH1	13	17	30	2119.885
#207	MYF5	13	7	20	907.728
#208	ZNF238	13	17	30	1503.498
#209	CREM	13	18	31	932.563
#210	PRDM1	13	10	23	3744.613
#211	EGR3	13	10	23	1931.541
#212	TFAM	13	24	37	4271.544
#213	CDKN2A	13	18	31	1046.26
#214	NFIB	13	20	33	3718.973
#215	FOXK2	12	11	23	1246.753
#216	FOXL2	12	16	28	1462.317
#217	SOX2	12	12	24	1339.12
#218	CSDA	12	20	32	2904.038
#219	NKX3-1	12	15	27	2943.621
#220	MEIS3P1	12	13	25	1254.84
#221	MGA	12	7	19	426.382
#222	SCMH1	12	15	27	500.883
#223	XBP1	12	9	21	293.16
#224	MYNN	12	16	28	1456.63
#225	FOS	12	3	15	730.615
#226	PBX2	12	14	26	1127.464
#227	FOXC2	12	15	27	2960.215
#228	ZGPAT	12	21	33	811.423
#229	KLF12	12	16	28	2075.271
#230	TSHZ3	12	17	29	1752.602
#231	NR3C2	12	16	28	2618.811
#232	RXRB	12	12	24	557.691
#233	ZNF75D	12	13	25	400.177
#234	NFIL3	12	13	25	1174.181
#235	ZEB1	11	9	20	501.38
#236	ZBTB25	11	14	25	656.133
#237	JUN	11	10	21	876.472
#238	NFYB	11	16	27	1069.243
#239	NCOR1	11	10	21	538.037
#240	ETV4	11	15	26	1165.948
#241	MEOX2	11	20	31	512.928
#242	KLF9	11	15	26	649.378
#243	SIM2	11	15	26	2823.906
#244	SMAD9	11	20	31	1291.608
#245	NFATC3	11	16	27	3128.762
#246	IRX3	11	14	25	2752.66
#247	SP4	11	17	28	1202.487
#248	FOXL1	11	15	26	985.101
#249	KLF7	11	15	26	767.729
#250	GLI2	11	12	23	394.306
#251	ZEB2	11	16	27	755.323
#252	REL	11	11	22	603.072
#253	CBFA2T3	11	6	17	920.562
#254	HIF3A	11	20	31	3084.671
#255	GATA2	11	21	32	1929.449
#256	ZNF167	10	19	29	1118.929
#257	EGR1	10	6	16	352.167
#258	IRX2	10	16	26	1853.412
#259	ETV1	10	11	21	591.205
#260	LHX2	10	21	31	1543.563
#261	TCF7L1	10	17	27	2664.282
#262	CITED2	10	15	25	964.561
#263	TFDP1	10	15	25	1014.616
#264	TRPS1	10	18	28	1251.06
#265	NR4A3	10	12	22	443.812
#266	CEBPA	10	12	22	1018.502
#267	ISL1	10	18	28	1020.428
#268	BATF2	10	11	21	492.486
#269	ZNF93	10	18	28	1344.853
#270	EGR4	10	4	14	266.329
#271	TBX15	10	12	22	730.83
#272	SMAD4	10	13	23	1248.326
#273	CBL	10	7	17	992.654
#274	RORB	10	17	27	3620.278
#275	BATF3	10	17	27	1564.464
#276	E2F6	10	15	25	881.124
#277	ZFP37	10	15	25	1117.284
#278	PHF5A	10	12	22	322.603
#279	NFYC	10	15	25	537.675
#280	ZNF131	10	15	25	460.232
#281	HSF2	10	13	23	1501.648
#282	NANOGNB	10	13	23	1906.16
#283	FUBP1	10	18	28	1167.75
#284	ZNF217	10	16	26	794.919
#285	ZNF35	10	9	19	1261.221
#286	MAFK	9	18	27	1618.191
#287	HOXA13	9	6	15	225.037
#288	ZNF70	9	17	26	1097.141
#289	ZNF133	9	16	25	1230.495
#290	NR4A2	9	5	14	56.957
#291	MMP14	9	13	22	332.246
#292	TFAP2C	9	14	23	932.118
#293	ARNT2	9	14	23	757.867
#294	E2F8	9	8	17	497.26
#295	PHTF1	9	18	27	861.213
#296	MSX1	9	18	27	2852.854
#297	SCML1	9	22	31	737.509
#298	PLAG1	9	16	25	2242.862
#299	TBX2	9	21	30	2614.591
#300	HOXB3	9	13	22	1660.25
#301	ZNF277	9	12	21	1757.279
#302	TEAD2	9	20	29	1366.284
#303	FOXD1	9	18	27	1752.671
#304	SMAD5	9	9	18	421.765
#305	NR4A1	9	9	18	1606.367
#306	CSRNP2	9	17	26	956.686
#307	ALX1	9	14	23	1178.028
#308	ZHX1	9	16	25	2408.221
#309	RARB	8	21	29	1515.562
#310	HOXB5	8	11	19	686.521
#311	MLL	8	16	24	390.118
#312	RELB	8	9	17	250.33
#313	EOMES	8	6	14	275.22
#314	NFE2L3	8	13	21	434.521
#315	CNOT7	8	17	25	1333.748
#316	NFYA	8	22	30	1559.531
#317	TCF3	8	23	31	1288.651
#318	ZNF500	8	22	30	1711.442
#319	HOXD1	8	15	23	1406.441
#320	WNT5A	8	17	25	1193.114
#321	NR1D2	8	16	24	1042.289
#322	FOXO1	8	21	29	1193.249
#323	FOSB	8	3	11	112.283
#324	ZNF18	8	11	19	429.431
#325	AEBP1	8	19	27	369.058
#326	ZXDC	8	10	18	792.46
#327	HOXB6	8	12	20	839.082
#328	FOXP1	8	16	24	1077.674
#329	MSRB2	8	18	26	790.359
#330	ESR1	8	16	24	1587.675
#331	RUNX3	8	23	31	1056.039
#332	HOXB2	8	13	21	1430.035
#333	TWIST2	8	13	21	554.46
#334	HOXA11	8	13	21	1294.086
#335	DMRT2	8	17	25	1175.43
#336	HES1	8	20	28	1270.856
#337	CREB3	8	16	24	357.337
#338	ZNF639	8	12	20	657.517
#339	ERG	8	14	22	1305.841
#340	C11orf9	8	15	23	524.853
#341	ARNTL2	8	17	25	1681.787
#342	STAT2	7	14	21	530.264
#343	ZNF117	7	17	24	960.9
#344	CEBPD	7	17	24	564.129
#345	RBCK1	7	19	26	928.983
#346	SP140	7	7	14	49.717
#347	ARNT	7	15	22	252.455
#348	ZNF83	7	19	26	605.419
#349	HOXB9	7	13	20	1032.53
#350	HOXA1	7	13	20	988.288
#351	BCL11B	7	19	26	1467.752
#352	PAX8	7	15	22	443.583
#353	IRX1	7	15	22	671.936
#354	ZNF287	7	12	19	605.325
#355	HOXD13	7	16	23	991.1
#356	HOXB7	7	11	18	1017.534
#357	ATF5	7	19	26	767.388
#358	CSRNP3	7	14	21	649.346
#359	ZNF91	7	19	26	847.918
#360	ZNF207	7	15	22	877.762
#361	HOXD4	7	15	22	530.583
#362	DBP	7	20	27	689.048
#363	MYF6	7	11	18	1043.472
#364	DLX1	7	16	23	2372.992
#365	AFF4	7	14	21	287.112
#366	HOXA7	7	9	16	304.77
#367	TP63	7	18	25	1297.375
#368	GLIS2	7	21	28	764.823
#369	PGBD1	6	17	23	1685.277
#370	MEIS3	6	16	22	951.642
#371	VTN	6	13	19	540.854
#372	DLX4	6	13	19	766.251
#373	AHR	6	12	18	253.202
#374	CREB3L2	6	19	25	1166.162
#375	PBX3	6	19	25	872.139
#376	ESRRG	6	13	19	616.92
#377	ARNTL	6	19	25	627.213
#378	MYPOP	6	13	19	1071.07
#379	SALL1	6	22	28	655.9
#380	ZNF496	6	20	26	979.03
#381	FOXG1	6	16	22	1038.249
#382	TBX5	6	17	23	819.763
#383	NFXL1	6	16	22	1646.772
#384	SLC30A9	6	15	21	427.024
#385	ZNF232	6	21	27	3428.9
#386	TSC22D3	6	15	21	606.171
#387	HOXD3	6	15	21	590.609
#388	FOXF2	6	18	24	1496.132
#389	NFATC4	6	15	21	1900.313
#390	ZFP90	6	19	25	897.264
#391	PROX1	6	14	20	303.309
#392	MKX	6	20	26	1177.453
#393	L3MBTL4	6	18	24	1060.281
#394	SOX11	6	23	29	819.328
#395	HMBOX1	6	17	23	664.307
#396	TFDP2	6	16	22	1101.003
#397	ZNF45	6	10	16	558.636
#398	GATA6	5	17	22	196.942
#399	LHX6	5	15	20	1118.225
#400	STAT4	5	10	15	286.451
#401	MSX2	5	19	24	2394.597
#402	NFIC	5	15	20	547.291
#403	LHX8	5	19	24	1117.008
#404	LHX9	5	19	24	1443.204
#405	NFATC1	5	22	27	1044.07
#406	SIM1	5	10	15	1051.348
#407	PITX2	5	23	28	1140.738
#408	SLC2A4RG	5	13	18	275.426
#409	PPARG	5	20	25	983.216
#410	ZXDA	5	22	27	594.022
#411	NR2F1	5	28	33	1141.601
#412	IRX5	5	17	22	740.63
#413	WT1	5	14	19	346.746
#414	MEOX1	5	15	20	402.813
#415	SATB2	5	23	28	4011.025
#416	CREB3L4	5	12	17	357.725
#417	KLF11	5	22	27	680.416
#418	ZNF274	5	20	25	685.162
#419	TRIM25	5	14	19	441.725
#420	PCGF6	5	10	15	261.561
#421	PURB	5	14	19	580.813
#422	HEYL	5	12	17	238.122
#423	KDM5A	5	13	18	274.089
#424	ZFPM2	5	24	29	431.155
#425	SCAND1	5	15	20	616.632
#426	TSC22D1	5	20	25	578.35
#427	IRF4	5	16	21	783.335
#428	HES6	5	16	21	478.856
#429	AR	4	15	19	167.07
#430	POU6F1	4	20	24	598.041
#431	FOXC1	4	24	28	277.075
#432	HOXC10	4	8	12	174.759
#433	KLF5	4	20	24	567.676
#434	BNC1	4	17	21	1186.087
#435	MXD1	4	16	20	513.249
#436	UBN1	4	12	16	203.339
#437	TAF4B	4	21	25	613.238
#438	HOXA2	4	11	15	872.873
#439	MECOM	4	21	25	1147.928
#440	HOXD8	4	16	20	720.42
#441	ZNF140	4	15	19	705.273
#442	SMAD6	4	19	23	334.32
#443	LASS6	4	20	24	1053.301
#444	ETV3	4	7	11	50.348
#445	TFEB	4	19	23	1793.887
#446	TRIM29	4	13	17	649.33
#447	PPARA	4	17	21	1018.775
#448	HOXD11	4	8	12	1077.839
#449	TEF	4	14	18	830.024
#450	NFATC2	4	10	14	897.575
#451	ZHX2	4	21	25	389.204
#452	ZNF438	4	24	28	477.411
#453	ZNF498	4	20	24	392.301
#454	BHLHE41	4	20	24	372.273
#455	TFAP2A	4	18	22	652.357
#456	TCFL5	4	20	24	772.572
#457	ZHX3	4	14	18	395.146
#458	SOX13	3	17	20	601.293
#459	RCAN1	3	15	18	193.452
#460	NKX3-2	3	19	22	653.052
#461	ATF6	3	15	18	348.051
#462	ZNF85	3	15	18	477.528
#463	IRF5	3	5	8	666.316
#464	TCF21	3	24	27	808.456
#465	CBFA2T2	3	19	22	219.039
#466	ATF7	3	12	15	488.838
#467	ERF	3	12	15	226.176
#468	SIX3	3	15	18	997.347
#469	LMO4	3	14	17	392.363
#470	ZNF268	3	16	19	472.488
#471	SOX6	3	22	25	361.18
#472	ZNF323	3	18	21	451.124
#473	PAX3	3	17	20	332.536
#474	FOXQ1	3	20	23	588.453
#475	ZC3H8	3	21	24	547.475
#476	GTF2IRD1	3	14	17	298.107
#477	ZNF202	3	24	27	333.267
#478	SOX9	2	26	28	938.876
#479	TAF1B	2	15	17	186.831
#480	RARA	2	19	21	385.472
#481	TCF7	2	15	17	77.619
#482	SOX7	2	16	18	286.827
#483	ENO1	2	20	22	134.541
#484	SREBF1	2	15	17	149.044
#485	NFE2L2	2	13	15	400.912
#486	MZF1	2	21	23	819.332
#487	HOXD10	2	18	20	834.526
#488	PAX6	2	20	22	494.099
#489	RORA	2	20	22	332.95
#490	TGIF1	2	18	20	434.636
#491	TP53	1	22	23	137.777
#492	NPAS2	1	18	19	118.126
#493	FOXP2	1	18	19	137.604
#494	FOXS1	1	16	17	180.876
#495	ZFP36L1	1	16	17	96.752
#496	DDIT3	1	21	22	120.784
#497	TBX3	1	25	26	227.013
#498	ZIC1	1	22	23	138.352
#499	THRB	1	21	22	95.658
#500	CTBP1	0	17	17	0