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Hub Rank	Node	Children	Parents	Degree	Betweenness
#1	TRPS1	48	1	49	67.176
#2	NFYB	46	3	49	436.002
#3	FOXN3	45	6	51	4315.873
#4	E2F1	41	7	48	813.429
#5	FOXO3	41	11	52	607.446
#6	SP1	41	5	46	530.259
#7	MEF2C	41	4	45	175.907
#8	ZNF277	40	2	42	175.97
#9	NR3C2	40	4	44	6944.567
#10	GATAD2A	40	9	49	620.606
#11	PEG3	38	4	42	437.643
#12	FOXQ1	38	7	45	571.296
#13	MEIS1	37	4	41	1925.372
#14	ZFP90	37	6	43	595.259
#15	KLF9	36	10	46	4556.639
#16	TSHZ1	36	16	52	9655.042
#17	YBX1	35	8	43	719.306
#18	ETV4	35	6	41	622.764
#19	FOXF2	35	7	42	1206.747
#20	ZEB2	35	4	39	146.137
#21	PBX1	35	6	41	5376.204
#22	YY1	34	5	39	609.038
#23	GTF2IRD1	34	5	39	1657.189
#24	NFIA	34	12	46	5638.9
#25	TSHZ3	34	4	38	130.99
#26	TCF25	34	3	37	1552.311
#27	KLF4	34	9	43	1574.244
#28	ESR1	33	9	42	2148.266
#29	ZEB1	33	6	39	1135.021
#30	NR3C1	33	10	43	619.174
#31	ENO1	33	7	40	448.962
#32	TFDP1	32	3	35	291.98
#33	FOXF1	32	10	42	449.212
#34	CREB1	32	2	34	108.421
#35	KLF6	32	9	41	980.215
#36	TULP4	30	10	40	1877.377
#37	PPARA	30	7	37	537.129
#38	NR5A2	30	8	38	402.935
#39	CIR1	30	7	37	357.114
#40	ETV5	30	12	42	2677.753
#41	NKX2-3	29	7	36	648.212
#42	EPAS1	29	12	41	1438.12
#43	ZNF219	29	6	35	3293.196
#44	C12orf28	29	16	45	4977.324
#45	FOXM1	28	7	35	306.615
#46	FLI1	28	6	34	1164.027
#47	ZNF281	28	9	37	618.355
#48	RXRB	28	9	37	1138.111
#49	CSDA	28	14	42	1625.809
#50	TFAM	27	11	38	3807.348
#51	HCLS1	27	5	32	329.4
#52	MAX	27	7	34	3590.697
#53	HMGB1	27	10	37	798.613
#54	PBX3	27	5	32	822.921
#55	MGA	27	14	41	2398.926
#56	FOXD4	27	7	34	1487.196
#57	ZBTB38	27	3	30	54.099
#58	KLF5	26	13	39	1089.998
#59	ZFPM2	25	10	35	382.967
#60	BHLHE41	25	13	38	1023.505
#61	FOXP2	25	14	39	2461.988
#62	RORA	25	6	31	520.452
#63	NFX1	25	6	31	235.443
#64	CNOT8	24	7	31	464.896
#65	MITF	24	7	31	568.445
#66	ZNF24	24	10	34	2789.362
#67	ELF1	24	7	31	713.721
#68	NFE2L3	24	12	36	537.699
#69	SOX9	24	16	40	1633.339
#70	CDX2	24	15	39	4051.464
#71	FOXO1	24	11	35	1865.739
#72	ISX	23	12	35	1191.576
#73	TSC22D2	23	14	37	890.595
#74	NOLC1	23	9	32	360.941
#75	TEAD4	23	7	30	1800.179
#76	ARNT2	23	15	38	4198.597
#77	REL	23	12	35	891.753
#78	EBF1	23	10	33	305.139
#79	E2F2	23	7	30	636.475
#80	CUX2	23	6	29	1753.321
#81	SOX4	22	15	37	2257.704
#82	FOXP4	22	11	33	1462.972
#83	ATF1	22	6	28	1034.004
#84	SLC26A3	22	15	37	11502.9
#85	ASCL2	22	14	36	3511.019
#86	ZNF37A	22	13	35	1055.984
#87	TGIF2LY	21	6	27	519.394
#88	RUNX1	21	1	22	354.793
#89	RCAN1	21	11	32	1490.303
#90	CITED2	21	8	29	2004.358
#91	MSX1	21	17	38	5497.863
#92	NKX3-1	21	11	32	1319.033
#93	DLX2	21	7	28	459.417
#94	ARNTL	21	10	31	406.726
#95	ZNF45	21	9	30	546.934
#96	TCF7L1	21	10	31	529.241
#97	HES6	21	15	36	2186.589
#98	ZNF238	20	8	28	170.919
#99	SPIB	20	13	33	999.961
#100	HOXB5	20	6	26	1011.556
#101	SALL2	20	14	34	1100.8
#102	ISL2	20	7	27	1079.34
#103	MMP14	20	13	33	1837.535
#104	HOXA9	20	11	31	1956.792
#105	STAT3	20	13	33	370.328
#106	ATF6	20	9	29	201.634
#107	E2F5	20	14	34	1055.563
#108	ETV1	20	11	31	612.209
#109	ZNF148	20	4	24	79.379
#110	HHEX	19	18	37	3856.049
#111	SOX12	19	14	33	1315.229
#112	IRF6	19	10	29	1252.432
#113	RB1	19	12	31	856.589
#114	SMAD9	19	10	29	982.688
#115	MSX2	19	18	37	1266.296
#116	KLF16	19	14	33	1545.596
#117	HNF1B	19	15	34	1301.427
#118	PPARG	19	14	33	2635.698
#119	FOSL2	19	10	29	837.06
#120	SP4	19	13	32	416.925
#121	CBFB	19	7	26	207.909
#122	HOXB2	19	19	38	5884.092
#123	HEY2	19	14	33	869.723
#124	MEIS2	19	14	33	983.832
#125	ZNF41	18	15	33	771.483
#126	GAS7	18	12	30	648.211
#127	ZNF397	18	8	26	415.698
#128	KLF3	18	15	33	1293.916
#129	E2F7	18	8	26	220.524
#130	NR1I2	18	15	33	799.051
#131	ZNF75D	18	13	31	846.737
#132	ZNF19	18	12	30	2160.356
#133	FOXA3	18	8	26	544.518
#134	ZNF207	18	10	28	579.512
#135	TEAD1	18	13	31	3577.898
#136	STAT6	18	8	26	198.507
#137	NFIX	17	17	34	2453.458
#138	EGR2	17	9	26	536.156
#139	TSC22D3	17	9	26	953.801
#140	HOXA7	17	8	25	1707.479
#141	ARX	17	14	31	2720.257
#142	C11orf9	17	16	33	3127.603
#143	HSF1	17	11	28	1822.244
#144	RCOR1	17	10	27	2182.95
#145	TAF1B	17	12	29	2377.859
#146	SALL1	17	11	28	1079.638
#147	SIM2	17	14	31	708.745
#148	NR4A3	17	4	21	212.262
#149	MYBL2	17	6	23	106.391
#150	NFKB2	16	13	29	1200.013
#151	GATA6	16	13	29	2697.531
#152	SOX6	16	16	32	1284.748
#153	CBFA2T2	16	13	29	1534.573
#154	IKZF1	16	17	33	5187.4
#155	ZKSCAN1	16	18	34	1900.422
#156	ZSCAN2	16	12	28	1527.846
#157	MEOX2	16	16	32	706.084
#158	GABPA	16	10	26	550.959
#159	STAT1	16	12	28	939.99
#160	HLF	16	11	27	395.277
#161	ZFHX3	16	16	32	1296.718
#162	BATF2	16	14	30	1614.483
#163	ZNF117	16	10	26	1392.799
#164	ZNF83	16	15	31	1798.414
#165	KLF2	16	13	29	1358.96
#166	TBX10	16	18	34	1554.69
#167	RAX	16	9	25	1000.635
#168	AHCTF1	16	14	30	552.734
#169	RELA	16	16	32	1716.266
#170	HOXA13	16	14	30	2666.985
#171	SOX17	16	17	33	3840.093
#172	ONECUT2	15	25	40	2192.117
#173	NR1D2	15	12	27	1139.362
#174	TGIF2	15	10	25	233.592
#175	TFAP2A	15	9	24	1109.718
#176	NFAT5	15	11	26	486.747
#177	BCL3	15	9	24	512.444
#178	TADA2A	15	14	29	610.28
#179	MYF5	15	9	24	591.68
#180	NFE2L2	15	20	35	1294.968
#181	NFIB	15	19	34	790.999
#182	CEBPD	15	21	36	1682.243
#183	SOX7	15	14	29	1088.917
#184	NR1H4	15	14	29	772.185
#185	TBX3	15	16	31	2566.239
#186	RARB	15	9	24	732.639
#187	TFEC	14	12	26	2118.439
#188	GTF2H2	14	10	24	293.54
#189	SIX4	14	26	40	3594.278
#190	CSRNP1	14	8	22	599.323
#191	GATAD2B	14	18	32	1094.414
#192	SCML1	14	15	29	8388.969
#193	PTTG1	14	8	22	234.579
#194	ZFP36L2	14	12	26	578.428
#195	IRF4	14	6	20	703.321
#196	MTA1	14	11	25	1373.783
#197	SMAD2	14	12	26	2863.223
#198	HR	14	16	30	2453.017
#199	C5orf41	14	9	23	460.104
#200	NR2F6	14	15	29	404.833
#201	TFDP2	14	19	33	4741.729
#202	MEOX1	14	18	32	1506.714
#203	SIM1	14	11	25	2053.854
#204	EHF	14	11	25	242.054
#205	MESP1	14	15	29	1453.603
#206	LASS6	14	13	27	229.184
#207	ATOH1	14	17	31	1289.507
#208	ANKRD30A	14	12	26	1674.397
#209	SP140	13	15	28	1472.41
#210	NEUROD1	13	16	29	294.407
#211	ZFP36L1	13	14	27	2083.508
#212	SATB2	13	23	36	1406.069
#213	MAF	13	15	28	641.764
#214	ETV6	13	12	25	676.319
#215	FOXE1	13	13	26	8299.228
#216	FOXA2	13	21	34	2141.082
#217	HOXA10	13	13	26	2082.744
#218	ZFP42	13	17	30	1787.288
#219	TCFL5	13	13	26	1244.578
#220	MNX1	13	15	28	2042.486
#221	SOX21	13	9	22	536.919
#222	KLF7	13	10	23	172.982
#223	LHX8	13	10	23	1625.244
#224	RXRG	13	11	24	1570.665
#225	MAFB	13	11	24	1638.888
#226	ZRANB2	13	13	26	1350.629
#227	AEBP1	12	9	21	478.425
#228	JUNB	12	8	20	1837.188
#229	TCF21	12	16	28	292.463
#230	WNT5A	12	20	32	1634.954
#231	ETS1	12	14	26	738.215
#232	SPDEF	12	10	22	880.463
#233	FOXC1	12	22	34	1339.567
#234	CNOT7	12	15	27	3026.492
#235	MXD1	12	12	24	828.137
#236	TRIM29	12	19	31	1260.75
#237	HOXA3	12	13	25	1445.338
#238	TCF7L2	12	14	26	467.8
#239	MBD1	12	12	24	1217.244
#240	MYNN	12	12	24	727.823
#241	CEBPA	12	13	25	709.338
#242	PRRX1	12	11	23	931.523
#243	TFAP2B	12	18	30	1421.117
#244	AFF4	12	12	24	321.963
#245	ZFHX4	12	13	25	3742.091
#246	JUND	12	13	25	813.091
#247	ZNF367	12	14	26	689.497
#248	HOPX	12	10	22	256.875
#249	UHRF1	12	9	21	160.217
#250	SOX10	12	15	27	502.491
#251	FOSB	12	14	26	482.38
#252	NR4A2	11	7	18	373.245
#253	TRIM22	11	16	27	708.79
#254	TGIF1	11	14	25	1003.579
#255	HOXB9	11	15	26	875.279
#256	ERG	11	11	22	895.971
#257	SOX2	11	22	33	2873.012
#258	ZSCAN4	11	17	28	463.239
#259	TAF10	11	14	25	1112.834
#260	SPEN	11	12	23	606.836
#261	CITED1	11	13	24	984.727
#262	HOXA11	11	13	24	2108.36
#263	PITX1	11	18	29	2967.588
#264	HOXA5	11	9	20	1082.818
#265	WT1	11	14	25	536.123
#266	MEIS3P1	11	15	26	1402.666
#267	EVX1	11	15	26	1957.428
#268	TCF12	11	15	26	1415.398
#269	TWIST1	10	17	27	1290.068
#270	BTG2	10	18	28	864.325
#271	TP53	10	19	29	4193.424
#272	PLAGL2	10	15	25	1836.844
#273	CREM	10	10	20	1111.873
#274	CREB5	10	12	22	2876.625
#275	SCAND3	10	16	26	4567.406
#276	KCNH8	10	13	23	1096.708
#277	ZXDC	10	17	27	1784.097
#278	GLIS3	10	18	28	1127.321
#279	HOXD12	10	12	22	1068.812
#280	RFXAP	10	15	25	462.751
#281	TP73	10	15	25	1484.917
#282	LHX9	10	17	27	2719.06
#283	VSX1	10	14	24	989.24
#284	DMRT2	10	16	26	870.488
#285	ESRRG	10	9	19	624.045
#286	MYCN	10	11	21	364.28
#287	NR4A1	10	8	18	344.276
#288	GTF2H3	10	8	18	176.131
#289	HNF4A	10	15	25	555.691
#290	ZNF91	9	13	22	282.524
#291	PPARD	9	15	24	510.702
#292	ZNF93	9	16	25	1535.281
#293	ETV7	9	15	24	629.104
#294	PA2G4	9	14	23	167.649
#295	MEF2A	9	17	26	1162.864
#296	SP3	9	16	25	403.331
#297	KDM5B	9	18	27	1081.868
#298	ZSCAN18	9	17	26	971.307
#299	LEF1	9	16	25	921.04
#300	BCL11B	9	19	28	773.11
#301	IRX3	9	17	26	941.692
#302	ZNF71	9	13	22	577.805
#303	TAL1	9	18	27	829.977
#304	ZIC1	9	16	25	2580.519
#305	ZNF131	9	13	22	3377.255
#306	GATA4	9	17	26	1733.922
#307	GATAD1	9	13	22	410.025
#308	RUNX3	9	17	26	2400.408
#309	HOXB3	9	19	28	1814.925
#310	VENTX	9	14	23	575.296
#311	ZNF154	9	18	27	1371.286
#312	RBPJL	9	13	22	2428.291
#313	LASS5	9	16	25	2398.663
#314	FOXR1	9	16	25	2292.11
#315	TCF3	9	16	25	831.415
#316	SIX1	9	15	24	1017.644
#317	ATF3	9	15	24	428.279
#318	LMO4	9	14	23	1301.228
#319	FOXP1	9	14	23	681.579
#320	HSF2	9	14	23	678.508
#321	HNF4G	9	21	30	727.16
#322	MECOM	9	16	25	450.32
#323	HOXD3	9	15	24	935.449
#324	LHX5	9	22	31	1379.001
#325	CSRNP3	9	16	25	449.695
#326	PAX3	9	19	28	1036.524
#327	VDR	9	14	23	515.256
#328	MYC	9	19	28	916.067
#329	PAX6	9	15	24	801.109
#330	ETV3	8	18	26	493.549
#331	NKX3-2	8	11	19	162.691
#332	GCFC1	8	17	25	4842.88
#333	FOXA1	8	18	26	5035.726
#334	BHLHE40	8	17	25	286.138
#335	ZNF92	8	18	26	406.634
#336	FOXG1	8	17	25	3708.762
#337	BACH2	8	17	25	387.181
#338	HCFC1	8	19	27	1152.929
#339	CTBP1	8	17	25	2285.618
#340	FOS	8	12	20	680.428
#341	ETS2	8	19	27	307.948
#342	JUN	8	20	28	8553.885
#343	EGR1	8	8	16	165.179
#344	SOX11	8	22	30	2220.722
#345	MLXIPL	8	16	24	704.57
#346	SIX5	8	18	26	751.205
#347	HOXD13	8	15	23	1108.897
#348	HOXB8	8	13	21	816.897
#349	NPAS2	8	18	26	1025.767
#350	PLSCR1	7	16	23	536.825
#351	PRDM1	7	19	26	401.599
#352	TBX5	7	15	22	1068.846
#353	TFAP2C	7	19	26	1411.429
#354	IRX5	7	13	20	898.227
#355	FOXE3	7	17	24	1162.122
#356	TFCP2L1	7	20	27	901.936
#357	ATF5	7	16	23	1071.657
#358	CREB3L1	7	15	22	652.967
#359	SOLH	7	17	24	437.046
#360	HOXB6	7	13	20	349.068
#361	PLAG1	7	17	24	799.353
#362	BCL6	7	17	24	709.978
#363	HAND1	7	10	17	93.346
#364	MAFF	7	13	20	1009.492
#365	RERE	7	17	24	3354.425
#366	EGR3	7	15	22	336.586
#367	NR2F2	7	18	25	625.82
#368	FOXD1	7	15	22	657.673
#369	EMX1	7	16	23	979.009
#370	SOX30	7	17	24	2693.347
#371	ISL1	7	14	21	467.648
#372	FOXC2	7	12	19	1511.765
#373	HMBOX1	7	16	23	1150.646
#374	ZNF192	7	16	23	290.506
#375	FOXJ1	7	16	23	332.729
#376	SOX8	7	16	23	1021.072
#377	POU2F2	7	22	29	1610.746
#378	HMGB2	7	19	26	907.522
#379	BATF	7	15	22	1001.544
#380	THRB	7	23	30	200.129
#381	ALX1	7	20	27	1463.191
#382	FOXK1	7	16	23	1054.987
#383	ARID3A	7	14	21	440.342
#384	ZNF165	7	18	25	771.552
#385	PAX8	7	15	22	911.643
#386	SATB1	6	16	22	1084.51
#387	ASCL1	6	12	18	879.695
#388	MYOG	6	21	27	1631.853
#389	MLLT10	6	19	25	2190.565
#390	STRN3	6	12	18	1056.467
#391	GRHL3	6	16	22	596.05
#392	TBX22	6	15	21	1278.258
#393	TAF13	6	13	19	566.819
#394	MKX	6	22	28	669.371
#395	HIF3A	6	22	28	2867.327
#396	HOXC13	6	18	24	876.621
#397	SPI1	6	15	21	1296.527
#398	HOXD4	6	17	23	1260.446
#399	NR2E1	6	17	23	2143.724
#400	RUNX2	6	17	23	4778.113
#401	CREBZF	6	13	19	824.643
#402	BACH1	6	15	21	312.518
#403	DLX6	6	22	28	1786.124
#404	NR1I3	6	15	21	1406.13
#405	TEAD2	6	21	27	1289.598
#406	SIX6	6	14	20	824.086
#407	ZNF396	5	22	27	345.583
#408	HOXB13	5	25	30	1184.553
#409	SOX5	5	13	18	1071.672
#410	ZSCAN23	5	21	26	564.07
#411	TSHZ2	5	19	24	535.978
#412	HMGA2	5	15	20	666.651
#413	PPBPL2	5	12	17	1337.044
#414	SOX1	5	20	25	392.466
#415	POU3F1	5	18	23	762.541
#416	ZNF80	5	18	23	1904.355
#417	LZTS1	5	17	22	637.948
#418	ELK1	5	18	23	558.282
#419	HOXC9	5	16	21	615.808
#420	MYT1L	5	15	20	307.498
#421	ZNF81	5	18	23	1253.696
#422	HOXA1	5	15	20	264.155
#423	RFX3	5	18	23	1115.51
#424	GATA5	5	15	20	845.812
#425	SNAI2	5	17	22	195.033
#426	PRDM2	5	17	22	3293.541
#427	PROX1	5	15	20	907.452
#428	BLZF1	5	12	17	484.441
#429	TCF15	5	19	24	1384.583
#430	HMGA1	5	12	17	135.691
#431	HESX1	5	15	20	350.567
#432	GATA3	5	15	20	1048.829
#433	L3MBTL4	5	15	20	3753.217
#434	ZNF643	5	15	20	654.018
#435	ZIC2	5	17	22	901.507
#436	ZNF132	5	11	16	400.377
#437	HOXD1	5	16	21	328.338
#438	TP63	5	14	19	3247.596
#439	POU2F1	4	16	20	308.827
#440	MLL	4	16	20	1266.336
#441	LHX2	4	12	16	565.623
#442	ARNT	4	17	21	1374.668
#443	KLF12	4	13	17	539.488
#444	NFATC2	4	19	23	544.936
#445	KLF15	4	14	18	193.648
#446	SIX3	4	17	21	2953.922
#447	PITX2	4	22	26	300.067
#448	SMAD1	4	11	15	77.214
#449	TLX2	4	15	19	192.826
#450	IRF1	4	13	17	740.867
#451	GBX1	4	17	21	1304.99
#452	ELF5	4	16	20	740.236
#453	NPAT	4	14	18	1005.332
#454	SRY	4	16	20	494.474
#455	NFATC1	4	15	19	499.149
#456	CDKN2A	4	16	20	1036.426
#457	ZNF85	4	16	20	1048.886
#458	ST18	4	16	20	391.564
#459	IKZF3	4	16	20	392.221
#460	OTX2	4	11	15	1756.914
#461	RARG	4	15	19	408.026
#462	BNC1	4	25	29	2234.152
#463	HNRNPAB	4	16	20	599.453
#464	ZNF157	4	13	17	718.917
#465	PGBD1	4	19	23	376.935
#466	FOSL1	4	16	20	421.353
#467	FOXB1	3	18	21	586.736
#468	HOXD10	3	23	26	495.549
#469	HIC1	3	17	20	186.659
#470	SCAND2	3	15	18	533.356
#471	IRF5	3	13	16	233.216
#472	POU2F3	3	19	22	424.322
#473	FOXD3	3	17	20	191.045
#474	ZNF483	3	16	19	400.584
#475	CRX	3	17	20	1463.331
#476	TCF4	3	18	21	714.583
#477	PTH	3	17	20	231.271
#478	RUNX1T1	3	21	24	695.535
#479	NR6A1	3	16	19	692.633
#480	HOXA2	3	16	19	975.488
#481	NANOGNB	3	19	22	358.913
#482	HOXD11	3	15	18	523.964
#483	IRX2	3	28	31	735.258
#484	BRD8	3	12	15	151.064
#485	ZSCAN5A	3	22	25	867.545
#486	TBX20	3	16	19	282.169
#487	ALS2CR8	2	16	18	435.931
#488	NKX2-1	2	23	25	235.884
#489	ARNTL2	2	21	23	512.362
#490	NCOR1	2	20	22	991.727
#491	TAF4	2	14	16	162.972
#492	EGR4	2	19	21	287.831
#493	SMAD4	2	16	18	185.292
#494	CBL	2	19	21	270.542
#495	ZNF175	2	14	16	99.559
#496	ZKSCAN3	2	10	12	233.908
#497	ESR2	2	21	23	146.789
#498	HES1	2	26	28	332.397
#499	NFYA	2	13	15	241.506
#500	NFE2	1	16	17	92.351