Hub Rank	Node	Children	Parents	Degree	Betweenness
#1	ELF4	90	3	93	603.294
#2	THRA	80	4	84	220.269
#3	RUNX2	77	4	81	397.479
#4	OLIG2	69	5	74	351.045
#5	KLF15	67	6	73	1302.264
#6	SALL2	63	6	69	288.907
#7	NKX3-1	62	11	73	552.378
#8	SMAD4	61	8	69	741.805
#9	SOX8	61	4	65	54.639
#10	BTG2	58	5	63	312.878
#11	WNT5A	58	12	70	408.801
#12	NFIA	57	6	63	667.543
#13	ZNF131	56	4	60	2304.31
#14	SOX2	55	9	64	2652.182
#15	TCF4	54	13	67	1110.198
#16	HMBOX1	53	6	59	496.886
#17	VDR	53	8	61	1005.687
#18	ZNF24	52	8	60	618.945
#19	IRF8	52	5	57	850.954
#20	SMAD3	51	8	59	907.715
#21	GAS7	50	15	65	613.441
#22	HES6	49	6	55	949.66
#23	CSRNP2	49	8	57	804.048
#24	FOSL1	49	9	58	259.032
#25	ZNF140	48	9	57	1595.267
#26	ZSCAN21	48	9	57	393.079
#27	ZNF91	46	12	58	814.526
#28	TFAM	46	9	55	771.967
#29	NFKB2	45	6	51	317.028
#30	CITED1	45	13	58	824.941
#31	PROX1	44	10	54	2435.489
#32	RARG	43	7	50	2389.446
#33	GABPB1	43	6	49	166.717
#34	PEG3	43	21	64	1856.216
#35	SUPT6H	42	10	52	1020.608
#36	LASS5	42	12	54	1447.055
#37	SOX15	41	12	53	421.515
#38	RCOR2	41	7	48	455.767
#39	ZKSCAN1	41	11	52	991.863
#40	NOTCH1	40	11	51	573.217
#41	SOX6	40	11	51	1352.881
#42	ETS1	39	12	51	2394.238
#43	TSC22D4	39	4	43	1719.757
#44	PCGF6	39	4	43	161.487
#45	BLZF1	39	10	49	1080.549
#46	PURB	38	14	52	1093.347
#47	ZNF263	38	12	50	793.217
#48	ZSCAN18	38	15	53	2068.804
#49	HEY1	38	12	50	1201.396
#50	CREB5	37	10	47	231.665
#51	MAFK	36	13	49	627.106
#52	SMAD6	36	17	53	656.518
#53	ATF1	35	9	44	261.888
#54	NEUROD1	35	12	47	5288.574
#55	ASCL1	34	11	45	168.176
#56	MYCN	34	13	47	8217.726
#57	TFAP2C	34	15	49	331.194
#58	FOXM1	33	7	40	1669.017
#59	GATAD2B	33	15	48	1502.045
#60	DLX1	33	18	51	3833.685
#61	TEAD4	33	16	49	1262.898
#62	ETV5	33	19	52	1400.264
#63	FOXC2	32	16	48	10949.716
#64	UHRF1	32	8	40	865.149
#65	SNAI2	32	11	43	886.985
#66	IRF1	32	13	45	3970.948
#67	MSC	31	17	48	1453.526
#68	ZEB1	31	12	43	438.703
#69	ETV1	30	20	50	820.922
#70	SOX1	30	8	38	1994.815
#71	TBX3	30	16	46	834.23
#72	ZNF33B	30	14	44	1481.951
#73	NFYB	30	10	40	1224.852
#74	E2F6	30	14	44	1327.482
#75	HOXB9	28	13	41	2386.912
#76	TCF19	28	9	37	821.865
#77	TFE3	28	12	40	685.328
#78	SOX9	28	15	43	936.074
#79	GATA6	27	17	44	753.373
#80	CREB1	27	10	37	1424.889
#81	RERE	27	17	44	2684.622
#82	NFIB	27	13	40	1953.072
#83	ARNTL2	26	22	48	2175.167
#84	TWIST2	26	15	41	1456.192
#85	TWIST1	26	14	40	1234.515
#86	CEBPA	26	18	44	3023.547
#87	ZNF287	26	17	43	1020.587
#88	NR2E1	26	14	40	1274.84
#89	HEY2	26	20	46	3228.907
#90	NFE2L2	25	14	39	4033.904
#91	FOSL2	25	16	41	973.864
#92	NR3C1	25	9	34	100.544
#93	TAF5	25	9	34	603.25
#94	ZNF281	25	12	37	1312.181
#95	ZNF3	25	15	40	1405.473
#96	SPEN	25	12	37	1198.113
#97	SMAD1	25	21	46	891.781
#98	LHX2	25	23	48	763.041
#99	RB1	24	15	39	3246.87
#100	STRN3	24	7	31	753.835
#101	TCF3	24	12	36	991.751
#102	LMO4	24	15	39	672.343
#103	TFCP2	24	12	36	834.5
#104	HOXB6	24	11	35	1392.86
#105	CUX1	24	12	36	630.92
#106	TGIF2	23	10	33	348.958
#107	POU6F1	23	13	36	1941.753
#108	EGR3	23	17	40	1542.549
#109	ZNF138	23	13	36	813.732
#110	FOXO6	23	11	34	1124.959
#111	VAX2	22	12	34	755.485
#112	ARID3A	22	11	33	2456.504
#113	TFDP2	22	12	34	389.945
#114	ZIC1	22	16	38	1367.714
#115	ZNF256	22	14	36	1901.146
#116	GCFC1	22	14	36	484.947
#117	NR2C1	22	14	36	1140.02
#118	ZNF33A	22	17	39	2183.588
#119	MYNN	21	6	27	552.067
#120	ATF3	21	14	35	445.641
#121	ETS2	21	16	37	456.189
#122	FLI1	21	25	46	2053.595
#123	TCF12	21	12	33	380.617
#124	HES5	21	13	34	1404.949
#125	DLX2	21	19	40	966.086
#126	GABPA	21	11	32	500.352
#127	KLF7	20	19	39	761.038
#128	FOS	20	17	37	690.494
#129	NFIX	20	13	33	717.611
#130	HMGA2	20	18	38	680.569
#131	TAF4B	19	13	32	777.121
#132	E2F8	19	9	28	836.02
#133	ARNT2	19	17	36	344.107
#134	FOXK1	19	13	32	1012.975
#135	ARNTL	19	19	38	3258.57
#136	SALL1	19	19	38	1537.19
#137	IRX3	19	18	37	536.094
#138	AFF4	19	11	30	635.986
#139	SOX11	19	24	43	2245.86
#140	E2F7	19	18	37	1846.563
#141	KDM5A	19	4	23	472.117
#142	MXD1	19	12	31	798.654
#143	ELK3	19	14	33	510.812
#144	ZNF85	19	11	30	306.759
#145	TARDBP	18	13	31	1420.948
#146	MTA3	18	12	30	880.518
#147	TSC22D1	18	15	33	646.916
#148	GATA3	18	24	42	1387.445
#149	HES1	18	21	39	943.275
#150	MYBL2	18	8	26	643.797
#151	ATF7	18	15	33	1945.692
#152	EN2	18	19	37	4373.437
#153	STAT5B	18	18	36	1220.507
#154	TSHZ3	18	20	38	3670.433
#155	ZNF117	18	13	31	393.936
#156	HSF2	18	14	32	1977.97
#157	CBFA2T2	18	13	31	1935.151
#158	CBFB	18	15	33	1612.378
#159	CNBP	17	12	29	1576.708
#160	ZNF92	17	7	24	798.469
#161	FOXN2	17	17	34	1555.557
#162	FOXO1	17	16	33	707.525
#163	MEF2A	17	13	30	1739.723
#164	TADA3	17	17	34	1004.297
#165	TBX5	17	14	31	1592.591
#166	E2F2	17	10	27	366.591
#167	FOXO3	17	17	34	2221.832
#168	ZFP36L2	17	17	34	671.313
#169	CREB3L2	17	14	31	401.97
#170	PBX1	17	24	41	708.315
#171	FOXF2	17	24	41	2335.417
#172	NFE2L3	17	18	35	1732.253
#173	POU3F2	17	21	38	1205.133
#174	PITX2	16	17	33	1219.253
#175	RFX5	16	21	37	1166.869
#176	MBD1	16	15	31	709.282
#177	PRRX1	16	22	38	996.179
#178	RUNX3	16	11	27	1975.43
#179	RUNX1	16	21	37	1839.5
#180	ZHX3	16	17	33	919.093
#181	DRAP1	16	17	33	854.493
#182	EGR2	16	22	38	908.41
#183	MEOX2	16	26	42	2752.185
#184	CNOT7	16	16	32	734.43
#185	USF2	16	14	30	469.221
#186	STAT1	16	19	35	957.127
#187	ATF6	15	15	30	1683.001
#188	ENO1	15	18	33	1290.518
#189	ZNF217	15	12	27	264.478
#190	C2orf3	15	16	31	644.397
#191	ETV6	15	12	27	289.433
#192	CREB3L1	15	23	38	625.994
#193	TFDP1	15	17	32	871.623
#194	MMP14	15	18	33	399.223
#195	NR2F2	15	30	45	5252.344
#196	CITED2	15	24	39	1747.869
#197	HMGB2	15	11	26	663.986
#198	CTBP1	15	18	33	3620.576
#199	NR4A2	15	12	27	1166.095
#200	MYCL1	15	16	31	1270.029
#201	SREBF2	15	20	35	3393.84
#202	FOXC1	15	17	32	953.66
#203	SP1	15	8	23	204.986
#204	HMX1	14	8	22	1942.329
#205	GATAD1	14	14	28	351.654
#206	TSC22D3	14	18	32	1157.417
#207	ETV4	14	13	27	1097.261
#208	PHTF1	14	22	36	1523.97
#209	IRX1	14	16	30	531.093
#210	ZNF232	14	17	31	419.615
#211	CSRNP3	14	16	30	661.01
#212	NFATC2	14	15	29	2717.332
#213	MLL	14	14	28	1151.577
#214	HOXA10	14	21	35	2883.766
#215	PKNOX2	14	22	36	2220.209
#216	AEBP1	14	16	30	1413.508
#217	ZBTB38	14	16	30	1321.905
#218	NFX1	14	20	34	1534.022
#219	NCOR1	14	18	32	1692.542
#220	TRPS1	14	21	35	982.507
#221	HMG20B	13	19	32	1917.841
#222	SLC2A4RG	13	15	28	2927.527
#223	PPARG	13	18	31	4535.553
#224	TCF7	13	15	28	943.256
#225	YEATS4	13	10	23	258.932
#226	NR2F6	13	15	28	1522.438
#227	NOLC1	13	13	26	427.859
#228	NPAS2	13	23	36	902.393
#229	TFAP2B	13	9	22	1551.68
#230	TCF7L1	13	14	27	1097.362
#231	SP4	13	16	29	671.672
#232	ARX	13	18	31	2484.594
#233	KLF5	13	20	33	950.548
#234	HOXB2	13	19	32	2260.488
#235	AHCTF1	13	16	29	671.228
#236	CBL	12	12	24	714.538
#237	FOXP1	12	17	29	2522.452
#238	FOXD1	12	21	33	3393.41
#239	HOXC10	12	23	35	2079.888
#240	ZNF367	12	6	18	266.676
#241	LASS6	12	24	36	2490.936
#242	FOXQ1	12	14	26	2662.496
#243	KLF12	12	18	30	3051.335
#244	HOXA4	12	12	24	1394.557
#245	E2F1	12	8	20	150.81
#246	PHF1	12	15	27	933.038
#247	TAF4	12	17	29	475.909
#248	ZNF133	12	9	21	807.36
#249	SMAD5	12	17	29	3504.732
#250	POU3F3	12	14	26	454.646
#251	JUN	11	22	33	1066.342
#252	SOX5	11	14	25	2216.695
#253	NFATC1	11	18	29	711.691
#254	FBXW7	11	14	25	313.054
#255	MEIS3P1	11	18	29	2033.174
#256	MGA	11	15	26	1044.641
#257	TCFL5	11	15	26	746.446
#258	RFXAP	11	15	26	433.93
#259	PCGF2	11	18	29	1272.596
#260	SMAD2	11	19	30	601.66
#261	POU4F1	11	16	27	1363.29
#262	CREBZF	11	15	26	266.949
#263	KLF3	11	20	31	2550.229
#264	ZNF397	11	15	26	332.424
#265	ZNF202	11	15	26	790.299
#266	ZFP37	11	16	27	1418.225
#267	SREBF1	11	18	29	914.87
#268	NKX3-2	11	13	24	596.643
#269	YY1	11	9	20	159.458
#270	E2F3	11	14	25	719.446
#271	TAF13	11	15	26	878.03
#272	HIRA	11	11	22	295.042
#273	RARB	11	12	23	290.628
#274	TFAP2A	11	19	30	1081.53
#275	SATB2	11	21	32	722.364
#276	ZFP90	10	20	30	943.159
#277	CEBPD	10	23	33	1343.105
#278	RELB	10	9	19	268.719
#279	E2F5	10	24	34	1884.786
#280	NR4A1	10	15	25	1023.611
#281	CSRNP1	10	13	23	1430.127
#282	HR	10	17	27	1608.52
#283	HIC1	10	12	22	195.678
#284	SIX1	10	19	29	2190.195
#285	ARNT	10	10	20	846.216
#286	CEBPB	10	11	21	145.902
#287	STAT2	10	16	26	518.331
#288	ZHX2	10	16	26	334.908
#289	ZNF134	10	17	27	2520.812
#290	JUNB	10	24	34	1725.739
#291	WT1	10	20	30	965.942
#292	ZKSCAN5	10	18	28	574.918
#293	TSHZ1	10	18	28	376.404
#294	FOSB	10	16	26	2774.098
#295	ZNF93	10	14	24	304.351
#296	RXRB	10	22	32	764.21
#297	HCLS1	10	11	21	837.015
#298	RORB	10	19	29	1864.263
#299	KLF10	10	18	28	918.009
#300	HOXB3	10	24	34	594.511
#301	ZNF83	10	21	31	1085.27
#302	FOXN3	10	21	31	1138.077
#303	MSX1	10	21	31	1452.399
#304	HOPX	10	28	38	1272.492
#305	HLF	10	21	31	1238.163
#306	AHR	10	21	31	683.653
#307	HOXB8	10	10	20	1518.035
#308	ZNF207	10	20	30	999.158
#309	BCL3	10	13	23	377.534
#310	SOX10	9	18	27	3499.912
#311	HOXA9	9	15	24	941.417
#312	TULP4	9	15	24	596.743
#313	MKX	9	13	22	474.685
#314	NFAT5	9	11	20	447.192
#315	ATF5	9	19	28	780.942
#316	SCML1	9	15	24	1442.803
#317	PLSCR1	9	25	34	1048.691
#318	HOXB7	9	19	28	592.971
#319	TAF5L	9	17	26	579.476
#320	NR4A3	9	12	21	959.112
#321	BCL6	9	19	28	1430.852
#322	DLX6	9	17	26	898.742
#323	HOXD10	9	21	30	1322.045
#324	PHF5A	9	19	28	2099.44
#325	ZNF268	9	19	28	1485.221
#326	KLF6	9	21	30	733.133
#327	SIM2	9	14	23	1538.672
#328	TBX2	9	21	30	2146.32
#329	FOXL1	9	9	18	1505.797
#330	NFIC	9	12	21	354.305
#331	MZF1	9	14	23	1053.1
#332	PAX3	9	22	31	1520.415
#333	HOXA2	9	17	26	811.977
#334	MEF2C	9	27	36	1227.008
#335	IRX5	9	19	28	2156.585
#336	LZTS1	9	31	40	1289.903
#337	CREB3	9	17	26	932.468
#338	RORA	9	19	28	950.554
#339	RCOR1	9	21	30	473.61
#340	ZNF277	8	14	22	246.05
#341	RUNX1T1	8	23	31	4403.993
#342	ALX1	8	16	24	1757.375
#343	C11orf9	8	17	25	818.619
#344	MYC	8	18	26	1364.172
#345	PBX3	8	17	25	1972.244
#346	HOXA7	8	20	28	3877.099
#347	HMGB1	8	13	21	2650.969
#348	GTF2I	8	17	25	520.658
#349	ZNF70	8	17	25	1697.879
#350	FUBP1	8	16	24	508.786
#351	PTTG1	8	10	18	215.481
#352	TRERF1	8	15	23	352.221
#353	ZXDA	8	12	20	330.616
#354	SOX4	8	18	26	618.286
#355	ZIC2	8	26	34	1676.862
#356	SOX12	8	19	27	614.054
#357	MEIS1	8	19	27	1984.193
#358	ZNF135	8	16	24	271.459
#359	CTNNB1	8	17	25	559.935
#360	HOXD13	8	13	21	967.515
#361	EGR1	8	20	28	636.344
#362	JUND	8	17	25	366.66
#363	ZEB2	7	22	29	666.162
#364	BACH1	7	23	30	921.94
#365	ZNF167	7	19	26	321.646
#366	SUPT4H1	7	13	20	468.247
#367	NR1H3	7	20	27	2295.482
#368	HMGA1	7	19	26	525.807
#369	MEOX1	7	14	21	1071.363
#370	NR3C2	7	23	30	1177.207
#371	RARA	7	15	22	828.075
#372	KLF4	7	27	34	762.031
#373	FOXJ1	7	19	26	993.095
#374	SIX4	7	17	24	1629.757
#375	KLF9	7	23	30	973.782
#376	MESP1	7	10	17	289.382
#377	C5orf41	7	23	30	1778.105
#378	ZXDC	7	14	21	499.906
#379	BCL11B	7	16	23	787.82
#380	BATF3	7	19	26	502.852
#381	DLX3	7	11	18	570.905
#382	PAX6	7	26	33	2712.042
#383	EN1	7	30	37	1824.585
#384	SATB1	7	24	31	2096.829
#385	NFIL3	7	17	24	1272.227
#386	SOX13	7	22	29	1908.385
#387	GLI2	7	15	22	252.876
#388	ZFHX4	6	18	24	442.296
#389	IRF9	6	19	25	1128.018
#390	HOXA5	6	21	27	1719.12
#391	JDP2	6	24	30	1295.769
#392	IRX2	6	12	18	505.015
#393	TBX1	6	22	28	1791.491
#394	TP53	6	12	18	1172.999
#395	ONECUT2	6	13	19	1293.429
#396	KLF11	6	18	24	1590.03
#397	ZFHX3	6	16	22	793.587
#398	BACH2	6	18	24	1417.304
#399	LHX8	6	18	24	519.39
#400	IRF7	6	14	20	514.165
#401	ARID4A	6	12	18	107.19
#402	STAT3	6	23	29	731.595
#403	XBP1	6	17	23	857.272
#404	ZHX1	6	16	22	472.783
#405	DBP	6	13	19	1831.566
#406	ZNF394	6	17	23	391.504
#407	PBX2	6	12	18	207.889
#408	TFEB	6	14	20	161.7
#409	LHX9	6	19	25	708.645
#410	TCF7L2	6	22	28	934.154
#411	ZNF323	5	23	28	716.808
#412	TEAD2	5	30	35	1000.113
#413	FOXF1	5	20	25	212.758
#414	CREM	5	25	30	527.676
#415	MSRB2	5	16	21	511.569
#416	NKX2-5	5	12	17	936.161
#417	RBCK1	5	19	24	317.487
#418	ELF2	5	18	23	289.752
#419	MAFB	5	33	38	1198.757
#420	GLI3	5	18	23	756.293
#421	FOXR2	5	14	19	1399.874
#422	SMAD9	5	25	30	490.604
#423	PRDM1	5	15	20	1280.896
#424	TRIM22	5	27	32	826.698
#425	TGIF1	5	18	23	366.659
#426	LEF1	5	27	32	523.721
#427	KDM5B	5	21	26	668.131
#428	ADNP	5	19	24	527.868
#429	RXRA	5	16	21	2480.67
#430	NR1D2	4	22	26	526.93
#431	FOXL2	4	20	24	285.723
#432	ZFPM2	4	31	35	4594.381
#433	NR1H4	4	11	15	314.707
#434	FOXG1	4	23	27	1445.514
#435	HOXA3	4	22	26	1015.838
#436	EBF1	4	26	30	6641.561
#437	PRRX2	4	11	15	470.952
#438	ZNF148	4	20	24	1511.794
#439	MEIS2	4	23	27	881.345
#440	BHLHE41	4	24	28	1274.717
#441	NFE2L1	4	20	24	252.189
#442	GTF2H2	4	22	26	853.547
#443	SNAPC5	4	21	25	1741.701
#444	GATAD2A	4	20	24	1442.527
#445	NFYA	4	24	28	436.568
#446	PLAG1	4	15	19	424.045
#447	CDKN2A	4	16	20	451.256
#448	DDIT3	4	21	25	587.128
#449	ZNF639	4	16	20	800.93
#450	MITF	4	19	23	171.408
#451	HOXA13	4	14	18	153.294
#452	SRF	4	20	24	638.178
#453	MSX2	4	17	21	164.384
#454	CSDA	4	22	26	639.93
#455	STAT6	4	20	24	563.938
#456	GTF2H4	4	15	19	181.002
#457	TBX15	4	18	22	779.727
#458	RCAN1	3	31	34	849.412
#459	FOXP2	3	19	22	576.14
#460	HOXA1	3	24	27	488.685
#461	RBPJ	3	16	19	96.283
#462	MECOM	3	18	21	218.424
#463	NKX2-1	3	13	16	871.472
#464	CREBL2	3	25	28	816.642
#465	MAFF	3	24	27	738.044
#466	C1orf85	3	17	20	262.538
#467	TEAD1	3	19	22	254.893
#468	HOXD11	3	16	19	422.697
#469	NR2F1	3	24	27	912.672
#470	NFYC	3	25	28	415.623
#471	BHLHE40	3	21	24	788.046
#472	MSL3	3	20	23	206.408
#473	FOXS1	3	14	17	240.042
#474	GLIS3	3	27	30	293.675
#475	ZNF75D	3	21	24	500.616
#476	EPAS1	3	38	41	334.718
#477	ZNF238	3	23	26	783.268
#478	THRB	3	25	28	594.615
#479	ZNF45	3	22	25	336.373
#480	PAX8	3	12	15	83.188
#481	ERF	3	19	22	279.195
#482	SOLH	3	24	27	529.228
#483	TCF25	3	20	23	498.821
#484	ELF1	3	22	25	1607.905
#485	IRF2	3	20	23	257.543
#486	TEAD3	3	24	27	633.084
#487	ZNF274	3	19	22	396.2
#488	GLIS2	2	23	25	737.666
#489	HOXD8	2	28	30	924.878
#490	ZFP36L1	2	20	22	630.805
#491	PITX1	2	24	26	845.944
#492	SOX7	2	20	22	667.742
#493	TSHZ2	1	24	25	73.149
#494	IRX4	1	11	12	28.488
#495	AR	1	22	23	379.496
#496	NR0B1	1	18	19	156.694
#497	MAF	1	22	23	62.281
#498	SLC30A9	1	18	19	29.03
#499	TEF	0	18	18	0
#500	KLF2	0	23	23	0