Hub Rank	Node	Children	Parents	Degree	Betweenness
#1	XBP1	52	1	53	1009.388
#2	FOXA1	43	1	44	11.769
#3	CREB3L2	42	2	44	1926.724
#4	TCEAL1	41	1	42	17.412
#5	ESR1	39	5	44	202.853
#6	GATA6	38	8	46	2065.55
#7	SCAND1	37	4	41	1637.277
#8	YBX1	36	7	43	412.25
#9	RBCK1	36	5	41	1392.932
#10	BTG2	35	5	40	1230.807
#11	FOXF2	35	7	42	709.849
#12	NFIA	33	12	45	855.974
#13	GATA3	32	6	38	193.133
#14	SIX5	31	5	36	1029.186
#15	TSHZ3	31	4	35	755.592
#16	DMTF1	30	1	31	36.547
#17	SNAI2	30	12	42	4837.261
#18	SALL2	29	10	39	730.103
#19	FOXN3	28	4	32	230.237
#20	AR	28	7	35	144.109
#21	TSC22D3	28	8	36	308.99
#22	FOXM1	28	2	30	898.738
#23	RUNX3	27	10	37	2669.116
#24	MTF1	27	6	33	1285.49
#25	SPDEF	27	6	33	497.591
#26	ZEB2	27	8	35	1238.667
#27	ZNF217	26	10	36	2344.694
#28	GCFC1	26	3	29	818.705
#29	PTTG1	26	4	30	291.064
#30	SOX12	26	6	32	3308.364
#31	ZGPAT	26	5	31	4877.928
#32	CREB3L4	25	14	39	4155.133
#33	ZNF91	25	9	34	4164.766
#34	CREBZF	25	5	30	1677.859
#35	ZNF207	25	4	29	934.934
#36	FOXO1	25	12	37	1706.906
#37	MYBL2	25	9	34	2326.208
#38	FOXC1	24	4	28	1674.299
#39	MEF2A	24	6	30	611.715
#40	TSHZ2	24	6	30	969.187
#41	HOXA10	24	4	28	113.122
#42	EGR2	24	7	31	2696.902
#43	EN1	23	13	36	1456.092
#44	TFE3	23	3	26	123.233
#45	MAX	23	3	26	450.984
#46	SOX6	23	10	33	778.134
#47	MEIS3P1	23	5	28	460.072
#48	ETV6	23	5	28	470.078
#49	E2F7	23	7	30	1044.495
#50	HOXB3	23	5	28	1140.701
#51	BHLHE41	23	13	36	2750.994
#52	LMO4	23	6	29	578.698
#53	IRX1	22	10	32	380.988
#54	ZNF45	22	8	30	1187.09
#55	NR2C1	22	8	30	2823.711
#56	CNOT8	22	2	24	670.011
#57	SOX8	22	9	31	303.616
#58	PEG3	22	14	36	3935.632
#59	BCL3	22	8	30	1340.802
#60	ZFHX4	21	8	29	645.947
#61	SOX9	21	10	31	3221.851
#62	SREBF1	21	11	32	2149.507
#63	E2F8	21	13	34	2142.29
#64	HOXA9	21	6	27	1777.413
#65	TAF4B	21	15	36	2301.066
#66	TCF4	21	1	22	474.659
#67	JUND	21	8	29	1934.671
#68	ZNF213	21	10	31	3917.483
#69	SP1	20	9	29	1219.768
#70	HES6	20	8	28	2398.853
#71	BACH2	20	11	31	1068.135
#72	MEIS2	20	8	28	700.162
#73	CSDA	20	13	33	3298.303
#74	CSRNP1	19	5	24	588.695
#75	ZNF628	19	7	26	463.15
#76	ATF6	19	8	27	1736.648
#77	FOSB	19	5	24	433.189
#78	HOXB7	19	13	32	2354.5
#79	IRF1	19	16	35	4273.745
#80	HMGB2	19	7	26	1875.671
#81	E2F3	19	9	28	767.311
#82	ZFP36L2	18	12	30	1573.291
#83	RELB	18	11	29	1881.548
#84	NFYC	18	8	26	925.232
#85	ZNF135	18	12	30	2085.641
#86	HOXC10	18	10	28	1960.986
#87	JUNB	18	6	24	1275.379
#88	ELF5	18	13	31	3407.162
#89	HSF1	18	10	28	2331.305
#90	IRF7	17	9	26	3177.817
#91	ZSCAN18	17	13	30	3288.677
#92	STAT1	17	9	26	1769.748
#93	MMP14	17	12	29	2094.952
#94	TAF5	17	12	29	1244.947
#95	FOXP2	17	6	23	2089.488
#96	EBF1	17	10	27	1626.068
#97	TCF7L1	17	8	25	1873.837
#98	GATAD2A	17	11	28	1835.7
#99	FLI1	17	9	26	982.531
#100	PA2G4	17	6	23	1244.874
#101	HIC1	17	13	30	1303.741
#102	TCF3	17	9	26	763.257
#103	HOXA3	16	10	26	997.826
#104	ZFPM2	16	7	23	818.316
#105	HCLS1	16	3	19	107.743
#106	ETV5	16	12	28	1481.326
#107	HOXA5	16	8	24	1087.111
#108	PRRX2	16	11	27	1603.293
#109	NFIL3	16	12	28	1352.35
#110	MEF2C	16	6	22	1247.468
#111	MBD1	16	6	22	1538.853
#112	FOS	16	8	24	613.763
#113	ZHX1	16	16	32	3378.769
#114	PBX1	16	15	31	1778.074
#115	RORA	16	10	26	959.076
#116	ATF3	15	6	21	954.118
#117	POU6F1	15	11	26	1699.544
#118	HOXB2	15	8	23	974.114
#119	ERG	15	9	24	971.74
#120	ZNF281	15	10	25	393.226
#121	THRB	15	15	30	2283.309
#122	HIF1A	15	12	27	3491.802
#123	STAT3	15	7	22	1446.803
#124	CDKN2A	15	11	26	577.381
#125	ZNF367	15	7	22	232.29
#126	IRF8	15	2	17	40.935
#127	ZFHX3	15	7	22	1738.916
#128	GTF2H2	15	7	22	1483.715
#129	ZRANB2	15	4	19	940.685
#130	IKZF1	15	1	16	44.973
#131	GAS7	15	12	27	617.231
#132	BATF	15	6	21	982.903
#133	EGR3	15	14	29	2107.329
#134	IRX2	15	15	30	4195.973
#135	KLF9	15	17	32	2231.88
#136	SMAD9	15	7	22	431.82
#137	NFATC1	14	9	23	599.245
#138	HLF	14	12	26	1140.946
#139	KLF10	14	13	27	2077.53
#140	ASCL2	14	18	32	2516.062
#141	STAT4	14	7	21	406.474
#142	EPAS1	14	9	23	452.275
#143	VAV1	14	8	22	1338.689
#144	BATF2	14	10	24	2371.022
#145	SOX13	14	16	30	1944.189
#146	AHR	14	17	31	4969.672
#147	HOPX	14	18	32	3408.359
#148	TEAD4	14	10	24	1186.632
#149	ZNF397	14	6	20	1477.346
#150	TRPS1	14	10	24	1583.319
#151	ZNF167	14	9	23	1077.489
#152	SATB2	14	8	22	3531.471
#153	HOXC9	14	11	25	1036.706
#154	LEF1	14	19	33	5838.398
#155	TBX5	14	6	20	306.514
#156	SRF	14	8	22	1559.809
#157	BRD8	14	14	28	2251.134
#158	SPI1	14	15	29	1850.079
#159	HOXC11	14	10	24	2262.914
#160	ZFPM1	14	7	21	1767.451
#161	ANKRD30A	14	11	25	730.918
#162	FOXN2	14	8	22	1030.589
#163	HR	13	12	25	595.104
#164	IRF9	13	10	23	1619.586
#165	HSF2	13	11	24	959.008
#166	IRF5	13	15	28	2396.461
#167	NR2F6	13	11	24	973.822
#168	RXRB	13	6	19	990.718
#169	CREB5	13	9	22	2501.402
#170	TWIST1	13	16	29	2002.227
#171	FOXO3	13	9	22	836.652
#172	MECOM	13	18	31	5724.795
#173	TRIM29	13	13	26	2692.245
#174	NFIB	13	10	23	1043.832
#175	TFAP2B	13	20	33	2663.396
#176	KLF3	13	11	24	1388.627
#177	ZNF639	13	11	24	1483.266
#178	CBFB	13	7	20	550.009
#179	NR2F1	13	7	20	530.513
#180	CSRNP3	13	12	25	1490.873
#181	ERF	13	8	21	930.472
#182	MEOX2	13	4	17	219.885
#183	SLC2A4RG	13	9	22	296.349
#184	TARDBP	13	11	24	2653.872
#185	HOXD8	13	9	22	3097.906
#186	UHRF1	13	12	25	847.831
#187	SOX7	12	13	25	1492.138
#188	ZNF500	12	11	23	886.375
#189	TFEC	12	6	18	399.464
#190	SOX10	12	8	20	461.434
#191	HOXA7	12	7	19	1343.547
#192	NCOR1	12	12	24	2482.245
#193	ZNF140	12	7	19	1028.675
#194	TWIST2	12	13	25	1165.917
#195	GLIS2	12	7	19	638.011
#196	ONECUT2	12	15	27	2431.073
#197	TSHZ1	12	16	28	5871.741
#198	HOXA1	12	12	24	1472.584
#199	PGR	12	15	27	1316.271
#200	ELF3	12	12	24	1250.048
#201	TCF19	12	12	24	1257.786
#202	ELK1	12	12	24	1611.603
#203	LHX6	12	7	19	344.429
#204	LASS2	12	16	28	2326.136
#205	ARNTL2	12	13	25	2270.209
#206	SIX4	12	11	23	1392.129
#207	ALS2CR8	12	8	20	1097.018
#208	GLIS3	12	17	29	2650.821
#209	FUBP1	12	5	17	129.475
#210	CREBL2	12	12	24	1757.85
#211	BHLHE40	11	8	19	973.742
#212	SIM2	11	14	25	1941.713
#213	KLF4	11	14	25	888.135
#214	NR3C1	11	11	22	805.905
#215	TBX3	11	15	26	1380.957
#216	ZNF33A	11	13	24	1406.268
#217	MEF2D	11	12	23	2536.651
#218	STAT2	11	6	17	728.007
#219	TCFL5	11	10	21	1029.381
#220	MEOX1	11	10	21	980.234
#221	PURB	11	13	24	3443.264
#222	RFX5	11	17	28	4480.847
#223	BCL11B	11	15	26	1488.91
#224	NR2E3	11	15	26	2247.448
#225	ETS2	11	19	30	1828.079
#226	YEATS4	11	12	23	3112.544
#227	GTF2I	11	9	20	1423.62
#228	PPARA	11	12	23	1808.3
#229	MAFB	10	12	22	1084.489
#230	ENO1	10	10	20	1591.688
#231	MAFF	10	8	18	490.568
#232	TRIM22	10	12	22	1162.184
#233	ATF2	10	12	22	522.937
#234	TBX10	10	5	15	651.732
#235	NFE2L3	10	9	19	592.063
#236	SATB1	10	12	22	1057.656
#237	MYCN	10	12	22	1141.313
#238	LASS6	10	13	23	1290.909
#239	NKX3-2	10	12	22	1895.006
#240	RUNX1T1	10	6	16	989.256
#241	E2F5	10	17	27	1880.018
#242	NR2F2	10	18	28	3295.997
#243	JUN	10	12	22	461.408
#244	HOXB5	10	5	15	437.584
#245	TRERF1	10	10	20	2209.799
#246	ZNF277	10	9	19	698.551
#247	SALL1	9	9	18	1303.99
#248	KLF7	9	13	22	1017.86
#249	TBX1	9	21	30	1957.762
#250	TRIM25	9	8	17	825.969
#251	TEAD2	9	16	25	2498.506
#252	HOXB4	9	10	19	655.544
#253	NFIX	9	15	24	1486.868
#254	SUPT6H	9	8	17	598.187
#255	ZNF232	9	11	20	1749.127
#256	USF1	9	13	22	798.695
#257	MTA3	9	13	22	1032.062
#258	SMAD1	9	10	19	449.84
#259	EMX1	9	6	15	476.06
#260	TFAP2A	9	13	22	1290.889
#261	ZIC2	9	10	19	1110.759
#262	SP140	9	8	17	680.393
#263	EHF	9	17	26	3289.904
#264	E2F2	9	12	21	1396.25
#265	HMGA1	9	14	23	3408.765
#266	ARNT2	9	16	25	1599.008
#267	ZIC1	9	12	21	2126.727
#268	ETV7	9	5	14	211.058
#269	ARNT	9	9	18	1446.968
#270	FOXP1	9	17	26	2810.533
#271	KLF6	9	8	17	836.036
#272	RORC	9	18	27	1093.328
#273	JDP2	9	14	23	896.466
#274	HOXB6	9	6	15	493.694
#275	RCAN1	9	15	24	2212.117
#276	HMBOX1	9	15	24	1885.486
#277	MSX1	9	13	22	363.216
#278	SMAD6	8	12	20	967.415
#279	ZNF238	8	17	25	1606.013
#280	FOXQ1	8	15	23	2479.507
#281	FOXD1	8	17	25	939.19
#282	EGR1	8	13	21	737.475
#283	HMX2	8	8	16	1181.072
#284	GATA2	8	16	24	1994.806
#285	RUNX1	8	12	20	1051.813
#286	CREB3L1	8	13	21	933.601
#287	MXD1	8	12	20	2944.048
#288	VAX2	8	7	15	593.469
#289	PLSCR1	8	13	21	2019.095
#290	PRDM1	8	13	21	956.821
#291	ATF6B	8	10	18	664.77
#292	RERE	8	9	17	487.777
#293	FOSL2	8	18	26	1042.652
#294	NR5A2	8	7	15	184.968
#295	ZSCAN16	8	18	26	1440.951
#296	KLF12	8	13	21	937.839
#297	SMAD3	8	10	18	674.247
#298	LCOR	8	11	19	1531.242
#299	BACH1	8	14	22	681.248
#300	SIM1	8	14	22	2743.261
#301	CUX1	8	14	22	1562.29
#302	KLF11	8	10	18	608.174
#303	MLL	7	8	15	435.401
#304	ZNF92	7	14	21	2150.033
#305	TCF7L2	7	11	18	1940.303
#306	GLI3	7	22	29	1764.849
#307	OVOL1	7	13	20	1636.189
#308	UBN1	7	15	22	866.418
#309	SOX5	7	13	20	370.458
#310	WT1	7	15	22	453.013
#311	SREBF2	7	16	23	990.987
#312	ZEB1	7	12	19	1392.241
#313	ZNF323	7	17	24	1725.844
#314	MSC	7	11	18	577.32
#315	WNT5A	7	15	22	873.128
#316	NFKB2	7	13	20	1378.844
#317	GABPA	7	15	22	598.677
#318	MSL3	7	11	18	781.995
#319	PCGF2	7	19	26	913.826
#320	TSC22D1	7	17	24	2425.793
#321	DLX6	7	7	14	133.101
#322	C5orf41	7	12	19	814.055
#323	SLC26A3	7	11	18	2320.143
#324	ZNF75D	7	19	26	832.081
#325	FOXK2	7	15	22	1162.14
#326	NR4A1	7	8	15	535.287
#327	TFCP2	7	9	16	991.927
#328	STRN3	6	11	17	301.422
#329	ZFP36L1	6	13	19	1039.996
#330	NFIC	6	13	19	544.917
#331	ZNF117	6	14	20	1111.982
#332	SIX2	6	17	23	1065.944
#333	TGIF2	6	14	20	577.835
#334	NR0B1	6	3	9	90.394
#335	NR1H3	6	16	22	1341.234
#336	CEBPB	6	12	18	913.084
#337	CBFA2T3	6	16	22	1540.013
#338	ZNF396	6	11	17	479.506
#339	MKX	6	10	16	922.688
#340	SOX2	6	5	11	164.315
#341	NFXL1	6	14	20	1464.927
#342	HOXC13	6	17	23	1556.578
#343	C11orf9	6	8	14	306.477
#344	PRRX1	6	17	23	990.477
#345	NR3C2	6	11	17	613.748
#346	EOMES	6	5	11	46.183
#347	FOXJ3	6	11	17	695.405
#348	NR1D2	6	17	23	1098.824
#349	FOXO6	6	12	18	1502.783
#350	TFEB	6	19	25	2172.92
#351	SMAD4	6	12	18	1005.484
#352	MSX2	6	10	16	700.007
#353	TEAD1	6	14	20	1618.055
#354	PITX1	6	19	25	2678.219
#355	TFCP2L1	6	18	24	704.92
#356	HIRA	6	13	19	1511.699
#357	KLF5	6	18	24	871.976
#358	FOXP4	6	11	17	314.511
#359	NPAS2	5	9	14	618.425
#360	HIF3A	5	7	12	633.486
#361	ETS1	5	15	20	664.663
#362	CEBPA	5	14	19	1021.284
#363	CBFA2T2	5	11	16	620.711
#364	SP3	5	17	22	1014.092
#365	AEBP1	5	14	19	725.325
#366	BTAF1	5	12	17	149.24
#367	ARNTL	5	12	17	551.777
#368	CITED2	5	11	16	786.012
#369	SOX18	5	17	22	1314.816
#370	ISX	5	5	10	215.183
#371	PPARG	5	13	18	295.068
#372	TGIF1	5	14	19	1140.295
#373	TULP4	5	16	21	2064.335
#374	GATAD2B	5	18	23	836.443
#375	NFATC2	5	12	17	490.572
#376	SOLH	5	12	17	601.658
#377	NFATC3	5	12	17	577.16
#378	HOXD4	5	13	18	862.535
#379	ZNF268	5	10	15	1066.313
#380	RUNX2	5	11	16	422.074
#381	ZNF93	5	16	21	1415.802
#382	IRF4	5	11	16	417.958
#383	L3MBTL4	5	14	19	481.145
#384	SPEN	5	11	16	290.795
#385	IRX4	5	12	17	939.511
#386	CNOT7	5	14	19	472.436
#387	MGA	5	10	15	427.103
#388	KLF2	5	16	21	429.069
#389	CREM	5	16	21	1115.288
#390	FOXF1	5	13	18	1158.052
#391	IRX5	5	13	18	438.918
#392	PGBD1	5	13	18	857.278
#393	RARA	5	12	17	914.273
#394	HOXB13	5	6	11	233.601
#395	CSRNP2	5	17	22	1139.053
#396	ZKSCAN1	5	15	20	996.655
#397	FOXS1	5	9	14	1176.045
#398	SOX17	5	10	15	251.019
#399	CUX2	5	7	12	295.296
#400	GRHL2	5	18	23	4027.381
#401	PBX2	5	14	19	1516.831
#402	NKX3-1	5	14	19	2075.63
#403	HEYL	5	9	14	536.813
#404	IRF6	5	14	19	1381.076
#405	HDX	5	13	18	866.364
#406	PAX7	5	7	12	277.176
#407	DBP	5	15	20	989.043
#408	ZNF70	5	9	14	898.311
#409	TBX19	5	9	14	250.543
#410	HOXA2	5	13	18	837.956
#411	TP53	4	16	20	1210.945
#412	ETV1	4	17	21	1158.888
#413	SIX1	4	19	23	907.97
#414	AFF4	4	18	22	1192.778
#415	HOXA11	4	9	13	928.129
#416	ELF4	4	15	19	474.523
#417	ZNF24	4	15	19	1270.624
#418	KDM5A	4	17	21	823.16
#419	SLC30A9	4	15	19	2098.312
#420	ZNF83	4	15	19	714.934
#421	PAX6	4	14	18	1193.661
#422	GTF2H4	4	14	18	1625.384
#423	HES1	4	13	17	1552.969
#424	TFDP2	4	13	17	1112.184
#425	ETV3	4	15	19	599.643
#426	ARX	4	7	11	218.272
#427	CTNNB1	4	21	25	626.256
#428	TFDP1	4	6	10	445.844
#429	GSC	4	12	16	544.109
#430	ZBTB38	4	15	19	721.615
#431	ZNF131	4	13	17	496.688
#432	SPIB	4	12	16	449.718
#433	ETV4	4	12	16	461.543
#434	MYC	3	14	17	268.378
#435	MZF1	3	13	16	165.007
#436	HEY2	3	19	22	1202.959
#437	LHX8	3	12	15	773.159
#438	RARB	3	9	12	315.846
#439	NANOG	3	20	23	567.184
#440	MITF	3	13	16	741.999
#441	ESX1	3	9	12	243.718
#442	ZNF85	3	17	20	2644.426
#443	SOX4	3	13	16	1224.74
#444	ESRRG	3	13	16	597.427
#445	GRHL3	3	13	16	2908.185
#446	PBX3	3	13	16	3283.985
#447	NFYA	3	8	11	251.675
#448	TSC22D4	3	7	10	552.917
#449	PHTF1	3	11	14	296.307
#450	HOXD1	3	10	13	212.154
#451	PROX1	3	11	14	205.898
#452	STAT6	3	13	16	380.986
#453	FOXI1	3	17	20	417.032
#454	IRX3	3	15	18	641.368
#455	POU2F3	3	13	16	671.211
#456	SOX11	3	17	20	1889.805
#457	TEF	3	16	19	280.552
#458	NR4A2	3	17	20	359.289
#459	CITED1	3	11	14	1166.861
#460	NANOGNB	3	13	16	735.656
#461	ZNF138	3	15	18	388.455
#462	TLX1	3	7	10	154.996
#463	CEBPD	3	15	18	988.921
#464	HOXB8	3	8	11	218.436
#465	MLLT10	3	16	19	528.776
#466	ZFP90	3	15	18	383.876
#467	SCAND3	3	8	11	691.402
#468	TFAP2C	3	14	17	1385.539
#469	FOXC2	2	14	16	122.799
#470	HOXA6	2	7	9	199.295
#471	HHEX	2	20	22	1329.717
#472	DLX2	2	20	22	1504.9
#473	NFAT5	2	13	15	220.048
#474	NR4A3	2	18	20	947.896
#475	C1orf85	2	12	14	321.414
#476	DLX1	2	13	15	808.908
#477	HEY1	2	12	14	88.688
#478	MEIS1	2	17	19	606.611
#479	MYCL1	2	14	16	640.29
#480	CTBP1	2	21	23	945.334
#481	FOSL1	2	17	19	931.443
#482	SCML1	1	17	18	239.542
#483	TCF12	1	12	13	47.429
#484	HMGA2	1	16	17	828.247
#485	ATF5	1	14	15	49.054
#486	MESP1	1	16	17	81.263
#487	MNX1	1	15	16	592.204
#488	TP63	1	15	16	296.184
#489	ZHX2	1	12	13	144.575
#490	TCF25	1	13	14	123.78
#491	SOX15	1	12	13	46.244
#492	BCL6	1	18	19	176.86
#493	DLX3	1	13	14	29.158
#494	PURA	1	17	18	121.824
#495	REL	0	11	11	0
#496	EGR4	0	14	14	0
#497	MAF	0	16	16	0
#498	SIX3	0	9	9	0
#499	HOXD10	0	10	10	0
#500	ZNF165	0	18	18	0