Hub Rank	Node	Children	Parents	Degree	Betweenness
#1	MITF	89	7	96	984.831
#2	MECOM	86	3	89	451.849
#3	AHR	73	7	80	2167.367
#4	PBX3	72	6	78	1711.329
#5	HOXB3	65	7	72	1808.587
#6	SOX7	58	2	60	1559.22
#7	SIX1	55	4	59	1628.111
#8	ETS2	51	10	61	3961.941
#9	TFAP2A	51	7	58	5639.414
#10	HMGA2	47	10	57	2677.499
#11	KLF4	47	10	57	4482.037
#12	HOXB5	46	3	49	196.246
#13	DLX1	45	9	54	3206.003
#14	HOXA3	45	2	47	2758.605
#15	HOXB2	44	8	52	1618.966
#16	IRF6	43	3	46	434.126
#17	FOXP1	40	9	49	22161.411
#18	HOXA1	39	2	41	147.437
#19	FOXC1	38	9	47	4026.145
#20	JUNB	38	12	50	2878.475
#21	HOXC9	38	4	42	656.154
#22	ZEB1	37	13	50	3036.771
#23	ZNF238	37	10	47	1576.027
#24	ZSCAN18	36	6	42	6188.504
#25	HOXB6	35	6	41	3626.619
#26	NR2F2	35	11	46	4692.804
#27	SCML2	34	9	43	2577.347
#28	SMAD3	34	4	38	66.664
#29	TRIM29	34	9	43	1558.131
#30	ZHX1	31	6	37	8130.947
#31	ZNF148	30	12	42	17068.137
#32	ZSCAN21	29	9	38	1953.855
#33	TFAP2C	29	9	38	1320.953
#34	TSHZ1	29	12	41	5008.566
#35	ETS1	28	8	36	718.467
#36	MEIS1	28	11	39	3090.149
#37	GLIS3	28	8	36	1257.782
#38	RXRA	27	8	35	2428.521
#39	TRPS1	27	2	29	33.606
#40	ZFP90	27	11	38	4680.444
#41	TP63	27	6	33	1602.221
#42	DLX6	26	11	37	3135.161
#43	MTA3	26	8	34	1815.895
#44	CSRNP2	25	7	32	545.677
#45	E2F5	25	12	37	1629.166
#46	KLF5	25	12	37	770.296
#47	ZNF92	25	10	35	2975.951
#48	ZNF91	24	10	34	3081.575
#49	ZIC2	24	13	37	3466.337
#50	PLSCR1	24	8	32	1226.583
#51	HOXB9	24	10	34	1230.531
#52	ARNTL2	23	14	37	4521.976
#53	HEY1	23	10	33	1618.622
#54	FOXQ1	23	8	31	396.55
#55	PURA	23	10	33	1694.193
#56	NFIL3	23	15	38	4515.442
#57	EPAS1	23	9	32	859.915
#58	GLI3	22	7	29	1448.82
#59	NFIA	22	12	34	6382.169
#60	CDKN2A	21	8	29	639.306
#61	GATA6	21	7	28	114.155
#62	AHCTF1	21	14	35	1368.182
#63	FOXD1	21	11	32	4994.676
#64	C11orf9	21	7	28	1965.618
#65	FOSL2	21	13	34	823.558
#66	RUNX2	21	7	28	6325.546
#67	HOXA5	20	8	28	2198.644
#68	ETV1	20	6	26	396.578
#69	ISL1	20	13	33	1925.431
#70	MEOX2	20	5	25	368.343
#71	GRHL2	20	6	26	1371.735
#72	USF1	20	8	28	955.311
#73	FOXL2	20	12	32	1306.723
#74	NKX3-1	19	12	31	2650.285
#75	SIX3	19	11	30	555.869
#76	NR3C1	19	12	31	1102.178
#77	BHLHE41	19	5	24	660.679
#78	ZNF394	19	4	23	671.842
#79	DMTF1	18	11	29	562.358
#80	ZNF3	18	11	29	985.246
#81	NFIB	18	8	26	1549.234
#82	ZNF83	18	3	21	375.348
#83	ZNF643	18	13	31	517.41
#84	BARX1	18	8	26	831.56
#85	POU5F1B	18	6	24	1004.235
#86	SIX4	18	8	26	1617.909
#87	TCF12	18	6	24	642.676
#88	FOXA1	17	3	20	280.64
#89	FOXN2	17	11	28	448.375
#90	ELF4	17	8	25	1046.3
#91	TWIST2	17	9	26	1369.701
#92	ZKSCAN5	17	7	24	2615.382
#93	RCAN1	17	11	28	3886.775
#94	OVOL1	17	9	26	650.216
#95	MAFK	17	19	36	1787.009
#96	GTF2H2	16	10	26	1875.783
#97	FOXO1	16	8	24	734.765
#98	LEF1	16	8	24	1036.894
#99	BTG2	16	15	31	5315.82
#100	ZFP36L2	16	14	30	7047.009
#101	ZNF85	16	7	23	490.357
#102	EHF	16	12	28	1098.771
#103	HNRNPAB	16	8	24	2165.02
#104	CTCF	15	7	22	913.154
#105	HNF1B	15	9	24	493.638
#106	DLX2	15	9	24	841.519
#107	HOXC10	15	11	26	824.659
#108	SOX17	15	4	19	329.777
#109	RBCK1	15	9	24	2439.744
#110	ALS2CR8	15	9	24	19014.188
#111	PITX2	15	8	23	1047.922
#112	VDR	15	10	25	1695.105
#113	CREM	15	15	30	1431.371
#114	RERE	15	10	25	806.281
#115	SALL2	15	11	26	696.443
#116	MTA2	15	13	28	2211.207
#117	BCL6	15	11	26	837.613
#118	JUND	15	10	25	4868.381
#119	MNX1	15	8	23	3141.362
#120	HMGA1	14	16	30	1621.999
#121	SP1	14	8	22	2720.662
#122	HOXA13	14	14	28	1294.057
#123	MYBL2	14	8	22	2992.875
#124	ARID3A	14	15	29	1246.787
#125	PITX1	14	11	25	253.923
#126	NFX1	14	11	25	5387.273
#127	CSRNP3	14	3	17	112.826
#128	HR	14	3	17	227.799
#129	RARG	14	9	23	1778.149
#130	MLLT10	14	12	26	2756.86
#131	ELK3	13	18	31	7665.978
#132	PAX7	13	10	23	466.464
#133	PAX8	13	8	21	2522.334
#134	TP53	13	10	23	1641.496
#135	HOXB7	13	12	25	664.362
#136	IRX2	13	4	17	90.776
#137	HOXA9	13	4	17	243.774
#138	SOX9	13	13	26	5821.613
#139	ISL2	13	12	25	1143.167
#140	C1orf85	13	13	26	458.943
#141	PKNOX1	13	12	25	427.272
#142	E2F6	13	12	25	1571.632
#143	RXRB	13	8	21	3177.233
#144	HOXA2	13	15	28	4530.459
#145	ESR1	13	6	19	373.973
#146	GATAD2A	13	10	23	5409.079
#147	BCL11B	12	4	16	67.002
#148	LASS6	12	10	22	1624.514
#149	LHX6	12	11	23	1574.206
#150	FUBP1	12	15	27	2740.329
#151	SCML1	12	17	29	4756.187
#152	C5orf41	12	12	24	3771.809
#153	IRF7	12	6	18	434.083
#154	ELF1	12	12	24	667.317
#155	CTBP1	12	14	26	2450.72
#156	NR1D2	12	12	24	869.402
#157	HCLS1	12	10	22	1749.691
#158	LHX2	12	13	25	5345.222
#159	SATB2	12	11	23	2356.496
#160	ZBTB38	12	14	26	3083.92
#161	BHLHE40	12	18	30	2667.144
#162	HHEX	12	15	27	1841.024
#163	CNOT7	11	14	25	3377.546
#164	GATAD1	11	10	21	1364.124
#165	ZNF33A	11	10	21	525.437
#166	SLC2A4RG	11	9	20	4003.424
#167	SMAD1	11	10	21	4301.397
#168	RUNX1	11	10	21	635.74
#169	UBP1	11	10	21	255.97
#170	ALX1	11	10	21	827.236
#171	SMAD5	11	14	25	2249.322
#172	ZSCAN16	11	10	21	403.271
#173	TAF5L	11	11	22	799.686
#174	ESRRG	11	9	20	2133.815
#175	SIX2	11	13	24	651.162
#176	MEIS3P1	11	13	24	494.939
#177	ZFHX3	11	10	21	377.36
#178	SNAI2	11	11	22	665.774
#179	NFE2L3	11	6	17	1208.888
#180	ZNF138	11	19	30	2543.41
#181	RB1	11	7	18	757.514
#182	ZNF71	11	7	18	608.764
#183	FOXM1	11	7	18	3021.812
#184	TCF25	10	8	18	1842.308
#185	FOXF2	10	10	20	3944.392
#186	ZNF140	10	14	24	2389.782
#187	HMG20A	10	6	16	1137.295
#188	ZNF19	10	9	19	1391.925
#189	MAX	10	10	20	1913.657
#190	HOXA7	10	6	16	109.721
#191	HES1	10	16	26	1357.576
#192	LASS2	10	8	18	254.559
#193	YY1	10	14	24	1497.82
#194	FOXK2	10	7	17	3112.762
#195	IRX4	10	8	18	717.698
#196	HNF4G	10	12	22	649.198
#197	BNC1	10	6	16	3600.102
#198	TRERF1	10	17	27	3252.202
#199	ELK4	10	9	19	369.577
#200	SMAD4	10	13	23	8562.719
#201	KLF7	10	14	24	3974.953
#202	TFAM	10	13	23	5889.681
#203	MSX2	10	11	21	1041.578
#204	NFIX	10	11	21	2480.911
#205	HOXA11	10	11	21	769.071
#206	HOXA10	10	8	18	182.808
#207	DDIT3	9	8	17	1431.051
#208	AATF	9	11	20	3135.378
#209	SOX12	9	9	18	778.986
#210	TBX2	9	5	14	3954.003
#211	MEIS2	9	11	20	2626.138
#212	SOX15	9	3	12	278.989
#213	CTNNB1	9	14	23	1184.464
#214	CITED2	9	10	19	1257.423
#215	RBPJ	9	11	20	1430.947
#216	TCFL5	9	15	24	759.542
#217	ZHX2	9	16	25	3048.725
#218	STRN3	9	10	19	717.963
#219	PRRX2	9	9	18	247.591
#220	ATF6	9	11	20	967.964
#221	NR6A1	9	9	18	367.36
#222	TSC22D2	9	11	20	712.267
#223	SCAND3	9	16	25	944.526
#224	ESRRA	9	13	22	778.787
#225	ZNF175	9	10	19	1011.263
#226	TGIF2	9	14	23	1267.892
#227	PPARG	8	13	21	547.374
#228	RFXANK	8	9	17	23384.112
#229	ADNP	8	10	18	357.919
#230	NFYB	8	12	20	1472.706
#231	RFX5	8	13	21	436.468
#232	PBX1	8	12	20	2835.293
#233	ETV5	8	9	17	1402.589
#234	NFYC	8	17	25	4080.473
#235	MEF2A	8	17	25	5525.286
#236	TSC22D3	8	13	21	1846.861
#237	TCF7L2	8	16	24	767.49
#238	ELF3	8	9	17	257.538
#239	ADNP2	8	12	20	3173.852
#240	ASCL2	8	10	18	1215.545
#241	LMO4	8	18	26	4812.462
#242	ZNF189	8	14	22	1110.876
#243	TFE3	8	12	20	1291.502
#244	FOXO3	8	12	20	1167.171
#245	ZNF33B	8	16	24	1586.909
#246	TAF13	8	10	18	241.738
#247	IRF1	8	13	21	845.628
#248	MAFF	8	11	19	965.587
#249	GTF2I	8	9	17	375.565
#250	NFXL1	8	13	21	2674.657
#251	ZNF167	7	12	19	1415.547
#252	TFDP1	7	14	21	1371.468
#253	HOXD10	7	11	18	506.047
#254	ATF3	7	12	19	2807.027
#255	ATF7	7	13	20	1513.901
#256	STAT3	7	15	22	1346.866
#257	FOXE1	7	7	14	506.98
#258	DRAP1	7	11	18	413.645
#259	ZNF131	7	11	18	744.54
#260	ZNF498	7	11	18	806.573
#261	ZFHX4	7	9	16	526.962
#262	EGR3	7	8	15	26533.439
#263	TAF12	7	12	19	829.342
#264	ZNF268	7	13	20	828.214
#265	NFAT5	7	14	21	348.587
#266	MNT	7	13	20	964.359
#267	LCOR	7	8	15	1260.837
#268	NPAT	7	9	16	317.634
#269	ZXDA	7	9	16	213.919
#270	MLL	7	13	20	501.63
#271	RUNX3	7	12	19	3618.962
#272	CREB3L2	7	10	17	1162.526
#273	PHTF1	7	13	20	799.269
#274	ZNF217	7	14	21	729.209
#275	ATF5	7	11	18	1323.045
#276	SALL1	7	6	13	381.99
#277	SREBF2	7	12	19	1808.946
#278	GABPB1	7	13	20	3769.945
#279	TBX1	6	7	13	505.934
#280	PRDM2	6	11	17	469.958
#281	ATF1	6	16	22	1382.381
#282	GTF2H4	6	11	17	730.546
#283	XBP1	6	11	17	1046.397
#284	TEAD4	6	9	15	558.254
#285	NPAS2	6	11	17	1018.252
#286	ZNF639	6	11	17	1556.839
#287	MEF2D	6	13	19	383.61
#288	ATF2	6	13	19	1142.429
#289	KLF10	6	16	22	299.451
#290	NFKB2	6	11	17	1050.446
#291	TSC22D1	6	14	20	102.942
#292	ZNF397	6	9	15	1120.653
#293	KDM5B	6	15	21	1067.778
#294	HOXB4	6	15	21	894.774
#295	TFEC	6	5	11	209.214
#296	IRX5	6	15	21	2277.413
#297	KLF9	6	12	18	6692.642
#298	IRF2	6	14	20	1698.382
#299	ZNF134	6	11	17	1884.193
#300	TAF1B	6	9	15	764.303
#301	KLF3	6	11	17	586.673
#302	TAF4	6	10	16	1390.296
#303	IRX3	6	12	18	1155.284
#304	CBFB	6	13	19	582.86
#305	ZC3H8	6	8	14	1211.561
#306	ZFP37	6	17	23	595.635
#307	NR2C1	6	13	19	1065.826
#308	ZNF187	6	13	19	419.021
#309	TLX3	6	10	16	422.679
#310	TBX3	6	7	13	3957.864
#311	TAF4B	6	14	20	469.657
#312	MTA1	6	10	16	740.949
#313	GCFC1	5	12	17	3075.264
#314	SOX2	5	20	25	2708.507
#315	TWIST1	5	15	20	1262.019
#316	ZNF165	5	13	18	7175.247
#317	MXD1	5	14	19	333.88
#318	GLI2	5	13	18	1498.19
#319	PLAG1	5	17	22	2202.176
#320	MSX1	5	19	24	711.704
#321	TAF5	5	6	11	188.295
#322	ETV6	5	14	19	1089.885
#323	KLF12	5	10	15	664.398
#324	TFDP2	5	12	17	770.596
#325	LHX1	5	10	15	735.001
#326	HSF2	5	11	16	2854.166
#327	ZNF24	5	9	14	1542.51
#328	ONECUT1	5	7	12	48.923
#329	E2F3	5	13	18	512.62
#330	VAV1	5	11	16	1531.973
#331	PPARA	5	12	17	1715.567
#332	PLAGL2	5	11	16	262.675
#333	BACH1	5	14	19	1267.435
#334	SREBF1	5	9	14	3994.357
#335	HOXD11	5	8	13	274.343
#336	NOTCH1	5	12	17	9357.241
#337	ZNF496	5	6	11	437.696
#338	HDX	5	12	17	1265.142
#339	HMGB2	5	17	22	2320.485
#340	ZSCAN29	5	9	14	1241.496
#341	PCGF6	5	15	20	654.482
#342	UHRF1	4	17	21	3824.433
#343	GRHL3	4	10	14	1324.039
#344	KLF15	4	13	17	667.991
#345	PAX6	4	13	17	256.514
#346	ZNF37A	4	8	12	640.026
#347	ARNT	4	10	14	920.003
#348	PTTG1	4	12	16	934.828
#349	NR3C2	4	11	15	640.883
#350	JUN	4	16	20	5078.386
#351	SLC30A9	4	13	17	1820.78
#352	ZNF193	4	13	17	625.449
#353	TGIF1	4	11	15	442.76
#354	WT1	4	11	15	4735.931
#355	FOXG1	4	7	11	938.31
#356	FOSL1	4	15	19	1156.016
#357	NR2F1	4	10	14	136.515
#358	SUPT6H	4	12	16	2783.695
#359	WNT5A	4	15	19	1569.206
#360	LHX8	4	7	11	260.586
#361	MSRB2	4	13	17	674.559
#362	BCL3	4	14	18	3136.533
#363	RELA	4	12	16	1068.626
#364	HOPX	4	12	16	172.519
#365	ENO1	4	10	14	341.904
#366	RARB	4	13	17	332.515
#367	CLOCK	4	14	18	648.901
#368	EOMES	4	9	13	526.54
#369	THRB	4	14	18	858.675
#370	ARNT2	4	11	15	118.225
#371	NCOR1	4	13	17	1554.303
#372	HOXD4	4	10	14	145.447
#373	NKX2-1	4	10	14	166.573
#374	ZNF434	4	10	14	651.924
#375	HMG20B	4	10	14	1417.393
#376	ZNF93	4	15	19	248.83
#377	BTAF1	4	12	16	193.833
#378	TEAD2	4	11	15	736.212
#379	ZNF232	4	16	20	801.499
#380	GATAD2B	4	9	13	334.621
#381	TCF19	4	9	13	1070.976
#382	REL	3	11	14	870.601
#383	SOX8	3	11	14	563.943
#384	HEYL	3	12	15	753.063
#385	GTF2H3	3	14	17	3064.963
#386	HOXD8	3	16	19	8255.573
#387	CUX1	3	15	18	343.354
#388	ZNF256	3	11	14	2206.494
#389	MYCL1	3	14	17	2305.946
#390	C2orf3	3	14	17	140.366
#391	GATA5	3	10	13	256.461
#392	ZNF281	3	12	15	369.397
#393	YEATS4	3	15	18	315.512
#394	ZNF277	3	12	15	821.74
#395	MAFB	3	11	14	273.831
#396	TEF	3	10	13	73.603
#397	SMAD6	3	16	19	1501.688
#398	HOXB8	3	14	17	441.689
#399	FBXW7	3	11	14	188.984
#400	NFE2L1	3	12	15	665.141
#401	LZTS1	3	12	15	552.154
#402	SATB1	3	13	16	124.733
#403	AFF1	3	20	23	219.703
#404	CEBPB	3	15	18	286.724
#405	SOX13	3	12	15	235.032
#406	EGR1	3	13	16	303.477
#407	NR4A3	3	12	15	501.003
#408	IRF9	3	17	20	1547.257
#409	ZNF449	3	10	13	228.043
#410	MEOX1	3	13	16	737.789
#411	SIX5	3	13	16	1129.524
#412	CREBL2	3	11	14	314.764
#413	MYNN	3	15	18	1741.71
#414	ATF4	3	12	15	1756.759
#415	HIF3A	3	14	17	874.334
#416	SRF	3	11	14	145.217
#417	GLIS2	3	11	14	166.301
#418	ZFP36L1	3	11	14	1064.448
#419	BLZF1	3	18	21	2660.316
#420	CSDA	2	10	12	41.635
#421	E2F7	2	13	15	1734.157
#422	TARDBP	2	15	17	1358.926
#423	HESX1	2	11	13	1474.508
#424	FOXR2	2	5	7	424.307
#425	PHF5A	2	11	13	2416.337
#426	HMGB1	2	10	12	93.172
#427	TEAD1	2	15	17	822.974
#428	NFE2L2	2	12	14	1212.587
#429	STAT1	2	14	16	167.578
#430	SIN3A	2	15	17	1319.665
#431	SP3	2	6	8	128.839
#432	HES6	2	12	14	205.587
#433	TCF4	2	9	11	5669.402
#434	ARID4A	2	11	13	80.941
#435	SOLH	2	14	16	20866.485
#436	ZNF117	2	11	13	141.994
#437	HOXC13	2	9	11	70.447
#438	PRDM1	2	15	17	61.188
#439	RFXAP	2	12	14	69.224
#440	ZNF323	2	13	15	183.641
#441	ZNF367	2	18	20	268.613
#442	NOLC1	2	18	20	2157.309
#443	ETV4	2	19	21	175.126
#444	MKX	2	14	16	11414.564
#445	ZEB2	2	6	8	128.802
#446	TRIM22	2	16	18	283.329
#447	DLX3	2	11	13	30.093
#448	MGA	2	13	15	880.904
#449	FLI1	2	3	5	348.061
#450	GATA3	2	13	15	527.338
#451	MAF	2	6	8	417.441
#452	ARX	2	12	14	25.51
#453	E2F8	2	13	15	827.411
#454	STAT2	2	10	12	114.081
#455	NR1H3	1	8	9	33.877
#456	HMBOX1	1	12	13	49.403
#457	RARA	1	16	17	94.379
#458	KLF6	1	15	16	1076.676
#459	GATA4	1	9	10	9.679
#460	SMAD2	1	16	17	86.593
#461	FOXF1	1	6	7	167.358
#462	NR4A2	1	13	14	94.051
#463	KLF2	1	10	11	568.277
#464	CREBBP	1	15	16	128.053
#465	SCAND1	1	13	14	36.792
#466	HOXD9	1	13	14	1075.193
#467	ZKSCAN1	1	16	17	1317.294
#468	TRIM25	1	10	11	585.215
#469	PURB	1	14	15	594.76
#470	DBP	1	20	21	197.486
#471	SPEN	1	18	19	1207.182
#472	AFF4	1	11	12	557.424
#473	PA2G4	1	13	14	289.326
#474	CCRN4L	1	18	19	193.384
#475	TRIM28	1	16	17	2713.595
#476	HEY2	1	6	7	31.299
#477	ARNTL	1	9	10	16.62
#478	CREBZF	1	11	12	67.511
#479	SOX4	1	11	12	45.403
#480	ZNF274	1	11	12	2881.995
#481	KLF11	1	17	18	51.704
#482	TULP4	1	15	16	1801.876
#483	FOXN3	1	9	10	744.362
#484	ZSCAN12	1	10	11	334.97
#485	PPARD	1	14	15	741.257
#486	NFYA	1	9	10	274.93
#487	ZNF207	0	13	13	0
#488	ZNF70	0	11	11	0
#489	GATA2	0	9	9	0
#490	TCF7L1	0	14	14	0
#491	SIM1	0	4	4	0
#492	CREB3L4	0	11	11	0
#493	FOXP2	0	10	10	0
#494	JDP2	0	16	16	0
#495	CEBPD	0	17	17	0
#496	STAT4	0	11	11	0
#497	FOS	0	15	15	0
#498	TCEAL1	0	10	10	0
#499	MYC	0	12	12	0
#500	SMAD9	0	23	23	0