Hub Rank	Node	Children	Parents	Degree	Betweenness
#1	HOPX	51	5	56	4043.063
#2	CEBPA	39	8	47	2340.029
#3	SOX10	38	3	41	395.725
#4	GATA3	36	5	41	5228.296
#5	ARNT2	35	4	39	1737.564
#6	SOX17	34	2	36	97.876
#7	HOXB1	33	3	36	1769.045
#8	NFIB	33	5	38	1832.946
#9	RUNX1T1	32	8	40	1808.995
#10	TSHZ2	31	5	36	971.457
#11	ONECUT1	31	7	38	1402.334
#12	ETS2	31	6	37	665.576
#13	HOXB8	30	4	34	1182.253
#14	EPAS1	30	4	34	311.183
#15	IRF4	29	9	38	1529.387
#16	EBF1	29	1	30	159.261
#17	SALL2	27	7	34	3327.48
#18	MITF	27	7	34	1534.41
#19	FLI1	27	6	33	434.014
#20	CBFA2T3	27	7	34	2294.862
#21	IRF7	26	4	30	572.129
#22	NKX1-1	26	5	31	630.476
#23	ZNF138	26	6	32	1893.011
#24	DLX1	25	15	40	2080.256
#25	ZNF91	25	8	33	3884.754
#26	PAX3	25	6	31	508.218
#27	PEG3	24	8	32	5435.828
#28	FOXM1	24	1	25	53.166
#29	GRHL3	24	7	31	787.349
#30	NFIA	24	8	32	994.415
#31	ALX1	24	8	32	866.518
#32	TP63	24	5	29	278.033
#33	SOX7	24	6	30	662.451
#34	GRHL2	23	3	26	486.635
#35	FOSL1	23	7	30	1614.663
#36	BTG2	23	8	31	4973.539
#37	PTTG1	23	6	29	388.341
#38	LEF1	23	9	32	930.172
#39	SOX30	23	4	27	1017.041
#40	MEOX1	22	8	30	1369.423
#41	HCLS1	22	3	25	131.393
#42	ZNF135	22	9	31	3579.244
#43	VAV1	21	2	23	829.179
#44	KLF5	21	6	27	1957.543
#45	SP140	21	3	24	128.408
#46	FOXK1	21	6	27	544.946
#47	AR	21	8	29	515.595
#48	KLF2	21	8	29	606.452
#49	EHF	21	9	30	1562.065
#50	HOXB7	21	6	27	3662.764
#51	HOXB5	21	2	23	213.997
#52	BATF	20	11	31	3649.925
#53	TSHZ3	20	5	25	1529.622
#54	SOX13	20	11	31	905.762
#55	ZNF93	20	12	32	3668.919
#56	TRIM29	20	5	25	377.947
#57	ETV5	20	6	26	589.887
#58	E2F7	20	7	27	1050.36
#59	AHCTF1	20	8	28	4054.368
#60	ATOH1	20	7	27	366.702
#61	DLX3	19	5	24	185.759
#62	UHRF1	19	3	22	600.567
#63	FOXD3	19	13	32	1033.118
#64	CEBPE	19	11	30	3826.861
#65	ZFP37	19	11	30	1692.282
#66	TCF4	19	6	25	1514.699
#67	IRX2	19	9	28	1015.853
#68	HOXA2	19	8	27	1849.473
#69	TBX15	19	12	31	1238.646
#70	BATF3	19	13	32	4343.933
#71	HIF1A	19	3	22	624.663
#72	EN1	19	11	30	875.089
#73	BCL11B	18	12	30	2156.736
#74	PLAG1	18	12	30	2228.882
#75	IRF8	18	4	22	512.679
#76	TRIM22	18	6	24	480.371
#77	NR2E1	18	7	25	1562.724
#78	ETV4	18	6	24	217.855
#79	SPI1	18	5	23	364.463
#80	RB1	18	9	27	1236.19
#81	TRPS1	18	10	28	1710.761
#82	IKZF1	18	7	25	205.412
#83	HOXA4	17	12	29	4501.251
#84	E2F8	17	8	25	2545.491
#85	SOX12	17	9	26	731.863
#86	VENTX	17	13	30	1694.198
#87	HMGA2	17	11	28	1276.635
#88	ZNF3	17	11	28	1476.862
#89	NKX2-8	17	9	26	1250.97
#90	KLF4	17	9	26	710.755
#91	GATA2	17	12	29	2459.157
#92	SNAI3	17	6	23	593.336
#93	IRX4	17	5	22	527.722
#94	KLF10	17	11	28	1186.82
#95	HOXB2	17	15	32	3048.912
#96	SNAI2	17	15	32	2671.521
#97	ERG	16	13	29	1318.626
#98	E2F1	16	3	19	169.692
#99	FOXN1	16	9	25	1715.525
#100	HOXA5	16	4	20	1396.609
#101	ZSCAN29	16	9	25	1292.285
#102	E2F5	16	9	25	3951.003
#103	TBX5	16	7	23	1154.38
#104	NR5A2	16	7	23	1195.422
#105	PRRX2	16	14	30	1205.625
#106	ZNF92	16	10	26	936.067
#107	HOXD9	16	10	26	1405.902
#108	MSRB2	16	8	24	2976.591
#109	LZTS1	16	7	23	1037.837
#110	POU5F1	16	11	27	2848.83
#111	HOXA7	16	10	26	2260.482
#112	LHX6	16	11	27	1801.104
#113	CREB3L3	16	7	23	929.221
#114	TWIST2	15	14	29	779.882
#115	HOXA3	15	6	21	1393.936
#116	ESR1	15	13	28	1047.987
#117	PAX6	15	9	24	1636.541
#118	PCGF6	15	10	25	1414.883
#119	HMGA1	15	10	25	1026.007
#120	ELF4	15	9	24	1340.165
#121	HOXC9	15	6	21	414.162
#122	ZNF643	15	9	24	1449.138
#123	CIR1	15	3	18	811.63
#124	MECOM	15	7	22	320.349
#125	ELF3	15	13	28	3091.159
#126	POU2F3	15	7	22	154.823
#127	MLXIPL	15	7	22	599.639
#128	GTF2H2	14	7	21	482.168
#129	ESRRB	14	18	32	3149.147
#130	ZNF219	14	12	26	2359.634
#131	MNX1	14	11	25	2167.884
#132	RCOR2	14	9	23	335.977
#133	TFAP2A	14	9	23	476.84
#134	ZSCAN2	14	9	23	1773.338
#135	ZNF397	14	6	20	1308.555
#136	BATF2	14	15	29	1382.057
#137	HMGB2	14	9	23	2168.367
#138	EN2	14	13	27	2371.259
#139	NR4A3	13	8	21	1663.309
#140	MYT1	13	13	26	2447.491
#141	FOXD4L1	13	8	21	805.011
#142	MEOX2	13	10	23	408.982
#143	MYT1L	13	4	17	343.443
#144	HOXB4	13	9	22	763.198
#145	SOX15	13	9	22	488.716
#146	HOXA6	13	3	16	114.38
#147	FOXI2	13	13	26	1795.54
#148	HES6	13	8	21	242.923
#149	SOX21	13	4	17	102.219
#150	HMX2	13	15	28	2601.726
#151	BACH2	13	10	23	1613.329
#152	TRERF1	13	8	21	952.43
#153	MEIS3	13	9	22	2750.03
#154	ZFP42	13	13	26	1472.906
#155	NFIX	13	13	26	3457.015
#156	IRF1	13	6	19	166.431
#157	SOX8	12	11	23	1792.083
#158	C2orf3	12	11	23	1165.853
#159	TBX1	12	11	23	826.748
#160	PBX1	12	9	21	627.401
#161	POU4F1	12	19	31	3526.502
#162	TFAP4	12	10	22	2386.157
#163	TCF19	12	12	24	960.094
#164	ZHX2	12	10	22	720.57
#165	ASCL2	12	16	28	1055.483
#166	CBFA2T2	12	11	23	1129.628
#167	SIM2	12	14	26	1761.606
#168	HSF1	12	13	25	1243.816
#169	GLI2	12	13	25	3169.755
#170	ELF5	12	6	18	123.945
#171	CTBP1	12	8	20	2373.234
#172	HOXB3	12	8	20	894.878
#173	SALL1	12	13	25	849.621
#174	FOXF2	12	14	26	3643.124
#175	HLF	12	14	26	1993.199
#176	FOXC2	12	11	23	2178.306
#177	STAT1	12	7	19	251.809
#178	ZSCAN18	12	10	22	336.466
#179	NRL	12	13	25	2944.986
#180	HOXD8	12	7	19	1279.252
#181	NPAS2	12	11	23	2550.688
#182	ZIC2	12	19	31	2923.346
#183	JUNB	11	14	25	3744.917
#184	MAF	11	15	26	1222.337
#185	ATF3	11	11	22	925.337
#186	RORC	11	11	22	1048.096
#187	POU3F1	11	13	24	3190.456
#188	SOX6	11	7	18	726.262
#189	TSC22D3	11	14	25	695.863
#190	FOXQ1	11	7	18	539.28
#191	VDR	11	11	22	1629.191
#192	TCF7L1	11	11	22	944.211
#193	HIC1	11	15	26	2278.997
#194	NOBOX	11	12	23	1509.043
#195	POU1F1	11	14	25	1500.911
#196	IRX3	11	9	20	1774.918
#197	MSL3	11	12	23	1262.658
#198	EOMES	11	6	17	370.391
#199	HOXB9	11	7	18	739.686
#200	NR1D1	11	14	25	1165.295
#201	PRRX1	11	5	16	704.981
#202	PHOX2A	11	11	22	1106.98
#203	WT1	11	14	25	1344.139
#204	OTX1	11	19	30	1595.641
#205	PKNOX2	11	17	28	1171.971
#206	ZNF445	11	12	23	1955.629
#207	SMAD9	11	16	27	1190.342
#208	SLC26A3	11	5	16	412.238
#209	ZFPM2	11	17	28	1196.982
#210	MSC	11	15	26	2565.584
#211	NFE2	11	21	32	2637.936
#212	HEYL	11	8	19	363.312
#213	FOXD1	10	12	22	5125.212
#214	SOX5	10	13	23	2796.419
#215	CSDA	10	7	17	648.594
#216	STAT4	10	9	19	364.361
#217	FOXA1	10	9	19	3933.716
#218	HOXD13	10	12	22	582.183
#219	ANKRD30A	10	12	22	1022.089
#220	TBX3	10	12	22	1374.658
#221	MKX	10	16	26	730.172
#222	FOXP4	10	12	22	1792.974
#223	SATB1	10	18	28	2429.861
#224	ATF7	10	12	22	673.47
#225	FOXN4	10	11	21	1207.195
#226	RHOXF2B	10	10	20	1002.218
#227	MSX1	10	14	24	1917.268
#228	OVOL1	10	9	19	415.957
#229	NKX2-5	10	13	23	1503.324
#230	RBPJ	10	10	20	1995.328
#231	TCF20	10	13	23	1820.084
#232	ETV3L	10	13	23	710.449
#233	HEY1	10	5	15	461.46
#234	ALS2CR8	9	17	26	1369.696
#235	HOXD4	9	12	21	449.195
#236	HR	9	13	22	1467.905
#237	SIM1	9	12	21	934.157
#238	TFCP2L1	9	17	26	1604.336
#239	FOXS1	9	7	16	253.371
#240	TFEB	9	17	26	2196.825
#241	BHLHE41	9	19	28	3760.857
#242	NR1D2	9	9	18	2853.433
#243	EGR1	9	7	16	846.468
#244	IRX5	9	13	22	1647.04
#245	RXRG	9	9	18	492.52
#246	ISL2	9	13	22	1339.846
#247	NKX6-1	9	10	19	1755.758
#248	SPIB	9	11	20	487.585
#249	RORA	9	12	21	1337.124
#250	ZNF155	9	10	19	2433.043
#251	TGIF1	9	5	14	547.993
#252	HOXC10	9	11	20	296.778
#253	RAX	9	13	22	2094.749
#254	ZNF71	9	8	17	1816.554
#255	FOXP2	9	11	20	799.475
#256	TGIF2LY	9	11	20	1079.354
#257	NFATC4	9	10	19	1101.941
#258	FOS	9	6	15	174.424
#259	CEBPD	9	9	18	508.928
#260	ZNF33A	9	9	18	781.882
#261	FOXR2	9	10	19	1904.387
#262	PITX1	9	15	24	2288.396
#263	SCRT1	9	10	19	608.413
#264	SIX6	9	3	12	424.953
#265	ETV1	9	13	22	479.93
#266	NKX2-6	9	10	19	1276.786
#267	LBX2	9	14	23	965.077
#268	CSRNP3	9	8	17	697.261
#269	FOXA3	9	13	22	1979.758
#270	RARA	9	11	20	912.967
#271	RUNX3	9	12	21	2215.244
#272	NFYA	9	6	15	281.017
#273	NR3C2	8	14	22	1488.912
#274	NR1H3	8	13	21	584.814
#275	AEBP1	8	11	19	958.48
#276	FOXJ1	8	17	25	1709.314
#277	HOXA9	8	12	20	632.5
#278	KCNH8	8	15	23	733.427
#279	GSC	8	9	17	786.127
#280	SMAD6	8	14	22	978.055
#281	FOSB	8	8	16	1524.721
#282	TCF12	8	16	24	1658.773
#283	TLX2	8	11	19	949.37
#284	HOXA1	8	11	19	1160.664
#285	CDKN2A	8	12	20	1020.197
#286	HOXD11	8	10	18	2053.055
#287	FOXB2	8	9	17	1795.267
#288	ZIM2	8	10	18	1820.28
#289	FOXE3	8	12	20	1739.463
#290	SOX11	8	17	25	1390.097
#291	ZNF81	8	16	24	1579.417
#292	TFAP2C	8	17	25	2930.039
#293	ARGFX	8	16	24	1998.766
#294	PAX5	8	9	17	1010.581
#295	PAX7	8	11	19	1389.09
#296	TCF7	8	12	20	747.675
#297	HOXD10	8	10	18	1771.213
#298	HOXC11	8	13	21	1869.034
#299	NR4A2	8	13	21	1774.077
#300	ASCL1	8	19	27	2439.471
#301	KLF15	8	16	24	1006.969
#302	FOXD2	8	7	15	1878.14
#303	SEBOX	8	12	20	1227.329
#304	PPARG	8	10	18	793.529
#305	PRDM1	8	14	22	445.443
#306	BNC1	8	8	16	154.731
#307	PBX4	8	17	25	1350.456
#308	ZNF69	8	6	14	837.263
#309	DPRX	8	7	15	719.835
#310	MAX	8	5	13	470.527
#311	ELK4	8	12	20	955.303
#312	IRF6	8	11	19	843.101
#313	ESX1	8	10	18	1753.077
#314	PAX4	8	11	19	597.426
#315	SMAD1	7	10	17	1076.636
#316	FOXA2	7	9	16	1022.039
#317	SOX9	7	15	22	1256.668
#318	MESP1	7	7	14	1096.07
#319	LHX3	7	11	18	723.365
#320	FOXE1	7	14	21	1166.586
#321	NKX2-3	7	11	18	1113.663
#322	PITX2	7	8	15	764.171
#323	HES5	7	9	16	320.411
#324	ZNF85	7	8	15	967.412
#325	FOXN3	7	10	17	1134.143
#326	SIX1	7	15	22	1338.496
#327	MYOD1	7	16	23	1497.728
#328	GLI3	7	15	22	2278.965
#329	FOXL2	7	6	13	632.157
#330	ZNF167	7	14	21	1139.747
#331	HOXA13	7	11	18	1685.13
#332	SCML1	7	10	17	685.596
#333	HHEX	7	10	17	997.131
#334	ZEB1	7	14	21	969.969
#335	FOXD4	7	11	18	916.757
#336	SIX2	7	12	19	1227.292
#337	CUX2	7	14	21	330.889
#338	FOXP1	7	16	23	787.238
#339	FOXC1	7	18	25	1340.455
#340	TCF21	7	8	15	1115.901
#341	TFAP2B	7	13	20	1055.677
#342	ZNF323	7	14	21	1741.66
#343	ZFHX4	7	14	21	1982.204
#344	GBX2	7	14	21	746.153
#345	PITX3	7	11	18	3569.653
#346	ZXDA	7	9	16	641.913
#347	POU2F2	7	8	15	323.238
#348	NPAS1	7	16	23	2198.701
#349	KLF12	7	13	20	1011.578
#350	TBX2	7	16	23	1009.492
#351	E2F2	7	11	18	669.294
#352	FOXI1	7	9	16	1046.975
#353	HOXC8	6	12	18	335.523
#354	ISL1	6	22	28	2153.262
#355	POU3F2	6	8	14	211.602
#356	RORB	6	12	18	633.948
#357	HIF3A	6	17	23	1648.426
#358	PROX1	6	16	22	2876.547
#359	LHX1	6	14	20	1464.017
#360	IRX6	6	19	25	697.951
#361	SIX4	6	13	19	1223.196
#362	NR0B1	6	19	25	1544.273
#363	NME2	6	17	23	1559.13
#364	RUNX1	6	12	18	1405.698
#365	BRD8	6	15	21	614.107
#366	LHX9	6	14	20	960.432
#367	MAFF	6	15	21	656.992
#368	GAS7	6	15	21	874.864
#369	FOXR1	6	16	22	1513.312
#370	PTH	6	9	15	687.276
#371	POU4F2	6	9	15	574.633
#372	TEAD1	6	13	19	828.675
#373	HOXD1	6	16	22	1378.13
#374	TFAP2D	6	12	18	992.98
#375	NKX2-4	6	14	20	1382.996
#376	NR2F1	6	13	19	1057.104
#377	GTF2I	6	11	17	726.785
#378	MEIS2	6	14	20	742.137
#379	ZNF449	6	9	15	2160.434
#380	TAF13	6	8	14	1330.137
#381	NR2E3	6	8	14	591.6
#382	POU3F3	6	9	15	1313.878
#383	USF2	6	12	18	1032.041
#384	ZSCAN20	6	8	14	506.803
#385	MAFG	6	10	16	673.154
#386	NFE2L3	6	15	21	1269.736
#387	PPARA	6	13	19	955.03
#388	RARB	5	12	17	1174.287
#389	NFATC1	5	11	16	826.095
#390	NKX3-1	5	13	18	651.002
#391	ZSCAN5D	5	10	15	586.183
#392	ZIC3	5	20	25	1122.03
#393	DMBX1	5	8	13	744.004
#394	NEUROG1	5	16	21	696.338
#395	RHOXF1	5	14	19	820.348
#396	PRDM2	5	16	21	2771.511
#397	GSC2	5	10	15	1347.836
#398	HOXC5	5	14	19	1071.704
#399	ZNF215	5	15	20	1210.472
#400	WNT5A	5	18	23	883.782
#401	HOXA11	5	15	20	1452.341
#402	MAFA	5	14	19	955.523
#403	CREB3L1	5	13	18	821.179
#404	GATA4	5	11	16	446.195
#405	TLX1	5	11	16	850.58
#406	TWIST1	5	14	19	573.602
#407	HOXA10	5	9	14	364.095
#408	NKX3-2	5	17	22	2041.053
#409	EGR2	5	10	15	639.807
#410	THRA	5	11	16	215.748
#411	TCEAL1	5	12	17	473.304
#412	TPRX1	5	11	16	911.825
#413	MZF1	5	17	22	1815.613
#414	CITED1	5	14	19	330.336
#415	RUNX2	5	12	17	1690.782
#416	HOXB13	5	14	19	279.24
#417	GATA5	5	15	20	1333.793
#418	HAND1	5	11	16	969.417
#419	ZNF80	4	11	15	930.019
#420	TEAD4	4	8	12	292.892
#421	ZNF197	4	13	17	392.643
#422	RARG	4	14	18	328.709
#423	ZSCAN5B	4	13	17	418.558
#424	HAND2	4	8	12	260.936
#425	MMP14	4	14	18	360.226
#426	FOXK2	4	11	15	707.523
#427	TLX3	4	10	14	370.374
#428	EGR3	4	10	14	1192.96
#429	LMX1B	4	9	13	283.058
#430	VSX2	4	7	11	354.34
#431	GLIS2	4	16	20	1078.131
#432	NFATC2	4	14	18	1044.375
#433	NR4A1	4	9	13	920.785
#434	VSX1	4	15	19	1027.809
#435	MIXL1	4	6	10	457.975
#436	FOXB1	4	12	16	514.126
#437	GSX2	4	14	18	503.919
#438	CUX1	4	16	20	451.602
#439	GCM1	4	15	19	1032.935
#440	DLX2	4	13	17	376.371
#441	CREB5	4	15	19	473.949
#442	FEV	4	15	19	609.282
#443	FBXW7	4	13	17	1603.603
#444	RFX3	4	13	17	248.338
#445	ZNF169	4	9	13	610.888
#446	TMEM229A	4	16	20	517.08
#447	FOXF1	4	11	15	493.85
#448	PAX8	4	16	20	962.507
#449	ONECUT2	4	17	21	686.344
#450	ZSCAN4	4	17	21	273.304
#451	PHOX2B	4	15	19	1056.367
#452	VTN	4	15	19	1264.365
#453	TFAP2E	3	16	19	2414.925
#454	SP3	3	8	11	939.877
#455	CTNNB1	3	15	18	424.244
#456	TCF15	3	17	20	331.112
#457	EGR4	3	11	14	1189.13
#458	RCAN1	3	15	18	1273.328
#459	HEY2	3	13	16	454.278
#460	ZNF238	3	11	14	538.489
#461	LHX2	3	15	18	219.598
#462	NKX6-2	3	12	15	490.395
#463	SREBF1	3	14	17	869.427
#464	ZNF70	3	10	13	537.059
#465	TFEC	3	11	14	264.215
#466	NR1I3	3	8	11	128.679
#467	NR1I2	3	19	22	546.904
#468	ZHX1	3	12	15	3816.051
#469	BSX	3	16	19	609.187
#470	ZIC1	3	10	13	478.07
#471	TFDP3	3	13	16	1217.957
#472	L3MBTL4	3	14	17	1031.758
#473	FOXD4L4	3	8	11	1155.383
#474	MYOG	3	10	13	230.739
#475	MYCN	3	11	14	1804.227
#476	HMX3	2	12	14	654.682
#477	TSC22D1	2	14	16	368.332
#478	HNF4A	2	16	18	773.961
#479	ZNF117	2	10	12	205.287
#480	ZNF268	2	10	12	501.404
#481	ESRRG	2	24	26	327.344
#482	DMRT2	2	17	19	495.236
#483	SHOX	2	11	13	814.356
#484	ZNF165	2	17	19	610.169
#485	PGR	2	15	17	200.529
#486	GLIS3	2	15	17	643.606
#487	ARNTL	2	15	17	843.813
#488	IRF5	2	13	15	383.702
#489	ZNF19	2	13	15	180.352
#490	OLIG2	1	19	20	923.104
#491	DLX4	1	8	9	65.66
#492	GATA1	1	17	18	289.94
#493	LHX8	1	15	16	154.212
#494	BACH1	1	11	12	180.654
#495	ZNF483	1	9	10	49.15
#496	ZNF287	1	16	17	836.169
#497	TBX6	1	14	15	508.541
#498	RCOR1	1	15	16	144.517
#499	SOX1	0	10	10	0
#500	SRY	0	11	11	0