Hub Rank	Node	Children	Parents	Degree	Betweenness
#1	GATA3	75	5	80	98.042
#2	SPDEF	71	2	73	1583.774
#3	XBP1	66	4	70	2299.289
#4	FOXA1	65	1	66	91.5
#5	ESR1	56	8	64	380.68
#6	TBX19	53	3	56	93.152
#7	TAF4B	51	9	60	1511.642
#8	RUNX1T1	50	5	55	10741.259
#9	FOXC1	50	3	53	590.206
#10	CNOT8	48	5	53	1457.556
#11	ELK3	47	2	49	234.818
#12	EN1	47	8	55	162.442
#13	MYBL2	45	5	50	510.136
#14	FOXM1	45	3	48	1234.339
#15	HDAC2	44	5	49	1684.899
#16	EBF1	43	5	48	699.979
#17	NFIL3	43	12	55	4648.09
#18	TAF5	41	4	45	378.647
#19	SMAD4	41	2	43	158.012
#20	FLI1	41	1	42	39.964
#21	TSHZ2	41	6	47	683.787
#22	YBX1	40	4	44	2858.208
#23	ZNF148	40	4	44	100.996
#24	ZBTB38	40	3	43	2253.042
#25	ATF1	39	3	42	289.465
#26	NFXL1	39	7	46	1369.337
#27	LASS6	38	10	48	722.328
#28	HCLS1	38	1	39	502.09
#29	MZF1	38	4	42	606.06
#30	TCF7L1	38	7	45	1074.6
#31	SOX10	38	3	41	21.185
#32	SOX15	37	3	40	1818.886
#33	IKZF1	36	2	38	1188.719
#34	SP1	36	2	38	61.868
#35	AR	36	8	44	1935.101
#36	TCF25	36	4	40	3814.534
#37	ZFPM1	35	6	41	869.69
#38	TCF15	35	4	39	849.275
#39	SNAI2	34	13	47	4961.314
#40	CREBL2	34	11	45	1372.311
#41	ZFP36L2	33	7	40	1962.809
#42	ENO1	33	7	40	1909.758
#43	FOXO1	33	6	39	1704.001
#44	E2F3	32	12	44	1401.259
#45	FOXN2	32	10	42	891.883
#46	NFYC	32	4	36	456.901
#47	PGR	31	11	42	3247.252
#48	SP3	31	3	34	151.665
#49	HIC1	31	4	35	196.81
#50	TFAM	30	9	39	2364.423
#51	TSHZ3	30	5	35	427.248
#52	PTTG1	30	7	37	1038.008
#53	ZFP36L1	30	9	39	1355.189
#54	VAV1	29	2	31	3064.513
#55	MEF2C	29	9	38	2931.237
#56	ETS1	29	7	36	2462.704
#57	RBPJ	28	6	34	3733.768
#58	TCF7L2	28	10	38	1809.938
#59	E2F2	28	10	38	4299.794
#60	KLF11	28	19	47	3173.551
#61	TSC22D4	28	4	32	526.918
#62	BACH1	28	14	42	4033.01
#63	MEIS3P1	28	14	42	6324.084
#64	L3MBTL4	27	9	36	1298.833
#65	ZFPM2	27	3	30	338.675
#66	PURA	27	8	35	1395.712
#67	SOX8	27	13	40	961.489
#68	TRIM29	27	9	36	142.452
#69	TCF12	26	3	29	260.565
#70	CREBZF	26	8	34	2855.256
#71	KLF3	26	9	35	1377.92
#72	RUNX2	26	4	30	196.486
#73	PRDM1	26	9	35	9490.036
#74	SP140	25	3	28	29.488
#75	TRIM22	25	8	33	972.555
#76	STAT3	25	7	32	690.561
#77	ELF1	25	8	33	252.479
#78	CREB3L4	25	11	36	2011.645
#79	ETV1	25	9	34	254.244
#80	IRF8	25	5	30	181.451
#81	SPEN	24	1	25	3.699
#82	ERG	24	9	33	247.865
#83	RUNX3	24	10	34	3709.084
#84	HOXA3	24	9	33	1557.255
#85	MLL	24	5	29	230.673
#86	ZNF367	24	7	31	1779.036
#87	ADNP	24	8	32	356.381
#88	RXRB	23	5	28	101.982
#89	SIX5	23	15	38	2675.181
#90	GAS7	23	8	31	1755.064
#91	GATAD1	23	11	34	2169.067
#92	E2F8	23	6	29	642.51
#93	MAX	23	3	26	522.06
#94	GTF2I	22	6	28	118.177
#95	C5orf41	22	17	39	2498.205
#96	ARID4A	22	11	33	1011.213
#97	HOXA9	22	9	31	3766.66
#98	GLI3	22	11	33	505.245
#99	NOLC1	22	9	31	2355.152
#100	CSDA	22	20	42	2374.565
#101	ZEB2	21	7	28	1095.965
#102	CEBPB	21	14	35	4384.714
#103	RELB	21	10	31	976.583
#104	ZEB1	21	8	29	1309.823
#105	AEBP1	21	7	28	440.081
#106	MSX2	21	13	34	533.487
#107	LMO4	21	12	33	376.418
#108	MGA	21	3	24	597.024
#109	MAFB	21	8	29	1165.406
#110	BLZF1	21	10	31	529.93
#111	TCF4	20	11	31	3352.002
#112	KLF5	20	19	39	1156.308
#113	UBN1	20	5	25	91.581
#114	FOXP2	20	14	34	12858.886
#115	PURB	20	10	30	2652.062
#116	YEATS4	20	14	34	6884.231
#117	SOX6	20	11	31	1011.992
#118	BACH2	20	13	33	1431.892
#119	TCEAL1	20	19	39	1968.757
#120	CBFA2T2	20	10	30	754.425
#121	NFYB	19	11	30	2084.818
#122	NFIA	19	17	36	1596.787
#123	TAF12	19	5	24	1579.8
#124	FOXK2	19	12	31	3256.44
#125	BRD8	19	13	32	1674.68
#126	HR	19	14	33	549.927
#127	SPI1	19	11	30	6078.825
#128	CBFB	19	15	34	1666.567
#129	HMGB1	19	10	29	1205.147
#130	CREB1	19	4	23	108.171
#131	PBX1	19	13	32	482.576
#132	MEOX2	19	7	26	327.039
#133	ELF5	18	12	30	1142.497
#134	PPARA	18	12	30	431.386
#135	ZNF207	18	7	25	2306.089
#136	TCF19	18	10	28	1526.1
#137	NFIC	18	10	28	637.742
#138	ZHX1	18	13	31	1624.127
#139	NOTCH1	18	12	30	962.868
#140	NFE2L2	18	13	31	3735.218
#141	CNOT7	17	9	26	642.495
#142	IRX1	17	13	30	911.421
#143	NR2F1	17	14	31	597.698
#144	SPIB	17	14	31	1760.351
#145	BHLHE40	17	11	28	3417.434
#146	HHEX	17	14	31	1937.433
#147	ZFHX4	17	10	27	1423.726
#148	TWIST2	17	12	29	876.826
#149	NFATC3	17	2	19	1046.463
#150	ZHX2	17	12	29	1729.288
#151	NFATC4	17	18	35	1651.103
#152	KLF12	17	13	30	1822.437
#153	CREM	17	21	38	854.836
#154	NR3C1	17	9	26	871.171
#155	ETS2	17	11	28	1299.435
#156	ATF2	17	7	24	145.131
#157	FOXP1	16	15	31	1418.076
#158	KLF9	16	14	30	1568.438
#159	SALL2	16	9	25	168.694
#160	GLI2	16	16	32	1390.43
#161	GABPB1	16	16	32	862.344
#162	TBX3	16	13	29	6783.432
#163	RARA	16	18	34	2677.7
#164	FOXN3	16	19	35	4814.073
#165	BHLHE41	16	11	27	458.604
#166	FOS	16	5	21	587.475
#167	RB1	16	9	25	182.528
#168	SOX4	15	19	34	3599.843
#169	ZNF397	15	17	32	771.47
#170	MECOM	15	11	26	5415.165
#171	JUND	15	12	27	4802.428
#172	ZNF639	15	14	29	1786.918
#173	MEOX1	15	13	28	1340.11
#174	NFAT5	15	5	20	556.557
#175	TEAD4	15	12	27	2236.99
#176	HSF1	15	8	23	1490.65
#177	PLSCR1	15	11	26	1294.784
#178	MITF	15	11	26	3215.433
#179	HMGA1	15	20	35	3792.606
#180	NFE2L3	15	13	28	2011.966
#181	RCOR1	15	15	30	662.335
#182	ANKRD30A	15	18	33	1189.616
#183	FBXW7	15	13	28	801.985
#184	IRF4	15	6	21	3522.624
#185	UHRF1	15	9	24	432.511
#186	FUBP1	14	12	26	931.882
#187	ZNF138	14	14	28	1071.416
#188	IRX5	14	18	32	524.159
#189	SMAD5	14	9	23	4792.572
#190	HOXC10	14	19	33	1371.479
#191	IRF6	14	14	28	1496.033
#192	SMAD9	14	12	26	979.022
#193	NR2E3	14	11	25	5050.823
#194	BCL3	14	8	22	427.943
#195	DLX6	14	10	24	143.846
#196	ZNF131	14	11	25	600.579
#197	MEIS2	14	15	29	681.232
#198	KDM5A	14	12	26	4805.394
#199	ARNTL2	14	11	25	285.804
#200	EOMES	14	6	20	25.651
#201	NANOG	13	10	23	1369.816
#202	STAT2	13	7	20	2035.506
#203	NPAT	13	15	28	437.716
#204	FOSL2	13	18	31	4095.62
#205	HMG20B	13	15	28	874.831
#206	TBX2	13	12	25	555.199
#207	TWIST1	13	17	30	4355.926
#208	FOSL1	13	20	33	11671.452
#209	FOSB	13	7	20	427.594
#210	BATF2	13	15	28	15219.905
#211	HOXA5	13	9	22	6165.2
#212	KLF10	13	14	27	630.705
#213	CSRNP3	13	17	30	1238.237
#214	CTNNB1	13	14	27	1656.86
#215	NFX1	13	7	20	972.088
#216	FOXO3	13	14	27	2195.886
#217	SLC2A4RG	13	19	32	5722.091
#218	ZFHX3	13	15	28	4596.235
#219	MEIS3	13	13	26	2687.808
#220	RORA	12	16	28	1504.07
#221	CITED2	12	15	27	1859.38
#222	SOX13	12	14	26	1214.212
#223	E2F7	12	9	21	213.955
#224	RERE	12	14	26	1089.819
#225	PITX2	12	16	28	7240.429
#226	ATF3	12	6	18	422.571
#227	TAF7	12	13	25	1466.806
#228	MEF2A	12	11	23	415.58
#229	ZNF92	12	11	23	1398.508
#230	BTG2	12	14	26	1177.358
#231	HEY1	12	20	32	5273.18
#232	POU2F2	12	13	25	786.721
#233	ZSCAN18	12	20	32	4475.845
#234	PRRX1	12	12	24	2111.499
#235	STAT1	12	5	17	383.78
#236	EGR1	12	16	28	1192.305
#237	KLF2	12	13	25	1929.609
#238	ZNF274	12	12	24	1114.113
#239	TFEC	12	13	25	711.241
#240	SOX7	12	15	27	1007.372
#241	GTF2H3	11	4	15	1118.405
#242	STAT5B	11	12	23	835.597
#243	RCAN1	11	12	23	394.803
#244	ALS2CR8	11	11	22	1637.938
#245	TGIF2	11	18	29	842.027
#246	LCOR	11	16	27	729.107
#247	SMAD2	11	13	24	747.505
#248	CDKN2A	11	22	33	1337.713
#249	JUN	11	14	25	1829.218
#250	IRF1	11	10	21	14546.824
#251	NFIX	11	14	25	1394.067
#252	ARNT	11	6	17	179.631
#253	RFXAP	11	13	24	443.455
#254	FOXP4	11	17	28	2425.36
#255	MYC	11	19	30	3248.239
#256	HIF1A	11	14	25	379.749
#257	THRB	11	18	29	6834.278
#258	DBP	11	18	29	964.446
#259	HMGB2	11	11	22	491.212
#260	TRPS1	11	22	33	477.233
#261	GTF2H2	11	14	25	1651.212
#262	NFKB2	11	13	24	2261.425
#263	NFATC2	11	9	20	412.079
#264	ZSCAN16	10	16	26	999.938
#265	ONECUT2	10	24	34	2522.319
#266	FOXO6	10	17	27	1188.045
#267	CREB5	10	18	28	613.352
#268	SLC30A9	10	18	28	1769.602
#269	ETV5	10	20	30	1980.555
#270	ZNF93	10	21	31	1021.809
#271	NFYA	10	18	28	450.429
#272	HSF2	10	11	21	610.43
#273	HOXC9	10	16	26	1519.568
#274	TCF3	10	13	23	200.527
#275	TP63	10	14	24	1569.478
#276	PRDM2	10	13	23	1444.18
#277	ZXDC	10	16	26	1763.907
#278	JUNB	10	7	17	1835.883
#279	STAT4	10	11	21	766.642
#280	FOXC2	10	21	31	1205.121
#281	GATA2	10	17	27	776.744
#282	ZNF135	10	19	29	4169.306
#283	ZNF117	10	14	24	2747.069
#284	GLIS2	10	10	20	120.917
#285	NFIB	10	22	32	1134.023
#286	AHR	10	15	25	1363.343
#287	TBX5	10	14	24	320.702
#288	TP53	10	15	25	1756.307
#289	SMAD3	9	22	31	791.443
#290	GCFC1	9	13	22	1377.418
#291	HOXB13	9	27	36	2374.673
#292	MAF	9	14	23	536.454
#293	NR2C1	9	22	31	1147.994
#294	ZNF217	9	16	25	911.79
#295	MSX1	9	17	26	2951.972
#296	HOXB6	9	10	19	1806.195
#297	REL	9	18	27	1384.948
#298	SOX11	9	18	27	289.734
#299	KLF6	9	13	22	1039.258
#300	TEAD2	9	10	19	375.97
#301	HOXA7	9	12	21	467.335
#302	ZKSCAN1	9	14	23	4863.135
#303	NR2F2	9	22	31	485.788
#304	TSHZ1	9	22	31	2435.461
#305	ZNF167	9	18	27	1097.05
#306	FOXF2	9	16	25	1839.88
#307	CREB3L2	9	25	34	6959.51
#308	ZNF281	9	17	26	1639.69
#309	ATF6	9	15	24	4447.024
#310	SMAD1	9	20	29	1323.098
#311	HOXC11	9	12	21	408.007
#312	MYT1	9	21	30	4431.229
#313	HOXB3	8	16	24	748.197
#314	HOXC4	8	15	23	731.122
#315	BCL6	8	18	26	728.317
#316	SOX9	8	18	26	760.204
#317	TRERF1	8	16	24	729.619
#318	ZNF83	8	20	28	644.894
#319	AFF4	8	7	15	379.246
#320	ZNF91	8	19	27	868.244
#321	ZNF140	8	11	19	959.833
#322	MTA1	8	16	24	725.303
#323	TGIF1	8	15	23	1754.006
#324	NR1H3	8	16	24	543.476
#325	CREB3L1	8	15	23	1284.12
#326	MLLT10	8	7	15	395.087
#327	LZTS1	8	20	28	4365.132
#328	TFCP2	8	13	21	827.531
#329	ZNF277	8	14	22	3786.589
#330	SATB1	8	23	31	640.37
#331	HOXD1	8	15	23	2565.878
#332	SCAND1	8	23	31	3858.651
#333	SIX3	8	14	22	739.571
#334	HOXC13	7	18	25	2309.773
#335	MYCN	7	22	29	1839.247
#336	MMP14	7	18	25	1902.774
#337	NR1D2	7	12	19	1150.875
#338	SREBF1	7	16	23	1396.628
#339	MEIS1	7	15	22	388.941
#340	SIX4	7	26	33	1990.782
#341	MAFF	7	15	22	2689.824
#342	MNX1	7	13	20	722.068
#343	TFAP2A	7	21	28	2695.938
#344	SOX2	7	21	28	3529.443
#345	HOXD3	7	16	23	1982.076
#346	HOXD4	7	13	20	510.258
#347	TSC22D3	7	14	21	672.9
#348	SP4	7	13	20	1997.421
#349	TBX10	7	17	24	753.549
#350	IRF2	7	18	25	4033.084
#351	HIF3A	7	14	21	1486.544
#352	MTA2	7	13	20	3694.377
#353	PAX6	6	14	20	332.627
#354	GRHL2	6	16	22	3313.937
#355	EGR2	6	13	19	503.562
#356	POU2F3	6	19	25	3399.15
#357	ZNF165	6	20	26	352.34
#358	ZNF238	6	22	28	407.215
#359	GATA5	6	23	29	2063.962
#360	MSRB2	6	19	25	263.666
#361	HOXD8	6	18	24	3094.818
#362	SOX18	6	18	24	385.643
#363	IRF9	6	10	16	683.504
#364	SLC26A3	6	19	25	1548.51
#365	CBFA2T3	6	27	33	1352.047
#366	ZNF500	6	19	25	402.888
#367	CBL	6	10	16	640.192
#368	EPAS1	6	13	19	1755.204
#369	FOXQ1	6	21	27	943.502
#370	HOXB7	6	16	22	1766.071
#371	MSL3	6	17	23	1025.06
#372	TULP4	6	15	21	922.68
#373	C11orf9	6	18	24	1663.892
#374	ARX	6	25	31	1163.256
#375	NR3C2	6	15	21	263.037
#376	HES6	6	22	28	1428.824
#377	TFCP2L1	6	19	25	384.669
#378	TCF7	6	13	19	172.908
#379	ZNF232	6	24	30	952.37
#380	ZNF24	6	20	26	463.358
#381	KDM5B	6	28	34	2518.601
#382	TEF	6	16	22	599.861
#383	EGR3	5	14	19	769.632
#384	SIX2	5	32	37	984.38
#385	DLX4	5	20	25	215.329
#386	PPARG	5	12	17	1957.835
#387	TARDBP	5	21	26	3088.273
#388	WNT5A	5	21	26	232.733
#389	SOX12	5	19	24	3967.452
#390	LHX6	5	22	27	649.06
#391	VAX2	5	21	26	2117.017
#392	IRX3	5	15	20	2677.22
#393	GLIS3	5	9	14	963.388
#394	SOLH	5	11	16	984.918
#395	HOXA10	5	18	23	6806.433
#396	LHX2	5	22	27	2036.067
#397	KLF7	5	18	23	244.668
#398	FOXD1	5	23	28	1092.044
#399	TCFL5	5	16	21	598.906
#400	MESP1	5	29	34	2273.122
#401	PBX4	5	18	23	527.401
#402	SATB2	5	23	28	3060.432
#403	HEYL	5	15	20	496.221
#404	IRX2	5	26	31	2529.457
#405	LASS2	5	14	19	780.021
#406	SIX1	5	21	26	1292.902
#407	ASCL1	5	24	29	476.547
#408	SUPT4H1	5	22	27	271.275
#409	ASCL2	5	27	32	4152.565
#410	C1orf85	5	19	24	1121.496
#411	PHTF1	5	16	21	379.079
#412	FOXA3	5	16	21	1292.683
#413	ZIC1	5	19	24	53.964
#414	HOXB5	5	13	18	1258.074
#415	HOXB2	5	14	19	831.142
#416	RARB	4	23	27	535.35
#417	TAF1B	4	15	19	2662.038
#418	ZNF85	4	21	25	560.689
#419	IRX4	4	21	25	4004.615
#420	EHF	4	24	28	427.877
#421	ELF3	4	27	31	2015.576
#422	TSC22D1	4	28	32	4075.782
#423	E2F5	4	14	18	543.738
#424	NR4A1	4	9	13	257.67
#425	RUNX1	4	27	31	339.343
#426	ISL1	4	12	16	343.863
#427	ESRRG	4	24	28	1991.744
#428	ZIC2	4	25	29	2146.607
#429	ARNTL	4	17	21	362.764
#430	TFAP2B	4	29	33	4364.079
#431	BCL11B	4	11	15	248.102
#432	PROX1	4	24	28	2570.424
#433	HOXD10	4	23	27	425.043
#434	ATF7	4	19	23	486.494
#435	PEG3	4	30	34	9686.362
#436	HOXA2	4	17	21	466.847
#437	GATAD2B	4	23	27	1220.247
#438	RORB	4	20	24	688.132
#439	SCML1	4	13	17	570.426
#440	TFAP2C	4	18	22	627.494
#441	HLF	4	18	22	828.224
#442	ARNT2	3	19	22	118.743
#443	IRF7	3	14	17	231.537
#444	PBX3	3	26	29	786.474
#445	PGBD1	3	24	27	2295.284
#446	DLX1	3	22	25	347.416
#447	TAF5L	3	16	19	179.674
#448	ZNF33B	3	18	21	311.022
#449	FOXG1	3	22	25	1047.707
#450	ZNF268	3	16	19	201.998
#451	STRN3	3	21	24	675.785
#452	SMAD6	3	21	24	917.595
#453	GATA6	3	26	29	379.326
#454	NPAS2	3	22	25	130.034
#455	NR4A2	3	21	24	264.92
#456	OVOL1	3	21	24	831.75
#457	ZNF70	3	21	24	644.671
#458	ETV4	3	21	24	2964.56
#459	HES1	3	25	28	294.178
#460	NFATC1	3	17	20	492.774
#461	ETV6	3	19	22	380.09
#462	FOXI1	3	26	29	460.309
#463	CEBPA	3	20	23	366.958
#464	SIM2	3	20	23	459.703
#465	WT1	3	26	29	1738.401
#466	CITED1	2	22	24	119.134
#467	PITX1	2	29	31	233.629
#468	TFDP2	2	15	17	1310.571
#469	MXD1	2	20	22	68.058
#470	HEY2	2	24	26	2557.522
#471	MYCL1	2	19	21	159.362
#472	PAX7	2	20	22	781.967
#473	KLF4	2	17	19	692.552
#474	CTBP1	2	22	24	289.651
#475	NANOGNB	2	13	15	129.696
#476	SIN3A	2	24	26	114.525
#477	NR0B1	2	11	13	314.501
#478	HMGA2	2	18	20	895.666
#479	CEBPD	2	21	23	521.45
#480	ZNF256	2	25	27	1810.254
#481	TFEB	2	18	20	77.284
#482	GRHL3	2	22	24	167.541
#483	DLX2	1	19	20	87.661
#484	VDR	1	32	33	51.613
#485	ATF5	1	16	17	915.237
#486	PCGF2	1	21	22	183.139
#487	LHX8	1	12	13	55.534
#488	HOPX	1	28	29	152.284
#489	TFDP1	1	20	21	43.419
#490	LEF1	1	16	17	85.328
#491	MKX	1	26	27	1260.43
#492	HMBOX1	1	21	22	381.813
#493	RORC	1	20	21	13.855
#494	ZNF323	0	29	29	0
#495	HOXB8	0	18	18	0
#496	IRF5	0	24	24	0
#497	NKX3-1	0	35	35	0
#498	TBX1	0	25	25	0
#499	CUX2	0	22	22	0
#500	CCRN4L	0	26	26	0