Hub Rank	Node	Children	Parents	Degree	Betweenness
#1	NFYB	74	8	82	1422.31
#2	ASCL2	73	10	83	2417.861
#3	NFXL1	70	9	79	2357.925
#4	NR2C1	69	8	77	860.973
#5	ZNF131	65	5	70	152.448
#6	C2orf3	64	6	70	1101.148
#7	NFE2L1	61	9	70	795.075
#8	USF2	60	4	64	3271.198
#9	KLF4	59	9	68	1199.972
#10	ZNF148	59	8	67	837.931
#11	VDR	58	10	68	2360.618
#12	STAT1	56	1	57	19.869
#13	KLF9	55	13	68	3036.403
#14	NFE2L3	54	9	63	796.972
#15	PURA	53	11	64	5035.957
#16	TAF6	52	5	57	215.966
#17	RELB	50	11	61	5491.89
#18	YEATS4	49	5	54	119.92
#19	NR3C2	48	4	52	398.562
#20	RAX	47	5	52	451.419
#21	ZNF92	47	3	50	45.954
#22	ZNF19	47	4	51	304.015
#23	MYC	47	10	57	495.953
#24	SPIB	45	11	56	2709.362
#25	E2F6	44	7	51	257.34
#26	CITED2	44	11	55	1765.126
#27	TRPS1	44	12	56	5649.427
#28	MEF2D	43	9	52	850.734
#29	CUX1	41	6	47	1212.753
#30	MSL3	39	9	48	346.405
#31	HSF2	38	16	54	1442.256
#32	ARNTL2	38	14	52	1609.78
#33	PHOX2B	38	7	45	2505.772
#34	FUBP1	38	9	47	458.293
#35	TCEAL1	38	7	45	1891.823
#36	ZNF117	38	17	55	954.671
#37	SCML1	37	14	51	2216.667
#38	TGIF2	37	7	44	155.048
#39	ZNF367	37	9	46	233.468
#40	CBFB	37	14	51	1812.85
#41	ETV1	37	16	53	17100.795
#42	E2F3	37	8	45	371.9
#43	NFKB2	36	10	46	609.04
#44	ZNF236	35	8	43	259.945
#45	RXRA	35	8	43	6722.511
#46	CREBZF	35	11	46	331.744
#47	RFXAP	34	18	52	910.57
#48	ZEB1	34	3	37	230.947
#49	MEIS1	33	8	41	709.559
#50	GCFC1	33	13	46	533.402
#51	NR2F6	33	9	42	4845.386
#52	IRF6	33	13	46	667.07
#53	PLAGL2	32	8	40	964.463
#54	TFCP2L1	31	16	47	2197.949
#55	HMGA1	31	9	40	1784.446
#56	HAND1	31	9	40	852.44
#57	MITF	31	4	35	2516.459
#58	UHRF1	31	13	44	1256.779
#59	TAF1B	30	8	38	1563.943
#60	E2F2	29	15	44	4272.827
#61	FOXP1	29	9	38	279.264
#62	TEAD1	29	17	46	10654.305
#63	HNF4A	29	11	40	2454.642
#64	FOXN4	29	1	30	521.65
#65	GLIS2	29	9	38	1305.229
#66	GABPB1	28	7	35	169.967
#67	EPAS1	28	14	42	442.97
#68	LEF1	28	18	46	1607.792
#69	MXD1	27	13	40	1306.229
#70	SIX4	27	4	31	74.227
#71	TRERF1	27	11	38	1625.165
#72	PPARD	27	7	34	130.484
#73	NOLC1	27	12	39	490.062
#74	TCFL5	26	17	43	720.861
#75	TEF	26	15	41	1016.455
#76	TEAD4	26	10	36	967.233
#77	FOXQ1	26	19	45	7073.904
#78	MYNN	26	10	36	10203.95
#79	TFDP1	25	12	37	389.802
#80	NFIC	25	15	40	1201.615
#81	KLF6	25	12	37	564.489
#82	PTTG1	25	11	36	1257.87
#83	SOX4	25	11	36	513.76
#84	CDX2	25	10	35	2732.84
#85	AHCTF1	24	8	32	102.06
#86	EDF1	24	9	33	5760.4
#87	FOXN2	24	16	40	15071.411
#88	NR1H2	24	19	43	1728.331
#89	OVOL1	24	12	36	12471.811
#90	TCF25	24	9	33	10113.666
#91	SPDEF	23	12	35	9642.532
#92	RCAN1	23	17	40	1577.637
#93	E2F7	23	15	38	576.338
#94	PROX1	22	15	37	14019.28
#95	FOSL2	22	15	37	788.257
#96	CEBPA	22	14	36	1617.216
#97	E2F5	22	10	32	297.94
#98	ELF4	22	13	35	2088.417
#99	SMAD1	22	10	32	297.711
#100	E2F8	22	10	32	518.86
#101	RBPJ	22	8	30	383.806
#102	KLF7	21	12	33	3055.309
#103	MAFK	21	10	31	1939.361
#104	ISX	21	20	41	1298.468
#105	TCF4	21	13	34	3381.057
#106	ZNF449	20	9	29	4005.006
#107	NR5A2	20	18	38	1246.311
#108	SP3	20	11	31	165.391
#109	NKX2-3	20	10	30	634.71
#110	ZRANB2	20	6	26	214.745
#111	AATF	20	14	34	433.977
#112	TSHZ1	20	11	31	524.428
#113	CBFA2T2	19	13	32	13151.823
#114	BLZF1	19	13	32	1953.37
#115	ZNF643	19	12	31	317.994
#116	ATF2	19	13	32	4843.104
#117	FOXA3	19	12	31	11195.294
#118	IRF3	19	13	32	473.561
#119	TAF4	19	6	25	99.458
#120	ZFHX3	19	17	36	1364.46
#121	RB1	19	10	29	135.584
#122	FOXK2	19	13	32	353.017
#123	ZNF281	18	16	34	2257.261
#124	PBX1	18	16	34	2169.588
#125	PITX1	18	18	36	489.083
#126	NCOR1	18	12	30	1767.614
#127	MTF1	18	14	32	1623.667
#128	SOX9	18	16	34	519.857
#129	STAT6	18	10	28	518.898
#130	TSHZ3	18	10	28	1460.285
#131	SMAD3	18	13	31	874.615
#132	ZNF639	18	9	27	1880.986
#133	MAX	18	11	29	390.733
#134	GAS7	18	6	24	414.086
#135	FOXF1	18	7	25	1274.855
#136	ZNF215	18	12	30	1841.908
#137	ARNTL	17	16	33	772.669
#138	HDAC2	17	12	29	1086.983
#139	ZEB2	17	6	23	729.868
#140	BCL11B	17	22	39	1407.289
#141	MSRB2	17	13	30	2231.446
#142	SREBF2	17	16	33	1523.035
#143	PEG3	17	7	24	133.272
#144	HMG20B	16	14	30	1108.266
#145	XBP1	16	20	36	1258.663
#146	MLX	16	9	25	253.088
#147	HOXD1	16	18	34	580.435
#148	UBN1	16	10	26	1422.228
#149	NFATC1	16	20	36	1872.971
#150	MYCN	16	15	31	833.439
#151	RUNX1T1	16	6	22	321.805
#152	MECOM	16	15	31	1550.967
#153	TFEC	16	15	31	1322.403
#154	PRDM2	16	12	28	1279.649
#155	SATB2	16	21	37	2912.208
#156	CITED1	15	13	28	1341.424
#157	TAF4B	15	19	34	2546.778
#158	LMO4	15	18	33	2601.343
#159	NR1I2	15	17	32	2536.301
#160	ADNP	15	13	28	902.523
#161	TAF5L	15	12	27	2147.237
#162	STAT5B	15	17	32	5874.554
#163	ZXDC	15	11	26	906.944
#164	TFE3	15	14	29	2870.569
#165	FLI1	15	4	19	1887.182
#166	GTF2IRD1	15	17	32	592.096
#167	TCF7L2	15	14	29	233.086
#168	FOXA2	15	20	35	993.361
#169	HNF1B	15	17	32	1092.481
#170	FOXN3	15	18	33	1057.729
#171	KLF5	15	16	31	792.898
#172	CIR1	14	11	25	793.957
#173	ZSCAN18	14	24	38	2746.998
#174	HOXA11	14	12	26	4459.825
#175	FOXM1	14	11	25	267.066
#176	ARID3A	14	12	26	750.985
#177	SCAND1	14	12	26	312.389
#178	ATOH1	14	13	27	3455.178
#179	HOXB2	14	19	33	1695.733
#180	ZC3H8	14	12	26	483.888
#181	PHTF1	14	10	24	1205.79
#182	CBFA2T3	14	18	32	1372.819
#183	BTAF1	14	14	28	8324.371
#184	NPAS2	14	8	22	678.802
#185	FOXO6	14	19	33	3340.345
#186	MYCL1	13	15	28	2584.014
#187	ZSCAN16	13	18	31	1618.232
#188	MSX1	13	16	29	350.289
#189	CEBPD	13	19	32	3697.961
#190	GRHL2	13	13	26	838.761
#191	C5orf41	13	20	33	1745.871
#192	HMGA2	13	17	30	2357.284
#193	ZNF193	13	12	25	1033.936
#194	BHLHE41	13	16	29	1667.774
#195	ZNF91	13	22	35	972.595
#196	PCGF6	13	16	29	3303.802
#197	PGR	13	8	21	123.748
#198	ETV4	13	16	29	1093.416
#199	CREBL2	13	18	31	1819.626
#200	TARDBP	13	6	19	280.082
#201	ZNF134	13	12	25	2375.229
#202	PGBD1	13	16	29	1027.213
#203	SMAD4	13	19	32	1145.31
#204	ZNF207	13	15	28	183.332
#205	GLI3	13	3	16	142.875
#206	SLC26A3	13	32	45	3544.736
#207	ELF1	13	16	29	1535.718
#208	HNF4G	12	19	31	2311.788
#209	PBX3	12	18	30	2747.869
#210	TFEB	12	16	28	648.962
#211	FBXW7	12	14	26	23944.388
#212	POU4F1	12	17	29	14017.617
#213	ZXDA	12	10	22	899.67
#214	ZNF277	12	14	26	268.497
#215	SLC30A9	12	22	34	4825.903
#216	SCML2	12	9	21	378.56
#217	WNT5A	12	13	25	5167.266
#218	CSRNP1	12	14	26	1520.461
#219	FOS	12	10	22	277.792
#220	TRIM28	12	13	25	374.867
#221	MEF2C	12	10	22	561.655
#222	ZNF268	12	12	24	1707.131
#223	HMGB2	12	12	24	186.332
#224	SOLH	12	14	26	199.565
#225	MEIS2	12	13	25	1762.807
#226	HES6	12	15	27	294.24
#227	ZKSCAN1	11	15	26	1080.979
#228	C11orf9	11	23	34	1812.487
#229	FOXF2	11	14	25	1849.872
#230	TAF5	11	15	26	4262.331
#231	TGIF1	11	16	27	192.429
#232	HOXA5	11	4	15	620.563
#233	MYBL2	11	15	26	1231.451
#234	TBX3	11	18	29	509.161
#235	ETV5	11	16	27	1619.946
#236	ZNF217	11	20	31	2316.157
#237	HOXA7	11	6	17	3265.91
#238	HOXC9	10	14	24	1333.746
#239	MEOX1	10	15	25	916.927
#240	MAF	10	10	20	401.788
#241	ZNF202	10	15	25	1887.606
#242	ZNF83	10	18	28	5815.512
#243	NOTCH1	10	17	27	2795.33
#244	IRF7	10	15	25	3321.097
#245	MLL	10	15	25	1096.721
#246	PLAG1	10	17	27	867.946
#247	SMAD2	10	17	27	3170.55
#248	ELK4	10	10	20	494.775
#249	TCF19	10	9	19	1084.843
#250	MEIS3P1	10	18	28	3122.88
#251	SIX1	10	13	23	24674.591
#252	MLLT10	10	16	26	636.931
#253	ZIC2	10	20	30	960.125
#254	GABPA	10	12	22	13698.862
#255	ATF1	10	14	24	889.97
#256	RUNX2	10	22	32	504.204
#257	YY1	10	14	24	194.427
#258	KDM5A	10	18	28	558.417
#259	CSDA	10	18	28	695.597
#260	MGA	10	15	25	1296.332
#261	JUNB	10	10	20	929.918
#262	ATF3	10	7	17	333.721
#263	FOXO3	10	16	26	692.551
#264	CREB3L4	10	13	23	1050.058
#265	STAT3	10	14	24	145.846
#266	ARID4A	10	11	21	145.473
#267	ENO1	10	20	30	1196.895
#268	GATAD2B	10	16	26	490.821
#269	KLF2	10	17	27	876.829
#270	PPARA	9	16	25	745.641
#271	RORA	9	14	23	899.188
#272	SOX6	9	27	36	1256.685
#273	GTF2H3	9	11	20	69.522
#274	NFIA	9	22	31	1649.976
#275	BCL3	9	15	24	2017.971
#276	TCF21	9	13	22	338.696
#277	PBX4	9	20	29	1201.474
#278	CREB3L1	9	17	26	8616.722
#279	CREB1	9	11	20	895.641
#280	FOSL1	9	13	22	1346.458
#281	TSC22D1	9	14	23	195.415
#282	ARNT	9	17	26	689.573
#283	NKX2-1	9	11	20	3918.382
#284	HOXB5	9	13	22	603.827
#285	TFAM	9	18	27	463.254
#286	ECSIT	9	17	26	994.699
#287	IRF8	9	17	26	1040.136
#288	HOXA9	9	6	15	2760.981
#289	EBF1	9	16	25	438.348
#290	HR	9	16	25	2543.771
#291	KLF11	9	15	24	397.061
#292	ZNF37A	9	11	20	5324.349
#293	NR1H4	9	18	27	2462.455
#294	TSHZ2	9	14	23	5772.643
#295	NR3C1	9	14	23	528.282
#296	CREB5	9	24	33	996.649
#297	JUND	9	17	26	1288.478
#298	HOXB13	9	19	28	1309.597
#299	MTA1	9	14	23	729.27
#300	RUNX1	9	18	27	985.12
#301	HOXD8	9	13	22	2153.116
#302	IRF2	9	12	21	191.14
#303	CDKN2A	8	15	23	848.948
#304	GATAD1	8	22	30	1091.965
#305	ZGPAT	8	12	20	2584.657
#306	TULP4	8	14	22	1909.126
#307	ZNF138	8	11	19	100.978
#308	KDM5B	8	14	22	4999.82
#309	HOXA1	8	13	21	1719.511
#310	NR4A1	8	14	22	501.121
#311	ETV6	8	16	24	6463.631
#312	EGR3	8	17	25	2299.301
#313	ISL1	8	23	31	4148.057
#314	BATF2	8	17	25	298.828
#315	KCNH8	8	20	28	2099.715
#316	SP4	8	18	26	291.262
#317	TFAP2A	8	24	32	4195.771
#318	NFIB	8	20	28	1003.87
#319	CTBP1	8	15	23	728.654
#320	IKZF1	8	9	17	4530.121
#321	SMAD5	8	13	21	661.031
#322	HLF	8	20	28	2943.205
#323	CREB3	8	12	20	2212.529
#324	PRRX1	8	7	15	590.088
#325	HOXD9	8	16	24	1589.293
#326	SALL1	7	16	23	1224.297
#327	PRDM1	7	15	22	840.959
#328	FOXD1	7	21	28	2502.466
#329	SIM2	7	15	22	774.813
#330	SNAI2	7	9	16	4956.21
#331	WT1	7	26	33	3029.874
#332	ELF3	7	17	24	14145.863
#333	ZFPM2	7	11	18	777.482
#334	EHF	7	13	20	2822.262
#335	NFATC2	7	17	24	962.476
#336	ZFP36L2	7	16	23	686.814
#337	ONECUT2	7	27	34	2428.08
#338	GLIS3	7	22	29	1926.304
#339	CREM	7	12	19	378.218
#340	FOXO1	7	23	30	1339.2
#341	ZNF93	7	14	21	3264.028
#342	NR2F2	7	21	28	1470.384
#343	TSC22D3	7	15	22	1034.535
#344	ELK3	7	26	33	888.237
#345	ZHX1	7	13	20	357.585
#346	HOXB6	7	14	21	1470.539
#347	HOXD13	7	17	24	1464.69
#348	PA2G4	7	13	20	622.137
#349	FOSB	7	9	16	1222.95
#350	ZNF140	7	11	18	2048.333
#351	ZNF274	7	16	23	2411.434
#352	HOXA3	7	11	18	782.511
#353	MSX2	7	20	27	966.53
#354	RARB	7	10	17	3461.444
#355	SUPT4H1	7	15	22	7162.578
#356	ZNF238	7	15	22	3955.801
#357	MYT1	7	22	29	3565.364
#358	RERE	7	14	21	662.275
#359	HOXA10	7	7	14	405.096
#360	ZHX2	7	20	27	644.121
#361	THRB	7	16	23	244.615
#362	FOXP2	7	20	27	578.5
#363	HOXA2	7	16	23	408.627
#364	NR2F1	6	20	26	1081.927
#365	ARNT2	6	18	24	7743.354
#366	TFDP2	6	15	21	295.972
#367	SOX12	6	13	19	220.862
#368	ATF7	6	13	19	659.227
#369	NFAT5	6	18	24	662.353
#370	SMAD6	6	19	25	1168.603
#371	ELF5	6	19	25	2147.417
#372	RORC	6	24	30	606.057
#373	NANOGNB	6	17	23	757.757
#374	HOXD11	6	10	16	324.048
#375	ZFP90	6	19	25	158.793
#376	ST18	6	20	26	3352.659
#377	BTG2	6	12	18	3842.734
#378	IRX3	6	11	17	1786.111
#379	AFF4	6	13	19	187.727
#380	TCF12	6	12	18	415.706
#381	HMBOX1	6	20	26	807.552
#382	C1orf85	6	19	25	1191.58
#383	FOXA1	6	17	23	646.417
#384	NFYA	6	21	27	456.852
#385	AHR	6	22	28	720.422
#386	ZNF70	6	19	25	250.164
#387	AEBP1	6	11	17	390.384
#388	ZNF81	6	19	25	690.055
#389	TWIST1	6	13	19	227.309
#390	SATB1	6	18	24	1320.095
#391	DLX6	6	13	19	914.078
#392	ZNF133	6	15	21	749.077
#393	IRF1	6	13	19	1132.096
#394	HOXB8	6	14	20	264.674
#395	CEBPB	6	15	21	152.659
#396	ZBTB38	5	10	15	302.123
#397	HES1	5	12	17	138.182
#398	ETS2	5	13	18	307.154
#399	ZFP36L1	5	17	22	448.27
#400	TEAD2	5	22	27	1687.324
#401	ZNF33B	5	30	35	231.056
#402	NR1H3	5	19	24	173.436
#403	HOXD4	5	14	19	750.846
#404	FOXC2	5	18	23	824.015
#405	LASS6	5	19	24	2741.531
#406	DDIT3	5	13	18	505.173
#407	NR4A2	5	12	17	1120.551
#408	MKX	5	21	26	601.466
#409	NFE2L2	5	16	21	1436.845
#410	ETS1	5	11	16	127.946
#411	KLF10	5	16	21	1918.789
#412	TFAP2C	5	26	31	1038.875
#413	STAT4	5	10	15	621.26
#414	PAX7	5	11	16	610.085
#415	TCF3	5	22	27	772.993
#416	ESRRG	5	19	24	1996.667
#417	EN2	4	16	20	503.156
#418	FOXC1	4	26	30	646.114
#419	TAF12	4	16	20	254.757
#420	MEF2A	4	10	14	39.633
#421	YBX1	4	24	28	553.76
#422	PCGF2	4	16	20	1595.986
#423	TSC22D2	4	14	18	1346.656
#424	HOXB9	4	11	15	341.071
#425	GATA6	4	14	18	4517.483
#426	PPARG	4	20	24	459.13
#427	HCLS1	4	19	23	271.955
#428	RFX5	4	16	20	437.558
#429	EGR1	4	8	12	1090.881
#430	SOX8	4	26	30	1761.639
#431	SOX1	4	22	26	1370.209
#432	ZNF323	4	14	18	1223.558
#433	DMRT1	4	18	22	4575.022
#434	MAFB	4	13	17	2014.471
#435	POU2F3	4	24	28	8639.11
#436	BCL6	4	17	21	491.673
#437	ZNF256	4	19	23	591.504
#438	SOX7	4	19	23	769.867
#439	ETV7	4	18	22	1266.316
#440	HEY1	4	20	24	314.634
#441	L3MBTL4	4	27	31	2229.215
#442	CSRNP3	4	29	33	1313.92
#443	SREBF1	4	18	22	1607.459
#444	PLSCR1	4	18	22	496.185
#445	TRIM29	4	17	21	181.378
#446	PAX6	4	19	23	1522.337
#447	HOPX	3	11	14	1580.638
#448	ZNF165	3	23	26	1937.862
#449	JUN	3	15	18	1195.73
#450	SOX30	3	19	22	308.005
#451	BHLHE40	3	20	23	71.279
#452	IRF9	3	13	16	705.552
#453	PURB	3	18	21	108.606
#454	ZNF167	3	20	23	264.62
#455	MAFF	3	13	16	93.016
#456	SPEN	3	13	16	429.379
#457	ZFP37	3	15	18	28.239
#458	SOX2	3	22	25	5499.41
#459	IRF5	3	18	21	581.346
#460	FOXK1	3	15	18	178.418
#461	NEUROD1	3	11	14	418.459
#462	NR1D2	3	23	26	245.84
#463	ZIC1	3	13	16	137.794
#464	ZNF75D	3	13	16	676.173
#465	NFATC3	3	20	23	431.286
#466	ERG	2	17	19	97.027
#467	GTF2H2	2	20	22	174.76
#468	HOXA6	2	7	9	91.459
#469	HOXB7	2	15	17	1053.364
#470	PITX2	2	20	22	419.947
#471	CNOT7	2	19	21	55.724
#472	CBL	2	14	16	178.831
#473	NR4A3	2	22	24	442.551
#474	EGR4	2	14	16	926.596
#475	HMGB1	2	24	26	1067.148
#476	KLF3	2	22	24	806.331
#477	HOXB3	2	12	14	568.386
#478	TRIM22	2	17	19	308.853
#479	HOXD10	2	12	14	39.695
#480	GATA2	2	20	22	201.115
#481	HOXA13	2	13	15	2155.651
#482	SMAD9	2	32	34	1179.829
#483	ZNF85	1	23	24	110.289
#484	BACH2	1	12	13	351.347
#485	GRHL3	1	23	24	2571.507
#486	ZNF232	1	26	27	43.555
#487	DMRT2	1	22	23	925.472
#488	HHEX	1	14	15	28.437
#489	ARX	1	14	15	20.981
#490	RBCK1	1	24	25	667.854
#491	MESP1	1	21	22	93.014
#492	KLF12	1	28	29	543.266
#493	CTNNB1	1	17	18	317.187
#494	TP53	1	21	22	2129.725
#495	EGR2	1	16	17	92.374
#496	RUNX3	1	23	24	3320.822
#497	FOXG1	0	20	20	0
#498	CREB3L2	0	28	28	0
#499	SCAND3	0	25	25	0
#500	IRX2	0	25	25	0