Hub Rank	Node	Children	Parents	Degree	Betweenness
#1	RUNX2	56	3	59	587.711
#2	ZNF367	56	2	58	154.211
#3	NFKB1	50	12	62	5734.063
#4	HCLS1	49	2	51	234.241
#5	SALL2	48	10	58	2347.467
#6	IRF8	46	2	48	316.749
#7	MNT	45	3	48	1470.22
#8	KLF4	45	4	49	501.595
#9	PBX1	43	1	44	157.352
#10	TCEAL1	43	8	51	1633.722
#11	BTG2	43	8	51	2060.863
#12	CEBPB	41	7	48	512.507
#13	CREB5	41	4	45	247.286
#14	GLI3	41	11	52	2016.301
#15	MEIS2	41	16	57	3563.827
#16	CSRNP1	40	3	43	376.85
#17	GABPB1	39	12	51	4078.35
#18	TCF19	39	5	44	3686.739
#19	CREB3L1	38	8	46	726.524
#20	ETV3	38	5	43	313.73
#21	JUNB	38	3	41	221.235
#22	JUND	37	7	44	1532.362
#23	ELK3	37	6	43	1399.904
#24	ELF1	36	10	46	2142.264
#25	VAV1	36	4	40	265.106
#26	BCL3	36	6	42	255.905
#27	PTTG1	35	1	36	32.754
#28	MAX	35	7	42	617.898
#29	MBD1	35	2	37	174.554
#30	NFIA	35	9	44	2088.489
#31	FOSL1	35	10	45	633.678
#32	ELF4	35	15	50	4420.378
#33	EGR4	35	5	40	1678.211
#34	GAS7	35	10	45	619.478
#35	NFIX	34	8	42	670.963
#36	TCF4	34	10	44	1330.033
#37	GATAD2B	33	7	40	621.517
#38	KLF3	33	6	39	1080.261
#39	NOLC1	33	5	38	817.409
#40	TRIM22	32	9	41	6606.057
#41	SP1	32	3	35	314.59
#42	FOXO1	32	16	48	2476.828
#43	HMGA1	32	7	39	2119.524
#44	KLF6	31	7	38	251.159
#45	CREBL2	31	11	42	1375.502
#46	ARX	31	6	37	4313.614
#47	FOXN3	31	7	38	658.973
#48	HIC1	30	6	36	352.678
#49	STAT5A	30	9	39	585.859
#50	TWIST1	30	13	43	4026.107
#51	MEIS1	30	8	38	1024.227
#52	UHRF1	30	6	36	250.487
#53	SP3	30	6	36	737.845
#54	CREB1	30	3	33	321.465
#55	IRF1	30	5	35	4006.163
#56	KDM5B	29	10	39	2305.96
#57	MYC	29	7	36	1084.832
#58	GTF2I	29	3	32	987.52
#59	ZNF397	29	12	41	1698.399
#60	ZHX2	29	14	43	1146.977
#61	ATF3	28	2	30	299.75
#62	JDP2	28	8	36	414.576
#63	SOX8	28	14	42	2257.833
#64	MAFF	28	7	35	508.567
#65	KLF15	27	12	39	1954.589
#66	TFAM	27	12	39	819.35
#67	HMGB2	27	2	29	1527.46
#68	BATF	27	7	34	270.655
#69	TAF5L	27	14	41	1637.073
#70	EBF1	27	8	35	450.844
#71	NR3C2	27	9	36	1223.359
#72	SMAD3	26	8	34	841.282
#73	TCF7L1	26	10	36	416.795
#74	ETS2	26	15	41	963.48
#75	RELA	26	8	34	854.852
#76	CCRN4L	26	8	34	630.856
#77	MAFB	26	15	41	1335.367
#78	FOSL2	25	14	39	1963.257
#79	C11orf9	25	4	29	62.161
#80	ETV6	25	13	38	1889.887
#81	AHR	25	13	38	3422.43
#82	LZTS1	25	16	41	2121.98
#83	TCF7L2	25	14	39	1259.893
#84	ZSCAN18	25	11	36	987.528
#85	YEATS4	24	15	39	4039.015
#86	FOXM1	24	2	26	540.163
#87	KLF2	24	10	34	1391.803
#88	NFKB2	24	11	35	673.88
#89	RUNX1	24	16	40	1649.987
#90	C5orf41	24	10	34	958.061
#91	TFEC	24	5	29	128.765
#92	ZNF24	24	9	33	638.919
#93	FOXF1	23	13	36	1743.22
#94	ATF1	23	8	31	571.498
#95	SIX5	23	9	32	1176.278
#96	TCF12	23	13	36	2476.936
#97	TRERF1	23	15	38	1084.196
#98	THRA	23	10	33	850.051
#99	NFIL3	23	8	31	1285.249
#100	IKZF4	23	12	35	2292.49
#101	RELB	23	12	35	1078.952
#102	PLSCR1	23	11	34	3006.332
#103	ETS1	22	15	37	643.052
#104	REL	22	12	34	882.102
#105	PRDM1	22	14	36	1229.422
#106	C1orf85	22	14	36	1987.4
#107	PEG3	22	13	35	2065.989
#108	STAT1	22	3	25	35.402
#109	LEF1	22	17	39	2120.508
#110	TBX1	22	11	33	2009.639
#111	SATB1	22	14	36	1195.349
#112	HLF	22	10	32	560.149
#113	IRF7	21	6	27	2152.691
#114	VDR	21	10	31	951.855
#115	HOXA3	21	13	34	1539.637
#116	SIX1	21	12	33	2349.166
#117	E2F7	21	7	28	116.759
#118	CBFA2T2	21	13	34	877.772
#119	ZEB2	21	16	37	810.936
#120	NR2F2	21	12	33	690.855
#121	CEBPD	21	15	36	1155.744
#122	HOXC13	21	15	36	3289.787
#123	HEY2	20	15	35	1681.062
#124	FOSB	20	4	24	313.077
#125	SPEN	20	5	25	229.655
#126	TSHZ1	20	15	35	1125.177
#127	GABPA	20	7	27	240.764
#128	RERE	20	8	28	3161.306
#129	MGA	20	10	30	1236.209
#130	GCFC1	20	10	30	839.754
#131	ZNF217	20	17	37	1821.258
#132	TSC22D4	20	12	32	1110.977
#133	CEBPA	19	8	27	205.751
#134	MYOD1	19	3	22	492.187
#135	SOX4	19	15	34	1723.45
#136	PKNOX2	19	18	37	1988.601
#137	HSF2	19	13	32	3949.489
#138	MITF	19	26	45	4438.575
#139	RB1	19	12	31	1027.084
#140	LHX5	19	7	26	295.945
#141	TEAD3	19	12	31	529.436
#142	IKZF1	19	4	23	42.352
#143	PBX2	18	13	31	1342.976
#144	FOXL2	18	9	27	1336.263
#145	SMAD2	18	11	29	2206.006
#146	SUPT6H	18	9	27	311.184
#147	MEF2C	18	18	36	2025.353
#148	ATF2	18	6	24	101.38
#149	MMP14	18	18	36	1883.614
#150	NFX1	18	6	24	1434.3
#151	ZNF281	17	23	40	2776.244
#152	KLF11	17	24	41	3608.881
#153	NR3C1	17	17	34	1583.298
#154	HOXC9	17	12	29	830.237
#155	DLX2	17	6	23	4183.268
#156	FOS	17	1	18	3290.946
#157	ZNF238	17	22	39	3683.986
#158	CSDA	17	16	33	2364.434
#159	JUN	17	15	32	1633.478
#160	PPARG	16	12	28	881.17
#161	HDAC1	16	12	28	1314.056
#162	HOXA5	16	10	26	433.329
#163	ZNF207	16	10	26	1485.778
#164	GLIS3	16	19	35	1655.848
#165	HOXC11	16	10	26	1224.055
#166	FOXL1	16	17	33	745.976
#167	NFIB	16	11	27	610.732
#168	MYCN	16	14	30	2827.076
#169	HMG20B	16	14	30	1128.072
#170	CITED2	16	15	31	804.302
#171	CTNNB1	16	13	29	2147.491
#172	PRRX2	16	15	31	1333.949
#173	TARDBP	16	17	33	948.256
#174	TEAD4	16	18	34	1658.877
#175	GATA3	16	10	26	850.212
#176	SOX6	15	20	35	2327.733
#177	BHLHE40	15	18	33	648.493
#178	HOXC4	15	11	26	621.34
#179	MKX	15	22	37	2080.259
#180	PBX3	15	25	40	3536.384
#181	EPAS1	15	14	29	1149.414
#182	BCL6	15	14	29	883.892
#183	BATF3	15	15	30	1950.199
#184	FOXO6	15	21	36	2163.29
#185	KLF9	15	13	28	991.965
#186	ZNF83	15	13	28	1571.863
#187	SCMH1	15	24	39	1693.36
#188	TFAP2A	15	14	29	812.98
#189	SNAI2	15	11	26	1170.481
#190	ZKSCAN1	15	16	31	1483.78
#191	SIX4	14	19	33	1113.506
#192	ARNTL2	14	15	29	865.788
#193	HOXA10	14	8	22	291.137
#194	AHCTF1	14	23	37	709.17
#195	ADNP2	14	12	26	689.869
#196	IRX4	14	11	25	1175.44
#197	TEAD2	14	17	31	1437.736
#198	HES1	14	19	33	1277.91
#199	ZHX1	14	13	27	1588.828
#200	RUNX1T1	14	18	32	3953.364
#201	TRPS1	14	23	37	2782.661
#202	PCGF2	14	19	33	1904.386
#203	NR1H3	14	9	23	342.58
#204	ETV5	14	15	29	1285.002
#205	HNF1A	14	6	20	126.839
#206	RCAN1	14	20	34	2282.45
#207	SOX11	14	15	29	1915.008
#208	TAF5	14	10	24	1452.873
#209	SOX17	14	8	22	1920.869
#210	BATF2	14	10	24	1401.46
#211	HOXB2	14	13	27	1014.576
#212	BACH2	13	15	28	852.163
#213	STAT4	13	14	27	1866.135
#214	NFATC2	13	13	26	927.14
#215	HOPX	13	25	38	2146.53
#216	ZSCAN2	13	17	30	472.269
#217	E2F8	13	7	20	102.543
#218	TCF3	13	19	32	2878.089
#219	TULP4	13	12	25	903.736
#220	DLX1	13	11	24	1228.014
#221	PRRX1	13	20	33	1080.851
#222	ZNF187	13	20	33	2453.749
#223	NFIC	13	10	23	768.499
#224	CSRNP3	13	16	29	1119.074
#225	ZNF91	12	19	31	2171.156
#226	TBX15	12	14	26	764.782
#227	HOXD8	12	17	29	1817.59
#228	FLI1	12	10	22	634.04
#229	MSRB2	12	21	33	908.222
#230	EGR2	12	12	24	4590.871
#231	AEBP1	12	15	27	1385.647
#232	TWIST2	12	24	36	901.591
#233	CREM	12	8	20	1234.235
#234	NFYC	12	13	25	427.067
#235	ZFP90	12	24	36	2714.005
#236	MYBL2	12	7	19	275.524
#237	MYF5	12	13	25	7105.192
#238	PRDM2	12	17	29	583.777
#239	HIF3A	12	14	26	699.933
#240	NCOR1	12	17	29	1756.258
#241	SIX2	12	18	30	541.679
#242	STAT3	12	11	23	743.859
#243	MLL	12	8	20	816.315
#244	EN1	12	13	25	1570.661
#245	ETV1	11	17	28	883.441
#246	PGR	11	18	29	1133.434
#247	EOMES	11	6	17	36.159
#248	HHEX	11	8	19	240.353
#249	ZEB1	11	10	21	2040.674
#250	HOXD13	11	20	31	1310.296
#251	IRF4	11	13	24	622.361
#252	ZNF93	11	14	25	898.614
#253	TSHZ3	11	22	33	3302.1
#254	PAX7	11	9	20	935.268
#255	HOXB3	11	20	31	1199.132
#256	STAT6	11	19	30	2120.719
#257	TAF4B	11	18	29	429.087
#258	CBL	11	6	17	229.49
#259	CSRNP2	11	15	26	512.269
#260	FOXP4	11	21	32	894.975
#261	SOLH	11	15	26	841.078
#262	UBN1	11	12	23	622.876
#263	ZFPM2	11	16	27	467.368
#264	FUBP1	11	19	30	2225.342
#265	NOTCH1	11	21	32	1454.213
#266	STAT5B	11	10	21	608.739
#267	MEOX2	11	22	33	2029.979
#268	WNT5A	11	18	29	940.781
#269	IRF9	11	7	18	841.073
#270	TFEB	11	20	31	1657.953
#271	NANOG	11	20	31	733.185
#272	TFCP2	11	7	18	301.884
#273	ZFP37	10	22	32	2591.158
#274	NFAT5	10	12	22	571.606
#275	CNOT7	10	16	26	1139.675
#276	ZNF117	10	15	25	414.15
#277	NANOGNB	10	12	22	646.239
#278	ZIC2	10	10	20	1146.081
#279	NFATC1	10	14	24	588.838
#280	ZNF75D	10	16	26	906.299
#281	GLI2	10	16	26	2726.688
#282	ZNF18	10	15	25	947.587
#283	SP140	10	9	19	76.221
#284	SMAD1	10	20	30	1114.926
#285	SIM2	10	17	27	1874.049
#286	ENO1	10	16	26	474.971
#287	ZBTB38	10	15	25	787.701
#288	ZNF639	10	13	23	979.565
#289	ZNF167	10	21	31	1583.065
#290	KLF12	10	15	25	567.443
#291	NFYA	10	23	33	2064.564
#292	PHTF1	10	17	27	775.788
#293	ZNF434	10	14	24	775.876
#294	GATA2	10	21	31	1114.159
#295	PLAG1	10	13	23	1400.65
#296	E2F3	10	19	29	1173.276
#297	TSC22D1	10	20	30	1578.342
#298	ESRRG	10	18	28	2554.878
#299	SMAD9	10	21	31	762.69
#300	NPAS2	9	16	25	721.459
#301	FOXC2	9	14	23	990.286
#302	ZFHX4	9	19	28	1222
#303	DLX6	9	19	28	3087.244
#304	SOX7	9	14	23	813.342
#305	TGIF2	9	20	29	1961.808
#306	MSC	9	22	31	1092.62
#307	BCL11B	9	14	23	659.475
#308	EGR3	9	10	19	539.423
#309	HEY1	9	19	28	1085.311
#310	IRX3	9	19	28	1265.875
#311	EGR1	9	6	15	276.585
#312	TSHZ2	9	27	36	860.146
#313	DLX4	9	10	19	2205.062
#314	ZNF277	9	9	18	974.455
#315	GLIS2	9	18	27	1295.945
#316	SNAPC4	9	12	21	383.239
#317	HOXA9	9	10	19	665.757
#318	HOXA7	9	16	25	1358.813
#319	HOXA1	9	20	29	1362.391
#320	NKX3-1	9	16	25	1637.279
#321	HOXA13	9	8	17	1037.06
#322	MEIS3P1	9	19	28	1007.284
#323	CREB3L4	9	12	21	1156.435
#324	PROX1	9	7	16	517.509
#325	E2F1	9	11	20	4878.611
#326	E2F6	9	13	22	486.412
#327	NKX2-5	9	20	29	1328.733
#328	NFXL1	9	22	31	1381.626
#329	STRN3	9	12	21	2059.036
#330	CBFB	8	18	26	796.798
#331	HOXA11	8	11	19	735.444
#332	NFE2L3	8	10	18	834.06
#333	TCFL5	8	22	30	1812.747
#334	SMAD4	8	13	21	1149.671
#335	MYF6	8	4	12	120.347
#336	ZNF45	8	18	26	2280.319
#337	CDKN2A	8	19	27	959.679
#338	KLF7	8	20	28	1114.497
#339	ESR1	8	18	26	677.306
#340	MAFK	8	19	27	991.075
#341	ZNF496	8	13	21	850.832
#342	ZNF33A	8	13	21	446.206
#343	NR4A2	8	7	15	540.332
#344	AFF4	8	16	24	700.872
#345	LHX2	8	26	34	729.225
#346	SALL1	8	23	31	1467.663
#347	XBP1	8	15	23	395.344
#348	ZGPAT	8	22	30	270.592
#349	RBCK1	7	16	23	599.849
#350	HOXD4	7	18	25	648.042
#351	ZNF232	7	17	24	547.383
#352	MLLT10	7	19	26	1070.949
#353	RORB	7	12	19	1066.386
#354	ZFP36L2	7	15	22	570.499
#355	IRF6	7	17	24	2813.184
#356	SMAD5	7	12	19	249.725
#357	FOXS1	7	11	18	494.187
#358	ZNF202	7	21	28	1346.568
#359	HES6	7	20	27	678.504
#360	ZFHX3	7	20	27	1654.065
#361	ZNF500	7	22	29	697.469
#362	NFATC4	7	16	23	1696.495
#363	IRX2	7	21	28	2151.471
#364	TFDP1	7	13	20	471.739
#365	GATA6	7	16	23	709.943
#366	ALX1	7	19	26	1759.281
#367	POU6F1	7	14	21	670.064
#368	PAX6	7	13	20	448.999
#369	BLZF1	7	16	23	761.874
#370	RFX5	7	22	29	1031.436
#371	TCF7	7	23	30	886.003
#372	STAT2	7	13	20	382.625
#373	ELK1	7	20	27	780.414
#374	CBFA2T3	7	15	22	1026.022
#375	GTF2H4	7	11	18	453.038
#376	PHF5A	7	16	23	376.957
#377	MEF2A	7	13	20	1042.701
#378	CREB3	7	16	23	673.519
#379	HOXB6	7	15	22	1183.16
#380	TFDP2	6	15	21	376.231
#381	NR1H4	6	14	20	1184.548
#382	BNC1	6	16	22	2667.387
#383	MYNN	6	18	24	914.369
#384	MEOX1	6	21	27	1369.988
#385	SATB2	6	25	31	2277.136
#386	ZSCAN12	6	18	24	583.9
#387	ZNF133	6	13	19	444.265
#388	SOX2	6	16	22	1809.494
#389	RXRG	6	18	24	288.235
#390	CREBZF	6	16	22	620.463
#391	RARB	6	19	25	1514.881
#392	ARNT2	6	24	30	4432.981
#393	TFAP2C	6	25	31	3367.905
#394	MAF	6	22	28	822.161
#395	NR2C1	6	14	20	455.265
#396	TSC22D3	6	14	20	655.206
#397	FOXK2	6	16	22	430.024
#398	HMGA2	6	14	20	537.873
#399	DBP	6	20	26	1497.392
#400	ZNF498	6	13	19	563.696
#401	RUNX3	6	15	21	470.705
#402	MSX2	6	20	26	724.872
#403	ZNF287	6	20	26	646.044
#404	ISL1	6	26	32	910.609
#405	BHLHE41	5	18	23	251.747
#406	TBX5	5	22	27	273.97
#407	TEF	5	14	19	540.663
#408	HOXB7	5	19	24	458.966
#409	NR4A1	5	7	12	67.278
#410	TCF21	5	22	27	896.206
#411	SLC2A4RG	5	18	23	921.074
#412	FOXQ1	5	17	22	653.979
#413	FOXD1	5	21	26	599.731
#414	SOX13	5	20	25	1183.313
#415	L3MBTL4	5	27	32	1651.041
#416	ZNF438	5	21	26	669.48
#417	MXD1	5	11	16	77.682
#418	PITX2	5	18	23	1526.307
#419	IRX1	5	23	28	906.778
#420	TAF1B	5	20	25	795.403
#421	ZIC1	5	22	27	1067.813
#422	ZNF148	5	12	17	259.991
#423	NR4A3	5	11	16	581.186
#424	HOXC10	5	13	18	166.314
#425	SCML1	5	28	33	1363.083
#426	MYPOP	5	16	21	846.587
#427	MECOM	5	18	23	597.274
#428	HOXA2	4	15	19	145.293
#429	TBX3	4	16	20	608.05
#430	IRX5	4	19	23	766.743
#431	ZXDC	4	17	21	401.714
#432	ZC3H8	4	16	20	397.841
#433	FOXP1	4	29	33	1177.806
#434	GTF2IRD1	4	17	21	390.235
#435	DDIT3	4	19	23	1696.345
#436	TRIM29	4	17	21	993.537
#437	HOXD1	4	14	18	582.742
#438	ZNF268	4	12	16	177.512
#439	ZNF131	4	16	20	225.385
#440	MEIS3	4	22	26	583.969
#441	ZNF70	4	25	29	276.595
#442	ERF	4	13	17	430.66
#443	ERG	4	15	19	327.27
#444	TP53	4	24	28	4473.802
#445	HMBOX1	4	20	24	239.317
#446	LHX6	4	13	17	1256.789
#447	ONECUT2	4	18	22	961.626
#448	LHX8	4	17	21	266.681
#449	TGIF1	3	17	20	207.72
#450	ZNF140	3	17	20	604.326
#451	FOXG1	3	26	29	1057.249
#452	HOXD3	3	15	18	479.485
#453	ZNF323	3	19	22	848.415
#454	RORA	3	21	24	277.083
#455	NR1D2	3	23	26	327.816
#456	ZNF274	3	17	20	486.389
#457	ATF7	3	22	25	315.515
#458	FOXF2	3	23	26	320.911
#459	TBX2	3	22	25	408.406
#460	NFYB	3	24	27	500.723
#461	HOXD11	3	11	14	390.98
#462	NFATC3	3	17	20	396.294
#463	AR	3	15	18	171.881
#464	WT1	3	24	27	568.169
#465	ATF6	3	15	18	774.372
#466	ZHX3	3	26	29	846.147
#467	ARNT	3	14	17	95.099
#468	FOXC1	3	25	28	650.223
#469	KDM5A	3	15	18	645.207
#470	PAX8	3	15	18	1842.389
#471	RARA	3	25	28	2369.562
#472	PPARA	3	13	16	652.607
#473	HEYL	3	18	21	381.119
#474	ZBTB25	3	25	28	831.074
#475	NR2F1	2	22	24	424.532
#476	SREBF1	2	19	21	71.143
#477	ATF5	2	27	29	343.945
#478	TP63	2	17	19	406.567
#479	SIM1	2	17	19	1168.389
#480	HOXD10	2	16	18	103.587
#481	C12orf28	2	17	19	98.172
#482	SIN3A	2	23	25	2009.587
#483	LMO4	2	17	19	720.231
#484	LHX9	2	22	24	518.422
#485	PAX3	2	27	29	1236.704
#486	SMAD6	2	25	27	563.941
#487	KLF5	2	21	23	124.704
#488	DMRT2	1	19	20	130.247
#489	ARNTL	1	18	19	47.682
#490	SLC30A9	1	22	23	731.909
#491	IRF5	1	7	8	18.592
#492	CTBP1	1	20	21	687.62
#493	SREBF2	1	11	12	25.817
#494	THRB	1	18	19	91.026
#495	FOXP2	1	23	24	202.439
#496	SOX9	1	29	30	193.451
#497	SIX3	1	17	18	289.186
#498	LASS6	1	26	27	226.211
#499	MSX1	1	28	29	210.288
#500	ZFP36L1	1	20	21	86.402