Hub Rank	Node	Children	Parents	Degree	Betweenness
#1	FOXA1	86	1	87	31.307
#2	XBP1	72	3	75	649.976
#3	STAT3	70	2	72	389.965
#4	FOXO3	62	3	65	4554.412
#5	AR	61	3	64	169.331
#6	ESR1	58	5	63	1031.548
#7	GATA3	58	5	63	457.191
#8	ENO1	58	3	61	39.364
#9	NFYC	54	1	55	367.854
#10	JUND	53	4	57	68.925
#11	YBX1	52	6	58	1630.432
#12	TFAP2A	52	9	61	3989.059
#13	HCLS1	51	5	56	3492.969
#14	STAT1	50	12	62	1083.248
#15	CEBPB	50	3	53	96.45
#16	PA2G4	49	6	55	242.898
#17	E2F3	47	8	55	5883.528
#18	FOXN3	46	7	53	2738.078
#19	HMG20B	46	4	50	516.956
#20	BCL6	43	7	50	869.971
#21	NFIL3	43	7	50	656.76
#22	NFATC3	42	13	55	3402.423
#23	SPDEF	42	7	49	137.814
#24	KLF6	41	10	51	751.933
#25	GATAD1	40	7	47	556.382
#26	TFDP1	40	8	48	807.841
#27	FOXC1	40	3	43	3962.323
#28	PLSCR1	39	9	48	535.329
#29	BHLHE40	39	8	47	320.101
#30	PRRX1	38	7	45	2111.467
#31	ZNF24	38	10	48	2943.657
#32	EN1	38	7	45	445.437
#33	IRF8	38	1	39	115.981
#34	LASS6	38	5	43	148.967
#35	TCF7L1	37	7	44	585.649
#36	SOX10	37	6	43	633.4
#37	BHLHE41	37	6	43	809.545
#38	SNAI2	37	10	47	972.063
#39	SUPT6H	36	13	49	553.447
#40	KLF9	36	15	51	3007.195
#41	ELF5	35	10	45	468.537
#42	MBD1	35	8	43	404.755
#43	ZNF91	34	14	48	1272.262
#44	NR2F1	33	12	45	2173.177
#45	RORC	33	12	45	371.919
#46	NPAT	33	17	50	3516.026
#47	CITED2	33	10	43	948.78
#48	FLI1	32	7	39	1284.094
#49	NFYA	32	13	45	5295.107
#50	MYBL2	32	7	39	694.659
#51	HAND1	32	15	47	3668.251
#52	TRIM22	32	4	36	214.421
#53	MEIS2	32	9	41	523.674
#54	TFCP2	32	13	45	4660.655
#55	FOXM1	32	7	39	73.354
#56	ZNF238	32	18	50	2702
#57	CDKN2A	31	13	44	7482.094
#58	E2F8	31	11	42	1387.978
#59	ZFPM2	31	7	38	2728.637
#60	KLF5	31	10	41	535.279
#61	HMGA1	30	12	42	3318.956
#62	ZXDC	30	20	50	2819.616
#63	HHEX	30	18	48	3818.299
#64	LMO4	30	9	39	6389.444
#65	CTBP1	30	9	39	137.661
#66	ZGPAT	30	15	45	889.302
#67	HOXA5	30	4	34	255.097
#68	RUNX3	30	7	37	625.853
#69	MEOX2	30	13	43	789.093
#70	PTTG1	30	7	37	284.23
#71	MMP14	29	11	40	407.869
#72	ZEB2	29	7	36	253.039
#73	TFEB	28	13	41	11537.051
#74	MSRB2	28	10	38	259.58
#75	HEY1	27	22	49	1573.871
#76	SP140	27	10	37	2093.243
#77	HSF1	27	12	39	1732.045
#78	IKZF1	27	6	33	206.178
#79	TAF12	26	18	44	430.098
#80	ZNF167	26	15	41	2127.17
#81	ZNF444	26	12	38	3084.742
#82	AEBP1	25	7	32	375.91
#83	NFE2L3	25	8	33	1248.936
#84	SOX4	25	14	39	1552.331
#85	MAF	25	14	39	747.658
#86	IRX5	25	17	42	1529.433
#87	NR3C1	24	10	34	425.072
#88	TFEC	24	4	28	172.052
#89	EVX1	24	13	37	1419.283
#90	BCL11B	24	12	36	304.795
#91	CSDA	24	17	41	951.299
#92	ZNF446	24	18	42	1356.081
#93	NFIB	23	11	34	177.443
#94	NFKB2	23	16	39	1394.045
#95	GATA2	23	14	37	634.281
#96	SATB1	23	20	43	1307.878
#97	TBX19	23	5	28	87.248
#98	TWIST1	23	16	39	649.75
#99	TRPS1	23	9	32	524.982
#100	RELA	22	11	33	389.111
#101	ZNF135	22	11	33	1694.453
#102	MYC	22	16	38	2051.459
#103	HOXA1	22	15	37	1030.323
#104	PBX1	22	19	41	815.497
#105	C2orf3	22	19	41	1097.372
#106	EGR1	22	8	30	526.999
#107	TCF7L2	22	12	34	778.894
#108	MAFF	22	16	38	629.223
#109	CBFB	22	12	34	2686.463
#110	BCL3	22	16	38	761.851
#111	GAS7	22	18	40	646.624
#112	REST	21	19	40	1631.834
#113	ZFHX3	21	8	29	429.402
#114	STAT6	21	9	30	398.198
#115	SUPT4H1	21	17	38	1369.498
#116	E2F1	21	12	33	1623.428
#117	ZBTB48	21	19	40	2653.062
#118	SOX18	21	11	32	1197.314
#119	TP73	21	14	35	1830.449
#120	PPARG	21	17	38	622.071
#121	HOXA7	21	15	36	1782.937
#122	SOX11	21	9	30	277.212
#123	MZF1	21	10	31	266.963
#124	NR2F2	21	16	37	1034.976
#125	TP53	20	16	36	354.177
#126	RUNX1T1	20	18	38	1051.146
#127	E2F4	20	16	36	902.725
#128	ELF1	20	17	37	1921.905
#129	GTF2I	20	13	33	3222.561
#130	SNAPC4	20	15	35	789.313
#131	NR3C2	20	20	40	853.859
#132	ATF6B	20	14	34	1005.524
#133	HOXA9	20	7	27	1052.736
#134	ZSCAN18	19	12	31	1008.447
#135	TFCP2L1	19	19	38	1150.036
#136	CEBPA	19	13	32	899.174
#137	FOS	19	10	29	741.207
#138	ZFP36L2	19	6	25	66.563
#139	ZEB1	19	19	38	706.612
#140	TEAD4	19	7	26	526.458
#141	MYCN	19	19	38	784.039
#142	NR2E3	19	10	29	787.674
#143	HOXC10	19	16	35	1680.333
#144	PEG3	19	22	41	8433.684
#145	HOPX	19	13	32	790.622
#146	PHOX2B	19	19	38	5722.565
#147	SIX2	19	17	36	2066.739
#148	SOX9	19	20	39	1248.391
#149	ZNF45	19	12	31	582.205
#150	POU2F2	19	8	27	923.547
#151	MEOX1	19	8	27	702.542
#152	NR2E1	19	24	43	996.232
#153	TSC22D3	19	14	33	815.116
#154	HEY2	19	22	41	5087.733
#155	HOXB1	18	20	38	1968.568
#156	RARA	18	16	34	610.622
#157	ALX4	18	19	37	1013.177
#158	EGR2	18	7	25	199.368
#159	SMAD1	18	20	38	2144.757
#160	HOXA10	18	13	31	2109.884
#161	HOXD4	18	14	32	274.984
#162	ZNF3	18	17	35	1502.835
#163	ARNT2	18	11	29	245.324
#164	TRIM25	18	15	33	1296.118
#165	TBX3	17	15	32	1043.885
#166	ELF4	17	20	37	5916.592
#167	TCEAL1	17	10	27	808.567
#168	MAX	17	16	33	238.392
#169	SPIB	17	7	24	2603.207
#170	LZTS1	17	21	38	849.753
#171	DMRT1	17	14	31	1712.672
#172	SOX21	17	19	36	4006.645
#173	ESRRA	17	16	33	1966.013
#174	ETV1	17	20	37	1781.385
#175	MEF2A	17	20	37	2024.355
#176	ZNF175	16	18	34	1209.069
#177	PGR	16	15	31	496.614
#178	ARNTL	16	12	28	109.486
#179	ZNF236	16	14	30	840.705
#180	NFATC4	16	11	27	179.881
#181	HOXB2	16	11	27	1603.855
#182	NANOG	16	17	33	1452.506
#183	GATA6	16	12	28	1621.734
#184	POU3F4	16	20	36	3321.624
#185	HSF2	16	21	37	1400.218
#186	RUNX2	16	22	38	1573.528
#187	ATF3	16	8	24	1118.748
#188	ZNF434	16	21	37	1679.035
#189	ZNF117	16	25	41	1163.978
#190	PRDM1	16	10	26	209.505
#191	ZNF132	16	21	37	1529.38
#192	LHX6	16	16	32	1396.031
#193	BATF3	16	10	26	1912.209
#194	HOXA4	16	9	25	460.982
#195	TAL1	15	22	37	1509.336
#196	TFAP2B	15	16	31	550.821
#197	SIX3	15	16	31	1007.716
#198	EHF	15	15	30	710.001
#199	KLF15	15	14	29	3675.074
#200	TCF12	15	15	30	750.061
#201	HNF1B	15	26	41	1816.754
#202	MSX2	15	15	30	523.099
#203	ETV5	15	13	28	719.402
#204	REL	15	15	30	1105.779
#205	ETV2	14	20	34	974.379
#206	FOXL2	14	23	37	2933.257
#207	E2F5	14	11	25	470.478
#208	HES1	14	14	28	813.402
#209	RAX	14	10	24	1302.115
#210	ERF	14	17	31	619.52
#211	FOXN2	14	25	39	1912.494
#212	RB1	14	19	33	1040.719
#213	NR1I3	14	21	35	1114.251
#214	HOXB7	14	14	28	1939.326
#215	GABPA	14	17	31	554.569
#216	HOXB6	14	19	33	2106.135
#217	CBL	14	13	27	1128.467
#218	FOSL2	14	17	31	551.845
#219	CBFA2T2	14	11	25	149.556
#220	ZIC1	14	7	21	61.2
#221	NKX2-5	14	20	34	1331.108
#222	HIRA	14	22	36	4269.972
#223	AHR	14	15	29	579.079
#224	NKX3-2	14	8	22	219.78
#225	ALS2CR8	14	19	33	2261.229
#226	SREBF1	14	14	28	574.086
#227	EGR3	14	7	21	362.445
#228	FOXG1	14	20	34	2793.112
#229	PPBPL2	14	21	35	1387.097
#230	WNT5A	14	19	33	811.025
#231	NFX1	13	19	32	941.086
#232	CREB3L1	13	22	35	942.894
#233	MLL	13	19	32	1197.995
#234	HNF4G	13	13	26	927.762
#235	FOXD1	13	17	30	517.135
#236	NEUROD1	13	15	28	819.152
#237	MECOM	13	21	34	1230.069
#238	CUX2	13	21	34	784.32
#239	PAX4	13	21	34	1576.723
#240	TCF4	13	16	29	3674.589
#241	ZNF154	13	20	33	5076.72
#242	ZNF202	13	13	26	758.477
#243	ELK3	13	20	33	1197.522
#244	C11orf9	13	24	37	2057.785
#245	TBR1	13	16	29	838.334
#246	HIC1	13	15	28	1094.245
#247	PRRX2	13	15	28	256.295
#248	SLC26A3	13	15	28	1079.285
#249	TRIM29	13	13	26	324.504
#250	RBPJL	13	18	31	2259.944
#251	IRX4	12	16	28	300.788
#252	PAX5	12	17	29	1455.932
#253	ARNTL2	12	10	22	257.52
#254	FOSL1	12	13	25	817.855
#255	SMAD3	12	21	33	361.35
#256	SOX15	12	17	29	1129.277
#257	PCGF2	12	13	25	290.154
#258	ZNF643	12	14	26	339.341
#259	POU3F3	12	19	31	459.204
#260	BTG2	12	21	33	513.943
#261	NR4A1	12	9	21	965.772
#262	EPAS1	12	17	29	715.264
#263	LHX2	12	14	26	615.455
#264	NR4A2	12	17	29	659.849
#265	ZNF192	12	20	32	1225.571
#266	GLI2	12	20	32	1105.877
#267	PRDM2	12	24	36	958.187
#268	TBX10	12	16	28	1909.533
#269	RARG	12	17	29	853.229
#270	TCF3	12	15	27	446.326
#271	AFF1	12	18	30	989.455
#272	HOXA3	12	22	34	862.115
#273	SRF	12	16	28	332.605
#274	HOXA11	12	20	32	679.82
#275	ZSCAN12	12	14	26	1051.387
#276	TP63	11	18	29	768.328
#277	HOXC13	11	17	28	1237.844
#278	ZIC3	11	15	26	944.251
#279	KLF12	11	21	32	996.557
#280	ELF3	11	16	27	332.444
#281	EN2	11	21	32	1651.245
#282	CEBPD	11	23	34	1676.706
#283	ZFP37	11	19	30	1322.446
#284	PHTF1	11	14	25	614.793
#285	RXRB	11	20	31	650.688
#286	PITX2	11	24	35	2294.957
#287	RCAN1	11	14	25	317.939
#288	RFX3	11	21	32	1837.767
#289	HOXD3	11	19	30	1498.45
#290	HOXC11	11	11	22	357.518
#291	PAX7	11	23	34	1327.608
#292	JUN	11	22	33	889.316
#293	SOX5	11	20	31	863.376
#294	AFF4	11	16	27	854.624
#295	FOXI1	11	24	35	2275.852
#296	SPI1	11	12	23	1488.507
#297	NR5A1	11	19	30	692.754
#298	SMAD5	10	19	29	1743.179
#299	HMX1	10	20	30	1581.42
#300	PTH	10	21	31	1427.168
#301	POU3F1	10	17	27	756.553
#302	MYF6	10	19	29	753.833
#303	KLF4	10	16	26	438.217
#304	VTN	10	23	33	1464.21
#305	BARX1	10	18	28	671.424
#306	HOXD11	10	14	24	1181.065
#307	ZNF80	10	19	29	1548.217
#308	ZNF174	10	17	27	593.929
#309	ZNF165	10	25	35	657.267
#310	SP1	10	14	24	612.593
#311	ASCL2	10	21	31	1339.412
#312	SCRT1	10	15	25	712.016
#313	MLLT10	10	21	31	841.823
#314	PAX6	10	15	25	985.607
#315	ATF5	10	18	28	774.8
#316	TFAP2C	10	12	22	128.237
#317	ZNF81	10	22	32	1461.125
#318	ZNF639	10	11	21	402.19
#319	HOXB3	10	17	27	509.997
#320	MYT1L	10	19	29	1317.135
#321	NFAT5	10	22	32	1350.055
#322	HR	10	20	30	611.373
#323	HEYL	10	17	27	716.621
#324	ESRRG	10	16	26	2321.116
#325	ELK1	10	22	32	1226.05
#326	DLX6	10	17	27	974.049
#327	ONECUT1	10	19	29	1686.025
#328	CITED1	9	16	25	269.627
#329	SIX1	9	23	32	424.577
#330	RFXAP	9	21	30	1078.879
#331	TLX1	9	19	28	748.866
#332	KDM5B	9	20	29	3563.901
#333	TBX6	9	20	29	613.072
#334	PKNOX1	9	23	32	1888.862
#335	NPAS2	9	22	31	712.206
#336	ISL1	9	25	34	1120.125
#337	CREBBP	9	23	32	998.473
#338	RERE	9	13	22	1563.913
#339	ZNF155	9	19	28	801.366
#340	NR0B1	9	32	41	1482.215
#341	NKX3-1	9	16	25	884.17
#342	NKX2-1	9	23	32	2099.793
#343	CEBPE	9	18	27	629.067
#344	HOXB8	9	15	24	593.766
#345	MYT1	9	18	27	675.565
#346	MEF2C	9	24	33	1009.636
#347	LHX1	9	21	30	539.212
#348	FOXD2	9	22	31	878.676
#349	PPARA	9	17	26	635.157
#350	RARB	9	17	26	1080.253
#351	YY1	9	21	30	1723.893
#352	ASCL1	9	17	26	1254.082
#353	FOXH1	9	18	27	715.216
#354	MNX1	9	18	27	499.8
#355	PITX1	9	23	32	8287.233
#356	FOXE3	9	15	24	598.292
#357	HLF	9	16	25	702.77
#358	NR2C2	9	14	23	318.798
#359	TAF1B	9	20	29	1291.352
#360	HOXD9	9	18	27	618.248
#361	TAF13	9	17	26	915.15
#362	IRF6	9	13	22	959.882
#363	MEF2D	9	23	32	1609.908
#364	CRX	9	22	31	2692.793
#365	TBX5	9	21	30	924.061
#366	HOXC5	9	18	27	494.839
#367	ETV4	8	19	27	386.581
#368	SOX2	8	24	32	2312.036
#369	ZFP36L1	8	22	30	1103.24
#370	NEUROG1	8	22	30	1151.386
#371	FOXJ1	8	21	29	932.457
#372	HIF3A	8	19	27	577.228
#373	ZHX3	8	22	30	620.761
#374	ZKSCAN1	8	16	24	875.755
#375	DLX2	8	20	28	430.046
#376	NR1I2	8	20	28	1527.537
#377	BLZF1	8	19	27	1276.198
#378	FOXP3	8	15	23	263.534
#379	ONECUT2	8	23	31	897.601
#380	MYCL1	8	24	32	1063.252
#381	CREBZF	8	19	27	839.825
#382	TFAP4	8	22	30	1068.87
#383	POU4F3	8	25	33	1018.038
#384	POU4F1	8	14	22	593.541
#385	ESRRB	8	21	29	801.486
#386	PROX1	8	20	28	1250.7
#387	MYF5	8	22	30	1275.285
#388	SIM1	8	19	27	1462.096
#389	E2F2	8	15	23	987.695
#390	TEF	8	23	31	1289.647
#391	TLX3	8	25	33	604.622
#392	T	8	26	34	1368.027
#393	ATF6	8	12	20	1152.502
#394	MXD1	8	25	33	795.092
#395	MSC	8	21	29	657.58
#396	RORB	8	16	24	1570.245
#397	IRF5	8	15	23	1155.291
#398	LMX1B	8	16	24	591.631
#399	POU6F2	8	21	29	1125.074
#400	GABPB1	8	22	30	745.401
#401	SIM2	8	18	26	1263.265
#402	PLAG1	7	18	25	245.085
#403	HOXC8	7	21	28	853.824
#404	FOXE1	7	22	29	1018.655
#405	FOXO4	7	23	30	1010.774
#406	VDR	7	22	29	590.682
#407	PDX1	7	25	32	910.518
#408	FOXA2	7	18	25	716.346
#409	TBX2	7	28	35	1010.631
#410	GATA1	7	22	29	932.703
#411	NR2C1	7	25	32	808.169
#412	TCF21	7	18	25	892.685
#413	BRD8	7	21	28	903.458
#414	STRN3	7	18	25	411.945
#415	STAT2	7	24	31	1142.248
#416	POU5F1B	7	20	27	419.877
#417	BACH1	7	16	23	949.955
#418	LEF1	7	21	28	1559.449
#419	POU1F1	7	27	34	918.09
#420	HNF4A	7	19	26	538.53
#421	FOSB	7	4	11	66.47
#422	ARID3A	7	22	29	842.519
#423	IRF4	7	23	30	1238.761
#424	HAND2	7	15	22	639.341
#425	RXRA	7	19	26	734.062
#426	ZNF287	7	18	25	608.047
#427	ZNF134	7	19	26	1452.63
#428	EGR4	7	27	34	908.157
#429	VSX1	7	23	30	993.316
#430	POU6F1	6	16	22	334.326
#431	MLXIPL	6	21	27	2217.652
#432	ST18	6	19	25	518.893
#433	PHOX2A	6	17	23	2342.658
#434	SRY	6	19	25	1322.918
#435	TADA2A	6	24	30	1266.091
#436	CREB5	6	25	31	957.89
#437	MAFK	6	19	25	585.851
#438	TSHZ2	6	18	24	190.043
#439	POU2F3	6	25	31	528.045
#440	GATA4	6	19	25	480.403
#441	SCML1	6	19	25	472.849
#442	TCF7	6	14	20	316.98
#443	ELK4	6	14	20	484.835
#444	WT1	6	19	25	2782.333
#445	NFE2	6	26	32	1168.319
#446	NR1H4	6	25	31	1033.847
#447	PPARD	6	22	28	597.183
#448	SALL1	6	19	25	247.609
#449	ATOH1	6	18	24	381.361
#450	SMAD6	6	18	24	877.792
#451	OVOL1	6	23	29	804.465
#452	OLIG2	6	19	25	1101.938
#453	TSC22D2	6	8	14	197.087
#454	GBX2	6	22	28	2100.94
#455	BNC1	6	23	29	2333.103
#456	MYOG	6	14	20	321.11
#457	HOXB9	6	15	21	319.293
#458	ESR2	6	23	29	680.765
#459	TFDP3	6	23	29	909.75
#460	ERG	6	21	27	325.2
#461	POU3F2	5	26	31	838.61
#462	NR6A1	5	18	23	308.826
#463	ZSCAN2	5	15	20	280.682
#464	NFIX	5	15	20	179.397
#465	THRA	5	22	27	511.458
#466	NR5A2	5	22	27	599.121
#467	IKZF3	5	24	29	1586.541
#468	GSC2	5	24	29	815.454
#469	PKNOX2	5	17	22	238.964
#470	CSRNP3	5	17	22	642.633
#471	GCM1	5	19	24	487.882
#472	ARNT	5	16	21	341.711
#473	HNF1A	5	19	24	472.222
#474	HOXD1	5	19	24	756.379
#475	FOXD3	5	16	21	435.896
#476	RUNX1	5	17	22	347.903
#477	ALX3	5	25	30	418.978
#478	EMX1	4	22	26	390.518
#479	HESX1	4	21	25	2094.758
#480	TCF15	4	15	19	526.316
#481	HOXA2	4	13	17	213.662
#482	DBP	4	16	20	620.167
#483	SATB2	4	23	27	991.586
#484	SNAPC5	4	24	28	701.48
#485	NFATC1	4	20	24	289.368
#486	ZNF157	4	26	30	727.752
#487	FOXB1	4	18	22	324.717
#488	PAX8	4	22	26	421.25
#489	NKX2-8	3	25	28	539.075
#490	FOXC2	3	26	29	296.814
#491	NPAS1	3	18	21	594.847
#492	HOXD13	3	15	18	216.853
#493	TLX2	3	24	27	212.174
#494	SOX30	3	20	23	584.867
#495	PAX3	3	23	26	195.937
#496	CREM	2	25	27	240.944
#497	NR4A3	2	19	21	173.142
#498	ZNF41	2	21	23	91.006
#499	SCAND2	2	26	28	221.519
#500	TBX1	1	21	22	58.491