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Hub Rank	Node	Children	Parents	Degree	Betweenness
#1	NKX3-1	196	0	196	0
#2	POU4F2	141	1	142	3.18
#3	TFCP2L1	123	3	126	27.287
#4	HMGA2	121	5	126	987.976
#5	PHOX2B	111	9	120	2741.228
#6	RFXANK	108	8	116	178.319
#7	EDF1	106	9	115	630.713
#8	E4F1	96	8	104	1096.118
#9	ATF7	94	6	100	1106.177
#10	NPAT	92	5	97	52.882
#11	TSHZ2	91	8	99	636.447
#12	GTF2H3	90	10	100	1949.296
#13	SP4	89	9	98	126.243
#14	ZNF192	85	7	92	81.715
#15	CTBP1	84	6	90	256.374
#16	HNRNPAB	82	10	92	1658.088
#17	HAND1	77	10	87	5862.222
#18	ZNF131	68	12	80	2444.326
#19	CITED2	62	18	80	1047.696
#20	TRIM28	60	11	71	340.466
#21	TBR1	60	8	68	179.585
#22	FOXA1	59	4	63	151.495
#23	TAF7	59	10	69	2072.098
#24	SP3	58	11	69	162.964
#25	KLF15	57	13	70	3893.014
#26	STAT3	57	10	67	261.451
#27	NFATC3	57	14	71	422.695
#28	ATF1	56	16	72	547.563
#29	HCLS1	56	7	63	1419.97
#30	TADA3	55	16	71	395.712
#31	RFX5	54	13	67	188.816
#32	ISL1	53	11	64	797.098
#33	SPDEF	53	4	57	1297.377
#34	MGA	53	18	71	1405.416
#35	HDAC1	52	13	65	1842.024
#36	SREBF1	51	10	61	358.388
#37	ENO1	50	18	68	6435.442
#38	HSF1	50	17	67	272.339
#39	TRIM22	49	6	55	649.044
#40	ADNP2	49	17	66	414.179
#41	NR4A3	49	18	67	3679.404
#42	SLC2A4RG	48	17	65	3746.111
#43	NFYB	48	16	64	605.699
#44	XBP1	48	7	55	473.772
#45	HDAC2	48	20	68	1014.484
#46	TFE3	48	20	68	2018.553
#47	ZNF91	48	16	64	1122.026
#48	NFE2L1	48	11	59	494.252
#49	FUBP1	47	15	62	293.484
#50	E2F3	47	12	59	3105.743
#51	ZNF83	47	18	65	1110.942
#52	FOXF1	46	20	66	802.635
#53	NFKB2	46	7	53	121.167
#54	TCF3	46	17	63	492.741
#55	GATA3	45	7	52	445.066
#56	ELF1	45	12	57	615.367
#57	BUD31	45	10	55	563.927
#58	CNOT8	44	16	60	320.141
#59	IRX5	44	14	58	4199.336
#60	ZNF217	44	23	67	2780.373
#61	BHLHE40	44	10	54	2285.178
#62	ZGPAT	43	12	55	512.895
#63	NFIC	43	17	60	1066.159
#64	SOX4	43	20	63	4186.596
#65	YBX1	43	11	54	811.778
#66	ESR1	43	11	54	933.418
#67	MZF1	42	17	59	571.025
#68	HMGB2	42	9	51	179.188
#69	FLI1	41	2	43	86.134
#70	NFE2	41	10	51	3544.781
#71	KLF2	41	13	54	2574.766
#72	FOXC1	41	8	49	190.451
#73	NFYC	40	13	53	285.49
#74	REST	40	14	54	2629.409
#75	NR3C1	40	18	58	1041.153
#76	MAX	40	11	51	600.93
#77	HOXA11	40	17	57	790.81
#78	EPAS1	39	17	56	784.92
#79	E2F6	39	16	55	665.505
#80	SPIB	39	17	56	1929.481
#81	RFX3	39	13	52	179.241
#82	REXO4	38	17	55	891.127
#83	ATF2	38	14	52	1585.146
#84	SUPT6H	37	15	52	326.228
#85	IRF9	37	12	49	1107.811
#86	ZIC3	37	17	54	810.98
#87	PBX1	36	23	59	591.047
#88	MBD1	36	24	60	2278.267
#89	CEBPB	35	18	53	2232.912
#90	PKNOX1	34	13	47	716.249
#91	JUND	33	19	52	389.166
#92	TCFL5	33	17	50	391.581
#93	TAL1	33	11	44	1019.018
#94	ZXDC	33	17	50	254.544
#95	SRF	33	22	55	3706.329
#96	BCL6	32	17	49	269.748
#97	HIRA	32	15	47	491.736
#98	SOX10	32	12	44	603.275
#99	HOXD4	32	25	57	2834.327
#100	EN1	31	8	39	86.253
#101	ZNF277	31	21	52	703.338
#102	FOXO3	31	23	54	2603.794
#103	ZNF394	31	20	51	1374.373
#104	HNF4A	31	25	56	596.051
#105	JUN	31	17	48	839.404
#106	GLI2	31	13	44	2085.403
#107	PLSCR1	31	18	49	1322.734
#108	AR	30	8	38	97.877
#109	MAFB	30	20	50	3055.272
#110	ZNF165	30	18	48	477.848
#111	RUNX2	30	15	45	1551.728
#112	HOXD11	30	18	48	3291.297
#113	BLZF1	29	20	49	889.466
#114	AHR	29	23	52	684.4
#115	GABPA	29	25	54	951.043
#116	FOXO1	28	11	39	1483.712
#117	FOXM1	27	10	37	332.186
#118	PPBPL2	27	17	44	124.933
#119	E2F1	27	22	49	1457.306
#120	RARA	26	19	45	1590.831
#121	MEF2C	26	11	37	506.078
#122	HSF2	26	18	44	4187.783
#123	POU3F4	26	21	47	1976.865
#124	BNC1	26	15	41	778.395
#125	HMGA1	26	14	40	511.483
#126	MSRB2	26	16	42	1524.217
#127	HNF1B	26	17	43	335.971
#128	RUNX3	26	8	34	147.475
#129	ARNTL	26	17	43	362.039
#130	ZBTB48	25	16	41	131.772
#131	TAF12	25	18	43	622.782
#132	BCL11B	25	5	30	60.423
#133	YEATS4	25	21	46	742.667
#134	TBX6	25	24	49	574.342
#135	SATB1	25	19	44	944.794
#136	SP140	25	9	34	6296.972
#137	POU3F1	24	19	43	4094.5
#138	MYBL2	24	9	33	158.879
#139	ZNF140	24	23	47	993.918
#140	CSDA	24	19	43	1490.258
#141	SOX21	24	17	41	2112.365
#142	HINFP	24	23	47	414.364
#143	GTF2I	24	9	33	248.07
#144	SNAI2	24	16	40	1003.603
#145	ELK3	23	18	41	373.441
#146	STAT1	23	14	37	512.702
#147	KLF9	23	20	43	1375.748
#148	RXRA	23	26	49	624.358
#149	SMAD1	23	22	45	7795.82
#150	SOX17	23	23	46	2793.169
#151	SOX5	23	23	46	4606.545
#152	SIM2	23	21	44	685.981
#153	HSF4	22	23	45	3705.01
#154	AEBP1	22	16	38	612.32
#155	NEUROG1	22	23	45	738.264
#156	PHOX2A	22	21	43	982.902
#157	SMAD3	22	27	49	902.263
#158	USF2	22	20	42	2096.396
#159	FOXN3	22	21	43	639.244
#160	ZNF45	22	23	45	1423.731
#161	ELF5	21	12	33	487.259
#162	PEG3	21	34	55	2523.044
#163	E2F8	21	18	39	820.543
#164	LMO4	21	18	39	2959.633
#165	NR2F6	21	18	39	499.466
#166	MYC	21	21	42	797.5
#167	NR2F2	21	21	42	1543.502
#168	TBX3	20	14	34	1005.482
#169	ZNF446	20	14	34	328.072
#170	ZFP36L2	20	20	40	487.8
#171	MTA2	20	23	43	758.241
#172	KLF6	20	25	45	6238.342
#173	ZFHX3	20	22	42	481.374
#174	TFEC	20	14	34	418.611
#175	CDKN2A	20	11	31	637.375
#176	HOXD9	20	24	44	1169.999
#177	TP63	19	23	42	3806.732
#178	SMAD6	19	26	45	1302.041
#179	MLLT10	19	21	40	503.474
#180	MAF	19	21	40	2860.715
#181	ESR2	19	23	42	1693.051
#182	TFEB	19	14	33	799.097
#183	LHX6	19	22	41	610.484
#184	NR1H4	19	21	40	1120.436
#185	ALX3	19	24	43	3908.552
#186	HMG20B	19	14	33	2124.48
#187	TFAM	19	18	37	683.661
#188	FOXE1	18	26	44	411.602
#189	NR5A1	18	17	35	902.917
#190	LHX2	18	29	47	2178.213
#191	TRPS1	18	18	36	2530.084
#192	ATF3	18	15	33	2664.1
#193	SNAPC4	18	20	38	785.508
#194	NR2E1	18	22	40	4337.092
#195	PROX1	17	19	36	1274.967
#196	STRN3	17	21	38	393.318
#197	HOXB1	17	23	40	1862.023
#198	MAFF	17	20	37	941.89
#199	PDX1	17	18	35	509.789
#200	BRD8	17	22	39	3163.966
#201	TCF4	17	24	41	397.95
#202	POU1F1	17	28	45	3144.933
#203	STAT2	17	27	44	3158.047
#204	NFYA	17	23	40	464.131
#205	TP73	16	25	41	1103.4
#206	GAS7	16	24	40	423.896
#207	HOXA5	16	21	37	362.754
#208	FOXL2	16	23	39	2488.819
#209	ZNF444	16	16	32	178.351
#210	PCGF2	16	20	36	2665.542
#211	POU2F2	16	23	39	1208.812
#212	EMX1	16	16	32	868.74
#213	RUNX1	16	26	42	2417.182
#214	MSX2	16	23	39	310.647
#215	NR1I3	16	21	37	1220.7
#216	MEOX1	15	19	34	989.447
#217	FOXD2	15	18	33	5212.786
#218	CSRNP3	15	18	33	443.266
#219	ZNF154	15	21	36	1010.956
#220	MNX1	15	22	37	1646.871
#221	HIF3A	15	20	35	2090.275
#222	TBX19	15	26	41	1182.498
#223	ATF6	15	16	31	356.474
#224	NFAT5	15	17	32	474.207
#225	TCF7L2	15	15	30	346.015
#226	MLXIPL	15	20	35	1395.131
#227	TBX10	15	21	36	1252.823
#228	CEBPE	15	23	38	2141.768
#229	FOXA2	15	21	36	925.566
#230	ECSIT	15	19	34	199.629
#231	NR2C2	15	33	48	2343.045
#232	HOXA9	15	22	37	1292.322
#233	ZNF3	14	20	34	636.467
#234	CREB3L1	14	14	28	537.537
#235	PHTF1	14	23	37	1629.949
#236	HOPX	14	16	30	479.936
#237	NKX3-2	14	30	44	2397.262
#238	NR2E3	14	21	35	532.416
#239	ZNF174	14	27	41	734.802
#240	TBX2	14	27	41	3899.828
#241	TLX2	14	30	44	3769.996
#242	BHLHE41	14	25	39	685.145
#243	TFDP3	14	23	37	468.346
#244	ZEB2	14	16	30	324.022
#245	ZHX2	14	18	32	1008.188
#246	CTNNB1	14	14	28	99.502
#247	SIX2	14	25	39	1763.405
#248	LHX1	14	24	38	878.548
#249	ZFP36L1	14	27	41	3177.372
#250	HOXA3	14	19	33	2322.155
#251	SOX13	14	19	33	641.743
#252	MYT1	14	21	35	1689.504
#253	GATA2	13	16	29	1072.887
#254	NR1I2	13	26	39	1869.722
#255	ETS1	13	22	35	1213.948
#256	HOXD13	13	28	41	1747.875
#257	GATA1	13	23	36	1792.699
#258	HOXB2	13	16	29	571.284
#259	MEF2D	13	21	34	635.714
#260	ESRRG	13	17	30	722.98
#261	BTG2	13	20	33	607.868
#262	PPARD	13	20	33	1405.136
#263	PPARA	13	29	42	3569.741
#264	HOXB9	13	25	38	9163.937
#265	NKX2-5	13	20	33	475.011
#266	ONECUT1	13	22	35	478.768
#267	KLF12	13	29	42	3269.098
#268	HOXC8	13	28	41	1644.451
#269	NFX1	13	31	44	901.651
#270	VTN	13	19	32	438.708
#271	KLF5	13	27	40	565.9
#272	VDR	13	20	33	1508.049
#273	IKZF1	13	23	36	3701.702
#274	HR	13	19	32	482.203
#275	HNF1A	13	24	37	767.612
#276	WNT5A	12	30	42	603.849
#277	FOSB	12	13	25	1075.877
#278	HOXA7	12	21	33	1004.909
#279	NFATC1	12	20	32	1389.412
#280	ELF4	12	24	36	5296.008
#281	MYT1L	12	26	38	1325.682
#282	ZFPM2	12	24	36	2554.493
#283	ONECUT2	12	25	37	1750.777
#284	HOXB6	12	19	31	531.857
#285	POU6F1	12	19	31	1512.812
#286	E2F5	12	21	33	524.348
#287	MEF2A	12	27	39	924.533
#288	EGR1	12	17	29	1400.35
#289	PKNOX2	12	18	30	674.992
#290	GATA4	11	23	34	983.51
#291	RARG	11	18	29	5888.211
#292	VSX1	11	18	29	1089.517
#293	SOX11	11	15	26	276.466
#294	ZNF287	11	24	35	871.498
#295	OLIG2	11	19	30	3167.153
#296	CEBPD	11	18	29	141.674
#297	FOXC2	11	14	25	341.018
#298	FOS	11	17	28	367.536
#299	DBP	11	27	38	556.986
#300	E2F4	11	19	30	389.423
#301	PRDM1	11	23	34	2469.609
#302	EGR3	11	19	30	2210.513
#303	TEAD4	11	17	28	729.256
#304	TSC22D3	11	31	42	484.059
#305	TWIST1	10	28	38	1165.365
#306	MEOX2	10	24	34	2020.027
#307	IKZF3	10	21	31	556.306
#308	SOX9	10	24	34	2187.711
#309	TLX3	10	30	40	1821.98
#310	PRDM2	10	24	34	808.365
#311	MLL	10	28	38	1961.79
#312	PGR	10	20	30	564.071
#313	ARNTL2	10	17	27	2135.35
#314	EHF	10	24	34	506.824
#315	NEUROD1	10	25	35	471.21
#316	MEIS2	10	25	35	568.758
#317	SPI1	10	22	32	396.524
#318	ATOH1	10	22	32	1059.696
#319	ETV5	10	21	31	2060.129
#320	KLF4	10	28	38	1151.036
#321	TBX5	10	24	34	1584.619
#322	NANOG	10	26	36	1731.05
#323	TCF7	10	16	26	387.598
#324	POU5F1B	10	20	30	344.472
#325	ATF5	10	22	32	573.402
#326	ASCL2	10	30	40	3542.701
#327	PITX1	10	26	36	650.044
#328	FOXH1	9	17	26	368.676
#329	NR4A1	9	25	34	805.667
#330	ZNF202	9	32	41	2326.628
#331	LEF1	9	21	30	356.769
#332	TRIM25	9	25	34	567.821
#333	HESX1	9	23	32	1051.428
#334	SIX3	9	12	21	79.148
#335	HOXB7	9	24	33	1797.146
#336	FOXO4	9	20	29	1308.05
#337	NR3C2	9	19	28	797.649
#338	HOXC10	9	14	23	162.854
#339	NFIB	9	21	30	915.686
#340	TEF	9	20	29	362.332
#341	NKX2-1	9	21	30	439.504
#342	RBPJL	9	24	33	1138.781
#343	HEY1	9	24	33	2837.234
#344	KDM5B	9	27	36	408.351
#345	SALL1	9	28	37	1708.943
#346	MMP14	9	22	31	2735.239
#347	IRF7	8	17	25	480.975
#348	ETV2	8	23	31	1256.956
#349	HOXB13	8	25	33	632.64
#350	PHF1	8	21	29	438.202
#351	ARID3A	8	23	31	1970.986
#352	FOSL2	8	26	34	394.975
#353	PAX6	8	20	28	273.701
#354	ZIC1	8	13	21	214.578
#355	TADA2A	8	21	29	317.15
#356	HOXA1	8	21	29	509.108
#357	ZNF155	8	29	37	273.194
#358	NRL	8	25	33	871.188
#359	FOXI1	8	25	33	681.839
#360	TCF12	8	18	26	181.96
#361	EGR2	8	22	30	470.676
#362	PAX4	8	24	32	356.519
#363	ETV1	8	29	37	698.989
#364	CITED1	8	27	35	2506.165
#365	PRRX2	8	26	34	345.227
#366	ZHX3	8	30	38	2139.203
#367	RXRB	8	22	30	401.394
#368	POU3F3	8	27	35	701.282
#369	TRIM29	8	16	24	441.098
#370	ZNF643	8	31	39	841.281
#371	OVOL1	7	23	30	829.154
#372	ZSCAN18	7	18	25	402.765
#373	ZEB1	7	22	29	710.888
#374	RCAN1	7	26	33	1900.783
#375	ELK1	7	23	30	242.06
#376	C2orf3	7	28	35	657.47
#377	ZNF135	7	26	33	1011.899
#378	SOX2	7	26	33	1069.188
#379	ZNF134	7	27	34	3226.287
#380	SATB2	7	28	35	2217.431
#381	TFAP2A	7	28	35	1617.364
#382	BATF3	7	27	34	436.127
#383	SCAND2	7	31	38	402.801
#384	RFXAP	7	24	31	1319.801
#385	NR0B1	7	30	37	1644.711
#386	HOXC13	7	23	30	457.288
#387	NR2F1	7	35	42	1167.359
#388	HOXB3	7	22	29	190.981
#389	TFAP2B	7	25	32	328.481
#390	RB1	7	30	37	658.248
#391	POU2F3	7	28	35	589.666
#392	NFIX	7	32	39	725.879
#393	NR2C1	7	28	35	650.318
#394	ZNF41	7	28	35	2009.172
#395	ZNF238	6	31	37	896.745
#396	ARNT	6	27	33	549.65
#397	SRY	6	26	32	422.882
#398	TFAP2C	6	28	34	154.123
#399	MSX1	6	24	30	665.751
#400	MSC	6	25	31	509.544
#401	SIX1	6	27	33	238.06
#402	GATA6	6	24	30	749.751
#403	TP53	6	23	29	317.321
#404	SNAPC5	6	27	33	857.343
#405	SCML1	6	22	28	501.371
#406	ZNF80	6	27	33	657.391
#407	PAX8	6	33	39	1845.927
#408	SOX15	6	24	30	388.29
#409	SIM1	6	26	32	638.402
#410	CREBBP	6	25	31	464.811
#411	MYF6	6	22	28	126.891
#412	CBFA2T2	6	31	37	790.904
#413	ZNF236	6	34	40	1229.756
#414	FOXJ1	6	24	30	420.134
#415	DLX6	6	17	23	818.353
#416	E2F2	6	26	32	830.12
#417	SOX30	6	27	33	1230.007
#418	MXD1	6	22	28	585.226
#419	ZNF157	6	28	34	796.793
#420	HOXD1	5	18	23	453.376
#421	ZNF81	5	26	31	928.931
#422	POU4F3	5	28	33	2141.801
#423	NR6A1	5	21	26	75.752
#424	TSC22D2	5	28	33	386.509
#425	TCF21	5	24	29	375.321
#426	ZFP37	5	28	33	366.902
#427	BARX1	5	28	33	588.786
#428	EGR4	5	23	28	237.043
#429	CREB5	5	26	31	1200.145
#430	GABPB1	5	29	34	1089.745
#431	SCRT1	5	25	30	1246.236
#432	FOXG1	5	28	33	199.764
#433	TCF15	5	25	30	392.737
#434	TAF1B	5	30	35	1247.854
#435	HOXA2	5	28	33	1092.927
#436	CUX2	5	28	33	1175.093
#437	PTH	5	28	33	1085.908
#438	HEY2	5	29	34	950.7
#439	SOX18	5	27	32	484.161
#440	TFDP2	5	23	28	579.957
#441	RUNX1T1	5	26	31	718.275
#442	IRX4	5	25	30	1328.284
#443	ERF	5	21	26	864.414
#444	FOXP3	5	22	27	1251.178
#445	MYCN	5	37	42	745.906
#446	ZNF323	5	31	36	745.629
#447	PLAG1	5	25	30	426.436
#448	PAX5	5	21	26	412.464
#449	WT1	5	30	35	715.278
#450	NR4A2	5	21	26	140.775
#451	ASCL1	5	36	41	6263.261
#452	NPAS1	4	25	29	1289.433
#453	ARNT2	4	23	27	286.616
#454	YY1	4	24	28	799.992
#455	NPAS2	4	31	35	384.261
#456	RERE	4	35	39	564.498
#457	TAF13	4	31	35	495.504
#458	MECOM	4	25	29	2213.351
#459	ZNF167	4	33	37	971.254
#460	GCM1	4	20	24	336.812
#461	IRF4	4	34	38	732.148
#462	NR5A2	4	34	38	536.257
#463	PITX2	4	26	30	396.576
#464	MYF5	4	39	43	1284.112
#465	HOXD3	4	37	41	234.539
#466	HNF4G	4	24	28	780.425
#467	LZTS1	4	28	32	390.396
#468	ST18	4	35	39	984.137
#469	ELK4	4	33	37	516.744
#470	FOSL1	4	29	33	679.701
#471	SP1	4	21	25	601.461
#472	FOXB1	4	26	30	765.203
#473	NFATC4	4	28	32	516.062
#474	ZNF639	4	30	34	609.039
#475	TBX1	4	30	34	2033.227
#476	POU6F2	4	19	23	71.601
#477	ERG	3	24	27	235.073
#478	FOXD1	3	22	25	571.674
#479	CREM	3	23	26	263.81
#480	CREBZF	3	24	27	130.117
#481	THRA	3	24	27	172.972
#482	ZNF117	3	23	26	356.591
#483	GBX2	3	30	33	585.705
#484	PPARG	3	35	38	1089.968
#485	SLC26A3	3	26	29	194.209
#486	POU4F1	3	31	34	247.429
#487	DLX2	3	27	30	289.983
#488	C11orf9	2	27	29	227.157
#489	FOXD3	2	31	33	385.082
#490	HLF	2	29	31	435.072
#491	GSC2	2	30	32	158.057
#492	DMRT1	2	27	29	166.145
#493	HOXA10	2	23	25	693.357
#494	MAFK	1	32	33	97.262
#495	ETV4	1	28	29	105.447
#496	RARB	1	17	18	810.092
#497	PAX3	1	30	31	113.7
#498	EN2	1	27	28	154.552
#499	POU3F2	1	22	23	452.343
#500	ZNF175	0	31	31	0