Hub Rank	Node	Children	Parents	Degree	Betweenness
#1	HOXB5	141	8	149	1229.49
#2	PAX8	140	6	146	320.385
#3	FOXJ2	138	15	153	392.865
#4	E2F4	135	10	145	79.354
#5	STAT4	134	10	144	353.204
#6	ATF7	131	15	146	488.38
#7	MMP14	127	3	130	38.09
#8	EDF1	127	17	144	672.823
#9	E2F1	124	20	144	417.19
#10	HSF1	122	5	127	567.974
#11	PRRX1	121	1	122	3.859
#12	DDIT3	120	13	133	200.329
#13	SCAND1	120	15	135	756.97
#14	RUNX1T1	116	13	129	1078.827
#15	PHF1	114	16	130	638.554
#16	ZNF219	110	7	117	2168.881
#17	RARB	107	17	124	220.911
#18	GATA2	105	16	121	292.696
#19	ELK1	100	7	107	157.91
#20	SOX2	100	11	111	850.829
#21	PA2G4	98	21	119	1551.41
#22	FOXF2	97	10	107	172.274
#23	PRDM2	97	17	114	1757.289
#24	SOX15	97	27	124	448.244
#25	TCF7	97	24	121	446.918
#26	ETV1	96	21	117	516.534
#27	CCRN4L	92	24	116	456.867
#28	FOXN3	92	20	112	386.659
#29	MYT1	91	22	113	538.973
#30	LHX3	91	20	111	281.315
#31	POU4F2	90	18	108	502.864
#32	ADNP	90	6	96	166.547
#33	THRA	89	22	111	739.995
#34	KLF1	88	30	118	2003.726
#35	NEUROD2	88	19	107	380.951
#36	REL	87	20	107	260.566
#37	ZNF238	86	5	91	128.347
#38	TCF7L2	83	15	98	965.725
#39	NFE2L1	83	28	111	528.22
#40	KLF15	82	21	103	464.019
#41	CNOT8	81	10	91	318.356
#42	ZNF207	79	27	106	1187.197
#43	YBX1	79	17	96	281.083
#44	DLX2	78	18	96	2868.025
#45	FOXF1	78	18	96	492.555
#46	PTTG1	78	23	101	691.071
#47	HAND1	77	25	102	1967.096
#48	KLF7	74	21	95	1207.544
#49	E4F1	73	17	90	3268.697
#50	NFE2L2	73	10	83	765.722
#51	ESR1	72	26	98	1118.293
#52	SP4	72	25	97	649.053
#53	HEY1	72	23	95	419.614
#54	SCMH1	71	14	85	318.443
#55	ZNF444	71	24	95	758.76
#56	PKNOX2	70	27	97	462.518
#57	ZNF197	70	31	101	592.715
#58	CTCF	70	45	115	1754.053
#59	ZNF277	69	23	92	410.661
#60	GTF2H3	69	25	94	1959.769
#61	FBXW7	68	17	85	378.129
#62	HNRNPAB	68	22	90	1153.911
#63	HOXC11	67	23	90	1643.224
#64	SPIB	66	31	97	1808.445
#65	ZNF202	66	22	88	438.953
#66	TGIF1	66	9	75	94.78
#67	ZNF236	65	31	96	389.748
#68	TAF4B	65	32	97	646.436
#69	THRB	64	22	86	1205.076
#70	NR5A2	64	22	86	2731.016
#71	IRF4	64	30	94	1616.012
#72	PCGF2	64	22	86	1689.901
#73	JUND	63	28	91	627.236
#74	ZFHX4	63	34	97	844.925
#75	RFX5	63	35	98	713.824
#76	TBP	63	17	80	750.43
#77	MAX	63	31	94	1009.333
#78	SMAD2	62	15	77	684.805
#79	CUX1	62	29	91	2188.042
#80	FLI1	62	27	89	604.43
#81	ELF2	62	31	93	626.023
#82	NFYA	61	26	87	204.168
#83	ZBTB17	61	27	88	2172.526
#84	NFYC	60	12	72	2478.129
#85	SALL2	60	25	85	442.638
#86	HMGB2	60	12	72	143.816
#87	DLX4	60	32	92	958.267
#88	IRF3	60	21	81	821.919
#89	CSDA	58	30	88	796.882
#90	PBX1	57	18	75	238.84
#91	TGIF2	56	27	83	1554.981
#92	LZTR1	55	38	93	1285.002
#93	NPAT	55	28	83	1218.91
#94	EHF	55	15	70	128.419
#95	MLL	55	28	83	1162.979
#96	PHOX2B	53	32	85	509.598
#97	HCLS1	53	33	86	1562.561
#98	MYOD1	53	15	68	331.074
#99	POU4F1	52	24	76	228.016
#100	ZNF140	52	36	88	2169.634
#101	KDM5A	52	22	74	483.065
#102	MTF1	51	13	64	1235.208
#103	ZBTB48	51	21	72	1430.962
#104	RERE	50	36	86	575.943
#105	FOXA1	50	39	89	918.198
#106	TCF4	50	31	81	1260.034
#107	SNAPC4	50	27	77	668.608
#108	ECSIT	49	21	70	558.313
#109	RXRG	48	35	83	1071.729
#110	TAF7	48	23	71	435.911
#111	ZNF93	47	27	74	155.129
#112	TBX6	47	26	73	955.121
#113	MEF2A	47	22	69	231.34
#114	TBX2	47	25	72	1457.504
#115	ELK3	46	16	62	216.202
#116	CBFA2T3	46	36	82	2455.063
#117	PURA	46	18	64	229.784
#118	SOX4	46	26	72	556.789
#119	HIF1A	45	27	72	1713.858
#120	MNT	45	35	80	3373.177
#121	TLX3	45	26	71	435.103
#122	CREBL2	45	20	65	948.27
#123	NR1H4	45	35	80	425.765
#124	NFATC3	45	30	75	856.871
#125	PHTF1	45	18	63	364.686
#126	ETV6	44	30	74	1450.689
#127	GATAD2A	44	43	87	1163.958
#128	TCF25	44	27	71	536.076
#129	TRIM25	44	22	66	1328.816
#130	HMGA2	44	37	81	907.66
#131	MZF1	44	39	83	594.553
#132	POU3F1	44	34	78	704.981
#133	NR1H2	43	35	78	1909.132
#134	PLAGL2	43	37	80	732.247
#135	NFAT5	43	44	87	1763.213
#136	CBFB	43	28	71	1071.019
#137	FOXD1	43	10	53	207.655
#138	ELF1	42	22	64	1288.955
#139	ZNF434	42	38	80	1591.25
#140	TRIM22	42	12	54	695.3
#141	TCF12	42	28	70	1038.163
#142	MLLT10	42	35	77	933.959
#143	ZNF192	42	29	71	294.058
#144	TFCP2L1	41	36	77	507.012
#145	CITED2	41	25	66	728.512
#146	RB1	41	10	51	510.554
#147	CBFA2T2	41	34	75	2150.325
#148	PROX1	40	25	65	331.006
#149	KLF9	40	35	75	622.609
#150	CSRNP2	40	36	76	1298.085
#151	HMX1	40	31	71	489.453
#152	TCF3	40	42	82	579.197
#153	GAS7	40	20	60	236.56
#154	IRF2	40	22	62	693.133
#155	UBN1	39	31	70	1032.599
#156	MEIS2	39	27	66	658.391
#157	E2F3	39	30	69	901.83
#158	BTAF1	39	29	68	538.68
#159	TFDP1	39	21	60	1516.721
#160	HOXA6	38	34	72	495.552
#161	SIX1	38	33	71	2217.532
#162	TCF20	38	28	66	800.357
#163	LASS2	38	28	66	229.365
#164	CNBP	37	30	67	534.452
#165	IKZF1	37	40	77	1718.061
#166	SPEN	37	14	51	252.164
#167	PEG3	37	28	65	416.513
#168	ZNF133	37	29	66	871.626
#169	TRIM28	37	36	73	654.856
#170	MYNN	36	25	61	716.428
#171	HOXD1	36	36	72	406.822
#172	RCOR1	36	30	66	1901.335
#173	NFYB	36	44	80	1455.441
#174	TRPS1	36	39	75	892.724
#175	FOXJ3	36	29	65	560.374
#176	TFEB	36	23	59	849.268
#177	ZSCAN18	35	34	69	1964.683
#178	NFIB	35	19	54	1891.27
#179	FOXH1	35	39	74	1902.178
#180	TBX21	35	42	77	738.128
#181	STAT3	34	30	64	554.108
#182	SMAD1	34	36	70	594.958
#183	TEAD3	34	38	72	3305.563
#184	FOXE1	34	29	63	362.331
#185	ZGPAT	34	27	61	942.382
#186	PLSCR1	34	14	48	1036.961
#187	SMAD4	33	16	49	335.119
#188	AHR	33	24	57	876.249
#189	BHLHE40	33	23	56	588.89
#190	PLAG1	33	28	61	1698.468
#191	DRAP1	33	34	67	606.952
#192	CREM	33	36	69	2764.442
#193	HNF1B	33	47	80	480.174
#194	ZNF148	33	23	56	326.328
#195	MEIS1	32	36	68	852.904
#196	ZKSCAN3	32	36	68	353.59
#197	ELF4	32	34	66	739.104
#198	IRF5	32	41	73	1319.285
#199	RNF4	32	47	79	832.392
#200	HCFC1	32	35	67	673.444
#201	GLI2	32	35	67	908.035
#202	MEF2C	32	34	66	1096.996
#203	RBCK1	32	41	73	618.687
#204	SP3	32	23	55	292.849
#205	HOXD11	31	40	71	1011.868
#206	ZNF446	31	42	73	845.084
#207	BCL11B	31	36	67	2072.811
#208	TFE3	31	40	71	879.02
#209	TARDBP	31	35	66	337.087
#210	RFXANK	30	45	75	1036.689
#211	GLI3	30	31	61	594.654
#212	NOLC1	30	31	61	2473.596
#213	MAFB	30	24	54	280.416
#214	STAT5B	30	42	72	1799.866
#215	SLC30A9	30	25	55	497.022
#216	ZNF274	29	37	66	1923.876
#217	ZNF217	29	17	46	181.305
#218	SUPT6H	29	39	68	686.289
#219	HDAC1	29	44	73	487.058
#220	REXO4	29	37	66	2646.808
#221	FOXN2	29	38	67	604.996
#222	C2orf3	29	31	60	902.829
#223	MTA1	29	38	67	468.992
#224	GATA3	29	37	66	1366.848
#225	NOTCH1	28	30	58	868.154
#226	ZNF3	28	38	66	1164.184
#227	ZXDC	28	32	60	788.234
#228	ZNF189	28	24	52	821.088
#229	POU2F1	28	39	67	2311.315
#230	KLF4	28	30	58	1091.813
#231	NR1I2	28	41	69	1176.786
#232	VTN	28	36	64	1793.338
#233	TSC22D4	28	35	63	944.365
#234	ZNF85	27	52	79	2016.566
#235	SRF	27	39	66	2112.46
#236	TADA2A	27	48	75	3437.685
#237	ZKSCAN1	27	45	72	3142.146
#238	ZNF263	27	48	75	2614.73
#239	T	27	22	49	371.587
#240	HMG20A	27	34	61	301.57
#241	AFF1	27	30	57	515.262
#242	HOXB9	26	43	69	963.614
#243	CREBBP	26	38	64	587.346
#244	DMTF1	26	31	57	428.169
#245	HOXC4	26	38	64	638.094
#246	ESRRG	26	33	59	749.195
#247	HLF	26	26	52	1090.606
#248	ZNF175	26	38	64	1358.127
#249	FOSB	25	6	31	613.146
#250	ATF6B	25	41	66	3455.456
#251	ZKSCAN4	25	39	64	582.648
#252	PITX1	25	51	76	1400.694
#253	SUPT4H1	25	29	54	769.843
#254	ZNF500	25	49	74	907.713
#255	YY1	25	25	50	329.477
#256	CEBPB	25	48	73	1235.498
#257	NR1H3	25	43	68	1069.628
#258	USF2	25	44	69	842.199
#259	NFKB1	25	45	70	754.493
#260	ATF5	25	46	71	753.53
#261	NR4A2	24	10	34	417.256
#262	HSF2	24	33	57	508.909
#263	CIR1	24	35	59	655.274
#264	HIF3A	24	37	61	829.557
#265	ZFP36L1	24	35	59	1016.452
#266	IRF9	24	49	73	2280.911
#267	EGR3	23	17	40	1219.548
#268	SIX2	23	40	63	1332.252
#269	KDM5B	23	27	50	571.91
#270	IRX5	23	35	58	456.172
#271	ETV7	23	45	68	836.576
#272	ZNF117	23	45	68	854.774
#273	STAT2	23	47	70	1535.378
#274	ZNF193	23	44	67	1023.337
#275	E2F6	23	36	59	668.615
#276	KLF11	22	36	58	387.505
#277	TCF7L1	22	48	70	1547.768
#278	MBD1	22	38	60	910.694
#279	ZFHX3	22	35	57	1473.28
#280	RXRA	22	38	60	741.171
#281	ATF3	22	4	26	48.518
#282	IKZF4	22	43	65	1301.915
#283	NCOR1	22	41	63	1883.957
#284	GABPB1	22	38	60	556.388
#285	FOXM1	22	32	54	1205.299
#286	MAFF	22	22	44	1174.102
#287	LZTS1	22	44	66	1410.867
#288	PKNOX1	22	42	64	1157.443
#289	RUNX1	22	53	75	1050.292
#290	BACH2	22	28	50	661.287
#291	TBX5	21	36	57	465.794
#292	PAX5	21	36	57	665.789
#293	SLC2A4RG	21	43	64	462.739
#294	HOXC10	21	48	69	539.728
#295	PBX3	21	48	69	1237.434
#296	RUNX2	21	37	58	573.141
#297	MLX	21	47	68	1167.672
#298	SIM2	21	38	59	484.461
#299	NR2F6	21	40	61	1168.674
#300	CREBZF	21	34	55	669.806
#301	TBX10	20	39	59	447.959
#302	VDR	20	50	70	782
#303	PAX3	20	33	53	542.741
#304	ETS2	20	50	70	677.095
#305	GATA1	20	38	58	859.971
#306	KLF6	20	20	40	739.5
#307	ZSCAN5A	20	40	60	883.595
#308	NFKB2	19	36	55	314.063
#309	SNAI2	19	37	56	607.54
#310	ZSCAN12	19	39	58	260.021
#311	SMAD3	19	48	67	1554.169
#312	SCML2	19	41	60	693.159
#313	SNAPC2	19	45	64	1090.281
#314	BHLHE41	19	25	44	336.301
#315	XBP1	18	29	47	260.608
#316	MSL3	18	40	58	688.445
#317	IRF8	18	48	66	2762.712
#318	SOX21	18	50	68	1530.986
#319	EGR2	18	5	23	41.071
#320	CEBPA	18	48	66	500.735
#321	RBPJ	18	40	58	1209.213
#322	ZNF24	18	46	64	776.742
#323	TFAM	18	38	56	2265.917
#324	HMG20B	18	42	60	772.456
#325	NFIL3	18	40	58	876.269
#326	TSC22D1	18	42	60	1370.529
#327	STAT5A	17	43	60	1214.109
#328	HOXA4	17	53	70	982.378
#329	JUN	17	7	24	200.751
#330	RORC	17	50	67	1036.404
#331	FOXC1	17	56	73	3971.854
#332	SOX13	17	38	55	291.228
#333	ZHX2	17	35	52	450.305
#334	ZNF33B	17	49	66	1293.278
#335	HOXA11	17	44	61	386.791
#336	BTG2	17	8	25	151.083
#337	MAFG	17	45	62	1165.048
#338	ZFP36L2	17	26	43	972.569
#339	NFIC	17	39	56	829.849
#340	BATF	17	49	66	1747.211
#341	ZNF232	17	45	62	552.447
#342	HOXB7	17	36	53	650.809
#343	KLF3	17	33	50	1244.412
#344	ATF2	17	51	68	982.319
#345	TAF5L	16	47	63	802.245
#346	HNRNPK	16	38	54	339.838
#347	ZNF323	16	51	67	1767.779
#348	TAL1	16	40	56	844.159
#349	SMAD5	16	38	54	502.382
#350	NR4A3	16	7	23	138.555
#351	KLF10	16	43	59	770.641
#352	VAX2	16	43	59	435.865
#353	SREBF1	16	44	60	954.682
#354	MITF	16	50	66	754.175
#355	ASCL1	16	41	57	735.213
#356	ELF3	16	52	68	933.996
#357	HOXA5	16	41	57	628.572
#358	EGR4	16	46	62	880.328
#359	FOXO1	15	38	53	2463.231
#360	MSRB2	15	33	48	285.92
#361	SATB1	15	35	50	759.703
#362	MSX1	15	41	56	1156.112
#363	TCFL5	15	42	57	786.102
#364	TSC22D2	15	32	47	1057.576
#365	SREBF2	15	44	59	556.079
#366	TFAP4	15	51	66	1546.599
#367	HDAC2	15	31	46	272.539
#368	HNF1A	15	45	60	1222.604
#369	MEIS3P1	15	33	48	283.798
#370	TFAP2A	14	44	58	988.662
#371	ZNF91	14	41	55	1348.764
#372	NR6A1	14	43	57	1067.419
#373	TULP4	14	44	58	287.988
#374	TFCP2	14	48	62	1206.182
#375	TP53	14	37	51	755.907
#376	NR3C2	14	40	54	252.918
#377	VENTX	14	43	57	1413.661
#378	ADNP2	14	40	54	367.773
#379	HOXB1	14	43	57	521.305
#380	WNT5A	14	34	48	815.008
#381	HINFP	14	50	64	1575.881
#382	GTF2IRD1	13	43	56	1503.362
#383	BRD8	13	39	52	1170.205
#384	ELF5	13	33	46	198.434
#385	TSHZ2	13	46	59	674.262
#386	ATF1	13	24	37	236.036
#387	ESR2	13	39	52	684.527
#388	NR4A1	13	14	27	358.881
#389	HOPX	13	44	57	1176.158
#390	STAT6	13	36	49	245.183
#391	OVOL1	13	36	49	340.083
#392	JUNB	13	10	23	219.996
#393	BUD31	13	41	54	807.01
#394	FOXO3	13	35	48	319.896
#395	SCAND2	12	43	55	400.69
#396	TP63	12	40	52	979.419
#397	KLF12	12	43	55	433.154
#398	TFAP2C	12	48	60	1156.248
#399	GCFC1	12	54	66	457.327
#400	AATF	12	39	51	777.874
#401	GATAD1	12	35	47	298.077
#402	NPAS2	12	41	53	334.308
#403	PPARD	12	42	54	584.488
#404	ZNF287	12	41	53	400.776
#405	BCL6	12	39	51	417.978
#406	HNF4A	12	42	54	1004.783
#407	EPAS1	12	30	42	254.454
#408	TADA3	12	42	54	914.619
#409	HMGB1	12	49	61	562.73
#410	ZNF187	12	42	54	419.247
#411	POU6F1	11	45	56	597.19
#412	TFDP2	11	41	52	622.347
#413	HMGA1	11	49	60	452.126
#414	CTBP1	11	31	42	204.431
#415	ZKSCAN5	11	46	57	1733.895
#416	HOXD4	11	49	60	486.15
#417	PBX2	11	43	54	1469.661
#418	SOX9	11	40	51	347.531
#419	RCAN1	11	51	62	294.092
#420	POU5F1B	11	51	62	397.336
#421	NR2F2	11	43	54	290.662
#422	RARA	11	44	55	596.097
#423	UBP1	11	49	60	375.503
#424	FOS	10	16	26	315.712
#425	POU2F2	10	51	61	1059.964
#426	CNOT7	10	48	58	910.763
#427	STAT1	10	25	35	1135.617
#428	VAV1	10	42	52	377.857
#429	ETV5	10	47	57	1107.867
#430	MYC	10	40	50	1196.127
#431	LHX6	10	48	58	769.45
#432	SPDEF	10	49	59	599.221
#433	BCL3	10	40	50	637.489
#434	NR1D2	10	29	39	211.546
#435	EGR1	9	16	25	245.081
#436	NFX1	9	47	56	250.665
#437	RELA	9	43	52	419.509
#438	ESRRA	9	40	49	374.674
#439	ZNF131	9	50	59	2133.902
#440	MYCL1	9	36	45	315.006
#441	CREB1	9	39	48	324.556
#442	TCEAL1	8	41	49	416.731
#443	PFDN1	8	52	60	1217.181
#444	NFATC1	8	50	58	572.585
#445	DBP	8	36	44	650.195
#446	ALX3	8	34	42	363.883
#447	RELB	8	53	61	310.513
#448	GRHL2	8	49	57	1055.081
#449	TEAD4	8	40	48	385.947
#450	PHOX2A	8	38	46	163.271
#451	NR3C1	7	40	47	359.057
#452	NKX2-1	7	48	55	383.302
#453	FUBP1	7	47	54	187.915
#454	ZNF35	7	45	52	539.273
#455	ZNF394	7	51	58	187.246
#456	CLOCK	6	47	53	125.65
#457	TAF10	6	43	49	241.349
#458	ENO1	6	39	45	259.046
#459	PRDM1	6	55	61	332.552
#460	KLF2	6	40	46	1055.783
#461	HMBOX1	6	46	52	166.927
#462	NFATC4	6	45	51	161.613
#463	FOXK2	6	58	64	997.898
#464	ERF	6	50	56	1883.024
#465	MECOM	6	62	68	483.428
#466	BATF3	6	52	58	193.634
#467	LMO4	6	36	42	159.768
#468	IRF7	5	36	41	1768.349
#469	C11orf9	5	49	54	186.705
#470	TSC22D3	5	54	59	172.401
#471	CREB3L2	5	48	53	175.55
#472	ARNTL	5	57	62	246.917
#473	FOXJ1	5	52	57	564.968
#474	LASS6	5	47	52	309.717
#475	CREB3	5	43	48	232.677
#476	BACH1	5	45	50	171.516
#477	RUNX3	5	51	56	872.874
#478	FOSL2	5	42	47	325.101
#479	ISL1	4	39	43	465.144
#480	CTNNB1	4	60	64	1920.827
#481	NR2F1	4	43	47	107.233
#482	HES1	4	37	41	239.746
#483	IRF6	4	62	66	685.967
#484	FOSL1	4	18	22	54.594
#485	PRRX2	4	49	53	72.511
#486	IRF1	4	31	35	112.995
#487	NR0B1	3	48	51	165.253
#488	TAF6	3	58	61	328.896
#489	CDKN2A	3	59	62	243.837
#490	RXRB	3	53	56	69.495
#491	SNAPC5	3	42	45	126.232
#492	ATF6	3	53	56	103.494
#493	HOXB2	2	50	52	604.196
#494	KLF5	2	42	44	46.741
#495	ATF4	1	46	47	14.233
#496	CEBPD	1	42	43	55.819
#497	TRIM29	1	53	54	572.58
#498	CREB3L1	1	51	52	47.192
#499	NKX3-1	0	51	51	0
#500	ZBTB38	0	37	37	0