Hub Rank	Node	Children	Parents	Degree	Betweenness
#1	FOXP1	52	7	59	1583.304
#2	ELK1	50	2	52	81.437
#3	ZEB1	49	3	52	502.133
#4	FOXA1	48	3	51	288.95
#5	ESRRA	47	4	51	2439.439
#6	USF2	46	5	51	189.605
#7	TSHZ1	46	5	51	463.8
#8	ETS1	46	8	54	1655.259
#9	KLF10	45	7	52	2689.968
#10	HNF1B	43	0	43	0
#11	TCF12	42	2	44	233.979
#12	SMAD5	42	7	49	1569.371
#13	HMGA1	40	10	50	1711.223
#14	GATA3	39	10	49	1341.327
#15	MMP14	39	1	40	13.486
#16	SPDEF	38	10	48	3627.347
#17	FOS	36	8	44	870.731
#18	ESR1	36	4	40	419.23
#19	HMGB2	36	7	43	1111.616
#20	ARID4A	35	9	44	2958.511
#21	MLX	35	10	45	1549.101
#22	FOXC1	35	9	44	522.119
#23	ATF1	35	8	43	2012.47
#24	POU5F1B	34	2	36	19.902
#25	TAF4B	34	10	44	1661.222
#26	TCF4	33	4	37	253.233
#27	ANKRD30A	33	9	42	562.664
#28	DMTF1	33	12	45	1779.105
#29	EN1	33	4	37	861.552
#30	NR3C1	32	9	41	1145.912
#31	PRRX1	32	5	37	515.168
#32	TEAD4	32	7	39	861.28
#33	FOXK1	32	8	40	2294.742
#34	XBP1	31	7	38	2907.992
#35	AR	31	5	36	2505.353
#36	RBPJ	31	5	36	796.396
#37	NFE2L2	31	4	35	785.992
#38	FOXM1	31	12	43	1971.388
#39	TSC22D3	30	6	36	178.95
#40	HDAC2	30	9	39	599.358
#41	MNT	30	4	34	454.316
#42	SOX6	30	15	45	2479.768
#43	GLIS2	30	7	37	1112.728
#44	MAF	29	3	32	191.005
#45	E2F4	29	5	34	198.928
#46	ELK3	29	12	41	2361.528
#47	RCOR1	29	8	37	300.899
#48	ZNF639	29	12	41	1424.08
#49	PLSCR1	29	17	46	3086.238
#50	TCEAL1	28	13	41	879.564
#51	PTTG1	28	15	43	1002.887
#52	ZNF217	28	10	38	542.907
#53	TRIM29	27	7	34	407.3
#54	E2F3	27	9	36	983.057
#55	ZBTB38	27	16	43	3341.094
#56	CEBPB	27	17	44	1849.017
#57	FOXO1	27	13	40	1063.184
#58	ZNF444	27	7	34	649.922
#59	TSHZ2	27	12	39	2505.988
#60	MAFB	27	7	34	974.334
#61	FUBP1	26	7	33	218.106
#62	CREBL2	26	17	43	3935.875
#63	RELA	26	9	35	729.258
#64	CNOT8	26	8	34	605.717
#65	AFF1	26	18	44	1370.404
#66	SNAPC4	25	11	36	815.728
#67	TAF10	25	12	37	901.493
#68	PGR	25	8	33	1113.455
#69	GATAD2A	25	10	35	1158.269
#70	ATF2	25	8	33	897.618
#71	TCF7L1	25	8	33	885.501
#72	PRDM2	24	9	33	1879.804
#73	KLF11	24	14	38	2642.46
#74	NFAT5	24	7	31	402.714
#75	NOTCH1	23	10	33	781.61
#76	FOXN3	23	11	34	1312.589
#77	EPAS1	23	12	35	1305.035
#78	ZNF277	23	16	39	2599.238
#79	ZNF496	22	10	32	403.979
#80	RUNX1	22	14	36	1857.499
#81	ELF5	22	14	36	829.106
#82	MEF2D	22	14	36	900.333
#83	PURA	22	11	33	1678.494
#84	CREBZF	22	14	36	800.805
#85	ZRANB2	22	7	29	3835.51
#86	SMAD4	22	8	30	1009.93
#87	KLF5	22	14	36	1070.67
#88	FOXN2	22	16	38	1088.214
#89	ADNP	22	12	34	1445.733
#90	NFIB	22	19	41	783.67
#91	TAF7	22	11	33	1724.317
#92	EBF1	22	10	32	1404.43
#93	PPARA	22	16	38	1241.408
#94	MAFG	21	19	40	2085.636
#95	HSF1	21	12	33	2027.777
#96	TFDP1	21	16	37	4241.191
#97	ZNF83	21	16	37	892.447
#98	ENO1	21	19	40	2863.066
#99	PAX8	21	7	28	118.774
#100	ARNTL2	21	17	38	2051.989
#101	TCF7L2	20	11	31	1913.147
#102	HR	20	10	30	822.307
#103	BHLHE40	20	14	34	1396.076
#104	CSDA	20	13	33	695.763
#105	EDF1	20	17	37	1912.888
#106	HOXD8	20	9	29	2237.138
#107	NFIL3	20	17	37	4040.412
#108	NFATC2	20	10	30	1735.117
#109	GTF2H3	20	8	28	956.396
#110	IKZF1	20	3	23	680.692
#111	ZNF367	19	4	23	331.845
#112	FOXJ3	19	14	33	1162.713
#113	RB1	19	14	33	1824.801
#114	SMAD1	19	15	34	1246.496
#115	MEIS3P1	19	14	33	2271.805
#116	TFCP2L1	19	12	31	1882.795
#117	EGR1	19	12	31	848.49
#118	BRD8	19	11	30	853.636
#119	BLZF1	19	16	35	1805.978
#120	HNRNPK	19	10	29	676.668
#121	SOX10	19	9	28	613.318
#122	PPARD	18	16	34	952.563
#123	FOSB	18	8	26	1964.52
#124	HOXB5	18	6	24	363.165
#125	NR2C2	18	13	31	712.704
#126	TBX19	18	12	30	1256.468
#127	TCF19	18	13	31	662.546
#128	JUN	18	10	28	617.183
#129	CREB3L1	18	10	28	1461.507
#130	KLF4	18	12	30	730.186
#131	PRRX2	18	7	25	101.306
#132	SNAI2	17	10	27	1089.427
#133	YEATS4	17	12	29	2753.019
#134	MLL	17	16	33	953.948
#135	CREBBP	17	13	30	1077.964
#136	MYC	17	19	36	2711.925
#137	NFE2L3	17	17	34	1799.624
#138	SOX7	17	10	27	2636.366
#139	KLF3	17	16	33	1151.765
#140	TRERF1	17	13	30	584.772
#141	BTG2	17	17	34	760.784
#142	RUNX2	17	5	22	1623.911
#143	TCFL5	17	13	30	2253.43
#144	SIX3	16	12	28	2868.098
#145	FLI1	16	7	23	1764.819
#146	SOX8	16	6	22	585.368
#147	SIN3A	16	16	32	2468.913
#148	CREB3L4	16	10	26	265.371
#149	MAX	16	9	25	315.959
#150	GTF2IRD1	16	11	27	1322.715
#151	ATF3	16	11	27	1006.081
#152	NFXL1	16	16	32	1930.304
#153	GLIS3	16	8	24	906.961
#154	EOMES	16	11	27	2597.909
#155	GATAD1	16	13	29	1286.25
#156	E2F8	16	8	24	321.974
#157	EGR3	16	16	32	2687.961
#158	IRF8	16	4	20	170.865
#159	MEIS1	15	10	25	829.893
#160	HOXB2	15	11	26	1305.119
#161	UHRF1	15	15	30	922.22
#162	NR4A2	15	12	27	651.698
#163	MYNN	15	12	27	2079.09
#164	HMGB1	15	10	25	916.753
#165	NFYA	15	17	32	1977.814
#166	BACH1	15	13	28	886.176
#167	HCLS1	15	8	23	867.444
#168	HNRNPAB	15	13	28	1141.377
#169	ARNTL	15	11	26	1078.388
#170	SP140	15	8	23	517.165
#171	TBP	15	10	25	496.482
#172	KLF16	15	12	27	2095.053
#173	ZNF207	14	15	29	623.019
#174	MEF2A	14	16	30	2723.965
#175	CBL	14	10	24	534.069
#176	ZNF445	14	10	24	1740.014
#177	AEBP1	14	15	29	1097.361
#178	NR2F6	14	13	27	1561.152
#179	GATA6	14	17	31	2090.79
#180	ZNF274	14	10	24	979.656
#181	MGA	14	12	26	1392.112
#182	CNOT7	14	13	27	1433.499
#183	AFF4	14	12	26	1248.954
#184	CNBP	14	13	27	1231.897
#185	DLX6	14	8	22	444.148
#186	NOLC1	14	16	30	1068.58
#187	ZNF148	14	16	30	660.989
#188	HOXB3	13	14	27	2086.442
#189	E2F2	13	13	26	2388.338
#190	NFIC	13	10	23	708.938
#191	TAF4	13	11	24	572.098
#192	SMAD6	13	12	25	1053.114
#193	SOX4	13	15	28	1412.354
#194	HOXA2	13	14	27	2243.776
#195	ZKSCAN1	13	12	25	1372.64
#196	ZNF397	13	12	25	1665.257
#197	KLF12	13	12	25	1069.389
#198	HOXA1	13	16	29	1156.516
#199	TFAP2B	13	13	26	2015.752
#200	TAF5	13	13	26	566.803
#201	ZNF33A	13	18	31	1912.815
#202	SNAPC5	13	15	28	1446.893
#203	MBD1	13	18	31	1605.646
#204	RORA	13	14	27	2121.243
#205	BTAF1	13	15	28	1922.597
#206	IRF3	12	9	21	1800.464
#207	SMAD9	12	14	26	2366.889
#208	SCAND1	12	12	24	890.727
#209	CDKN2A	12	19	31	1196.964
#210	SREBF2	12	8	20	642.041
#211	ZNF70	12	20	32	1784.746
#212	ETV6	12	14	26	1061.994
#213	TAF6	12	10	22	299.424
#214	RBCK1	12	18	30	1075.76
#215	ZXDC	12	16	28	2312.016
#216	NR1H3	12	14	26	1590.882
#217	NANOG	12	15	27	655.083
#218	ATF4	12	13	25	479.144
#219	PURB	12	13	25	858.784
#220	RERE	12	12	24	858.267
#221	TFEB	12	13	25	594.059
#222	PA2G4	12	17	29	1214.342
#223	ZFP36L1	12	16	28	1836.731
#224	SLC2A4RG	12	16	28	1533.212
#225	ZNF93	12	18	30	1360.908
#226	ZFP90	12	12	24	2701.041
#227	MZF1	12	16	28	1391.94
#228	NKX3-1	12	10	22	993.374
#229	SREBF1	12	16	28	1503.452
#230	ZNF446	11	9	20	478.298
#231	STAT6	11	17	28	2229.352
#232	TFE3	11	11	22	552.819
#233	HDAC1	11	15	26	776.19
#234	VDR	11	14	25	2572.697
#235	NFIX	11	12	23	705.724
#236	LASS5	11	18	29	1576.866
#237	TSHZ3	11	10	21	852.909
#238	LMO4	11	19	30	914.898
#239	CREB3L2	11	21	32	1123.876
#240	CREB1	11	12	23	1274.195
#241	ZFPM2	11	17	28	3941.168
#242	GAS7	11	14	25	739.678
#243	TSC22D1	11	15	26	1375.136
#244	REST	11	11	22	1372.254
#245	SMAD2	11	13	24	1188.853
#246	NFYB	11	12	23	1081.826
#247	RCAN1	11	16	27	1856.335
#248	SLC30A9	11	12	23	897.816
#249	TBX3	11	16	27	629.464
#250	ZEB2	11	10	21	348.546
#251	NCOR1	11	19	30	1753.602
#252	BCL6	11	19	30	582.372
#253	TBX5	11	13	24	756.238
#254	LHX8	11	4	15	477.193
#255	FBXW7	11	14	25	1400.467
#256	IRX5	11	13	24	1042.151
#257	MSX1	11	12	23	706.09
#258	HEY1	11	20	31	1501.011
#259	HOXC10	11	10	21	1361.726
#260	UBP1	10	20	30	933.937
#261	GRHL2	10	12	22	1493.053
#262	STAT2	10	16	26	1050.075
#263	BCL11B	10	9	19	1128.924
#264	BHLHE41	10	21	31	2345.686
#265	ZGPAT	10	15	25	3517.325
#266	ZFP36L2	10	18	28	2354.442
#267	ELF1	10	13	23	362.258
#268	HOXD9	10	7	17	559.188
#269	RFX5	10	18	28	1785.353
#270	LEF1	10	11	21	2859.267
#271	RUNX3	10	15	25	1509.536
#272	CSRNP1	10	11	21	469.209
#273	ZNF167	10	8	18	284.818
#274	HOXC9	10	12	22	617.162
#275	CREM	10	13	23	521.435
#276	HOXA10	10	9	19	906.033
#277	TWIST1	10	20	30	1395.74
#278	STAT1	10	12	22	1177.553
#279	MITF	10	10	20	303.198
#280	AATF	10	13	23	376.655
#281	HOXB6	9	7	16	899.475
#282	C5orf41	9	20	29	1025.474
#283	TCF7	9	11	20	525.497
#284	ZFP42	9	6	15	824.201
#285	ZNF236	9	12	21	874.941
#286	ONECUT2	9	9	18	734.253
#287	YY1	9	14	23	1297.328
#288	NR2F1	9	19	28	2016.323
#289	PBX2	9	11	20	398.211
#290	GCFC1	9	17	26	1000.738
#291	SPEN	9	13	22	1417.994
#292	RXRA	9	16	25	1607.974
#293	PBX1	9	14	23	1682.755
#294	TFEC	9	11	20	463.093
#295	CITED1	9	10	19	1077.352
#296	RFXAP	9	19	28	708.98
#297	NFX1	9	12	21	738.465
#298	SOX9	9	19	28	1386.606
#299	ELF4	9	20	29	1942.258
#300	KLF6	9	27	36	1940.311
#301	SOX2	9	6	15	836.167
#302	CTNNB1	9	19	28	1230.587
#303	IRF1	9	7	16	219.227
#304	IRF6	9	18	27	3004.032
#305	DLX2	8	12	20	1605.358
#306	PLAGL2	8	21	29	1303.298
#307	MTF1	8	15	23	1912.753
#308	ZIC2	8	6	14	505.553
#309	CUX1	8	13	21	945.576
#310	SCML1	8	17	25	605.47
#311	ZNF213	8	18	26	838.938
#312	AHR	8	15	23	1323.185
#313	MYCN	8	15	23	1647.444
#314	HES1	8	20	28	1065.531
#315	ZNF138	8	16	24	2058.354
#316	ZNF232	8	19	27	418.786
#317	ZNF131	8	16	24	2655.576
#318	TGIF1	8	9	17	535.542
#319	SLC26A3	8	21	29	2717.848
#320	ZNF75D	8	11	19	427.833
#321	E2F5	8	11	19	648.56
#322	ZNF281	8	22	30	1472.249
#323	FOXG1	8	12	20	860.655
#324	EGR2	8	13	21	851.174
#325	AHCTF1	8	16	24	422.806
#326	GLI3	8	14	22	868.25
#327	TAF5L	8	9	17	171.41
#328	ZNF135	8	17	25	1180.369
#329	GATAD2B	8	17	25	1437.275
#330	CSRNP3	8	15	23	914.445
#331	YBX1	8	18	26	414.309
#332	MEF2C	8	17	25	2891.138
#333	KLF7	8	16	24	1546.885
#334	ETV5	7	6	13	418.764
#335	SUPT4H1	7	23	30	1003.895
#336	HIRA	7	18	25	539.29
#337	MXD1	7	23	30	1382.13
#338	HIF1A	7	15	22	937.68
#339	NFIA	7	15	22	747.771
#340	LASS2	7	16	23	1580.884
#341	MEIS2	7	14	21	882.662
#342	PRDM1	7	16	23	783.578
#343	TFAM	7	19	26	1490.283
#344	ATF7	7	20	27	1475.078
#345	POU4F1	7	7	14	521.136
#346	LHX1	7	6	13	800.526
#347	PHF1	7	22	29	528.877
#348	MAFF	7	20	27	928.126
#349	SALL2	7	13	20	539.279
#350	SOX17	7	14	21	919.84
#351	TEAD1	7	14	21	558.675
#352	DMRT1	7	10	17	1160.399
#353	STAT4	7	3	10	247.653
#354	PAX7	7	9	16	678.415
#355	NFATC1	7	14	21	488.981
#356	GLI2	7	12	19	555.757
#357	MEOX2	7	10	17	210.747
#358	SPIB	6	17	23	860.179
#359	ZNF91	6	18	24	563.395
#360	TFAP2A	6	15	21	1538.538
#361	HOXA5	6	4	10	525.704
#362	RNF4	6	13	19	193.443
#363	ZNF33B	6	6	12	268.683
#364	LASS6	6	25	31	945.014
#365	HOPX	6	12	18	1376.885
#366	MSX2	6	16	22	842.731
#367	CBFB	6	17	23	1353.172
#368	GATA2	6	16	22	1201.696
#369	MNX1	6	16	22	2572.254
#370	TCF25	6	16	22	1355.177
#371	SIX2	6	10	16	730.692
#372	SIM1	6	12	18	1672.731
#373	CTBP1	6	20	26	1613.78
#374	ZNF238	6	21	27	900.99
#375	ZNF268	6	16	22	416.601
#376	MECOM	6	12	18	669.162
#377	PAX6	6	16	22	880.646
#378	ASCL2	6	23	29	1925.736
#379	FOXK2	6	11	17	308.69
#380	BUD31	6	20	26	372.478
#381	STAT3	6	19	25	521.028
#382	IRX1	6	20	26	932.736
#383	STAT5B	6	15	21	1112.434
#384	FOXO3	6	12	18	611.72
#385	ATF5	6	10	16	947.989
#386	ZHX1	6	19	25	901.898
#387	CLOCK	6	13	19	704.18
#388	C2orf3	6	16	22	1397.198
#389	TARDBP	6	12	18	129.569
#390	FOSL2	5	23	28	770.19
#391	TRPS1	5	25	30	1248.198
#392	NR3C2	5	15	20	582.7
#393	MAFK	5	19	24	692.378
#394	ZNF449	5	22	27	1166.467
#395	TRIM22	5	16	21	1607.707
#396	PLAG1	5	15	20	885.127
#397	PEG3	5	31	36	2367.134
#398	SP4	5	17	22	422.37
#399	KLF2	5	19	24	657.364
#400	ESX1	5	8	13	424.828
#401	KLF9	5	14	19	1423.061
#402	ZNF45	5	18	23	1057.764
#403	SP3	5	17	22	357.877
#404	OVOL1	5	14	19	1060.147
#405	HOXB8	5	8	13	516.906
#406	ZSCAN18	5	22	27	1753.372
#407	MKX	5	9	14	309.722
#408	CREB5	5	15	20	315.965
#409	CREB3	5	25	30	841.674
#410	ZNF394	5	14	19	552.972
#411	HOXB4	5	11	16	428.845
#412	ARNT	5	15	20	1461.963
#413	THRB	5	25	30	420.124
#414	KDM5A	5	15	20	470.152
#415	TCF3	5	20	25	383.585
#416	ZNF500	5	14	19	473.527
#417	DLX1	5	10	15	1079.269
#418	NR1D2	5	16	21	1405.927
#419	CBFA2T2	5	16	21	255.667
#420	LCOR	5	17	22	549.389
#421	HOXA9	5	15	20	903.608
#422	E2F7	5	15	20	1303.228
#423	MSRB2	5	16	21	1634.952
#424	ZIC1	5	23	28	945.355
#425	ZNF165	5	14	19	566.817
#426	IRX3	5	17	22	1118.261
#427	ARX	5	10	15	551.067
#428	ETS2	4	17	21	554.032
#429	HOXD4	4	15	19	595.889
#430	E2F6	4	15	19	448.214
#431	ELF3	4	16	20	1652.192
#432	NPAT	4	21	25	581.811
#433	PCGF2	4	18	22	1139.619
#434	NR2C1	4	11	15	750.975
#435	CSRNP2	4	18	22	985.953
#436	HOXA11	4	12	16	329.588
#437	RORC	4	26	30	2456.716
#438	HEY2	4	21	25	453.203
#439	ADNP2	4	18	22	664.97
#440	HES6	4	15	19	544.904
#441	IRX4	4	18	22	669.175
#442	IRX2	4	19	23	566.215
#443	NR2F2	4	19	23	558.709
#444	CEBPD	4	21	25	3306.388
#445	PBX3	4	16	20	343.458
#446	SIX4	4	16	20	388.243
#447	LHX2	4	10	14	349.369
#448	NFE2L1	4	16	20	1883.978
#449	BATF	4	13	17	400.527
#450	TSC22D2	4	16	20	456.057
#451	ZNF24	4	17	21	419.564
#452	IRF7	4	12	16	478.073
#453	ZSCAN16	4	22	26	620.171
#454	SCML2	4	17	21	498.453
#455	HOXB7	4	15	19	558.451
#456	TRIM25	4	14	18	264.242
#457	NR4A3	4	13	17	502.697
#458	DDIT3	4	15	19	554.144
#459	ZNF117	4	18	22	1305.911
#460	WT1	4	13	17	626.772
#461	TBX6	4	5	9	337.744
#462	SOX11	4	16	20	440.337
#463	C1orf85	4	12	16	2114.495
#464	MLLT10	4	14	18	522.467
#465	IRF5	3	14	17	1812.627
#466	ARNT2	3	22	25	924.159
#467	HLF	3	17	20	881.745
#468	HOXC4	3	16	19	195.601
#469	MTA1	3	14	17	732.686
#470	ZNF37A	3	22	25	709.195
#471	JUND	3	19	22	351.636
#472	FOXJ1	3	7	10	578.771
#473	WNT5A	3	15	18	268.638
#474	TULP4	3	18	21	722.112
#475	ZNF323	3	13	16	268.528
#476	TFAP2C	3	18	21	1346.601
#477	ZHX2	3	15	18	465.164
#478	KDM5B	3	17	20	415.253
#479	NFATC4	3	8	11	328.178
#480	LHX6	3	14	17	458.841
#481	EHF	2	29	31	1550.548
#482	TFDP2	2	20	22	1041.394
#483	ELF2	2	18	20	71.144
#484	HOXA7	2	10	12	337.479
#485	ESRRG	2	23	25	650.827
#486	ZSCAN2	2	22	24	672.302
#487	IRF9	2	17	19	341.639
#488	PHF5A	2	14	16	77.729
#489	ZNF85	2	20	22	183.192
#490	SATB1	2	23	25	382.596
#491	SHOX	2	6	8	370.579
#492	HMBOX1	1	24	25	111.142
#493	CTCF	1	17	18	303.591
#494	ZFHX3	1	20	21	404.624
#495	FOXO6	1	19	20	104.803
#496	ZNF193	1	16	17	26.944
#497	ZNF174	1	14	15	345.933
#498	ZNF92	1	17	18	99.415
#499	SIX1	0	28	28	0
#500	FOXP2	0	17	17	0