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Hub Rank	Node	Children	Parents	Degree	Betweenness
#1	LHX2	56	6	62	881.344
#2	GATAD2B	51	3	54	1776.657
#3	ZBTB17	45	6	51	346.127
#4	IRF9	43	4	47	854.889
#5	ATF6	40	2	42	596.844
#6	TCF19	40	5	45	1205.781
#7	RELB	38	4	42	1837.221
#8	CTNNB1	37	3	40	208.338
#9	EPAS1	37	10	47	6735.969
#10	PA2G4	37	5	42	4407.499
#11	RFX5	37	2	39	319.826
#12	USF2	36	7	43	1166.418
#13	NFKB2	36	4	40	237.784
#14	NR1H3	35	5	40	2027.132
#15	GTF2H4	34	2	36	136.615
#16	PTTG1	33	5	38	1248.508
#17	MSC	33	5	38	812.659
#18	HNRNPK	32	5	37	4029.363
#19	TRIM28	30	4	34	1272.874
#20	TCF3	30	4	34	435.119
#21	ZNF277	30	10	40	8301.666
#22	C1orf85	30	7	37	1894.558
#23	CDKN2A	30	7	37	3560.361
#24	ASCL1	30	12	42	6762.433
#25	ZSCAN21	30	7	37	1972.128
#26	ZSCAN5A	30	1	31	108.263
#27	TCF4	29	11	40	9298.627
#28	TFAM	28	6	34	1159.431
#29	GABPA	28	3	31	278.155
#30	ZRANB2	28	16	44	7242.361
#31	TFDP1	28	6	34	684.389
#32	E2F1	27	6	33	165.63
#33	SCAND1	27	9	36	823.974
#34	IRF5	26	8	34	1653.02
#35	ZNF187	26	3	29	228.859
#36	SREBF2	26	6	32	580.093
#37	CTBP1	26	6	32	956.265
#38	XBP1	26	12	38	1800.351
#39	EDF1	26	6	32	1080.464
#40	PBX3	26	9	35	1211.146
#41	LZTR1	26	9	35	9093.817
#42	RELA	26	5	31	2885.21
#43	SMAD4	26	6	32	3478.766
#44	SLC2A4RG	25	10	35	902.193
#45	HIF1A	25	5	30	7473.391
#46	BATF3	25	6	31	2529.739
#47	PFDN1	25	7	32	2650.349
#48	HMX2	24	7	31	15277.701
#49	ZNF3	24	6	30	419.359
#50	STAT4	24	9	33	1477.967
#51	SOLH	24	5	29	2734.02
#52	RORA	23	11	34	1327.087
#53	TRIM22	23	5	28	802.36
#54	HOXB7	23	12	35	10457.624
#55	ZNF263	23	6	29	3731.535
#56	NOLC1	22	10	32	3305.413
#57	HNRNPAB	22	6	28	2545.202
#58	RARA	22	7	29	1022.636
#59	ZNF83	22	6	28	4070.319
#60	CCRN4L	22	10	32	1361.997
#61	SCML1	22	9	31	5618.441
#62	NFKB1	21	7	28	3279.771
#63	NME2	21	8	29	4846.913
#64	MSRB2	21	6	27	2282.013
#65	POU2F2	21	11	32	2171.223
#66	E2F4	21	7	28	3487.23
#67	DDIT3	21	11	32	4592.225
#68	BATF	21	11	32	2387.512
#69	NR1H2	21	7	28	2618.644
#70	DRAP1	20	11	31	2698.591
#71	PCGF6	20	8	28	374.801
#72	ZNF207	20	1	21	19.516
#73	NFX1	20	6	26	481.922
#74	ETS1	20	12	32	1125.556
#75	CREB5	20	6	26	160.937
#76	CEBPB	19	7	26	5905.632
#77	RBPJ	19	7	26	1392.999
#78	MEIS2	19	4	23	1025.11
#79	SMAD5	19	6	25	237.255
#80	PCGF2	19	7	26	2035.674
#81	TADA3	19	9	28	348.121
#82	NFIC	19	6	25	251.97
#83	MTA1	19	9	28	304.932
#84	HEY1	19	8	27	1302.03
#85	ELF2	18	8	26	1726.629
#86	KLF9	18	11	29	1426.455
#87	FUBP1	18	9	27	1523.114
#88	ZSCAN18	18	13	31	3370.514
#89	ZNF45	18	11	29	1100.237
#90	NFIL3	18	9	27	6059.138
#91	ZNF35	17	9	26	3857.319
#92	ZNF217	17	8	25	1707.727
#93	HDAC1	17	8	25	1115.154
#94	ATF4	17	12	29	2492.536
#95	RFXAP	17	6	23	730.549
#96	PPARG	17	8	25	242.928
#97	ZNF281	17	7	24	1033.04
#98	SRF	17	8	25	723.49
#99	SP1	17	10	27	2309.537
#100	RNF4	17	8	25	2519.073
#101	PGBD1	17	9	26	420.207
#102	ZFP90	16	5	21	1160.816
#103	CEBPD	16	12	28	8051.298
#104	STAT2	16	13	29	5328.611
#105	RCAN1	16	11	27	1258.022
#106	CTCF	16	6	22	912.208
#107	ADNP	16	6	22	552.602
#108	NFYB	16	8	24	762.582
#109	ZSCAN29	16	8	24	1497.136
#110	ZBTB25	16	9	25	3856.641
#111	ETV5	16	15	31	5426.61
#112	ZFPM1	15	10	25	2483.566
#113	ZNF91	15	8	23	5891.022
#114	ELK1	15	14	29	2171.743
#115	TAF10	15	12	27	1565.904
#116	BTAF1	15	7	22	7602.936
#117	ESRRA	15	6	21	1408.248
#118	STAT6	15	8	23	3372.545
#119	HOXB2	15	12	27	2194.395
#120	NFE2L1	15	9	24	2480.679
#121	MEF2A	15	9	24	530.302
#122	SP3	15	9	24	460.145
#123	E4F1	14	7	21	484.956
#124	TBX15	14	6	20	556.317
#125	HCLS1	14	8	22	664.027
#126	E2F3	14	8	22	554.444
#127	AHCTF1	14	8	22	2418.438
#128	NPAT	14	7	21	1068.071
#129	MYNN	14	8	22	330.482
#130	GTF2H3	14	5	19	782.48
#131	SPEN	14	9	23	1232.013
#132	TCFL5	14	9	23	2863.817
#133	LASS2	14	11	25	1948.015
#134	KLF10	14	9	23	509.553
#135	CBFB	14	9	23	4499.449
#136	SREBF1	14	6	20	455.957
#137	EOMES	14	8	22	3205.157
#138	PBX2	14	7	21	349.176
#139	HDAC2	14	8	22	575.71
#140	ZNF148	13	11	24	7505.711
#141	STAT5A	13	7	20	641.092
#142	RFXANK	13	8	21	209.425
#143	SOX9	13	14	27	3526.045
#144	E2F6	13	6	19	609.612
#145	TFAP2A	13	5	18	148.435
#146	PHF5A	13	8	21	2119.833
#147	RXRB	13	5	18	559.418
#148	ZNF438	13	7	20	389.244
#149	AATF	12	7	19	566.307
#150	NFE2L2	12	11	23	957.981
#151	FOXO3	12	11	23	9265.086
#152	ZHX1	12	10	22	1547.639
#153	REXO4	12	13	25	702.479
#154	ELF1	12	11	23	3261.756
#155	ZNF133	12	11	23	982.031
#156	MLLT10	12	7	19	2194.899
#157	HES6	12	12	24	2651.351
#158	MAX	12	11	23	2974.904
#159	IRF3	12	8	20	369.75
#160	GAS7	12	12	24	1172.71
#161	TSC22D4	12	13	25	2059.332
#162	PLAGL2	11	8	19	1901.73
#163	CNOT7	11	12	23	2976.305
#164	IKZF3	11	9	20	2322.051
#165	SUPT4H1	11	11	22	5404.152
#166	ZFHX3	11	11	22	1073.764
#167	STAT5B	11	9	20	1847.534
#168	CREB3L2	11	11	22	1553.413
#169	FOXO4	11	10	21	4282.266
#170	ZKSCAN4	11	9	20	374.821
#171	ZNF202	11	8	19	1060.159
#172	NFXL1	11	12	23	2205.42
#173	NFIB	11	7	18	2620.311
#174	C5orf41	11	8	19	1028.619
#175	SP4	11	5	16	452.316
#176	ZNF189	11	5	16	345.376
#177	TFEB	10	9	19	2357.536
#178	ZBTB48	10	13	23	628.666
#179	FOXJ2	10	7	17	3883.664
#180	SLC30A9	10	8	18	897.366
#181	TSC22D3	10	12	22	5454.485
#182	NOTCH1	10	12	22	1959.549
#183	POU2F1	10	11	21	555.634
#184	RERE	10	16	26	4500.236
#185	TP53	10	11	21	1844.264
#186	TEAD4	10	16	26	2052.663
#187	TCF25	10	14	24	1222.123
#188	HHEX	10	7	17	86.532
#189	KLF6	10	10	20	1759.684
#190	LASS6	10	12	22	3648.01
#191	USF1	10	10	20	4615.063
#192	ZNF140	10	7	17	649.986
#193	ZC3H8	10	12	22	1013.88
#194	VAV1	10	14	24	2098.003
#195	MZF1	10	12	22	570.385
#196	ZNF85	9	10	19	1451.547
#197	TAF5	9	7	16	1725.014
#198	BCL3	9	10	19	2928.528
#199	E2F5	9	12	21	3615.028
#200	HNF1B	9	10	19	746.993
#201	TAF7	9	10	19	1919.262
#202	PRRX1	9	13	22	1572.742
#203	RUNX1	9	10	19	1322.841
#204	ZNF256	9	10	19	112.066
#205	SALL2	9	10	19	2901.684
#206	NCOR1	9	11	20	475.999
#207	CSRNP2	9	11	20	1165.876
#208	SNAPC4	9	14	23	3369.424
#209	TAF12	9	12	21	1552.052
#210	ZFP36L1	9	12	21	3156.299
#211	ZNF93	9	9	18	1458.841
#212	SCMH1	9	12	21	3313.147
#213	ZHX3	9	9	18	1346.206
#214	SUPT6H	9	9	18	517.324
#215	MEF2C	8	17	25	1322.439
#216	ZNF444	8	9	17	735.798
#217	JDP2	8	12	20	1320.564
#218	AEBP1	8	9	17	780.555
#219	MLX	8	7	15	368.318
#220	IRX6	8	9	17	1694.836
#221	TAF1B	8	12	20	502.971
#222	STAT1	8	10	18	2113.287
#223	SOX18	8	16	24	1251.451
#224	ATF5	8	13	21	4339.788
#225	ZNF165	8	9	17	209.86
#226	RFX3	8	15	23	1286.363
#227	HOXC13	8	3	11	399.894
#228	PURB	8	12	20	884.476
#229	NR2C2	8	15	23	5201.075
#230	HMBOX1	8	8	16	4661.961
#231	KDM5B	8	16	24	2448.908
#232	SIX5	8	4	12	1154.056
#233	FOXO1	8	13	21	2140.497
#234	ATF3	8	12	20	4114.15
#235	TSC22D2	8	8	16	428.857
#236	TEF	8	11	19	1491.866
#237	UBP1	8	11	19	2022.504
#238	BUD31	8	12	20	3048.406
#239	ZNF174	7	13	20	200.585
#240	EGR1	7	13	20	4339.815
#241	PRDM1	7	9	16	220.308
#242	MSL3	7	14	21	3206.126
#243	BHLHE40	7	13	20	1537.333
#244	LEF1	7	16	23	5609.45
#245	CSRNP1	7	14	21	1856.014
#246	RB1	7	18	25	7281.101
#247	RXRA	7	12	19	4143.852
#248	IRF4	7	14	21	785.568
#249	NR3C1	7	13	20	643.553
#250	FOXA3	7	15	22	7523.84
#251	IRF1	7	15	22	620.252
#252	MESP1	7	16	23	3062.244
#253	IRF8	7	6	13	522.922
#254	EBF1	7	13	20	1433.168
#255	ZNF394	7	9	16	305.075
#256	CLOCK	7	8	15	173.604
#257	POU5F1	7	13	20	3045.417
#258	ARID4A	7	9	16	2826.154
#259	AHR	7	10	17	562.468
#260	FOXD4L4	7	9	16	1008.351
#261	CIR1	7	9	16	502.565
#262	TCEAL1	7	10	17	252.537
#263	FOXN2	7	12	19	3758.838
#264	CREB1	7	10	17	973.99
#265	CNBP	7	8	15	2809.531
#266	PPARD	7	10	17	1174.021
#267	ALS2CR8	7	10	17	1053.763
#268	ATF6B	7	10	17	1592.386
#269	FOSL2	7	8	15	757.853
#270	HIRA	6	10	16	961.898
#271	E2F7	6	18	24	1723.599
#272	GCFC1	6	7	13	1191.127
#273	PKNOX1	6	8	14	1439.982
#274	NFATC3	6	7	13	500.686
#275	UBN1	6	12	18	1336.795
#276	MNT	6	13	19	518.638
#277	ETV6	6	18	24	2644.072
#278	CREBZF	6	12	18	1574.681
#279	CREB3L4	6	11	17	1110.597
#280	HMG20A	6	14	20	1158.419
#281	MYC	6	7	13	547.256
#282	RBCK1	6	9	15	681.819
#283	NR2F2	6	13	19	338.25
#284	BCL11B	6	11	17	3739.317
#285	TAF13	6	14	20	445.735
#286	FOXP4	6	8	14	3803.057
#287	SPI1	6	11	17	1383.967
#288	T	6	10	16	2086.814
#289	SP140	6	11	17	4585.064
#290	TAF5L	6	14	20	2725.519
#291	NFYA	5	10	15	606.335
#292	ESR2	5	12	17	1336.478
#293	GATAD2A	5	7	12	643.825
#294	DMTF1	5	11	16	1632.87
#295	SNAPC5	5	15	20	1698.867
#296	NFYC	5	6	11	10.704
#297	RUNX3	5	10	15	754.713
#298	MYCL1	5	8	13	572.546
#299	ZNF236	5	14	19	1268.491
#300	ZNF175	5	8	13	407.393
#301	HOXC4	5	22	27	3999.759
#302	MNX1	5	14	19	1645.434
#303	TCF12	5	6	11	306.33
#304	ZSCAN16	5	12	17	132.41
#305	TRERF1	5	12	17	2287.273
#306	HNF4G	5	10	15	1888.019
#307	TFAP4	5	9	14	223.662
#308	HOXC6	5	6	11	211.985
#309	PURA	5	13	18	787.704
#310	JUND	5	14	19	614.21
#311	MAFG	5	8	13	204.907
#312	KLF12	5	11	16	911.533
#313	ZSCAN2	5	11	16	1292.348
#314	CBFA2T3	5	15	20	2018.843
#315	RAX2	5	8	13	366.664
#316	SNAPC2	5	8	13	163.221
#317	NR2F6	5	12	17	1041.891
#318	ZNF323	5	11	16	583.492
#319	LASS5	5	12	17	422.842
#320	MEF2D	5	9	14	681.079
#321	PHTF1	5	15	20	443.198
#322	PBX4	5	13	18	4091.809
#323	UHRF1	5	9	14	248.816
#324	CNOT8	5	15	20	578.529
#325	ETV4	5	16	21	5119.475
#326	NFE2L3	5	9	14	368.597
#327	IRX1	5	9	14	1428.343
#328	MTA2	4	17	21	175.457
#329	FBXW7	4	14	18	4755.799
#330	ARNT	4	15	19	1210.108
#331	IRF7	4	13	17	204.668
#332	ZNF274	4	13	17	127.171
#333	TGIF2	4	11	15	1954.302
#334	DMRT1	4	4	8	156.431
#335	ENO1	4	8	12	4062.635
#336	PLSCR1	4	13	17	1025.781
#337	PLAG1	4	15	19	501.265
#338	MXD1	4	12	16	387.866
#339	STAT3	4	13	17	402.55
#340	REL	4	13	17	1063.825
#341	ZNF446	4	8	12	1251.642
#342	ZNF434	4	12	16	796.034
#343	CITED2	4	17	21	1565.197
#344	HOPX	4	6	10	151.981
#345	FOXJ3	4	8	12	326.619
#346	ZKSCAN3	4	10	14	2035.107
#347	FOS	4	10	14	1600.025
#348	ZNF193	4	17	21	1015.871
#349	HOXB4	4	12	16	316.454
#350	HES5	4	10	14	572.182
#351	ZNF213	4	9	13	848.751
#352	ZNF134	4	11	15	226.815
#353	CREB3L3	4	10	14	784.283
#354	HMGB2	4	13	17	4099.915
#355	TFCP2L1	4	8	12	381.769
#356	ZKSCAN1	4	9	13	597.313
#357	SOX30	4	6	10	2673.104
#358	ELF4	4	11	15	695.966
#359	BTG2	3	13	16	922.906
#360	ZNF197	3	12	15	376.6
#361	MSX1	3	15	18	1296.401
#362	SMAD1	3	13	16	1961.907
#363	SIN3A	3	14	17	2548.643
#364	LMO4	3	13	16	2629.277
#365	HES1	3	15	18	2616.147
#366	DBP	3	13	16	2346.856
#367	BCL6	3	10	13	833.4
#368	ZFP37	3	10	13	3284.607
#369	EMX1	3	12	15	2277.965
#370	ISX	3	10	13	899.978
#371	ERF	3	9	12	279.556
#372	KLF11	3	8	11	325.028
#373	TGIF1	3	13	16	166.221
#374	FOXA2	3	7	10	1348.442
#375	SPIB	3	14	17	1263.835
#376	YEATS4	3	16	19	977.713
#377	GTF2H2	3	12	15	282.191
#378	MTA3	3	11	14	1127.539
#379	NR2C1	3	11	14	153.794
#380	ZNF167	3	7	10	1203.783
#381	MTF1	3	14	17	904.02
#382	IKZF1	3	19	22	3237.439
#383	ZNF232	3	11	14	831.431
#384	WNT5A	3	6	9	1524.407
#385	KLF16	3	10	13	1346.717
#386	AFF1	3	7	10	199.521
#387	ERG	3	13	16	76.871
#388	ZXDC	3	9	12	191.515
#389	TP63	3	13	16	191.586
#390	ZNF215	3	8	11	2294.117
#391	PRDM2	3	6	9	146.183
#392	RFX1	3	15	18	4138.686
#393	ATF2	3	10	13	688.018
#394	ZHX2	3	13	16	2909.608
#395	CSDA	3	10	13	148.369
#396	YY1	3	8	11	238.042
#397	SOX4	3	16	19	2818.039
#398	TAF4	3	12	15	727.353
#399	ARNTL	2	15	17	1931.265
#400	STRN3	2	14	16	727.245
#401	E2F8	2	16	18	1115.239
#402	HCFC1	2	16	18	1736.999
#403	FOSL1	2	9	11	86.03
#404	ZNF69	2	6	8	72.301
#405	FOXP1	2	9	11	240.204
#406	HSF1	2	14	16	263.698
#407	AFF4	2	10	12	241.312
#408	GATA3	2	10	12	27.007
#409	FOXC1	2	7	9	144.609
#410	MYPOP	2	11	13	177.277
#411	MLL	2	10	12	146.056
#412	HOMEZ	2	6	8	25.72
#413	HIC1	2	8	10	315.689
#414	FOXM1	2	12	14	528.252
#415	TFDP2	2	14	16	718.485
#416	ECSIT	2	15	17	262.661
#417	HSF2	2	6	8	44.484
#418	TSC22D1	2	10	12	2174.061
#419	ZEB1	2	10	12	69.846
#420	NPAS1	2	11	13	2617.223
#421	TFE3	2	10	12	672.472
#422	TCF7	2	12	14	1615.296
#423	CREBBP	2	9	11	129.174
#424	ELK4	2	10	12	1074.055
#425	GTF2IRD1	2	15	17	1815.136
#426	ZKSCAN2	2	12	14	521.141
#427	ZNF132	2	14	16	3456.793
#428	TCF20	2	13	15	1794.306
#429	REST	2	7	9	2176.574
#430	CUX1	2	9	11	145.039
#431	THRB	2	12	14	596.989
#432	CREBL2	2	7	9	59.531
#433	MIXL1	2	11	13	395.193
#434	ZXDA	2	12	14	1142.773
#435	E2F2	2	11	13	171.704
#436	SMAD3	2	22	24	1590.437
#437	HOXA6	1	8	9	1515.108
#438	FLI1	1	19	20	212.533
#439	NFATC1	1	11	12	16.595
#440	VDR	1	10	11	602.401
#441	NR4A2	1	11	12	293.049
#442	ZNF33B	1	10	11	355.433
#443	ZNF37A	1	11	12	25.826
#444	GTF2I	1	7	8	645.539
#445	SMAD2	1	11	12	432.117
#446	NKX3-1	1	12	13	43.543
#447	ARID3A	1	9	10	1231.523
#448	CREB3	1	12	13	453.886
#449	ZNF24	1	12	13	1730.04
#450	TULP4	1	17	18	1386.484
#451	ZEB2	1	10	11	1090.582
#452	TBX1	1	11	12	176.457
#453	TADA2A	1	14	15	38.609
#454	ZNF643	1	10	11	38.65
#455	TSHZ1	1	15	16	94.113
#456	BHLHE41	1	8	9	37.567
#457	NR1D2	1	16	17	139.922
#458	CREM	1	10	11	233.169
#459	TARDBP	1	12	13	184.324
#460	ADNP2	1	9	10	495.689
#461	LCOR	1	10	11	1170.414
#462	RUNX2	1	7	8	191.366
#463	TRIM25	1	12	13	2594.971
#464	ZNF169	1	8	9	116.215
#465	ZNF238	1	12	13	103.111
#466	EGR2	0	15	15	0
#467	ATF1	0	11	11	0
#468	GATAD1	0	9	9	0
#469	HMG20B	0	8	8	0
#470	ZNF498	0	14	14	0
#471	KLF2	0	15	15	0
#472	SNAI3	0	9	9	0
#473	ZNF33A	0	11	11	0
#474	GABPB1	0	16	16	0
#475	ZNF92	0	11	11	0
#476	FOXG1	0	11	11	0
#477	VSX2	0	10	10	0
#478	IRF2	0	7	7	0
#479	ELF5	0	10	10	0
#480	CUX2	0	9	9	0
#481	ZFHX4	0	7	7	0
#482	PHF1	0	15	15	0
#483	ZNF268	0	12	12	0
#484	POU3F1	0	13	13	0
#485	HINFP	0	4	4	0
#486	TFCP2	0	9	9	0
#487	ELF3	0	8	8	0
#488	SCRT1	0	9	9	0
#489	MYBL2	0	9	9	0
#490	FOXN3	0	9	9	0
#491	HOXB1	0	12	12	0
#492	LHX6	0	10	10	0
#493	FOSB	0	12	12	0
#494	JUN	0	12	12	0
#495	MBD1	0	9	9	0
#496	ZNF18	0	11	11	0
#497	TRPS1	0	7	7	0
#498	MECOM	0	5	5	0
#499	CBL	0	13	13	0
#500	HESX1	0	8	8	0